LOCUS       BGC0002369             21486 bp    DNA     linear   BCT 17-APR-2020
DEFINITION  Actinomadura rubteroloni strain RB29 Contig_2, whole genome shotgun
            sequence.
ACCESSION   BGC0002369
VERSION     BGC0002369
KEYWORDS    .
SOURCE      Actinomadura rubteroloni
  ORGANISM  Actinomadura rubteroloni
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
COMMENT     There are two aliases for this strain: '5-2' and 'RB29'
            Bacteria and source DNA available from Dr. Christine Beemelmanns,
            Leibnitz Institute for Natural Product Research and Infection
            Biology, Hans-Knoell-Institute (HKI).
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:26:55
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1668)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 403; E-value: 3e-122)"
                     /gene_functions="biosynthetic-additional (t2pks) HAL
                     (Score: 390.7; E-value: 2e-119)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:CLUSTERS:PRK11259"
                     /locus_tag="BTM25_23770"
                     /product="N-methyltryptophan oxidase"
                     /protein_id="POM23755.1"
                     /sec_met_domain="Trp_halogenase (E-value: 1.1e-09,
                     bitscore: 28.0, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVAHPSEKITYDVIILGSGIAGSLLGTILARHGAKVLLLDAASH
                     PRFAIGESTIPYTLVSIRTLAERYDVPEIATLATFTGNTRAIGPRFGVKRHFGFLLHHE
                     DQAQDPREANQFNTPKQLLHEAAHLFRQDTDSFLFNIAIARGCVARQNFLVTDIDVDDS
                     GVSVAGRDGEYRGRYLVDASGFRSPVAQKYGLREDPCRFKHHSRSIWNHSLNVTPTDDL
                     FDHPRRLTPPVPWYQGTVHHMFERGWAWVIGFDNNKVSRNPLCSVGMTVDPRYYPKPDN
                     LSPEEDFYELAGRFPDIARQFEGMKPVREWTSTGRLQYSSSTTVGDRWLLLSHAAGFLD
                     PLFSRGLSNTTEAVNVIAWRLLRAVKDGDFSADRFGYVDKLQQGLFDYNDSLVNSAFIS
                     WTDYDLWSAVFRMWTTGANSGVLRLQRALSKYRADGREQHLLDLEKAAYPGLYWPDHDG
                     FAELYETMVKQCEAVEAGATTPREAADLLYDRLQAAPFVPKHFGFVERDVQFLHPDPVK
                     FLRMLNWARKHGDPDTYDMIAVNGREVVKARLKGRKLF"
     protocluster    1..21486
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[6506:8974]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 639.4; E-value:
                     4.5e-195)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 416.804"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 458.840"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      6507..8974
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 639.4; E-value:
                     4.5e-195)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 416.804"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 458.840"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..21486
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..21486
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002369"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21486
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1668)
                     /locus_tag="BTM25_23770"
     gene            1869..2492
                     /gene="acrR_1"
                     /locus_tag="BTM25_23780"
     CDS             1869..2492
                     /codon_start=1
                     /gene="acrR_1"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 91.7; E-value: 1.3e-27)"
                     /gene_kind="regulatory"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P0ACS9"
                     /locus_tag="BTM25_23780"
                     /product="HTH-type transcriptional regulator AcrR"
                     /protein_id="POM23756.1"
                     /transl_table=11
                     /translation="MSVADERQPKRQRADAERNRAKILATARRLFSTRGEAVNMDEVAR
                     RAGVGVGTLYRHFPTKEALVRATAQQRFADIVAYYRAQCRDTADPLAAMTELLRHIGEV
                     ESRDLVFSRVVESTLGSDTGPPDEFRTAFEAELMELVDRGQAAGRIREDIAGADLLSVT
                     CGLAAVVHRGSGDWRRYIDIVVAGLSTTGGWPAAPAGRDDAAAR"
     gene            complement(2489..2680)
                     /locus_tag="BTM25_23790"
     CDS             complement(2489..2680)
                     /codon_start=1
                     /inference="ab initio prediction:Prodigal:2.6"
                     /locus_tag="BTM25_23790"
                     /product="hypothetical protein"
                     /protein_id="POM23757.1"
                     /transl_table=11
                     /translation="MPETRFVPTKLAALAANVTEATIRKWASRGKLTRHGTPGRALYDI
                     EELLALRAAAEDRAARRT"
     gene            2888..4441
                     /locus_tag="BTM25_23800"
     CDS             2888..4441
                     /EC_number="2.1.3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 708; E-value: 1.3e-214)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q8GBW6"
                     /locus_tag="BTM25_23800"
                     /product="Methylmalonyl-CoA carboxyltransferase 12S
                     subunit"
                     /protein_id="POM23758.1"
                     /transl_table=11
                     /translation="MPTTADVISELIDRKSAARQSSDSEATRRQHGKGKLTAYERIELL
                     LDKGSFTEIEALRRHRATGFGMERRRPDSDGVVTGWGTVLGRTVFVYAHDFRVFGGALG
                     EAHAQKIHKLMDLAIAAGAPLVSLNDGAGARIQEGVTALAGYGGIFRRNTRASGVIPQI
                     SVMLGPCAGGAAYSPALTDFVFMVRGTAQMFITGPDVVRAVTGEDVTHDELGGAEVHGS
                     KSGVSHFVYDDEEACLQDVRYLLSLLPDNNRQLPPTVPSADAPDRETPVLAEIVPDEPT
                     RSYDVREVVAEIVDDGEHLEVHADWAASVVCTLARLDGHTVGIVANQPARLAGVLDIVS
                     SEKAARFVQFCDAFNIPIVSLVDVPGFLPGVRQEHDGIIRHGAKLLYAYCNATVPRVQV
                     IMRKAYGGAYIVMDSRSIGADLSFAWPSNEIAVMGAEGAAEIVFRRDIAAADDPAAVRA
                     ARIAEYRAELMHPFHAAERGLVDDVIEPGQTRAVLCRALATLRSKHADAPARKHGNPPL
                     "
     gene            4438..4611
                     /locus_tag="BTM25_23810"
     CDS             4438..4611
                     /codon_start=1
                     /inference="ab initio prediction:Prodigal:2.6"
                     /locus_tag="BTM25_23810"
                     /product="hypothetical protein"
                     /protein_id="POM23759.1"
                     /transl_table=11
                     /translation="MTGLRIVRGDPTPVELAALVAVLAAAEQAPPPATALHRPPPLPPV
                     YVPPRSWRAGTR"
     gene            4693..6168
                     /gene="pcpB_3"
                     /locus_tag="BTM25_23820"
     CDS             4693..6168
                     /EC_number="1.14.13.50"
                     /codon_start=1
                     /gene="pcpB_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 523.9; E-value:
                     7.9e-159)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 559.2; E-value: 1.9e-170)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P42535"
                     /locus_tag="BTM25_23820"
                     /product="Pentachlorophenol 4-monooxygenase"
                     /protein_id="POM23760.1"
                     /transl_table=11
                     /translation="MDAPVIVVGAGPTGLVLAAELRLGGVDVIVLERLPERSTRSRGLG
                     YTARVVEMFDQRGLLPRFGSIETSARGHFGGIPLDYSVLEDCHFGARGIPQTQVEQVLE
                     AWAVEAGADIRRGTEVVGLRDDGGTVEVTADTPQGRTVLRARYVVGCDGGRSTVRNLAD
                     FDATGSDATMEMYLADVVGAGVRARQIGERLPGGMVMSAPLGDGVDRIIVCEHGTPPAR
                     GDRSPSFDEVADAWKRLTGESLHTATATWVSAFGDATRQVTRYRKGNVLLAGDAAHTHL
                     PAGGQGLSVSAQDAFNLGWKLAAVAAGRAPDELLDTYHDERHPVGTRLLANTRAQGLIY
                     LGGSEVEPLRAVFEELMRIPDVARHLAGMVSGLDIRYDVGAGDHPLLGRRIPPRKLTTP
                     DGLLTTAEVLHDATAVLLDLADDAALRAEAAPWTGGRLRIVTAAPHDLAPGDPLASGDA
                     LLVRPDGYVAWTGADPIPLSSALDRWLGRPTEK"
     gene            6181..6504
                     /gene="tcmI"
                     /locus_tag="BTM25_23830"
     CDS             6181..6504
                     /codon_start=1
                     /gene="tcmI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 156.6;
                     E-value: 3e-48)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C17/C2-C19 (Score: 180.9; E-value: 5.4e-56)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P39890"
                     /locus_tag="BTM25_23830"
                     /product="Tetracenomycin polyketide synthesis protein TcmI"
                     /protein_id="POM23761.1"
                     /transl_table=11
                     /translation="MHSSLIVARMKPEDNAAVAQLFGAFDQTEMPGLMGTRRRQLFSYR
                     GLYFHLQDFDGDDGGERIEKAKDHPLFQRVSADLRPFIEAYDPATWRSPADAMAERFYQ
                     WSA"
     gene            6507..7754
                     /locus_tag="BTM25_23840"
     CDS             6507..7754
                     /EC_number="2.3.1.-"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-393). E-value:
                     1.2e-53. Score: 174.3. Matches aSDomain:
                     nrpspksdomains_BTM25_23840_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 494.6; E-value:
