LOCUS       BGC0002434             19176 bp    DNA     linear   BCT 15-JUN-2021
DEFINITION  Kitasatospora sp. strain S023 PoTeM biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0002434
VERSION     BGC0002434
KEYWORDS    .
SOURCE      Kitasatospora sp
  ORGANISM  Kitasatospora sp.
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:42:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 19176
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1530)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 380.4; E-value:
                     1.6e-115)"
                     /gene_kind="transport"
                     /product="MFS transporter"
                     /protein_id="QWM97859.1"
                     /transl_table=11
                     /translation="MRTWGPLVAVCLGVFMLLTDVSIVIVALPDIGAGLDMDFDGLQWV
                     LDGYALALAALLLGLGALADRVGRRRVYTVGLAVFALASLACGLAPDGATLVGARIVQA
                     GGGAAMFATAMALLNLSYRGRDRAVAFGVWGSVSGAAAAVGPVAGGLLTEYLGWRSIFL
                     VNLPLALAAVVLARRTLPESRDPGARRLDLPGAASFTVAAGAAVLGLIRGGTDGWTSPA
                     VLGAGTAAVVALAVFALVERLSAHPLLAPALLRRPAFTGVLLCGAVYSATAFSGLPYIS
                     LWLQSVLGLGPMAAGLTLLPMSVVAFAVPALAGRRLAALPVAVPLAGGLAVIGLGTLLQ
                     GALDGSSGWTALLPGLALTGLGIGAVSPVLASAAMAAVPPERGGMAGGALNTFRQLGQA
                     LGIAVLGLVLHGGLRDALAGHPAAGPDPDATAGALASGRPPAGLPGELLRTAFATGLDR
                     TLLAAGLTALAGAALVAVLLRRRPERAGSPDDQSPAVLEAPGPNRHQTAGR"
     source          1..19176
                     /country="China: Mountain Taishan"
                     /db_xref="taxon:1871188"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Kitasatospora sp."
                     /strain="S023"
     misc_feature    1..19176
                     /note="PoTeM biosynthetic gene cluster"
     subregion       1..19176
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS, NRPS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19176
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             1668..2705
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120:AsnC family
                     transcriptional regulator (Score: 115; E-value: 3.6e-35)"
                     /gene_kind="regulatory"
                     /product="AsnC family transcriptional regulator"
                     /protein_id="QWM97860.1"
                     /transl_table=11
                     /translation="MTLDGLDRALLHALHVDGRAPFRRIAEVLGVSDQTVARRYQRLRA
                     AGVVRVVGRTDARLLGQVDWLTRIRCVPDAAAPLAEALARRPDTSWVSLLSGGEIVCNA
                     RARLRPEREELLLGALPRSPRVLSVSAHYLLRTYVGGQVAWSGRTSALTDGQIARLRAA
                     AGTGPTAAKAPGLPHVPGVPDVPDVPDVLDVLDVLDRALLAALAVDGRAPLAALAAASG
                     SPETTVRRRLAALVDGGLLFFDVDVDPRPLGFEVEAFCWLTVAPGRLAAVGRAMAEHPE
                     VGFVAATTGPSNLVAGLVCRDTGAFYDYLTQGLGELEGVVAVETAPLLRSVKRAGMIMP
                     SSNNP"
     gene            2886..3764
                     /gene="cftE"
     CDS             2886..3764
                     /codon_start=1
                     /gene="cftE"
                     /product="fatty acid hydroxylase family protein"
                     /protein_id="QWM97861.1"
                     /transl_table=11
                     /translation="MGKRLRTVLRHVAYPFLLVTLVGIAVAALRLRWDLDRVNQLFLLG
                     VIAFMSLLERLIPYEPEWSPSVREWGWYGVYFLLTMIGGALSQVPVAALVGWLAPPRSA
                     LPPWVEIPAALLLGSLANYLVHRWCHTSPRLWRLHGVHHVPDKVNVGNNGVNHLLDVLL
                     TQGAVQLALAAAGFSAPTVFVVGLFVVAQGYFVHANIDVRIGPLNYVLAGPEQHRLHHS
                     TDLAEAGHYGSDLSVWDHVFGSFTWRPGRRPLAVGLANPADFPATGRVVASHLQAWHRP
                     ARAERSPTGTT"
     gene            3998..13540
                     /gene="cftB"
     CDS             3998..13540
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (34-461). E-value:
                     6.7e-174. Score: 570.6. Matches aSDomain:
                     nrpspksdomains_cftB_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (603-904). E-value: 1.1e-99.
                     Score: 325.4. Matches aSDomain:
                     nrpspksdomains_cftB_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (966-1124). E-value: 9.5e-36.
                     Score: 115.5. Matches aSDomain:
                     nrpspksdomains_cftB_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1500-1693). E-value: 4.3e-58.
                     Score: 188.1. Matches aSDomain:
                     nrpspksdomains_cftB_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1780-1863). E-value: 3.4e-16.
                     Score: 51.3. Matches aSDomain:
                     nrpspksdomains_cftB_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1887-2183). E-value:
                     5.5e-87. Score: 283.4. Matches aSDomain:
                     nrpspksdomains_cftB_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (2352-2768). E-value:
                     1.9e-96. Score: 315.0. Matches aSDomain:
                     nrpspksdomains_cftB_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (2879-2940). E-value:
                     8.7e-13. Score: 40.5. Matches aSDomain:
                     nrpspksdomains_cftB_PP-binding.1"
                     /NRPS_PKS="Domain: Thioesterase (2963-3101). E-value:
                     1.6e-29. Score: 95.8. Matches aSDomain:
                     nrpspksdomains_cftB_Thioesterase.1"
                     /codon_start=1
                     /gene="cftB"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 282.6; E-value:
                     9.5e-86)"
                     /gene_kind="biosynthetic"
                     /product="hybrid non-ribosomal peptide synthetase/type I
                     polyketide synthase"
                     /protein_id="QWM97862.1"
                     /sec_met_domain="PKS_KS (E-value: 1.1e-174, bitscore:
                     570.6, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.8e-100, bitscore:
                     325.4, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 9.1e-52, bitscore:
                     164.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.5e-14, bitscore:
                     41.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.5e-65, bitscore:
                     210.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-106, bitscore:
                     344.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSRFVTSPDLPEPSERPVPGGPPAAPGAGREKIAIIGIGCRLP
                     GGASDHRTYWQNLLDGKDCITPTPRSRYDVATLGSRDKAKPGRLVGGRGGYIDGFDEFD
                     PAFFGISGREADHMDPQQRKLLEVAWEALEDGGQKPAELAGREVGVYVGAFTLDYKIVQ
                     FSDLSFDTLAAHTATGTMMTMVSNRISHCFDFRGPSVSLDTACSSSLVAVHLAVQSLQR
                     GETDLALAGGTLLHIAPQYTIAETKGGFLSPQGRSRTFDASADGYVRAEGVAVVALKRL
                     SDALRDGDPVHAVVIGSGVNQDGRTNGITVPNPDAQVTLIERVCAEAGIVPGSLQYVEA
                     HGTSTPVGDPIEAGALARALAVGRRPGDKCYVGSVKTNIGHTESASGLAGLIKSALALK
                     HRTVPPHINLERLNPAIDPAALPYEIPTEVTPWPEHEGPARAGVNSFGFGGTNAHVLLE
                     AAPEPSPELSPELSPVSVPAPAGAADNATADAGGTGHGPAAGRPRWTVLPLTAREAAAL
                     PELAAGVQAELAGVRGGSPARPADLGHTLAHRRQHHDARLSVVYDAREHAARASLDEAL
                     TAHLRGEPHPRVLTGHRREARHRRLAWVFTGMGPQWWAMGRRLLATEPVYREAVESCAE
                     HLAELAGWSLIDELTADEADSRMAETWLAQPANFAVQTGLAALWRSRGVRPDAIVGHST
                     GEVAAFYEAGVYDLADAVKVVFHRSRLQQELAGTGGMLAVSLTEAEALRRIRPYGGAVS
                     VAAVNSPTALTLAGDAPALAELAAALTAEQVFARPLTVEVPYHSARMDLIKDELLESLA
                     DIKARPAQTPLYLTGREGTARGTELDAGYWWHNVRDSVRFRQAVERLADDGYGLFLEIG
                     PHPVLGRSIQETVEAHPGTADRPEPRTLPSIRRQEDEQATFTASLAALHNLGVEVDWSV
                     LQPAGRIVPLPRYPFRRDRHWVEPRAVAEVRQGLVDHPLLGRRLPGAEPAWEARLDAEA
                     LPYLEDHRIQGDVVFPAAGYLEMAVQAVRALTGGTDAALADIELRKALLLPDDESRAVR
                     LTLCAEQGTFTVATGEGRERTVHAVGTVRPGQRRRPGRPLDAEAVRGRALRRLAGADCY
                     AGLAALGYHYGPAFQGIEEVWIGPGEALARIRPPAPVAGQGERHQVHPVVMDAFFQTLL
                     TPQLLADRPADARGIRLPVAIGEVRLDAVGDRPLWVHATVTRDAGAELLGDLAVYEEQG
                     APLGGVTGFRAADVERAATAVGLGTIDGWLAEPAWAELPAAGDAPDLLAEHPDHWLLFA
                     DGGGVADTLAERIAARGGSCLRVRPGTGYLAAADGRPATVEPGSAADLARLLADRRAGG
                     APDPAAVVHLWNLDRPGLATADPATAAGHTAPGAYSLVTLAALLAAELPDCRLHVITRA
                     AQAVAPGEAVEPLAAPAWGITRVLRHQELPTHQGKLIDLPATGIEAEAEAEAEAEALLR
                     EFALADEDEIALRGGRRLTSRLRTAEGLSRPLAPRLRADGAYLVTGAFGALGQLLCRTL
                     VKRGARRLILVGRSTPPPRESWRALDPESRDGQRAAFLRELEELGAEVVPAALDVTDEP
                     ALAAWLAEYRRLDRPPVRGVFHLAGQVRDTLVGELDRSAFDTVYGPKVLGALALHRQLA
                     GEPLDHFVLFASIASLLTTAGQTNYAAGNAFLDALAHHRRALGLPALSLDWGPWATGMI
                     EELGLIDHYRHSRGMSSLAPETGMAVLERVLGQDRAQLLVATVVDWPVFLSWYPAPPPL
                     VTELAAAARESAPAVERTGLLDTLRTAGEEERRALLTELFTELAATVLRVPADRVDPAA
                     GLGGLGLDSLLAMELRARLSGELGVTLPVVALLGNAPVAELVARLHESLTELLDEEPAG
                     PGAAGVERYEDESAHPLTHNQKALWFLKQLNPDGFAYNIGGAVEVRVELEPELMAAAFR
                     AMVERHPSLRANFTLDAGRAVQRISAEVEPDFDVFDVEHLAWDDIHAMIVREYRRPYDL
                     ERDPLVRFRLFRRGPARWVIMKAVHHIISDAISTFTFIEELLAVYEGLRRGRAPELPPV
                     AARYLDFLNRQNAFLAGREAPRMLEYWRSHLPAEVPLLSLPTDKPRPAVQTHNGASEFF
                     VLDEELSARVHALARAHNVTVFMVLLSAYYLLLHAYAGQEDIIVGSPVTGRTDEEFAGV
                     YGYFVNPLPLHVSLAGGPTVAELLERVRTTVLGGLDHQEYPFVLLVEQLGLQHDPSRSA
                     VFQAMFILLHHKVATEKYGYHLEYIELPEEEGQFDLTLSAYEDEAERRFHCVFKYNTDL
                     FLPGTTARMARHYVNLLDALTTAGPERAATGLELLGERERSVVLREWSGADRRVPFAEP
                     VHELVLRAAAADPAAPAVAVPAESGPTVRLTYGELAGRSRRAAVRLRALGAGPGTVVAL
                     CLEKSPELIVALLAVLRTGAAYLPLDPGHPVERLAYLVGHTGAGLLVGDDRERLGGLPA
                     RLVTTAELGADGTTGADDPDGEGFADVPVGLDDPAYVIHTSGSTGRPKAVRVSHGNLAS
                     AYRAWQSEYRLDTDARTHLQMAGPAFDVFTGDVVRALCSGGTLVLVGRELLFNTARLYE
                     VMRTERVDAAEFVPAVVRTVLDHCERTGQDLAFMRLLVVGSDVWKVEEYRRLGALCGPR
                     TRLVNSYGLTETTIDSAYFEGPTDGLEPSRMVPIGRPFPNSAFHLLDAQGRPVPPGVTG
                     ELWIGGSGVALGYLGDEEQTARRFATLPLGGADGTEPVRLYRTGDLARWDADGGVHLLG
                     RADSQIKVRGHRIELGEIETRLAEWPELAGAVVTVRADRGGEHVLCAYCVPAPGRTFDH
                     RALRRHLAGQLPTFMIPTHFTELPALPLTANGKVDVAALPEPRTDAAEAADPPVTLYEV
                     RMAEHWRTLLGIEEPGLQHDFFESGGSSIRLIELIHGLQAEFNISIPVSQLFKVTTLHG
                     MAKTVEHIITGRIEGAQPYLGFNQEQRQTLFCFPPAGGHGLVYRQFAAHLPEYRTIAFN
                     YVSGDDKVDQYADLVEALQPEGPCALLGYSLGGNLAFEVAKELERRGRAVPNVVIMDSH
                     RIPESFDLADEHLQAFETELAEHLHRHTGSAAVARETREQARDYLRFCSRTPNHGVVAA
                     ALSVISDDEKVALYEAGRDGAWHGSSATRTAVFKGFGTHAEMLDREFIAHNAGLARSIL
                     TGAATHAS"
     aSDomain        4100..5380
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="6.70E-174"
                     /label="cftB_PKS_KS.1"
                     /locus_tag="cftB"
                     /protein_end="461"
                     /protein_start="34"
                     /score="570.6"
                     /tool="antismash"
                     /translation="IAIIGIGCRLPGGASDHRTYWQNLLDGKDCITPTPRSRYDVATLG
                     SRDKAKPGRLVGGRGGYIDGFDEFDPAFFGISGREADHMDPQQRKLLEVAWEALEDGGQ
                     KPAELAGREVGVYVGAFTLDYKIVQFSDLSFDTLAAHTATGTMMTMVSNRISHCFDFRG
                     PSVSLDTACSSSLVAVHLAVQSLQRGETDLALAGGTLLHIAPQYTIAETKGGFLSPQGR
                     SRTFDASADGYVRAEGVAVVALKRLSDALRDGDPVHAVVIGSGVNQDGRTNGITVPNPD
                     AQVTLIERVCAEAGIVPGSLQYVEAHGTSTPVGDPIEAGALARALAVGRRPGDKCYVGS
                     VKTNIGHTESASGLAGLIKSALALKHRTVPPHINLERLNPAIDPAALPYEIPTEVTPWP
                     EHEGPARAGVNSFGFGGTNAHVLLEAAP"
     aSModule        4100..9586
                     /complete
                     /domains="nrpspksdomains_cftB_PKS_KS.1"
                     /domains="nrpspksdomains_cftB_PKS_AT.1"
                     /domains="nrpspksdomains_cftB_PKS_DH.1"
                     /domains="nrpspksdomains_cftB_PKS_KR.1"
                     /domains="nrpspksdomains_cftB_PKS_PP.1"
                     /locus_tags="cftB"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       4586..4633
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0001"
                     /evalue="7.00E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="cftB"
                     /protein_end="212"
                     /protein_start="196"
                     /score="18.1"
                     /tool="antismash"
                     /translation="GPSVSLDTACSSSLVA"
     CDS_motif       4775..4813
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0002"
                     /evalue="2.70E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="cftB"
                     /protein_end="272"
                     /protein_start="259"
                     /score="14.0"
                     /tool="antismash"
                     /translation="FDASADGYVRAEG"
     CDS_motif       5006..5053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0003"
                     /evalue="1.20E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="cftB"
                     /protein_end="352"
                     /protein_start="336"
                     /score="11.3"
                     /tool="antismash"
                     /translation="YVEAHGTSTPVGDPIE"
     CDS_motif       5114..5158
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0004"
                     /evalue="1.10E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="cftB"
                     /protein_end="387"
                     /protein_start="372"
                     /score="11.5"
                     /tool="antismash"
                     /translation="GSVKTNIGHTESASG"
     CDS_motif       5804..5857
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0005"
                     /evalue="6.00E-03"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="cftB"
                     /protein_end="620"
                     /protein_start="602"
                     /score="9.6"
                     /tool="antismash"
                     /translation="WVFTGMGPQWWAMGRRLL"
     aSDomain        5807..6709
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_PKS_AT.1"
                     /evalue="1.10E-99"
                     /label="cftB_PKS_AT.1"
                     /locus_tag="cftB"
                     /protein_end="904"
                     /protein_start="603"
                     /score="325.4"
                     /tool="antismash"
                     /translation="VFTGMGPQWWAMGRRLLATEPVYREAVESCAEHLAELAGWSLIDE
                     LTADEADSRMAETWLAQPANFAVQTGLAALWRSRGVRPDAIVGHSTGEVAAFYEAGVYD
                     LADAVKVVFHRSRLQQELAGTGGMLAVSLTEAEALRRIRPYGGAVSVAAVNSPTALTLA
                     GDAPALAELAAALTAEQVFARPLTVEVPYHSARMDLIKDELLESLADIKARPAQTPLYL
                     TGREGTARGTELDAGYWWHNVRDSVRFRQAVERLADDGYGLFLEIGPHPVLGRSIQETV
                     EAHPGTADRPEPRTLPSIRR"
     CDS_motif       5987..6040
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0006"
                     /evalue="4.40E-04"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="cftB"
                     /protein_end="681"
                     /protein_start="663"
                     /score="13.5"
                     /tool="antismash"
                     /translation="AQPANFAVQTGLAALWRS"
     CDS_motif       6044..6154
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0007"
                     /evalue="5.10E-13"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="cftB"
                     /protein_end="719"
                     /protein_start="682"
                     /score="41.2"
                     /tool="antismash"
                     /translation="GVRPDAIVGHSTGEVAAFYEAGVYDLADAVKVVFHRS"
     CDS_motif       6506..6553
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0008"
                     /evalue="3.30E-03"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="cftB"
                     /protein_end="852"
                     /protein_start="836"
                     /score="10.2"
                     /tool="antismash"
                     /translation="LDAGYWWHNVRDSVRF"
     CDS_motif       6539..6661
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0009"
                     /evalue="9.90E+00"
                     /label="C2_DCL_024-062"
                     /locus_tag="cftB"
                     /protein_end="888"
                     /protein_start="847"
                     /score="-1.4"
                     /tool="antismash"
                     /translation="DSVRFRQAVERLADDGYGLFLEIGPHPVLGRSIQETVEAHP"
     aSDomain        6896..7369
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_PKS_DH.1"
                     /evalue="9.50E-36"
                     /label="cftB_PKS_DH.1"
                     /locus_tag="cftB"
                     /protein_end="1124"
                     /protein_start="966"
                     /score="115.5"
                     /tool="antismash"
                     /translation="HPLLGRRLPGAEPAWEARLDAEALPYLEDHRIQGDVVFPAAGYLE
                     MAVQAVRALTGGTDAALADIELRKALLLPDDESRAVRLTLCAEQGTFTVATGEGRERTV
                     HAVGTVRPGQRRRPGRPLDAEAVRGRALRRLAGADCYAGLAALGYHYGPAFQGI"
     CDS_motif       6971..7048
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0010"
                     /evalue="6.20E-14"
                     /label="PKSI-DH_m2"
                     /locus_tag="cftB"
                     /protein_end="1017"
                     /protein_start="991"
                     /score="44.2"
                     /tool="antismash"
                     /translation="YLEDHRIQGDVVFPAAGYLEMAVQAV"
     CDS_motif       7337..7369
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0011"
                     /evalue="7.20E-03"
                     /label="PKSI-DH_m3"
                     /locus_tag="cftB"
                     /protein_end="1124"
                     /protein_start="1113"
                     /score="9.4"
                     /tool="antismash"
                     /translation="GYHYGPAFQGI"
     aSDomain        8498..9076
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_PKS_KR.1"
                     /evalue="4.30E-58"
                     /label="cftB_PKS_KR.1"
                     /locus_tag="cftB"
                     /protein_end="1693"
                     /protein_start="1500"
                     /score="188.1"
                     /tool="antismash"
                     /translation="GAYLVTGAFGALGQLLCRTLVKRGARRLILVGRSTPPPRESWRAL
                     DPESRDGQRAAFLRELEELGAEVVPAALDVTDEPALAAWLAEYRRLDRPPVRGVFHLAG
                     QVRDTLVGELDRSAFDTVYGPKVLGALALHRQLAGEPLDHFVLFASIASLLTTAGQTNY
                     AAGNAFLDALAHHRRALGLPALSLDWGPWA"
     CDS_motif       8501..8599
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0012"
                     /evalue="1.90E-13"
                     /label="PKSI-KR_m1"
                     /locus_tag="cftB"
                     /protein_end="1534"
                     /protein_start="1501"
                     /score="42.9"
                     /tool="antismash"
                     /translation="AYLVTGAFGALGQLLCRTLVKRGARRLILVGRS"
     CDS_motif       8921..9031
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0013"
                     /evalue="6.20E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="cftB"
                     /protein_end="1678"
                     /protein_start="1641"
                     /score="67.0"
                     /tool="antismash"
                     /translation="LDHFVLFASIASLLTTAGQTNYAAGNAFLDALAHHRR"
     aSDomain        9338..9586
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_PKS_PP.1"
                     /evalue="3.40E-16"
                     /label="cftB_PKS_PP.1"
                     /locus_tag="cftB"
                     /protein_end="1863"
                     /protein_start="1780"
                     /score="51.3"
                     /tool="antismash"
                     /translation="RTAGEEERRALLTELFTELAATVLRVPADRVDPAAGLGGLGLDSL
                     LAMELRARLSGELGVTLPVVALLGNAPVAELVARLHES"
     aSDomain        9659..10546
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="5.50E-87"
                     /label="cftB_Condensation_LCL.1"
                     /locus_tag="cftB"
                     /protein_end="2183"
                     /protein_start="1887"
                     /score="283.4"
                     /tool="antismash"
                     /translation="AHPLTHNQKALWFLKQLNPDGFAYNIGGAVEVRVELEPELMAAAF
                     RAMVERHPSLRANFTLDAGRAVQRISAEVEPDFDVFDVEHLAWDDIHAMIVREYRRPYD
                     LERDPLVRFRLFRRGPARWVIMKAVHHIISDAISTFTFIEELLAVYEGLRRGRAPELPP
                     VAARYLDFLNRQNAFLAGREAPRMLEYWRSHLPAEVPLLSLPTDKPRPAVQTHNGASEF
                     FVLDEELSARVHALARAHNVTVFMVLLSAYYLLLHAYAGQEDIIVGSPVTGRTDEEFAG
                     VYGYFVNPLPLHVSL"
     aSModule        9659..13300
                     /complete
                     /domains="nrpspksdomains_cftB_Condensation_LCL.1"
                     /domains="nrpspksdomains_cftB_AMP-binding.1"
                     /domains="nrpspksdomains_cftB_PP-binding.1"
                     /domains="nrpspksdomains_cftB_Thioesterase.1"
                     /final_module
                     /locus_tags="cftB"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       9725..9835
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0014"
                     /evalue="2.10E-11"
                     /label="C2_LCL_024-062"
