BGC0002366 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002366 (Streptomyces sp. SCSIO 11863)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	23,000	enterocin/neoenterocin A/neoenterocin B	PKS	100%

BGC0002366 - Region 1 - T2PKS

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Location: 1 - 23,000 nt. (total: 23,000 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,001
Label		BGC0002366

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002366	1.00	Polyketide	enterocin, neoenterocin A, neoenterocin B	Streptomyces sp. SCSIO 11863
BGC0000220	0.85	Polyketide	enterocin	Streptomyces maritimus
BGC0000231	0.36	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0002631	0.33	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.33	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.33	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002405	0.31	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000844	0.31	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001075	0.28	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0002347	0.28	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002366	1.00	Polyketide	enterocin, neoenterocin A, neoenterocin B	Streptomyces sp. SCSIO 11863
BGC0000220	0.95	Polyketide	enterocin	Streptomyces maritimus
BGC0000231	0.69	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0002631	0.67	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002405	0.65	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000844	0.64	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001075	0.61	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0002347	0.61	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

QIC03935.1

AMP-binding (20..415): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AYGFVAGHIK
Nearest Stachelhaus code(s):: pNH2-Bz AYNFIAGSTK (47% 8Å match); diOH-Bz AANFVSGAIK (24% 8Å match)
Stachelhaus code match:: 60% (weak)

QIC03937.1

PKS_AT (18..299): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 50.6
Methoxymalonyl-CoA: 31.4
Methylmalonyl-CoA: 28.6
Propionyl-CoA: 21.3
Benzoyl-CoA: 18.7
inactive: 14.1
2-Methylbutyryl-CoA: 11.0
fatty_acid: 6.2
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

QIC03945.1

AMP-binding (35..422): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MDWYLSVLDK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 23000
Starter unit(s):: benzoyl-CoA (Score: 2793.0; E-value: 0)
Malonyl elongations:: 7 (Score: 731.8; E-value: 4.3e-223)
Product molecular weight(s):: benzoyl-CoA_7: 416 Da

QIC03935.1: LIG (Score: 674.3; E-value: 2.2e-205); LIG AAF81733.1_Enterocin_benzoyl-CoA (Score: 1052.0; E-value: 0.0)
QIC03936.1: OXY (Score: 35.8; E-value: 1.1e-11)
QIC03937.1: AT (Score: 418.4; E-value: 4.6e-128); AT AAF81731.1_Enterocin_benzoyl-CoA (Score: 666.0; E-value: 0.0)
QIC03938.1: ACP (Score: 89.9; E-value: 1.8e-28)
QIC03939.1: CLF 7 (Score: 731.8; E-value: 4.3e-223)
QIC03940.1: KS (Score: 717.9; E-value: 8.4e-219)
QIC03941.1: KR C9 (Score: 412.3; E-value: 1.7e-126)
QIC03942.1: MET (Score: 84.8; E-value: 1.3e-26)
QIC03945.1: LIG (Score: 670.0; E-value: 4.6e-204); LIG AAF81723.1_Enterocin_benzoyl-CoA (Score: 1075.0; E-value: 0.0)
QIC03946.1: CYC C1-C18|C2-C19 (Score: 175.7; E-value: 1e-54)