LOCUS       BGC0002437             10596 bp    DNA     linear   BCT 04-APR-2016
DEFINITION  Thermoactinomyces sp. AS95 NODE_4, whole genome shotgun sequence.
ACCESSION   BGC0002437
VERSION     BGC0002437
KEYWORDS    .
SOURCE      Thermoactinomyces sp. AS95
  ORGANISM  Thermoactinomyces sp. AS95
            Bacteria; Firmicutes; Bacilli; Bacillales; Thermoactinomycetaceae;
            Thermoactinomyces; unclassified Thermoactinomyces.
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 09:31:29
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..10596
                     /locus_tag="AYX07_11040"
     protocluster    1..10596
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:10596]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..10596
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..10596
                     /SMILES="NC(C(C)CC)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10596
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002437"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10596
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             1..10596
                     /NRPS_PKS="Domain: Condensation_DCL (6-303). E-value:
                     3e-109. Score: 356.6. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (467-862). E-value:
                     8.9e-112. Score: 365.5. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (969-1038). E-value: 3.5e-25. Score:
                     79.9. Matches aSDomain: nrpspksdomains_AYX07_11040_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1053-1341). E-value:
                     1.7e-99. Score: 324.4. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1505-1886). E-value:
                     1.4e-114. Score: 374.7. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1992-2061). E-value: 8.3e-20.
                     Score: 62.6. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_PCP.2"
                     /NRPS_PKS="Domain: Condensation_LCL (2076-2365). E-value:
                     3.4e-102. Score: 333.3. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (2529-2910). E-value:
                     1.4e-114. Score: 374.7. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_AMP-binding.3"
                     /NRPS_PKS="Domain: PCP (3016-3080). E-value: 3e-25. Score:
                     80.1. Matches aSDomain: nrpspksdomains_AYX07_11040_PCP.3"
                     /NRPS_PKS="Domain: Epimerization (3093-3390). E-value:
                     2.1e-134. Score: 440.9. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (3398-3526). E-value: 1.4e-35.
                     Score: 114.2. Matches aSDomain:
                     nrpspksdomains_AYX07_11040_TIGR01720.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     350.9; E-value: 1.6e-106)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS+"
                     /locus_tag="AYX07_11040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS+."
                     /product="hypothetical protein"
                     /protein_id="KYQ85937.1"
                     /sec_met_domain="Condensation (E-value: 8.2e-90, bitscore:
                     286.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.2e-125, bitscore:
                     404.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6.4e-17, bitscore:
                     48.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKQVDIYSLSPMQEAMLFHSLYDQGNSYFKQLLIQVEGDFDPG
                     LFEKSLNVLIERYDIFRTVFIYKKLKKPRQVVLQEREAKIQYQDFSHLPEDERNQKVEA
                     WIRKDQTKPFDLSKDLLLRVSVLKTGSQQYQIVFSSHHILLDGWCMGIVFEDLFEIYGK
                     LKNHEPVPHKKVTQYRELIRWLEKQDPKETEQYWKQYLAGYEGHAKIPGAKTARGDDYK
                     LEEVRCSLDETLTRQFNQFAREHHLTLNNVFQTIWGLMLQRYNHTDDVVFGSVVSGRNK
                     DIPRIQEIVGLFINTIPVRVKASGDDRFTDLAKQVQQAALASEPYDYASLTDIQKAAQC
                     GDSLVDHIVVFENYVFDSNIFHKYRHQLGFVVTDAKSTFEKTNYDFNVIVVPCEKFTIL
                     FQYNGHVYQREDVESCFRHFERIVRQVIGNPDCRLKDIELVSPSEKQQWFAWNQTDADY
                     PRDKTVQEIFEEQAEKSPQQIALKFRGNTMTYKELNEQANQLARVLRKQGVRRGDIVGL
                     MTERSFEMMIGMLAAVKAGGAYMPIDPEYPAGRKEFMLEDAGAPVLMVQPGLKVPAGYK
                     GRVVELAPGEWAGEEKSNPENVNQPDDLLYVMYTSGSTGKPKGILTMHYNVMRTVINNG
                     YIQVHAGDRLLQLSNYCFDGSTFDIYNALLNGATLVLVPKEASKDFAELTKLIREEEIT
                     VTFMTTSLFNTVVDLDLDCLKSLRKIVFGGEKASVKHVQKAVQALGGNRLINGYGPTET
                     TVFAATYSIDPSVLATHRVPIGKPLNNTKLYVLDPWGNLQPPGIPGELCVSGDGVAKAY
                     LNRPELNETRFVPDPFHPGQRMYRTGDLVRLLPDGHLEYLERMDNQVKIRGHRIETGEV
                     EKRLFAHPDVLNAVVLADKDQNGHSYLCAYVVLKKDVSPSALREHMTKALPEYMIPDYF
                     VKLDQLPFTPNGKVDLRALPKPAEALENKRDYVAPTNPVEEKLVKVWQEVLDADQVGIH
                     DNFFDLGGHSLKAMMLSSRVSKELNADLPLREIFARPTVQQQAAFLQNKGKKEYTGIAP
                     APEMKDYPVTSAQKRLYMVSQLEGSGTSYNMPYVFRIHGDLSVPGLKSVLQSLVDRHES
                     LRTSFHMINGELRQKIHPDARLVVEQYQAGGKRQEKRVIQEFIRPFDLQKAPLMRAGVL
                     ERTDTREKYLLLDFHHIVADGVSIRQWFSDFSRRMQGEELPSLPLQYKDYAYWQQHEKQ
                     KDRWKKHEEYWLNELSGELPVLQLPTDFPRPKVQRFDGDQLPFEMDAGLSDQLRQLADE
                     QNATMYMVLFAAYHVLLSKYAGQEDLIVGSPIAGRPHADLETMVGMFANTLAVRTRPTP
                     DVSFARFLAQLKEQILEMAEHQDYPFEELVEKLGAERDLSRNPLFDTMFSLQKNELPAL
                     QFRDFSLELVEWDWKKSKFDMSWILIEDEKIKGIVEFATHLFKPETVKRMVRHYLHILK
                     QITENPDLRLSDIKLITPDEEHQVLNNFNAYRLEYPRGRTIPSWFEERVEKQPDRVAVV
                     CGEERWTYEELNRQANRLAHALRKKGIGREQLVGILMSPSKEMMAAVLGVLKAGAAYVP
                     IDPQYPADRIQYMLKDSGASLLLTDRPAVPGSSGVEVWDMKTKDFRGESDDNPAPVNKE
                     RDLAYVIYTSGSTGKPKGVMVEHASLINLCEWHIREFQVTPEDKSIKYAGVGFDASVWE
                     IFPTWMAGASLHIIEEAMRYDLEALNRYMEEQGITVAFLPTPVAEQFMQLENRSLRVLL
                     TGGDRLGRVLPQNYTVVNNYGPTENTVVTTSTPVRPDEPVTIGKPVANNQVYVLNEHQQ