                     /locus_tag="cftB"
                     /protein_end="1946"
                     /protein_start="1909"
                     /score="36.2"
                     /tool="antismash"
                     /translation="AYNIGGAVEVRVELEPELMAAAFRAMVERHPSLRANF"
     CDS_motif       10043..10108
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0015"
                     /evalue="7.10E-06"
                     /label="C3_LCL_132-143"
                     /locus_tag="cftB"
                     /protein_end="2037"
                     /protein_start="2015"
                     /score="18.7"
                     /tool="antismash"
                     /translation="VHHIISDAISTFTFIEELLAVY"
     CDS_motif       10448..10534
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0016"
                     /evalue="3.20E-11"
                     /label="C5_LCL_267-296"
                     /locus_tag="cftB"
                     /protein_end="2179"
                     /protein_start="2150"
                     /score="35.6"
                     /tool="antismash"
                     /translation="DIIVGSPVTGRTDEEFAGVYGYFVNPLPL"
     CDS_motif       10586..10705
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0017"
                     /evalue="2.40E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="cftB"
                     /protein_end="2236"
                     /protein_start="2196"
                     /score="52.0"
                     /tool="antismash"
                     /translation="RTTVLGGLDHQEYPFVLLVEQLGLQHDPSRSAVFQAMFIL"
     aSDomain        11054..12301
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_AMP-binding.1"
                     /evalue="1.90E-96"
                     /label="cftB_AMP-binding.1"
                     /locus_tag="cftB"
                     /protein_end="2768"
                     /protein_start="2352"
                     /score="315.0"
                     /tool="antismash"
                     /translation="RAAAADPAAPAVAVPAESGPTVRLTYGELAGRSRRAAVRLRALGA
                     GPGTVVALCLEKSPELIVALLAVLRTGAAYLPLDPGHPVERLAYLVGHTGAGLLVGDDR
                     ERLGGLPARLVTTAELGADGTTGADDPDGEGFADVPVGLDDPAYVIHTSGSTGRPKAVR
                     VSHGNLASAYRAWQSEYRLDTDARTHLQMAGPAFDVFTGDVVRALCSGGTLVLVGRELL
                     FNTARLYEVMRTERVDAAEFVPAVVRTVLDHCERTGQDLAFMRLLVVGSDVWKVEEYRR
                     LGALCGPRTRLVNSYGLTETTIDSAYFEGPTDGLEPSRMVPIGRPFPNSAFHLLDAQGR
                     PVPPGVTGELWIGGSGVALGYLGDEEQTARRFATLPLGGADGTEPVRLYRTGDLARWDA
                     DGGVHLLGRADSQIKVR"
     CDS_motif       11249..11290
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0018"
                     /evalue="2.80E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="cftB"
                     /protein_end="2431"
                     /protein_start="2417"
                     /score="14.3"
                     /tool="antismash"
                     /translation="LAVLRTGAAYLPLD"
     CDS_motif       11492..11551
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0019"
                     /evalue="5.10E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="cftB"
                     /protein_end="2518"
                     /protein_start="2498"
                     /score="25.2"
                     /tool="antismash"
                     /translation="AYVIHTSGSTGRPKAVRVSH"
     CDS_motif       12080..12169
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0020"
                     /evalue="3.80E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="cftB"
                     /protein_end="2724"
                     /protein_start="2694"
                     /score="48.0"
                     /tool="antismash"
                     /translation="PPGVTGELWIGGSGVALGYLGDEEQTARRF"
     CDS_motif       12269..12331
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0021"
                     /evalue="6.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="cftB"
                     /protein_end="2778"
                     /protein_start="2757"
                     /score="34.3"
                     /tool="antismash"
                     /translation="LGRADSQIKVRGHRIELGEIE"
     aSDomain        12635..12817
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_PP-binding.1"
                     /evalue="8.70E-13"
                     /label="cftB_PP-binding.1"
                     /locus_tag="cftB"
                     /protein_end="2940"
                     /protein_start="2879"
                     /score="40.5"
                     /tool="antismash"
                     /translation="AEHWRTLLGIEEPGLQHDFFESGGSSIRLIELIHGLQAEFNISIP
                     VSQLFKVTTLHGMAKT"
     aSDomain        12887..13300
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftB_Thioesterase.1"
                     /evalue="1.60E-29"
                     /label="cftB_Thioesterase.1"
                     /locus_tag="cftB"
                     /protein_end="3101"
                     /protein_start="2963"
                     /score="95.8"
                     /tool="antismash"
                     /translation="QTLFCFPPAGGHGLVYRQFAAHLPEYRTIAFNYVSGDDKVDQYAD
                     LVEALQPEGPCALLGYSLGGNLAFEVAKELERRGRAVPNVVIMDSHRIPESFDLADEHL
                     QAFETELAEHLHRHTGSAAVARETREQARDYLRF"
     CDS_motif       12890..12919
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0022"
                     /evalue="1.40E-02"
                     /label="NRPS-beforete1"
                     /locus_tag="cftB"
                     /protein_end="2974"
                     /protein_start="2964"
                     /score="8.6"
                     /tool="antismash"
                     /translation="TLFCFPPAGG"
     CDS_motif       13037..13111
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_cftB_0023"
                     /evalue="6.30E-12"
                     /label="NRPS-te1"
                     /locus_tag="cftB"
                     /protein_end="3038"
                     /protein_start="3013"
                     /score="37.8"
                     /tool="antismash"
                     /translation="QPEGPCALLGYSLGGNLAFEVAKEL"
     gene            13530..14789
                     /gene="cftA"
     CDS             13530..14789
                     /codon_start=1
                     /gene="cftA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 436.8; E-value:
                     1.2e-132)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450"
                     /protein_id="QWM97863.1"
                     /sec_met_domain="p450 (E-value: 3.8e-25, bitscore: 77.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPETAPGRAPSLPAPARETEATMLRQHPPLTYPFEPNGLELDPR
                     YAELRDQPLVRIRMPYGDGAWLATRYEDVRAVLADPRFSLAAAMGEDQPRMRPVSRTGA
                     GLFSTEPPEHTRLRSLVAKEFSARRVERLRIRAAELADELLDGMLAAGAPADLVEDFAI
                     PMPTTIICEVLGIPAEDHRMLWEWAETVLSAVTPGEVLAVEGRAFIDYMAGVLELRGRE
                     PGEDLLTTLVRACREQRLIGEEELLSIACDLLIAGFVSTTNQIGNFFHQLLVNPEELAR
                     LRERPELIPRAVEELMRYVPLLTGFSLPRYATADVELGGVVIRAGEAVMIATAAANRDP
                     EVFEEPERLVLDRPGNPHIGFGHGVHYCIGAHLARLELQVAIERVLTRLPGLRLAVPER
