BGC0002452: leucomycin biosynthetic gene cluster from Streptomyces kitasatoensis
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Location: 1 - 96,795 nt. (total: 96,795 nt).
This entry is originally from NCBI GenBank LC496468.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002452
Short description leucomycin biosynthetic gene cluster from Streptomyces kitasatoensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: LC496468.1
Compounds
  • leucomycin
Species Streptomyces kitasatoensis [taxonomy]
References
Chemical products information
leucomycin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBM96620.1
 111 - 1598 (-) methyltransferase
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  • BBM96621.1
 1703 - 2611 (-) homocysteine S-methyltransferase
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  • BBM96622.1
 2667 - 3590 (-) monooxygenase
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  • BBM96623.1
 3838 - 4032 (+) hypothetical protein
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  • BBM96624.1
 4044 - 4502 (-) hypotheticl protein
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  • BBM96625.1
 4698 - 5117 (-) hypothetical protein
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  • BBM96626.1
 5092 - 6318 (-) bldA-regulated nucleotide binding protein
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  • BBM96627.1
 6343 - 6747 (-) hypothetical protein
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  • BBM96628.1
 6876 - 7484 (-) TetR-family transcriptional regulator
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  • BBM96629.1
 7607 - 7792 (+) hypothetical protein
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  • BBM96630.1
  • macR
 7867 - 8796 (-) 23S rRNA methyltransferase
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  • BBM96631.1
  • lcmN
 9330 - 10985 (+) ABC transporter ATP-binding protein
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  • BBM96632.1
  • lcmK
 11162 - 12358 (+) 3-O-acetyltransferase
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  • BBM96633.1
  • lcmH
 12402 - 13067 (+) O-methyltransferase
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  • BBM96634.1
  • lcmBIII
 13134 - 14408 (-) mycaminosyl transferase
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  • BBM96635.1
  • lcmBII
 14624 - 15853 (-) NDP-hexose-3,4-isomerase
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  • BBM96636.1
  • lcmBI
 16021 - 16734 (-) NDP-aminohexose N-dimethyltransferase
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  • BBM96637.1
  • lcmA5
 16734 - 22295 (-) modular polyketide synthase
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  • BBM96638.1
  • lcmA4
 22368 - 27035 (-) modular polyketide synthase
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  • BBM96639.1
  • lcmA3
 27094 - 39249 (-) modular polyketide synthase
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  • BBM96640.1
  • lcmA2
 39356 - 45229 (-) modular polyketide synthase
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  • BBM96641.1
  • lcmA1
 45330 - 58454 (-) modular polyketide synthase
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  • BBM96642.1
  • lcmJ
 58613 - 59671 (-) ketoreductase
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  • BBM96643.1
  • lcmI
 60093 - 61301 (+) cytochrome P450 hydroxylase
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  • BBM96644.1
  • lcmCI
 61292 - 61849 (+) NDP-hexose isomerase
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  • BBM96645.1
  • lcmCII
 61846 - 63012 (+) NDP-hexose aminotransferase
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  • BBM96646.1
  • lcmCIII
 63009 - 63917 (+) glucose-1-phosphate thymidyltransferase
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  • BBM96647.1
  • lcmCIV
 63901 - 64905 (+) dTDP-glucose 4,6-dehydratase
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  • BBM96648.1
  • lcmCV
 64981 - 66411 (+) NDP-hexose 2,3-dehydratase
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  • BBM96649.1
  • lcmL
 66662 - 67771 (-) 4''-O-acyltransferase
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  • BBM96650.1
  • lcmRI
 68207 - 69361 (+) regulator for expression of lcm cluster
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  • BBM96651.1
  • lcmRII
 69406 - 71358 (-) CdaR-family transcriptional regulator
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  • BBM96652.1
  • lcmCVI
 71556 - 72638 (-) transaldolase
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  • BBM96653.1
  • lcmCVII
 72680 - 73288 (-) NDP-hexose 3,5-epimerase
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  • BBM96654.1
  • lcmCVIII
 73510 - 74724 (-) mycarosyl transferase
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  • BBM96655.1
  • lcmD
 75051 - 75941 (+) 3-hydroxyacyl-CoA dehydrogenase
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  • BBM96656.1
  • lcmE
 75938 - 76255 (+) acyl carrier protein
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  • BBM96657.1
  • lcmF
 76248 - 77375 (+) acyl-CoA dehydrogenase
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  • BBM96658.1
  • lcmG
 77423 - 78523 (+) hydrolase
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  • BBM96659.1
  • lcmCIX
 78520 - 79752 (+) NDP-hexose 3-C-methyltransferase
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  • BBM96660.1
  • lcmCX
 79866 - 80864 (-) dTDP-4-keto-6-deoxy-L-hexose 2,3-reductase
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  • BBM96661.1
  • lcmCXI
 80861 - 81865 (-) dTDP-4-keto-6-deoxy-L-hexose 4-reductase
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  • BBM96662.1
 82242 - 82610 (+) isomerase
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  • BBM96663.1
 82600 - 83646 (-) DNA-binding protein
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  • BBM96664.1
 83720 - 86323 (-) hypothetical protein
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  • BBM96665.1
 86541 - 87008 (+) transcriptional regulator
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  • BBM96666.1
 87096 - 89003 (-) sulfate adenylyltransferase, large subunit
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  • BBM96667.1
 89003 - 89938 (-) sulfate adenylyltransferase, small subunit
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  • BBM96668.1
 89935 - 90795 (-) inositol monophosphatase
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  • BBM96669.1
 91080 - 91871 (+) thioesterase
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  • BBM96670.1
 91880 - 92926 (+) hypothetical protein
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Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Entry added
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