                     LQPIGVPGELCVSGESLARGYLNRPELTAEKFVPNPYVPGQKMYRTGDLVRWLPDGRLE
                     FLGRMDEQVKIRGYRIEPGEIANRLLEHASVREAFVTVQLNPSQEPELCAYFAASSPCS
                     AEELREHLSLKLPDYMVPVHFIEMEKLPLTRNGKVDKKALPLPEADTTRSKDDAPATPA
                     EEQLIEILKEILHTEQIGVHDSFFEKGGNSLKGMMLSAQVHKRMHTELPLREIFARPVV
                     KEMAAYIENQKTAEHVTIAPAPKQAYYPVSSAQKRLYVVGQLEGMGTGYNMPHAFSIRG
                     NLPVSRLEEAFWALVERHESLRTSFHLIDGELMQKIHTDVEVRVECYQAQDRPDVKQKI
                     QQFIRPFDLEKAPLIRVGMIEHAKEEEQILVIDMHHIISDGVSMNILFQDLMKCLQGET
                     LPPVSLQYKDYAVWQQKEKQKDTWKKHEQYWMNELSGELPVLDLPTDYPRPSVQRFDGD
                     HMTFEIEHRLTRKLKRLVDEKKATPYMALLAAYNLLLAKYTGKNDIIVGSPIAGRSYAG
                     LESMVGMFANTLVVRNRIDLQLPFTVFLEQVKERVLQMYEHQDYPFEELVEKLDTQRDL
                     SRNPLFDTMFAMQNIDMPVFKLQGLKIRQGEIEWKKSKFDLSWMMAEDEETFKGVVEYS
                     TCLFKPGTIRRMIGHFVHILEQIVDDPGIRLCEIELPTLEEKWEILQTFNQTRLEYPRG
                     RTIPSWFEERVEKQPDRVAVVCGEERWTYEELNRQANRLAHALRKKGIGREQLVGILMS
                     PSKEMMAAVLGVLKAGAAYVPIDPQYPADRIQYMLKDSGASLLLTDRPAVPGSSGVEVW
                     DMKTKDFRGESDDNPAPVNKERDLAYVIYTSGSTGKPKGVMVEHASLINLCEWHIREFQ
                     VTPEDKSIKYAGVGFDASVWEIFPTWMAGASLHIIEEAMRYDLEALNRYMEEQGITVAF
                     LPTPVAEQFMQLENRSLRVLLTGGDRLGRVLPQNYTVVNNYGPTENTVVTTSTPVRPDE
                     PVTIGKPVANNQVYVLNEHQQLQPIGVPGELCVSGESLARGYLNRPELTAEKFVPNPYV
                     PGQKMYRTGDLVRWLPDGRLEFLGRMDEQVKIRGYRIEPGEVADKLLSYPTVKEAVVVA
                     QTDEQNQLHLCAYFTASESCSIPALRQYLGKELPDYMIPAYFMQMEQLPLNANGKVDKN
                     MLPKPKQMQTGVEYAAPRNEKERILAELWQEILHLDRVGIHDQFFELGGDSIKAMQIAS
                     RLKPYRLKMRLKDLFQHPTIEELAPHVFPIDEDREDEVVTGEVALTPIQRWMFEQTDYP
                     DQWNMAIVLYRKQGWDADVLKPVFHALVTHHDALRMSFKREDHQVKAWNRDVEGEFFSI
                     HEFDVNSEDLSEVMKREANRLHQSLRIHGGPLIRLGIFHTGEGDYLLIIIHHLVMDAVS
                     WRVLSEDLHTAYRQQLDGEPLALPQKTTSFQSWSHQLQEFANSPALLAEIPYWKATDRL
                     QVPKLPVDKKETSDYANQHIGIVWGRLPKEETGDLLSGAHRAYQTEMNDLLLSGLVMTL
                     NSWTHGKVAVQLEGHGREEVIDGVDLTRTVGWFTSMYPVVFEQDSKNPAEVIPYVKEVL
                     RRVPNKGIGYGILKYLTRPENKQDLSFRLKPEINFNYQGEFVRDVEKEDIQIVSLPVGE
                     GVHPLAQWPYKLDFSLFVENGELVTLIRYHQTLYHRETIEQLKNLYLHHLKRIVDFCRE
                     EVLVK"
     aSDomain        19..909
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_Condensation_DCL.1"
                     /domain_subtype="Condensation_DCL"
                     /evalue="3.00E-109"
                     /label="AYX07_11040_Condensation_DCL.1"
                     /locus_tag="AYX07_11040"
                     /protein_end="303"
                     /protein_start="6"
                     /score="356.6"
                     /tool="antismash"
                     /translation="DIYSLSPMQEAMLFHSLYDQGNSYFKQLLIQVEGDFDPGLFEKSL
                     NVLIERYDIFRTVFIYKKLKKPRQVVLQEREAKIQYQDFSHLPEDERNQKVEAWIRKDQ
                     TKPFDLSKDLLLRVSVLKTGSQQYQIVFSSHHILLDGWCMGIVFEDLFEIYGKLKNHEP
                     VPHKKVTQYRELIRWLEKQDPKETEQYWKQYLAGYEGHAKIPGAKTARGDDYKLEEVRC
                     SLDETLTRQFNQFAREHHLTLNNVFQTIWGLMLQRYNHTDDVVFGSVVSGRNKDIPRIQ
                     EIVGLFINTIPVRVKA"
     aSModule        19..3114
                     /complete
                     /domains="nrpspksdomains_AYX07_11040_Condensation_DCL.1"
                     /domains="nrpspksdomains_AYX07_11040_AMP-binding.1"
                     /domains="nrpspksdomains_AYX07_11040_PCP.1"
                     /locus_tags="AYX07_11040"
                     /monomer_pairings="ile -> ile"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       25..63
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0001"
                     /evalue="1.90E-03"
                     /label="C1_dual_004-017"
                     /locus_tag="AYX07_11040"
                     /protein_end="21"
                     /protein_start="8"
                     /score="11.3"
                     /tool="antismash"
                     /translation="YSLSPMQEAMLFH"
     CDS_motif       85..201
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0002"
                     /evalue="2.20E-13"
                     /label="C2_DCL_024-062"
                     /locus_tag="AYX07_11040"
                     /protein_end="67"
                     /protein_start="28"
                     /score="42.4"
                     /tool="antismash"
                     /translation="SYFKQLLIQVEGDFDPGLFEKSLNVLIERYDIFRTVFIY"
     CDS_motif       364..396
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0003"
                     /evalue="2.30E+01"
                     /label="Cy2"
                     /locus_tag="AYX07_11040"
                     /protein_end="132"
                     /protein_start="121"
                     /score="-1.8"
                     /tool="antismash"
                     /translation="LRVSVLKTGSQ"
     CDS_motif       421..483
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0004"
                     /evalue="3.80E-11"
                     /label="C3_DCL_135-156"
                     /locus_tag="AYX07_11040"
                     /protein_end="161"
                     /protein_start="140"
                     /score="35.4"
                     /tool="antismash"
                     /translation="HHILLDGWCMGIVFEDLFEIY"
     CDS_motif       805..900
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0005"
                     /evalue="4.50E-17"
                     /label="C5_DCL_263-294"
                     /locus_tag="AYX07_11040"
                     /protein_end="300"
                     /protein_start="268"
                     /score="54.4"
                     /tool="antismash"
                     /translation="DVVFGSVVSGRNKDIPRIQEIVGLFINTIPVR"
     CDS_motif       949..1062
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0006"
                     /evalue="4.10E-14"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="AYX07_11040"
                     /protein_end="354"
                     /protein_start="316"
                     /score="44.9"
                     /tool="antismash"
                     /translation="QQAALASEPYDYASLTDIQKAAQCGDSLVDHIVVFENY"
     aSDomain        1402..2586
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_AMP-binding.1"
                     /evalue="8.90E-112"
                     /label="AYX07_11040_AMP-binding.1"
                     /locus_tag="AYX07_11040"
                     /protein_end="862"
                     /protein_start="467"
                     /score="365.5"
                     /specificity="consensus: ile"
                     /tool="antismash"
                     /translation="FEEQAEKSPQQIALKFRGNTMTYKELNEQANQLARVLRKQGVRRG
                     DIVGLMTERSFEMMIGMLAAVKAGGAYMPIDPEYPAGRKEFMLEDAGAPVLMVQPGLKV
                     PAGYKGRVVELAPGEWAGEEKSNPENVNQPDDLLYVMYTSGSTGKPKGILTMHYNVMRT
                     VINNGYIQVHAGDRLLQLSNYCFDGSTFDIYNALLNGATLVLVPKEASKDFAELTKLIR
                     EEEITVTFMTTSLFNTVVDLDLDCLKSLRKIVFGGEKASVKHVQKAVQALGGNRLINGY
                     GPTETTVFAATYSIDPSVLATHRVPIGKPLNNTKLYVLDPWGNLQPPGIPGELCVSGDG
                     VAKAYLNRPELNETRFVPDPFHPGQRMYRTGDLVRLLPDGHLEYLERMDNQVKIR"
     CDS_motif       1588..1629
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0007"
                     /evalue="3.30E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="AYX07_11040"
                     /protein_end="543"
                     /protein_start="529"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LAAVKAGGAYMPID"
     CDS_motif       1816..1872
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0008"
                     /evalue="2.00E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="AYX07_11040"
                     /protein_end="624"
                     /protein_start="605"
                     /score="23.4"
                     /tool="antismash"
                     /translation="YVMYTSGSTGKPKGILTMH"
     CDS_motif       2242..2265
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0009"
                     /evalue="1.40E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="AYX07_11040"
                     /protein_end="755"
                     /protein_start="747"
                     /score="5.5"
                     /tool="antismash"
                     /translation="YGPTETTV"
     CDS_motif       2380..2469
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0010"
                     /evalue="1.80E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="AYX07_11040"
                     /protein_end="823"
                     /protein_start="793"
                     /score="42.6"
                     /tool="antismash"
                     /translation="PPGIPGELCVSGDGVAKAYLNRPELNETRF"
     CDS_motif       2551..2616
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0011"
                     /evalue="8.10E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="AYX07_11040"
                     /protein_end="872"
                     /protein_start="850"
                     /score="30.8"
                     /tool="antismash"
                     /translation="YLERMDNQVKIRGHRIETGEVE"
     aSDomain        2908..3114
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_PCP.1"
                     /evalue="3.50E-25"
                     /label="AYX07_11040_PCP.1"
                     /locus_tag="AYX07_11040"
                     /protein_end="1038"
                     /protein_start="969"
                     /score="79.9"
                     /tool="antismash"
                     /translation="EEKLVKVWQEVLDADQVGIHDNFFDLGGHSLKAMMLSSRVSKELN
                     ADLPLREIFARPTVQQQAAFLQNK"
     aSDomain        3160..4023
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.70E-99"
                     /label="AYX07_11040_Condensation_LCL.1"
                     /locus_tag="AYX07_11040"
                     /protein_end="1341"
                     /protein_start="1053"
                     /score="324.4"
                     /tool="antismash"
                     /translation="DYPVTSAQKRLYMVSQLEGSGTSYNMPYVFRIHGDLSVPGLKSVL
                     QSLVDRHESLRTSFHMINGELRQKIHPDARLVVEQYQAGGKRQEKRVIQEFIRPFDLQK
                     APLMRAGVLERTDTREKYLLLDFHHIVADGVSIRQWFSDFSRRMQGEELPSLPLQYKDY
                     AYWQQHEKQKDRWKKHEEYWLNELSGELPVLQLPTDFPRPKVQRFDGDQLPFEMDAGLS
                     DQLRQLADEQNATMYMVLFAAYHVLLSKYAGQEDLIVGSPIAGRPHADLETMVGMFANT
                     LAVRTRP"
     aSModule        3160..6183
                     /complete
                     /domains="nrpspksdomains_AYX07_11040_Condensation_LCL.1"
                     /domains="nrpspksdomains_AYX07_11040_AMP-binding.2"
                     /domains="nrpspksdomains_AYX07_11040_PCP.2"
                     /locus_tags="AYX07_11040"
                     /monomer_pairings="leu -> leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       3223..3339
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0012"
                     /evalue="4.50E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="AYX07_11040"
                     /protein_end="1113"
                     /protein_start="1074"
                     /score="48.0"
                     /tool="antismash"
                     /translation="TSYNMPYVFRIHGDLSVPGLKSVLQSLVDRHESLRTSFH"
     CDS_motif       3538..3594
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0013"
                     /evalue="8.10E-05"
                     /label="C3_LCL_132-143"
                     /locus_tag="AYX07_11040"