                     ELRWKEASMVNGLQALPIAW"
     gene            14876..16702
                     /gene="cftC"
     CDS             14876..16702
                     /codon_start=1
                     /gene="cftC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 517.2; E-value: 9e-157)"
                     /gene_kind="biosynthetic-additional"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="QWM97864.1"
                     /transl_table=11
                     /translation="MARQKDTAPRRESMIVIGGGLGGLSTGCYARMNGYRTRIFEMHEI
                     PGGSCTGWDRSDFTFDWCISWLLGNGPGNEMYQIWLELGALQGKEMRHFDVFNIVRGRD
                     GREVRFYSDPDRLEAHLLGLSPADAAPIREFCAGIRTFRKALAAYPFLKPVGLMGRLER
                     WRMLASFVPHFNTIRKSITLLMTDFSQRFRDPLLREAFNFILYEKHPAFPVLPFYFQLA
                     SHANHAAGVPEGGSLALARSIEERYLGLGGEITYNAKVEEILVERDRAVGVRLSDGREF
                     RADIVVSAADGHTTVMKLLKGQYLNDTYRRLYTSLIDEPGQLSPGYVSLFLGLRKPFPE
                     GDPCTTHLLGERETAELTGIRCPSVNVQFRTRHYPELAPENSTVVFATYFSDIAPWRAL
                     HEGPEQSSRVRRGEELHTLPVKHGREYMAAKRRVRNGIVGFLDERYPGFKDAVAVADVS
                     TPLTQVRYTGVYDGTFPGWNPFVEGAETVEEEIKKSGPVLPGLSNFYLSGVWATIGGLI
                     RAAAAGRHVMQFVCRDDGIEFTAGIDPSAPMPTHLVIPVGRPAEPGRRTVPPANKPASK
                     AASKAASGKSGKGGKSDENSEDSENVQTGALA"
     gene            16699..17757
                     /gene="cftD"
     CDS             16699..17757
                     /NRPS_PKS="Domain: PKS_ER (31-350). E-value: 1e-15. Score:
                     49.5. Matches aSDomain: nrpspksdomains_cftD_PKS_ER.1"
                     /codon_start=1
                     /gene="cftD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 120; E-value: 1.9e-36)"
                     /gene_kind="biosynthetic-additional"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="QWM97865.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.2e-17, bitscore:
                     53.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIEKWVVREHLDGVPDVNRVYEKVVEDVRIDLRPDEMLFRTRYV
                     SVDPYQNGLALETPIGHHMGADSIMEVVEAGPAAAFAVGDLVQGFGGWRTHVVHNGAEE
                     LWTTGIFPMVFPAYRRLDPSWYGERLPVSTALGIMGAPGMTAWGTLTRFLEVRPGDTVV
                     VSGASGSIGTLVGQLAKRAGAGRVVGTTGSPGKAEYLRELGFDEVVLYTQGDDAEKVRQ
                     ALLLAAPDGVDRYFDNLGGTVTDAVFTMLNVDSRVAVCWQWATTVNGELTGPRLLPYIM
                     FPRTTIRGIFAQEWFTEPLLAQMHQELGGLVRDGEIRYHQTVHKGFDEIPAAYRSLYLD
                     REHNRGKVLVEV"
     aSDomain        16792..17748
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_cftD_PKS_ER.1"
                     /evalue="1.00E-15"
                     /label="cftD_PKS_ER.1"
                     /locus_tag="cftD"
                     /protein_end="350"
                     /protein_start="31"
                     /score="49.5"
                     /tool="antismash"
                     /translation="DLRPDEMLFRTRYVSVDPYQNGLALETPIGHHMGADSIMEVVEAG
                     PAAAFAVGDLVQGFGGWRTHVVHNGAEELWTTGIFPMVFPAYRRLDPSWYGERLPVSTA
                     LGIMGAPGMTAWGTLTRFLEVRPGDTVVVSGASGSIGTLVGQLAKRAGAGRVVGTTGSP
                     GKAEYLRELGFDEVVLYTQGDDAEKVRQALLLAAPDGVDRYFDNLGGTVTDAVFTMLNV
                     DSRVAVCWQWATTVNGELTGPRLLPYIMFPRTTIRGIFAQEWFTEPLLAQMHQELGGLV
                     RDGEIRYHQTVHKGFDEIPAAYRSLYLDREHNRGKVLV"
     CDS             complement(17836..18417)
                     /codon_start=1
                     /product="TrmH family RNA methyltransferase"
                     /protein_id="QWM97866.1"
                     /transl_table=11
                     /translation="MKQLRGTELKRLHRSWRRGNEFRLAMILENLQSPFNVGSVVRTGA
                     AMGAEKLYLTGDTPSVRSSGAQKAAMGTDKYLKVEHFPTVAEAVAAAKADGFKVVGLEL
                     ADEAVPMFAAELTPAVAFVLGHEDRGITADALALCDQVVFVPQLGRVGSLNVSAAATVA
                     CYEARRQGYAISGTPDGSDAGGFDIDLDDE"
     CDS             complement(18414..19058)
                     /codon_start=1
                     /product="methyltransferase domain-containing protein"
                     /protein_id="QWM97867.1"
                     /transl_table=11
                     /translation="MSGSHYFSGAPEVASERRPITVTLPDLTLELSTDAGVFSRSRLDP
                     GTRILLEQAPPPRVRGPILDIGCGYGPIALTWASRRKRLPVWAVDVNGRALDLVRDNAE
                     SLGLGNVHAALPEEVPAELRFAAIYSNPPIRIGKAALRRLLEQWLDRLTPDGSAFLVVQ
                     KHLGSDSLQKWLNEHGWPTTRLTSVNGFRILEARPRPTAGEGPESGRGTTS"
ORIGIN
        1 ctaccgcccg gcagtctggt ggcggttcgg acctggggcc tcgaggaccg ctggcgactg
       61 gtcgtccggt gaccccgccc gctccggccg gcgccgcagc agcaccgcga ccagcgcggc
      121 gcccgccagg gcggtgaggc cggcggccag cagggtgcgg tcgaggccgg tggcgaaggc
      181 ggtccggagc agttcccctg gcagcccggc cgggggccgg ccggacgcca gcgcgccggc
      241 ggtggcgtcc gggtcgggcc cggccgccgg gtggccggcc agggcgtcgc gcaggccccc
      301 gtgcaggacc agcccgagga cggcgatgcc cagcgcctgg ccgagctgcc ggaaggtgtt
      361 gagggcgccg ccggccatgc cgccgcgctc gggcgggacg gccgccatcg cggcggacgc
      421 caggaccggg ctgaccgcgc cgatgccgag gccggtcagg gcgaggccgg gcagtagggc
      481 ggtccagccg gaggagccgt ccagggcgcc ctgcagcagg gtgcccagcc cgatcacggc
      541 caggccgccc gccagcggca ccgcgaccgg cagcgcggcg agccgacggc ccgccagcgc
      601 cgggacggcg aaggcgacga cgctcatcgg cagcagggtc agcccggcgg ccatcgggcc
      661 gaggccgagc accgactgca gccagagcga gatgtagggc aggccggaga aggcggtggc
      721 cgagtagacg gcgccgcaca gcaggacccc ggtgaaggcc ggtcggcgca gcagagcggg
      781 cgccagcagc gggtgcgcgc tgagccgttc gaccagcgcg aacacggcga gcgccacgac
      841 cgcggcggta ccggcgccca ggacggcggg cgaggtccag ccgtccgtcc cgccccggat
      901 cagccccagc acggccgccc cggccgcgac ggtgaaggac gcggcgccgg gcaggtcgag
      961 ccggcgggct cccgggtcgc gggactccgg cagtgtccgc cgggccagca ccacggcggc
     1021 gagcgcgagc ggcaggttca ccaggaagat cgaccgccag cccaggtact cggtgagcag
     1081 gccgccggcc accggcccga cggccgccgc cgcgccgctg acggagcccc agacgccgaa
     1141 ggccaccgcc cggtcacggc cccggtagga gaggttgagc agcgccatcg cggtggcgaa
     1201 catcgccgca ccgccgcccg cctggacgat ccgggctccc accagggtgg cgccgtccgg
     1261 ggcgaggccg caggccagcg aggcgagcgc gaacaccgcc aggcccaccg tgtacacccg
     1321 ccgccggccc acccggtcgg cgagggcgcc gaggccgagc agcagcgcgg ccagtgccag
     1381 cgcgtagccg tcgagcaccc actgcagtcc gtcgaagtcc atgtccagcc ccgcgccgat
     1441 gtccggcagg gccacgatca cgatgctgac gtccgtcagc agcatgaaca ccccgaggca
     1501 gaccgccacc agcggtcccc atgtgcgcat ccccgttccc cctcgtccag gcccggccac
     1561 tgcggccggg cgccccgtca ctctcggtcc ggcggccgct cccgcgccgc tcgcaggggc
     1621 ctttccggcg gatctcgaca ccgcctacca tccggctggt ggaaaccgtg acgctggacg
     1681 gactggaccg ggcgctgctg cacgccctgc acgtggacgg ccgggcgccg ttccggcgga
     1741 tcgccgaggt gctgggggtg tccgaccaga cggtcgcccg ccgctaccag cggctgcgcg
     1801 ccgccggggt ggtgcgggtg gtggggcgga ccgacgcccg gctgctcggc caggtcgact
     1861 ggctgacccg gatccggtgc gtgcccgacg ccgccgcccc gctcgccgag gcgctggccc
     1921 ggcggccgga cacctcctgg gtgagtctgc tgtccggcgg cgagatcgtc tgcaacgccc
     1981 gcgcacggct gcggccggag cgcgaggaac tgctgctcgg cgccctgccc cggagcccgc
     2041 gggtgctgtc ggtctccgcg cactacctgc tgcgcaccta cgtcggcggc caggtggcgt
     2101 ggagcgggcg gacctcggcg ctgaccgacg ggcagatcgc ccggctccgg gccgcggcgg
