BGC0002348 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002348 (Aspergillus terreus NIH2624)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS-like	1	42,779	High	aspulvinone E	NRPS:Type I

BGC0002348 - Region 1 - NRPS-like

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Location: 1 - 42,779 nt. (total: 42,779 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,780
Label		BGC0002348

Tailoring functions

Ligases: ligase

ATEG_03563: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002348.2	0.97	NRPS	aspulvinone E	Aspergillus terreus NIH2624
BGC0002274.2	0.79	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.76	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002277.2	0.74	NRPS	atromentin	Suillus grevillei
BGC0001668.4	0.49	NRPS	microperfuranone	Aspergillus nidulans FGSC A4
BGC0002271.2	0.45	NRPS	asterriquinone CT5	Aspergillus terreus NIH2624
BGC0000442.5	0.44	NRPS	terrequinone A	Aspergillus nidulans FGSC A4
BGC0001168.5	0.42	NRPS	Livipeptin	Streptomyces lividans 1326
BGC0002596.2	0.41	PKS	lecanoric acid, orsellinic acid	Claviceps purpurea 20.1
BGC0001712.3	0.40	other (other)	ochrindole A	Aspergillus steynii IBT 23096

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002348.2	0.97	NRPS	aspulvinone E	Aspergillus terreus NIH2624
BGC0002274.2	0.79	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.76	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002277.2	0.74	NRPS	atromentin	Suillus grevillei
BGC0001668.4	0.49	NRPS	microperfuranone	Aspergillus nidulans FGSC A4
BGC0002271.2	0.45	NRPS	asterriquinone CT5	Aspergillus terreus NIH2624
BGC0000442.5	0.44	NRPS	terrequinone A	Aspergillus nidulans FGSC A4
BGC0001168.5	0.42	NRPS	Livipeptin	Streptomyces lividans 1326
BGC0002596.2	0.41	PKS	lecanoric acid, orsellinic acid	Claviceps purpurea 20.1
BGC0001712.3	0.40	other (other)	ochrindole A	Aspergillus steynii IBT 23096

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 42779:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ATEG_03563: X

AMP-binding (10..434): X

nrpys: 4-ohPpa

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VAIFAGGAGK
Nearest Stachelhaus code(s):: 4-ohPpa VAIFAGGAGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor