BGC0002369: maduralactomycin A biosynthetic gene cluster from Actinomadura rubteroloni
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Location: 91,309 - 112,794 nt. (total: 21,486 nt).
This entry is originally from NCBI GenBank MTBP01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002369
Short description maduralactomycin A biosynthetic gene cluster from Actinomadura rubteroloni
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MTBP01000002.1
91309 - 112794
via
Compounds
  • maduralactomycin A
  • maduralactomycin B
  • actinospirol A
  • actinospirol B
Species Actinomadura rubteroloni [taxonomy]
References
Chemical products information
maduralactomycin A Evidence:
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Chemical database entries
NPAtlas
PubCHEM
maduralactomycin B Evidence:
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Chemical database entries
NPAtlas
PubCHEM
actinospirol A Evidence:
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Chemical database entries
NPAtlas
PubCHEM
actinospirol B Evidence:
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Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTM25_23770
  • POM23755.1
 91309 - 92976 (-) N-methyltryptophan oxidase
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    • BTM25_23780
    • POM23756.1
    • acrR_1
    		 93177 - 93800 (+) HTH-type transcriptional regulator AcrR
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      • BTM25_23790
      • POM23757.1
      		 93797 - 93988 (-) hypothetical protein
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        • BTM25_23800
        • POM23758.1
        		 94196 - 95749 (+) Methylmalonyl-CoA carboxyltransferase 12S subunit
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          • BTM25_23810
          • POM23759.1
          		 95746 - 95919 (+) hypothetical protein
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            • BTM25_23820
            • POM23760.1
            • pcpB_3
            		 96001 - 97476 (+) Pentachlorophenol 4-monooxygenase
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              • BTM25_23830
              • POM23761.1
              • tcmI
              		 97489 - 97812 (+) Tetracenomycin polyketide synthesis protein TcmI
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                • BTM25_23840
                • POM23762.1
                		 97815 - 99062 (+) Actinorhodin polyketide putative beta-ketoacyl synthase 1
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                  • BTM25_23850
                  • POM23763.1
                  		 99059 - 100282 (+) Actinorhodin polyketide putative beta-ketoacyl synthase 2
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                    • BTM25_23860
                    • POM23764.1
                    		 100286 - 100549 (+) Actinorhodin polyketide synthase acyl carrier protein
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                      • BTM25_23870
                      • POM23765.1
                      • actIII
                      		 100546 - 101328 (+) putative ketoacyl reductase
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                        • BTM25_23880
                        • POM23766.1
                        		 101359 - 102297 (+) putative polyketide cyclase
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                          • BTM25_23890
                          • POM23767.1
                          • pcpB_4
                          		 102299 - 103435 (+) Pentachlorophenol 4-monooxygenase
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                            • BTM25_23900
                            • POM23768.1
                            • nhaS3_1
                            		 103432 - 104727 (+) High-affinity Na(+)/H(+) antiporter NhaS3
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                              • BTM25_23910
                              • POM23769.1
                              • ntaB
                              		 104724 - 105254 (+) FMN reductase (NADH) NtaB
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                                • BTM25_23920
                                • POM23770.1
                                • accC_1
                                		 105251 - 107023 (+) Biotin carboxylase
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                                  • BTM25_23930
                                  • POM23771.1
                                  • efpA_3
                                  		 107143 - 108627 (+) putative MFS-type transporter EfpA
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                                    • BTM25_23940
                                    • POM23772.1
                                    		 108651 - 109049 (+) Pyridoxamine 5'-phosphate oxidase
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                                      • BTM25_23950
                                      • POM23773.1
                                      		 109042 - 109500 (-) hypothetical protein
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                                        • BTM25_23960
                                        • POM23774.1
                                        • pcpB_5
                                        		 109600 - 111117 (+) Pentachlorophenol 4-monooxygenase
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                                          • BTM25_23970
                                          • POM23775.1
                                          		 111118 - 111828 (+) Antibiotic biosynthesis monooxygenase
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                                            • BTM25_23980
                                            • POM23776.1
                                            • srrA
                                            		 112099 - 112794 (+) Transcriptional regulatory protein SrrA
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                                              Biosynthesis information
                                              Annotation changelog

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Entry added
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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