BGC0002438 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002438 (Pithomyces chartarum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	51,164	High	sporidesmin A	other:other

BGC0002438 - Region 1 - NRPS

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Location: 1 - 51,164 nt. (total: 51,164 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

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transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 51,165
Label		BGC0002438

Tailoring functions

Oxidoreductases: oxygenase reductase

Spd10: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Spd13: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Spd3: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Spd8: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: aminotransferase halogenase methyltransferase sulfotransferase

Spd11: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Spd16: aminotransferase

smcogs: SMCOG1019: aminotransferase

Spd21: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Spd4: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Spd5: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

Spd7: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: ligase

Spd17: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002438.2	0.92	other (other)	sporidesmin A	Pithomyces chartarum
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002226.3	0.50	NRPS	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0000292.4	0.49	NRPS	acetylaranotin	Aspergillus terreus NIH2624
BGC0000372.5	0.48	NRPS	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0002208.3	0.45	NRPS	oxepinamide F	Aspergillus ustus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002438.2	0.99	other (other)	sporidesmin A	Pithomyces chartarum
BGC0002608.2	0.79	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002226.3	0.50	NRPS	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0000292.4	0.48	NRPS	acetylaranotin	Aspergillus terreus NIH2624
BGC0002321.3	0.46	other (other)	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 15413 - 51164:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Spd17: Trp - X

Search NORINE for peptide: strict or relaxed

AMP-binding (12..408): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAGVVGACAK
Nearest Stachelhaus code(s):: Trp DAGIVGACAK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1045..1433): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVQMHAIVVK
Nearest Stachelhaus code(s):: Pro DVQYVAHVVK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor