BGC0002430: gausemycin A biosynthetic gene cluster from Streptomyces kanamyceticus
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Location: 1 - 121,518 nt. (total: 121,518 nt).
This entry is originally from NCBI GenBank MZ394730.1.

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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002430
Short description gausemycin A biosynthetic gene cluster from Streptomyces kanamyceticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • saccharide (None)
Loci
MZ394730.1
via
Compounds
  • gausemycin A
  • gausemycin B
Species Streptomyces kanamyceticus [taxonomy]
References
Chemical products information
gausemycin A Evidence:
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Chemical database entries
NPAtlas
gausemycin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QWT72257.1
  • orf1
 1 - 1215 (+) calcineurin
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    • QWT72258.1
    • orf2
    		 1208 - 2257 (-) alcohol dehydrogenase
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      • QWT72259.1
      • orf3
      		 2422 - 3342 (+) hypothetical protein
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        • QWT72260.1
        • orf4
        		 3342 - 4274 (+) Ku protein
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          • QWT72261.1
          • orf5
          		 4366 - 4692 (-) hypothetical protein
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            • QWT72262.1
            • orf6
            		 4759 - 5772 (-) SDR family oxidoreductase
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              • QWT72263.1
              • orf7
              		 5833 - 7017 (-) Zn-dependent alcohol dehydrogenase
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                • QWT72264.1
                • orf8
                		 7341 - 7514 (-) CsbD family protein
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                  • QWT72265.1
                  • orf9
                  		 7668 - 8651 (-) hypothetical protein
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                    • QWT72266.1
                    • orf10
                    		 8815 - 9786 (-) SDR family oxidoreductase
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                      • QWT72267.1
                      • orf11
                      		 10116 - 11279 (+) acyl-CoA dehydrogenase
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                        • QWT72268.1
                        • orf12
                        		 11283 - 12209 (-) hypothetical protein
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                          • QWT72269.1
                          • orf13
                          		 12206 - 13240 (-) isocitrate/isopropylmalate dehydrogenase family protein
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                            • QWT72270.1
                            • orf14
                            		 13256 - 13861 (-) 3-isopropylmalate dehydratase small subunit
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                              • QWT72271.1
                              • orf15
                              		 13914 - 15308 (-) 3-isopropylmalate dehydratase large subunit
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                                • QWT72272.1
                                • orf16
                                		 15305 - 16489 (-) pyruvate carboxyltransferase
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                                  • QWT72273.1
                                  • orf17
                                  		 16730 - 17785 (+) glycosyltransferase
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                                    • QWT72274.1
                                    • orf18
                                    		 17994 - 18896 (+) winged helix-turn-helix transcriptional regulator
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                                      • QWT72275.1
                                      • orf19
                                      		 18981 - 20795 (+) fatty acyl-AMP ligase
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                                        • QWT72276.1
                                        • orf20
                                        		 20792 - 22498 (+) acyl-CoA dehydrogenase
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                                          • QWT72277.1
                                          • orf21
                                          		 22495 - 24240 (+) acyl-CoA dehydrogenase
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                                            • QWT72278.1
                                            • orf22
                                            		 24305 - 24568 (+) hypothetical protein
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                                              • QWT72279.1
                                              • gauA
                                              		 24626 - 49969 (+) non-ribosomal peptide synthetase
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                                                • QWT72280.1
                                                • orf24
                                                		 50071 - 51357 (+) cytochrome P450
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                                                  • QWT72281.1
                                                  • orf25
                                                  		 51382 - 52338 (+) TauD/TfdA family dioxygenase
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                                                    • QWT72282.1
                                                    • orf26
                                                    		 52370 - 53551 (+) pyridoxal phosphate-dependent aminotransferase
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                                                      • QWT72283.1
                                                      • orf27
                                                      		 53560 - 55482 (+) ABC transporter ATP-binding protein
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                                                        • QWT72284.1
                                                        • gauE
                                                        		 55479 - 56933 (+) hypothetical protein
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                                                          • QWT72285.1
                                                          • orf29
                                                          		 56954 - 57613 (-) response regulator transcription factor
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                                                            • QWT72286.1
                                                            • orf30
                                                            		 57817 - 58776 (+) ABC transporter ATP-binding protein
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                                                              • QWT72287.1
                                                              • orf31
                                                              		 58781 - 59584 (+) ABC transporter permease
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                                                                • QWT72288.1
                                                                • orf32
                                                                		 60080 - 61081 (+) winged helix-turn-helix transcriptional regulator
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                                                                  • QWT72289.1
                                                                  • orf33
                                                                  		 61111 - 61620 (-) flavin reductase family protein
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                                                                    • QWT72290.1
                                                                    • orf34
                                                                    		 61886 - 62098 (+) MbtH family protein
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                                                                      • QWT72291.1
                                                                      • gauB
                                                                      		 62280 - 65432 (+) amino acid adenylation domain-containing protein
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                                                                        • QWT72292.1
                                                                        • gauC
                                                                        		 65711 - 83146 (+) putative non-ribosomal peptide synthetase
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                                                                          • QWT72293.1
                                                                          • gauD
                                                                          		 83143 - 90369 (+) non-ribosomal peptide synthetase
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                                                                            • QWT72294.1
                                                                            • orf38
                                                                            		 90309 - 91949 (-) histidine kinase
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                                                                              • QWT72295.1
                                                                              • orf39
                                                                              		 92209 - 92424 (+) argininosuccinate lyase
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                                                                                • QWT72296.1
                                                                                • orf40
                                                                                		 92418 - 93329 (+) kinase
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                                                                                  • QWT72297.1
                                                                                  • orf41
                                                                                  		 93402 - 94388 (-) hypothetical protein
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                                                                                    • QWT72298.1
                                                                                    • orf42
                                                                                    		 94571 - 95419 (+) alpha/beta hydrolase
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                                                                                      • QWT72299.1
                                                                                      • orf43
                                                                                      		 95416 - 96144 (+) tryptophan 2,3-dioxygenase
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                                                                                        • QWT72300.1
                                                                                        • orf44
                                                                                        		 96457 - 98055 (+) tryptophan 7-halogenase
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                                                                                          • QWT72301.1
                                                                                          • orf45
                                                                                          		 98077 - 99366 (+) cation/H(+) antiporter
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                                                                                            • QWT72302.1
                                                                                            • orf46
                                                                                            		 99373 - 100626 (+) decarboxylase
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                                                                                              • QWT72303.1
                                                                                              • orf47