                     /protein_end="1198"
                     /protein_start="1179"
                     /score="15.3"
                     /tool="antismash"
                     /translation="FHHIVADGVSIRQWFSDFS"
     CDS_motif       3634..3666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0014"
                     /evalue="7.60E-03"
                     /label="C4_LCL_164-176"
                     /locus_tag="AYX07_11040"
                     /protein_end="1222"
                     /protein_start="1211"
                     /score="9.2"
                     /tool="antismash"
                     /translation="QYKDYAYWQQH"
     CDS_motif       3925..4014
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0015"
                     /evalue="4.30E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="AYX07_11040"
                     /protein_end="1338"
                     /protein_start="1308"
                     /score="48.0"
                     /tool="antismash"
                     /translation="DLIVGSPIAGRPHADLETMVGMFANTLAVR"
     CDS_motif       4072..4182
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0016"
                     /evalue="3.30E-19"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="AYX07_11040"
                     /protein_end="1394"
                     /protein_start="1357"
                     /score="61.3"
                     /tool="antismash"
                     /translation="ILEMAEHQDYPFEELVEKLGAERDLSRNPLFDTMFSL"
     aSDomain        4516..5658
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_AMP-binding.2"
                     /evalue="1.40E-114"
                     /label="AYX07_11040_AMP-binding.2"
                     /locus_tag="AYX07_11040"
                     /protein_end="1886"
                     /protein_start="1505"
                     /score="374.7"
                     /specificity="consensus: leu"
                     /tool="antismash"
                     /translation="FEERVEKQPDRVAVVCGEERWTYEELNRQANRLAHALRKKGIGRE
                     QLVGILMSPSKEMMAAVLGVLKAGAAYVPIDPQYPADRIQYMLKDSGASLLLTDRPAVP
                     GSSGVEVWDMKTKDFRGESDDNPAPVNKERDLAYVIYTSGSTGKPKGVMVEHASLINLC
                     EWHIREFQVTPEDKSIKYAGVGFDASVWEIFPTWMAGASLHIIEEAMRYDLEALNRYME
                     EQGITVAFLPTPVAEQFMQLENRSLRVLLTGGDRLGRVLPQNYTVVNNYGPTENTVVTT
                     STPVRPDEPVTIGKPVANNQVYVLNEHQQLQPIGVPGELCVSGESLARGYLNRPELTAE
                     KFVPNPYVPGQKMYRTGDLVRWLPDGRLEFLGRMDEQVKIR"
     CDS_motif       4702..4743
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0017"
                     /evalue="1.20E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="AYX07_11040"
                     /protein_end="1581"
                     /protein_start="1567"
                     /score="18.3"
                     /tool="antismash"
                     /translation="LGVLKAGAAYVPID"
     CDS_motif       4924..4983
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0018"
                     /evalue="2.40E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="AYX07_11040"
                     /protein_end="1661"
                     /protein_start="1641"
                     /score="35.2"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVMVEH"
     CDS_motif       5323..5355
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0019"
                     /evalue="1.30E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="AYX07_11040"
                     /protein_end="1785"
                     /protein_start="1774"
                     /score="8.4"
                     /tool="antismash"
                     /translation="NYGPTENTVVT"
     CDS_motif       5452..5541
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0020"
                     /evalue="9.40E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="AYX07_11040"
                     /protein_end="1847"
                     /protein_start="1817"
                     /score="56.3"
                     /tool="antismash"
                     /translation="PIGVPGELCVSGESLARGYLNRPELTAEKF"
     CDS_motif       5623..5685
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0021"
                     /evalue="2.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="AYX07_11040"
                     /protein_end="1895"
                     /protein_start="1874"
                     /score="35.5"
                     /tool="antismash"
                     /translation="FLGRMDEQVKIRGYRIEPGEI"
     aSDomain        5977..6183
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_PCP.2"
                     /evalue="8.30E-20"
                     /label="AYX07_11040_PCP.2"
                     /locus_tag="AYX07_11040"
                     /protein_end="2061"
                     /protein_start="1992"
                     /score="62.6"
                     /tool="antismash"
                     /translation="EEQLIEILKEILHTEQIGVHDSFFEKGGNSLKGMMLSAQVHKRMH
                     TELPLREIFARPVVKEMAAYIENQ"
     aSDomain        6229..7095
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_Condensation_LCL.2"
                     /domain_subtype="Condensation_LCL"
                     /evalue="3.40E-102"
                     /label="AYX07_11040_Condensation_LCL.2"
                     /locus_tag="AYX07_11040"
                     /protein_end="2365"
                     /protein_start="2076"
                     /score="333.3"
                     /tool="antismash"
                     /translation="YYPVSSAQKRLYVVGQLEGMGTGYNMPHAFSIRGNLPVSRLEEAF
                     WALVERHESLRTSFHLIDGELMQKIHTDVEVRVECYQAQDRPDVKQKIQQFIRPFDLEK
                     APLIRVGMIEHAKEEEQILVIDMHHIISDGVSMNILFQDLMKCLQGETLPPVSLQYKDY
                     AVWQQKEKQKDTWKKHEQYWMNELSGELPVLDLPTDYPRPSVQRFDGDHMTFEIEHRLT
                     RKLKRLVDEKKATPYMALLAAYNLLLAKYTGKNDIIVGSPIAGRSYAGLESMVGMFANT
                     LVVRNRID"
     aSModule        6229..10578
                     /complete
                     /domains="nrpspksdomains_AYX07_11040_Condensation_LCL.2"
                     /domains="nrpspksdomains_AYX07_11040_AMP-binding.3"
                     /domains="nrpspksdomains_AYX07_11040_PCP.3"
                     /domains="nrpspksdomains_AYX07_11040_Epimerization.1"
                     /domains="nrpspksdomains_AYX07_11040_TIGR01720.1"
                     /locus_tags="AYX07_11040"
                     /monomer_pairings="leu -> D-leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6298..6408
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0022"
                     /evalue="2.50E-14"
                     /label="C2_LCL_024-062"
                     /locus_tag="AYX07_11040"
                     /protein_end="2136"
                     /protein_start="2099"
                     /score="45.6"
                     /tool="antismash"
                     /translation="YNMPHAFSIRGNLPVSRLEEAFWALVERHESLRTSFH"
     CDS_motif       6607..6666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0023"
                     /evalue="9.60E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="AYX07_11040"
                     /protein_end="2222"
                     /protein_start="2202"
                     /score="27.8"
                     /tool="antismash"
                     /translation="MHHIISDGVSMNILFQDLMK"
     CDS_motif       6703..6735
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0024"
                     /evalue="3.30E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="AYX07_11040"
                     /protein_end="2245"
                     /protein_start="2234"
                     /score="13.3"
                     /tool="antismash"
                     /translation="QYKDYAVWQQK"
     CDS_motif       6994..7083
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0025"
                     /evalue="1.70E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="AYX07_11040"
                     /protein_end="2361"
                     /protein_start="2331"
                     /score="46.1"
                     /tool="antismash"
                     /translation="DIIVGSPIAGRSYAGLESMVGMFANTLVVR"
     CDS_motif       7132..7251
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0026"
                     /evalue="5.50E-20"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="AYX07_11040"
                     /protein_end="2417"
                     /protein_start="2377"
                     /score="63.8"
                     /tool="antismash"
                     /translation="KERVLQMYEHQDYPFEELVEKLDTQRDLSRNPLFDTMFAM"
     aSDomain        7588..8730
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_AMP-binding.3"
                     /evalue="1.40E-114"
                     /label="AYX07_11040_AMP-binding.3"
                     /locus_tag="AYX07_11040"
                     /protein_end="2910"
                     /protein_start="2529"
                     /score="374.7"
                     /specificity="consensus: leu"
                     /tool="antismash"
                     /translation="FEERVEKQPDRVAVVCGEERWTYEELNRQANRLAHALRKKGIGRE
                     QLVGILMSPSKEMMAAVLGVLKAGAAYVPIDPQYPADRIQYMLKDSGASLLLTDRPAVP
                     GSSGVEVWDMKTKDFRGESDDNPAPVNKERDLAYVIYTSGSTGKPKGVMVEHASLINLC
                     EWHIREFQVTPEDKSIKYAGVGFDASVWEIFPTWMAGASLHIIEEAMRYDLEALNRYME
                     EQGITVAFLPTPVAEQFMQLENRSLRVLLTGGDRLGRVLPQNYTVVNNYGPTENTVVTT
                     STPVRPDEPVTIGKPVANNQVYVLNEHQQLQPIGVPGELCVSGESLARGYLNRPELTAE
                     KFVPNPYVPGQKMYRTGDLVRWLPDGRLEFLGRMDEQVKIR"
     CDS_motif       7774..7815
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0027"
                     /evalue="1.20E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="AYX07_11040"
                     /protein_end="2605"
                     /protein_start="2591"
                     /score="18.3"
                     /tool="antismash"
                     /translation="LGVLKAGAAYVPID"
     CDS_motif       7996..8055
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0028"
                     /evalue="2.40E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="AYX07_11040"
                     /protein_end="2685"
                     /protein_start="2665"
                     /score="35.2"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVMVEH"
     CDS_motif       8395..8427
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0029"
                     /evalue="1.30E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="AYX07_11040"
                     /protein_end="2809"
                     /protein_start="2798"
                     /score="8.4"
                     /tool="antismash"
                     /translation="NYGPTENTVVT"
     CDS_motif       8524..8613
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0030"
                     /evalue="9.40E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="AYX07_11040"
                     /protein_end="2871"
                     /protein_start="2841"
                     /score="56.3"
                     /tool="antismash"
                     /translation="PIGVPGELCVSGESLARGYLNRPELTAEKF"
     CDS_motif       8695..8757
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0031"
                     /evalue="5.40E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="AYX07_11040"
                     /protein_end="2919"
                     /protein_start="2898"
                     /score="34.5"
                     /tool="antismash"
                     /translation="FLGRMDEQVKIRGYRIEPGEV"
     aSDomain        9049..9240
