LOCUS       BGC0002363             22640 bp    DNA     linear   BCT 25-MAY-2021
DEFINITION  Streptomyces sp. strain SCSIO11878 genomic sequence, sequence.
ACCESSION   BGC0002363
VERSION     BGC0002363
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 08:41:12
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22640
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             <1..372
                     /codon_start=1
                     /product="ribosomal protein"
                     /protein_id="QVN25642.1"
                     /transl_table=11
                     /translation="VPTIQQLVRKGRQDKVEKNKTPALEGSPQRRGVCTRVFTTTPKKP
                     NSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDT
                     QGVKNRKQARSRYGAKKEK"
     source          1..22640
                     /db_xref="taxon:1931"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="SCSIO11878"
     protocluster    1..22640
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7532:16252]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7533..16252
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="1"
     cand_cluster    1..22640
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="chemical_hybrid"
                     /product="thiopeptide"
                     /product="LAP"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..22640
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002363"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22640
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="thiopeptide"
                     /product="LAP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..18879
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5253:8879]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      5254..8879
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="2"
     CDS             375..845
                     /codon_start=1
                     /product="30S ribosomal protein"
                     /protein_id="QVN25643.1"
                     /transl_table=11
                     /translation="MPRKGPAPKRPVIIDPVYSSPLVTSLINKILLDGKRSTAERIVYG
                     AMEGLREKTGADPVITLKRALENVKPSLEVKSRRVGGATYQVPIEVKPGRAATLALRWV
                     VGYSRARREKTMTERLMNELLDASNGLGAAVKKREDTHKMAESNKAFAHYRW"
     CDS             884..3013
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 126.4; E-value:
                     2.4e-38)"
                     /gene_kind="biosynthetic-additional"
                     /product="translation elongation factor G"
                     /protein_id="QVN25644.1"
                     /transl_table=11
                     /translation="MATTSLDLAKVRNIGIMAHIDAGKTTTTERILFYTGVSYKIGEVH
                     DGAATMDWMEQEQERGITITSAATTCHWPLNDVDHTINIIDTPGHVDFTVEVERSLRVL
                     DGAVTVFDGVAGVEPQSETVWRQADRYGVPRICFVNKLDRTGAEFHRCVDMIVQRLGAV
                     PLVMQLPIGAEADFKGVVDLVSMKAFVWSDEAAKGEMYDTVEIPDTHKEAAEEWRGKLL
                     EAVSENDDQMMELYLEGEEPTEEQLHDAIRRITLASKGSADSVTVTPVFCGTAFKNKGV
                     QPLLDAVVRYLPSPLDVEAIEGHDVKDAELVVKRKPSDDEPFSGLAFKIASDPHLGKLT
                     FVRIYSGRLEAGTAVLNSVKGKKERIGKIYRMHANKREEIASVGAGDIVAVMGLKQTTT
                     GETLCDDKNPVILESMDFPAPVIQVAIEPKSKGDQEKLGVAIQRLSEEDPSFQVHSDEE
                     TGQTIIGGMGELHLEVLVDRMKREFRVEANVGKPQVAYRETIRKAVERIDYTHKKQTGG
                     TGQFAKVQIAIEPIEGGDASYEFVNKVTGGRIPREYIPSVDAGAQEAMQFGILAGYEMV
                     GVRVTLLDGGYHEVDSSELAFKIAGSQAFKEGARKASPVLLEPMMAVEVTTPEDYMGEV
                     VGDINSRRGQIQAMEERHGARVVKGLVPLSEMFGYVGDLRSKTSGRASYSMQFDSYAEV
                     PRNVAEEIIAKAKGE"
     CDS             3161..4354
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 341.2; E-value:
                     2.2e-103)"
                     /gene_kind="biosynthetic-additional"
                     /product="elongation factor Tu"
                     /protein_id="QVN25645.1"
                     /transl_table=11
                     /translation="MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDAYPDLNE
                     ASAFDQIDKAPEERQRGITISIAHVEYQTESRHYAHVDCPGHADYIKNMITGAAQMDGA
                     ILVVAATDGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEILELVELEVRELLSEY
                     EFPGDDLPVVKVSALKALEGDAEWGQTVLDLMKAVDESIPQPERDVEKPFLMPIEDVFT
                     ITGRGTVVTGRIERGVLKVNETVDIVGIKTEKTTTTVTGIEMFRKLLDEGQAGENVGLL
                     LRGIKREDVERGQVIIKPGSVTPHTEFQAQAYILSKDEGGRHTPFFNNYRPQFYFRTTD
                     VTGVVTLPEGTEMVMPGDNTLMDVALIQPVAMEEGLKFAIREGGRTVGAGQVTKITK"
     CDS             complement(4556..5257)
                     /codon_start=1
                     /product="dehydrogenase"
                     /protein_id="QVN25646.1"
                     /transl_table=11
                     /translation="MRNDVTSMTAVLEGFTSRTPTSDGLAAERRPVPFADSVPAGPHPS
                     AEDLRPVHDLRGTLERRRSSLHYAPLPVRTDVILSLLRDVLRRDRDDWGLDTSAGALEG
                     FVFAFRSEGAEPGLYRVTAEETCYLAGLDEIGPAENLGVQREFSTGAGIVALYASLDRA
                     DTWAGSHGYRISALRASMATYDLNLRCQALGLVGTLFGGFVPSSVHHLVHSDGATRHSL
                     LATTYARPPES"
     CDS             complement(5254..6882)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /product="dehydrogenase"
                     /protein_id="QVN25647.1"
                     /sec_met_domain="PF00881 (E-value: 9.3e-08, bitscore: 22.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 2.9e-13,
                     bitscore: 40.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAEMKAEQIGRAARTDMQLTVPVRPVLRRGVRLRRAAESVVLDG
                     ADRAQVFSGAFAREGLVPLTEACDGTRDHTELALKTGFDEATVYKCLALLWTAGAVEEA
