BGC0002357 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002357 (Streptomyces sp. RK95-74)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	186,131	High	neomediomycin B	PKS+other:other

BGC0002357 - Region 1 - T1PKS

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Location: 1 - 186,131 nt. (total: 186,131 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 186,132
Label		BGC0002357

Tailoring functions

Oxidoreductases: dehydrogenase

nmdA: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: acylase sulfotransferase

nmd2: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

nmd7: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

nmdK: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

nmdR: Sulfotransferase domain

extras: Sulfotransfer_3: Sulfotransferase domain

Hydrolases: esterase

nmdD: thioesterase

smcogs: SMCOG1004: thioesterase

nmdN: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

nmd1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nmd3: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nmd4: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

nmd5: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nmd6: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nmd8: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nmd9: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nmdO: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002357.3	1.00	PKS, other (other)	neomediomycin B	Streptomyces sp. RK95-74
BGC0002355.2	0.79	PKS, other (other)	tetrafibricin	Streptomyces neyagawaensis
BGC0001662.4	0.78	PKS	mediomycin A	Kitasatospora mediocidica
BGC0002356.3	0.77	PKS, other (other)	mediomycin A	Streptomyces blastmyceticus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002072.3	0.70	PKS	linearmycin A, linearmycin B, linearmycin C, linearmycin C	Streptomyces sp. Mg1
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0002498.3	0.69	other (other)	desulfoclethramycin, clethramycin	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002357.3	1.00	PKS, other (other)	neomediomycin B	Streptomyces sp. RK95-74
BGC0002355.2	0.79	PKS, other (other)	tetrafibricin	Streptomyces neyagawaensis
BGC0001662.4	0.78	PKS	mediomycin A	Kitasatospora mediocidica
BGC0002356.3	0.77	PKS, other (other)	mediomycin A	Streptomyces blastmyceticus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002072.3	0.70	PKS	linearmycin A, linearmycin B, linearmycin C, linearmycin C	Streptomyces sp. Mg1
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0002498.3	0.69	other (other)	desulfoclethramycin, clethramycin	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 186131:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ohmal - ohmal - ohmal - ccmal - ohmal - ccmal) + (redmal - ohmal) + (ohmal - ccmal - ohmal - ccmal) + (Me-ohmal) + (ohmal - ccmal - ccmal) + (ccmal - ccmal - ccmal) + (Me-ohmal - Me-ohmal) + (ccmal - redmal - ccmal) + (ccmal - ccmal - Me-ccmal - ccmal)
Non-colinear ordering:: nmd1 + nmd2 + nmd3 + nmd4 + nmd5 + nmd6 + nmd7 + nmd8 + nmd9

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

nmd1: mal - mal - mal - mal - mal - mal - mal - mal

PKS_AT (690..985): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 233.9
inactive: 129.9
Methoxymalonyl-CoA: 86.0
Methylmalonyl-CoA: 81.0
Isobutyryl-CoA: 54.4
Ethylmalonyl-CoA: 43.9
Propionyl-CoA: 31.9
Acetyl-CoA: 24.7
Benzoyl-CoA: 23.8
CHC-CoA: 16.3
trans-1,2-CPDA: 15.9
2-Methylbutyryl-CoA: 12.8
fatty_acid: 9.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (2224..2515): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 241.7
inactive: 128.0
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 68.3
Propionyl-CoA: 40.4
Isobutyryl-CoA: 34.6
Ethylmalonyl-CoA: 31.2
Benzoyl-CoA: 25.9
Acetyl-CoA: 23.4
2-Methylbutyryl-CoA: 17.9
trans-1,2-CPDA: 17.1
CHC-CoA: 15.3
fatty_acid: 10.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (4003..4295): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 239.8
inactive: 132.3
Methoxymalonyl-CoA: 70.5
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 39.8
Isobutyryl-CoA: 37.9
Ethylmalonyl-CoA: 36.7
Benzoyl-CoA: 27.5
Acetyl-CoA: 25.4
trans-1,2-CPDA: 19.0
2-Methylbutyryl-CoA: 17.8
CHC-CoA: 13.7
fatty_acid: 10.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (5532..5825): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 239.3
inactive: 121.5
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 70.5
Propionyl-CoA: 46.6
Ethylmalonyl-CoA: 30.7
Isobutyryl-CoA: 30.4
Benzoyl-CoA: 25.7
Acetyl-CoA: 25.0
2-Methylbutyryl-CoA: 23.7
trans-1,2-CPDA: 20.4
CHC-CoA: 16.6
fatty_acid: 9.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (7063..7354): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.0
inactive: 125.6
Methoxymalonyl-CoA: 70.5
Methylmalonyl-CoA: 67.4
Propionyl-CoA: 44.6
Isobutyryl-CoA: 31.7
Benzoyl-CoA: 27.5
Acetyl-CoA: 27.2
2-Methylbutyryl-CoA: 21.4
trans-1,2-CPDA: 21.0
CHC-CoA: 13.8
fatty_acid: 10.7
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -3.1

