BGC0002351: thanafactin A biosynthetic gene cluster from Pseudomonas sp. SHC52
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Location: 1 - 37,128 nt. (total: 37,128 nt).
This entry is originally from NCBI GenBank MT431590.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002351
Short description thanafactin A biosynthetic gene cluster from Pseudomonas sp. SHC52
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT431590.1
1 - 37128
via Knock-out studies
Compounds
  • thanafactin A
Species Pseudomonas sp. SHC52 [taxonomy]
References
Chemical products information
thanafactin A Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QKM21613.1
 1 - 1278 (-) FAD-dependent oxidoreductase
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    • QKM21614.1
    		 1374 - 3077 (-) dihydroxy acid dehydratase
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      • QKM21615.1
      		 3155 - 4162 (+) LysR family transcriptional regulator
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        • QKM21619.1
        • thf1
        		 4415 - 14062 (+) non-ribosomal peptide synthetase
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          • QKM21620.1
          • thf2
          		 14059 - 31857 (+) non-ribosomal peptide synthetase
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            • QKM21616.1
            • thf3
            		 31931 - 33295 (+) major facilitator superfamily transporter
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              • QKM21617.1
              		 33979 - 35589 (-) response regulator
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                • QKM21621.1
                		 35694 - 36326 (+) response regulator
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                  • QKM21618.1
                  		 36607 - 37128 (+) hypothetical protein
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    thf1
                    Substrates
                    valine (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    thf1
                    Substrates
                    alanine (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    thf1
                    Substrates
                    glutamine (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    thf2
                    Substrates
                    alanine (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    thf2
                    Substrates
                    valine (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    thf2
                    Substrates
                    alanine (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk07
                    Type
                    nrps-type1
                    Genes
                    thf2
                    Substrates
                    proline (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk08
                    Type
                    nrps-type1
                    Genes
                    thf2
                    Substrates
                    threonine (evidence: Structure-based inference, Sequence-based prediction)
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Added chemical structures for compounds: thanafactin A.
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-10-07
                    Added NPAtlas links to compounds: thanafactin A.
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Entry added
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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