BGC0002385: dumulmycin biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 87,287 nt. (total: 87,287 nt).
This entry is originally from NCBI GenBank MZ150741.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002385
Short description dumulmycin biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
MZ150741.1
1 - 87287
via Heterologous expression, Knock-out studies
Compounds
  • dumulmycin
Species Streptomyces sp. [taxonomy]
References
Chemical products information
dumulmycin Evidence: NMR [1]
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C33H48O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QZA73300.1
 190 - 1281 (-) peptidase M23
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    • QZA73301.1
    		 1783 - 2481 (-) putative endonuclease
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      • QZA73302.1
      • sdlA
      		 2685 - 3359 (-) 4'-phosphopantetheinyl transferase
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        • QZA73303.1
        • sdlB
        		 3717 - 4946 (-) cytochrome P450
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          • QZA73304.1
          • sdlC
          		 5656 - 6039 (+) DUF4180 domain-containing protein
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            • QZA73305.1
            • sdlD
            		 6582 - 29939 (+) type I polyketide synthase
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              • QZA73306.1
              • sdlE
              		 29942 - 43618 (+) type I polyketide synthase
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                • QZA73307.1
                • sdlF
                		 43615 - 52080 (+) type I polyketide synthase
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                  • QZA73308.1
                  • sdlG
                  		 52073 - 61048 (+) type I polyketide synthase
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                    • QZA73309.1
                    • sdlH
                    		 61050 - 70265 (+) type I polyketide synthase
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                      • QZA73310.1
                      • sdlI
                      		 70262 - 71623 (+) 2-nitropropane dioxygenase
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                        • QZA73311.1
                        • sdlJ
                        		 71714 - 72805 (+) malonyl CoA-acyl carrier protein transacylase
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                          • QZA73312.1
                          • sdlK
                          		 72847 - 74106 (+) hydroxymethylglutaryl-CoA synthase
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                            • QZA73313.1
                            • sdlL
                            		 74094 - 74879 (+) enoyl-CoA hydratase/isomerase
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                              • QZA73314.1
                              • sdlM
                              		 74882 - 75634 (+) enoyl-CoA hydratase
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                                • QZA73315.1
                                • sdlN
                                		 75639 - 75884 (+) acyl carrier protein
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                                  • QZA73316.1
                                  • sdlO
                                  		 75865 - 77112 (+) beta-ketoacyl synthase
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                                    • QZA73317.1
                                    • sdlP
                                    		 77162 - 78127 (+) malonyl CoA-acyl carrier protein transacylase
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                                      • QZA73318.1
                                      • sdlQ
                                      		 78162 - 79025 (+) SDR family oxidoreductase
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                                        • QZA73319.1
                                        • sdlR
                                        		 79090 - 82989 (+) SDR family oxidoreductase
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                                          • QZA73320.1
                                          		 84350 - 86005 (+) multicopper oxidase family protein
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                                            Biosynthesis information

                                            No biosynthesis information available for this record.

                                            Annotation changelog

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2024-04-23
                                            MIBiG v4 annotathon
                                            • (ID: GLNIA6HUGFRXN2FRDQ7ILDE7)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Changed chemical structures for compounds: shuangdaolide A, shuangdaolide D, shuangdaolide C, shuangdaolide B.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-10-07
                                            Added chemical structures for compounds: dumulmycin.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-10-07
                                            Added NPAtlas links to compounds: shuangdaolide A, shuangdaolide D, shuangdaolide C, shuangdaolide B, dumulmycin.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Entry added
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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