     2161 ggaccgggcc gacggcggcg aaggccccgg gcctcccgca tgtcccgggc gttcctgacg
     2221 ttccggatgt tcctgacgtg ctggacgtgc tggacgtgct ggaccgggcg ctgctggcgg
     2281 cgctcgcggt ggacgggcgg gccccgctgg ccgcgctggc ggccgcgtcc gggagcccgg
     2341 agacgacggt gcgccggcgg ctggccgcgc tggtcgacgg cgggctgctc ttcttcgacg
     2401 tggacgtcga tccccgtccg ctcggcttcg aggtggaggc gttctgctgg ctgacggtgg
     2461 cgccggggcg gctggcggcg gtcggccggg cgatggcgga gcacccggag gtgggcttcg
     2521 tggcggcgac caccgggccg agcaacctgg tggcggggct ggtctgccgg gacaccgggg
     2581 cgttctacga ctacctgacc caggggctgg gcgagctgga gggggtggtc gcggtggaga
     2641 cggctccgct gctccggagc gtcaaacgtg ccgggatgat catgccgtca tcgaataatc
     2701 cgtaaaagct cgccgctggc cggattctcg cggcttctgg ctaattattt gtctacagat
     2761 catcagacaa atcgagaatt ccatgattcc cctcgaaaat gcctcgccat gacttcggac
     2821 cgcccttagt atctgaacga acacttttgg tgactgttcg accgcggaca gcgaaggggg
     2881 tcgtcatggg caagcggctt cgaaccgtgc tgcgccacgt cgcctacccg ttcctgctgg
     2941 tcaccctggt ggggatagcc gtcgcggccc tgcgtctgcg ctgggacctc gaccgggtga
     3001 accagctgtt cctgctcggc gtgatcgctt tcatgtccct gctcgaacgt ttgattccgt
     3061 acgaaccgga atggtctccg agcgtgcgcg agtggggctg gtacggcgtc tacttcctgc
     3121 tgacgatgat cggcggggca ctctcccagg tgcccgtggc cgccctcgtc ggctggttgg
     3181 ccccgccccg gtcggcgctg ccgccgtggg tggagatccc ggccgccctg ctgctcggat
     3241 cgctggccaa ctacctggtc caccgctggt gccacaccag tccgcggctc tggcggctgc
     3301 acggcgtcca ccacgtgccc gacaaggtga acgtcggcaa caacggggtg aaccacctgt
     3361 tggacgtgct gctcacccag ggcgccgtcc agctggcgct ggccgcggcc gggttctcgg
     3421 cgccgacggt gttcgtggtc ggcctgttcg tcgtcgccca gggctacttc gtgcacgcca
     3481 acatcgacgt ccggatcggc ccgctcaatt atgtgctcgc cggtcccgag cagcaccgcc
     3541 tgcaccacag caccgatctg gcggaggccg ggcactacgg ctccgacctg tcggtgtggg
     3601 accacgtgtt cggcagcttc acctggcggc ccggccgccg gccgctcgcg gtggggctgg
     3661 cgaatccggc cgacttcccg gccaccggcc gggtggtcgc cagccacctc caggcctggc
     3721 accgccccgc ccgggccgag cgctccccga ccggcaccac ctgagccgcg cccgccgtcc
     3781 cgtccccgcc gtcccgtccc cgccctgccc cgccgtcccg ccccagccct gtcccaccgg
     3841 cccgtcccca ccgctcctcc cgaccggctc gccccttcgg ccgacccggc ttccggcctg
     3901 cccggaaccc ggcgcgcggc cgctgtcccc cggcgcgcgc ggcgctcccg cagcccgcca
     3961 gcgcgcgcga acgcagcgac ccaaggactc gactcgtatg acggattccc gcttcgtcac
     4021 ctccccggac ctccccgaac cctccgaacg ccccgtcccc ggcggcccgc ccgccgcgcc
     4081 gggcgccggt cgggagaaga tcgcgatcat cgggatcggc tgccgcctgc caggcggggc
     4141 cagcgaccac cgcacctact ggcagaacct cctcgacggc aaggactgca tcaccccgac
     4201 cccgcgcagc cgctacgacg tcgccaccct cggcagccgg gacaaggcca agcccggccg
     4261 gctggtcggc ggccgcggcg gctacatcga cggcttcgac gagttcgacc cggcgttctt
     4321 cggcatcagc ggccgcgagg ccgaccacat ggacccgcag cagcggaaac tgctggaggt
     4381 ggcctgggag gcgctggagg acggcgggca gaagccggcc gaactggcgg gccgtgaggt
     4441 cggcgtctac gtcggagcgt tcaccctgga ctacaagatc gtccagttct cggacctctc
     4501 cttcgacacc ctcgccgcgc acaccgccac cggcaccatg atgacgatgg tgtcgaaccg
     4561 catctcgcac tgcttcgact tccgcggccc cagcgtctcc ctcgacaccg cctgctcctc
     4621 ctccctggtc gccgtccacc tcgccgtgca gagcctgcag cgcggcgaga ccgacctcgc
     4681 cctggccggc ggcaccctgc tgcacatcgc cccgcagtac acgatcgcgg agaccaaggg
     4741 cggcttcctc tccccgcagg gccgctcccg caccttcgac gcgtcggccg acggctacgt
     4801 ccgggccgag ggcgtcgcgg tggtcgcgct caagcggctc tccgacgcgc tgcgcgacgg
     4861 cgacccggtc cacgccgtgg tcatcggcag cggtgtcaac caggacggcc gcaccaacgg
     4921 catcaccgtg cccaacccgg acgcccaggt caccctgatc gagcgggtct gcgccgaggc
     4981 cgggatcgtc cccggcagcc tccagtacgt cgaggcgcac ggcacctcga ccccggtcgg
     5041 cgacccgatc gaggcgggcg ccctggcccg ggccctcgcc gtcgggcgcc gtcccggcga
     5101 caagtgctac gtcggctcgg tcaagaccaa catcgggcac accgagtcgg cctccgggct
     5161 ggcgggtctg atcaagtccg cgctcgccct caagcaccgg accgtgccgc cgcacatcaa
     5221 cctggagcgg ctcaacccgg cgatcgaccc ggccgccctg ccgtacgaga tccccaccga
     5281 ggtcaccccc tggccggagc acgagggccc ggcccgggcc ggggtgaact ccttcggctt
     5341 cggcggcacc aacgcccacg tcctgctgga ggccgcgccg gagccgtcac cggagctgtc
     5401 accggagctg tcaccggtgt ccgtacccgc gccggccggc gccgccgaca atgccaccgc
     5461 cgatgccggg ggcaccgggc acggaccggc cgccgggcgc ccgcgctgga cggtgctgcc
     5521 gctgaccgcc agggaggccg ccgccctgcc cgaactggcc gccggtgtcc aggccgaact
     5581 ggccggcgtc cgcggcggca gcccggcccg cccggccgac ctcggccaca ccctcgccca
     5641 ccgccgccag caccacgacg cccggctctc ggtggtctac gacgcccgcg agcacgccgc
     5701 ccgcgcctcg ctcgacgagg cgctcaccgc ccatctgcgc ggcgaaccgc acccccgggt
     5761 cctcaccggc caccgtcgcg aggcccggca ccgccggctc gcctgggtct tcaccgggat
     5821 gggcccgcag tggtgggcga tgggccgccg cctcctcgcc accgaaccgg tctaccggga
     5881 ggccgtcgag tcctgcgccg agcacctcgc cgagctggcc ggctggtccc tgatcgacga
     5941 gctcaccgcc gacgaggcgg actcccggat ggccgagacc tggctcgccc agccggccaa
     6001 cttcgccgtc cagaccggcc tggccgcgct ctggcgcagc cgtggcgtgc ggccggacgc
     6061 gatcgtcggc cactccaccg gtgaggtcgc cgccttctac gaggccgggg tctacgacct
     6121 cgccgacgcg gtcaaggtgg tgttccaccg cagccggctg cagcaggagc tggccggcac
     6181 cggcggcatg ctcgcggtct cgctcaccga ggccgaggcg ctgcgccgga tccgcccgta
     6241 cgggggcgcg gtgtcggtcg ccgccgtgaa cagccccacc gcgctcaccc tcgccgggga
     6301 cgccccggcc ctcgccgaac tggccgccgc gctcaccgcc gagcaggtct tcgcccgtcc
     6361 gctgaccgtc gaagtcccgt accacagcgc ccggatggac ctgatcaagg acgagctgct
     6421 ggagtcgctc gccgacatca aggcccgccc ggcgcagacc ccgctctacc tcaccggccg
     6481 cgagggcacc gcgcgcggca ccgagctgga cgccgggtac tggtggcaca acgtccgcga
     6541 cagcgtccgc ttccggcagg ccgtggagcg gctcgccgac gacggctacg gcctgttcct
     6601 ggagatcggc ccgcacccgg tgctcggccg ctcgatccag gagaccgtgg aggcccatcc
     6661 gggcacggcc gaccggcccg agccgcggac cctgccctcg atccgccgcc aggaggacga
     6721 acaggccacc ttcaccgcct cgctggccgc gctccacaac ctcggtgtcg aggtcgactg
     6781 gtcggtgctc cagcccgccg ggcggatcgt cccgctgccc cgctacccgt tccggcgcga
     6841 ccggcactgg gtcgagccga gggcggtcgc cgaggtccgg caggggctgg tcgaccaccc
     6901 gctgctcggc cgccggctgc ccggcgccga accggcctgg gaggcccggc tcgacgccga
     6961 ggccctgccc tacctggagg accaccggat ccagggggac gtggtgttcc cggccgcggg
     7021 ctatctggag atggccgtcc aggcggtccg cgccctcacc ggcgggacgg acgccgccct
     7081 ggccgacatc gagctgcgca aggcgctgct gctgccggac gacgagagcc gcgccgtccg
     7141 gctcaccctc tgcgccgagc agggcacctt caccgtcgcc accggcgagg gccgcgagcg
     7201 caccgtgcac gccgtcggca ccgtccgccc cggccagcgt cgccggcccg gtcggccgct
     7261 ggacgcggag gcggtccgcg ggcgggcgct gcgccggctc gccggggcgg actgctacgc
     7321 cggactcgcc gcgctcggct accactacgg ccccgccttc cagggcatcg aggaggtctg
     7381 gatcggcccc ggcgaggcac tcgcccggat ccgtccgccc gccccggtcg ccgggcaggg
     7441 cgagcggcac caggtgcacc cggtggtgat ggacgccttc ttccagaccc tgctgacgcc
     7501 ccagctgctg gccgaccggc cggcggacgc ccgggggatc cggctgccgg tggcgatcgg
     7561 ggaggtccgg ctggacgcgg tcggcgaccg cccgctctgg gtgcacgcca ccgtcacccg
     7621 ggacgccggc gccgaactcc tcggcgacct cgcggtgtac gaggagcagg gcgccccgct
     7681 cggcggggtc accggcttcc gggccgccga cgtcgaacgg gccgccaccg cggtcggcct
     7741 cggcaccatc gacggctggc tcgccgaacc ggcctgggcg gagctgccgg ccgccggcga
     7801 cgccccggac ctgctggccg agcaccccga ccactggctg ctgttcgccg acggcggcgg