                     MSGEEPDVTPEWAVFLSRLGNSTGSNPSWADAAARLASRSVRLEGDAALVAGARRSLQE
                     VCPVVTAPAGPPGPGDELTVFFETPASAPLLAATEERCRQDGRPLLRVRADARTITIGP
                     YADLSITPCLDCGRHGEADLSGEPPEYLHDLVVGMASHHVTALLARATISHLPGDFTVI
                     DTATLSTTYRPVAVRPGCPRCSYARGPVAPQAPAGAVYEASVAMPPRAFLAPKDHQAHY
                     YASNLRLQSQFKDWPSRPHTPLPALDISVLAGSERHDPSHGDAPLTLSSLGLLLKIAFG
                     VKEDETTPERVKRWTAASGNIGSTTAYVVLRDDRIMPPGVYAYAQGSHTLVTVSGEVPP
                     GDSPCDIIITGDLKKVMTKYGTFGFRLVFLDAGCNLASLRELAQHLGLGFTPRSDWDDD
                     ALARLLGTSPADEPVAAFASLGGTA"
     CDS             complement(6898..7509)
                     /codon_start=1
                     /product="cyclodehydratase"
                     /protein_id="QVN25648.1"
                     /transl_table=11
                     /translation="MSHDPRPQCLYLVGDTFGRRLTEHRGVPPDRQVSFEDFLNDTAPH
                     ADVVVPVHAGGDSELRDETDRICAERSTPSVGLQLLPTKILCGPVVVPGRTACYACYRK
                     RAAQHAGTARPYDMDAALSGLPEGFGRQHLSVSSGLLNLALTEIATGVTGIGGTVRTFN
                     LVSGAVSSAVTVSVNRCPRCGDRFSQARADSAMPVPELLR"
     CDS             complement(7533..8879)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /product="cyclodehydratase"
                     /protein_id="QVN25649.1"
                     /sec_met_domain="TIGR03604 (E-value: 4.8e-103, bitscore:
                     335.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 2.8e-62, bitscore: 201.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLNRHQEHISAELRGLEELVSPYGLVSRTAPLPVREGEPPFAVQ
                     LAYLGVPSRALPNLRTWAHDEDTGNSDGAGTGLTPERAKLVSIAEALERYSTCAWDDDE
                     MVVAAENDLTEEFVSPSRWPSCSPTELARDDCSLTAYDPSVPIRWVRAWSLTRRIPVLV
                     PAISVYLHMPYQSKSEEFIRGITTGAAVHSDVRSAVLGGLLEVVERDAIALVWLQQLRL
                     PELVVDPARLDAGVRELHRVGTSTDLRVRLFDATTDFGVPVIYAVQLSDVDPALAQIVA
                     ATCDVHPEQALGKIYRELSSLRVALRGYLSAYAGREPDPAKVSVVGGAVHNATRDRRDV
                     FGFLLDGERPTYDLEGMPGLPAGADPLDTVVSRLAARGAEVLVTDITTDEARQVGMRAV
                     KVLVPEAMPVSFVHGERYLGTPRLYDAPRAMGHPSHAEDAVNPVQQPFA"
     CDS             complement(8926..10125)
                     /codon_start=1
                     /product="thiopeptide pyridine-forming"
                     /protein_id="QVN25650.1"
                     /transl_table=11
                     /translation="MTQITLEPGFLLLISLSYGRLQDHVTAHLAPAEISGGSFVHLFAT
                     IPQPVDSKYNDTFAPLVRELFAPERVGGTGGHGPYYFVRTQDAQLGADTLQISIEGVSD
                     EDSTRTDLHRTAERHGCAAQVDATPLDSVPSPLWNAGFTGTGFSASSKRLFQGAAPALV
                     SFLNRAAETPQSPPPALGAIHLMAAHTRATLLRSPQREIDGYEFRELLSLRLLSYRSHF
                     EAIYLRTKDPQSFDAACARFYEQVGAGVREFITACGDPDDDPADEMVRLWTKSITSESS
                     HLAESFSDGSVVNAGHTLEDLVRKRGAPVEPTRFHTPPSPELDRLMHRDADFLAFRLQT
                     SLLYSCLYTLGFSLAERYVFCYVVARANEEVCGKSMKELQDELDGLARSMASGATTTAG
                     "
     misc_feature    complement(10063..10065)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             10199..10342
                     /codon_start=1
                     /product="berninamycin precursor"
                     /protein_id="QVN25651.1"
                     /transl_table=11
                     /translation="MEQQIELDVLEISDLIAGAGENDDLAQVMAASCTTTSVSTSSSSS
                     SS"
     CDS             10666..13323
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     33; E-value: 2.3e-10)"
                     /gene_kind="biosynthetic"
                     /product="lantipeptide dehydratase"
                     /protein_id="QVN25652.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.6e-35, bitscore:
                     110.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVNISPYVVYRRSRLPLGELGGMSFTTAWSRIDELHALREEIGK
                     HAAGLADRLGELVPTLGDDVRADLIRLRRDVHNLRHDRAAARLEPLRPHLGPEVVAEVE
                     TWCALGVRAEQCERAGHEELESEKARAADGFGALFEHDAMARSIQLSGDRLYRGLRDLV
                     AGDEATALKPSKARLRESSLVNFAYRASLKPSPFGRFTEIGAFPPDDPRPADPGGRDGG
                     TQESVTTLNRLLVNWVLAGLPLVPGGMEPGHLVLNSTLRAGTEHVEFVGVAPGSREDGR
                     MATERVLRVRREGLFDALLAAMPEGSAPAATVLRDLTAVTGKAEASRKVVQGLIRAGIL
                     FFRPEIDDHDPDYSMKLDRVLAAGGTPETAALRGHFSELRRLETDFSEAAADERQKLLD
                     SAYAAIGGIAELCKVSPPPEEVLKSPVFEDTPASTAPQAWNLPTVEQSIPALTGLWRLA
                     SMMDNGQVKRLGLHSFATRVLGDRSTMPFLEFFQAFSSLTDQEQVDVFMGRDVEEAERY
                     TTQRAEALRTIRQRLVPGDDTVHLDPSVIEKACEGVEDLLDTESVTFRAQFAQGVLPDR
                     DRTLVVNGLLTGYGVYFSRFGSFVGGTDDWSLPAAQREHLARRFPGQVDLNSVLGFNFN
                     LHPSVTRRVVNYPGAVSLGAERTVYGLAGLEVRADPATRSLRLWDPEAQETLDLVPMNF
                     MTPIGVPLLYRLLEALSPSNRYLWKPLDDIRDAGGPAVYGETAPRLVVGDVVAERRSWN
                     VAAAEIPMLQDLSRDVPEALVAFDAWRLTRGLPRHAFVLCQTPEERDVMAGRSRKVTRQ
                     WADYAHLRRASVHKPMYVDFRNPFLVRSFAKSALSRGDVIASIRECLPSVDDYGPDTGW
                     TAAEEFFVELCTDN"
     CDS             13301..14260
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /product="lantipeptide dehydratase"
                     /protein_id="QVN25653.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.6e-49, bitscore:
                     157.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCVPTTSGQTGACEWRTVHIHLPHSLHTPFLCDVVEPLLRSEGL
                     QDHFFFLRYWQGGPHLRLRMLCGPGAGSADAAEQAVAGLARGMPEFGAQAREEYALGLT
                     LQDELARLEEETSGEGRPIGALDRVAYEPEYRKYGGTDGLQIAETVFRKSSVAVLGLLG
                     GQPRAWVDERRAPIGEAARIMAMFLHGAGLDPQAAGLFLREYEDWWRKYAPEDMQRAWP
                     RLFGGVSAQMTNLCAAVWRDGATDVFHDISAEAAARARSVCGAEPGGDVRDLRLDGTPY
                     PGCLSNYVHTTNNRLGLVPAAEGLVAYLVRRGLEALDG"
     CDS             complement(14381..15583)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 467.9; E-value:
                     4.2e-142)"
                     /gene_kind="biosynthetic-additional"
                     /product="P450 monooxygenase"
                     /protein_id="QVN25654.1"
                     /sec_met_domain="p450 (E-value: 8.2e-21, bitscore: 64.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDQQDSAYPYPRTCPLHPPKEYASLRAEQPITKVTLASGRTAWL
                     LTRHEHIRQLLADPHVSSNLAHPGYPLHFDAPPEVMEQMRPVLLAMDPPVHTAQRKMVI
                     PEFTVKRVLQLRPRVEEIVDECISSMLSGEGPVDLVEALALPVPSLVICELLGVPRTDR
                     AFFQDRTNKLVSVDADPQERNSAHQELHAYFSELVTAQEADPGDDLLGRLVVKNRETGT
                     FDHGELVGMANVLLVGGHETTANMISLGVVGLLENPDQLAKLRADPGLAPQAVDELLRY
                     FSIADQVTSRVATADLEIGGVLIRAGEGVIGLSASGNHDEAVFPDPDRLDIERGGRHHL
                     AFGHGIHQCIGQNLAKLELEVVFNALIARIPGLKLATPVAELPFKDSMGVYGLHKLPVS
                     W"
     CDS             15791..16252
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: thio_amide"
                     /gene_kind="biosynthetic"
                     /product="hypothetical protein"
                     /protein_id="QVN25655.1"
                     /sec_met_domain="thio_amide (E-value: 2.5e-37, bitscore:
                     117.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHSAWGCVDSTLDFVRSTSWRVRLRRRSHRVWRGGVGAMYLSIV
                     MWDLKKSEATVESLREYLRDYAVDAYSTLDGMRLKAWFSDSARQLWGAVYLWDSPEQMP
                     GLYKVSRVIDLIGYPPTSVGGFTLEATAEGKSVHETLAGLGIALEGGTR"
     CDS             16705..17415
                     /codon_start=1
                     /product="23S rRNA methyl transferase"
                     /protein_id="QVN25656.1"
                     /transl_table=11
                     /translation="MLIEDIEPLLQSIRAGVEFIEIYGLDTVPVPDSLLAECERRRIPV
                     RLLAAAVANQVFKTEKKPKVFGIAKVPRPRRLTDLSEMTGDLILLDGVKIVGNIGAIVR
                     TSFALGASGIVLVDSDLGSIADRRLIRASRGYVFSLPIVLASRAEALQYFQDNGMRPVV
                     FEADGDHTVGDLDGMDERLVLMFGSERIGPSGDFSDIAARSVSIPMNPAAESLNVSVSA
                     GIALHARARRNLSR"
     CDS             complement(17510..19588)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /product="GlcNAc-PI de-N-acetylase"
                     /protein_id="QVN25657.1"
                     /sec_met_domain="PIG-L (E-value: 2e-23, bitscore: 73.8,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDGPALPGNGVRRRTVMTMAATGAALGGCSVPTPRRTDPAPDPA
                     PGQPISTARRALLMQILAHPDDDLYFMNPDTRLALDAGTPLVCVYLTAGEADGVNKIPG
                     RARPEPDKAAYSSARHQGLRQAYAALLGLQPFTPWEVSVAELGPDHRAEVNVLAADGRR
                     VELIFLNTAMHTGRHRLGLPSLWQDRRLVLRTVVADGSPLRRAGSYTYDGLVGVLTGLM
                     ESYRPTVVHTLDPDPDIQHSTDAVRRKDSEQPGYSDHADHTAAACFAWAAMIRWVARAA
                     ADGGLIPGFVTAAYRGYYNRHWPKNLPQGVLARKAAHLVPYGGSPDWDCGNPSGCGDYN
                     VGGDRPLTNRKGWVRSTHHRYPGTRTALAAEPDGRLAAYAVLGLRVVRWQETGKDSGVW
                     GLPHDLGGGPLAPALGSATTRDGRLLLFGLRFAALGGHGADNEREIVVLEQSVPGGGFL
                     PWRGLGTPSPGRDEGRRIGVPVAVAAPDGRVHLLVRNAEKGVSTRVRDGSGRWGAWRDM
                     GGGEVQDGLGTAVDGGELVHVFGAGHHAVHHWTQDTPDAGLTARTQLTAAPVPAHAPAA
                     LPASDGSLTLHYRAAAEGGLTTVQAGAAAHVQAGTAVSGARFDGYGPVRAAPSPWGPVL
                     LGRTAEGLVQLLMGDRLHVRDGGPVALDGASLHVGPDGRPSVAGLGPDAAPWIWRPR"
     CDS             complement(19744..21228)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QVN25658.1"
                     /transl_table=11
                     /translation="MRLLIDVLDGDHATFYGPYGSRAAWHLQKLEAFRTPPRDAEAHPS
                     RWRELHDAALGRAFEISVHPGSTVAECLRRSLAEAGRRGVAGPVADALRTWLADPATDE
                     ALDQDLTVEASGLADGDLVVLCIERMPQGCYELAPAPNPAALLERMQLAMNGTAPDAGG
                     RLWGVLLYTTADTELATYVRTHFEDLDALSGPSVRVFLLERRARWADARKYWREHLEPE
                     LYRSLASMRWLRWQPYDPQGAYEVASLLKVAPELLPCLVLFNGRQDLPWGKQKVVFPVE
                     DVTPRYFRTLFGRVTEALGELPVSERGAPDDELPLGRAQGDGPAVLRDLLLRSARDRDE
                     EAFRRVSKAQQAINAALTPARPPGTGYHLNNCKVILTTGSAMTENFNFHGQNTTFVNRP
                     VNTVIQDFQNQHGTTLYADDLRQLLQLTLSSTDLPEADRAEAAQAVHDLATLSGESDAG
                     AFRLRAERLRELLSGAADVAQPALALIASVVAAVTG"
     CDS             21495..22640
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QVN25659.1"
                     /transl_table=11
                     /translation="MPPGEPANRPDGEGSVSDEQWAEIVRQAESGGADAPKEPSARARM
                     VTARLRALDEEAAAGRRRGRKNRPAEPWQPEGWRTGPTWQETHGRARKRRRLAAVLGFV
                     VVVAILVITMRPGLLTDHLPGGGDSADTGPVAGPAGVADADRPTPEEPFRGSPALHWAD
                     GAAGIELPEAAATGGMSKDEVEHALRATRQLLIAANLDPATLRGEKPDEALGLLDPLQE
                     GERERLERSLAEPSEELDPLMLFTRFDSEEARLAGDVVKTRGRMTFGAGAAGSVEVHTD
                     YTFVYPLVKPGGDEVARTIVRRKLTTALHDPERFAATRGKLSVVSSQQNVGNTDCETYD
                     GFLHPSFPSDSPHPGPAGPGVDPYDRNEWQPDGSCGKLTRT"
ORIGIN
        1 gtgcctacga tccagcagct ggtccggaag ggccggcagg acaaggtcga gaagaacaag
       61 acgcccgcgc tcgagggttc gccccagcgt cgtggtgtct gcacgcgtgt gttcacgacc
      121 accccgaaga agccgaactc ggcgctccgt aaggtcgcgc gtgtgcgtct gacctccggt
      181 atcgaggtca cggcctacat cccgggtgag gggcacaacc tgcaggagca ctccatcgtg
      241 ctcgtgcgtg gtggccgtgt gaaggacctg ccgggtgttc gttacaagat catccgcggt
      301 tcgctcgaca cccagggtgt caagaaccgc aagcaggccc gcagccgcta cggcgccaag
      361 aaggagaagt aagaatgcct cgtaagggcc ccgccccgaa gcgcccggtc atcatcgacc
      421 cggtctacag ctctcctctt gtcacctcgc tgatcaacaa gatcctgctc gacggcaagc
      481 gttccaccgc cgagcggatc gtgtacggcg ccatggaagg cctccgcgag aagaccggcg
      541 ccgacccggt catcacgctg aagcgcgcgc ttgagaacgt caagccctcg ctcgaggtca
      601 agtcccgccg tgtcggtggc gccacctacc aggtgccgat cgaggtcaag cccggtcgcg
      661 ccgccaccct cgctctgcgc tgggtcgtgg gttactcccg cgcccgtcgc gagaagacca
      721 tgaccgagcg cctcatgaac gagctgctcg acgcctccaa cggtcttggc gctgccgtca
      781 agaagcgcga ggacacccac aagatggccg agtccaacaa ggccttcgcg cactaccgct
      841 ggtagtcgct caccccatcg agaccgagag aagattgagc cttatggcca ccacttcgct
      901 tgacctggcc aaggtccgca acatcgggat catggcccac atcgacgcgg gcaagacgac
      961 caccactgag cggatcctct tctacaccgg cgtttcgtac aagatcggtg aagtccacga
     1021 cggcgcagcc acgatggact ggatggagca ggagcaggag cgcggcatca cgatcacgtc
     1081 cgccgcgacg acctgtcact ggccgctcaa tgatgttgac cacaccatca acatcatcga
     1141 caccccgggt cacgtcgact tcaccgtcga ggtggagcgt tcgctccgcg tcctcgacgg
     1201 cgccgtcacc gtgttcgacg gtgtggccgg cgtcgagccc cagtccgaga ccgtctggcg
     1261 tcaggcggac cgctacggcg tgccgcgtat ctgcttcgtc aacaagctcg accgcaccgg
     1321 cgcggagttc caccgctgcg tcgacatgat cgtgcagcgc ctcggcgcgg tcccgctcgt
     1381 catgcagctc cccatcggtg ccgaagccga cttcaagggt gtcgtcgacc tcgtgtcgat
     1441 gaaggccttc gtgtggtcgg acgaggccgc caagggcgag atgtacgaca ccgtcgagat
     1501 cccggacacc cacaaggaag ccgccgagga atggcgcggc aagctccttg aggccgtctc
     1561 ggagaacgac gaccagatga tggagctgta cctcgagggc gaagagccca ccgaggagca
     1621 gctgcacgac gcgatccgtc ggatcacgct cgcgtcgaag ggctcggccg actccgtcac
     1681 cgtgaccccc gtcttctgtg gcacggcgtt caagaacaag ggcgtccagc ccctgctcga
     1741 cgccgtcgtc cgctacctgc cttcccccct ggacgtcgag gccatcgagg gccacgacgt
     1801 caaggacgcg gagctggtcg tcaagcgcaa gccctcggac gacgagccgt tctccggcct
     1861 ggcgttcaag atcgcgagcg acccgcacct cggcaagctc accttcgtcc ggatctactc
     1921 cggtcgcctc gaggccggca ccgcggtgct gaactcggtc aagggcaaga aggagcgcat
     1981 cggcaagatc taccgcatgc acgcgaacaa gcgtgaggag atcgcgtcgg tgggcgccgg
     2041 tgacatcgtc gccgtcatgg gcctgaagca gaccaccacc ggtgagacgc tgtgtgacga
     2101 caagaacccg gtgatcctgg agtccatgga cttcccggcg ccggtcatcc aggtcgccat
     2161 cgagcccaag tccaagggtg accaggagaa gctgggtgtc gccatccagc gcctctcgga
     2221 ggaggacccc tccttccagg tgcactccga cgaggagacc ggccagacca tcatcggtgg
     2281 tatgggcgag cttcacctcg aggtgctcgt cgaccgcatg aagcgcgagt tccgcgtcga
     2341 ggcgaacgtc ggcaagccgc aggtcgcgta ccgtgagacg atccgcaagg ccgtcgagcg
     2401 catcgactac acgcacaaga agcagactgg tggtaccggc cagttcgcga aggtgcagat
     2461 cgccatcgag cccatcgagg gtggcgacgc gtcctacgag ttcgtcaaca aggtcaccgg
     2521 tggccgcatc ccccgtgagt acattccctc ggtggacgcg ggtgcccagg aagccatgca
     2581 gttcggcatc ctggccggct acgagatggt gggcgtccgc gtcacccttc tcgacggtgg
     2641 ttaccacgag gtcgactcct cggagctcgc cttcaagatc gctggttcgc aggcgttcaa
     2701 ggagggtgcc cgcaaggcgt cccccgtgct cctcgagccg atgatggccg tcgaggtcac
     2761 cacacccgag gactacatgg gtgaagtggt cggcgacatc aactcccgcc gtggccagat
     2821 ccaggccatg gaggagcgcc acggcgctcg cgtcgtgaag ggcctcgtgc ccctctcgga
     2881 gatgttcggc tacgtcggag acctccgcag caagacctcg ggtcgcgcaa gctactcgat
     2941 gcagttcgac tcctacgccg aggttccgcg gaacgtcgcc gaggagatca tcgcgaaggc
     3001 caagggcgag taactcttcc gagcacacgc tttaggcttg tcaccggagc ccggtcgggt
     3061 atgcgtcgca gtgcggcgga tgcccccggc accggcattc cagcaaagat cacctggcgc
     3121 cgatgaagca aggcgtacag aaccactcag gaggacccca gtggcgaagg caaagttcga
     3181 gcggactaag ccgcacgtca acatcggcac catcggtcac atcgaccacg gtaagacgac
     3241 cctcacggcc gccattacca aggtgctgca cgacgcgtac ccggacctga acgaggcctc
     3301 ggccttcgac cagatcgaca aggctcctga ggagcgtcag cgcggtatca cgatctcgat
     3361 cgcgcacgtc gagtaccaga cggagtcgcg tcactacgcg cacgtcgact gcccgggtca
     3421 cgcggactac atcaagaaca tgatcacggg tgcggcgcag atggacggcg ccatcctcgt
     3481 ggtcgcggcc accgacggcc cgatgccgca gaccaaggag cacgtgctcc tggcccgcca
     3541 ggtcggcgtg ccgtacatcg tcgtcgcgct gaacaaggcc gacatggtgg acgacgagga
     3601 gatcctggag ctcgtcgagc tcgaggtccg tgaactcctc tccgagtacg agttcccggg
     3661 cgacgacctt ccggtcgtca aggtctcggc gctcaaggcc ctcgagggcg acgccgagtg
     3721 gggccagacc gttctcgacc tgatgaaggc cgtcgacgag tccatcccgc agcccgagcg
     3781 tgacgtcgag aagccgttcc tcatgcccat cgaggacgtc ttcacgatca ccggtcgcgg
     3841 tacggtcgtc accggccgca tcgagcgtgg tgtcctgaag gtcaacgaga ccgtcgacat
     3901 cgtcggtatc aagaccgaga agaccaccac cacggtcacc ggcatcgaga tgttccgcaa
     3961 gctgctcgac gagggccagg ccggtgagaa cgtcggtctg ctcctccgtg gcatcaagcg
     4021 cgaggacgtc gagcgcggcc aggtcatcat caagccgggt tcggtcacgc cgcacaccga
     4081 gttccaggcc caggcctaca tcctgtcgaa ggacgagggt ggccgtcaca cccccttctt
     4141 caacaactac cgcccgcagt tctacttccg taccacggac gtgacgggcg ttgtgaccct
     4201 tcccgagggc accgagatgg tcatgccggg tgacaacacc ctcatggacg tcgcgctgat
     4261 ccagccggtc gccatggaag agggcctgaa gttcgccatc cgtgagggtg gccgtacggt
     4321 gggcgccggc caggtcacca agatcaccaa gtaattccgg ttacttgtgg gtcggggtaa
     4381 cccggttgct ctgaactgag cgcacagcac caagcagggc ccgcacggca tcacgccgtg
     4441 cgggccctgt gctgtctccg cggggctcgg ggcggacagg acgacggacg gcccgcacac
     4501 cccgagggtg tgcgggccgt cgtgacgcgg cagccgttcg cgtcggcagg cgcggtcagc
     4561 tctccggtgg ccgtgcgtac gtggtggcca gcagggagtg gcgggtcgcc ccgtcgctgt
     4621 ggaccagatg gtgcacggac gacgggacga agccgccgaa cagtgtgccg acgagcccca
     4681 gcgcctggca ccggagattg aggtcgtagg tggccatcga ggcccgcagt gcgctgatcc
     4741 ggtagccgtg ggaacccgcc caggtgtccg cccggtccag actcgcgtag agcgcgacga
     4801 tccccgctcc ggtggagaac tcgcgctgga cgccgaggtt ctcggccggc ccgatctcgt
     4861 cgagcccggc caggtagcac gtctcctcgg cggtcacccg gtacagccct ggctcggcgc
     4921 cctcgctgcg gaacgcgaag acgaagccct ccagcgcgcc cgcagaggtg tcgagccccc
     4981 agtcgtcgcg gtcccggcgc agcacgtcac gcagcagcga caggatcacg tccgtgcgta
     5041 ccggcagtgg cgcgtagtgc agcgaggagc ggcggcgttc gagcgtgccc ctcaagtcgt
     5101 ggaccggccg caggtcctcg gccgacgggt gcggtccggc gggcacggag tccgcgaacg
     5161 gcaccggccg gcgctcggcc gccaggccgt ccgacgtggg cgtccgggag gtgaacccct
     5221 ccagcacggc cgtcatggat gtcacgtcgt tcctcatgcg gtacctccca gggacgcgaa
     5281 ggcggccacc ggctcgtcgg caggcgatgt gccgagcagt cgggccaacg cgtcgtcgtc
     5341 ccagtccgac ctgggtgtga agcccaggcc caggtgctgt gcgagctccc gcagactggc
     5401 caggttgcag cctgcgtcca ggaagaccag cctgaagccg aacgtgccgt acttggtcat
     5461 gaccttcttg agatcgccgg tgatgatgat gtcgcacggc gagtcacccg gaggtacctc
     5521 gccggagacg gtcacgagtg tgtggctgcc ctgggcgtac gcgtagaccc ccggaggcat
     5581 gatccggtcg tcgcgcagca ccacgtaggc cgtcgtgctg ccgatgtttc ccgacgccgc
     5641 ggtccatcgt ttgacgcgct ccggagtggt ctcgtcctcc ttcaccccga aggcgatctt
     5701 cagcagcagt cccagggagc tcagggtgag cggggcgtcg ccgtgggacg ggtcatgccg
     5761 ttccgacccg gcgaggacgg agatgtcgag ggcggggagc ggtgtgtgcg ggcggctcgg
     5821 ccagtccttg aactgcgact gcaggcgcag gttggaagcg tagtagtgcg cctggtggtc
     5881 cttcggcgcg aggaacgcgc gtggaggcat cgcgaccgag gcctcgtaga cggcgccggc
     5941 gggtgcctgc ggtgcgaccg gcccccgcgc gtaggagcag cgagggcacc ccgggcggac
     6001 ggcgaccggc cggtaggtcg tgctcagggt cgcggtgtcg atgacggtga agtcgccggg
     6061 gaggtgcgag atcgtggccc gtgcgagcaa cgcggtgacg tggtgggagg ccatgccgac
     6121 gaccaggtcg tgcaggtact ccggcggctc gccggagagg tccgcctcac catgacggcc
     6181 gcagtccagg cagggtgtga tcgagaggtc ggcgtacgga ccgatcgtga tcgtccgcgc
     6241 gtccgcgcgc acccgcagca gcggacgccc gtcctgccgg caccgctcct cggtggcggc
     6301 gagcagtggc gcggacgcgg gcgtctcgaa gaacacggtg agctcgtccc cggggcccgg
     6361 cgggccggcc ggtgccgtga ccaccgggca cacctcctgc agcgaccggc gggccccggc
     6421 gaccagggcg gcgtccccct cgaggcgtac cgagcgcgac gccagccgcg ccgcggcatc
     6481 cgcccatgac gggttcgatc cggtggagtt gcccagccgg gagaggaaga cggcccattc
     6541 gggcgtgacg tccggttcct cgccggacat ggcctcctcg accgccccgg ccgtccacag
     6601 caaggccagg cacttgtaga ccgtggcctc gtcgaatccg gtcttgagcg ccagttccgt
     6661 gtggtcgcgg gttccgtcgc acgcctcggt caggggcacc agcccctctc gcgcgaacgc
     6721 accggagaac acctgtgccc ggtcggcccc gtcgagcacg acggattccg ctgccctgcg
     6781 cagcctcacc ccgcgtcgca ggacgggccg gacagggacg gtcaactgca tgtccgtgcg
     6841 tgcggcccgc ccgatctgct cggccttcat ctcggcaacc atgatcgatc tccctcttta
     6901 ccgcagcagt tccggaaccg gcatggcgct gtccgcgcgc gcctgcgaga accggtctcc
     6961 gcaccgcggg caccggttca ccgagaccgt caccgcggat gagacggctc cggagacgag
     7021 attgaacgta cgtacggtgc ccccgatccc cgtcacaccc gtggcgatct cggtcagggc
     7081 gaggttcagg aggccggagg agacggacag gtgctgccgg ccgaatccct cgggcaggcc
     7141 ggacagggcg gcgtccatgt cgtacgggcg ggcggtgccc gcgtgttggg cggcgcgctt
     7201 cctgtagcac gcgtagcagg ccgtccggcc cggaaccacg acgggcccgc agaggatctt
     7261 ggtcggcagc agctggagcc cgacggacgg tgtgctccgt tccgcgcaga tccggtctgt
     7321 ctcgtcgcgg agctcggagt cgccgccggc atgcacgggg acgacgacat ccgcgtgcgg
     7381 tgccgtgtcg ttcaggaagt cctcgaagga cacctgtcga tccgggggga caccacggtg
     7441 ctccgtgagc cgccggccga aggtgtcacc cacgaggtac aggcactgcg gacgcggatc
     7501 gtgcgacatg ctgctctgct ccttcttctc gctcatgcga acggctgctg cacggggttg
     7561 accgcgtcct cggcatggct cgggtgcccc atcgcgcgcg gcgcgtcata gagccgcggg
     7621 gtgccgaggt accgctcgcc gtgtacgaac gacacgggca tggcctcggg cacgagcacc
     7681 ttgaccgccc gcatgcccac ctggcgcgcc tcgtccgtgg tgatgtccgt gacgagcacc
     7741 tcggcacccc gtgccgcgag ccgggagacg acggtgtcca gcgggtccgc ccccgcggga
     7801 agccccggca tgccttcgag gtcgtacgtc ggccgttcac cgtccagcag gaagccgaac
     7861 acgtcccgcc ggtcgcgcgt cgcgttgtgg accgcgccgc cgacgacgct caccttggcc
     7921 ggatcgggct cgcgcccggc gtacgccgag aggtatccgc gcaacgccac ccgcagggag
     7981 gacagttcgc ggtagatctt gcccagcgcc tgttccggat ggacgtcgca ggtggcggcg
     8041 acgatctggg cgagcgcggg gtccacgtcg gagagctgca cggcgtagat caccgggacg
     8101 ccgaagtccg tcgtcgcgtc gaacagcctc acccgcaggt ccgtggaggt gccgacgcgg
     8161 tgcagttccc ggacgccggc gtcgagccgc gccggatcca cgaccagctc gggcagccgc
     8221 agctgctgga gccagaccag cgcgatggcg tcccgctcga cgacctccag caacccgccg
     8281 agcacggcgc tgcgtacgtc ggagtggacg gcggcacccg tggtgatccc gcggatgaac
     8341 tcttcggact tcgactggta gggcatgtgc agatacacgg agatcgccgg cacgagcacc
     8401 ggtatccgcc gggtgagcga ccatgcgcgc acccatcgga tcgggaccga cgggtcgtac
     8461 gcggtcaggc tgcagtcgtc gcgggccagc tcggtgggcg agcagctggg ccaccgggac
     8521 ggcgacacga actcctcggt gaggtcgttc tcggcggcga ccaccatctc gtcgtcgtcc
     8581 caggcgcacg tggagtaccg ttcgagcgct tccgcgatgg agaccagctt ggcgcgctcg
     8641 ggcgtgagcc cggtgcccgc gccgtcggaa tttccggtgt cctcgtcgtg ggcccacgtc
     8701 cgcaggttgg gaagcgcacg ggacgggacg ccgagatagg ccagctggac ggcgaagggc
     8761 ggttcgccct cgcgcaccgg cagcggcgcg gtgcgtgaca ccagtccgta cggcgagacg
     8821 agctcctcga gaccgcgcag ctcggccgag atgtgctcct gatgcctgtt cagatgcatg
     8881 tggttcttct tcctgcgtcc ggatgttccc cgtgcccctg ccgcgctacc cggcggtcgt
     8941 cgtggctccc gacgccatgc tcctggccag gccgtcgagc tcgtcctgga gctccttcat
     9001 ggacttgccg cagacctctt cgttcgcacg tgcgacgacg tagcagaaga cgtacctctc
     9061 cgccaggctg aaaccgaggg tgtacaggca gctgtacagc aggctggtct gcagccggaa
     9121 ggccaggaag tcggcgtcgc ggtgcatgag gcggtccagc tcggggctcg gcggcgtatg
     9181 gaagcgcgtc ggttcgaccg gggcgcctcg cttgcgaacg aggtcttcga gcgtgtgtcc
     9241 ggcattgacg acggatccgt ccgagaagct ttcggccagg tggcttgatt cagacgtgat
     9301 ggatttcgtc caaagtcgaa ccatctcgtc ggccgggtcg tcgtccggat cgccgcacgc
     9361 cgtgatgaat tcccggacgc cggcccctac ctgttcatag aaacgggcgc aggcggcgtc
     9421 gaaggattgt ggatccttgg tgcgaagata aatcgcctcg aaatgcgaac ggtagctcag
     9481 caagcgcagg gagagcagct cgcggaattc gtatccgtcg atttctctct gcggagatct
     9541 caggagggtg gctctggtgt gcgcggccat gaggtggatg gcaccgagtg ccggcggagg
     9601 cgattgaggt gtctctgccg cacgattcaa gaatgagacg agagccggtg cggctccctg
     9661 gaagagccgc ttggaggaag cggagaatcc ggttccggta aagcccgcgt tccacagcgg
     9721 cgagggaacc gaatcaagtg gcgttgcgtc tacctgtgcg gcgcacccgt gtcgctcggc
     9781 cgttctatgc aggtcagtgc gggtggagtc ctcgtcggac accccttcga tgctgatctg
     9841 cagggtgtcc gcgccgagct gcgcgtcctg ggtacggacg aagtagtagg ggccgtgacc
     9901 gcccgttccg cctacccgct ccggcgcgaa caattcgcga accaggggcg cgaacgtgtc
     9961 gttgtatttt gaatcaactg gctgcgggat ggtggcaaac aagtgcacga atgaaccccc
    10021 cgagatttcg gccggcgcca gatgggccgt cacgtgatct tgtaatcgac cgtaactcag
    10081 agagatgaga agaaggaacc ccggctccag tgtgatctgc gtcacttcgg aaactgcttg
    10141 cgttgtgatc gtccgaatgc ctagattcga agcacattga cgaaaggggg tgtaatcaat
    10201 ggagcagcag atcgaactcg atgtgctcga gatttcggac ctcattgcag gtgccgggga
    10261 gaacgatgac ctggcgcagg tgatggccgc ctcgtgcacg accaccagtg tttcgacgag
    10321 ttcttcgtcg tcctcgtcct gaatctaggg accgggaaac agttgagcca ccgtcggggt
    10381 gttcctcggc ggtggccttc tgcagtcctg gcgcgccttt tcgattcgag gaatcgcgcc
    10441 gtccctggag gtgcgaccag gggtgcgggc gtcgcgcccc ggacgacgac gggctcgtgc
    10501 gacgccggcc ggtcgtgtac cggcacacat gttgtcaagc gcgaactgac cggttcggcg
    10561 gagcgacagg cgggctccgt gtggcggggc gcctctccgc gacccggccc cgatgtccgc
    10621 acgccgtggt gaaccgggcc ggcgtgacga agttggggga ttcctatggg tgtgaacatc
    10681 agtccgtacg tcgtctatcg acgcagcaga ctcccactgg gcgagctcgg agggatgtcc
    10741 ttcaccaccg cctggtcgcg catcgatgaa ctgcacgccc tgcgggagga gatcggcaag
    10801 cacgccgccg gtctggccga ccgcctcggc gagctcgtgc cgacgctggg ggacgacgtc
    10861 cgggccgacc tgatcaggct gcggcgcgac gtgcacaatc tgcggcacga ccgggcggcg
    10921 gcgcgactgg agccactccg tccgcatctc ggccccgagg ttgtcgccga ggtcgagacc
    10981 tggtgcgcgc tcggcgtccg ggccgagcag tgcgagcgag cagggcacga ggagctcgag
    11041 agcgagaagg cccgggccgc cgacggcttc ggcgccctct tcgagcacga tgcgatggcc
    11101 cgcagcatcc agctctccgg cgaccggctg taccggggcc tgcgcgacct cgtcgcgggc
    11161 gacgaggcga ccgccctcaa gccgagcaag gcccggctgc gggagtcctc cctcgtcaac
    11221 ttcgcctacc gggcgagctt gaagccgtcc cccttcggac ggttcaccga gatcggcgcg
    11281 ttccctccgg acgacccgcg ccccgcggac cctggtggcc gggacggcgg gacgcaggag
    11341 tcggtcacga cgctgaaccg tctcctcgtg aactgggtgc tcgccggatt gccgctcgta
    11401 ccgggcggga tggagccggg gcacctcgtg ctgaactcca ctctgcgggc cggcacggag
    11461 cacgtcgaat tcgtcggtgt cgctcccggc tcccgcgagg acggccggat ggccaccgag
    11521 agggtgctgc gcgtacgccg ggagggactc ttcgacgcac tgctcgcggc gatgcccgaa
    11581 ggatcggctc cggcggccac ggtgctgcgc gacctcaccg ccgtcaccgg gaaggcggag
    11641 gcgagccgga aggtcgtgca ggggctgatc cgggccggca tcctgttctt ccggccggag
    11701 atcgacgatc acgaccccga ctactccatg aagctcgacc gcgtactcgc cgccggcggg
    11761 acgccggaga cggccgcgct acgcggacac ttctccgaac tcaggcggct ggagacggac
    11821 ttctccgagg cggcggccga cgagaggcag aagctgctcg actcggcgta cgcggcgatc
    11881 ggcggcatcg ccgagctgtg caaggtgtcc ccgccccccg aggaggttct gaagtcaccg
    11941 gtcttcgagg acactccggc atccacggcg ccccaggcct ggaacctgcc gacggtggag
    12001 cagagcatcc ccgccctgac gggcctctgg cgcctggcct cgatgatgga caacggccag
    12061 gtgaagcggc tgggtctcca ctccttcgcc acccgcgtgc tcggcgaccg cagcacgatg
    12121 cccttcctcg agttcttcca ggccttctcg tcgctgacgg accaggaaca ggtcgacgtg
    12181 ttcatggggc gcgacgtgga ggaggccgag aggtacacga cgcagcgggc ggaggctctg
    12241 cgcacgatcc ggcagcggct cgtgcccggg gacgacaccg tgcacctgga cccctcggtc
    12301 atcgagaagg cctgcgaggg cgtggaggac ctcctcgaca cggaatcggt gacgttccgt
    12361 gctcagttcg cccagggcgt gctgcccgac cgggaccgga cgctggtcgt gaacggcctg
    12421 ctcaccggct acggcgtcta cttctcacgg ttcggctcgt tcgtcggggg caccgacgac
    12481 tggtccctgc cggccgccca gcgggagcat ctcgcacgca ggttccccgg ccaggtcgac
    12541 ctcaactccg tgctcggctt caacttcaac ctgcacccct cggtgacccg gcgggtcgtc
    12601 aactaccccg gcgcggtgtc gctcggcgcc gagcggacgg tttacggact ggcaggtctg
    12661 gaggtccgcg cggatcccgc caccaggtcg ctgcgcctct gggacccgga ggcgcaggaa
    12721 accctcgacc tcgtgcccat gaacttcatg accccgatcg gggtcccact gctctaccgt
    12781 ctgctcgagg cgctgtcccc gtccaaccgc tacctgtgga agcccctgga cgacatcagg
    12841 gacgcgggag ggcccgcggt gtacggcgag acggcacccc gcctggtcgt gggtgacgtc
    12901 gtggccgagc gcaggtcctg gaacgtggcc gcggccgaga tccccatgct ccaggatctg
    12961 agccgggacg tgcccgaagc gctcgtggcc ttcgacgcgt ggcgcctgac acggggcctt
    13021 ccccgccacg ccttcgtact gtgccagacg cccgaggaac gtgacgtcat ggccgggcgc
    13081 agccggaagg tgacccgcca gtgggcggac tacgcgcacc tgcggcgcgc cagcgtccac
    13141 aagccgatgt acgtcgactt ccggaacccc ttcctggtcc ggagtttcgc gaagtcggcc
    13201 ctgtcacgcg gcgatgtcat cgcgtcgatc cgcgagtgcc ttccttcggt ggacgactac
    13261 ggcccggaca cgggctggac cgcagcagag gagttcttcg ttgaactgtg taccgacaac
    13321 tagtgggcag accggagcgt gtgagtggag gacggtccac atccaccttc cgcactcgct
    13381 gcacaccccc ttcctgtgcg acgtggtcga gccgctgctc cgctccgagg ggctccagga
    13441 ccacttcttc ttccttcggt actggcaggg cggcccccat ctgcggctgc ggatgctctg
    13501 cggccccggg gccggttcgg ccgatgcggc cgaacaggcc gtcgccggtc tggcacgtgg
    13561 gatgccggag ttcggtgcgc aggcgcggga ggaatacgcg ctcgggctga ccttgcagga
    13621 cgagctcgcc cgcctggagg aggagacctc gggggagggc cggcccatcg gggccctcga
    13681 ccgggtggcc tacgagccgg agtaccgcaa gtacggggga acggatgggc tgcagatcgc
    13741 cgagaccgtc ttccggaagt cgtcggtggc ggtcctcggc ctgctgggcg ggcaaccgcg
    13801 ggcgtgggtc gacgagcgcc gggcaccgat cggggaagcc gcgaggatca tggcgatgtt
    13861 cctccacggg gcaggtctcg acccgcaggc cgcagggctg ttcctgcggg agtacgagga
    13921 ctggtggcgt aagtacgcgc cggaggacat gcaacgtgcc tggccgagac tcttcggcgg
    13981 cgtctcggca cagatgacga atctgtgcgc ggccgtctgg cgcgacggcg ccacggacgt
    14041 gttccacgac atcagcgcgg aggccgccgc ccgcgcccgt tccgtgtgcg gggcggagcc
    14101 cggcggcgat gtccgcgacc tccggctcga cggcacgccg tatccgggct gtctctccaa
    14161 ctacgtgcac acgaccaaca accgtctcgg cctggtcccc gccgccgaag ggctcgtcgc
    14221 gtacctcgtg cgccggggcc tggaagcact ggacggttag ggcctgtcgt tgtcgggatc
    14281 acgctgtgcc cctgtgcccc ggtgccggaa gcccgaagcc tccgtcccgc gcaggccctt
    14341 ccctgtggga cccgcgccgg acggagagct catcggtgcg tcaccagctc accggaagct
    14401 tgtgcaggcc gtacaccccc atgctgtcct tgaacggcag ttccgcgacc ggggtggcca
    14461 gcttcaggcc gggaatcctc gcgatgaggg cgttgaagac gacctccagc tccagcttgg
    14521 cgaggttctg gccgatgcac tgatggatgc cgtggccgaa cgccaggtgg tgcctgccgc
    14581 cgcgctcgat gtcgagcctg tccgggtcgg ggaacaccgc ctcgtcgtgg ttgcccgagg
    14641 cgctgagccc gatgacgcct tcacccgcgc ggatcagcac tccgccgatc tcgaggtcgg
    14701 ccgtcgccac ccgggaggtc acctggtcgg cgatgctgaa gtagcgcagc agctcgtcga
    14761 cggcctgagg ggccagaccc gggtcggccc tgagcttggc cagctggtcg gggttctcca
    14821 gcaggcccac gacgccgagg gagatcatgt tcgcggtggt ctcgtgaccg ccgaccagga
    14881 ggacgttcgc catcccgacc agttctccgt ggtcgaacgt gccggtctcg cggttcttca
    14941 cgacgagccg gccgagcagg tcgtcccccg ggtccgcttc ctgagcggtg accagctcgg
    15001 agaagtacgc gtggagctcc tgatgcgcgc tgttgcgctc ctgcgggtcg gcgtcgaccg
    15061 acaccagctt gttggtgcgg tcctggaaga acgcgcggtc ggtgcgcggc accccgagca
    15121 gctcgcagat caccagggac ggcaccggga gggcgagcgc ctcgaccaga tcgaccggcc
    15181 cctcgccgga gagcatggag gagatgcact cgtccacgat ctcctcgacg cggggacgca
    15241 gttggagcac ccgcttgacg gtgaactccg ggatcaccat cttgcgctgc gccgtgtgta
    15301 caggcgggtc catggcgagc agcacgggcc gcatctgctc catgacctcc ggcggcgcgt
    15361 cgaagtggag cggatagccc gggtgggcca ggttcgagct cacatggggg tcggcgagca
    15421 actgtcgtat gtgctcgtgc cgggtgagga gccacgcggt ccgcccggag gccagagtga
    15481 ccttggtgat cggctgctcg gcacgcaggg acgcgtactc cttcggcggg tggagcgggc
    15541 aggtccgggg gtaggggtac gcgctgtcct gttggtccgt cacggtgttc tccgcgggta
    15601 gttcagggaa atctccttac ggaccccatt caagcggaag gtgatccaca tcgtggcgtt
    15661 atcggtgaat gaggccgaac tcacctggac cgcaacagga aagccgaccg ccttccccgc
    15721 atggtccgtg ccgtgctttc ggtacagggg gtcggtacag tgcggcattg cagtcaccac
    15781 gccatccgga atgacccatt ccgcgtgggg atgcgttgat agtacgttgg atttcgtgcg
    15841 ctccacatcg tggagagttc gcttgcgccg tcgaagtcac cgtgtgtggc gagggggagt
    15901 tggagctatg tacctttcga tcgtcatgtg ggatctgaag aagtcggaag ccacggtgga
    15961 gagtctcagg gaatacctgc gggactatgc cgtggacgcc tactccacgc tggacggaat
    16021 gcggctcaag gcgtggttct ccgattccgc acgccagttg tggggtgcgg tctatctgtg
    16081 ggacagcccc gagcagatgc ccggcctgta caaagtcagc cgcgtgatcg acctcatcgg
    16141 gtatccgccg acttcggtcg gtggtttcac gctcgaggcg accgccgaag ggaagagcgt
    16201 ccacgagact ctggccggcc tggggatcgc cctggagggc ggaacgcggt aggggcaggc
    16261 gtgcgacggg gcgggcgggg gacttgcccg acccgtcggt tcgaggggcg gtcgagggcc
    16321 ggagccgcgg gtggctgcgc cgctccggct ggaggccggg tgtggcgtgt cgcgcggcgc
    16381 aggtgtcgcc cgagcctggc gtcaccgtgc tcgcagaggg gtcaggtctg tcggaccggc
    16441 gctttcgcgt gtgctcggca tcgtccggtg ggccggggcg ctgtgcgcgg gcgtcgggct
    16501 cctgggtggg ggtgcggtgt gccggccccc gcccggacac gcgtattcgg caccgcttca
    16561 cgaagatcat tcggtgaagg aggcgggagc gctcgtgcta acgtcgtgat cgtggccagc
    16621 cttgacatta ttaccgaacg ctctgattct gccgtacaac gcatcatcga tgtgacaaag
    16681 cattcgaggt ccgttgtccg cacggtgctg atcgaggaca tcgagcctct tctgcagagc
    16741 atccgtgccg gagtggaatt catcgagatc tacgggctcg acaccgtgcc tgttccggac
    16801 agtctgctcg ccgaatgtga acggcgcaga attccggtcc ggctgctcgc cgctgcggtc
    16861 gccaatcagg tcttcaagac cgagaagaag cccaaggtat tcggtatcgc caaggttccg
    16921 cggcctcgtc gcctgacgga cctgtccgag atgaccggtg acctcatcct cctcgacgga
    16981 gtgaagatcg tcggaaatat cggagccatc gtgcggacct cgttcgcgct cggggcttcg
    17041 ggaatcgtcc tcgtggacag cgatctcggc agcatcgcgg accgccgtct gatcagggcg
    17101 agccggggct atgtgttctc ccttccgatc gtcctcgcgt cccgggccga agcgctccag
    17161 tacttccagg acaacggcat gcgcccggtg gtcttcgagg ccgacgggga tcacacggtc
    17221 ggtgatctgg acggcatgga cgagcgcctt gtcctcatgt tcggcagcga gaggatcggc
    17281 ccgtcgggcg atttctcgga tatcgccgcc agatcggttt ccattcccat gaatcctgcg
    17341 gccgagtcgc tcaacgtctc ggtgtccgcc gggatcgcgc tgcacgcgcg agcccgtcgt
    17401 aatctctccc ggtagtcccg gccgtagaac ggtgccacgg gcctcgcccc ctcccggaag
    17461 ggggacgagg cccttggccg tacgcggcgg tggaccaccg gccgcgcctc taccggggcc
    17521 gccatatcca gggcgccgca tccggaccga gaccggcgac cgagggccgg ccgtccgggc
    17581 ccacgtggag cgaggccccg tccagggcga ccggaccgcc gtcccgtacg tgaagcctgt
    17641 cgcccatgag tagttggacg aggccctcgg cggtgcggcc gagcagtacg ggcccccacg
    17701 gtgacggggc ggcgcgcacc ggcccgtacc cgtcgaaccg cgctccggac acggccgtcc
    17761 cggcttggac gtgcgccgcc gccccggcct gaacggtcgt cagcccgccc tcggccgccg
    17821 cccggtagtg gagcgtgagc gacccgtcgg acgccggtag ggcggcgggt gcgtgtgccg
    17881 ggacgggcgc cgccgtgagc tgcgtgcggg cggtgagccc ggcgtccggc gtgtcctggg
    17941 tccagtggtg caccgcgtgg tggccggcgc cgaagacatg gaccagctcg cccccgtcca
    18001 cagctgtgcc caggccgtcc tgcacctcgc cgccacccat gtcccgccac gcgccccacc
    18061 gccccgaccc gtcccgcacc cgggtgctga cgcccttctc cgcgttgcgt acgaggagat
    18121 ggacccgccc gtccggagcg gcgacggcca ccggtacgcc gatgcgccgc ccctcgtcac
    18181 gcccgggaga aggagtgccg aggccgcgcc acgggagaaa gccgccgccc gggacgctct
    18241 gctccagcac cacgatctcg cgctcgttgt cggcgccgtg cccgccgagc gcggcgaagc
    18301 ggagcccgaa cagcagcagg cgcccgtccc gtgtcgtggc cgaacccagt gcgggggcga
    18361 gcggcccgcc gccgaggtcg tgcggaagac cccacacgcc gctgtccttc ccggtctcct
    18421 gccaccgcac cacccgcagt ccgagcacgg cgtaggccgc gagccggccg tccggctcgg
    18481 cggcgagggc cgtgcgcgtg cccgggtagc ggtggtgggt ggagcggacc cagcccttgc
    18541 ggttggtcag cgggcggtcg ccgccgacgt tgtagtcacc gcagccggac ggattgccgc
    18601 agtcccagtc gggcgagccc ccgtagggga cgaggtgggc cgccttcctc gccagcaccc
    18661 cctgcggcag gttcttcggc cagtgccggt tgtagtaacc gcggtaggcg gccgtcacga
    18721 aacccggtat caggccgccg tccgcggccg cccgggccac ccagcggatc atcgccgccc
    18781 acgcgaagca ggccgcggcc gtgtggtccg cgtggtcgga gtagccgggc tgttcgctgt
    18841 ccttgcggcg gacggcgtcc gtgctgtgct ggatgtccgg gtcggggtcc agggtgtgga
    18901 cgacggtggg ccggtagctc tccatcaggc cggtgaggac cccgaccagc ccgtcgtacg
    18961 tgtacgagcc ggcgcgccgc agcggtgaac cgtcggccac gaccgtacgc agcaccagcc
    19021 ggcggtcctg ccagaggctg ggcagcccga gccggtgccg cccggtgtgc atggccgtgt
    19081 tgaggaagat cagttccacc cggcggccgt cggcggccag cacgttcacc tcggccctgt
    19141 ggtccgggcc gagctcggcg acggagacct cccagggcgt gaacggctgc agcccgagca
    19201 gggcggcgta cgcctgtcgc agcccctggt ggcgtgcgga ggagtacgcg gccttgtccg
    19261 gctccgggcg ggcgcggccg gggatcttgt tgacgccgtc ggcctcaccg gccgtgaggt
    19321 agacgcatac cagcggtgtc ccggcgtcga gggcgagccg ggtgtccggg ttcatgaagt
    19381 acaggtcgtc gtccgggtgg gcgagtatct gcatcagcag cgcccgccgc gcggtgctga
    19441 tgggctgccc gggcgcggga tccggggcgg gatccgtacg ccggggcgtg gggaccgagc
    19501 agcccccgag cgccgcaccc gtggcggcca tggtcatgac ggtgcgccgg cgcacaccgt
    19561 ttccgggcag ggcaggtcca tccgtcacgc cacgcactcc gtccgcgtcc ccccgcagcg
    19621 gacgggcgtg tgcccagagc tgcgtgctgt cggtcagcgc aggtcagggc ttgcgcctgc
    19681 tcctgcgggg ggatagacgg ggatccgggc ccgcgcgttg cccggacggc cgggcaacgc
    19741 gtgctatccg gtcacggcgg cgacgaccga ggcgatgagg gccagcgcgg gctgggcgac
    19801 gtcggccgcg ccggagagca gctcccgcag gcgttccgcg cgcaggcgga aggcgccggc
    19861 gtcggactcc ccggacagcg tggccaggtc gtgcacggcc tgggcggcct cggcgcggtc
    19921 ggcctcgggc aggtcggtgc tcgacagggt cagctggagg agctgtcgca ggtcatcggc
    19981 gtacagggtg gtgccgtgct ggttctggaa gtcctggatg accgtgttca cgggacggtt
    20041 gacgaacgtg gtgttctgcc cgtggaagtt gaagttctcc gtcatggcgc tccccgtggt
    20101 gagaatgacc ttgcagttgt tcaggtggta cccggtgcct ggcgggcgag ccggtgtcag
    20161 agcggcgttg atggcctgtt gggccttcga gacccttctg aacgcctcct cgtcgcggtc
    20221 ccgggcgctg cggagcagca ggtcgcgcag taccgcgggg ccgtcgccct gagcccggcc
    20281 gagcggcaac tcgtcgtccg gagcgccgcg ttcggacacg ggcagctcgc cgagggcctc
    20341 ggtgacgcgg ccgaagagcg tgcggaaata gcggggcgtg acgtcctcga cggggaacac
    20401 gaccttctgc ttaccccagg ggaggtcctg tctgccgttg aacaggacga gacagggcag
    20461 cagttcgggg gccaccttga ggagggaggc cacctcgtag gcaccctgag ggtcgtacgg
    20521 ctgccagcgc agccagcgca tggacgccag gctccggtac agctccggct cgaggtgctc
    20581 gcgccagtac ttcctggcgt cggcccaccg agcccggcgc tccaggagga acacacggac
    20641 ggaagggccc gacagggcgt cgaggtcctc gaaatgcgtg cggacgtagg tcgccagctc
    20701 ggtgtcggcg gtggtgtaga ggaggacgcc ccacagcctg cccccggcgt cgggcgcggt
    20761 cccgttcatg gccagctgca tgcgttccag caaggcggcc ggattgggtg cgggggccag
    20821 ctcgtagcag ccctggggca tgcgctcgat gcacaggacg accaggtcgc cgtcggccag
    20881 gccggacgcc tcgacggtga ggtcctggtc gagtgcctca tccgtggccg ggtccgccag
    20941 ccaggtgcgc agcgcgtcag ccaccggtcc ggccacgccc ctccgcccgg cttcggccag
    21001 ggaccgcctc aggcattcgg cgaccgtcga ccccgggtgg accgagatct cgaacgcccg
    21061 gcccagcgcg gcgtcgtgca gctcccgcca cctggacgga tgggcttcgg cgtcccgggg
    21121 cggagtacgg aacgcttcga gcttctggag gtgccaggcc gctctgctgc cgtaggggcc
    21181 gtagaacgtg gcgtgatccc cgtcgagtac gtcgatcagc aggcgcacgg cgtctccccc
    21241 ggtggacgtg tggtccctgt gagtctccgt tgcggccgtc gccgggcgca agcggccgcg
    21301 tccgccggac gagggaccgt gcgacaagtc cgctgccggc gggccgggtt cggtcaccgc
    21361 ggccagtctc aggcacacat ccatcacgtg atcattacgg tttgcttcgc actcttgtcc
    21421 gaatgtgggc cgacgacgtg aagtagtgcc gccagagctg tgtgggggag tggaagagga
    21481 cagtgagcag cgacatgcca ccgggggagc ccgccaaccg tccggacgga gagggctccg
    21541 tctccgacga acagtgggcg gagatcgtcc ggcaggccga gagcggtggg gccgacgcgc
    21601 ccaaggagcc ctcggcccgc gcccggatgg tcacggcgcg gctgcgcgcg ctggacgagg
    21661 aggcggcggc cgggcggcgc cggggccgga agaacaggcc ggccgaaccc tggcagcccg
    21721 aggggtggcg taccggcccc acctggcagg agacgcacgg ccgcgcacgg aagcggcggc
    21781 gtctcgccgc ggtcctgggg ttcgtggtgg tcgtggcgat cctggtgatc accatgcggc
    21841 cgggcctgct gaccgaccac ctgccgggag ggggcgactc cgcggacacc gggcccgtcg
    21901 ccgggcccgc cggagtggcg gacgcggacc ggccgacgcc ggaggagccc ttccgtggtt
    21961 cgcccgcgct ccactgggcg gacggggcgg cggggatcga gctcccggag gccgcggcga
    22021 ccggagggat gagcaaggac gaggtcgagc acgccctgcg ggcgacccgg cagctgctca
    22081 tcgccgccaa cctcgatccg gccaccctgc ggggggagaa gcccgacgag gcgctggggc
    22141 tgctcgatcc gctgcaggag ggggagcggg agcggctcga gcggtccctg gcggagccga
    22201 gcgaggagct ggacccgctg atgctgttca cccggttcga ctcggaggag gcccggctcg
    22261 ccggggacgt cgtcaagacg cgggggcgga tgacgttcgg agcgggcgct gccggctcgg
    22321 tcgaggtgca caccgactac accttcgtct acccgctggt gaagccgggc ggagacgagg
    22381 tggcgcgcac gatcgtgcgg cggaaactga cgaccgcgct gcacgacccg gagcggttcg
    22441 cggcgacgcg cggcaagctc tccgtcgtca gttcccagca gaacgtcggc aacaccgact
    22501 gcgagaccta cgacggtttc ctgcacccct ccttcccgag cgacagcccg caccccggcc
    22561 ccgccgggcc cggcgtcgac ccctacgacc gcaacgagtg gcagcccgac ggctcctgcg
    22621 ggaagctcac ccgtacgtga
//
