BGC0002434 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002434 (Kitasatospora sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	19,176	clifednamide D/clifednamide E/clifednamide F/clifednamide G/clifednamide H/clifednamide I/clifednamide J	PKS+NRPS:Type I	100%

BGC0002434 - Region 1 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 19,176 nt. (total: 19,176 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,177
Label		BGC0002434

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002434	2.00	Polyketide, NRP	clifednamide D, clifednamide E, clifednamide F, clifednamide G, clifednamide H, clifednamide I, clifednamide J	Kitasatospora sp.
BGC0001275	0.66	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001244	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001553	0.64	NRP, Polyketide	clifednamide A	Streptomyces sp. JV178
BGC0001273	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001954	0.63	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001068	0.62	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002434	1.00	Polyketide, NRP	clifednamide D, clifednamide E, clifednamide F, clifednamide G, clifednamide H, clifednamide I, clifednamide J	Kitasatospora sp.
BGC0001275	0.66	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001553	0.65	NRP, Polyketide	clifednamide A	Streptomyces sp. JV178
BGC0001273	0.65	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001954	0.65	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001068	0.64	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19176:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal - Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cftB

Search NORINE for peptide: strict or relaxed

PKS_AT (603..904): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; CE-Malonyl-CoA: 54.2%; Acetyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 120.2
Methylmalonyl-CoA: 119.0
Methoxymalonyl-CoA: 113.4
Ethylmalonyl-CoA: 100.5
Isobutyryl-CoA: 89.7
Acetyl-CoA: 71.5
Propionyl-CoA: 70.7
2-Methylbutyryl-CoA: 57.9
Benzoyl-CoA: 57.7
trans-1,2-CPDA: 45.7
fatty_acid: 44.2
3-Methylbutyryl-CoA: 39.1
CHC-CoA: 37.3
inactive: 33.1

AMP-binding (2352..2768): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEVGSIDK
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (82% 8Å match)
Stachelhaus code match:: 100% (strong)