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_PCP.3"
                     /evalue="3.00E-25"
                     /label="AYX07_11040_PCP.3"
                     /locus_tag="AYX07_11040"
                     /protein_end="3080"
                     /protein_start="3016"
                     /score="80.1"
                     /tool="antismash"
                     /translation="ERILAELWQEILHLDRVGIHDQFFELGGDSIKAMQIASRLKPYRL
                     KMRLKDLFQHPTIEELAPH"
     aSDomain        9280..10170
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_Epimerization.1"
                     /evalue="2.10E-134"
                     /label="AYX07_11040_Epimerization.1"
                     /locus_tag="AYX07_11040"
                     /protein_end="3390"
                     /protein_start="3093"
                     /score="440.9"
                     /tool="antismash"
                     /translation="TGEVALTPIQRWMFEQTDYPDQWNMAIVLYRKQGWDADVLKPVFH
                     ALVTHHDALRMSFKREDHQVKAWNRDVEGEFFSIHEFDVNSEDLSEVMKREANRLHQSL
                     RIHGGPLIRLGIFHTGEGDYLLIIIHHLVMDAVSWRVLSEDLHTAYRQQLDGEPLALPQ
                     KTTSFQSWSHQLQEFANSPALLAEIPYWKATDRLQVPKLPVDKKETSDYANQHIGIVWG
                     RLPKEETGDLLSGAHRAYQTEMNDLLLSGLVMTLNSWTHGKVAVQLEGHGREEVIDGVD
                     LTRTVGWFTSMYPVVF"
     CDS_motif       9295..9324
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0032"
                     /evalue="9.50E-04"
                     /label="NRPS-E1"
                     /locus_tag="AYX07_11040"
                     /protein_end="3108"
                     /protein_start="3098"
                     /score="12.2"
                     /tool="antismash"
                     /translation="LTPIQRWMFE"
     CDS_motif       9418..9462
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0033"
                     /evalue="2.20E-02"
                     /label="Cy2"
                     /locus_tag="AYX07_11040"
                     /protein_end="3154"
                     /protein_start="3139"
                     /score="7.6"
                     /tool="antismash"
                     /translation="LVTHHDALRMSFKRE"
     CDS_motif       9652..9717
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0034"
                     /evalue="7.30E-09"
                     /label="NRPS-E2"
                     /locus_tag="AYX07_11040"
                     /protein_end="3239"
                     /protein_start="3217"
                     /score="28.0"
                     /tool="antismash"
                     /translation="LLIIIHHLVMDAVSWRVLSEDL"
     CDS_motif       10120..10167
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0035"
                     /evalue="1.30E-08"
                     /label="NRPS-E5"
                     /locus_tag="AYX07_11040"
                     /protein_end="3389"
                     /protein_start="3373"
                     /score="26.8"
                     /tool="antismash"
                     /translation="DLTRTVGWFTSMYPVV"
     aSDomain        10195..10578
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AYX07_11040_TIGR01720.1"
                     /evalue="1.40E-35"
                     /label="AYX07_11040_TIGR01720.1"
                     /locus_tag="AYX07_11040"
                     /protein_end="3526"
                     /protein_start="3398"
                     /score="114.2"
                     /tool="antismash"
                     /translation="EVIPYVKEVLRRVPNKGIGYGILKYLTRPENKQDLSFRLKPEINF
                     NYQGEFVRDVEKEDIQIVSLPVGEGVHPLAQWPYKLDFSLFVENGELVTLIRYHQTLYH
                     RETIEQLKNLYLHHLKRIVDFCRE"
     CDS_motif       10210..10272
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AYX07_11040_0036"
                     /evalue="8.10E-11"
                     /label="NRPS-E6"
                     /locus_tag="AYX07_11040"
                     /protein_end="3424"
                     /protein_start="3403"
                     /score="34.0"
                     /tool="antismash"
                     /translation="VKEVLRRVPNKGIGYGILKYL"
ORIGIN
        1 atggataaaa aacaggtgga catctattct ttgtctccca tgcaagaggc catgctgttt
       61 cactcgttat atgaccaggg gaattcttat ttcaaacaat tgttgatcca ggtggagggg
      121 gattttgatc ccggactgtt tgaaaagagt ttaaatgttt tgattgaacg atatgacatt
      181 ttccggactg tgtttattta taaaaagctg aaaaaaccac gtcaggtggt tttgcaagag
      241 cgcgaagcaa agattcagta tcaggatttt tcccatcttc cggaagatga gcggaatcaa
      301 aaggttgaag catggatccg aaaagatcaa accaaaccgt ttgatttgtc caaagatttg
      361 ttattgcgtg tttccgtgtt gaaaacaggg tcccaacagt atcaaatcgt gttcagcagc
      421 caccacatcc ttttggacgg atggtgcatg gggatcgtgt ttgaagattt gttcgaaatt
      481 tatgggaagc tgaaaaatca cgagcccgtt ccccacaaaa aagtgacgca atatcgtgaa
      541 ttgatccgtt ggctggaaaa gcaggatccc aaagaaacag aacaatattg gaaacagtat
      601 ttggccgggt atgaaggaca tgccaaaatt ccgggagcga agaccgcccg cggcgatgat
      661 tacaagttgg aggaagtccg ttgttcactg gatgaaacgt tgaccaggca attcaatcaa
      721 tttgcccgtg aacatcatct caccctgaac aatgtattcc aaacaatctg gggattgatg
      781 ttgcaacggt acaatcacac ggacgatgtg gtgttcggtt ccgtggtctc cggaaggaac
      841 aaagacattc cccggatcca ggagatcgtc ggtttgttca tcaacaccat tcccgtgcgg
      901 gtcaaagcaa gtggcgatga ccgttttaca gacctggcca aacaagttca acaagcggcg
      961 ctggcctcgg agccgtatga ttatgcttcg ttgaccgata ttcagaaagc ggcgcaatgc
     1021 ggcgattcat tggttgacca tattgttgtg tttgaaaatt atgtgtttga ttcgaatatt
     1081 ttccataaat accggcatca attggggttt gtcgtgacgg atgccaagag cacgtttgaa
     1141 aaaaccaact atgactttaa tgtgattgtg gtgccctgtg agaaattcac cattttgttt
     1201 caatacaacg gacatgttta ccaaagagaa gacgtggaat cctgtttccg ccactttgaa
     1261 cggattgtcc gccaagtcat tggaaatccg gattgccgct tgaaagacat tgaactggtt
     1321 tccccttcgg aaaagcagca gtggtttgca tggaatcaaa cggatgcgga ttatccgcgc
