BGC0002376: bombyxamycin A biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 113,079 nt. (total: 113,079 nt).
This entry is originally from NCBI GenBank MK433001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002376
Short description bombyxamycin A biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MK433001.1
1 - 113079
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • bombyxamycin A
  • bombyxamycin B
Species Streptomyces sp. [taxonomy]
References
Chemical products information
bombyxamycin A Evidence: Mass spectrometry [1], NMR [1], Chemical derivatisation [1]
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C27H33N1O3
Chemical database entries
NPAtlas
bombyxamycin B Evidence: Mass spectrometry [1], NMR [1]
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C27H31N1O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QBL56159.1
  • bomA
 1 - 1566 (-) monooxygenase
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    • QBL56160.1
    		 1804 - 2007 (+) hypothetical protein
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      • QBL56161.1
      		 2088 - 3737 (+) long-chain-fatty-acid--CoA ligase
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        • QBL56162.1
        		 3734 - 4576 (+) 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate synthase
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          • QBL56163.1
          		 4548 - 5666 (+) 3-dehydroquinate synthase II family protein
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            • QBL56164.1
            • bomB
            		 5663 - 6901 (+) monooxygenase
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              • QBL56165.1
              • bomR1
              		 6915 - 7523 (-) LuxR family transcriptional regulator
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                • QBL56166.1
                		 7886 - 9316 (-) hypothetical protein
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                  • QBL56167.1
                  		 9392 - 11512 (+) ATP-binding protein
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                    • QBL56168.1
                    		 11505 - 13808 (+) hypothetical protein
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                      • QBL56169.1
                      		 13870 - 14544 (+) RES domain-containing protein
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                        • QBL56170.1
                        		 14597 - 14854 (-) hypothetical protein
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                          • QBL56171.1
                          • bomR2
                          		 15016 - 15405 (+) XRE family transcriptional regulator
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                            • QBL56172.1
                            		 16068 - 17261 (+) hypothetical protein
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                              • QBL56173.1
                              • bomR3
                              		 17263 - 19401 (-) SARP family transcriptional regulator
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                                • QBL56174.1
                                • bomR4
                                		 19920 - 22592 (+) LuxR family transcriptional regulator
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                                  • QBL56175.1
                                  		 22681 - 23529 (+) metallophosphoesterase
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                                    • QBL56176.1
                                    		 23526 - 24296 (+) 4'-phosphopantetheinyl transferase superfamily protein
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                                      • QBL56177.1
                                      • bomR5
                                      		 24628 - 25533 (+) transcriptional regulator
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                                        • QBL56178.1
                                        • bomR6
                                        		 25817 - 26506 (-) putative transcriptional regulator for fatty acid degradation FadQ
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                                          • QBL56179.1
                                          • bomR7
                                          		 26775 - 27218 (-) cold-shock protein
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                                            • QBL56180.1
                                            • bomC
                                            		 27381 - 28313 (-) L-amino acid amidase
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                                              • QBL56181.1
                                              • bomP1
                                              		 28412 - 39628 (-) PKS
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                                                • QBL56182.1
                                                • bomP2
                                                		 39637 - 50370 (-) PKS
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                                                  • QBL56183.1
                                                  • bomP3
                                                  		 50436 - 55307 (-) PKS
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                                                    • QBL56184.1
                                                    • bomP4
                                                    		 55462 - 66063 (-) PKS
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                                                      • QBL56185.1
                                                      • bomD
                                                      		 66620 - 66856 (+) acyl carrier protein
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                                                        • QBL56186.1
                                                        		 66868 - 67770 (+) transposase
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                                                          • QBL56187.1
                                                          • bomE
                                                          		 67739 - 69289 (+) long-chain-fatty-acid-CoA ligase
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                                                            • QBL56188.1
                                                            		 69423 - 71018 (+) transporter
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                                                              • QBL56189.1
                                                              • bomR8
                                                              		 71129 - 71890 (-) TetR family transcriptional regulator
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                                                                • QBL56190.1
                                                                • bomF
                                                                		 72023 - 73225 (-) FAD-dependent oxidoreductase
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                                                                  • QBL56191.1
                                                                  • bomP5
                                                                  		 73301 - 78514 (-) PKS
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                                                                    • QBL56210.1
                                                                    • bomP6
                                                                    		 78522 - 94829 (-) PKS
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                                                                      • QBL56192.1
                                                                      • bomG
                                                                      		 94940 - 96301 (-) methylaspartate mutase
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                                                                        • QBL56193.1
                                                                        • bomH
                                                                        		 96298 - 96798 (-) glutamate mutase sigma subunit 2
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                                                                          • QBL56194.1
                                                                          • bomI
                                                                          		 96795 - 98057 (-) diaminopimelate decarboxylase
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                                                                            • QBL56195.1
                                                                            • bomJ
                                                                            		 98054 - 99589 (-) long-chain-fatty-acid-CoA ligase
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                                                                              • QBL56196.1
                                                                              		 99749 - 99943 (-) ferredoxin
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                                                                                • QBL56197.1
                                                                                • bomK
                                                                                		 99955 - 101184 (-) cytochrome P450 hydroxylase
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                                                                                  • QBL56198.1
                                                                                  • bomL
                                                                                  		 101234 - 102097 (-) sugar phosphate isomerase/epimerase
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                                                                                    • QBL56199.1
                                                                                    • bomM
                                                                                    		 102215 - 103162 (-) ACP S-malonyltransferase
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                                                                                      • QBL56200.1
                                                                                      		 103517 - 105127 (+) acyl-CoA carboxylase subunit beta
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                                                                                        • QBL56201.1
                                                                                        		 105145 - 105378 (+) hypothetical protein
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                                                                                          • QBL56202.1
                                                                                          • bomR9
                                                                                          		 105476 - 106240 (+) type II thioesterase
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                                                                                            • QBL56203.1
                                                                                            		 106790 - 107059 (+) hypothetical protein
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                                                                                              • QBL56204.1
                                                                                              		 107468 - 108985 (+) histidine kinase
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                                                                                                • QBL56205.1
                                                                                                		 108982 - 109425 (+) roadblock LC7 family protein
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                                                                                                  • QBL56206.1
                                                                                                  		 109422 - 109784 (+) hypothetical protein
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                                                                                                    • QBL56207.1
                                                                                                    		 109762 - 110394 (+) ATP-binding protein
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                                                                                                      • QBL56208.1
                                                                                                      • bomN
                                                                                                      		 110391 - 111740 (+) cytochrome P450 hydroxylase
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                                                                                                        • QBL56209.1
                                                                                                        • bomO
                                                                                                        		 111832 - 113079 (+) cytochrome P450 hydroxylase
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                                                                                                          Biosynthesis information

                                                                                                          No biosynthesis information available for this record.

                                                                                                          Annotation changelog

                                                                                                          Entry version: 2

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2024-04-23
                                                                                                          MIBiG v4 annotathon
                                                                                                          • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                          Entry version: 1

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2022-09-15
                                                                                                          Entry added
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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