                     4.1e-150)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     770.8; E-value: 7.3e-235)"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q02059"
                     /locus_tag="BTM25_23840"
                     /product="Actinorhodin polyketide putative beta-ketoacyl
                     synthase 1"
                     /protein_id="POM23762.1"
                     /sec_met_domain="t2ks (E-value: 2.6e-243, bitscore: 797.9,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRRVVITGIGVLAPGGVGVKNFWNLLEEGRTATRPISFFDAGPF
                     RSRVAAEIDLDAEACGLTPQEIRRMDRGAQLAVIAAGEAVADSGLTPDPERTGVVVGSA
                     VGATTSLDEEYRIVSDGGRLDLVDHRYAVPHLYDYFVPSSFSREVAWAVDATGPNTVVS
                     TGCTSGLDSVGYAVELIREGSVDTMVAGASDAPISPITVACFDAIKATTPRNDDPEHAS
                     RPFDASRNGFVLGEGSAMFVLEEYEQARARGAHIYAEIAGFANRCNAYHMTGLRPDGRE
                     MAEAITAALGEARLDATAIDYINAHGSGTRQNDRHETAAFKRSLGDHAYRTPVSSIKSM
                     VGHSLGAIGSIEIAASALAIEHNVVPPTVNLHNPDPECDLDYVPLTAREHRTDVVLTVG
                     SGFGGFQSAMVLRRVA"
     aSDomain        6519..7685
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BTM25_23840_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.20E-53"
                     /label="BTM25_23840_PKS_KS.1"
                     /locus_tag="BTM25_23840"
                     /protein_end="393"
                     /protein_start="4"
                     /score="174.3"
                     /tool="antismash"
                     /translation="VVITGIGVLAPGGVGVKNFWNLLEEGRTATRPISFFDAGPFRSRV
                     AAEIDLDAEACGLTPQEIRRMDRGAQLAVIAAGEAVADSGLTPDPERTGVVVGSAVGAT
                     TSLDEEYRIVSDGGRLDLVDHRYAVPHLYDYFVPSSFSREVAWAVDATGPNTVVSTGCT
                     SGLDSVGYAVELIREGSVDTMVAGASDAPISPITVACFDAIKATTPRNDDPEHASRPFD
                     ASRNGFVLGEGSAMFVLEEYEQARARGAHIYAEIAGFANRCNAYHMTGLRPDGREMAEA
                     ITAALGEARLDATAIDYINAHGSGTRQNDRHETAAFKRSLGDHAYRTPVSSIKSMVGHS
                     LGAIGSIEIAASALAIEHNVVPPTVNLHNPDPECDLDYVPLTAREHRTD"
     gene            7751..8974
                     /locus_tag="BTM25_23850"
     CDS             7751..8974
                     /EC_number="2.3.1.-"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (74-404). E-value:
                     2.4e-29. Score: 94.3. Matches aSDomain:
                     nrpspksdomains_BTM25_23850_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 621.2; E-value:
                     1.1e-188)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 639.4; E-value: 4.5e-195)"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q02062"
                     /locus_tag="BTM25_23850"
                     /product="Actinorhodin polyketide putative beta-ketoacyl
                     synthase 2"
                     /protein_id="POM23763.1"
                     /sec_met_domain="t2clf (E-value: 3.4e-191, bitscore: 625.7,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAIATRRAEVVVTGLGVTAPNGLGTADYWAATCAGVGGIGPVRR
                     FDASGYPSALAGEVPGFAAEEHLASRLLPQTDHMTRLALVTADFALADAGVSPGEWSDY
                     DLGVVTASSAGGFEFGQRELQALWSKGGRHVSAYQSFAWFYAVNTGQISIRHSMRGPCG
                     VVVSDHAGGLDAVAQARRQVRRGTSRLMLSGGVDGAVCSWGWVAQLASRRLSPDGYRPF
                     DATASGYVPGEGGAFLVLEAAEPARERGARPYGRIAGYGSTFDPRPDARDREPGLRRAI
                     GLALDDAGITPADVDVVFADAAGVRELDAAEAAAIGAVFGRHGVPVTAPQTMTGRLYAG
                     AAALQVACALLAIRDGIVPPTTGTDPMPEYGLDLVVGEARRRPVRTALVLARGYDGNNS
                     ALIVREEV"
     aSDomain        7973..8962
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BTM25_23850_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.40E-29"
                     /label="BTM25_23850_PKS_KS.1"
                     /locus_tag="BTM25_23850"
                     /protein_end="404"
                     /protein_start="74"
                     /score="94.3"
                     /tool="antismash"
                     /translation="QTDHMTRLALVTADFALADAGVSPGEWSDYDLGVVTASSAGGFEF
                     GQRELQALWSKGGRHVSAYQSFAWFYAVNTGQISIRHSMRGPCGVVVSDHAGGLDAVAQ
                     ARRQVRRGTSRLMLSGGVDGAVCSWGWVAQLASRRLSPDGYRPFDATASGYVPGEGGAF
                     LVLEAAEPARERGARPYGRIAGYGSTFDPRPDARDREPGLRRAIGLALDDAGITPADVD
                     VVFADAAGVRELDAAEAAAIGAVFGRHGVPVTAPQTMTGRLYAGAAALQVACALLAIRD
                     GIVPPTTGTDPMPEYGLDLVVGEARRRPVRTALVLARGYDGNNSALIVR"
     CDS_motif       8414..8452
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BTM25_23850_0001"
                     /evalue="4.20E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="BTM25_23850"
                     /protein_end="234"
                     /protein_start="221"
                     /score="13.4"
                     /tool="antismash"
                     /translation="FDATASGYVPGEG"
     gene            8978..9241
                     /locus_tag="BTM25_23860"
     CDS             8978..9241
                     /NRPS_PKS="Domain: ACP (10-79). E-value: 1.8e-14. Score:
                     45.7. Matches aSDomain: nrpspksdomains_BTM25_23860_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 110; E-value:
                     7.6e-34)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 113.6; E-value: 7.5e-36)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q02054"
                     /locus_tag="BTM25_23860"
                     /product="Actinorhodin polyketide synthase acyl carrier
                     protein"
                     /protein_id="POM23764.1"
                     /sec_met_domain="PP-binding (E-value: 4.6e-11, bitscore:
                     33.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLTIDDLRRILREAAGDVQDIDLDGDVMDLEFEAIGYDSLALL
                     EAGSRIERAHGITLDDGLISEAATPRDLLTAVNEVLAEADAA"
     aSDomain        9008..9214
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BTM25_23860_ACP.1"
                     /evalue="1.80E-14"
                     /label="BTM25_23860_ACP.1"
                     /locus_tag="BTM25_23860"
                     /protein_end="79"
                     /protein_start="10"
                     /score="45.7"
                     /tool="antismash"
                     /translation="RILREAAGDVQDIDLDGDVMDLEFEAIGYDSLALLEAGSRIERAH
                     GITLDDGLISEAATPRDLLTAVNE"
     gene            9238..10020
                     /gene="actIII"
                     /locus_tag="BTM25_23870"
     CDS             9238..10020
                     /EC_number="1.3.1.-"
                     /NRPS_PKS="Domain: PKS_KR (6-160). E-value: 1.6e-12. Score:
                     39.5. Matches aSDomain:
                     nrpspksdomains_BTM25_23870_PKS_KR.1"
                     /codon_start=1
                     /gene="actIII"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     254.6; E-value: 1.5e-77)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 471.1; E-value: 2e-144)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P16544"
                     /locus_tag="BTM25_23870"
                     /product="putative ketoacyl reductase"
                     /protein_id="POM23765.1"
                     /sec_met_domain="adh_short (E-value: 1.2e-40, bitscore:
                     129.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGAARTAIVTGATSGIGLACVRLLAETGHRVYLCARTPESVAAT
                     VKELTGEGLDVDGRACDVTSAADIAAFVGAAVERYGPVGVLVNNAGRSGGGVTADIADE
                     LWDAVIDTNLNSVFRMTREVLTTGGMRNLDRGRIVNIASTAGKQGVVLGAPYSASKHGV
                     VGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRAGYAAAWDTSEDEILRKFQAKIPL
                     GRYSTPEEVAGLVGYLVTDPASSITAQALNVCGGLGNF"
     aSDomain        9256..9717
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BTM25_23870_PKS_KR.1"
                     /evalue="1.60E-12"
                     /label="BTM25_23870_PKS_KR.1"
                     /locus_tag="BTM25_23870"
                     /protein_end="160"
                     /protein_start="6"
                     /score="39.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TAIVTGATSGIGLACVRLLAETGHRVYLCARTPESVAATVKELTG
                     EGLDVDGRACDVTSAADIAAFVGAAVERYGPVGVLVNNAGRSGGGVTADIADELWDAVI
                     DTNLNSVFRMTREVLTTGGMRNLDRGRIVNIASTAGKQGVVLGAPYSASK"
     CDS_motif       9262..9330
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BTM25_23870_0001"
                     /evalue="9.80E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="BTM25_23870"
                     /protein_end="31"
                     /protein_start="8"
                     /score="18.2"
                     /tool="antismash"
                     /translation="IVTGATSGIGLACVRLLAETGHR"
     gene            10051..10989
                     /locus_tag="BTM25_23880"
     CDS             10051..10989
                     /NRPS_PKS="Domain: Polyketide_cyc2 (8-150). E-value: 1e-16.
