BGC0002452 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002452 (Streptomyces kitasatoensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	96,795	leucomycin	PKS	100%

BGC0002452 - Region 1 - T1PKS

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Location: 1 - 96,795 nt. (total: 96,795 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 96,796
Label		BGC0002452

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002452	0.91	Polyketide	leucomycin	Streptomyces kitasatoensis
BGC0000113	0.49	Polyketide	niddamycin	Streptomyces caelestis
BGC0000041	0.42	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273	0.34	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000996	0.32	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001244	0.32	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001504	0.32	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001124	0.32	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001276	0.32	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001163	0.31	Polyketide	1-heptadecene	Moorea producens 3L

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002452	1.00	Polyketide	leucomycin	Streptomyces kitasatoensis
BGC0000113	0.78	Polyketide	niddamycin	Streptomyces caelestis
BGC0000041	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.72	Other	amphotericin B	Streptomyces nodosus
BGC0000278	0.70	Polyketide	urdamycin	Streptomyces fradiae
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000996	0.66	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001244	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001504	0.65	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001124	0.65	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 78454:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - ccmal) + (ccmal) + (Me-ohmal - redemal) + (ohmxmal) + (ohmal)
Non-colinear ordering:: lcmA1 + lcmA2 + lcmA3 + lcmA4 + lcmA5

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

lcmA5

PKS_AT (559..859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 194.8
inactive: 100.8
Methoxymalonyl-CoA: 66.6
Methylmalonyl-CoA: 50.8
Propionyl-CoA: 28.8
Isobutyryl-CoA: 25.8
Acetyl-CoA: 21.0
Ethylmalonyl-CoA: 19.3
Benzoyl-CoA: 18.0
2-Methylbutyryl-CoA: 11.3
3-Methylbutyryl-CoA: 8.2
trans-1,2-CPDA: 6.2
fatty_acid: 5.0
CHC-CoA: 4.8

lcmA4

PKS_AT (569..859): mxmal

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 197.1
Ethylmalonyl-CoA: 195.9
Methylmalonyl-CoA: 190.3
trans-1,2-CPDA: 122.7
Malonyl-CoA: 110.3
2-Methylbutyryl-CoA: 109.1
Propionyl-CoA: 92.9
CHC-CoA: 86.1
Isobutyryl-CoA: 77.0
Benzoyl-CoA: 56.1
3-Methylbutyryl-CoA: 48.6
Acetyl-CoA: 48.0
fatty_acid: 39.0
inactive: 30.4

lcmA3

PKS_AT (573..884): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.9
Ethylmalonyl-CoA: 212.1
Methoxymalonyl-CoA: 179.4
2-Methylbutyryl-CoA: 154.4
trans-1,2-CPDA: 129.9
Propionyl-CoA: 121.7
CHC-CoA: 105.9
Malonyl-CoA: 105.6
Isobutyryl-CoA: 79.5
Benzoyl-CoA: 78.0
Acetyl-CoA: 38.7
fatty_acid: 38.4
3-Methylbutyryl-CoA: 37.8
inactive: 35.4

PKS_AT (2203..2501): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 233.3
Methylmalonyl-CoA: 203.6
Methoxymalonyl-CoA: 185.3
trans-1,2-CPDA: 156.8
2-Methylbutyryl-CoA: 151.0
Propionyl-CoA: 125.8
CHC-CoA: 101.9
Malonyl-CoA: 92.9
Isobutyryl-CoA: 74.7
Benzoyl-CoA: 62.9
Acetyl-CoA: 57.0
fatty_acid: 51.4
3-Methylbutyryl-CoA: 41.2
inactive: 24.7

lcmA2

PKS_AT (568..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.5
inactive: 106.4
Methoxymalonyl-CoA: 63.8
Methylmalonyl-CoA: 62.3
Propionyl-CoA: 37.2
Ethylmalonyl-CoA: 23.2
Acetyl-CoA: 22.3
fatty_acid: 21.1
Isobutyryl-CoA: 20.2
Benzoyl-CoA: 18.8
CHC-CoA: 18.5
trans-1,2-CPDA: 13.1
2-Methylbutyryl-CoA: 13.1
3-Methylbutyryl-CoA: 0.0

lcmA1

PKS_AT (541..833): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.7
inactive: 115.7
Methylmalonyl-CoA: 60.4
Methoxymalonyl-CoA: 59.7
Propionyl-CoA: 35.4
Isobutyryl-CoA: 22.3
Acetyl-CoA: 22.2
CHC-CoA: 21.2
fatty_acid: 17.8
Benzoyl-CoA: 17.7
Ethylmalonyl-CoA: 15.0
trans-1,2-CPDA: 12.4
2-Methylbutyryl-CoA: 11.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (1555..1848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.5
inactive: 117.8
Methylmalonyl-CoA: 61.9
Methoxymalonyl-CoA: 60.2
Propionyl-CoA: 35.5
Isobutyryl-CoA: 26.2
CHC-CoA: 20.3
fatty_acid: 19.1
Ethylmalonyl-CoA: 19.1
Acetyl-CoA: 18.4
Benzoyl-CoA: 14.2
trans-1,2-CPDA: 12.3
2-Methylbutyryl-CoA: 9.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3044..3338): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.8
inactive: 112.5
Methylmalonyl-CoA: 64.3
Methoxymalonyl-CoA: 58.2
Propionyl-CoA: 38.4
Isobutyryl-CoA: 29.5
Acetyl-CoA: 22.3
CHC-CoA: 20.2
fatty_acid: 15.8
Benzoyl-CoA: 15.8
Ethylmalonyl-CoA: 15.2
trans-1,2-CPDA: 12.9
2-Methylbutyryl-CoA: 10.6
3-Methylbutyryl-CoA: 0.0