BGC0002435: coformycin biosynthetic gene cluster from Micromonospora haikouensis
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Location: 49,762 - 74,294 nt. (total: 24,533 nt).
This entry is originally from NCBI GenBank FMCW01000024.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002435
Short description coformycin biosynthetic gene cluster from Micromonospora haikouensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
FMCW01000024.1
49762 - 74294
via Heterologous expression, Knock-out studies, Enzymatic assays
Compounds
  • coformycin
  • aristeromycin
Species Micromonospora haikouensis [taxonomy]
References
Chemical products information
coformycin Evidence:
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Chemical database entries
NPAtlas
aristeromycin Evidence:
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Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • GA0070558_12444
  • SCF06432.1
 49762 - 50865 (-) Predicted arabinose efflux permease, MFS family
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    • GA0070558_12445
    • SCF06440.1
    		 51099 - 51917 (-) 5'-methylthioadenosine phosphorylase
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      • GA0070558_12446
      • SCF06447.1
      		 52009 - 52986 (-) GDP-L-fucose synthase
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        • GA0070558_12447
        • SCF06455.1
        		 53038 - 54504 (-) IMP dehydrogenase
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          • GA0070558_12448
          • SCF06463.1
          		 54514 - 55506 (-) adenosine deaminase
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            • GA0070558_12449
            • SCF06470.1
            		 55552 - 56298 (-) Phosphoglycolate phosphatase, HAD superfamily
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              • GA0070558_12450
              • SCF06476.1
              		 56300 - 57421 (-) Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily/HAD-superfamily hydrolase, subfamily IIB
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                • GA0070558_12451
                • SCF06487.1
                		 57642 - 58361 (-) Short-chain dehydrogenase
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                  • GA0070558_12452
                  • SCF06495.1
                  		 58345 - 59076 (-) phosphoribosylaminoimidazole-succinocarboxamide synthase
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                    • GA0070558_12453
                    • SCF06506.1
                    		 59099 - 59791 (-) probable phosphoglycerate mutase
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                      • GA0070558_12454
                      • SCF06515.1
                      		 59781 - 61004 (-) adenosylhomocysteinase
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                        • GA0070558_12455
                        • SCF06525.1
                        		 61001 - 62269 (-) adenosylhomocysteinase
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                          • GA0070558_12456
                          • SCF06535.1
                          		 62266 - 63084 (-) methylthioadenosine phosphorylase
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                            • GA0070558_12457
                            • SCF06541.1
                            		 63146 - 64570 (-) Phosphomannomutase
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                              • GA0070558_12458
                              • SCF06555.1
                              		 64588 - 65841 (-) adenosylhomocysteinase
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                                • GA0070558_12459
                                • SCF06559.1
                                		 65838 - 66872 (-) ribokinase
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                                  • GA0070558_12460
                                  • SCF06566.1
                                  		 66869 - 67288 (-) Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family
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                                    • GA0070558_12461
                                    • SCF06575.1
                                    		 67285 - 68034 (-) 3-oxoacyl-[acyl-carrier protein] reductase
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                                      • GA0070558_12462
                                      • SCF06581.1
                                      		 68027 - 68677 (-) DJ-1/PfpI family protein
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                                        • GA0070558_12463
                                        • SCF06587.1
                                        		 68674 - 69768 (-) myo-inositol-1-phosphate synthase
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                                          • GA0070558_12464
                                          • SCF06598.1
                                          		 69904 - 70908 (-) Predicted dehydrogenase
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                                            • GA0070558_12465
                                            • SCF06606.1
                                            		 71275 - 71937 (+) ATP phosphoribosyltransferase
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                                              • GA0070558_12466
                                              • SCF06618.1
                                              		 71958 - 73439 (-) adenosylhomocysteinase
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                                                • GA0070558_12467
                                                • SCF06629.1
                                                		 73641 - 74294 (-) Nucleoside-diphosphate-sugar epimerase
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                                                  Biosynthesis information
                                                  Annotation changelog

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Added chemical structures for compounds: coformycin.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-10-07
                                                  Added NPAtlas links to compounds: coformycin.
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Entry added
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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