                                                                                              		 100661 - 101122 (-) NUDIX domain-containing protein
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                                                                                                • QWT72304.1
                                                                                                • orf48
                                                                                                		 101169 - 102692 (-) long-chain fatty acid--CoA ligase
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                                                                                                  • QWT72305.1
                                                                                                  • orf49
                                                                                                  		 102705 - 103757 (-) aminoglycoside phosphotransferase family protein
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                                                                                                    • QWT72306.1
                                                                                                    • orf50
                                                                                                    		 103754 - 104947 (-) hypothetical protein
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                                                                                                      • QWT72307.1
                                                                                                      • orf51
                                                                                                      		 105002 - 105643 (-) hypothetical protein
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                                                                                                        • QWT72308.1
                                                                                                        • orf52
                                                                                                        		 105669 - 106472 (-) class I SAM-dependent methyltransferase
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                                                                                                          • QWT72309.1
                                                                                                          • orf53
                                                                                                          		 106466 - 107470 (-) hypothetical protein SMALA_6641
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                                                                                                            • QWT72310.1
                                                                                                            • orf54
                                                                                                            		 107850 - 108836 (+) aldo/keto reductase
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                                                                                                              • QWT72311.1
                                                                                                              • orf55
                                                                                                              		 108899 - 109669 (+) glucose 1-dehydrogenase
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                                                                                                                • QWT72312.1
                                                                                                                • orf56
                                                                                                                		 109732 - 110808 (+) myo-inositol-1-phosphate synthase
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                                                                                                                  • QWT72313.1
                                                                                                                  • orf57
                                                                                                                  		 110815 - 111618 (+) histidinol-phosphatase
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                                                                                                                    • QWT72314.1
                                                                                                                    • orf58
                                                                                                                    		 111660 - 112877 (+) S-adenosylmethionine synthetase
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                                                                                                                      • QWT72315.1
                                                                                                                      • orf59
                                                                                                                      		 112871 - 113893 (+) hypothetical protein
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                                                                                                                        • QWT72316.1
                                                                                                                        • orf60
                                                                                                                        		 113890 - 114456 (+) hypothetical protein
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                                                                                                                          • QWT72317.1
                                                                                                                          • orf61
                                                                                                                          		 114449 - 115726 (+) DegT/DnrJ/EryC1/StrS family aminotransferase
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                                                                                                                            • QWT72318.1
                                                                                                                            • orf62
                                                                                                                            		 115741 - 116232 (+) NUDIX domain-containing protein
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                                                                                                                              • QWT72319.1
                                                                                                                              • orf63
                                                                                                                              		 116262 - 116996 (-) class I SAM-dependent methyltransferase
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                                                                                                                                • QWT72320.1
                                                                                                                                • orf64
                                                                                                                                		 117123 - 117446 (+) hypothetical protein
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                                                                                                                                  • QWT72321.1
                                                                                                                                  • orf65
                                                                                                                                  		 117512 - 118261 (+) HAD hydrolase family protein
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                                                                                                                                    • QWT72322.1
                                                                                                                                    • orf66
                                                                                                                                    		 118273 - 119295 (-) UDP-glucose 4-epimerase
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                                                                                                                                      • QWT72323.1
                                                                                                                                      • orf67
                                                                                                                                      		 119477 - 120388 (+) hypothetical protein
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                                                                                                                                        • QWT72324.1
                                                                                                                                        • orf68
                                                                                                                                        		 120388 - 121518 (+) hypothetical protein
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                                                                                                                                          Biosynthesis information
                                                                                                                                          Annotation changelog

                                                                                                                                          Entry version: 2

                                                                                                                                          Date
                                                                                                                                          Changes
                                                                                                                                          Submitters
                                                                                                                                          Reviewers
                                                                                                                                          2022-10-07
                                                                                                                                          Added chemical structures for compounds: gausemycin B, gausemycin A.
                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                          2022-10-07
                                                                                                                                          Added NPAtlas links to compounds: gausemycin B, gausemycin A.
                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                          Entry version: 1

                                                                                                                                          Date
                                                                                                                                          Changes
                                                                                                                                          Submitters
                                                                                                                                          Reviewers
                                                                                                                                          2022-09-15
                                                                                                                                          Entry added
                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                          Detailed domain annotation
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