BGC0002344: A50926 A biosynthetic gene cluster from Nonomuraea coxensis DSM 45129
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 2,825,582 - 2,894,646 nt. (total: 69,065 nt).
This entry is originally from NCBI GenBank CP068985.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002344
Short description A50926 A biosynthetic gene cluster from Nonomuraea coxensis DSM 45129
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP068985.1
2825582 - 2894646
via Gene expression correlated with compound production
Compounds
  • A50926 A
  • A50926 B
Species Nonomuraea coxensis DSM 45129 [taxonomy]
References
Chemical products information
A50926 A Evidence:
Copy SMILES
A50926 B Evidence:
Copy SMILES
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Nocox_13260
  • QYC40269.1
  • noc1
 2825582 - 2826730 (-) Hydroxymandelate oxidase Hmo
    copy AA seq
    copy Nt seq
    • Nocox_13265
    • QYC40270.1
    • noc2
    		 2826723 - 2827793 (-) 4-hydroxymandelate synthase HmaS
      copy AA seq
      copy Nt seq
      • Nocox_13270
      • QYC40271.1
      • noc3
      		 2827962 - 2829248 (-) Hydroxyphenylglycine aminotransferase HpgT
        copy AA seq
        copy Nt seq
        • Nocox_13275
        • QYC40272.1
        • noc4
        		 2829427 - 2830713 (-) High-affinity Na(+)/H(+) antiporter
          copy AA seq
          copy Nt seq
          • Nocox_13280
          • QYC40273.1
          • noc5
          		 2830710 - 2831531 (-) Enoyl-CoA dehydratase DpgD
            copy AA seq
            copy Nt seq
            • Nocox_13285
            • QYC40274.1
            • noc6
            		 2831528 - 2832832 (-) Dihydroxyphenylacetyl-CoA dioxygenase DpgC
              copy AA seq
              copy Nt seq
              • Nocox_13290
              • QYC40275.1
              • noc7
              		 2832829 - 2833497 (-) enoyl-CoA hydratase DpgB
                copy AA seq
                copy Nt seq
                • Nocox_13295
                • QYC40276.1
                • noc8
                		 2833491 - 2834603 (-) Type III polyketide syntase DpgA
                  copy AA seq
                  copy Nt seq
                  • Nocox_13300
                  • QYC40277.1
                  • noc9
                  		 2834773 - 2835279 (-) 4-hydroxybutyrate-CoA thioesterase
                    copy AA seq
                    copy Nt seq
                    • Nocox_13305
                    • QYC40278.1
                    • noc10
                    		 2835676 - 2837265 (-) beta-hydroxylase
                      copy AA seq
                      copy Nt seq
                      • Nocox_13310
                      • QYC40279.1
                      • noc11
                      		 2837356 - 2838183 (-) Methyltransferase
                        copy AA seq
                        copy Nt seq
                        • Nocox_13315
                        • QYC40280.1
                        • noc12
                        		 2838344 - 2840737 (-) ABC transporter, ATP-binding/permease protein
                          copy AA seq
                          copy Nt seq
                          • Nocox_13320
                          • QYC40281.1
                          • noc13
                          		 2840737 - 2841435 (-) ABC transporter, ATP-binding protein
                            copy AA seq
                            copy Nt seq
                            • Nocox_13325
                            • QYC40282.1
                            • noc14
                            		 2841597 - 2843204 (-) Mannosyltransferase
                              copy AA seq
                              copy Nt seq
                              • Nocox_13330
                              • QYC40283.1
                              • noc15
                              		 2843244 - 2844056 (-) Deacetylase
                                copy AA seq
                                copy Nt seq
                                • Nocox_13335
                                • QYC40284.1
                                • noc16
                                		 2844330 - 2845577 (-) Sensor protein precursor
                                  copy AA seq
                                  copy Nt seq
                                  • Nocox_13340
                                  • QYC40285.1
                                  • noc17
                                  		 2845694 - 2847841 (-) Acyltransferase
                                    copy AA seq
                                    copy Nt seq
                                    • Nocox_13345
                                    • QYC40286.1
                                    • noc18
                                    		 2848141 - 2850087 (+) Multidrug export ATP-binding/permease protein
                                      copy AA seq
                                      copy Nt seq
                                      • Nocox_13350
                                      • QYC40287.1
                                      • nocA
                                      		 2850084 - 2856365 (+) A50926 NRPS, modules 1-2
                                        copy AA seq
                                        copy Nt seq
                                        • Nocox_13355
                                        • QYC40288.1
                                        • nocB
                                        		 2856362 - 2859553 (+) A50926 NRPS, module 3
                                          copy AA seq
                                          copy Nt seq
                                          • Nocox_13360
                                          • QYC40289.1
                                          • nocC
                                          		 2859889 - 2872134 (+) A50926 NRPS, modules 4-5-6
                                            copy AA seq
                                            copy Nt seq
                                            • Nocox_13365
                                            • QYC40290.1
                                            • nocD
                                            		 2872153 - 2877765 (+) A50926 NRPS, module 7
                                              copy AA seq
                                              copy Nt seq
                                              • Nocox_13370
                                              • QYC40291.1
                                              • noc19
                                              		 2877765 - 2877974 (+) MbtH-like protein
                                                copy AA seq
                                                copy Nt seq
                                                • Nocox_13375
                                                • QYC40292.1
                                                • noc20
                                                		 2878049 - 2879230 (+) Crosslinking oxygenase OxyA
                                                  copy AA seq
                                                  copy Nt seq
                                                  • Nocox_13380
                                                  • QYC40293.1
                                                  • noc21