PKS_AT (8594..8887): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 238.7
inactive: 124.1
Methoxymalonyl-CoA: 70.2
Methylmalonyl-CoA: 68.4
Propionyl-CoA: 42.0
Benzoyl-CoA: 26.6
Isobutyryl-CoA: 25.6
Ethylmalonyl-CoA: 25.5
trans-1,2-CPDA: 24.9
Acetyl-CoA: 23.9
2-Methylbutyryl-CoA: 15.8
CHC-CoA: 14.8
fatty_acid: 11.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (10368..10659): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 236.3
inactive: 122.6
Methoxymalonyl-CoA: 69.0
Methylmalonyl-CoA: 68.0
Propionyl-CoA: 48.8
Isobutyryl-CoA: 32.8
Acetyl-CoA: 24.8
Ethylmalonyl-CoA: 24.5
2-Methylbutyryl-CoA: 23.6
Benzoyl-CoA: 23.5
trans-1,2-CPDA: 18.0
CHC-CoA: 14.6
fatty_acid: 9.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (11904..12197): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 226.0
inactive: 121.5
Methoxymalonyl-CoA: 73.7
Methylmalonyl-CoA: 70.0
Propionyl-CoA: 45.1
Isobutyryl-CoA: 36.3
Ethylmalonyl-CoA: 31.7
trans-1,2-CPDA: 24.7
Benzoyl-CoA: 22.5
Acetyl-CoA: 20.9
2-Methylbutyryl-CoA: 18.4
CHC-CoA: 13.8
fatty_acid: 10.9
3-Methylbutyryl-CoA: 0.0

nmd2: mal - mal

PKS_AT (572..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.3
inactive: 122.2
Methoxymalonyl-CoA: 69.7
Methylmalonyl-CoA: 68.4
Propionyl-CoA: 49.3
Ethylmalonyl-CoA: 27.3
2-Methylbutyryl-CoA: 24.1
Acetyl-CoA: 23.5
Isobutyryl-CoA: 20.3
Benzoyl-CoA: 20.0
CHC-CoA: 17.5
trans-1,2-CPDA: 14.6
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2650..2940): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.1
inactive: 132.4
Methoxymalonyl-CoA: 70.9
Methylmalonyl-CoA: 68.2
Propionyl-CoA: 47.7
Isobutyryl-CoA: 29.4
Ethylmalonyl-CoA: 29.0
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 24.8
Benzoyl-CoA: 20.0
CHC-CoA: 16.6
trans-1,2-CPDA: 15.7
fatty_acid: 10.3
3-Methylbutyryl-CoA: 0.0

nmd3: mal - mal - mal - mal

PKS_AT (571..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 243.6
inactive: 128.1
Methoxymalonyl-CoA: 71.1
Methylmalonyl-CoA: 68.7
Propionyl-CoA: 46.3
Ethylmalonyl-CoA: 35.3
Isobutyryl-CoA: 28.3
Benzoyl-CoA: 27.7
Acetyl-CoA: 23.3
2-Methylbutyryl-CoA: 21.7
trans-1,2-CPDA: 20.0
CHC-CoA: 15.7
fatty_acid: 10.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2127..2418): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 247.0
inactive: 120.8
Methoxymalonyl-CoA: 74.5
Methylmalonyl-CoA: 72.2
Propionyl-CoA: 46.9
Ethylmalonyl-CoA: 39.1
Isobutyryl-CoA: 26.5
Benzoyl-CoA: 25.6
Acetyl-CoA: 22.0
2-Methylbutyryl-CoA: 21.8
trans-1,2-CPDA: 17.7
CHC-CoA: 16.9
fatty_acid: 10.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3877..4168): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 238.8
inactive: 117.3
Methoxymalonyl-CoA: 72.9
Methylmalonyl-CoA: 69.3
Propionyl-CoA: 47.0
Ethylmalonyl-CoA: 31.9
Isobutyryl-CoA: 27.6
2-Methylbutyryl-CoA: 24.4
Benzoyl-CoA: 23.6
Acetyl-CoA: 21.6
CHC-CoA: 16.9
trans-1,2-CPDA: 15.5
fatty_acid: 11.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (5418..5710): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.7
inactive: 115.8
Methoxymalonyl-CoA: 62.0
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 40.3
Acetyl-CoA: 26.4
Benzoyl-CoA: 22.8
Isobutyryl-CoA: 19.1
Ethylmalonyl-CoA: 17.3
trans-1,2-CPDA: 15.0
CHC-CoA: 12.8
2-Methylbutyryl-CoA: 11.4
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