                     Score: 53.4. Matches aSDomain:
                     nrpspksdomains_BTM25_23880_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (158-298). E-value:
                     3e-11. Score: 35.8. Matches aSDomain:
                     nrpspksdomains_BTM25_23880_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 443.7; E-value:
                     6.1e-135)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 469.6; E-value: 8.2e-144)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P23154"
                     /locus_tag="BTM25_23880"
                     /product="putative polyketide cyclase"
                     /protein_id="POM23766.1"
                     /transl_table=11
                     /translation="MTTKPAERVVEHETTIEADADLVYGLLARAEDWPHVFPPSVYVER
                     VPEGGGAERIRIWATANGEVRNWTSRRLVDPAARRIEFRQEVSSPPVAAMGGTWTVEPG
                     PGGTCRVVLGHDYRAVDDDPHDLLWIDRAVDRNSRSELASLKRHAELAAADLVFSFTDA
                     VQIDGAAADAFAFVNEAALWPERLPHVARAELTETTPGLQTLKMDTRAKDGSTHTTESV
                     RVCFPHHKIVYKQTTVPALMAAHTGTWLFRDDGAGSTASSEHTVVLNPDTVEKVLGAGA
                     TVADARAYVQGALSANSLATLGHARTFAESR"
     aSDomain        10075..10500
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BTM25_23880_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.00E-16"
                     /label="BTM25_23880_Polyketide_cyc2.1"
                     /locus_tag="BTM25_23880"
                     /protein_end="150"
                     /protein_start="8"
                     /score="53.4"
                     /tool="antismash"
                     /translation="VVEHETTIEADADLVYGLLARAEDWPHVFPPSVYVERVPEGGGAE
                     RIRIWATANGEVRNWTSRRLVDPAARRIEFRQEVSSPPVAAMGGTWTVEPGPGGTCRVV
                     LGHDYRAVDDDPHDLLWIDRAVDRNSRSELASLKRHAE"
     aSModule        10075..10944
                     /domains="nrpspksdomains_BTM25_23880_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_BTM25_23880_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="BTM25_23880"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        10525..10944
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BTM25_23880_Polyketide_cyc2.2"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.00E-11"
                     /label="BTM25_23880_Polyketide_cyc2.2"
                     /locus_tag="BTM25_23880"
                     /protein_end="298"
                     /protein_start="158"
                     /score="35.8"
                     /tool="antismash"
                     /translation="SFTDAVQIDGAAADAFAFVNEAALWPERLPHVARAELTETTPGLQ
                     TLKMDTRAKDGSTHTTESVRVCFPHHKIVYKQTTVPALMAAHTGTWLFRDDGAGSTASS
                     EHTVVLNPDTVEKVLGAGATVADARAYVQGALSANS"
     gene            10991..12127
                     /gene="pcpB_4"
                     /locus_tag="BTM25_23890"
     CDS             10991..12127
                     /EC_number="1.14.13.50"
                     /codon_start=1
                     /gene="pcpB_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 414.4; E-value:
                     1.3e-125)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 432.4; E-value: 5.6e-132)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P42535"
                     /locus_tag="BTM25_23890"
                     /product="Pentachlorophenol 4-monooxygenase"
                     /protein_id="POM23767.1"
                     /transl_table=11
                     /translation="MGTDTGADVIVVGAGPVGLLLAGGLRAAGVRAVVLERRTAPMDES
                     RASTLNARTMEVLAELGALSRLGGLPREPRGHFGGLPLDLGAVGGTPYPGQWKIPQTVL
                     EAKLGAWLAELGVPVRRGAAAEALEQDAAGVTVTASDGTAVRGSYVVGCDGVGSTVRAL
                     AGIAFPGRAAGRELLRADVRGVDVRDRRFERLPAGLAIAATRDGVTRLMTHAFGTPARD
                     RGGPPDFAEFAATWKRVTGEDVSGGEPLWCDAFGDASRLAERYRAGRVLLAGDAAHEQM
                     PVGGQALNLGLQDAAALVPRLAAAVAGVSGDALLDAYAAGRHAVGARVQRDVEAQTLLL
                     LGGPEVTPVRTVLAELLERPPVREFLAAGVSGVAEGVR"
     gene            12124..13419
                     /gene="nhaS3_1"
                     /locus_tag="BTM25_23900"
     CDS             12124..13419
                     /codon_start=1
                     /gene="nhaS3_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 410.3; E-value:
                     1.3e-124)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q55190"
                     /locus_tag="BTM25_23900"
                     /product="High-affinity Na(+)/H(+) antiporter NhaS3"
                     /protein_id="POM23768.1"
                     /transl_table=11
                     /translation="MSAHAADMRIAVMLAGIALVLLAGLVFGRIARAVRQPAVVGELVA
                     GIALGPSLLGALPGDPSHRIFPDDVRPLLSAVAQVGLVLFMFAVGWEFEKRLIRGNVGA
                     AIGVSVSSAVLAFGLGVGAAAVLYARHDTVAGKHVGFLPFALFLGIALSVTAFPVLARM
                     LAESSLADTRIGAVALAGAAIDDVLAWFLLAYVSALVSADGSGSGLARIAVLFALYLAV
                     MAAVVRPLLSRIVWRWAATERWPALLTLLCAGVFLSSWVTTWIGVHAIFGAFLFGFVMP
                     REPARVLAEHVRRPLDDVILLLLPVFFIVTGLNVDVGALDGPGLLELALVLVCACAGKI
                     GGALVPARLAGLGWRDATTLGLLMNTRGLTELIILNAAMSLGVLDGRMFTVLVLMAVLT
                     TAMTGPFLPRRAGAADPPVLVPARPTKGAGHP"
     gene            13416..13946
                     /gene="ntaB"
                     /locus_tag="BTM25_23910"
     CDS             13416..13946
                     /EC_number="1.5.1.42"
                     /codon_start=1
                     /gene="ntaB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 133.1; E-value: 1.2e-40)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P54990"
                     /locus_tag="BTM25_23910"
                     /product="FMN reductase (NADH) NtaB"
                     /protein_id="POM23769.1"
                     /transl_table=11
                     /translation="MTTARPSDGLVDAAALRRTCGLFATGVTVITSAHGGMTAGTTVNS
                     FTSVSLDPPLVLFCLHRESRLHEIITGSRAFAVNLLHAEQGTLAHAFARRSTAVLDEVD
                     HRRTPSGTPVFAESLAYLDCRLAAEYGGGDHSILVGEVVDLAIHDAGSDPLVFFGGSLH
                     SLDNPLRRRAGLR"
     gene            13943..15715
                     /gene="accC_1"
                     /locus_tag="BTM25_23920"
     CDS             13943..15715
                     /EC_number="6.3.4.14"
                     /codon_start=1
                     /gene="accC_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     648.1; E-value: 2.9e-196)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P37798"
                     /locus_tag="BTM25_23920"
                     /product="Biotin carboxylase"
                     /protein_id="POM23770.1"
                     /sec_met_domain="ATP-grasp (E-value: 3.1e-10, bitscore:
                     30.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPMRRVLIANRGEIAVRIARACRDAGLVSIAVYAEQDVDALHVR
