BGC0002378: coprisamide C biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 41,818 nt. (total: 41,818 nt).
This entry is originally from NCBI GenBank MT813120.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002378
Short description coprisamide C biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT813120.1
1 - 41818
via
Compounds
  • coprisamide C
  • coprisamide D
Species Streptomyces sp. [taxonomy]
References
Chemical products information
coprisamide C Evidence:
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Chemical database entries
NPAtlas
coprisamide D Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QRG35011.1
 1 - 951 (+) ATP-binding cassette domain-containing protein
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    • QRG35012.1
    		 964 - 1752 (+) ABC transporter permease
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      • QRG35013.1
      • copA
      		 2032 - 11271 (+) NRPS
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        • QRG35014.1
        • copB
        		 11268 - 26258 (+) NRPS
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          • QRG35015.1
          		 26290 - 26508 (+) MbtH family protein
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            • QRG35016.1
            • copC
            		 26583 - 26840 (+) acyl carrier protein
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              • QRG35017.1
              		 26892 - 27419 (+) DUF3995 domain-containing protein
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                • QRG35018.1
                • copD
                		 27419 - 28423 (+) 2,3-diaminopropionate biosynthesis protein SbnA
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                  • QRG35019.1
                  • copE
                  		 28425 - 29432 (+) 2,3-diaminopropionate biosynthesis protein SbnB
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                    • QRG35020.1
                    • copF
                    		 29516 - 30256 (+) 3-oxoacyl-[acyl-carrier-protein] reductase
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                      • QRG35021.1
                      • copG
                      		 30253 - 30696 (+) hypothetical protein
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                        • QRG35022.1
                        • copH
                        		 30683 - 31165 (+) beta-hydroxyacyl-ACP dehydratase
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                          • QRG35023.1
                          • copI
                          		 31238 - 31495 (+) acyl carrier protein
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                            • QRG35024.1
                            • copJ
                            		 31501 - 32709 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                              • QRG35025.1
                              • copK
                              		 32706 - 33896 (+) hypothetical protein
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                                • QRG35026.1
                                • copL
                                		 33871 - 35007 (+) hypothetical protein
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                                  • QRG35027.1
                                  • copM
                                  		 35004 - 35993 (+) beta-ketoacyl synthase
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                                    • QRG35028.1
                                    		 35995 - 37851 (+) alpha/beta fold hydrolase
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                                      • QRG35029.1
                                      • copN
                                      		 37848 - 38567 (+) disulfide bond formation protein DsbA
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                                        • QRG35030.1
                                        • copO
                                        		 38584 - 39057 (+) hypothetical protein
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                                          • QRG35031.1
                                          • copP
                                          		 39054 - 40385 (+) methylaspartate mutase
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                                            • QRG35032.1
                                            		 40339 - 40947 (+) hypothetical protein
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                                              • QRG35033.1
                                              		 41060 - 41818 (+) thioesterase
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                                                Biosynthesis information

                                                Biosynthetic modules

                                                Name
                                                Unk01
                                                Type
                                                nrps-type1
                                                Genes
                                                copA
                                                Substrates
                                                alanine (evidence: Structure-based inference [2])
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Name
                                                Unk02
                                                Type
                                                nrps-type1
                                                Genes
                                                copA
                                                Substrates
                                                serine (evidence: Structure-based inference [2])
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Name
                                                Unk03
                                                Type
                                                nrps-type1
                                                Genes
                                                copB
                                                Substrates
                                                leucine (evidence: Structure-based inference [2])
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Name
                                                Unk04
                                                Type
                                                nrps-type1
                                                Genes
                                                copB
                                                Substrates
                                                valine (evidence: Structure-based inference [2])
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Name
                                                Unk05
                                                Type
                                                nrps-type1
                                                Genes
                                                copB
                                                Substrates
                                                2,3-diaminopropionic acid (evidence: Structure-based inference [2])
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Name
                                                Unk06
                                                Type
                                                nrps-type1
                                                Genes
                                                copB
                                                Substrates
                                                3S-methylaspartic acid (evidence: Structure-based inference [2])
                                                Integrated Monomers
                                                Domains
                                                adenylation
                                                Annotation changelog

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Added chemical structures for compounds: coprisamide D, coprisamide C.
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-10-07
                                                Added NPAtlas links to compounds: coprisamide D, coprisamide C.
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Entry added
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Added NRP substrate specificities
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
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