nmd4: mmal

PKS_AT (567..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.9
Ethylmalonyl-CoA: 213.8
Methoxymalonyl-CoA: 175.0
2-Methylbutyryl-CoA: 134.0
trans-1,2-CPDA: 123.7
Malonyl-CoA: 98.8
CHC-CoA: 97.2
Propionyl-CoA: 94.9
Isobutyryl-CoA: 87.9
Benzoyl-CoA: 72.3
3-Methylbutyryl-CoA: 64.8
Acetyl-CoA: 43.4
fatty_acid: 36.5
inactive: 33.6

nmd5: mal - mal - mal

PKS_AT (575..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 242.8
inactive: 116.7
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 63.9
Propionyl-CoA: 33.3
Isobutyryl-CoA: 31.2
Ethylmalonyl-CoA: 29.3
Benzoyl-CoA: 21.6
2-Methylbutyryl-CoA: 21.1
Acetyl-CoA: 17.1
CHC-CoA: 11.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2126..2410): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 239.9
inactive: 124.3
Methoxymalonyl-CoA: 64.5
Methylmalonyl-CoA: 62.8
Propionyl-CoA: 42.4
Acetyl-CoA: 24.5
Benzoyl-CoA: 22.7
Isobutyryl-CoA: 21.0
Ethylmalonyl-CoA: 20.7
trans-1,2-CPDA: 20.6
CHC-CoA: 15.9
2-Methylbutyryl-CoA: 13.0
fatty_acid: 9.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3874..4172): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 234.9
inactive: 119.0
Methoxymalonyl-CoA: 76.0
Methylmalonyl-CoA: 72.5
Propionyl-CoA: 49.2
Ethylmalonyl-CoA: 40.1
Isobutyryl-CoA: 32.9
2-Methylbutyryl-CoA: 32.0
Acetyl-CoA: 25.4
Benzoyl-CoA: 23.3
CHC-CoA: 20.7
trans-1,2-CPDA: 15.2
fatty_acid: 10.8
3-Methylbutyryl-CoA: 0.0

nmd6: mal - mal - mal

PKS_AT (573..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 236.1
inactive: 119.2
Methoxymalonyl-CoA: 71.0
Methylmalonyl-CoA: 68.9
Propionyl-CoA: 44.5
Isobutyryl-CoA: 31.3
Ethylmalonyl-CoA: 30.1
Benzoyl-CoA: 25.8
Acetyl-CoA: 24.9
2-Methylbutyryl-CoA: 23.6
trans-1,2-CPDA: 21.8
CHC-CoA: 14.4
fatty_acid: 11.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2316..2600): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.4
inactive: 126.1
Methoxymalonyl-CoA: 69.8
Methylmalonyl-CoA: 68.1
Propionyl-CoA: 44.0
Isobutyryl-CoA: 31.8
Benzoyl-CoA: 29.5
Acetyl-CoA: 26.9
Ethylmalonyl-CoA: 25.3
2-Methylbutyryl-CoA: 24.4
trans-1,2-CPDA: 19.7
CHC-CoA: 18.5
fatty_acid: 14.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (4058..4347): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 244.3
inactive: 129.1
Methoxymalonyl-CoA: 74.9
Methylmalonyl-CoA: 70.8
Propionyl-CoA: 42.8
Isobutyryl-CoA: 34.7
Benzoyl-CoA: 30.1
2-Methylbutyryl-CoA: 27.5
Acetyl-CoA: 26.9
trans-1,2-CPDA: 17.1
CHC-CoA: 15.0
fatty_acid: 11.1
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -2.7

nmd7: mmal - mmal

PKS_AT (568..867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 222.3
Ethylmalonyl-CoA: 217.9
Methoxymalonyl-CoA: 175.4
2-Methylbutyryl-CoA: 137.8
trans-1,2-CPDA: 126.5
CHC-CoA: 105.7
Malonyl-CoA: 98.5
Propionyl-CoA: 97.6
Isobutyryl-CoA: 89.7
Benzoyl-CoA: 68.7
3-Methylbutyryl-CoA: 60.1
Acetyl-CoA: 47.0
fatty_acid: 34.0
inactive: 30.1