     7861 ggtcgcggac accctggccg agcggatcgc cgcccgcggc ggcagctgcc tgcgggtccg
     7921 cccaggcacc ggctacctgg ccgccgccga cggccgcccg gccaccgtcg agccgggctc
     7981 ggccgcggac ctggcccggc tgctcgccga ccggcgggcc ggaggcgccc ccgacccggc
     8041 cgccgtggtc cacctgtgga acctcgaccg ccccgggctc gccaccgccg accccgccac
     8101 cgcggccggc cacaccgccc ccggcgccta cagcctggtc acgctcgccg ccctgctggc
     8161 ggccgaactc cccgactgcc ggctccatgt gatcacccgg gccgcgcagg ccgtggcccc
     8221 cggcgaagcc gtggagccgc tcgccgcccc ggcctggggc atcacccggg tgctgcggca
     8281 ccaggagctg cccacccacc agggcaaact gatcgacctc cccgccacag gcatcgaggc
     8341 ggaggccgag gcggaggccg aggccgaggc gctgctgcgc gagttcgcgc tcgccgacga
     8401 ggacgagatc gcgctgcgcg gcggccggcg gctgaccagc cggctccgga ccgccgaggg
     8461 gctcagtcgc ccgctggcgc cgcggctgcg ggcggacggc gcctacctgg tgaccggggc
     8521 gttcggggcg ctcgggcaac tgctctgccg caccctggtg aagcgcggcg cccgccggct
     8581 gatcctggtc ggccgcagca cgccgccgcc gcgcgagtcg tggcgcgcgc tcgacccgga
     8641 gagccgggac gggcagcggg cggccttcct gcgcgagctg gaggagctcg gggccgaggt
     8701 cgtcccggcc gcgctggacg tcaccgacga gcccgcgctg gccgcctggc tggccgagta
     8761 ccggcggttg gaccggccgc cggtccgggg cgtcttccac ctcgccgggc aggtcaggga
     8821 caccctggtc ggcgagctgg accggtcggc cttcgacacc gtgtacggcc ccaaggtgct
     8881 cggcgccctc gccctgcacc ggcagctggc cggggagccg ctggaccact tcgtgctgtt
     8941 cgcctcgatc gcctccctgc tgaccaccgc cggccagacc aactacgccg ccggcaacgc
     9001 cttcctggac gccctcgccc atcaccgccg ggcgctcggc ctgcccgcgc tcagcctgga
     9061 ctggggcccc tgggccaccg ggatgatcga ggagctcggc ctgatcgacc actaccggca
     9121 cagccggggc atgagctcgc tcgccccgga gaccggtatg gccgtgctgg agcgggtgct
     9181 cggccaggac cgggcccaac tgctggtcgc caccgtggtc gactggccgg tcttcctctc
     9241 ctggtacccg gccccgccgc cgctggtgac cgaactcgcc gcagccgcac gggagtccgc
     9301 gccggccgtc gaacggaccg ggctgctgga caccctgcgg acggccggcg aggaggagcg
     9361 gcgggcactg ctcaccgagc tgttcaccga gctggccgcc accgtgctgc gggtgccggc
     9421 cgaccgggtc gacccggccg ccggtctcgg cggcctcggg ctggactcgc tgctggcgat
     9481 ggagctgcgg gcccggctga gcggcgaact cggggtcacc ctcccggtgg tggcgctgct
     9541 cgggaacgcc ccggtggccg agctggtcgc ccggctgcac gagtcgctga ccgagctgct
     9601 ggacgaggag ccggccggtc cgggggcggc gggggtggag cgctacgagg acgagtccgc
     9661 gcacccgctg acgcacaacc agaaggcgct ctggttcctc aagcagctca acccggacgg
     9721 cttcgcctac aacatcggcg gcgcggtcga ggtgcgggtg gagctggagc ccgagctgat
     9781 ggcggcggcc ttccgggcga tggtcgagcg ccacccgagc ctgcgggcga acttcacgct
     9841 cgacgccggc cgggcggtgc agcggatctc cgccgaggtg gagccggact tcgacgtctt
     9901 cgacgtcgag cacctggcct gggacgacat ccacgcgatg atcgtccgcg agtaccgccg
     9961 accgtacgac ctggagcggg acccgctggt gcggttccgg ctgttccggc gcggcccggc
    10021 ccgctgggtg atcatgaagg ccgtccacca catcatctcg gacgcgatct ccaccttcac
    10081 cttcatcgag gagctgctgg ccgtctacga ggggctgcgc cggggccggg cgcccgagct
    10141 gcccccggtc gccgcccgct acctggactt cctcaaccgg cagaacgcct tcctggccgg
    10201 ccgcgaggcg ccgaggatgc tggagtactg gcgctcccac ctgccggccg aggtgccgct
    10261 gctcagcctg ccgaccgaca agccccggcc ggcggtgcag acccacaacg gcgcctccga
    10321 gttcttcgtc ctggacgagg agctcagcgc ccgggtccac gcgctggccc gcgcgcacaa
    10381 cgtcaccgtc ttcatggtgc tgctcagcgc ctactacctg ctgctgcacg cctacgcggg
    10441 ccaggaggac atcatcgtcg gcagcccggt gacgggccgt accgacgagg agttcgccgg
    10501 cgtctacggc tacttcgtca acccgctgcc gctgcacgtc tcgctggctg gcgggccgac
    10561 cgtggccgag ctgctggagc gggtgcggac caccgtgctc ggcgggctgg accaccagga
    10621 gtacccgttc gtgctgctgg tggagcagct cgggctgcag cacgacccga gccgctcggc
    10681 ggtcttccag gcgatgttca tcctgctgca ccacaaggtg gccaccgaga agtacgggta
    10741 ccacctcgag tacatcgaac tccccgagga ggaggggcag ttcgacctca ccctgtccgc
    10801 ctacgaggac gaggcggagc gccgcttcca ctgcgtcttc aagtacaaca ccgacctctt
    10861 cctgcccggg acgacggcgc ggatggcgcg ccactacgtc aatctgctcg acgcgctgac
    10921 cacggcgggg ccggagcggg cggccaccgg gctggagctg ctcggcgagc gggagcggtc
    10981 cgtggtgctc cgggagtgga gcggcgccga ccggcgggtg ccgttcgccg agccggtcca
    11041 cgagctggtg ctgcgcgcgg cggcggccga cccggcggcg cccgcggtgg cggtgccggc
    11101 cgagtccggc ccgaccgtcc ggctgacgta cggcgagctg gccgggcgct cccgccgggc
    11161 cgccgtgcgg ctgcgggcgc tgggcgccgg accgggcacg gtggtcgcgc tctgcctgga
    11221 gaagtcgccg gagctgatcg tggcgctgct cgcggtgctc cgcaccggcg cggcctacct
    11281 gccgctggat ccgggtcacc cggtggagcg gctggcgtac ctggtcggcc acaccggggc
    11341 cgggctgctg gtcggcgacg accgcgagcg gctcggcgga ctcccggccc ggctggtcac
    11401 caccgccgaa ctcggtgccg acggcaccac cggtgccgac gaccccgacg gcgagggctt
    11461 cgccgacgtg ccggtgggcc tcgacgaccc ggcctacgtc atccacacct ccggctccac
    11521 cggccgcccc aaggcggtgc gggtctccca cggcaacctc gcctcggcct accgggcctg
    11581 gcagtccgag taccgcctgg acaccgacgc caggacccac ctccagatgg ccggccccgc
    11641 cttcgacgtc ttcaccggcg acgtggtccg cgcgctgtgc tcgggcggca ccctggtgct
    11701 ggtcggccgg gagctgctgt tcaacaccgc ccggctgtac gaggtgatgc gcaccgagcg
    11761 ggtggacgcc gcggagttcg tcccggccgt ggtccgcacc gtgctggacc actgcgaacg
    11821 caccgggcag gacctggcgt tcatgcgact gctggtggtc ggctcggacg tctggaaggt
    11881 cgaggagtac cggcggctgg gcgccctgtg cggcccgcgg accaggctgg tcaactccta
    11941 cgggctcacc gagaccacca tcgacagcgc gtacttcgag gggccgacgg acgggctgga
    12001 gcccagccgg atggtcccga tcgggcggcc gttcccgaac agcgccttcc acctgctcga
    12061 cgcccagggc cggccggtcc cgcccggggt gaccggcgag ctgtggatcg gcggctccgg
    12121 cgtggcgctc ggctacctcg gcgacgagga gcagaccgcg cgccgcttcg ccaccctgcc
    12181 gctcggcggc gccgacggca ccgagccggt ccggctctac cgcaccgggg acctcgcccg
    12241 ctgggacgcc gacggcgggg tgcacctgct cggccgggcc gactcccaga tcaaggtgcg
    12301 cggccaccgg atcgagctgg gcgagatcga gacccggctg gccgaatggc ccgagctggc
    12361 cggggcggtg gtcaccgtcc gggcggaccg cggcggcgag cacgtgctct gcgcgtactg
    12421 cgtgcctgcg cccggccgga ccttcgacca ccgggcgctg cgccgccacc tggccgggca
    12481 gttgccgacc ttcatgatcc cgacccactt caccgaactg cccgcgctgc cgctcaccgc
    12541 caacggcaag gtggacgtgg cggcgctgcc cgagccccgc acggacgccg ccgaggccgc
    12601 cgatccgccg gtcaccctct acgaggtccg gatggccgag cactggcgca ccctgctcgg
    12661 catcgaggag cccggcctcc agcacgactt cttcgagtcg ggcggctcct cgatcagact
    12721 gatcgagctg atccacgggc tgcaggccga gttcaacatc agcatcccgg tgagccagct
    12781 gttcaaggtc accaccctgc acgggatggc gaagaccgtg gagcacatca tcaccggccg
    12841 gatcgagggc gcccagccct acctgggctt caaccaggag cagcggcaga cgctgttctg
    12901 cttcccgccc gccggcggcc acgggctggt gtaccggcag ttcgccgcgc acctgccgga
    12961 gtaccgcacg atcgccttca actacgtgtc cggggacgac aaggtcgacc agtacgccga
    13021 cctggtcgag gcgctccagc cggagggccc gtgcgcgctg ctgggctact cgctcggcgg
    13081 caacctcgcc ttcgaggtcg ccaaggagct ggagcggcgc ggccgcgcgg tgcccaatgt
    13141 ggtgatcatg gactcgcacc ggatcccgga gtccttcgac ctcgccgacg agcacctcca
    13201 ggccttcgag accgagctcg ccgagcacct gcaccggcac accggctccg ccgccgtcgc
    13261 ccgggagacc cgcgaacagg ctcgggacta cctgcggttc tgcagccgca cccccaacca
    13321 cggggtggtc gccgccgcgc tcagcgtgat ctccgacgac gagaaggtcg cgctgtacga
    13381 ggccggccgg gacggcgcct ggcacggcag ctcggccacc cggacggcgg tcttcaaggg
    13441 cttcggcacc cacgccgaga tgctcgaccg cgagttcatc gcccacaacg ccgggctcgc