                                                  		 2879251 - 2880405 (+) Crosslinking oxygenase OxyC
                                                    copy AA seq
                                                    copy Nt seq
                                                    • Nocox_13385
                                                    • QYC40294.1
                                                    • noc22
                                                    		 2880395 - 2881591 (+) Crosslinking oxygenase OxyB
                                                      copy AA seq
                                                      copy Nt seq
                                                      • Nocox_13390
                                                      • QYC40295.1
                                                      • noc23
                                                      		 2881776 - 2882999 (+) Croslinking oxygenase OxyE
                                                        copy AA seq
                                                        copy Nt seq
                                                        • Nocox_13395
                                                        • QYC40296.1
                                                        • noc24
                                                        		 2883024 - 2884496 (+) Halogenase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • Nocox_13400
                                                          • QYC40297.1
                                                          • noc25
                                                          		 2884550 - 2885764 (+) Glycosyltransferase GtfB
                                                            copy AA seq
                                                            copy Nt seq
                                                            • Nocox_13405
                                                            • QYC40298.1
                                                            • noc26
                                                            		 2885767 - 2886726 (+) Acetyltransferase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • Nocox_13410
                                                              • QYC40299.1
                                                              • noc27
                                                              		 2886744 - 2887373 (-) VanY-carboxypeptidase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • Nocox_13415
                                                                • QYC40300.1
                                                                • noc28
                                                                		 2887468 - 2888121 (-) Response regulator
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • Nocox_13420
                                                                  • QYC40301.1
                                                                  • noc29
                                                                  		 2888167 - 2889258 (-) prephenate dehydrogenase Pdh
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • Nocox_13425
                                                                    • QYC40302.1
                                                                    • noc30
                                                                    		 2889497 - 2890261 (+) Transposase DDE domain protein
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • Nocox_13430
                                                                      • QYC40303.1
                                                                      • nocRII
                                                                      		 2890996 - 2891961 (+) StrR-like transcriptional regulator NocRII
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • Nocox_13435
                                                                        • QYC40304.1
                                                                        • nocRI
                                                                        		 2892061 - 2894646 (+) LuxR-like transcriptional regulator NocRI
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          Biosynthesis information

                                                                          Biosynthetic modules

                                                                          Name
                                                                          Unk01
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          nocA
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk02
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          nocA
                                                                          Substrates
                                                                          tyrosine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk03
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          nocB
                                                                          Substrates
                                                                          3,5-dihydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk04
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          nocC
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk05
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          nocC
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk06
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          nocC
                                                                          Substrates
                                                                          tyrosine (evidence: Structure-based inference, Homology)
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk07
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          nocD
                                                                          Substrates
                                                                          3,5-dihydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Annotation changelog

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Entry added
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2022-09-15
                                                                          Added NRP substrate specificities
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Detailed domain annotation
                                                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                          A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                          Selected features only
                                                                          Show module domains
                                                                          Similar known gene clusters from MIBiG 4.0
                                                                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                          Click on reference genes to show details of similarities to genes within the current region.
                                                                          Click on an accession to open that entry in the MiBIG database.