BGC0002356: mediomycin A biosynthetic gene cluster from Streptomyces blastmyceticus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 149 - 161,671 nt. (total: 161,523 nt).
This entry is originally from NCBI GenBank LC208005.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002356
Short description mediomycin A biosynthetic gene cluster from Streptomyces blastmyceticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • other (other)
Loci
LC208005.1
149 - 161671
via Heterologous expression
Compounds
  • mediomycin A
Species Streptomyces blastmyceticus [taxonomy]
References
Chemical products information
mediomycin A Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAW35626.1
  • medA
 149 - 739 (-)
    copy AA seq
    copy Nt seq
    • BAW35627.1
    • medB
    		 899 - 2029 (-) sulfotransferase
      copy AA seq
      copy Nt seq
      • BAW35628.1
      • medC
      		 2543 - 5371 (+) putative LuxR family transcriptional regulator
        copy AA seq
        copy Nt seq
        • BAW35629.1
        • medD
        		 5503 - 7134 (+) putative L-arginine mono-oxygenase
          copy AA seq
          copy Nt seq
          • BAW35630.1
          • medE
          		 7211 - 8617 (-) putative 4-guanidinylbutanoate:CoA ligase
            copy AA seq
            copy Nt seq
            • BAW35631.1
            • medF
            		 8681 - 9322 (-) putative type II TE
              copy AA seq
              copy Nt seq
              • BAW35632.1
              • medG
              		 9842 - 10786 (+) putative 4-guanidinylbutanoyl-CoA:ACP acyltransferase
                copy AA seq
                copy Nt seq
                • BAW35633.1
                • med9
                		 10945 - 22446 (-) modular polyketide synthase
                  copy AA seq
                  copy Nt seq
                  • BAW35634.1
                  • med8
                  		 22528 - 39621 (-) modular polyketide synthase
                    copy AA seq
                    copy Nt seq
                    • BAW35635.1
                    • med7
                    		 39677 - 49276 (-) modular polyketide synthase
                      copy AA seq
                      copy Nt seq
                      • BAW35636.1
                      • med6
                      		 49365 - 70760 (-) modular polyketide synthase
                        copy AA seq
                        copy Nt seq
                        • BAW35637.1
                        • med5
                        		 70824 - 86309 (-) modular polyketide synthase
                          copy AA seq
                          copy Nt seq
                          • BAW35638.1
                          • med4
                          		 86533 - 91488 (-) modular polyketide synthase
                            copy AA seq
                            copy Nt seq
                            • BAW35639.1
                            • med3
                            		 91616 - 116827 (-) modular polyketide synthase
                              copy AA seq
                              copy Nt seq
                              • BAW35640.1
                              • med2
                              		 116853 - 126989 (-) modular polyketide synthase
                                copy AA seq
                                copy Nt seq
                                • BAW35641.1
                                • med1
                                		 126996 - 151358 (-) modular polyketide synthase
                                  copy AA seq
                                  copy Nt seq
                                  • BAW35642.1
                                  • medH
                                  		 151633 - 153189 (-) putative membrane protein
                                    copy AA seq
                                    copy Nt seq
                                    • BAW35643.1
                                    • medI
                                    		 153186 - 153668 (-) putative membrane protein
                                      copy AA seq
                                      copy Nt seq
                                      • BAW35644.1
                                      • medJ
                                      		 153755 - 154288 (-)
                                        copy AA seq
                                        copy Nt seq
                                        • BAW35645.1
                                        • medK
                                        		 154456 - 155709 (+) putative histidine kinase
                                          copy AA seq
                                          copy Nt seq
                                          • BAW35646.1
                                          • medL
                                          		 155702 - 156331 (+) putative two-component system response regulator
                                            copy AA seq
                                            copy Nt seq
                                            • BAW35647.1
                                            • medM
                                            		 156389 - 159283 (-) putative LuxR-family transcriptional regulator
                                              copy AA seq
                                              copy Nt seq
                                              • BAW35648.1
                                              • medN
                                              		 159372 - 160022 (-) putative type II TE
                                                copy AA seq
                                                copy Nt seq
                                                • BAW35649.1
                                                • medO
                                                		 160405 - 161190 (+) putative 4-guanidinobutyramide hydrolase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • BAW35650.1
                                                  • medP
                                                  		 161231 - 161671 (-) putative transcriptional regulator
                                                    copy AA seq
                                                    copy Nt seq
                                                    Biosynthesis information
                                                    Annotation changelog

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Entry added
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Updated bioactivity data
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
                                                    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                    A domain glossary is available here, and an explanation of the visualisation is available here.
                                                    Selected features only
                                                    Show module domains
                                                    Similar known gene clusters from MIBiG 4.0
                                                    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                    Click on reference genes to show details of similarities to genes within the current region.
                                                    Click on an accession to open that entry in the MiBIG database.