PKS_AT (2120..2419): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 220.2
Ethylmalonyl-CoA: 209.6
Methoxymalonyl-CoA: 173.5
2-Methylbutyryl-CoA: 144.4
trans-1,2-CPDA: 127.0
Propionyl-CoA: 100.0
Malonyl-CoA: 95.0
CHC-CoA: 91.2
Isobutyryl-CoA: 85.9
Benzoyl-CoA: 65.8
3-Methylbutyryl-CoA: 62.1
Acetyl-CoA: 50.1
fatty_acid: 37.7
inactive: 33.9

nmd8: mal - mal - mal

PKS_AT (570..860): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.4
inactive: 136.1
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 66.2
Isobutyryl-CoA: 48.3
Propionyl-CoA: 42.1
Ethylmalonyl-CoA: 38.9
Benzoyl-CoA: 27.6
Acetyl-CoA: 24.8
2-Methylbutyryl-CoA: 22.9
trans-1,2-CPDA: 21.6
fatty_acid: 15.5
CHC-CoA: 14.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2328..2617): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 239.3
inactive: 124.6
Methoxymalonyl-CoA: 67.1
Methylmalonyl-CoA: 64.2
Propionyl-CoA: 43.2
Isobutyryl-CoA: 31.5
Ethylmalonyl-CoA: 29.6
Benzoyl-CoA: 22.4
Acetyl-CoA: 17.6
2-Methylbutyryl-CoA: 15.2
CHC-CoA: 11.3
trans-1,2-CPDA: 11.2
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4402..4684): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.5
inactive: 132.2
Methoxymalonyl-CoA: 72.5
Methylmalonyl-CoA: 69.5
Propionyl-CoA: 46.9
Ethylmalonyl-CoA: 32.4
Isobutyryl-CoA: 27.3
Acetyl-CoA: 27.3
2-Methylbutyryl-CoA: 25.6
Benzoyl-CoA: 18.7
CHC-CoA: 16.2
trans-1,2-CPDA: 12.7
fatty_acid: 11.1
3-Methylbutyryl-CoA: 0.0

nmd9: mal - mal - mmal - mal

PKS_AT (579..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.7
inactive: 119.4
Methoxymalonyl-CoA: 65.1
Methylmalonyl-CoA: 62.2
Propionyl-CoA: 34.5
Ethylmalonyl-CoA: 30.9
Isobutyryl-CoA: 29.8
Benzoyl-CoA: 29.1
trans-1,2-CPDA: 25.2
Acetyl-CoA: 25.2
2-Methylbutyryl-CoA: 19.4
CHC-CoA: 17.4
fatty_acid: 11.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2338..2627): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.8
inactive: 126.7
Methylmalonyl-CoA: 71.2
Methoxymalonyl-CoA: 70.4
Propionyl-CoA: 48.0
Ethylmalonyl-CoA: 35.6
Isobutyryl-CoA: 30.5
Benzoyl-CoA: 27.3
Acetyl-CoA: 24.0
CHC-CoA: 23.9
trans-1,2-CPDA: 23.3
2-Methylbutyryl-CoA: 16.6
fatty_acid: 13.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (4093..4392): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 220.4
Ethylmalonyl-CoA: 215.0
Methoxymalonyl-CoA: 174.2
2-Methylbutyryl-CoA: 133.0
trans-1,2-CPDA: 127.7
CHC-CoA: 103.4
Propionyl-CoA: 96.0
Malonyl-CoA: 95.1
Isobutyryl-CoA: 82.2
Benzoyl-CoA: 67.3
3-Methylbutyryl-CoA: 59.7
Acetyl-CoA: 47.6
fatty_acid: 37.2
inactive: 25.2

PKS_AT (5859..6148): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 233.5
inactive: 123.8
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 55.1
Propionyl-CoA: 43.5
Isobutyryl-CoA: 24.1
Benzoyl-CoA: 21.6
Acetyl-CoA: 19.4
Ethylmalonyl-CoA: 16.7
2-Methylbutyryl-CoA: 13.5
trans-1,2-CPDA: 12.4
CHC-CoA: 10.6
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

nmdK: pk

PKS_AT (14..276): pk

ATSignature: (unknown)

No matches above 50%

minowa: CHC-CoA

Prediction, score:

CHC-CoA: 12.8
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

nmdO: X

AMP-binding (10..371): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: QYSDCGSAFK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor