LOCUS       BGC0002366             23000 bp    DNA     linear   BCT 23-FEB-2020
DEFINITION  Streptomyces sp. SCSIO 11863 enterion biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0002366
VERSION     BGC0002366
KEYWORDS    .
SOURCE      Streptomyces sp. SCSIO 11863
  ORGANISM  Streptomyces sp. SCSIO 11863
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:26:25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 23000
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..23000
                     /db_xref="taxon:1333476"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. SCSIO 11863"
                     /strain="SCSIO 11863"
     misc_feature    1..23000
                     /note="enterion biosynthetic gene cluster"
     subregion       1..23000
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..23000
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(953..1939)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 250.7; E-value:
                     3.4e-76)"
                     /gene_kind="transport"
                     /note="efflux protein"
                     /product="EncT"
                     /protein_id="QIC03929.1"
                     /transl_table=11
                     /translation="MAIWTAVSSAGGAAGNLIGGVLTDALSWRWILLINVPIGTVAVLA
                     ALRLLPSDRSRAVSGRLDVPGAVLATLGVTALVYGVNQAGTQGWTGATTLTGLAVSAVA
                     LTAFAVTESRYTAAPLMPPRLVRLRPIWAGNVTMLLAGGCFIPMWYFLSLYMQEVLHYG
                     ALATGVGFLPHTLVGIAAARLAPAVMERTGARGLIVLSAVLSAVGFLWQSSISTDSGYL
                     DGLLGPAIVMSAGMGLLITPITTTVTSGIREQDAGAASGLMNTTRQLGGVVGLAALVTL
                     ATADGGPDLSYRAVFVATAAVCAGVAVMALALPAPQEGRDESVAMRR"
     CDS             2477..3124
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 130.6; E-value: 1.5e-39)"
                     /gene_kind="regulatory"
                     /note="regulatory protein"
                     /product="EncS"
                     /protein_id="QIC03930.1"
                     /transl_table=11
                     /translation="MPKRVDHAQRRAHIADALVRVAARDGLHAVTMRAVAAEAGMSLNL
                     VQYYFDTKAQLMHAALQHLEQQSHERWSARLESLEDPGSARACLEAFVDEALPVDADSH
                     TFRLVWTSYAVLAMTDPELAEQPFVEGPNRLERQLTHILATAQAAGEIAAYLDVSAEAA
                     RLLSLSHGVGTSVLVGQRSAAQARYVMLYHLSRLFNDPTPPEAPGQHLAAAS"
     CDS             3217..4422
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 453.9; E-value:
                     7.3e-138)"
                     /gene_kind="biosynthetic-additional"
                     /note="p450 monooxygenase"
                     /product="EncR"
                     /protein_id="QIC03931.1"
                     /sec_met_domain="p450 (E-value: 3e-25, bitscore: 79.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHTQQLWDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGEA
                     WLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVAGV
                     FTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDDREQ
                     LRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRCQPTDDLLGALVQTWDREEGL
                     LRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPAAMASAVEELLRF
                     IPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDIDRSPNPH
                     VAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVRGPKTLPV
                     KW"
     CDS             4416..4661
                     /codon_start=1
                     /note="ferredoxin"
                     /product="EncQ"
                     /protein_id="QIC03932.1"
                     /transl_table=11
                     /translation="MVTGESAAAGRWRLAVDATLCIGSGACAGSSAHFRMTQDGHAEPR
                     EDVIVADDTARDAAECCPVEAITVSDTSTGELIAPT"
     CDS             4966..6537
                     /codon_start=1
                     /note="phenylalanine ammonia lyase"
                     /product="EncP"
                     /protein_id="QIC03933.1"
                     /transl_table=11
                     /translation="MTLVIDLDMNVTLDQLEDAARQRTPVELSAPVRSRVRASRDVLEK
                     FVQDERVIYGVNTSMGGFVDHLVPVSQARQLQENLINAVATNVGAYLDDTTARTIMLSR
                     IVSLARGNSAITPANLDKLVAVLNAGIVPCIPEKGSLGTSGDLGPLAAIALVCAGQWKA
                     RYNGQIMPGRQALSEAGVEPMELSYKDGLALINGTSGMVGLGTMALQAARRLVDRYLQV
                     SALSVEGLAGMTKPFDPRVHGVKPHRGQRQVASRLWEGLADSHLAVNELDTEQTLAGEM
                     GTVAKAGSLAIEDAYSIRCTPQILGPVVDVLDRIGATLQDELNSSNDNPIVLPEEAELF
                     HNGHFHGQYVAMAMDHLNMALATVTNLANRRVDRFLDKSNSNGLPAFLCREDPGLRLGL
                     MGGQFMTASITAETRTLTIPMSVQSLTSTADFQDIVSFGFVAARRAREVLTNAAYVVAF
                     ELLCACQAADIRGADKLSSFTRPLYERTRTIVPFLDRDETITDYVEKLAADLIAGEPVD
                     AAVAAH"
     CDS             6564..6956
                     /codon_start=1
                     /note="hypothetical protein"
                     /product="EncO"
                     /protein_id="QIC03934.1"
                     /transl_table=11
                     /translation="MTTTLAEQAVTDFVREWSTAEERGEHRALDDLLAKDFVGVGPQGF
                     VRSREEWLARYSTGTVRNTSFEVSDLRIRSYGETAVVVAAQTQQSVNGDADASGAFRFT
                     LIVVRQDGRLRLAGLHLSPNAVPAGG"
     CDS             complement(6998..8566)
                     /NRPS_PKS="Domain: AMP-binding (20-415). E-value: 6.4e-92.
                     Score: 300.1. Matches aSDomain:
                     nrpspksdomains_QIC03935.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     355.1; E-value: 8.3e-108)"
                     /gene_kind="biosynthetic-additional"
                     /note="aryl-CoA ligase"
                     /product="EncN"
                     /protein_id="QIC03935.1"
                     /sec_met_domain="AMP-binding (E-value: 1e-98, bitscore:
                     320.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDLFNLSTLVDHHLDSGLSDKAALYSPHGHVSYGELYRSMCAM
                     GRALRELGIQREQRVLLILDDTPAFFTAFLGAGRIGAVPVPINYQTDPEQVRFYAQDSY
                     ARAAVIEADRYEELAPALQEAGVMVISTEPAGPDDGRFHMRDLIRGHEGELGAASTHAE
                     DPALWLYSSGSTGRPKGVVHLQRDIAPACRHYAGDVLGVTQDDVHLSTTKLFHAYGLGN
                     SLLFPLWFGGTCVLLPGFPAPHLVLETIERVRPTLLFSVPALYNAMPRSPGAGSRDLTS
                     IRLCVSAAESLPAHVWERWRDLYGLTILDGVGSTEMLHIYCSNTERALRPGSSGRAVPG
                     YQIKLVDPDGGNVEGAGSGEMFVRGGSMLAQYWHRADQTRSVLKGSWYRTGDRCRRDED
                     GFYWYEGRADDMMKVSGLWVAPAAIETALQQHPDVAEAAVVGVDTDRLTRIKAFIVLRD
                     GCQGSDALARQLRQWCKDRLASHQFPHLVEFAADLPKTPTGKIQRFALRSQETGKADAP
                     AAHAV"
     CDS_motif       complement(7292..7354)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03935.1_0002"
                     /evalue="6.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="QIC03935.1"
                     /protein_end="425"
                     /protein_start="404"
                     /score="12.5"
                     /tool="antismash"
                     /translation="EGRADDMMKVSGLWVAPAAIE"
     aSDomain        complement(7322..8506)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03935.1_AMP-binding.1"
                     /evalue="6.40E-92"
                     /label="QIC03935.1_AMP-binding.1"
                     /locus_tag="QIC03935.1"
                     /protein_end="415"
                     /protein_start="20"
                     /score="300.1"
                     /tool="antismash"
                     /translation="SDKAALYSPHGHVSYGELYRSMCAMGRALRELGIQREQRVLLILD
                     DTPAFFTAFLGAGRIGAVPVPINYQTDPEQVRFYAQDSYARAAVIEADRYEELAPALQE
                     AGVMVISTEPAGPDDGRFHMRDLIRGHEGELGAASTHAEDPALWLYSSGSTGRPKGVVH
                     LQRDIAPACRHYAGDVLGVTQDDVHLSTTKLFHAYGLGNSLLFPLWFGGTCVLLPGFPA
                     PHLVLETIERVRPTLLFSVPALYNAMPRSPGAGSRDLTSIRLCVSAAESLPAHVWERWR
                     DLYGLTILDGVGSTEMLHIYCSNTERALRPGSSGRAVPGYQIKLVDPDGGNVEGAGSGE
                     MFVRGGSMLAQYWHRADQTRSVLKGSWYRTGDRCRRDEDGFYWYEGRADDMMKVS"
     CDS_motif       complement(8018..8068)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03935.1_0001"
                     /evalue="5.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="QIC03935.1"
                     /protein_end="183"
                     /protein_start="166"
                     /score="19.1"
                     /tool="antismash"
                     /translation="LWLYSSGSTGRPKGVVH"
     CDS             complement(8678..10072)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 420.1;
                     E-value: 2.7e-127)"
                     /gene_kind="biosynthetic-additional"
                     /note="FAD-dependent oxygenase"
                     /product="EncM"
                     /protein_id="QIC03936.1"
                     /transl_table=11
                     /translation="MQFPQLDPAALAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRP
                     ALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSR
                     RLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDN
                     LTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFGLHRVGPVRFASTYYS
                     LDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHE
                     GERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTV
                     LEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTA
                     WAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQN
                     IPPSSP"
     CDS             complement(10130..11152)
                     /NRPS_PKS="Domain: PKS_AT (18-299). E-value: 2.4e-61.
                     Score: 199.5. Matches aSDomain:
                     nrpspksdomains_QIC03937.1_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 228; E-value: 4.1e-69)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl transferase"
                     /product="EncL"
                     /protein_id="QIC03937.1"
                     /sec_met_domain="PKS_AT (E-value: 8.6e-62, bitscore: 199.5,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAPTPHPRPPRPKVVLTFPGQGAQHARMAAGLYGVSKSFTSTMD
                     HAFDAFGPAGRTLREGWLAATPPAAFDDISYAQPLLYAVNCAMGAMVTEAGLRPDVLLG
                     HSVGELAAATLAGVFSFDCGLRYLSEYIGVYRHAPRGGMLAVAASPREVEAHLVPGVVI
                     GAVNAPRQVLLSAPEEALADVEAALRGAGITCSRARALQPFHHPVMRDVITAHAGLLTR
                     PPLHPPHTTLYSAYTGQELANELATDWQFWTGQPAEPVLFGPTLEHLLSSGPHLLVEAG
                     PGQSLTALARRTPAVARGDAKALALLPARAGEPDADIEAVRAALKQLATCGCDPLSPDF
                     "
     aSDomain        complement(10256..11098)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03937.1_PKS_AT.1"
                     /evalue="2.40E-61"
                     /label="QIC03937.1_PKS_AT.1"
                     /locus_tag="QIC03937.1"
                     /protein_end="299"
                     /protein_start="18"
                     /score="199.5"
                     /tool="antismash"
                     /translation="FPGQGAQHARMAAGLYGVSKSFTSTMDHAFDAFGPAGRTLREGWL
                     AATPPAAFDDISYAQPLLYAVNCAMGAMVTEAGLRPDVLLGHSVGELAAATLAGVFSFD
                     CGLRYLSEYIGVYRHAPRGGMLAVAASPREVEAHLVPGVVIGAVNAPRQVLLSAPEEAL
                     ADVEAALRGAGITCSRARALQPFHHPVMRDVITAHAGLLTRPPLHPPHTTLYSAYTGQE
                     LANELATDWQFWTGQPAEPVLFGPTLEHLLSSGPHLLVEAGPGQSLTALARRTPAVARG
                     "
     CDS_motif       complement(10775..10867)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03937.1_0002"
                     /evalue="1.30E-16"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="QIC03937.1"
                     /protein_end="126"
                     /protein_start="95"
                     /score="52.6"
                     /tool="antismash"
                     /translation="GLRPDVLLGHSVGELAAATLAGVFSFDCGLR"
     CDS_motif       complement(11051..11107)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03937.1_0001"
                     /evalue="1.70E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="QIC03937.1"
                     /protein_end="34"
                     /protein_start="15"
                     /score="17.3"
                     /tool="antismash"
                     /translation="VLTFPGQGAQHARMAAGLY"
     CDS             complement(11206..11454)
                     /NRPS_PKS="Domain: ACP (9-76). E-value: 3.9e-14. Score:
                     44.6. Matches aSDomain: nrpspksdomains_QIC03938.1_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 86.8; E-value:
                     1.3e-26)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl carrier protein"
                     /product="EncC"
                     /protein_id="QIC03938.1"
                     /sec_met_domain="PP-binding (E-value: 5.5e-11, bitscore:
                     33.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSSDQLLQILSECSGDEQALAQGDDILDREFEVLGYDSLVLLET
                     SAQLKHRYDIDIPEDVIRDLKTPRAVLEYVNVPASRN"
     aSDomain        complement(11227..11427)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03938.1_ACP.1"
                     /evalue="3.90E-14"
                     /label="QIC03938.1_ACP.1"
                     /locus_tag="QIC03938.1"
                     /protein_end="76"
                     /protein_start="9"
                     /score="44.6"
                     /tool="antismash"
                     /translation="ILSECSGDEQALAQGDDILDREFEVLGYDSLVLLETSAQLKHRYD
                     IDIPEDVIRDLKTPRAVLEYVN"
     CDS             complement(11502..12725)
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (7-406). E-value:
                     9.9e-30. Score: 95.6. Matches aSDomain:
                     nrpspksdomains_QIC03939.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 629.9; E-value:
                     2.4e-191)"
                     /gene_kind="biosynthetic"
                     /note="keto synthase beta"
                     /product="EncB"
                     /protein_id="QIC03939.1"
                     /sec_met_domain="t2clf (E-value: 2.2e-205, bitscore: 672.3,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDAVITGMGVTAPTGLSVKEYWNATLAGTQGIAPLQEFDPTPY
                     TARLAGQITGFEAKRHLPGRLLPQTDRVTRLALVAADRALEDAQVDVGELGTYECGVVT
                     SNATGGFEFSHREMQRLWTQGPDRVSVYQCFAWFYAVNTGQISIRHKMRGPGGVVVAEQ
                     AGGLDAIGHARRTITRGRSRLMVTGGVESSFDPWGWVSHLASGTVSTATDPATAYLPFD
                     QRACGYVPGEGGALLVMEDAQSARGRIDRRPYGKITGYAATFDPAPGAQRPSGLRRAVD
                     LALADAGLKPDAIDLVVADAAGVADLDAQEADALRAVFGPYGVPVCAPKTMVGRLMAGG
                     GPLDVVCALLALRDNVIPPAVNVTDVVDDYQIDLVRDEPRTCSLSRALVLARGAGGFNS
                     AVIVEHTP"
     aSDomain        complement(11508..12704)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03939.1_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="9.90E-30"
                     /label="QIC03939.1_PKS_KS.1"
                     /locus_tag="QIC03939.1"
                     /protein_end="406"
                     /protein_start="7"
                     /score="95.6"
                     /tool="antismash"
                     /translation="TGMGVTAPTGLSVKEYWNATLAGTQGIAPLQEFDPTPYTARLAGQ
                     ITGFEAKRHLPGRLLPQTDRVTRLALVAADRALEDAQVDVGELGTYECGVVTSNATGGF
                     EFSHREMQRLWTQGPDRVSVYQCFAWFYAVNTGQISIRHKMRGPGGVVVAEQAGGLDAI
                     GHARRTITRGRSRLMVTGGVESSFDPWGWVSHLASGTVSTATDPATAYLPFDQRACGYV
                     PGEGGALLVMEDAQSARGRIDRRPYGKITGYAATFDPAPGAQRPSGLRRAVDLALADAG
                     LKPDAIDLVVADAAGVADLDAQEADALRAVFGPYGVPVCAPKTMVGRLMAGGGPLDVVC
                     ALLALRDNVIPPAVNVTDVVDDYQIDLVRDEPRTCSLSRALVLARGAGGFNSAVIVEHT
                     "
     CDS_motif       complement(12027..12065)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03939.1_0001"
                     /evalue="2.00E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="QIC03939.1"
                     /protein_end="233"
                     /protein_start="220"
                     /score="11.4"
                     /tool="antismash"
                     /translation="FDQRACGYVPGEG"
     CDS             complement(12722..14044)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (21-410). E-value:
                     1e-51. Score: 168.0. Matches aSDomain:
                     nrpspksdomains_QIC03940.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 455; E-value:
                     4.2e-138)"
                     /gene_kind="biosynthetic"
                     /note="keto synthase alpha"
                     /product="EncA"
                     /protein_id="QIC03940.1"
                     /sec_met_domain="t2ks (E-value: 3e-230, bitscore: 754.7,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGGGLPLEQHPARSQGVSRHVVITGLSVLAPGSTDTEGFWKMIT
                     AGRSAIRRITAFDPTPFRSQVAGEVDLDPLACGFSRREVRRLDRASLLAVACARRAVAE
                     AGITSGTSVDPGRIGVSVGNAVGSATSIENEYVVLSDEGRQWLVDQKYQSPHLFDYFVP
                     GSLARETAWAAGAEGPVSVISAGCTSGIDALGHACQLIQEGSADVMVAGATDAPVTPIA
                     VACFDAIKATTRRNDDPEHAPRPFDRTRDGFAIAEGAAMLVLEDSEHARRRGADIYGTI
                     TGYAAHSNAYHMTGLSRDGNEMARAITTALDEARTDPTAVGYINAHGSGTKQNDLHETE
                     AFKKALGEHAYNVPVSSVKSMIGHSLGAIGAIEVATCALAIRNGVVPPTANLHEPDPDC
                     DLDYVPLEARDVDLDVVLTVGSGFGGFQSAMVVEKWRGGHV"
     aSDomain        complement(12815..13981)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03940.1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.00E-51"
                     /label="QIC03940.1_PKS_KS.1"
                     /locus_tag="QIC03940.1"
                     /protein_end="410"
                     /protein_start="21"
                     /score="168.0"
                     /tool="antismash"
                     /translation="VVITGLSVLAPGSTDTEGFWKMITAGRSAIRRITAFDPTPFRSQV
                     AGEVDLDPLACGFSRREVRRLDRASLLAVACARRAVAEAGITSGTSVDPGRIGVSVGNA
                     VGSATSIENEYVVLSDEGRQWLVDQKYQSPHLFDYFVPGSLARETAWAAGAEGPVSVIS
                     AGCTSGIDALGHACQLIQEGSADVMVAGATDAPVTPIAVACFDAIKATTRRNDDPEHAP
                     RPFDRTRDGFAIAEGAAMLVLEDSEHARRRGADIYGTITGYAAHSNAYHMTGLSRDGNE
                     MARAITTALDEARTDPTAVGYINAHGSGTKQNDLHETEAFKKALGEHAYNVPVSSVKSM
                     IGHSLGAIGAIEVATCALAIRNGVVPPTANLHEPDPDCDLDYVPLEARD"
     CDS             14182..14982
                     /NRPS_PKS="Domain: PKS_KR (9-182). E-value: 3.1e-12. Score:
                     38.6. Matches aSDomain: nrpspksdomains_QIC03941.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     242.9; E-value: 5.7e-74)"
                     /gene_kind="biosynthetic-additional"
                     /note="ketoreductase"
                     /product="EncD"
                     /protein_id="QIC03941.1"
                     /sec_met_domain="adh_short (E-value: 3.5e-37, bitscore:
                     118.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAHTESPSVALVTGGTSGIGLSIAQALLQDGLKVIITGRDPGKL
                     ETVVRSLKMEDDQFDVAGYTCDVRDRDAVHDMVERCAKEHGEPKVLVNNAGRSGGGVTA
                     AIPDELWLDVINTNLNSVFWVTREVIRSSDAIKQPAGRIINIASTGGKQGVPYGAPYSA
                     AKAGVIGFTKALAKEFAAHGGPTVNAVCPGYVETPMAQDIRASYAKLNNVTEEQVLADF
                     EAKIPLGRYCTPEEVAGMVRYLVSPAAASVTAQALNVCGGLGSY"
     aSDomain        14209..14727
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03941.1_PKS_KR.1"
                     /evalue="3.10E-12"
                     /label="QIC03941.1_PKS_KR.1"
                     /locus_tag="QIC03941.1"
                     /protein_end="182"
                     /protein_start="9"
                     /score="38.6"
                     /tool="antismash"
                     /translation="VALVTGGTSGIGLSIAQALLQDGLKVIITGRDPGKLETVVRSLKM
                     EDDQFDVAGYTCDVRDRDAVHDMVERCAKEHGEPKVLVNNAGRSGGGVTAAIPDELWLD
                     VINTNLNSVFWVTREVIRSSDAIKQPAGRIINIASTGGKQGVPYGAPYSAAKAGVIGFT
                     KALAKEFAAH"
     CDS_motif       14215..14301
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03941.1_0001"
                     /evalue="2.40E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="QIC03941.1"
                     /protein_end="40"
                     /protein_start="11"
                     /score="23.4"
                     /tool="antismash"
                     /translation="LVTGGTSGIGLSIAQALLQDGLKVIITGR"
     CDS             15010..15735
                     /codon_start=1
                     /note="O-methyl transferase"
                     /product="EncK"
                     /protein_id="QIC03942.1"
                     /transl_table=11
                     /translation="MTIDASPESSAFGFEGQSYYEHRRLRLYDAVVVHASNRLLWRCPK
                     SRLLEHYNDWITSRHLEVGPGSGYYLDHCHFPAGTPELTLLDLNPDPLKFAAHRLRRYT
                     PRCVQSDILEPLPDFVGSGFTSIAYNYVMHCLPEPPGGKHIVFKHLREALAPDGVLFGS
                     TVLSQGVKHTALSRRFNILYQRQGSFHNQHDSVHGLHQALEEHFASHWIEVRGSVALFA
                     ARASHTTAPRRPGASLDQR"
     CDS             15732..16952
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124:acetyl-CoA acetyltransferase (Score: 281.4;
                     E-value: 1.6e-85)"
                     /gene_kind="biosynthetic-additional"
                     /note="beta-oxoacyl-CoA thiolase"
                     /product="EncJ"
                     /protein_id="QIC03943.1"
                     /transl_table=11
                     /translation="MSEEKRMTSGATYRDAAIPLTALWTSPFARWGGALSHLSSLDLAV
                     AATGRALSERGIDRDTIEGMVLGWTVPQPAIFYGATTLAARLGMPQVSGPMLNQACATS
                     VAALHQAAAAVGTGVGPQLIVTTDRTSNGPDLSWPSPAGSGQGPVRENWVRDSFSRDPV
                     TGQSMLATAEAVAAECGFTRDDLDALAVLRSEQYTAALSNDRTFQRDFMVGIEIEQDGL
                     GTVRLLSDEGVRPVTADSAGQLPTVRPGGVHTAATQTHPADGTAGALVTTTPCAREFAD
                     RGPIVRLVASGFARVEPARMPRALVPAAQAALHAAGLKIDTMDAISTHNPFAVNDLYFA
                     RETGVTLEAMNASGCSLLFGHPQGPTGLRMVTELAHVLKARGGGLGLFTGCAAGDTAAA
                     LIIEVTD"
     CDS             complement(17098..17874)
                     /NRPS_PKS="Domain: ECH (15-239). E-value: 8.9e-45. Score:
                     144.7. Matches aSDomain: nrpspksdomains_QIC03944.1_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 181.6; E-value:
                     2.5e-55)"
                     /gene_kind="biosynthetic-additional"
                     /note="enoyl-CoA hydratase"
                     /product="EncI"
                     /protein_id="QIC03944.1"
                     /transl_table=11
                     /translation="MSDVQQLLSSADLTVTVDSDVAVIAMSRPAKLNALTRGMRRDLAE
                     LLRHYGDGSQARGVVITGQAKAFSAGMDLREVAGPEVDLLAEMELFNDITRAALITEVP
                     VVAALNGIAVGGAGEMALSFDARIATAQAAISWPETSVGLTVSNAASLFLPRLAGAPRA
                     LHLIMNSARLSASQALAFGLLDDIVEPEDLIPAAIRLIHQWTPPGSSTAAHLRLMRPSL
                     RAVEAAMAREGAAVRQVQESGIAQAGIATVLAGHGK"
     aSDomain        complement(17158..17829)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03944.1_ECH.1"
                     /evalue="8.90E-45"
                     /label="QIC03944.1_ECH.1"
                     /locus_tag="QIC03944.1"
                     /protein_end="239"
                     /protein_start="15"
                     /score="144.7"
                     /tool="antismash"
                     /translation="TVDSDVAVIAMSRPAKLNALTRGMRRDLAELLRHYGDGSQARGVV
                     ITGQAKAFSAGMDLREVAGPEVDLLAEMELFNDITRAALITEVPVVAALNGIAVGGAGE
                     MALSFDARIATAQAAISWPETSVGLTVSNAASLFLPRLAGAPRALHLIMNSARLSASQA
                     LAFGLLDDIVEPEDLIPAAIRLIHQWTPPGSSTAAHLRLMRPSLRAVEAAMAREGAAVR
                     QV"
     CDS             complement(17871..19478)
                     /NRPS_PKS="Domain: AMP-binding (35-422). E-value: 3.1e-86.
                     Score: 281.4. Matches aSDomain:
                     nrpspksdomains_QIC03945.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     373.5; E-value: 2.2e-113)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA ligase"
                     /product="EncH"
                     /protein_id="QIC03945.1"
                     /sec_met_domain="AMP-binding (E-value: 2.9e-94, bitscore:
                     306.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPAPQAPTQPVIDARHPEAGPRWETIGELIKDAALLHGDKEFLR
                     CGDKTLSFSETDTRTDRLAQALIAQGVKPGDRVAVMMDNVADWPLSWFAAIKAGAITVP
                     VNTRFGATDLAHVLRDSQAVLVLASPGCVPLARDVSGSIGHPCAVRTLRELKAGFGDRP
                     VDGPGLSAHADDTVNFQYTSGTTGFPKACMLSHDYWLRTAWVIAVHSGLRPDDVVLTAQ
                     AFSYMDPQWKAVMCLMGGVPLVVLPRFSASGFWHSVRQHRATLTYVLGSMPMLLYKQPP
                     HSGDRDHAMRLVLCSGIPRDLHHAFEDRWGAAWREVYGSTESGLDLIMPPGEEATVGSG
                     AMGYPPSGKEVLVADERQRPVQPGQIGEILVRGRPMMNGYWNNPDSTERAFRGGWYHTG
                     DLGRAEAAGSVVHAGRLKDMIRRGGENIAAAEVESVLEAHPAVLAAALAGIPDELFGEL
                     PKAFLQLRPGYRPTTATARSVLAHARRHLAKFKVPAYVEFVDSFPMTPSARIQKRQLLR
                     PGDDQRTGAFDAAADAWA"
     aSDomain        complement(18213..19373)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QIC03945.1_AMP-binding.1"
                     /evalue="3.10E-86"
                     /label="QIC03945.1_AMP-binding.1"
                     /locus_tag="QIC03945.1"
                     /protein_end="422"
                     /protein_start="35"
                     /score="281.4"
                     /tool="antismash"
                     /translation="LLHGDKEFLRCGDKTLSFSETDTRTDRLAQALIAQGVKPGDRVAV
                     MMDNVADWPLSWFAAIKAGAITVPVNTRFGATDLAHVLRDSQAVLVLASPGCVPLARDV
                     SGSIGHPCAVRTLRELKAGFGDRPVDGPGLSAHADDTVNFQYTSGTTGFPKACMLSHDY
                     WLRTAWVIAVHSGLRPDDVVLTAQAFSYMDPQWKAVMCLMGGVPLVVLPRFSASGFWHS
                     VRQHRATLTYVLGSMPMLLYKQPPHSGDRDHAMRLVLCSGIPRDLHHAFEDRWGAAWRE
                     VYGSTESGLDLIMPPGEEATVGSGAMGYPPSGKEVLVADERQRPVQPGQIGEILVRGRP
                     MMNGYWNNPDSTERAFRGGWYHTGDLGRAEAAGSVVHAGRLKDMIRR"
     CDS_motif       complement(18306..18392)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03945.1_0002"
                     /evalue="1.40E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="QIC03945.1"
                     /protein_end="391"
                     /protein_start="362"
                     /score="23.8"
                     /tool="antismash"
                     /translation="PGQIGEILVRGRPMMNGYWNNPDSTERAF"
     CDS_motif       complement(18891..18938)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QIC03945.1_0001"
                     /evalue="6.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="QIC03945.1"
                     /protein_end="196"
                     /protein_start="180"
                     /score="18.7"
                     /tool="antismash"
                     /translation="YTSGTTGFPKACMLSH"
     CDS             19645..20145
                     /codon_start=1
                     /note="hydroxylacyl-CoA dehydrogenase"
                     /product="EncG"
                     /protein_id="QIC03946.1"
                     /transl_table=11
                     /translation="MTTAGADPTQAEESALTQAPHKPEETAVSAALFAEIQQFYGRHMR
                     AMDEGRVEDWTGDFMPDAVFATNARPEPQRGRAEIARNAEAAARQLQEKGILRRHCVTT
                     LELQQASGLTLLAKTYALITKTVVGGRSELEFVCTCEDVLVRNEGRWFIRHRQVFRDDL
                     PKR"
     CDS             complement(20217..21068)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     301.5; E-value: 2.6e-91)"
                     /gene_kind="regulatory"
                     /note="transcriptional regulator"
                     /product="EncF"
                     /protein_id="QIC03947.1"
                     /transl_table=11
                     /translation="MDVEVLGHVTLKVGDERRTPSAPKARQVLALLLVNANRMVSTDVL
                     IEELWAEQPPRSALSALQTYVFQLRQLLRKIRPGECPKQLLVTTPNGYEFRVPPENVDL
                     QRYERHRLAGQQAFQAGENMAAVEQFRAALHIFAAPPLANVRRGMHLEAEIVRLEESRI
                     GVQETRIEAELELGRHHEVLSELSGLASQCPQHEGFHRQLMLALYRCGRRPQALKVFNQ
                     LRQSLVTELGLEPSRELQMLQQAVLSADPRLDTAERTPFLRTTADPAPLQVPWPTASPW
                     KV"
     CDS             complement(21826..22278)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1171:transcriptional regulator, MerR family (Score:
                     76.2; E-value: 7e-23)"
                     /gene_kind="regulatory"
                     /note="regulatory protein"
                     /product="EncE"
                     /protein_id="QIC03948.1"
                     /transl_table=11
                     /translation="MNAPLVPFVQVLRGWDVLAYEEVGLIVPSARSKGGFRLYTQADVS
                     RLMVIRHFKPLAFPLEEMRDLLEITDRLGAQDDPPAPVERERLRERLDAYRKVADARCE
                     TLRARLAMAEDFAATLRDRMNADARARSAGERATSGGPSAEALAHE"
ORIGIN
        1 gggggtgtcc atgccggtcc actacgggtg tggaagtgca ggtcagggcc ttctgatcca
       61 gcagacttca tccagttggt gatcgctgcg tgacagacga gtgatacggc gaggtcccgc
      121 agggcgcgtc cgggccggac tttgcgtggc gtcgcgcgtt gacgaagccg cgacggagca
      181 ttccgtcgcg gcttcgtcgt gagaccctgt cggctgccgc gcacgaagag gttggcactc
      241 cctgctgtcg gagccttatg acgcttcgcg ggtgcgccca cttcgcgatc gcactcattg
      301 ccgggagcgg atttcatgca tcccggaatg cgcgcacaca tgcaggtgcc ctccgcattg
      361 aggccgtgag cgtcaggcgt ggcgcaggca gagggagccc cactgtctgt acggcaccgt
      421 gctcacctcc ggcgccgcga gcctggtcgg cctcacctat gccaagctca ccgcccacct
      481 tggctatgcc gcgttgatgc ggatcgcggc cggagcgtgg acggcggcgc tgctggtctt
      541 tgccgtcgcc gggcagtggg ccgtgctgct gatcgtgccg gtgctcaccg ggatcggcag
      601 cggcatcacg atgcccaccc tgaccgtcct ggtcgaccgc ccgcccccgc cgaacagcgc
      661 ggcaccgcca cctcgctgca ggcgaccgcg ctcttcggcg gccagttcgc ctcgcctctg
      721 ctctccgggc cgctgatcga ctcgacctcg atcgccacgg gtgcactgtt cgccgccagc
      781 ggcaccgcgg gcatcctcgc cgcgctgttc cggctgaggg aaccggacca gtcggccgac
      841 atcgcaggcc ggaacgagaa gacccgcgcc ggactcccgt cggtgaatga tcacagcgtg
      901 acacctgacg agggcagccc agcacctcct taccggaggc cggcacggaa actcaccgcc
      961 gcatcgcgac ggactcgtcc cggccctctt gtggcgcagg cagcgccaag gccatcaccg
     1021 caacgcccgc gcacacagcc gccgtcgcca cgaacaccgc cctgtacgac aggtccggac
     1081 cgccgtcggc ggtagcgagg gtgacgaggg cagcgagccc gacgacaccg ccgagctggc
     1141 gggtggtgtt catcagcccg gaggctgccc ccgcatcctg ctcgcggatg ccggaggtga
     1201 cggtggtagt gatcggggtg atgagcagtc ccatgccggc ggacatgacg atcgcgggcc
     1261 cgagcagtcc gtccaggtag ccgctgtccg tgctgatgct gctctgccag aggaagccga
     1321 cggcgctgag gacggcgctg agaacgatga ggccgcgggc gccggtgcgc tccatgacgg
     1381 ccggggcgag gcgggcagcc gcgataccga caagcgtgtg gggcaggaaa ccgacgcccg
     1441 tggccaaggc cccgtagtgg aggacctcct gcatgtacag cgacaggaag taccacatag
     1501 ggatgaagca gccgcccgcc agcagcatgg tgacgttgcc ggcccagatc gggcgcagcc
     1561 gcaccaggcg gggcggcatc aggggggccg ccgtgtaccg gctctccgtc accgcgaacg
     1621 cggtcagcgc cacggcgctg accgccaggc ccgtcagggt ggtcgcccct gtccagccct
     1681 gtgttccggc ctggttgacg ccgtagacga gtgcggtgac gccgagggtg gccagcaccg
     1741 ccccggggac gtcgagcctg ccggataccg cgcgggagcg gtcggacggc agcagacgca
     1801 gggccgccag gacggccacg gtgccgatcg gcacgttgat cagcaggatc caccgccagg
     1861 acagtgcgtc ggtcaggacg ccgccgatca ggttgcccgc cgcgcctccg gcggagctga
     1921 ctgcagtcca gatcgccaac gctggtgcgg cccggccctt cggggaaggt ggtggtcagg
     1981 atggtcagcg tggccggggc cagcaccgcg gcgcccaggc cctgcaccgc ccgcatggcg
     2041 atcagcaggc cggggccggt ggcgagtccg cccaccaggc tggagacgga gaacagcgcc
     2101 agcccccaca cgaacgcccg acgtcggccg tacaggtccg cgagccgacc gccgagaagc
     2161 aggaaacccg cgaagaccag cgcgtagctg cccacgaccc actgcagtcc cgccgcgtcg
     2221 aagccgagcg cggtctggat cgacggcagc gcgacgttca ccaccgacac gtcgagcacc
     2281 accatgaact gtgccgcgca ggccagccac aacagcgccg cctgacgggg caccagtgcg
     2341 cctgtctctt tctcggtgtc gactgatccg tcggcggcac gggcttcgcg ttgtcccatg
     2401 tctcttcccc atcgtcgcgg ccagctttta tagtacagcg gtactatgaa aaagggtcga
     2461 acgggaaggg gtcacggtgc cgaaacgtgt tgaccatgcc cagcgccggg cgcacattgc
     2521 tgacgccctg gtccgggtgg ccgcgcggga cggactgcat gcggtgacca tgcgcgcggt
     2581 cgctgccgag gcgggcatgt ccttgaacct ggtgcagtac tacttcgaca ccaaggccca
     2641 gttgatgcac gccgctctgc agcaccttga gcagcagagc catgagcggt ggtcggcgcg
     2701 gctggagagc ctggaggatc cggggtcggc acgggcctgt ctggaagcgt tcgtggatga
     2761 agccctgccg gtcgacgcgg acagccacac cttccggctg gtgtggacgt cctacgcggt
     2821 actggccatg accgaccccg agctggcgga gcagcccttc gtcgaggggc cgaaccggct
     2881 tgagcgacag ctcacccaca tcctggccac ggcgcaggcg gcgggagaga tcgcggctta
     2941 tctggatgtc tccgccgagg ccgcgcgtct gctgagcctc agtcacggtg tcgggaccag
     3001 cgtgctggtc gggcagcggt cggcggcaca agcccggtac gtgatgctct accacctctc
     3061 ccgcttgttc aacgacccca ctccacccga ggcccctggc cagcacttag cggcagcttc
     3121 ctgactggtg ccggctcgga aacgggacgc cccgccgtgc gatgtgcggc agggctcgcg
     3181 agtggactgc cccgcttgac ggacaggaga agctcagtga ccacccatac ccagcagttg
     3241 tgggactttc ccttcgcgcc ccccgccgag ctgcacatgg aaccggcctt cgcgcaattg
     3301 cgcgaagagg agcccatcag tcgcgtccgc ctcccgtacg ggggtgaggc atggctggtc
     3361 acgcgttatc aggacatcaa gaccgtgctg ggcgacccgc ggtttagtcg tgccgccacg
     3421 cagcacgccc aggcgccgcg gatccagcct gacccggcgg gtgaaggcgt gctgatgtcg
     3481 ctggatcccc cggaccacac gcggctgcgt aaaacggtcg cgggtgtctt caccaagcgc
     3541 agggtggaag atctgcggcc cgccacgcag aggatcgccg aggagttgct ggaggcgatg
     3601 gaagcctcgg gcgcaccggc cgatctggtc gcatcctatg cactgccgct gcccgtcacg
     3661 gtgatctgcg acctgctggg tgtacccggg gacgaccgtg aacagttgcg gggctggtcc
     3721 gatgcgctgc tgtccaccac ggcctgcact ccagctgaat cggcggcggc cgcgcaggcc
     3781 atggccgacc acttcgccgc cctggtgagc cagcggcgct gccagccgac cgatgacctg
     3841 ctcggggctc tggtgcagac gtgggaccgg gaggaggggc tgcttcgcga cgaggagctg
     3901 gtccttctca cccgtgatct gctcatcgcc ggccatgaga ccacggcgag ccagatcgcc
     3961 aactgcacct acctgctgct ccagcgcccg catgacatgg accgcttgcg cacggatccc
     4021 gcggcgatgg cgtccgcagt ggaggagctg ctgcggttca tcccgctggg ctcgggcagt
     4081 ttccgggcca gggtcgccac cgagccggtg gaactgtgcg gggtgaggat ccagcccggt
     4141 gacaccgtgt tcgcccccac tgtggcggcc aactgggatc cggacgtctt tgctgagccg
     4201 ggccgcctcg atatcgacag gtcccccaac ccgcacgtcg ccttcgggca cggtgtgcac
     4261 cactgcctgg gtgcgcagtt ggccaggctg gagctccagg tggcgctggg cgtcctgttg
     4321 cgccgtctgc cgcggctgcg actggctgtc gacgaagcgg agatcgtgtg gaagacgggc
     4381 atgcaggtac gtgggccgaa gaccctgccg gtgaagtggt gaccggggag tctgcggctg
     4441 caggccgctg gcggctggcg gtggacgcga cgttgtgcat cggatcgggt gcgtgtgccg
     4501 gttcctctgc ccatttccgg atgacgcagg acggccacgc cgagccgcgc gaggacgtca
     4561 tcgtcgccga tgacacggca cgggacgccg cggagtgttg cccagtggag gccatcacgg
     4621 tgtccgacac cagtaccggc gagttgatcg caccgacgtg agccgcgggg catgtcacca
     4681 cttcagcatc acatcccctg tggccatgga ggaaccgcct gtcgactacg ggccgcctcg
     4741 cgggggagcg ccgaggggct cagggggtga ccttgggcgg gccatgaggc tgccttgctt
     4801 gggcgtggag tgacgggcgc ttcagtgaat tcggtgcgtc actcagccga cctgcccggt
     4861 cgcgatccgg atggccgtcg gcgtgccgcg cctgtccgct ggcatgggca gacggtctgt
     4921 acaacccgtc gagtccaccg attctccggc cgcaaaggga acttcatgac cctcgtcata
     4981 gacctcgaca tgaacgtcac gctcgaccaa cttgaggacg cggcgcgaca gcgcacgccc
     5041 gtggagctgt ccgcacccgt ccgctcccgc gtccgcgcct cgcgcgacgt attggagaag
     5101 ttcgtgcagg acgaacgtgt catctacggg gtcaacacca gcatgggggg cttcgtcgac
     5161 cacctcgtcc cggtgtccca ggcccggcag ctccaggaga acctgatcaa cgcggtcgcc
     5221 accaacgtgg gggcgtatct ggacgacacg accgcccgga ccatcatgct gtcccgcatc
     5281 gtgtcgctgg cgcgcgggaa ctccgcgatc accccggcga atctggacaa gctggtggcc
     5341 gtactcaacg ccgggatcgt gccgtgcatc ccggagaagg gctctttggg caccagcggt
     5401 gacctcggcc cgctggccgc gatcgccctg gtgtgcgcgg ggcagtggaa ggcccgctac
     5461 aacggtcaga tcatgcccgg gcggcaggcc ctgtccgagg ctggcgtcga gccgatggag
     5521 ctgagctaca aggatggcct ggccctgatc aacggcacgt cgggcatggt cggcctgggc
     5581 accatggccc tccaggccgc gcgccggctc gtggaccgct acctgcaggt gtccgcgttg
     5641 tcggtcgagg gcctggcagg catgacgaaa ccgttcgacc ctcgcgtgca cggcgtcaag
     5701 ccgcaccgcg ggcagcgtca ggtggcctcg cggttgtggg aggggcttgc cgactcgcac
     5761 ctggcggtca acgaactgga cactgagcag accctggccg gagagatggg cacggtcgcc
     5821 aaggccggtt cgctggcgat cgaggacgcc tactccatcc ggtgcacgcc gcagatcctc
     5881 ggtcccgtgg tcgatgtgct ggaccggatc ggggcgaccc tgcaggacga gctgaactcc
     5941 tccaacgaca acccgatcgt cctgccggag gaggcggagc tgttccacaa cgggcacttc
     6001 cacggccagt acgtggccat ggccatggac cacctgaaca tggccctggc caccgtgacc
     6061 aatctcgcca accggcgcgt ggaccgcttc ctggacaaga gcaacagcaa cgggctgccc
     6121 gccttcctgt gccgggaaga tccgggactg cgcctgggcc tgatgggcgg ccagttcatg
     6181 accgcgtcga tcaccgcgga gacccgcacc ctgaccattc cgatgtcggt gcagtccctc
     6241 acgagtacgg cggacttcca ggacatcgtg tccttcggat tcgtcgccgc ccgccgcgcc
     6301 cgggaggtac tcaccaacgc cgcctacgtg gtggccttcg agctgctgtg cgcctgccag
     6361 gccgccgaca tccgcggcgc ggacaaactg tcctctttca cccgcccgct ctatgagcgc
     6421 acccgcacga tcgtgccgtt cctcgaccgg gacgagacca tcaccgacta cgtcgagaag
     6481 ctggcggccg acctgatcgc gggcgagcct gtcgacgctg ccgtggcggc gcactgaagc
     6541 cgcacctgga agggagacac accatgacga ccacactggc cgagcaggcg gttacggact
     6601 tcgtccggga atggagcacg gccgaagagc ggggagagca cagggcgctg gacgacctgc
     6661 tcgcgaagga cttcgtcggc gtcgggcccc agggcttcgt gcgcagccgc gaggagtggc
     6721 tggcccgcta cagcacgggc accgtgcgca acacgtcgtt tgaggtgagc gacctgcgta
     6781 tccgctccta cggggagacg gcggtcgtgg tggcggccca gacccagcag agtgtgaacg
     6841 gtgatgccga cgccagtggt gcattccgct tcacgctcat cgtcgtccgc caggacgggc
     6901 ggctgcggct cgccggcctg cacctgagcc cgaacgccgt cccggcaggc ggctgagccc
     6961 ctgccgggac ggcgtgggct ccggccgccc gcgctggtca cacggcgtgg gcggccggag
     7021 catccgcctt tcccgtctcc tgtgagcgca gggcgaaccg ctgaatcttg cccgtaggcg
     7081 tcttgggcag gtccgcggcg aactcgacca ggtgcggaaa ctgatgactg gccagacggt
     7141 ccttgcacca ctgccgcagc tgccgggcca gtgcgtcgct gccctggcag ccgtcgcgca
     7201 gcacgatgaa cgccttgatc cgggtgaggc ggtcggtgtc cacgccgacg accgctgcct
     7261 cggcaacatc cgggtgctgc tgaagggcgg tctcgatcgc ggcgggagcg acccacagcc
     7321 cggagacctt catcatgtcg tcggcacgtc cctcgtacca gtagaagccg tcctcgtcgc
     7381 ggcggcagcg gtcgccggtg cggtaccagc tccccttcaa caccgagcgg gtctggtcgg
     7441 cacggtgcca gtactgggcc agcatgctgc cgccccgcac gaacatctct ccgctgcccg
     7501 cgccttccac attgccgccg tcggggtcga cgagcttgat ctggtagccg ggcacggccc
     7561 tcccggagga gccggggcga agcgcccgct cggtgttgct gcagtagatg tgcagcattt
     7621 cggtggaccc cacaccgtcc aggatcgtca gcccgtaaag gtcgcgccat cgttcccaga
     7681 cgtgggcggg caggctctcg gcggccgaga cgcacagccg gatggacgtc aggtcccgag
     7741 agccagcgcc gggcgagcgg ggcatggcgt tgtacaaggc cgggacggag aacagcagcg
     7801 tgggacgtac tcgttcgatg gtctccagca cgaggtgcgg tgccggaaac ccgggcagca
     7861 ggacgcatgt cccgccgaac cacagcggaa acagcaggct gttgcccagg ccgtaggcgt
     7921 ggaagagctt ggtggtggac aggtgcacgt cgtcctgagt gacacccagg acatcgcccg
     7981 cgtagtgccg gcaggcgggt gcgatgtccc gctgcaggtg gaccacccct ttgggccgtc
     8041 cggtggaccc ggagctgtac agccacagcg cgggatcctc ggcgtgtgtg gacgcggcgc
     8101 ccagctcgcc ctcgtggccg cggatcaggt cgcgcatgtg gaacctgccg tcgtccggcc
     8161 ctgcgggctc ggtgctgatc accatcacgc cggcctcctg cagagcgggc gcgagctcct
     8221 cgtaccggtc cgcctcgatc acagccgccc gggcgtaact gtcctgggcg tagaaacgca
     8281 cctgttcagg gtcggtttgg tagttgatcg ggaccgggac ggcgccgatg cggccggcgc
     8341 cgaggaaggc ggtgaagaac gccggggtgt cgtccaggat gagcaggacg cgctgttcgc
     8401 gctggatgcc aagctcacgc agagcccggc ccatcgcaca catgctccgg tacagctcgc
     8461 cgtagctgac gtggccgtgg gggctgtaga gggcggcctt gtcgctcagg ccgctgtcga
     8521 gatggtggtc gaccagggtg gagaggttga agaggtcggt ggtcatgtcg gctcctgttc
     8581 gagaggcatg gagctgatcg gcccccgggt gtgaccctgc cccggtcgcg gcattggccg
     8641 ggagccgggg cagagctggg tgggggcgtg gtgtgggtca ggggctgctc gggggtatgt
     8701 tctggttgag gcggaacagg ttcgtcgggt cgtacttggc cttgacgccc tgcaaccgtt
     8761 cgaacttggc ggccccgtaa gcctcccgcg tgcggtccgc ctcgcccggg ttcatgaagt
     8821 tgacgtagcc gccggacaag tggccggcca gggcccggta gccctcgcgg gcccaggcgg
     8881 tgtggcgggc gtcctcggtg gggtccatcc aggcggcggc caggttggtc acgaacggcg
     8941 actggcggtt ggggtaggcg gtggcgtcgt cgggcacgcg cgccacggcc ccgcccaggt
     9001 agagcagttc gagctgggtg aacggggagg cgatgtcggc ggcgtgttcc aggaccgtgt
     9061 cggtggcttc atcgctcagt tcgttcagat agccgctctt ggtgtagatc cggtcgggga
     9121 cgacggcgcc gggaaaggag tacgcctgca gggcccggta gggcaaggtc gccttggtca
     9181 gaccgtgggg cttgccggcg tgaaggatgg actcaagctg ccgctcaccc tcgtgcgggt
     9241 ccccgatcca gcagctcatg gcgcagatca ccggcttgcc gtgcatgtcg gcgggcagtt
     9301 cgggcagcgg cggtgccagg cgcagataca acgcccaggt cagttcgtcg ggggcggtgg
     9361 ccatgtggtc gcgccaggcc cggatgacct ggggtccttc gtccagcgag tagtaggtgc
     9421 tggcgaaacg gacgggcccg acccggtgga ggccgaactc gaatgcggtc accacaccga
     9481 agttgccgcc gccgccgcgg acggcccaga acaggtcggg gttctcggtg tcgctcgcag
     9541 tgaggacgcc gccgtccgcg gtaacgatct ccacggaggt gaggttgtcg atggacaggc
     9601 cgtacttgcg gctcagccag ccgaatccgc cgccgaggac gagtcccccc aatccggtgt
     9661 gggagaccac gccggcgggg gtggcgagca tgtgggcctg tgtggcggtg tcgaacgccc
     9721 ccagcaggca gccgccctgg gctcgcgcgc gccgcaggcg gcggctgacc ttgatgctgt
     9781 tcatcaagga gagatcgatg acgatcccgc cgtcgcatac cgagtgcccg gccatgctgt
     9841 gtccgccgcc gcggaccgcg accagcaggc cgctcttgcg ggcgaagctc accgcggcga
     9901 ccacgtccgg ggtgctggtg cagcgggcga tcagcgcggg gcgccgatcg atcgtgccgt
     9961 tccagatgcg gcgcgcctcg tcgtagtcgg cgtcgctcgg ccagatcaac tccccccgga
    10021 acgccgcgct gaacgcggcc agggcggcag ggtcgagctg tgggaactgc atgctggtcc
    10081 ctttctgcgg cgccacgacg ggcgcttgac ggggctggcg gctggggggt cagaagtccg
    10141 gagacagcgg gtcgcatccg caggtggcga gctgcttcag ggcggcccgt acggcttcga
    10201 tatcggcgtc cggctcgccc gcgcgggccg gcagcagggc gagggccttc gcgtcaccgc
    10261 gggcaaccgc gggcgtgcgc cgtgccaggg cggtcaggct ctgtccgggg cctgcctcga
    10321 ccaagaggtg agggccactg ctcagcagat gctccagggt ggggccgaac aggaccggct
    10381 cggcgggctg accggtccag aactgccagt cggtggccag ctcgttggca agttcctgcc
    10441 cggtgtaggc ggagtagagg gtggtgtgag gcgggtggag gggcggacgg gtgagcaagc
    10501 ccgcgtgggc cgtgatgacg tcgcgcatca ccgggtggtg gaagggctgc agggcgcggg
    10561 cgcgggaaca ggtgataccg gcaccgcgga gggcggcttc cacgtcggcc agggcctctt
    10621 ccggggcgga gagcagaacc tggcgcggtg cgttgacggc gccgatgacc acgcccggca
    10681 ccaggtgggc ttcgacctcc ctgggactgg cggccacggc aagcatgccg ccgcgcgggg
    10741 cgtgccggta gacgccgatg tattcggaca ggtagcgcag gccgcagtcg aaggagaaca
    10801 cgccggccag ggtggcggcg gccagttccc ccacactgtg gcccagcagg acgtcggggc
    10861 gcagaccggc ctcggtgacc atggcgccca tcgcgcagtt gaccgcgtac agcaggggct
    10921 gggcgtagga gatgtcgtcg aaggccgcgg gtggtgtggc cgcgagccat ccttcgcgca
    10981 gtgtgcgtcc cgccggtccg aaggcatcga aggcgtggtc catcgtggag gtgaaggact
    11041 tggagacgcc gtagaggccg gcggccatgc gggcgtgctg tgccccttgg ccggggaagg
    11101 tgagaacgac tttggggcgc ggcggacggg ggtgtggggt gggggcgtcc atcagctggc
    11161 tcctgcggtg caaaaaaagg ggcgggaggc gggcggacgg gtgcctcagt tcctgctggc
    11221 ggggacgttg acgtactcca ggacggcgcg cggtgtcttc aggtcccgga tgacgtcctc
    11281 cgggatgtcg atgtcgtagc ggtgcttgag ctgggcggag gtctccagca ggaccaggga
    11341 gtcgtagccg aggacctcga actcgcggtc gaggatgtcg tcgccctggg cgagggcctg
    11401 ctcgtcgccg gagcactcgc tgaggatctg caggagctgg tcgctgctga gcatgcggaa
    11461 cggtcccttc tcaatgggtg ggaacacagg gagtggtggt ttcagggggt gtgctcgacg
    11521 atgacggccg agttgaagcc gccggcgccg cgcgcgagga cgagggccct cgacagggag
    11581 cacgtgcgtg gctcgtcacg gacgaggtcg atctggtagt cgtcgacgac gtcggtgacg
    11641 ttgacggccg gtgggatgac gttgtcgcgc agcgcgagca gggcgcacac cacatcgagt
    11701 ggccctccgc cggccatcag gcgaccgacc atggtcttgg gcgcacagac ggggacgccg
    11761 tacgggccga agacggcccg cagagcatcg gcttcctggg cgtcgaggtc ggcgacgcct
    11821 gccgcgtcgg cgacgacgag gtcgatggcg tcgggcttaa gccccgcatc cgccagagcc
    11881 aggtccacgg cgcgccgcag accggagggc cgctgcgctc cgggggcggg gtcgaaggtc
    11941 gccgcgtagc cggtgatctt tccgtaggga cgccggtcga tgcgtccgcg cgccgattgg
    12001 gcgtcctcca tgacgaggag ggcaccgcct tctcccggca catagccgca ggcccgctgg
    12061 tcgaacggca ggtaggcggt ggcggggtcg gtggccgtgc tgacggtgcc ggaggccagg
    12121 tgggacaccc agccccatgg gtcgaaggag gactcgacgc cgccggtgac catcaggcgg
    12181 ctgcggccgc gggtgatcgt gcggcgggcg tgcccgatcg catcgaggcc gcctgcctgt
    12241 tcggcgacga ccacgccgcc cgggccacgc atcttgtgcc ggatggagat ctggccggtg
    12301 ttgacggcgt agaaccaggc gaagcactgg tagacgctga cacgatcggg gccctgcgtc
    12361 cacagccgct gcatctcgcg gtgggagaac tcgaagccgc cggtcgcgtt cgaggtgacg
    12421 acaccgcact cgtaggtgcc gagttcgccg acgtcgacct gggcgtcctc cagcgcgcgg
    12481 tcggcggcga ccagggcgag ccgggtgacg cggtcggtct gcggcagcag ccgcccgggc
    12541 aggtgcctct tggcctcgaa gccggtgatc tgcccggcca gccgcgccgt gtacggcgtg
    12601 ggatcgaact cctgcagcgg ggcgatgccc tgggtgccgg ccagggtggc gttccagtac
    12661 tccttgacgc tcaggccggt aggcgcggtc acacccatcc cggtgatcac ggcatcggtg
    12721 ctcatacgtg gcctcctcgc cacttctcca cgaccatggc gctctggaac cccccgaacc
    12781 cgctgcccac ggtcaggacg acgtcaaggt ccacatcacg cgcctcaagg gggacgtagt
    12841 ccaggtcgca gtccgggtcg ggctcatgga ggttcgcggt ggggggcacc actccgttgc
    12901 ggatggccag cgcgcaggtt gcaacctcga tcgcgccgat cgcgcccagg gaatgcccga
    12961 tcatcgactt gacggagctg accgggacgt tgtaagcgtg ctcgcccagg gccttcttga
    13021 acgcctcggt ttcatgcagg tcgttctgtt tcgtgccaga gccgtgggcg ttgatgtacc
    13081 cgacggccgt ggggtcggtg cgggcctcgt ccagggcggt cgtgatggcg cgggccatct
    13141 cattgccgtc ccgggacagg cccgtcatgt ggtaagcgtt cgagtgcgcg gcgtaaccgg
    13201 tgatggtgcc gtaaatgtcg gctccgcgcc gccgggcgtg ttcgctgtcc tccaggacca
    13261 gcatggccgc cccctcggcg atggcgaatc cgtcccgggt gcggtcgaag ggccgcggcg
    13321 cgtgttcggg atcgtcgtta cggcgcgtgg tggccttgat cgcatcgaag caggccaccg
    13381 cgatcggggt gacgggagca tcggtggcgc cggcgaccat cacgtcggca ctgccctcct
    13441 ggatgagctg gcaggcatgg ccgagggcgt cgatgccaga ggtgcagccg gccgagatga
    13501 ccgacaccgg tccttcggca ccggccgccc aggcggtctc gcgggcgagg gaacccggga
    13561 cgaagtagtc gaacaggtgg ggggactggt acttctggtc gaccagccac tggcgtccct
    13621 cgtcggacag cacgacgtac tcgttctcga tacttgtggc ggatcccacc gcgttgccca
    13681 cgctcacacc gatgcggcca gggtcgacac tcgtaccgga ggtgatcccg gcttccgcca
    13741 ccgcccgtct ggcgcaggcc acggccagca ggctggcccg gtccagacgc cggacctcgc
    13801 ggcggctgaa cccacaggcc agcggatcga gatcgacctc tcccgccacc tgggaacgga
    13861 acggcgtggg gtcgaatgcc gtgatcctgc ggatcgcgct gcgccccgct gtgatcatct
    13921 tccagaagcc ctcggtatcc gtcgaaccgg gtgcgaggac gctcaggcca gttatgacta
    13981 cgtgtcggct cacaccttga gaccttgcgg ggtgctgctc cagcggcagt ccaccgccgc
    14041 tcatcctctg ctccagagcg ccttgcttgg gcggcagaga gcgccttgcc cgcgcgtgga
    14101 ccggccctgc accgccagca gggaccctcg tcgtcgggcc ggcccgttcc ggccgccccg
    14161 acgaagggag aaagtctcac catgcccgca cacaccgagt ccccaagcgt cgctctggtc
    14221 acaggcggca ccagcggcat tggtctgtcg atcgcccagg ccctgctgca ggatgggctg
    14281 aaggtcatca tcaccggccg cgaccccggg aagctggaga cggtcgtcag gtcgctgaag
    14341 atggaggacg accagttcga cgtggccggt tacacctgcg acgtacgcga ccgcgacgcg
    14401 gtgcacgaca tggtggaacg gtgcgccaag gagcacggcg agccgaaggt cctggtcaac
    14461 aacgccggcc gcagcggcgg cggcgtgacc gccgcgatcc ccgacgagtt gtggctggac
    14521 gtcatcaaca ccaacctcaa cagcgtcttc tgggtgaccc gcgaggtcat ccggagcagc
    14581 gacgcgatca agcagccagc cggccggatc atcaacatcg cgtccaccgg cggcaagcag
    14641 ggcgtcccgt acggggcccc gtactcggcg gccaaggccg gtgtcatcgg cttcaccaag
    14701 gcactcgcca aggaattcgc cgcccacggt ggccccaccg tgaacgcggt atgccccggc
    14761 tacgtggaaa cgcccatggc ccaggacatc cgcgccagtt acgccaagct caacaacgtc
    14821 accgaggagc aggtcctcgc cgacttcgag gccaaaatcc ccctcggccg ctactgcacc
    14881 cccgaggagg tggcgggcat ggtgcgctac ctggtcagcc cggcagccgc gtcggtgacc
    14941 gcccaggcac tcaacgtctg cggcggactg ggcagttact gacgcttcga gtggaagagg
    15001 gacacgcgca tgaccatcga tgcatccccc gagtcctccg ccttcggctt cgagggccag
    15061 tcctactacg aacaccggcg gctgcgcctg tatgacgccg tggtcgtcca tgcgtcgaac
    15121 cggctgctgt ggcgctgccc gaagtcacgg ctgctcgagc actacaacga ctggatcacc
    15181 tcccgccacc tggaggtcgg ccccggctcg ggctactacc tggaccactg ccacttcccc
    15241 gcaggcacac ccgagctgac cctgctcgac ctcaaccccg acccgctcaa gttcgccgcg
    15301 caccgcctgc gccgctacac cccgcgctgc gtgcagtcgg acatcctgga acccttgccc
    15361 gacttcgtcg gcagcggatt cacatccatc gcctacaact acgtcatgca ctgcctgccc
    15421 gagccaccgg gcggcaagca catcgtcttc aagcacctgc gcgaggcact cgcgcccgac
    15481 ggcgtcctct tcggcagcac cgtcctgtcc cagggcgtga aacacaccgc cctctcccgc
    15541 cgcttcaaca tcctctacca gcgccagggc tccttccaca accagcatga cagcgtccac
    15601 ggactgcacc aggccctgga ggaacacttc gccagccact ggatcgaggt acgcggcagc
    15661 gtcgcactct tcgcggcccg cgcatcgcac accaccgcgc cccgccgccc cggagcatcc
    15721 ctggaccagc gatgagtgag gagaagcgca tgacgtccgg ggccacctac cgtgatgcgg
    15781 ccattcccct gacggcgctg tggacctcgc ccttcgcgcg gtggggaggc gccctgtccc
    15841 acctctccag ccttgacctg gccgtggccg ccaccggccg ggcactgtcg gagcgcggca
    15901 tcgaccgcga caccatcgag ggcatggtgc tgggctggac cgtgccgcag cccgccatct
    15961 tctacggagc caccacgctc gcggcccgac tgggcatgcc ccaggtctcc ggaccgatgc
    16021 tcaaccaagc ctgcgccacc tccgtcgcgg ccctgcacca ggccgccgcg gcagtaggaa
    16081 caggagtcgg cccacaactg atcgtcacca ccgaccgcac cagcaacggc ccggacctct
    16141 cctggccctc acccgccggt tccgggcagg gaccggtgcg cgagaactgg gtacgcgaca
    16201 gcttctcccg ggaccccgtc accggacaga gcatgctcgc cacagccgaa gccgtcgcgg
    16261 ccgagtgcgg cttcacccgc gacgacctgg atgccctcgc cgtcctgcgc tccgagcagt
    16321 acaccgccgc gctcagcaac gaccgcacct tccagcgtga cttcatggtc ggcatcgaga
    16381 tcgaacagga cgggctcggc accgtacggc tcttgtccga cgaaggcgtg cggccggtca
    16441 cggccgacag cgccggtcaa ctcccgacgg tccgccccgg cggcgtccac accgccgcca
    16501 cgcaaacgca tcccgccgac ggcacagcgg gggccctggt gaccacgaca ccgtgcgccc
    16561 gggaattcgc cgaccgcggc ccgatcgtgc gcctggtcgc atccggattc gcccgcgtgg
    16621 agccggcccg catgcccagg gcactcgttc cggccgcgca ggcggcgctg cacgccgccg
    16681 ggctgaagat cgacacgatg gatgccatca gcacccacaa ccccttcgcg gtgaacgacc
    16741 tgtacttcgc ccgggaaacc ggggtgacgc tggaggccat gaacgcgtcc ggctgcagcc
    16801 ttctcttcgg acatccccaa ggcccgaccg ggctgcggat ggtcacggaa ctcgcacacg
    16861 tactgaaggc acgaggcgga gggctgggac tgttcaccgg gtgcgccgcg ggggacaccg
    16921 cggcagcact gatcatcgaa gtgaccgact gacccggcct cctgctgccc agtgctgggc
    16981 aggcagggac acccagcggg ctgtggcgaa ggaggctttc ggccttcacc acagcccgtt
    17041 cggtttgtgc ctcggcggcc cccttcgggg tacggccccg gcccgcagca gcaaaggtca
    17101 cttcccgtgg ccagccagca ccgtggcgat gccggcctgg gcaatgccgc tctcctggac
    17161 ctgccgtacg gccgcgccct cgcgtgccat ggccgcttct accgcacgca gcgagggccg
    17221 catcagcctc agatgtgcgg ccgtggacga acccggcggc gtccactggt ggatcagccg
    17281 gatggcggcg gggatgagat cctccggctc gacgatgtcg tcgaggagac cgaaggccag
    17341 tgcctgggag gcgctgagcc gggcactgtt catgatcagg tgcagggctc ggggtgcacc
    17401 agcgaggcgg ggcaggaaca ggctcgcggc attggacacg gtgagcccga cactggtctc
    17461 cggccatgag atcgcggcct gagcggtggc gatgcgggcg tcgaagctca gggccatctc
    17521 accggccccg ccgacggcga tgccgttgag ggcggccacg accgggactt ccgtgatgag
    17581 agcggcgcgg gtgatgtcgt tgaacagctc catctccgcc agcaagtcga cttccgggcc
    17641 ggcgacttcg cgcaggtcca ttccggcaga gaaggctttt gcctggccgg tgatcaccac
    17701 tccgcgagcc tggctgccgt cgccgtagtg gcgcagcagc tcggccaggt cccggcgcat
    17761 gccgcgggtc agggcgttga gtttcgccgg acggctcatc gcgatcacag caacatcgct
    17821 gtcgaccgtg acggtcaggt cggcggagct cagcaactgc tgtacgtcgc tcatgcccat
    17881 gcatccgctg cggcgtcgaa cgcaccggtg cgctggtcgt ctccgggacg aagcagctgg
    17941 cgcttctgga tacgggcgga gggggtcatg gggaaggagt cgacgaattc gacataggca
    18001 gggaccttga atttcgcgag gtggcggcgg gcgtgcgcga ggacgctgcg agccgttgcc
    18061 gtggtgggcc ggtagccggg gcgcagctgc aggaaggctt tgggcagctc accgaagagc
    18121 tcgtccggga tgccggcgag cgcggcggcc aggaccgccg ggtgggcttc gaggacgctc
    18181 tcgacctcgg ccgctgcgat gttctcccca ccgcgtcgga tcatgtcctt cagccgcccg
    18241 gcgtgcacca cgctcccggc cgcctcggca cgtccgaggt caccggtgtg gtaccagccg
    18301 ccgcggaacg cccgctcggt actgtccggg ttgttccagt agccattcat catgggcctt
    18361 ccccgcacca ggatctcgcc gatctgccct ggctggacgg ggcgttggcg ctcgtcggcg
    18421 acgaggacct ccttgccgga cggcgggtac cccatcgcgc cgctgcccac ggtggcctcc
    18481 tcaccaggcg gcatgatcaa gtccagtccg ctctcggtgg agccgtacac ctcccgccag
    18541 gccgcacccc agcggtcctc gaacgcatgg tgcaagtcgc gcgggatgcc cgagcacaag
    18601 accagccgca tcgcatgatc gcggtcgccc gagtggggcg gctgcttgta cagcagcatg
    18661 ggcatgctgc ccagcacgta ggtcagcgtg gcccggtgct ggcggacgga gtgccagaag
    18721 ccggaggcgg agaaccgcgg gagcaccacc agcggaacgc cgcccatcag gcacatcacg
    18781 gctttccact ggggatccat gtaggagaac gcctgggccg tcagcacgac gtcgtcggga
    18841 cggaggccgg agtggacagc gatcacccac gccgtgcgca gccagtagtc gtggctgagc
    18901 atgcaggctt tcggaaagcc tgtggtgccg gaggtgtact ggaagttgac ggtgtcgtcc
    18961 gcgtgcgccg acaggcccgg accatccacc ggccggtcgc cgaagccggc cttcagttcg
    19021 cgtagcgtcc ggaccgcaca ggggtgcccg atgctgccgc tcacgtcacg ggccaacggc
    19081 acgcagcctg gggaggccag gaccagcacg gcctgagagt ccctcaggac gtgcgcgagg
    19141 tccgtagcgc cgaagcgggt gttgaccggc accgtgatgg caccggcctt gatggccgcg
    19201 aaccagctca acggccagtc cgccacattg tccatcatga ccgcgacacg gtcacccggt
    19261 ttgacacctt gggcgatcag cgcctgcgcc aaccggtcgg tgcgggtgtc ggtctcggag
    19321 aagctgagcg tcttgtcgcc gcatcggagg aattccttgt cgccgtgcag caacgcggca
    19381 tctttgatga gctcgccgat ggtctcccaa cgcggtcccg cttcggggtg ccgagcgtcg
    19441 atcacaggtt gtgtgggggc ctgaggggcc ggttccatgc ttgtggcctc cgtcgcatca
    19501 ggcggtggcc cttgccaccg gtctccactg gacagcgcac caccggcacc ttgaggggga
    19561 agcaagacag cgtcacgggc tgctctcgcg acttgccctg gccgagcttg tctctttacc
    19621 gggcatgaag aagcagccct caccgtgact acggcaggag ctgacccgac ccaagcagag
    19681 gagagcgcct tgacacaggc cccgcacaag ccggaggaga ccgcggtgtc cgcggcgttg
    19741 ttcgcagaga ttcagcagtt ctatgggcgc cacatgcggg ccatggacga aggccgagtg
    19801 gaggactgga ccggcgactt catgcccgac gcggtcttcg cgaccaacgc ccgacccgag
    19861 ccccagcgcg ggcgggccga gatcgcccga aacgcggagg ccgcagcgcg gcagctgcag
    19921 gagaagggca tcctgcgccg ccactgcgtc accaccctgg aactccagca ggcgagtgga
    19981 ctgacgctcc tggccaagac ctacgccctg atcaccaaga cggtggtggg aggccggtcg
    20041 gagctggagt tcgtgtgtac ctgcgaggac gtgctcgtcc ggaacgaggg ccgatggttc
    20101 atccggcacc gccaggtctt ccgggacgat ctccccaaga ggtgagacga caacgtccca
    20161 acaaccctcg gctggcacaa cgcagcggct ccgcactcag ccaccgctgc gccgcctcac
    20221 accttccagg ggctggccgt cggccacggg acctgcagag gagccggatc agcggtcgtg
    20281 cgcaggaacg gggtccgctc agcggtgtcc agccgagggt ccgcggacag aaccgcctgc
    20341 tgcaacatct gcagctcccg ggagggctcc agccccaact cggtcacgag ggactgccgc
    20401 agctggttga acaccttcag cgcctgcgga cgtctgccgc aacggtagag tgcgagcatc
    20461 agttgacggt ggaatccttc atgctgcgga cactgcgacg ccagtccgct cagctcgctc
    20521 agcacctcat gatgacgccc cagttcgagt tccgcttcga ttctggtttc ctggaccccg
    20581 atacggctct cttccagcct tacgatctca gcctcaagat gcatcccacg ccggacattc
    20641 gccagaggcg gcgccgcaaa gatgtgcaga gcggcgcgga actgctcgac agcagccatg
    20701 ttctcgcccg cttgaaaggc ttgctggccg gccaggcgat gccgttcgta gcgttgcagg
    20761 tccacgttct ccggcgggac gcggaattca tagccgttcg gcgtggtcac caggagctgc
    20821 ttagggcatt cacctggacg gatcttcctc aacagctgcc gcagctggaa cacgtacgtc
    20881 tgcaacgcac tgagcgcgct ccgaggaggc tgctcggccc acagctcttc gatcagtaca
    20941 tcggtgctga ccattctgtt tgcgttgacc agcaggaggg caaggacctg cctggccttg
    21001 ggggcgctcg gcgtccggcg ctcatcgccg accttcagcg tcacatgccc gagaacttcg
    21061 acgtccacag ttatttcacc ccgtcgactg tttgcattta ccgcacagcg ggcagcgggc
    21121 agcgagacga tttcgcatgc aattccctga gtcagttgac gcgtgtgggt cgcgcggctg
    21181 tgcgcgacac atgaaaactc gcttgcatta ccgaccactg aggcgccatt gccgcagcac
    21241 gacacaaaag catggcccct gcatgtgact gaacgtatcc gcacggtaat tacagggtca
    21301 aggactcagg aagcgaaacc ggccacaccg cgccccttcg ttccgcttct ctgccgacac
    21361 cccacccggg agcccttccg cacctgcgtg cgagagtgtg acatcgcacc gcttcctcat
    21421 ctcttccctc tcgtaagggt agagtccagc atcaacgtga accccttcct gcgctgcgcg
    21481 cgcgactgca tgtgatcgcg ggtgtgcgcc gcgcaccgac ggcgcacacc cgccgagtct
    21541 cgcgcgggcc ctccggacgc cctcgatcgg ggaaaggccc gcttttggct ccgctcccag
    21601 caagcggcgt cgggccaggt cagcgcctta ctgcgtatgc cgcacctgcg cacttgccgg
    21661 caaggagagc cgcgacggcg ggttgggtca ggagtatggc gcagcttgtc tgattacagc
    21721 cagatgcacc gtgtccacat cgcgcggatt gcgcgctgtg accgcgaatc gcacaccttc
    21781 tgccgcgtcg agcgcctgca tggctacccg gcaagaccgg gtgcatcact cgtgagccag
    21841 agcctccgca gagggccctc cggaagtagc ccgctcacct gccgaccgag ctcgggcgtc
    21901 cgcattcatc cggtcacgca acgtggcggc gaagtcctcg gccatcgcca gtcgcgcgcg
    21961 cagtgtctcg caccgcgcgt cggccacctt gcggtacgcg tcaagtcgct cacggagtcg
    22021 ctcgcgctcc acaggcgcgg gcggatcatc ctgggcgccg agcctgtcag tgatctccag
    22081 caggtcccgc atctcctcaa gggggaaagc cagcggctta aaatgccgaa tcaccatgag
    22141 ccgactgacg tcggcctgag tgtagagacg gaagccgccc ttgctgcggg cggagggaac
    22201 gatgaggccg acctcttcgt aggcgaggac gtcccagccg cgcagcacct gcacgaaggg
    22261 aaccagtgga gcgttcacag cgcaccccct tcctgcaacc ggctcccttg ttgcgtatgt
    22321 attgcaacaa ggagccggtg ttgtcgcaag gggccccacc agtgccgtgc ggtcaggagc
    22381 ccgcggcagg ccggccttca cgcctccggt gcagcagccc cagcagggcg tcgaggacca
    22441 ggaaggtcag taggggccag cccagcaggg cgccactcca gggcagcggc cgacggctgc
    22501 cgaccttcct gtagcctctc gggcctctcc agtgacgggc gtcacacttg ccctgaggaa
    22561 ctggacagcc tgcggccccg acttctgtac cggtacggct cggtccagtg gaggccgtgt
    22621 ggcgtgcgac gcgatcggga gagtcgacag atggcccaga cacggcaacc cgcttccggt
    22681 acgccggccg gcctgctgcg ccgtgtcctg ccccctcctg ccctgtgcgg gttcctcgtg
    22741 ctgctggtgc tggtgttcgc cgtctcctac gccgtcggcc ggagcgtcgg ccccgtcgcg
    22801 cccgggatgc acggtcccgg gatcaccgag gacggccatg agggcggcgg cacggacgtg
    22861 gaggacgacg acatgggcgg catgaaccac gggagcggac actgatggcc ggcgaaccgg
    22921 cgtccgtggt ggaggtgacc gacctcgcgg tcggcggcat gacctgcgcg gcctgcgtga
    22981 agcgggtgga gaagaagttg
//
