BGC0002357: neomediomycin B biosynthetic gene cluster from Streptomyces sp. RK95-74
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Location: 1,987 - 185,326 nt. (total: 183,340 nt).
This entry is originally from NCBI GenBank LC208004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002357
Short description neomediomycin B biosynthetic gene cluster from Streptomyces sp. RK95-74
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • other (other)
Loci
LC208004.1
1987 - 185326
via Heterologous expression
Compounds
  • neomediomycin B
Species Streptomyces sp. RK95-74 [taxonomy]
References
Chemical products information
neomediomycin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAW35598.1
  • nmdA
 1987 - 3483 (+) putative methylmalonic acid semialdehyde dehydrogenase
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    • BAW35599.1
    • nmdB
    		 3628 - 4071 (+) hypothetical protein
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      • BAW35600.1
      • nmdC
      		 4156 - 6249 (+) putative integral membrane protein
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        • BAW35601.1
        • nmdD
        		 6493 - 7251 (+) putative type II TE
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          • BAW35602.1
          • nmdE
          		 7340 - 10183 (+) putative transcriptional regulator
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            • BAW35603.1
            • nmdF
            		 10205 - 10837 (-) putative DNA-binding response regulator
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              • BAW35604.1
              • nmdG
              		 10830 - 12110 (-) putative two-component system sensor kinase
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                • BAW35605.1
                • nmdH
                		 12245 - 12820 (+) hypothetical protein
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                  • BAW35606.1
                  • nmdI
                  		 12889 - 13389 (+) putative membrane protein
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                    • BAW35607.1
                    • nmdJ
                    		 13494 - 14930 (+) putative membrane protein
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                      • BAW35608.1
                      • nmd1
                      		 15242 - 54211 (+) modular polyketide synthase
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                        • BAW35609.1
                        • nmd2
                        		 54262 - 65442 (+) modular polyketide synthase
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                          • BAW35610.1
                          • nmd3
                          		 65469 - 85640 (+) modular polyketide synthase
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                            • BAW35611.1
                            • nmd4
                            		 85708 - 90672 (+) modular polyketide synthase
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                              • BAW35612.1
                              • nmd5
                              		 90919 - 106437 (+) modular polyketide synthase
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                                • BAW35613.1
                                • nmd6
                                		 106489 - 122601 (+) modular polyketide synthase
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                                  • BAW35614.1
                                  • nmd7
                                  		 122658 - 132275 (+) modular polyketide synthase
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                                    • BAW35615.1
                                    • nmd8
                                    		 132332 - 149440 (+) modular polyketide synthase
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                                      • BAW35616.1
                                      • nmd9
                                      		 149501 - 171664 (+) modular polyketide synthase
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                                        • BAW35617.1
                                        • nmdK
                                        		 171777 - 172724 (-) putative acyl transferase
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                                          • BAW35618.1
                                          • nmdL
                                          		 172765 - 174381 (-) putative ABC-2 type transporter
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                                            • BAW35619.1
                                            • nmdM
                                            		 174378 - 175385 (-) putative ABC transporter
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                                              • BAW35620.1
                                              • nmdN
                                              		 175705 - 176367 (+) putative type II TE
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                                                • BAW35621.1
                                                • nmdO
                                                		 176424 - 177836 (+) putative acyl CoA ligase
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                                                  • BAW35622.1
                                                  • nmdP
                                                  		 177948 - 179606 (-) putative amino oxidase
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                                                    • BAW35623.1
                                                    • nmdQ
                                                    		 179646 - 182426 (-) putative LuxR family transcriptional regulator
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                                                      • BAW35624.1
                                                      • nmdR
                                                      		 183092 - 184135 (+) putative sulfotransferase
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                                                        • BAW35625.1
                                                        • nmdS
                                                        		 184328 - 185326 (+) putative amidinohydrolase
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                                                          Biosynthesis information
                                                          Annotation changelog

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Added chemical structures for compounds: neomediomycin B.
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-10-07
                                                          Added NPAtlas links to compounds: neomediomycin B.
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Entry added
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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