     1381 gataaaaccg ttcaggagat ttttgaagaa caggcggaaa aatccccgca gcaaatcgcc
     1441 ttgaaattcc ggggaaatac gatgacttac aaagagttga atgaacaagc caatcagctg
     1501 gcgagagtgt tgaggaaaca aggcgtccgg cgcggggaca ttgtcggatt gatgacggaa
     1561 cgctcctttg aaatgatgat cggcatgctg gcggccgtca aagccggtgg ggcttatatg
     1621 ccgattgatc cggaatatcc cgctggacgg aaggaattta tgctggaaga tgccggtgct
     1681 ccggttctca tggtgcagcc gggactgaaa gtgcctgccg gttataaagg gcgagtggtt
     1741 gaactggctc ccggcgaatg ggcgggggag gaaaaaagca acccggagaa tgtcaatcag
     1801 ccggatgatc ttctttacgt catgtatact tccggatcga ccggcaagcc caaaggcatt
     1861 ttgaccatgc attacaatgt gatgcggacg gtcatcaaca acgggtacat acaggtgcat
     1921 gccggggacc ggctgttgca gttgtcaaac tattgttttg acggatccac gtttgatatc
     1981 tacaatgcct tgttgaacgg agcgacgctg gttttggtgc ccaaagaggc ttccaaagac
     2041 tttgcggagc tgaccaaatt gatccgagag gaagagatta ccgtcacctt tatgaccact
     2101 tccctgttta acacggttgt ggatttggat cttgattgtt taaagagctt gcgcaaaatt
     2161 gtctttggcg gggaaaaggc ttcggtcaaa catgttcaaa aggcagtgca agcactgggc
     2221 ggaaaccgac tgatcaacgg gtacggaccg acggaaacca cggtttttgc cgcgacttat
     2281 tccattgatc cgtcagtgtt ggccacccat cgtgtaccga ttggaaagcc gctgaacaac
     2341 accaagctgt atgtgttgga cccatgggga aatcttcaac cgcccggcat tcccggtgaa
     2401 ctttgcgtca gtggcgacgg agtggccaaa gcgtatttaa accgtcccga attaaatgaa
     2461 acccgctttg ttccggatcc gttccatccc ggtcaacgca tgtaccgcac cggggatttg
     2521 gttcgcctgt tgccggatgg ccatttggaa tatttggagc ggatggataa tcaggtgaaa
     2581 atccggggac accgcattga gaccggtgaa gtggaaaaga ggttgtttgc ccatcccgat
     2641 gtgctgaatg cggtggtttt ggccgataaa gatcagaacg ggcattccta tttgtgtgct
     2701 tatgttgtgt tgaaaaagga tgtttcacct tctgcattgc gtgagcacat gaccaaagcg
     2761 ttgccggaat acatgatccc cgattacttt gtaaaattgg atcaacttcc gtttacgccc
     2821 aatggaaaag tggacttgcg ggcgcttccc aaaccggccg aagcgttgga gaacaaaagg
     2881 gattatgttg cccccacgaa ccccgtggaa gaaaagctgg taaaagtctg gcaggaagtt
     2941 ttggatgcgg accaagtcgg gattcatgac aacttctttg acctgggggg acactccctg
     3001 aaagcgatga tgctttcttc gcgggtgagc aaggaattga atgcagactt gccgctaaga
     3061 gagatttttg cccggccgac ggtgcagcaa caagcggcct ttttgcagaa taagggcaaa
     3121 aaagaataca ccgggattgc cccggcaccg gagatgaagg attatccggt gacttccgcg
     3181 cagaagcgct tatatatggt cagccaactg gaaggaagcg gcaccagtta caatatgcct
     3241 tatgtattcc ggattcacgg cgatttgtcc gttcccggtt taaagagcgt cttgcaatct
     3301 ttggtggacc ggcatgaatc gttgagaacg tctttccaca tgattaacgg ggaattaagg
     3361 cagaaaattc atcccgatgc ccgattggtc gtcgagcagt accaagccgg cgggaaacgg
     3421 caagaaaaac gtgtcattca agaatttatc cgcccgtttg atttgcaaaa ggcgccgttg
     3481 atgcgtgccg gggtgttgga acgtacggac acccgcgaga agtatctgtt attggatttt
     3541 catcatatcg tggctgatgg tgtttcgatc cggcaatggt tttccgattt ttcgcggcgg
     3601 atgcaaggtg aagagttgcc ttcgcttcca ttgcaataca aggattatgc ttattggcaa
     3661 caacatgaga aacaaaaaga ccgttggaaa aaacatgagg agtactggtt gaatgaactt
     3721 tccggcgagt tgcccgtttt gcaattgccg accgactttc cgcgcccgaa agttcagcgt
     3781 tttgacgggg atcagcttcc ttttgaaatg gatgcgggat tgtcggatca attaaggcag
     3841 ctggccgatg agcagaatgc aacgatgtat atggtgttgt ttgccgctta tcatgtcctg
     3901 ctctccaagt acgcggggca agaggatttg attgtcgggt cccccatcgc cggaaggccg
     3961 catgcggacc tggagaccat ggtgggcatg tttgccaaca cgctggcggt ccgaacccgg
     4021 ccgacaccgg atgtatcgtt tgcccggttt ctcgcgcaat tgaaagaaca aatcctggag
     4081 atggcagagc atcaggatta tccctttgaa gaactggtgg aaaaattggg ggcagaacgg
     4141 gatttaagcc ggaatcctct ttttgacacc atgttttctt tgcaaaagaa tgaattgccg
     4201 gcccttcagt tccgggattt ttcgctggaa ctggttgaat gggattggaa aaaatccaag
     4261 tttgatatga gctggatcct gattgaagat gagaaaatca aagggatcgt ggaatttgcc
     4321 acgcatctgt tcaagccgga aacggtaaaa agaatggttc gccattatct tcatattttg
     4381 aagcaaatca cggagaatcc ggaccttcgc ctgtctgaca tcaaattgat cacgccggat
     4441 gaagagcatc aggtgttaaa caatttcaat gcgtatcgtc tggagtatcc gcggggaaga
     4501 acgattccgt cctggtttga agaacgggtg gaaaagcaac cggaccgggt ggcggtggtt
     4561 tgcggcgaag aacggtggac ttatgaagag ttaaaccggc aggccaaccg cctggcccat
     4621 gcattgagga agaaagggat cggccgcgag caactggtcg gcatcctgat gtccccgtcc
     4681 aaagagatga tggcggcggt tctcggtgtc ttgaaagcag gggcggcgta cgttccgatc
     4741 gacccgcaat atccggcgga ccggatccaa tatatgttga aagacagcgg ggcttccctg
     4801 cttcttacgg atcgtccggc cgttcccggc agttccggcg tggaagtttg ggatatgaaa
     4861 accaaagatt tccggggcga atccgatgac aaccccgcac cggtgaacaa agaacgggat
     4921 ttggcctacg tgatctatac gtccggttcc accggaaaac ccaaaggcgt gatggtggaa
     4981 cacgcctccc tgatcaattt gtgcgagtgg catatccgtg aatttcaggt gacaccggaa
     5041 gataagagca tcaaatacgc aggggtcgga tttgatgcct cggtatggga gattttcccg
     5101 acttggatgg cgggagcgtc gcttcacatc attgaagagg ccatgcgtta tgatctggag
     5161 gcactgaacc ggtacatgga ggaacaaggg atcacggttg cttttctgcc gacgccggtg
     5221 gcggagcaat ttatgcagct ggaaaaccgc agcctgagag tgttgctgac cggaggggac
     5281 cggttgggcc gggtgttgcc gcagaactac acggtggtca acaattacgg tccgacggag
     5341 aacacggtgg tgacgacgag caccccggtg cgtccggatg aacccgtcac gattggaaaa
     5401 ccggtggcca ataaccaagt gtatgtgttg aatgaacatc agcaattgca gccaatcggc
     5461 gtgccgggcg agctgtgcgt cagcggggaa agtctggccc ggggatattt gaaccggccg
     5521 gagctgacgg cggagaagtt tgtgcccaac ccttatgtgc cggggcaaaa gatgtaccgg
     5581 accggagacc tggtgcggtg gctgccggac gggcgcttgg agtttctggg gcggatggat
     5641 gaacaggtga aaatccgcgg ttaccgcatt gagcccgggg aaatcgccaa ccgtttgttg
     5701 gagcatgctt ccgtccggga ggcctttgtc accgtgcagc tgaatccttc tcaagaaccg
     5761 gagttatgcg catatttcgc agcgtcgtct ccttgttccg cggaagaatt acgggagcat
     5821 ttaagtttga aattgcctga ctatatggtt ccggttcact ttatcgaaat ggagaaactc
     5881 cccttgaccc gaaacggcaa agtggacaaa aaagcattgc cgttgccgga agccgacaca
     5941 acccgaagca aggatgacgc accggccact cccgccgagg agcagttgat cgaaatcttg
