BGC0002426 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002426 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS,indole	1	52,935	High	deschlorosvetamycin A/svetamycin H/svetamycin A	NRPS:Type I

BGC0002426 - Region 1 - T2PKS,indole

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Location: 1 - 52,935 nt. (total: 52,935 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 52,936
Label		BGC0002426

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

babD: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

babF: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

babO1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

babO2: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

babO3: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

babO4: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

babU: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

babX: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: halogenase methyltransferase

babH1: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

babH2: flavin-dependent trp 6 7 halogenase

halogenases: flavin-dependent trp 6 7 halogenase
MITE: MITE0000092Halogenation (identity: 70.40%)
smcogs: SMCOG1119: halogenase

babM1: methyltransferase

smcogs: SMCOG1089: methyltransferase

babM2: methyltransferase

smcogs: SMCOG1089: methyltransferase

babM3: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

babM4: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: dehalogenase hydrolase

babA: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

babV: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: cyclase

babG: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

babI: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

babK: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

babL: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002426.3	1.48	NRPS	deschlorosvetamycin A, svetamycin H, svetamycin A	Streptomyces sp.
BGC0001512.5	0.85	PKS	BE-24566B	Streptomyces sp.
BGC0001224.5	0.66	other (other)	reductasporine	uncultured bacterium
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001336.5	0.53	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0001366.5	0.52	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002341.2	0.47	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.46	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001223.5	0.46	other (other)	hydroxysporine	uncultured bacterium
BGC0002631.2	0.42	ribosomal	Myxarylin	Pyxidicoccus fallax

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002426.3	1.00	NRPS	deschlorosvetamycin A, svetamycin H, svetamycin A	Streptomyces sp.
BGC0001512.5	0.88	PKS	BE-24566B	Streptomyces sp.
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001513.3	0.72	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001366.5	0.69	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0001224.5	0.66	other (other)	reductasporine	uncultured bacterium
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001336.5	0.61	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 52935
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 666.3; E-value: 3e-203)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: acetyl-CoA_11: 556 Da
acetyl-CoA_12: 598 Da

babF: KR (Score: 141.8; E-value: 7.4e-44)
babG: CYC C4-C21/C2-C23|C2-C19 (Score: 135.7; E-value: 1.2e-42)
babH1: HAL (Score: 409.0; E-value: 5.6e-125)
babI: CYC C9-C14 (Score: 243.0; E-value: 2.2e-75)
babJ: ACP (Score: 73.4; E-value: 2.6e-23)
babK: CLF 11|12 (Score: 666.3; E-value: 3e-203)
babL: KS (Score: 749.2; E-value: 2.6e-228)
babM1: MET (Score: 24.3; E-value: 3.4e-08)
babM3: MET C6|C8 (Score: 474.6; E-value: 3.2e-145)
babM4: MET (Score: 181.5; E-value: 5.5e-56)
babN: CYC C5-C18 (Score: 210.4; E-value: 1.7e-65)
babO2: OXY (Score: 240.3; E-value: 1e-73)
babO3: OXY (Score: 234.2; E-value: 7.2e-72)