BGC0002378 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002378 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,arylpolyene	1	41,818	coprisamide C/coprisamide D	NRPS:Type I	100%

BGC0002378 - Region 1 - NRPS,arylpolyene

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Location: 1 - 41,818 nt. (total: 41,818 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
arylpolyene: (APE_KS1 or APE_KS2)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,819
Label		BGC0002378

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002510	1.02	Polyketide	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0002378	0.93	NRP	coprisamide C, coprisamide D	Streptomyces sp.
BGC0002474	0.59	NRP	agrobactin	Agrobacterium tumefaciens
BGC0001444	0.57	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0000836	0.54	Other	APE Ec	Escherichia coli CFT073
BGC0000867	0.51	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0002711	0.51	Polyketide	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000243	0.50	Polyketide	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000839	0.49	Other	flexirubin	Chitinophaga pinensis DSM 2588
BGC0002076	0.49	Other	4,5-didehydroacaterin, acaterin	Pseudomonas jessenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002378	0.85	NRP	coprisamide C, coprisamide D	Streptomyces sp.
BGC0002510	0.80	Polyketide	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000426	0.73	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.73	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.70	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001185	0.69	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000417	0.68	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000401	0.68	NRP	paenibactin	Paenibacillus elgii B69
BGC0002474	0.67	NRP	agrobactin	Agrobacterium tumefaciens
BGC0002437	0.67	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 41818:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Ala - D-Ser) + (D-Leu - Val - X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 13870 - 41818:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Leu - Val - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

copA

Search NORINE for peptide: strict or relaxed

AMP-binding (478..884): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVAIVYK
Nearest Stachelhaus code(s):: Ala DVFSVAIVYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2001..2408): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLVDK
Nearest Stachelhaus code(s):: Ser DVWHISLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

copB

Search NORINE for peptide: strict or relaxed

AMP-binding (465..859): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALLVGAIAK
Nearest Stachelhaus code(s):: Leu DALLVGAIAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2003..2402): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYWWGGTFK
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3064..3472): X

nrpys: Dpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIWEMTADDK
Nearest Stachelhaus code(s):: Dpr DIWEMTADDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4135..4542): X

nrpys: bMe-Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKLGMVNK
Nearest Stachelhaus code(s):: bMe-Asp DLTKLGMVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)