                     AADEAYALGGRSPAETYLDIAGLLAVAARADADAVHPGYGFLAENADFATAVAAAGLTW
                     IGPPPAAIAALGDKVAARDIARRVNAPLAPGTDGPVADAEEVLEFARRHGLPVALKAAF
                     GGGGRGLRVARTLAEIPAAFEAATREAVAAFGRGECFVERYLENCRHVETQCLADRHGN
                     VMVVSTRDCTLQRRHQKLVEEAPAPFLTDEQTGQLVSASRAVLREAGYVGAGTCEFLLA
                     PDGTIAFLEVNTRLQVEHPVTEEVTGIDLVREMFRIADGGVLEPSDPPVRGHAIEFRLN
                     AEDAGRGFLPAAGTLTRFRPPSGPGVRMDAGYVEGAAVPAEFDSLIGKLIVTGRTRREA
                     IERSRRALAELEVAGIPTVVPFHRALLADEAFTGEPFTVHTRWIETEFSGAVPPHADAP
                     DAPADDAGHRRVTVEVGGRRLEVVLRDALGAALVPAAGRPAPARAARRAGPAGAGGDAL
                     VSPMQGTVVKVLVADGAPVAAGDTVLVLEAMKMEQGLTAHRSGTVRDLSAQAGATVAAG
                     AAVCRIVDPPAPEA"
     gene            15835..17319
                     /gene="efpA_3"
                     /locus_tag="BTM25_23930"
     CDS             15835..17319
                     /codon_start=1
                     /gene="efpA_3"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 405.5; E-value:
                     3.9e-123)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:O05813"
                     /locus_tag="BTM25_23930"
                     /product="putative MFS-type transporter EfpA"
                     /protein_id="POM23771.1"
                     /transl_table=11
                     /translation="MASPETPALKPPRTSAPGRVYKPGIVLAFICVAQFMVFLDVTVVN
                     VALAHIQKSLDMAETDLQYIVTAYGTVLGGFLLLGGRLADVVGRRRMLQIGLFLFAASS
                     LVAGVSQSPGVLIGARGFQGLGSALIAPAALSILTSTFKEGPERTRALGIWGALTGLAS
                     VAGVLLGGILTQGPGWRWIFFINVPIGIIAVLLAPLLAPESRDTERRHRIDVTGAILLT
                     TGLLLLIYTLNETVNRGWGDGRTIGGLAGAAVLLAAFLIVEGRTKEPLMPLGIFRNTAM
                     RTANLATVLLFGSTVTLFFFASLFMQVVLGYSALKTGLAYVPLALVVAIAAGIASTLTT
                     KIAAKPVMLTGMFLSAAGLVMLARLPKDGSYLTHVLPAFIVAGAGLGASFVTLQVAAFI
                     GVRQHEAGLAAGLINTSQEGGGALGVAVVATAAFAKIKDLRDAAAGNADRIKDAQASGF
                     HEAFVIGAGFAVTALVLALVLLPMMRASERPDTVIG"
     gene            17343..17741
                     /locus_tag="BTM25_23940"
     CDS             17343..17741
                     /codon_start=1
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF01243.14"
                     /locus_tag="BTM25_23940"
                     /product="Pyridoxamine 5'-phosphate oxidase"
                     /protein_id="POM23772.1"
                     /transl_table=11
                     /translation="MTNIVKLTRRAETFVSDAQVGVLTTLRPDGTPHSVPVCFTFDPGA
                     GLVRVLTRAASRKARNVIESPGGRATICQVAGPKFLSMEGTAEVSGERARVEEGARWYA
                     KRYAYAPPSPPDRVVIEIAVDRVLDGIS"
     gene            complement(17734..18192)
                     /locus_tag="BTM25_23950"
     CDS             complement(17734..18192)
                     /codon_start=1
                     /inference="ab initio prediction:Prodigal:2.6"
                     /locus_tag="BTM25_23950"
                     /product="hypothetical protein"
                     /protein_id="POM23773.1"
                     /transl_table=11
                     /translation="MKQMHSDLTNIDRTDVAELLARYLIGLDADPLDDDWAGGLFTADA
                     VVEFPMSAHRGLAGMAGYHRDALGNFAATQHLGSPPAVQVAGDRAGLRANLTSTHVHHA
                     TRDGGPPEFFRTGTLVDGDAVRTDAGWRLTRLSFRVQWMDGRPPAGSS"
     gene            18292..19809
                     /gene="pcpB_5"
                     /locus_tag="BTM25_23960"
     CDS             18292..19809
                     /EC_number="1.14.13.50"
                     /codon_start=1
                     /gene="pcpB_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 536.3; E-value:
                     1.3e-162)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 514.6; E-value: 6.2e-157)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P42535"
                     /locus_tag="BTM25_23960"
                     /product="Pentachlorophenol 4-monooxygenase"
                     /protein_id="POM23774.1"
                     /transl_table=11
                     /translation="MDDENPRVVIVGAGPTGLMLAGELALAGIPALLVDRLAEPMQQSR
                     ALGFSARTIEEFDQRGLLPRFGTLETLPFGHFGGFFMDFTAVDNGSYGARGVHQARTEA
                     VLTAWIGELGVKIHREHEVTGLGTDADGVTVRMRTPDGEREVRAEYVVGCDGARSTVRN
                     LAGIGFPGTEATVEVWLADVSGPELRPRFAGERVDGGMVMVLPLGDGVNRIVAYERAMA
                     PTGRTTPPSFTEVADRFERLTGGERVHDGEALWVSWFTDASRQAERYRDGRVFVAGDAA
                     HVHLPIGAQGMSAGVQDAVNLGWKLAAVLKGDAPDALLDTYHAERHPVGARIVANTLVQ
                     RFLYLDGDAMQPLRDVFGELMFYPDVQRHLIGMVTGLDVRYDVGPGSHPLLGRRLPNEE
                     LVLPDRKTTNYDLLHNGRGVLLILDDSAGLSARAEPWADRLDIIRADQHDCKAPLDALL
                     VRPDGYVAWLTPGTDDGADLTTALTRWFGPDPSSTSTSESSTSESES"
     gene            19810..20520
                     /locus_tag="BTM25_23970"
     CDS             19810..20520
                     /codon_start=1
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="protein motif:Pfam:PF03992.10"
                     /locus_tag="BTM25_23970"
                     /product="Antibiotic biosynthesis monooxygenase"
                     /protein_id="POM23775.1"
                     /transl_table=11
                     /translation="MPTFAADGKYLTVLNLFTTDTDEKQGKLIGAMRDVVDNAAYPGWI
                     SSTVHSGKESPGTANFIQWRSGEDLEARYAGEEFKHRTLPLFREITTSIKLLQTDVVYT
                     QRAPEQTEIEIGPDRDDFTVIQVIGATEGGLDDLVEALGAGHAWLRDVPGYRSHTVLRG
                     RAARGLDGPFAVVYSQWDDEASFAAFRAVSADEQSAERRAATERVEASSTFHDWNTYQV
                     VHTRSAAAPTGSAV"
     gene            20791..21486
                     /gene="srrA"
                     /locus_tag="BTM25_23980"
     CDS             20791..21486
                     /codon_start=1
                     /gene="srrA"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 170.7; E-value: 5.7e-52)"
                     /gene_kind="regulatory"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q9L524"
                     /locus_tag="BTM25_23980"
                     /product="Transcriptional regulatory protein SrrA"
                     /protein_id="POM23776.1"
                     /transl_table=11
                     /translation="MLVVEPDCRTAEHLVHWLVRHGYEVDLVDTGRRTLEVAATADLVL
                     LDLGLPDLDGIEVCRSLRDRTDAPLITFTGAGTELDRVLSLQAGADDCMVKPYGLRELV
                     ARMEAVMRRVLPHGRGVRGLIAHGTLEIDLDRRQVRVRGGDVELTRKEFELLRILASRP
                     ESVITRRELMSRVWEDDWAASTRTIDTHVSSLRHKLGDAEWIVTVRGVGYRLGSGSLTD
                     AAAQVQPLV"
ORIGIN
        1 tcagaagagt ttgcggccct tcaggcgggc cttgacgacc tcgcggccgt tgacggcgat
       61 catgtcgtag gtgtcggggt cgccgtgctt gcgggcccag ttgagcatgc gcaggaactt
      121 caccgggtcg gggtggagga actggacgtc gcgctccacg aagccgaagt gcttcgggac