    13501 ccggtcgatc ctcaccggag ccgccaccca tgcgtcctga gacggccccc gggcgggccc
    13561 cgagcctgcc cgcccccgca cgagagacgg aagcgaccat gctccggcag cacccgccgc
    13621 tgacctaccc gttcgagccc aacggcctcg aactcgaccc ccgctacgcc gagttgcggg
    13681 accagccgct ggtccggatc cggatgccgt acggcgacgg cgcctggctg gccacccggt
    13741 acgaggacgt ccgggcggtg ctcgccgacc cgaggttcag cctggccgcc gcgatgggcg
    13801 aggaccagcc ccggatgcgc ccggtgtccc gcaccggcgc cggcctgttc tccaccgaac
    13861 cgcccgagca cacccggctg cgctcgctgg tggccaagga gttcagcgcc cgccgggtgg
    13921 agcggctgcg gatccgggcc gcggagctgg ccgacgagct gctcgacggc atgctcgccg
    13981 cgggcgcccc ggccgacctg gtcgaggact tcgcgatccc gatgccgacc accatcatct
    14041 gcgaggtgct cggcatcccc gccgaggacc accggatgct ctgggagtgg gcggagacgg
    14101 tgctctccgc cgtcaccccg ggcgaggtgc tcgcggtcga ggggcgggcg ttcatcgact
    14161 acatggccgg ggtgctggag ctgcgcggcc gcgagcccgg cgaggacctc ctcaccacgc
    14221 tggtccgggc ctgccgcgag cagcggctga tcggcgagga ggagctcctc tccatcgcct
    14281 gcgacctgct gatcgccggc ttcgtctcca ccaccaacca gatcggcaac ttcttccacc
    14341 agctgctggt caaccccgag gagctggcac ggctgcggga gcggcccgag ctgatcccca
    14401 gggcggtcga ggagctgatg cggtacgtgc cgctgctcac cggcttcagt ctgccccggt
    14461 acgccaccgc ggacgtcgag ctgggcgggg tggtgatccg ggccggcgag gcggtgatga
    14521 tcgcgaccgc cgccgccaac cgggacccgg aggtgttcga ggagccggag cggctggtcc
    14581 tcgaccggcc gggcaacccg cacatcggct tcggccacgg cgtgcactac tgcatcggcg
    14641 cgcacctggc ccggctggag ctgcaggtgg cgatcgagcg ggtgctgacc cgcctgcccg
    14701 gcctgcggct ggccgtcccc gagcgcgaac tgcgctggaa ggaggcctcg atggtgaacg
    14761 gtctgcaggc gctcccgatc gcctggtgac cgccgtcgcg ggcggcccga ccgggccacc
    14821 gccaggcacc gccaggcacc accaggcaag gcaaggacca cgaggaaggc cagagatggc
    14881 acggcagaaa gacaccgcac cccggcggga gtcgatgatc gtcatcggcg gcggtctcgg
    14941 cggactgtcc accgggtgct acgcccggat gaacggctac cgcaccagga tcttcgagat
    15001 gcacgagatc cccggcggct cctgcaccgg ctgggaccgc agcgacttca ccttcgactg
    15061 gtgcatcagc tggctgctcg gcaacggccc gggcaacgag atgtaccaga tctggctcga
    15121 actgggcgcg ctccagggca aggagatgcg gcacttcgac gtcttcaaca tcgtccgggg
    15181 ccgggacggc cgggaggtcc gcttctactc cgatccggac cggctggagg cgcacctgct
    15241 cggcctctcg ccggccgacg ccgccccgat ccgcgagttc tgcgccggga tccgcacctt
    15301 ccgcaaggcg ctcgcggcct atccgttcct caagccggtc gggctgatgg gccggctgga
    15361 gcgctggcgg atgctggcct ccttcgtccc ccacttcaac accatccgca agtcgatcac
    15421 gctgctgatg acggacttct cgcagcggtt ccgcgacccg ctgctgcgcg aggcgttcaa
    15481 cttcatcctc tacgagaagc acccggcctt cccggtgctg ccgttctact tccagctcgc
    15541 ctcgcacgcc aaccacgccg ccggggtgcc ggagggcggt tcgctcgcgc tggcccggtc
    15601 gatcgaggag cgctacctcg gtctcggtgg cgagatcacc tacaacgcca aggtcgagga
    15661 gatcctggtc gagcgggacc gcgcggtggg tgtgcggctc agcgacggcc gggagttccg
    15721 cgccgacatc gtggtgtccg ccgccgacgg ccacaccacc gtgatgaagc tgctcaaggg
    15781 ccagtacctc aacgacacct accggcggct ctacacctcg ctgatcgacg agccgggcca
    15841 gctgtcgccc gggtacgtgt cgctctttct ggggctgcgc aagcccttcc ccgagggcga
    15901 cccgtgcacc acccacctgc tgggcgagcg ggagacggcg gagctgaccg ggatccgctg
    15961 cccctcggtg aacgtgcagt tccgcacccg gcactacccg gagctggcgc cggagaactc
    16021 caccgtggtg ttcgcgacgt acttctccga catcgccccc tggcgggcgc tgcacgaggg
    16081 ccccgagcag tcctcccggg tgcggcgcgg cgaggagctg cacaccctgc cggtcaagca
    16141 cggccgggag tacatggcgg ccaaacggcg ggtccgcaac ggcatcgtcg gcttcctgga
    16201 cgagcgctac ccgggcttca aggacgcggt ggccgtcgcc gacgtgtcca ccccgctgac
    16261 ccaggtccgc tacacgggcg tctacgacgg caccttcccc ggctggaacc ccttcgtgga
    16321 gggcgccgag acggtggagg aggagatcaa gaagagcggc ccggtgctgc ccgggctgtc
    16381 gaacttctac ctctccgggg tctgggcgac catcggcggg ctgatccggg cggccgccgc
    16441 cggacggcac gtcatgcagt tcgtctgccg ggacgacggg atcgagttca ccgccgggat
    16501 cgacccgagc gccccgatgc cgacccacct ggtgatcccg gtggggcggc ccgcggagcc
    16561 gggccggcgg acggtgccgc ccgcgaacaa gcctgcgagc aaggccgcga gcaaggccgc
    16621 gagcggcaag agcggcaagg gcggcaagag cgacgagaac agcgaggaca gcgagaacgt
    16681 gcagacggga gccctggcat gaggatcgag aagtgggtgg tccgggagca cctggacggt
    16741 gtgcccgacg tcaaccgggt ctacgagaag gtcgtggagg acgtccggat cgacctgcgg
    16801 ccggacgaga tgctcttccg gaccaggtac gtctcggtgg acccgtacca gaacggcctg
    16861 gcgctggaga cgccgatcgg ccaccacatg ggcgccgact cgatcatgga ggtggtcgag
    16921 gccggtccgg cggcggcgtt cgcggtcggc gacctggtgc agggcttcgg cggctggcgc
    16981 acccacgtcg tccacaacgg cgccgaggag ctgtggacga ccggcatctt cccgatggtg
    17041 ttcccggcct accgccggct cgacccgtcc tggtacggcg agcggctgcc ggtctccacg
    17101 gcgctcggca tcatgggcgc gcccgggatg acggcctggg gcacgctcac ccgcttcctg
    17161 gaggtccggc ccggcgacac cgtggtggtc agcggcgcct ccggctcgat cggcaccctg
    17221 gtgggccagt tggcgaagcg ggccggggcc ggccgggtgg tcggcaccac cggttcgccg
    17281 ggcaaggccg agtacctgcg cgagctgggc ttcgacgagg tggtgctcta cacccagggc
    17341 gacgacgcgg agaaggtccg gcaggcgctg ctgctggcgg cgccggacgg cgtcgaccgg
    17401 tacttcgaca acctgggcgg cacggtcacc gacgcggtgt tcacgatgct gaacgtggac
    17461 agccgggtgg cggtctgctg gcagtgggcg accacggtga acggtgagct gaccgggccg
    17521 aggctgctgc cgtacatcat gttcccgcgc accacgatcc gcggcatctt cgcccaggag
    17581 tggttcaccg agccgctgtt ggcgcagatg caccaggagc tgggcgggct ggtccgggac
    17641 ggggagatcc gctaccacca gaccgtgcac aagggcttcg acgagatccc ggcggcctac
    17701 cgcagcctct acctggaccg cgagcacaac cggggcaagg tgctggtcga ggtctgaccc
    17761 ggccgggacc cgccggggct cccgggatcc gagccggtcc gccggcggga ggggtgccct
    17821 cccgccggcg gcggatcact cgtcgtcgag gtcgatgtcg aagccgccgg cgtccgagcc
    17881 gtccggggtg ccgctgatcg cgtacccctg gcggcgcgcc tcgtagcagg ccaccgtggc
    17941 ggcggcggag acgttcagcg agccgacccg gcccagctgg ggcacgaaca ccacctggtc
    18001 gcagagggcg agcgcgtccg ccgtgatgcc gcggtcctcg tggcccagca cgaaggcgac
    18061 ggccggggtc agctcggcgg cgaacatcgg caccgcctcg tcggccagtt cgaggccgac
    18121 caccttgaag ccgtcggcct tcgccgcggc caccgcctcg gcgacggtgg ggaagtgctc
    18181 caccttcagg tacttgtcgg tgcccatcgc ggccttctgc gcgccggagg agcgcaccga
    18241 cggggtgtca ccggtgaggt agagcttctc cgcgcccatc gcggcgccgg tccggaccac
    18301 cgagccgacg ttgaacggcg actggaggtt ctccaggatc atcgcgagcc ggaactcgtt
    18361 gccacgccgc caggagcggt gcagccgctt cagttcggtc ccgcggagct gcttcacgac
    18421 gtcgtccctc gtccactctc ggggccctcg cccgccgtcg ggcggggccg cgcttccaga
    18481 atccggaacc cgttgaccga ggtcagccgg gtggtcggcc agccgtgctc gttcagccac
    18541 ttctgcagcg agtccgagcc gaggtgcttc tgcaccacca ggaaggccga gccgtccggg
    18601 gtgagccggt ccagccactg ctccagcagc cgccgcagcg ccgccttgcc gatccggatc
    18661 ggcgggttgg agtagatcgc cgcgaaccgc agttcggccg ggacctcctc cggcagcgcg
    18721 gcgtgcacat tgcccaggcc cagcgactcc gcgttgtccc ggaccaggtc cagggcgcgg
    18781 ccgttgacgt ccaccgccca gaccgggagc cgcttgcggc ggctcgccca ggtcagcgcg
    18841 atcggtccgt agccgcagcc gatgtccagg atcgggccgc gcacccgggg cggcggcgcc
    18901 tgctccagca ggatccgggt gcccgggtcc aaccggctgc gggagaagac gcccgcgtcg
    18961 gtgctgagct ccagggtgag gtccggcagg gtgaccgtga tcggccggcg ctcgctggcg
    19021 acctcgggtg caccggagaa gtagtgcgag ccggacatgc gtttccccgt cgttcgtaag
    19081 ggcctcgggg ccaccgggag gtgtgggtaa gccctgctgg tacggctccg atcgtacccc
    19141 ggtgcccggc ggggcccgtg tcccgcgcgg cggggg
//