     6001 aaggagattc tccataccga acaaatcgga gtccatgaca gcttctttga aaaaggcggc
     6061 aactccctca aagggatgat gttgtcggcg caagtccaca agaggatgca tacggaactg
     6121 cctttgcggg agatttttgc ccgtcccgtg gtcaaggaga tggccgcata catcgaaaat
     6181 caaaaaacgg ctgaacatgt caccatcgct ccggcaccca aacaagctta ttatccggtt
     6241 tcatccgcac agaaacggtt gtatgtggtc gggcaactgg aaggaatggg caccggttac
     6301 aacatgcccc atgccttttc catccgagga aatttgccgg tttcccgtct cgaagaagca
     6361 ttctgggcac tggtggaacg gcacgaatcc ttgcgtactt cgtttcatct cattgatggc
     6421 gaattgatgc aaaaaattca caccgatgtg gaggtccggg tggagtgtta tcaagcccaa
     6481 gaccgtccgg atgtgaaaca aaaaattcaa cagttcatcc gtccgtttga tttggagaaa
     6541 gctccgttga tccgggtcgg aatgatcgaa catgccaagg aagaagaaca gatcttggtc
     6601 atcgacatgc atcacatcat ttccgacggt gtctcgatga acatcctgtt tcaggatttg
     6661 atgaaatgcc tgcagggaga aacgttgccg ccggtgtccc tgcaatacaa ggattatgcc
     6721 gtctggcaac aaaaggaaaa acaaaaggat acatggaaaa aacacgagca gtattggatg
     6781 aatgaacttt ccggcgaact tccggttctg gatttgccca cggattaccc gcgaccttcc
     6841 gtacaacggt ttgacgggga ccatatgact ttcgaaatcg agcaccgatt aacccggaaa
     6901 ttgaaacggc ttgtggatga gaaaaaagcg actccgtata tggcactctt ggccgcgtac
     6961 aatttgctgt tggcgaaata caccggcaaa aacgacatca ttgtcggctc gccgattgcc
     7021 ggaagatcgt atgccggttt ggagtccatg gtggggatgt ttgccaatac gcttgtggtt
     7081 cgcaaccgga ttgatttgca acttccgttc acagtctttt tggaacaggt gaaggaacgc
     7141 gtcctgcaaa tgtatgagca tcaggattat ccgtttgagg aattggtgga aaagttggat
     7201 acccagcgcg atttgagccg caatcccctt tttgacacca tgtttgccat gcagaatatc
     7261 gacatgccgg tttttaaact gcaaggattg aaaattcgcc aaggggagat tgaatggaaa
     7321 aaatcgaaat ttgatttgag ctggatgatg gcggaagatg aggaaacatt caaaggggtt
     7381 gtcgaataca gcacttgcct gttcaagccc gggaccatcc ggcgtatgat tggccacttt
     7441 gttcatattc tcgaacagat tgtggatgat cccggaattc ggctgtgcga gattgagctt
     7501 cccacgttgg aagagaaatg ggagatattg caaaccttta accaaacccg tctggagtat
     7561 cctcggggaa gaacgattcc gtcctggttt gaagaacggg tggaaaagca accggaccgg
     7621 gtggcggtgg tttgtggcga agaacggtgg acttatgaag agttgaaccg gcaggccaac
     7681 cgcctggccc atgcgctgag gaagaaaggg atcggccgcg agcaactggt cggcatcctg
     7741 atgtccccgt ccaaagagat gatggcggcg gttctcggtg tcttgaaagc aggggcggcg
     7801 tacgttccga tcgacccgca atatccggcg gaccggatcc aatatatgtt gaaagacagc
     7861 ggggcttccc tgcttcttac ggatcgtccg gccgttcccg gcagttccgg cgtggaagtt
     7921 tgggatatga aaaccaaaga tttccggggc gaatccgatg acaaccccgc accggtgaac
     7981 aaagaacggg atttggccta cgtgatctat acgtccggtt ccaccggaaa acccaaaggc
     8041 gtgatggtgg aacacgcctc cctgatcaat ttgtgcgagt ggcatatccg tgaatttcag
     8101 gtgacaccgg aagataagag catcaaatac gcaggggtcg gatttgatgc ctcggtatgg
     8161 gagattttcc cgacttggat ggcgggagcg tcgcttcaca tcattgaaga ggccatgcgt
     8221 tatgatctgg aggcactgaa ccggtacatg gaggaacaag ggatcacggt tgcttttctg
     8281 ccgacgccgg tggcggagca atttatgcag ctggaaaacc gcagcctgag agtgttgctg
     8341 accggagggg accggttggg ccgggtgttg ccgcagaact acacggtggt caacaattac
     8401 ggtccgacgg agaacacggt ggtgacgacg agcaccccgg tgcgtccgga tgaacccgtc
     8461 acgattggaa aaccggtggc caataaccaa gtgtatgtgt tgaatgaaca tcagcaattg
     8521 cagccaatcg gcgtgccggg cgagctgtgc gtcagcgggg aaagtctggc ccggggatat
     8581 ttgaaccggc cggagctgac ggcggagaag tttgtgccca acccttatgt gccggggcaa
     8641 aagatgtacc ggaccggaga cctggtgcgg tggctgccgg acgggcgctt ggagtttctg
     8701 gggcggatgg atgaacaggt gaaaatccgc ggttaccgca ttgagcccgg ggaagtggcc
     8761 gacaagttgt taagttaccc gaccgtgaaa gaagccgtgg tggtggcgca aaccgacgaa
     8821 caaaatcagt tgcatttgtg tgcatatttc acggcatcgg agtcctgttc cattcctgca
     8881 ttgcggcagt acctggggaa agaattgcct gattacatga ttccggctta cttcatgcag
     8941 atggagcaac tgccgttgaa tgccaacggt aaagtggaca aaaacatgct tcccaaaccc
     9001 aaacagatgc aaaccggcgt ggaatatgcg gcgccccgca atgaaaagga acgcatcctg
     9061 gcggagctgt ggcaggaaat tttgcatctg gaccgggtgg ggatccatga tcagtttttt
     9121 gagcttggtg gcgattccat caaagcgatg caaattgctt cccgcttgaa accgtaccgg
     9181 ctgaaaatga gattgaaaga tttgttccaa catccgacca ttgaagaatt ggcaccgcat
     9241 gttttcccca tcgatgaaga ccgggaagat gaagtggtga cgggggaagt tgcgctgacc
     9301 ccgattcagc gttggatgtt tgagcagacg gattatccgg atcaatggaa catggccatt
     9361 gtcctgtacc ggaaacaagg atgggatgcc gacgtgttaa aaccggtttt ccatgcattg
     9421 gtgacccatc acgacgcctt gaggatgtcg tttaagcggg aagatcacca ggtgaaggca
     9481 tggaaccggg atgtggaagg ggaatttttc tccatccacg agtttgatgt caacagcgaa
     9541 gacctttcgg aagtgatgaa aagagaagcc aaccgtttgc atcaatcgct tcgcatccat
     9601 ggcgggccgt tgatccgcct ggggattttc cataccggcg aaggggatta cttgctgatc
     9661 attatccacc atttggtgat ggatgccgtt tcctggaggg tgctgtccga agatctccat
     9721 actgcgtacc ggcaacaatt ggacggggaa cccttggctt tgccgcaaaa aacgacttcg
     9781 tttcaatcat ggagccatca attgcaagag tttgcgaaca gtccggcgtt gcttgctgaa
     9841 attccgtatt ggaaagcgac cgaccgcctc caggttccaa aacttccggt cgataaaaaa
     9901 gaaacgtcgg attatgccaa tcagcatatc ggcatcgttt ggggacgcct cccgaaagag
     9961 gaaaccggtg acttgttgtc cggggcgcat cgcgcttacc agacggagat gaatgatttg
    10021 ttgttgtcgg gcttggtgat gaccttgaac agttggaccc atggcaaggt ggcggtccaa
    10081 ttggaagggc acggccggga ggaagtgatt gacggggtgg atttgaccag gaccgtcgga
    10141 tggtttacat ctatgtatcc ggtcgtgttt gaacaagatt ccaaaaatcc ggccgaagtc
    10201 attccgtatg tgaaagaagt cttgcggcgg gttcccaata aaggaatcgg atacgggatt
    10261 ctcaaatatt taacccgtcc cgaaaacaaa caagatcttt cgttccggct caaacctgag
    10321 atcaacttca actatcaagg ggagtttgtc cgggatgtgg agaaggagga catccaaatc
    10381 gtgtccctgc cggtgggaga aggggttcat cccctggctc agtggccgta taaactggat
    10441 ttcagtttgt ttgttgaaaa cggggaactg gtcacgctga ttcgctacca ccaaacgctg
    10501 tatcatcggg agacgattga acaactgaaa aacctctatc tccatcatct gaaaagaatt
    10561 gtggactttt gccgggaaga agtcttggtg aaataa
//
