BGC0002346 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002346 (Saccharopolyspora sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	11,935	High	kyamicin	ribosomal:RiPP

BGC0002346 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 11,935 nt. (total: 11,935 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,936
Label		BGC0002346

Tailoring functions

Lyases: cyclase

kyaM: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002346.3	1.00	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.75	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0001579.4	0.74	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001660.3	0.74	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000563.4	0.60	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.59	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001576.3	0.59	ribosomal	divamide A	Prochloron didemni
BGC0000528.5	0.57	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001364.3	0.57	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002346.3	1.00	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.75	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0001579.4	0.74	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001660.3	0.74	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000563.4	0.60	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.59	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001576.3	0.59	ribosomal	divamide A	Prochloron didemni
BGC0000528.5	0.57	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001364.3	0.57	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for kyaM

kyaA

Leader:

MSDTILRQAVIDAEFRSALIADPAAFG

Core:

VEPAELPDAVEAVDQESLDFWTKGIAANEVVACASTCSAGPFTFACDGSTK

Core with dehydrations:

VEPAELPDAVEAVDQEDhaLDFWDhbKGIAANEVVACysADhaDhbCysDhaAGPFDhbFACysDGDhaDhbK

antiSMASH-DB 4.0 matches for kyaA

49.1%

NZ_BMRD01000003.1and 1 other:

NZ_JANBBD010000039.1 Lanthipeptides: BS35_RS35910_lanthipeptide

Lanthipeptides: IEZ14_RS08160_lanthipeptide

DQESLDFWTKGIAANEVVACASTCSAGPFTFACDGSTK

D SL +WT+G+AA + ACASTCS+GPFTFACDGSTK

DTASLGYWTEGVAAVDAYACASTCSSGPFTFACDGSTK

49.0%

NZ_JADG01000011.1:

Lanthipeptides: P696_RS0120030_lanthipeptide

VEAVDQESLDFWTKGIAANEVVACASTCSAGPFTFACDGSTK

VE D E L +WT+G+AA ++ AC+STCS GPFT CDG+TK

VEQPDAEQLGYWTEGVAAVDIYACSSTCSFGPFTIVCDGTTK

47.1%

NZ_FUWS01000010.1:

Lanthipeptides: B5D66_RS17810_lanthipeptide

VEAVDQESLDFWTKGIAANEVVACASTCSAGPFTFACDGSTK

VE D E+++ +T+ + A+E+ ACASTCS GPFT ACDG+TK

VERQDHEAIEAFTEAVVASEIYACASTCSFGPFTIACDGTTK

with 4 more sequence matches

31.4%

NZ_JAPFGB010000043.1:

Lanthipeptides: OOZ19_RS28825_lanthipeptide

CASTCSAGPFTFACDGSTK

CASTCS+GPFT CDGSTK

CASTCSSGPFTILCDGSTK

23.5%

NZ_CP073318.1:

Lanthipeptides: JJ691_RS07165_lanthipeptide

CASTCSAGPFTFACDGSTK

C +CS GPFT CDG+TK

CVQSCSWGPFTAVCDGNTK

21.6%

NZ_CP059557.1:

Lanthipeptides: H2Q94_RS19875_lanthipeptide

CASTCSAGPFTFACDGSTK

C +CS GP T CDG+TK

CVQSCSWGPVTAVCDGNTK

17.6%

NZ_AP023359.1:

Lanthipeptides: allorf_7977296_7977442_lanthipeptide

GIAANEVVACASTCSAGP

GIA +E++ TCS GP

GIAPHEIL---QTCSVGP

MIBiG 4.0 matches for kyaA

25.5%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

CASTCSAGPFTFACDGSTK

C +CS GPFTF CDG+TK

CRQSCSFGPFTFVCDGNTK

9.8%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

TKGIAANEVVACASTCS

KG V C +C+

NKGAYCTLTVECMPSCN

allorf_00015_00143

Leader:

MDFGRWISVDPFGA

Core:

LRCLPKVEKELSSRSLDGPPRGWVAENG

Core with dehydrations:

LRCysLPKVEKELDhaDhaRDhaLDGPPRGWVAENG

MIBiG 4.0 matches for allorf_00015_00143

17.9%

BGC0001639.3 (OUH62395.1):

Lasso peptide: klebsidin

DGPPRGWVAENG

DGP + NG

DGPIIEFFNPNG

allorf_00261_00395

Leader:

MIERTVVEVS

Core:

AQRFDPLTRLSKNCARSSADPGKNPRSGDAHLLS

Core with dehydrations:

AQRFDPLDhbRLDhaKNCysARDhaDhaADPGKNPRDhaGDAHLLDha

antiSMASH-DB 4.0 matches for allorf_00261_00395

27.0%

NZ_CP027779.1:

Lanthipeptides: C7M58_RS10750_lanthipeptide

PLTRLSKNCARSS--ADPGKNPR

P T +S NC R+S + G PR

PTTGMSANCCRNSRHVNEGPAPR

26.5%

NZ_CP013140.1:

Lanthipeptides: allorf_2670844_2670996_lanthipeptide

QRFDPLTRLSKNCARSSADPGKNPR

Q P +R C R+ A G+ PR

QAMKPRSRPCTPCVRAGACRGRQPR

20.6%

NZ_MQUQ01000028.1:

Lanthipeptides: allorf_072254_072382_lanthipeptide

LTRLSKNCARSSADPGKNP

TR+++ A +A G NP

FTRVARRVAGIAAGCGVNP

with 2 more sequence matches

13.6%

NZ_RYYV01000004.1:

Lanthipeptides: allorf_108254_108448_lanthipeptide

AQRFDPLTRLSKNCA

A+R D + R +++CA

AERIDTMFRTTQSCA

11.7%

NZ_CP029711.1and 1 other:

NZ_CP029711.1 Lanthipeptides: DKM19_RS49800_lanthipeptide

Lanthipeptides: DKM19_RS49800_lanthipeptide

RFDPLTRLSKNCARSSA

RF +TRL+ + AR+

RFQDVTRLAGDVARNGV

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

kyaA - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 5102.4 Da

Molecular weight: 5105.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5123.6 Da N = 1; 5141.6 Da N = 2; 5159.6 Da N = 3; 5177.6 Da N = 4; 5195.7 Da N = 5

allorf_00015_00143 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 3038.6 Da

Molecular weight: 3040.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3058.5 Da N = 1; 3076.5 Da N = 2

allorf_00261_00395 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 3556.9 Da

Molecular weight: 3558.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3576.9 Da N = 1; 3595.0 Da N = 2; 3613.0 Da N = 3; 3631.0 Da N = 4; 3649.0 Da N = 5