BGC0002384: lysocin E biosynthetic gene cluster from Lysobacter sp.
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Location: 1 - 85,800 nt. (total: 85,800 nt).
This entry is originally from NCBI GenBank MT410681.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002384
Short description lysocin E biosynthetic gene cluster from Lysobacter sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MT410681.1
1 - 85800
via Knock-out studies
Compounds
  • lysocin E
Species Lysobacter sp. [taxonomy]
References
Chemical products information
lysocin E Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QWM97301.1
 1 - 627 (-) polysaccharide export protein
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    • QWM97302.1
    		 890 - 1030 (+) hypothetical protein
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      • QWM97303.1
      		 1093 - 2607 (-) undecaprenyl-phosphate glucose phosphotransferase
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        • QWM97304.1
        		 3442 - 4281 (-) porin family protein
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          • QWM97305.1
          		 4455 - 5228 (+) hypothetical protein
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            • QWM97306.1
            		 5306 - 5929 (+) sigma-70 family RNA polymerase sigma factor
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              • QWM97307.1
              		 5926 - 6666 (+) hypothetical protein
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                • QWM97308.1
                		 7047 - 7808 (+) acyl-CoA desaturase
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                  • QWM97309.1
                  		 7811 - 9118 (+) FAD-dependent oxidoreductase
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                    • QWM97310.1
                    		 9115 - 9909 (+) hypothetical protein
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                      • QWM97311.1
                      		 9906 - 11195 (+) class I SAM-dependent methyltransferase
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                        • QWM97312.1
                        		 11192 - 11734 (+) hypothetical protein
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                          • QWM97313.1
                          		 11731 - 12537 (+) hypothetical protein
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                            • QWM97314.1
                            		 12534 - 13625 (+) class I SAM-dependent methyltransferase
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                              • QWM97315.1
                              		 13714 - 14199 (+) hypothetical protein
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                                • QWM97316.1
                                		 15080 - 16066 (+) ATP-binding protein
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                                  • QWM97317.1
                                  		 16063 - 16470 (+) hypothetical protein
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                                    • QWM97318.1
                                    		 17560 - 19320 (+) ABC transporter ATP-binding protein
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                                      • QWM97319.1
                                      		 19406 - 47104 (+) non-ribosomal peptide synthetase
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                                        • QWM97320.1
                                        		 47085 - 66500 (+) non-ribosomal peptide synthetase
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                                          • QWM97321.1
                                          		 66557 - 66787 (+) MbtH family protein
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                                            • QWM97322.1
                                            		 68345 - 68671 (-) copper amine oxidase
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                                              • QWM97323.1
                                              		 68968 - 70797 (-) NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit
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                                                • QWM97324.1
                                                		 70794 - 71486 (-) hypothetical protein
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                                                  • QWM97325.1
                                                  		 71557 - 74265 (-) TonB-dependent receptor
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                                                    • QWM97326.1
                                                    		 74901 - 75635 (+) histidine utilization repressor
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                                                      • QWM97327.1
                                                      		 75945 - 77294 (+) hypothetical protein
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                                                        • QWM97328.1
                                                        		 77278 - 77652 (+) hypothetical protein
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                                                          • QWM97329.1
                                                          		 78569 - 79450 (+) alpha/beta hydrolase
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                                                            • QWM97330.1
                                                            		 79622 - 80266 (-) glutathione S-transferase
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                                                              • QWM97331.1
                                                              		 80569 - 80829 (-) hypothetical protein
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                                                                • QWM97332.1
                                                                		 80854 - 81294 (-) hypothetical protein
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                                                                  • QWM97333.1
                                                                  		 81816 - 83807 (+) sulfatase
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                                                                    • QWM97334.1
                                                                    		 83929 - 85800 (-) ABC transporter ATP-binding protein
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                                                                      Biosynthesis information

                                                                      Biosynthetic modules

                                                                      Name
                                                                      Unk01
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97319.1
                                                                      Substrates
                                                                      threonine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk02
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97319.1
                                                                      Substrates
                                                                      arginine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk03
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97319.1
                                                                      Substrates
                                                                      serine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk04
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97319.1
                                                                      Substrates
                                                                      glycine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk05
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97319.1
                                                                      Substrates
                                                                      phenylalanine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk06
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97319.1
                                                                      Substrates
                                                                      leucine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk07
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97319.1
                                                                      Substrates
                                                                      arginine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk08
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97320.1
                                                                      Substrates
                                                                      glutamic acid (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk09
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97320.1
                                                                      Substrates
                                                                      glutamine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk10
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97320.1
                                                                      Substrates
                                                                      tryptophan (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk11
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97320.1
                                                                      Substrates
                                                                      isoleucine, valine (evidence: Structure-based inference, Mass spectrometry)
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Name
                                                                      Unk12
                                                                      Type
                                                                      nrps-type1
                                                                      Genes
                                                                      QWM97320.1
                                                                      Substrates
                                                                      threonine (evidence: Structure-based inference [2])
                                                                      Integrated Monomers
                                                                      Domains
                                                                      adenylation
                                                                      Annotation changelog

                                                                      Entry version: 2

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-10-07
                                                                      Added chemical structures for compounds: lysocin E.
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2022-10-07
                                                                      Added NPAtlas links to compounds: lysocin E.
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2022-10-07
                                                                      Renamed compounds: lysocin to lysocin E.
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 1

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-09-15
                                                                      Entry added
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2022-09-15
                                                                      Added NRP substrate specificities
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      Detailed domain annotation
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