BGC0002429: higginsianin B biosynthetic gene cluster from Colletotrichum higginsianum IMI 349063
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Location: 408,595 - 480,233 nt. (total: 71,639 nt).
This entry is originally from NCBI GenBank CM004458.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002429
Short description higginsianin B biosynthetic gene cluster from Colletotrichum higginsianum IMI 349063
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
  • terpene (Diterpene)
Loci
CM004458.1
408595 - 480233
via Heterologous expression
Compounds
  • higginsianin B
  • higginsianin A
  • higginsianin C
  • 13-epi-higginsianin C
  • higginsianin D
  • higginsianin E
Species Colletotrichum higginsianum IMI 349063 [taxonomy]
References
Chemical products information
higginsianin B Evidence: NMR [1]
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C27H40O4
Chemical database entries
NPAtlas
PubCHEM
higginsianin A Evidence: NMR [1]
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C28H40O4
Chemical database entries
PubCHEM
NPAtlas
higginsianin C Evidence: NMR [2]
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C27H40O5
Chemical database entries
ChEMBL
PubCHEM
ChEBI
13-epi-higginsianin C Evidence: NMR [2]
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C27H40O5
Chemical database entries
ChEMBL
PubCHEM
ChEBI
higginsianin D Evidence: NMR [3]
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C28H42O5
Chemical database entries
PubCHEM
ChEBI
higginsianin E Evidence: NMR [3]
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C28H42O5
Chemical database entries
PubCHEM
ChEBI
ChEMBL
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CH63R_05473
  • OBR09781.1
 408595 - 415269 (-) Non-reducing polyketide synthase
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    • CH63R_05474
    • OBR09782.1
    		 417007 - 417283 (+) hypothetical protein
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      • CH63R_05475
      • OBR09783.1
      		 417972 - 419631 (+) FAD-dependent epoxidase
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        • CH63R_05476
        • OBR09784.1
        		 420273 - 421094 (-) Terpene cyclase
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          • CH63R_05477
          • OBR09785.1
          		 421968 - 422890 (-) Short-chain dehydrogenase
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            • CH63R_05478
            • OBR09786.1
            		 443325 - 444487 (+) Prenyltransferase
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              • CH63R_05479
              • OBR09787.1
              		 444934 - 446438 (-) Short-chain dehydrogenase
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                • CH63R_05480
                • OBR09788.1
                		 447857 - 449066 (+) Geranylgeranyl pyrophosphate synthase
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                  • CH63R_05481
                  • OBR09789.1
                  		 449596 - 451482 (-) Cyclohexanone 1,2-monooxygenase
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                    • CH63R_05482
                    • OBR09790.1
                    		 478812 - 480233 (-) FAD-dependent oxidoreductase
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                      Biosynthesis information
                      Annotation changelog

                      Entry version: next

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2024-07-23
                      MIBiG v4 annotathon
                      • (ID: VMOLOUVCS4IRTX6AW6KNNWOL)
                      • (ID: IGMARHSR3IS5UOGRYN2CEMQD)
                      • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: next

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2023-10-17
                      Changed stop coordiante of locus entry to include genes CH63R_05473 and CH63R_05482 according to doi:10.1021/acs.jnatprod.5b00779. Added references to publications pertaining to the changes.
                      • (ID: 7S2S3KC6XWEGKGTSIW66GBJX)
                      • (ID: C62OJVVH7XOTOTFZSJT727YU)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Entry added
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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