BGC0002361: baikalomycin B biosynthetic gene cluster from Streptomyces sp. IB201691-2A2
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Location: 48,768 - 84,023 nt. (total: 35,256 nt).
This entry is originally from NCBI GenBank SPQF01000031.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002361
Short description baikalomycin B biosynthetic gene cluster from Streptomyces sp. IB201691-2A2
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • saccharide (None)
Loci
SPQF01000031.1
48768 - 84023
via Heterologous expression, Knock-out studies
Compounds
  • baikalomycin B
  • baikalomycin A
  • baikalomycin C
Species Streptomyces sp. IB201691-2A2 [taxonomy]
References
Chemical products information
baikalomycin B Evidence:
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Chemical database entries
NPAtlas
baikalomycin A Evidence:
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Chemical database entries
NPAtlas
baikalomycin C Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • E4K73_44335
  • TRO56967.1
 48768 - 49520 (+) IclR family transcriptional regulator
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    • E4K73_44340
    • TRO56968.1
    		 49737 - 51335 (+) FAD-binding oxidoreductase
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      • E4K73_44345
      • TRO56969.1
      		 51373 - 51822 (+) hypothetical protein
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        • E4K73_44350
        • TRO56970.1
        		 52710 - 53546 (-) response regulator transcription factor
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          • E4K73_44355
          • TRO56971.1
          		 53805 - 54923 (-) NADH:flavin oxidoreductase
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            • E4K73_44360
            • TRO57000.1
            		 55011 - 56504 (-) DHA2 family efflux MFS transporter permease subunit
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              • E4K73_44365
              • TRO56972.1
              		 56609 - 57208 (-) NADPH-dependent oxidoreductase
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                • E4K73_44370
                • TRO56973.1
                		 57326 - 58081 (+) TetR family transcriptional regulator
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                  • E4K73_44375
                  • TRO56974.1
                  		 58262 - 59098 (+) hypothetical protein
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                    • E4K73_44380
                    • TRO56975.1
                    		 59330 - 60814 (+) monooxygenase
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                      • E4K73_44385
                      • TRO56976.1
                      		 60873 - 61199 (+) TcmI family type II polyketide cyclase
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                        • E4K73_44390
                        • TRO56977.1
                        		 61196 - 62485 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                          • E4K73_44395
                          • TRO56978.1
                          		 62482 - 63708 (+) ketosynthase chain-length factor
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                            • E4K73_44400
                            • TRO56979.1
                            		 63765 - 64034 (+) acyl carrier protein
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                              • E4K73_44405
                              • TRO56980.1
                              		 64067 - 64867 (+) SDR family NAD(P)-dependent oxidoreductase
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                                • E4K73_44410
                                • TRO56981.1
                                		 64894 - 65832 (+) cyclase
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                                  • E4K73_44415
                                  • TRO56982.1
                                  		 65836 - 67833 (+) SDR family oxidoreductase
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                                    • E4K73_44420
                                    • TRO56983.1
                                    		 67951 - 69174 (+) MFS transporter
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                                      • E4K73_44425
                                      • TRO56984.1
                                      		 69207 - 70499 (+) activator-dependent family glycosyltransferase
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                                        • E4K73_44430
                                        • TRO56985.1
                                        		 70539 - 71711 (+) DUF1205 domain-containing protein
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                                          • E4K73_44435
                                          • TRO57001.1
                                          		 71773 - 72363 (+) dTDP-4-keto-6-deoxy-D-glucose epimerase
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                                            • E4K73_44440
                                            • TRO57002.1
                                            		 72366 - 73496 (+) DUF1205 domain-containing protein
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                                              • E4K73_44445
                                              • TRO56986.1
                                              		 73581 - 74648 (+) glucose-1-phosphate thymidylyltransferase
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                                                • E4K73_44450
                                                • TRO56987.1
                                                • rfbB
                                                		 74645 - 75631 (+) dTDP-glucose 4,6-dehydratase
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                                                  • E4K73_44455
                                                  • TRO56988.1
                                                  		 75624 - 76622 (+) NAD(P)-dependent oxidoreductase
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                                                    • E4K73_44460
                                                    • TRO56989.1
                                                    • rfbH
                                                    		 76622 - 77926 (+) lipopolysaccharide biosynthesis protein RfbH
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                                                      • E4K73_44465
                                                      • TRO56990.1
                                                      		 77993 - 79042 (+) hypothetical protein
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                                                        • E4K73_44470
                                                        • TRO56991.1
                                                        		 79055 - 80452 (+) NDP-hexose 2,3-dehydratase
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                                                          • E4K73_44475
                                                          • TRO57003.1
                                                          		 80479 - 81501 (+) Gfo/Idh/MocA family oxidoreductase
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                                                            • E4K73_44480
                                                            • TRO56992.1
                                                            		 81428 - 82183 (+) 4'-phosphopantetheinyl transferase superfamily protein
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                                                              • E4K73_44485
                                                              • TRO56993.1
                                                              		 82200 - 83771 (+) acyl-CoA carboxylase subunit beta
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                                                                • E4K73_44490
                                                                • TRO56994.1
                                                                		 83783 - 83989 (+) acyl-CoA carboxylase subunit epsilon
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                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Changed chemical structures for compounds: baikalomycin C, baikalomycin B, baikalomycin A.
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-10-07
                                                                  Added NPAtlas links to compounds: baikalomycin C, baikalomycin B, baikalomycin A.
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Entry added
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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