      181 gaacggcgcg gcctggaggc ggtcgtagag gaggtccgcc gcctcgcggg gtgtcgtggc
      241 gccggcttcc acggcctcgc actgcttgac catcgtctcg tacagttcgg cgaagccgtc
      301 gtggtcgggc cagtagaggc cggggtaggc ggccttctcc aggtcgagaa ggtgttgttc
      361 gcggccgtcc gcgcggtatt tgctgagcgc gcgctggagg cgcaggacgc ccgagttcgc
      421 gcccgtcgtc cacatgcgga agacggccga ccacaggtcg tagtcggtcc aggagatgaa
      481 ggccgagttc accagcgagt cgttgtagtc gaacaggccc tgctggagct tgtcgacgta
      541 gccgaaccgg tcggcggaga agtcgccgtc cttgacggcc cgcaggagac gccacgcgat
      601 gacgttgacg gcctcggtgg tgttcgacag gccgcgcgag aacagcgggt cgaggaagcc
      661 ggccgcgtgg gacagcagca gccaccggtc gccgacggtc gtgctggacg agtactggag
      721 ccgtcccgtc gacgtccact cccggacggg cttcatgccc tcgaactgcc gggcgatgtc
      781 ggggaaccgt cccgccagct cgtagaagtc ctcctcgggc gagaggttgt cgggcttcgg
      841 gtagtagcgc gggtcgacgg tcatcccgac gctgcacagc gggttgcgcg acaccttgtt
      901 gttgtcgaac ccgatgaccc acgcccagcc gcgctcgaac atgtggtgga cggtcccctg
      961 gtaccacggg acgggcgggg tgagccggcg cgggtggtcg aacaggtcgt cggtcggcgt
     1021 gacgttcagc gagtggttcc agatcgaccg cgagtggtgc ttgaagcggc acgggtcctc
     1081 gcgcaggccg tacttctggg cgaccgggga gcggaacccg ctcgcgtcca cgaggtagcg
     1141 gccccggtac tcgccgtcgc gcccggcgac cgacaccccc gagtcgtcga cgtcgatgtc
     1201 ggtgaccagg aagttctgcc gcgcgacgca gccgcgggcg atcgcgatgt tgaacaggaa
     1261 cgagtcggtg tcctgccgga acaggtgggc cgcctcgtgc aggagctgct tcggcgtgtt
     1321 gaactggttg gcctccctcg ggtcctgcgc ctggtcctcg tggtggagca ggaatccgaa
     1381 gtggcgcttc acgccgaaac gcgggccgat ggcccgggta ttgccggtga acgtcgcgag
     1441 cgtcgcgatc tcggggacgt cgtaacgttc ggcgagcgtg cgaatggaga ccagggtgta
     1501 ggggatcgtg gattcgccga tcgcgaaccg gggatgcgat gcggcatcga gcaggagcac
     1561 cttggccccg tgccgcgcca gaatcgtccc gaggagggat ccggcgattc ccgaacccag
     1621 aatgatgacg tcgtaggtga tcttttcgga agggtgagcc acggccatgc ggacctccgc
     1681 cgtttcgcct gtaaagccat cttttctaca cggcggcgga cgagacaagg cattgaatgc
     1741 aagatctgcg gacacttcca cagagccgcg tgggccccat gtcaggcgaa ggtgaaattc
     1801 ccttctcagc ggcctgcgac gggcctcgcc gggcaccgtg tagactccca gacggaagga
     1861 gattccggat gtctgtggcc gacgagcgcc agcccaagcg ccagcgggcg gacgccgagc
     1921 gcaaccgtgc gaagatcctc gcgacggcgc gccggctgtt cagcacgcgc ggcgaggccg
     1981 tcaacatgga cgaggtcgcg cgccgtgcgg gcgtcggcgt cggcaccctg taccggcact
     2041 tcccgaccaa ggaggcgctg gtccgcgcca ccgcgcagca gcggttcgcc gacatcgtgg
     2101 cgtactaccg cgcgcagtgc cgcgacaccg ccgatcccct ggccgcgatg accgagctgc
     2161 tgcgccacat cggcgaggtg gagagccgtg acctggtgtt ctcccgcgtg gtggagagca
     2221 cgctcggctc cgacaccggg ccgccggacg agttccgcac cgccttcgag gccgagttga
     2281 tggagctggt ggaccggggc caggccgccg ggcggatccg ggaggacatc gccggcgccg
     2341 acctgctgtc ggtcacctgc ggcctcgccg cggtcgtcca ccggggcagc ggcgactggc
     2401 gccgctacat cgacatcgtc gtcgccgggc tgagcacgac cggcggctgg ccggccgcgc
     2461 ccgccggccg ggacgacgcc gccgcccgct aggtccgccg cgccgcccgg tcctccgccg
     2521 ccgcgcgcag ggcgagcaac tcttcgatgt cgtaaagggc gcgtcccggc gtcccgtgcc
     2581 gtgtcagctt gcctctgctc gcccatttcc tgatggttgc ctccgtaacg ttcgcggcga
     2641 gtgccgccag ctttgtcggg acgaaccgtg tttccggcat gtgaacttcc tgttgagaga
     2701 aactgaaccg ctgcgggcag acgaaagggg ggtcaggaac cgtcgaaagg agtttgacac
     2761 gattcccggc ggtgtgtcac actttcgaca gcggcggagc catgcccgaa cggccgtgcg
     2821 ggtcccactc tatgatcccg gccccatcct cccgccgaga agttcctgat tcctacagga
     2881 gtcactcgtg cccacaactg ctgacgttat ctccgaactg atcgaccgta agtcggccgc
     2941 acgccagagt tccgattccg aagccaccag aagacagcac ggtaaaggaa agctcaccgc
     3001 ctacgaacgg atcgagctgc tcctggacaa gggttccttc accgagatcg aggccctgcg
     3061 acggcaccgc gccacgggct tcggcatgga gcgccgccgg cccgactccg acggggtcgt
     3121 gaccggctgg ggcaccgtgc tcggccgcac cgtcttcgtc tacgcgcacg acttccgcgt
     3181 gttcggcggg gcgctcggcg aggcgcacgc ccagaagatc cacaagctga tggacctggc
     3241 catcgcggcc ggcgcgccgc tggtgagcct caacgacggc gcgggcgccc gcatccagga
     3301 gggcgtcacg gcgctcgcgg ggtacggcgg gatcttccgc cgcaacacgc gggcgtccgg
     3361 cgtgatcccg cagatcagcg tgatgctcgg cccgtgcgcg ggcggcgccg cgtactcgcc
     3421 ggcgctgacc gacttcgtgt tcatggtgcg gggcaccgcg cagatgttca tcaccggccc
     3481 cgacgtggtg cgggcggtga ccggcgagga cgtcacccac gacgagctgg gcggcgcgga
     3541 ggtccacggg tcgaagtccg gcgtctcgca cttcgtgtac gacgacgagg aggcgtgcct
     3601 ccaggacgtc cgctacctgc tgtcgctgct gcccgacaac aaccggcagc tcccgccgac
     3661 cgtgccgagc gcggacgcgc ccgaccgcga gacgccggtg ctcgccgaga tcgtcccgga
     3721 cgagcccacg cgctcctacg acgtccgcga ggtcgtcgcg gagatcgtgg acgacggcga
     3781 gcacctggag gtccacgcgg actgggcggc gagcgtcgtc tgcacgctcg cgcggctcga
     3841 cggccacacg gtcgggatcg tggcgaacca gcccgcgcgg ctcgcgggcg tgctcgacat
     3901 cgtctccagc gagaaggcgg cgcggttcgt gcagttctgc gacgcgttca acatcccgat
     3961 cgtcagcctg gtggacgtgc cgggcttcct cccgggcgtc cggcaggagc acgacgggat
     4021 catccggcac ggcgcgaaac tgctgtacgc gtactgcaac gcgaccgtcc cgcgcgtcca
     4081 ggtcatcatg cgcaaggcct acggcggggc gtacatcgtc atggactccc ggtccatcgg
     4141 cgccgacctg tcgttcgcgt ggccgtccaa cgagatcgcg gtgatgggcg ccgagggcgc
     4201 ggccgagatc gtcttccgcc gggacatcgc ggcggccgac gacccggcgg ccgtgcgcgc
     4261 cgcgcgcatc gccgagtaca gggccgagct gatgcacccg ttccacgccg ccgagcgcgg
     4321 cctggtggac gacgtcatcg agccgggcca gacccgggcc gtcctgtgcc gggcgctcgc
     4381 gacgctgcgc tccaagcacg ccgacgcgcc ggcccgcaag cacgggaatc ccccgctgtg
     4441 accgggctgc gcatcgtccg gggcgacccg acgccggtgg agctggccgc gctcgtcgcc
     4501 gtcctcgcgg cggccgagca ggccccgccg cccgcgacgg ccctccaccg ccccccaccg
     4561 ctcccgcccg tgtacgtccc gccccggagc tggcgcgccg ggacgcgctg acaccgcccg
     4621 cgcaaggccg gaccgacccg ctcggtccgg ccttgcgcgt tcccgaaacc ctttcgcgac
     4681 aaggaggcgt cgatggacgc accggtcatc gtggtcggcg cgggtcccac cgggctcgtg
     4741 ctggccgccg agctgcggct cggcggcgtg gacgtgatcg tgctggaacg gctgcccgag
     4801 cgctccaccc gctcgcgcgg cctcggctac accgcccggg tggtggagat gttcgaccag
     4861 cgcgggctgc tcccccggtt cggttcgatc gagacgagcg cgcgcggcca cttcggcggc
     4921 atcccgctcg actacagcgt gctggaggac tgccacttcg gcgcgcgcgg catcccgcag
     4981 acgcaggtcg agcaggtcct ggaggcgtgg gccgtcgagg cgggcgccga catccggcgc
     5041 ggcaccgagg tggtgggcct gcgcgacgac ggcggcaccg tcgaggtcac cgccgacacc
     5101 ccgcagggcc ggacggtcct gcgcgcccgc tacgtcgtcg gctgcgacgg cggccggagc
     5161 accgtccgca acctggccga cttcgacgcc accggctcgg acgcgacgat ggagatgtac
     5221 ctcgccgacg tcgtgggcgc gggcgtccgc gcccggcaga tcggcgagcg cctccccggc
     5281 ggcatggtca tgtcggcgcc gctcggcgac ggcgtggacc gcatcatcgt gtgcgagcac
     5341 gggacgccgc ccgcgcgcgg cgaccgcagc ccgtccttcg acgaggtcgc cgacgcgtgg
     5401 aagcggctca ccggcgagtc gctgcacacg gcgacggcca cctgggtcag cgcgttcggc
