BGC0002383 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002383 (Streptomyces sp. SN-593)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,507	High	kinanthraquinone B/kinanthraquinone	PKS

BGC0002383 - Region 1 - T2PKS

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Location: 1 - 72,507 nt. (total: 72,507 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,508
Label		BGC0002383

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

RVR_2907: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

RVR_2909: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

RVR_2912: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

RVR_2919: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

RVR_2924: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

RVR_2925: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

RVR_2930: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

RVR_2938: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase glycosyltransferase methyltransferase transferase

RVR_2916: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

RVR_2927: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

RVR_2929: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

RVR_2931: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

RVR_2935: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: cyclase dehydratase

RVR_2902: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

RVR_2908: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

RVR_2932: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

RVR_2934: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

RVR_2903: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

RVR_2904: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002383.3	1.00	PKS	kinanthraquinone B, kinanthraquinone	Streptomyces sp. SN-593
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.78	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000278.3	0.72	PKS	urdamycin	Streptomyces fradiae
BGC0001723.5	0.66	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0002047.2	0.60	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0001817.5	0.59	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0002477.3	0.57	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002383.3	1.00	PKS	kinanthraquinone B, kinanthraquinone	Streptomyces sp. SN-593
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.78	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000278.3	0.72	PKS	urdamycin	Streptomyces fradiae
BGC0001723.5	0.66	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0002047.2	0.60	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0001817.5	0.59	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0002477.3	0.57	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72507
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 713.4; E-value: 1.6e-217)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 591 Da
acetyl-CoA_9: 633 Da

RVR_2902: CYC C4-C17/C2-C19 (Score: 199.4; E-value: 1.2e-61)
RVR_2903: KS (Score: 791.8; E-value: 3.1e-241)
RVR_2904: CLF 8|9 (Score: 713.4; E-value: 1.6e-217)
RVR_2905: ACP (Score: 139.4; E-value: 6.7e-44)
RVR_2907: KR C9 (Score: 493.3; E-value: 3.4e-151)
RVR_2908: CYC C7-C12 (Score: 502.1; E-value: 1.1e-153)
RVR_2909: OXY (Score: 599.6; E-value: 1e-182)
RVR_2912: OXY (Score: 593.7; E-value: 6.3e-181)
RVR_2916: GT (Score: 400.1; E-value: 3.2e-122)
RVR_2925: OXY (Score: 479.4; E-value: 3.1e-146)
RVR_2927: MET (Score: 282.0; E-value: 1.5e-86)
RVR_2929: MET (Score: 273.3; E-value: 6.3e-84)