     5461 gacgcgacgc ggcaggtcac gcggtaccgg aaggggaacg tgctgctggc gggcgacgcc
     5521 gcgcacacgc acctcccggc gggcggccag ggcctgagcg tcagcgccca ggacgcgttc
     5581 aacctcggct ggaagctcgc ggccgtcgcg gcgggacgcg cgccggacga gctgctcgac
     5641 acctaccacg acgagcggca ccccgtcggg acgcggctgc tcgccaacac gcgcgcccag
     5701 ggcctcatct acctcggcgg cagcgaggtg gagccgctgc gggcggtgtt cgaggagctg
     5761 atgcggatcc cggacgtcgc ccgtcatctg gccggcatgg tcagcgggct ggacatccgc
     5821 tacgacgtcg gcgcgggcga ccacccgctc ctcggacgcc ggatcccgcc gcgcaagctc
     5881 accacgcccg acgggctcct cacgacggcc gaggtgctgc acgacgcgac ggccgtcctg
     5941 ctcgacctcg ccgacgacgc cgcgctgcgc gccgaggccg cgccctggac cggcggacgg
     6001 ctccggatcg tcaccgcggc cccgcacgac ctcgcccccg gcgacccgct cgcgtccggc
     6061 gacgccctgc tcgtccggcc ggacggctac gtcgcctgga ccggcgccga cccgatcccg
     6121 ctgagcagcg cgctggaccg ctggctcgga cgacccacag agaaatagga gacccctggc
     6181 atgcacagca gcctcatcgt cgcccgcatg aagccggagg acaacgccgc cgtggcgcag
     6241 ttgttcggcg cgttcgacca gaccgagatg cccggcctga tgggcacccg caggcggcag
     6301 ctcttctcct accggggcct gtacttccac ctccaggact tcgacggcga cgacggcggc
     6361 gagcgcatcg agaaggcgaa ggaccacccg ctcttccagc gcgtcagcgc cgacctgcgg
     6421 cccttcatcg aggcctacga cccggcgacc tggcgatccc cggcggacgc gatggccgag
     6481 cgtttctacc agtggagcgc ctgacgatgg accgacgtgt cgtgatcacc ggcatcgggg
     6541 tgctcgcccc gggcggcgtc ggtgtgaaga acttctggaa cctgctggag gaggggcgca
     6601 ccgcgacccg gccgatctcg ttcttcgacg ccgggccgtt ccggtcgcgc gtcgccgccg
     6661 agatcgacct ggacgccgag gcgtgcggcc tcacccccca ggagatccgc cggatggacc
     6721 ggggcgcgca gctcgcggtc atcgccgccg gggaggccgt ggccgacagc ggcctcacgc
     6781 ccgacccgga gcggacgggc gtcgtggtcg gcagcgcggt cggcgcgacg acgtcgctgg
     6841 acgaggagta ccgcatcgtc agcgacggcg gacgcctcga cctcgtggac caccgctacg
     6901 ccgtcccgca cctctacgac tacttcgtcc cgagttcgtt ctcccgtgag gtcgcgtggg
     6961 cggtggacgc caccggcccg aacaccgtgg tctccaccgg ctgcacgtcc gggctcgact
     7021 cggtcggcta cgcggtggag ctgatccgcg agggctcggt cgacacgatg gtggcgggcg
     7081 cgtccgacgc gccgatctcc ccgatcaccg tcgcctgctt cgacgcgatc aaggcgacga
     7141 cgccccgcaa cgacgacccc gagcacgcgt cgcgtccgtt cgacgcgagc cgcaacgggt
     7201 tcgtcctcgg cgagggctcg gcgatgttcg tcctggagga gtacgagcag gcgcgggcgc
     7261 gcggcgcgca catctacgcc gagatcgcgg gcttcgccaa ccggtgcaac gcctaccaca
     7321 tgacgggtct gcgccccgac ggccgggaga tggccgaggc gatcaccgcc gcgctgggcg
     7381 aggcccgcct ggacgccacc gcgatcgact acatcaacgc ccacggctcg ggcacccggc
     7441 agaacgaccg gcacgagacg gcggcgttca agcgcagcct cggcgaccac gcctaccgga
     7501 cgccggtcag ctcgatcaag tcgatggtcg ggcactcgct gggcgcgatc gggtccatcg
     7561 agatcgcggc gagcgcgctg gcgatcgagc acaacgtcgt cccgccgacg gtgaacctgc
     7621 acaacccgga ccccgagtgc gatctcgact acgtcccgct gacggcgcgc gagcaccgca
     7681 cggacgtcgt cctgacggtc gggagcggat tcggcggctt ccagagcgcc atggtcctgc
     7741 ggcgggtcgc atgacggcca tcgcgacccg gcgggccgaa gtggtggtga cgggcctcgg
     7801 cgtgaccgcg ccgaacggcc tcggcaccgc cgactactgg gcggcgacgt gcgcgggcgt
     7861 cggcgggatc ggccccgtcc ggcggttcga cgcctcgggc tacccgagcg cgctggccgg
     7921 ggaggtcccc ggcttcgcgg ccgaggagca cctggccagc cgcctgctgc cgcagaccga
     7981 ccacatgacg cggctcgcgc tcgtcacggc ggacttcgcg ctcgcggacg cgggcgtcag
     8041 ccccggcgag tggtcggact acgacctcgg cgtcgtcacg gccagctcgg cgggcggctt
     8101 cgagttcggg cagcgcgagt tgcaagcgct gtggagcaag ggcggccggc acgtcagcgc
     8161 ctaccagtcc ttcgcgtggt tctacgccgt caacaccggc cagatctcga tccggcacag
     8221 catgcgcggg ccgtgcggtg tggtcgtctc cgaccacgcg ggcggtctcg acgcggtcgc
     8281 gcaggcccgc cgccaggtgc ggcgcggcac gagccggctg atgctgtcgg gcggcgtgga
     8341 cggcgcggtg tgctcctggg gctgggtcgc gcagctcgcg agccggcggc tcagcccgga
     8401 cggctaccgg ccgttcgacg cgacggcgtc cggctacgtc cccggcgagg gcggcgcgtt
     8461 cctcgtcctg gaggcggccg agcccgcccg cgagcgcggc gcgcggccct acggccgcat
     8521 cgccggctac ggctccacgt tcgacccgcg cccggacgca cgcgaccgcg aaccgggcct
     8581 gcggcgggcg atcggcctgg cgctggacga cgccgggatc acccccgccg acgtcgacgt
     8641 cgtgttcgcc gacgccgccg gggtccgcga gctggacgcg gccgaggcgg cggcgatcgg
     8701 cgcggtgttc gggcgccacg gcgtcccggt caccgcgccg cagaccatga ccggccggct
     8761 gtacgcgggc gcggcggcgc tgcaggtcgc gtgcgcactg ctcgcgatcc gcgacgggat
     8821 cgtcccgccg acgaccggaa ccgacccgat gcccgaatac gggctcgacc tcgtcgtcgg
     8881 cgaggccagg cggcggcccg tccgcaccgc cctggtcctc gcccgcggct acgacggcaa
     8941 caactcggca ctgatcgtga gagaagaggt gtgacaggtg gctcagctca ccatcgacga
     9001 cctgcggcgc atcctgcggg aggccgcggg cgacgtccag gacatcgacc tcgacggcga
     9061 cgtcatggac ctggagttcg aggcgatcgg ctacgactcc ctggccctgc tggaggccgg
     9121 cagccggatc gagcgcgcgc acggcatcac gctggacgac ggcctcatca gcgaggccgc
     9181 caccccgcgc gacctgctga ccgccgtcaa cgaggtgctc gccgaggcgg acgcggcatg
     9241 aacggcgcgg cgcggacggc gatcgtcacc ggcgcgacga gcggcatcgg cctggcctgc
     9301 gtgcggctgc tcgccgagac gggccaccgg gtgtacctgt gcgcccgcac gcccgagtcg
     9361 gtggccgcga cggtcaagga actcaccggc gagggcctgg acgtggacgg gcgcgcctgc
     9421 gacgtcacgt ccgccgccga catcgccgcg ttcgtcgggg ccgccgtcga gcggtacggc
     9481 ccggtcggcg tgctcgtcaa caacgccggg cgcagcggcg gcggcgtcac ggccgacatc
     9541 gccgacgagc tgtgggacgc ggtcatcgac accaacctca acagcgtgtt ccgcatgacg
     9601 cgcgaggtcc tgaccacggg cgggatgcgc aacctcgacc ggggacggat cgtcaacatc
     9661 gcctcgaccg cgggcaagca gggcgtcgtg ctcggcgcgc cgtactcggc ctccaagcac
     9721 ggcgtcgtcg ggttcaccaa ggcgctcggg aacgagctgg cgccgacggg catcacggtc
     9781 aacgcggtct gccccggcta cgtcgagacg ccgatggcgc agcgggtgcg ggcgggctac
     9841 gccgccgcct gggacacctc cgaggacgag atcctgcgca agttccaggc caagatcccg
     9901 ctcggccggt acagcacgcc cgaggaggtg gccgggctcg tcggctacct cgtcaccgac
     9961 ccggcgtcct cgatcaccgc gcaggcgctc aacgtctgcg gcggtctcgg caacttctga
    10021 cagcggcgtc catccggaag gaagaggcac atgacgacga aaccggccga gcgcgtggtg
    10081 gagcacgaga cgacgatcga ggcggacgcc gacctggtct acgggctgct ggcgcgggcg
    10141 gaggactggc cccacgtgtt cccgccgagc gtctacgtgg agcgcgtccc cgagggaggc
    10201 ggcgcggagc ggatccggat ctgggcgacc gcgaacggcg aggtgcggaa ctggacgtcg
    10261 cggcggctgg tcgaccccgc cgcgcggcgg atcgagttcc gccaggaggt gtcctcgccg
    10321 cccgtcgcgg cgatgggcgg gacgtggacg gtcgagcccg gcccgggcgg gacgtgccgg
    10381 gtggtgctcg gccacgacta ccgcgcggtc gacgacgacc cgcacgacct gctctggatc
    10441 gaccgggccg tcgaccgcaa cagccggtcg gagctggcgt cgctgaagcg gcacgccgag
    10501 ctggcggcgg cggacctggt gttctccttc accgacgccg tccagatcga cggggccgcc
    10561 gcggacgcgt tcgcgttcgt caacgaggcg gcgctgtggc ccgagcggct gccgcacgtc
    10621 gcgcgggcgg agctgaccga gaccacgccc ggcctccaga cgctgaagat ggacacgcgg
    10681 gccaaggacg ggtcgacgca cacgaccgag tccgtccggg tctgcttccc gcaccacaag
    10741 atcgtctaca agcagacgac cgtccccgcg ctcatggccg cccacaccgg gacgtggctg
    10801 ttccgggacg acggcgcggg ctccaccgcc agctccgagc acaccgtcgt gctcaacccg
    10861 gacacggtgg agaaggtcct cggcgcgggc gcgaccgtcg ccgacgcccg cgcgtacgtc
    10921 cagggcgcgc tgagcgccaa cagcctggcc acgctcggcc acgcccggac gttcgccgag
    10981 agccgctgac atgggcaccg acaccggcgc cgacgtgatc gtcgtcggcg cgggacccgt
    11041 cgggctgctg ctggcgggcg ggctgcgggc cgccggggtg cgcgcggtcg tcctggagcg
    11101 gcggaccgcg ccgatggacg agtcgcgcgc ctcgacactc aacgcccgca ccatggaggt
    11161 cctcgccgag ctgggcgcgc tgtcccggct cggcgggctc ccccgcgagc cgcgcggcca
    11221 cttcgggggg ctcccgctcg acctcggcgc ggtcggcggg acgccctacc ccgggcagtg
    11281 gaagatcccg cagaccgtgc tggaggccaa gctcggcgcc tggctcgccg aactcggcgt
    11341 gcccgtccgg cgcggcgcgg cggcggaggc gctggagcag gacgccgccg gcgtcaccgt
    11401 gaccgcgtcg gacgggaccg ccgtgcgcgg ctcctacgtc gtgggctgcg acggcgtcgg
    11461 cagcaccgtc cgcgcgctgg ccggaatcgc gttccccggc cgcgcggcgg gacgggaact
    11521 gctccgggcc gacgtgcgcg gcgtcgacgt ccgcgaccgg cgcttcgagc gcctgccggc
    11581 gggcctcgcc atcgccgcga cgcgcgacgg cgtcacccgc ctgatgacgc acgcgttcgg
    11641 caccccggcc cgcgaccgcg gcgggccgcc cgatttcgcc gagttcgccg cgacctggaa
    11701 gcgggtcacc ggcgaggacg tcagcggcgg cgagccgctg tggtgcgacg cgttcggcga
    11761 cgccagccgg ctcgccgagc gctaccgcgc gggccgggtg ctgctggcgg gcgacgccgc
    11821 ccacgagcag atgccggtcg gcgggcaggc gctcaacctc gggctccagg acgccgccgc
    11881 gctcgtcccc cgcctcgcgg cggccgtggc gggcgtgtcc ggcgacgcgc tcctggacgc
    11941 ctacgccgcc ggacgccatg ccgtcggcgc acgcgtccag cgcgacgtcg aggcgcagac
    12001 cctgctgctg ctcggcggac cggaggtcac gccggtgcgg acggtgctcg ccgagctgct
    12061 ggagcgcccg cccgtgcggg agttcctcgc cgccggggtc agcggggtgg cggaaggcgt
    12121 gcgatgagcg cccacgccgc cgacatgcgg atcgccgtca tgctggcggg catcgcgctc
    12181 gtcctgctgg cgggcctggt gttcggacgg atcgcgcggg cggtgcggca gcccgccgtc
    12241 gtcggggaac tggtcgcggg catcgcgctc gggccgagcc tgctcggcgc gctgcccggc
    12301 gacccgtccc accggatctt ccccgacgac gtgcgcccgc tgctgtcggc cgtcgcgcag
    12361 gtcgggctcg tcctgttcat gttcgcggtg ggctgggagt tcgagaagcg gctcatccgc
    12421 ggcaacgtcg gcgcggcgat cggcgtgtcg gtgtcgtcgg ccgtgctggc gttcgggctc
    12481 ggcgtcggcg cggcggcggt cctgtacgcg cggcacgaca ccgtcgcggg caagcacgtc
    12541 gggttcctgc cgttcgccct gttcctcggg atcgcgctgt cggtcaccgc gttccccgtc
    12601 ctcgcgcgga tgctcgccga gagcagcctc gccgacaccc ggatcggcgc ggtcgcgctg
    12661 gccggggcgg cgatcgacga cgtcctcgcg tggttcctgc tggcgtacgt gtccgcgctg
    12721 gtcagcgcgg acggcagcgg ttcgggcctc gcccggatcg ccgtgctgtt cgccctctac
    12781 ctcgccgtca tggccgccgt cgtgcggccc cttctcagcc ggatcgtctg gcgctgggcg
    12841 gccaccgagc ggtggcccgc cctgctgacc ctgctgtgcg cgggcgtctt cctgtcgtcc
    12901 tgggtgacga cctggatcgg cgtccacgcc atcttcggcg cgttcctgtt cggcttcgtc
    12961 atgccgcgcg aaccggcccg cgtcctcgcc gagcacgtcc ggcggcccct ggacgacgtg
    13021 atcctgctcc tgctccccgt cttcttcatc gtcacgggcc tcaacgtcga cgtcggcgcg
    13081 ctggacggcc ccggactgct cgaactcgcc ctcgtcctgg tgtgcgcgtg cgccgggaag
    13141 atcggcggcg cgctggtgcc ggcgcggctg gccggcctcg gctggcggga cgcgacgacg
    13201 ctcggcctgc tgatgaacac gcgcggcctc accgaactga tcatcctgaa cgccgcgatg
    13261 agcctcggcg tcctcgacgg ccgcatgttc accgtcctcg tgctgatggc cgtgctcacc
    13321 accgcgatga ccgggccgtt cctgccccgg cgcgcgggcg cggcggaccc gccggtgctg
    13381 gtacccgccc ggccgacgaa aggagctgga cacccgtgac caccgcacga ccgtccgacg
    13441 ggctcgtgga cgccgccgcg ctgcgccgca cctgcggcct gttcgccacc ggcgtcaccg
    13501 tcatcaccag cgcgcacggc ggcatgaccg ccggcaccac cgtcaactcg ttcacctcgg
    13561 tctcgctcga cccgccgctc gtgctgttct gcctgcaccg ggagtcccgg ctgcacgaga
    13621 tcatcaccgg atcgcgggcg ttcgccgtca acctgctgca cgccgagcag ggcacgctcg
    13681 cccacgcgtt cgcgcggcgc agcaccgccg tgctggacga ggtggaccac cggcggaccc
    13741 cgtcggggac cccggtcttc gccgagtccc tggcctacct ggactgccgc ctggccgccg
    13801 agtacggcgg cggcgaccac tcgatcctcg tcggggaggt cgtggacctc gcgatccacg
    13861 acgccggcag cgacccgctg gtgttcttcg gcggctcgct gcacagcctg gacaacccgc
    13921 tgcggcgcag ggccgggctc cgatgacgcc gatgcgccgg gtcctcatcg ccaaccgggg
    13981 cgagatcgcg gtccggatcg cgcgggcgtg ccgcgacgcg ggcctggtct cgatcgccgt
    14041 gtacgccgag caggacgtcg acgcgctgca cgtccgggcc gccgacgagg cgtacgcgct
    14101 cggcgggcgc agccccgccg agacctacct cgacatcgcc gggctcctcg ccgtggcggc
    14161 gcgggcggac gccgacgccg tccatccggg ctacgggttc ctcgccgaga acgccgactt
    14221 cgcgacggcg gtcgcggcgg ccgggctgac gtggatcggc ccgccgcccg cggccatcgc
    14281 cgcgctcggc gacaaggtcg cggcgcggga catcgcgcgc cgcgtcaacg ccccgctggc
    14341 cccgggcacc gacggcccgg tcgccgacgc cgaagaggtg ctggagttcg cgcggcggca
    14401 cggcctgccg gtcgcgctga aggccgcgtt cggcggcggc gggcgcggcc tgcgggtcgc
    14461 gcggacgctc gcggagatcc cggcggcgtt cgaggccgcg acgcgcgagg ccgtcgcggc
    14521 gttcggccgg ggcgagtgct tcgtcgagcg ctacctggag aactgccggc acgtcgagac
    14581 gcagtgcctg gccgaccggc acggcaacgt catggtcgtc tccacccgcg actgcacgct
    14641 ccagcgccgc caccagaagc tcgtggagga ggcgcccgcg cccttcctca ccgacgagca
    14701 gaccggccag ctcgtgtccg cgtcgcgggc ggtgctgcgc gaggcgggct acgtcggcgc
    14761 cgggacgtgc gagttcctgc tcgccccgga cgggacgatc gcgttcctgg aggtcaacac
    14821 gcggctccag gtcgagcacc cggtgaccga ggaggtgacc gggatcgacc tcgtccgcga
    14881 gatgttccgg atcgccgacg gcggcgtgct ggaaccgtcc gacccgcccg tgcgcggcca
    14941 cgcgatcgag ttccggctga acgccgagga cgccgggcgc gggttcctgc ccgccgccgg
    15001 gacgctgacc cggttccggc cgccgtcggg gccgggcgtg cggatggacg cgggctacgt
    15061 cgagggcgcg gccgtcccgg cggagttcga ctcgctcatc ggcaagctca tcgtgaccgg
    15121 gcggacgcgg cgggaggcga tcgagcggtc ccggcgcgcg ctggccgagc tggaggtcgc
    15181 gggcatcccg acggtcgtgc cgttccaccg ggcgctgctg gcggacgagg cgttcaccgg
    15241 ggagccgttc accgtccaca cccgctggat cgagacggag ttctccgggg ccgtcccgcc
    15301 gcacgcggac gcgccggacg ccccggccga cgacgccggg caccgtcggg tgacggtcga
    15361 ggtcggcggg cggcggctgg aggtcgtgct gcgcgacgcg ctcggcgcgg cgctcgtgcc
    15421 ggcggcgggg cgccccgccc cggcccgcgc cgcgcgccgt gccgggcccg ccggcgcggg
    15481 cggcgacgcg ctcgtcagcc cgatgcaggg gacggtcgtg aaggtgctgg tcgccgacgg
    15541 cgccccggtc gcggccgggg acaccgtgct cgtcctggag gcgatgaaga tggagcaggg
    15601 gctgaccgcg caccggtccg gcaccgtccg ggacctgtcc gcgcaggccg gggccacggt
    15661 ggcggccggg gccgcggtgt gccggatcgt cgatccgccc gcgccggagg cgtgagcgcc
    15721 ggggcggatc gtccccgccc ggccgggacg tgccgaattc gttgacaggg ccaacgggcc
    15781 gcgctctact tatcctgaag aggaatcccc ttccgattaa gaggagttcg gctcgtggcc
    15841 agtcccgaaa ccccggcgct caaaccgccc agaaccagcg cacccggccg cgtctacaag
    15901 ccggggatcg tgctcgcgtt catctgcgtc gcccagttca tggtcttcct cgacgtgacc
    15961 gtcgtgaatg tcgcgctcgc tcacattcag aagagcctcg acatggcgga gacggacctg
    16021 cagtacatcg tcaccgccta tggcacggtc ctcggcggct tcctgctcct cggcggccgg
    16081 ctcgccgacg tggtcggccg ccgccggatg ctccagatcg gcctgttcct gttcgcggcc
    16141 agctcgctcg tcgccggggt ctcccagagc ccgggcgtcc tcatcggcgc gcgcggcttc
    16201 cagggcctcg gctcggcgct catcgcgccc gccgcgctca gcatcctcac cagcaccttc
    16261 aaggagggcc ccgagcgcac ccgcgcactc ggcatctggg gcgccctgac cgggctcgcg
    16321 tccgtcgcgg gcgtcctgct cggcgggatc ctcacccagg ggcccggctg gcgctggatc
    16381 ttcttcatca acgtcccgat cggcatcatc gcggtgctgc tcgccccgct gctcgccccc
    16441 gagagccgcg acaccgagcg gcgtcaccgc atcgacgtga ccggcgcgat cctgctcacc
    16501 accgggctgc tcctgctcat ctacacgctc aacgagaccg tcaaccgcgg ctggggcgac
    16561 ggccggacga tcggcggcct cgccggcgcg gcggtcctgc tcgccgcgtt cctcatcgtg
    16621 gagggccgca cgaaggaacc gctgatgccg ctcggcatct tccgcaacac cgcgatgcgg
    16681 acggcgaacc tcgcgaccgt cctgctgttc gggtcgacgg tcacgctgtt cttcttcgcc
    16741 agcctgttca tgcaggtcgt cctcggctac tcggcgctca agacgggcct ggcctacgtg
    16801 ccgctcgcgc tcgtcgtcgc gatcgccgcg ggcatcgcct cgacgctcac caccaagatc
    16861 gcggcgaaac cggtcatgct caccggcatg ttcctcagcg ccgccgggct ggtcatgctg
    16921 gcccggctgc ccaaggacgg cagctatctc acgcacgtgc tgcccgcgtt catcgtcgcg
    16981 ggcgccgggc tcggtgcgtc cttcgtgacg ctccaggtcg cggcgttcat cggcgtccgc
    17041 cagcacgagg cgggcctggc cgccgggctg atcaacacca gccaggaggg cggcggcgcg
    17101 ctcggcgtcg cggtggtcgc gacggccgcg ttcgccaaga tcaaggatct gcgcgacgcg
    17161 gcggcgggca acgccgaccg catcaaggac gcccaggcgt ccggcttcca cgaggcgttc
    17221 gtcatcggcg ccgggttcgc cgtcaccgcg ctggtcctcg cgctggtgct gctgcccatg
    17281 atgcgcgcgt ccgaacgtcc cgacaccgtc atcggctgac cgtcccgacc cggagagaca
    17341 gcatgaccaa catcgtcaag ttgaccagac gggccgagac gttcgtgagc gacgcgcagg
    17401 tcggcgtcct caccacgctc cgtcccgacg ggacgccgca cagcgtgccg gtctgcttca
    17461 ccttcgaccc cggcgccggg ctcgtccgcg tgctcacccg ggccgcgtcg cgcaaggcgc
    17521 gcaacgtgat cgagagcccc ggcggacgcg cgacgatctg ccaggtcgcc gggccgaagt
    17581 tcctgtccat ggaggggacg gccgaggtgt ccggcgagcg ggcgcgcgtg gaggaggggg
    17641 cgcgctggta cgccaagcgc tacgcctacg cgccgccgag cccgccggac cgcgtcgtca
    17701 tcgagatcgc cgtcgaccgc gtgctcgacg ggatcagcta gaccccgccg gcggccgccc
    17761 gtccatccac tggacgcgga acgacagccg ggtgaggcgc cagcccgcgt ccgtgcggac
    17821 ggcgtccccg tcgaccagcg ttccggtccg gaagaactcg ggcggcccgc catcgcgggt
    17881 ggcgtggtgg acgtgcgtcg acgtcagatt cgcccgcagg ccggcgcggt cgccggccac
    17941 ctggacggcc ggcggcgacc cgaggtgctg ggtcgccgcg aagttcccga gcgcgtcgcg
    18001 gtggtagccg gccatcccgg cgaggccgcg gtgcgcgctc atcgggaact ccacgaccgc
    18061 gtcggcggtg aacaggccgc cggcccagtc gtcgtccagg gggtcggcgt ccaggccgat
    18121 caggtagcgg gcgagcagtt cggcgacgtc cgtccggtcg atgttcgtca ggtcgctgtg
    18181 catctgcttc atgcgccgag catgaaccgc gcccgcccgc ccgcaccacc gctcccagga
    18241 agacctgaca aacctcatga acggctgacc ctcccccctg aaggagagat cgtggacgac
    18301 gagaaccccc gtgtcgtcat cgtcggtgcg ggaccgaccg gactcatgct cgccggcgag
    18361 ctggcgctcg ccggaatccc cgccctgctc gtggaccggc tcgccgagcc gatgcagcag
    18421 tcgcgcgcgc tcggcttctc cgcccgcacc atcgaggagt tcgaccagcg cggactcctg
    18481 ccccgcttcg gaaccctgga gactcttccg ttcgggcact tcggcgggtt cttcatggac
    18541 ttcacggccg tcgacaacgg gtcctacggc gcccgcggcg tgcaccaggc ccggaccgag
    18601 gccgtgctga ccgcgtggat cggcgagctg ggcgtgaaga tccaccgcga gcacgaggtg
    18661 accggcctcg ggaccgacgc cgacggcgtg accgtccgga tgcgcacgcc ggacggcgag
    18721 cgcgaggtcc gcgccgagta cgtcgtgggc tgcgacggcg cccgcagcac ggtccgcaac
    18781 ctcgcgggca tcggtttccc cggcaccgag gcgaccgtcg aggtgtggct ggcggacgtg
    18841 tccggacccg agctgcgtcc ccgcttcgcc ggcgagcgcg tcgacggcgg catggtgatg
    18901 gtgctgccgc tcggcgacgg cgtgaaccgc atcgtcgcct acgagcgcgc gatggccccg
    18961 accggccgga cgaccccgcc gtcgttcacc gaggtcgcgg accgcttcga gcggctgacc
    19021 ggcggcgagc gcgtccacga cggcgaggcg ctgtgggtga gctggttcac cgacgccagc
    19081 cgccaggccg agcgctaccg cgacgggcgg gtgttcgtcg cgggcgacgc ggcgcacgtc
    19141 cacctgccga tcggcgcgca gggcatgagc gccggcgtgc aggacgcggt gaacctcggc
    19201 tggaagctcg ccgccgtcct gaagggcgac gcgcccgacg ccctgctcga cacctaccac
    19261 gccgagcggc acccggtcgg cgcgcggatc gtcgcgaaca cgctcgtgca gcggttcctc
    19321 tacctcgacg gcgacgcgat gcagcccctg cgcgacgtct tcggcgagct gatgttctac
    19381 cccgacgtgc agcggcacct gatcggcatg gtcacgggcc tggacgtccg ctacgacgtc
    19441 ggccccgggt cgcacccgct gctcggccgc cggctgccga acgaggaact cgtcctgccc
    19501 gaccggaaga ccaccaacta cgacctcctc cacaacggcc gcggcgtgct gctgatcctg
    19561 gacgactccg ccggcctgtc cgcccgcgcc gaaccctggg cggaccggct ggacatcatc
    19621 cgggccgacc agcacgactg caaggccccg ctggacgcgc tgctcgtccg tcccgacgga
    19681 tacgtcgcct ggctgacgcc gggaaccgac gacggcgccg acctcacgac cgcactgacc
    19741 cgctggttcg gtcccgaccc ctcatccacc tcaacgagcg aatcatcaac gagcgaaagc
    19801 gagtcgtaga tgcccacgtt cgccgcggac ggcaagtacc tgaccgtcct caacctgttc
    19861 accaccgaca ccgacgagaa gcagggcaag ctgatcggcg cgatgcgcga cgtcgtcgac
    19921 aacgccgcct atccgggctg gatctccagc accgtccaca gcggcaagga gagcccgggg
    19981 acggccaact tcatccagtg gcgcagcggc gaggacctgg aggcccgcta cgccggcgag
    20041 gagttcaagc accgcaccct cccgctgttc cgggagatca ccacgtccat caagctgctc
    20101 cagaccgacg tcgtctacac ccagcgggcg ccggagcaga cggagatcga gatcggcccg
    20161 gaccgcgacg acttcaccgt catccaggtc atcggcgcga cggaaggggg cctggacgac
    20221 ctggtcgagg cgctcggcgc gggccacgcg tggctgcggg acgtccccgg ctaccgctcg
    20281 cacaccgtcc tgcggggccg cgcggcacgc gggctcgacg gcccgttcgc cgtcgtttac
    20341 tcccagtggg acgacgaggc ttcgttcgcg gcgttccgtg ccgtgagcgc ggacgagcag
    20401 tcggccgagc gccgcgccgc gaccgaacgg gtcgaggcgt cgtccacttt ccatgactgg
    20461 aatacctacc aggtggtcca cacccggtcg gcggcggcgc cgaccggatc ggcggtctag
    20521 aaagaacgcg gcgggcgggg cgcgatgccc cgcccgccgc gtgtccggaa gtgggcagaa
    20581 taagaaaacc gaaaccctct catcttgacc tgaagaatat ctaaaaccgc cagctcatgc
    20641 gctatagata gcgaatgaac ggaccagtcc aattaccctc agtcagcttg aagccgacaa
    20701 cacacgaacg cataatacga gtgttcgcga ccccaaattc actgcgagaa tctgctggtt
    20761 ccacgaccca cactggggct gaggatgcgc gtgctcgtcg ttgaacccga ctgccggacg
    20821 gcggaacatc tcgtccactg gctcgtccgg cacggctacg aggtcgacct cgtcgacacc
    20881 ggccgccgga cgctggaggt cgcggcgacc gcggacctcg tcctgctgga cctcggcctc
    20941 cccgacctcg acgggatcga ggtctgccgt tccctgcgcg accgcaccga cgccccgctg
    21001 atcacgttca ccggggccgg cacggagctg gaccgggtgc tgagcctgca ggccggcgcc
    21061 gacgactgca tggtgaagcc gtacgggctg cgggaactcg tggccaggat ggaggcggtg
    21121 atgcgccggg tgctgccgca cggccggggc gtccgcgggc tgatcgcgca cgggacgctg
    21181 gagatcgacc tggaccggcg gcaggtgcgg gtccggggcg gcgacgtgga gctgacgcgc
    21241 aaggagttcg agctgctgcg catcctcgcc tcccggcccg agtcggtgat cacccgcagg
    21301 gagctgatgt cgcgcgtctg ggaggacgac tgggccgcct cgacccggac gatcgacacg
    21361 cacgtcagct ccctgcggca caagctcggc gacgccgagt ggatcgtcac cgtgcgcggg
    21421 gtggggtacc ggctcggctc agggtcgctg accgatgcgg cggcgcaggt ccagccactg
    21481 gtgtga
//
