BGC0002453: ansaseomycin A biosynthetic gene cluster from Streptomyces seoulensis
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Location: 1 - 76,762 nt. (total: 76,762 nt).
This entry is originally from NCBI GenBank MK599163.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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TTA codons
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Gene details
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NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0002453
Short description | ansaseomycin A biosynthetic gene cluster from Streptomyces seoulensis
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)

Loci
MK599163.1
1 - 76762
via Heterologous expression
Compounds

- ansaseomycin A
- ansaseomycin B

Species Streptomyces seoulensis [taxonomy]
References

- [1] Heterologous Expression of a Cryptic Giant Type I PKS Gene Cluster Leads to the Production of Ansaseomycin. Liu SH et al., Org Lett (2019) PMID:31033301

Chemical products information
ansaseomycin A Evidence:
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Chemical database entries
NPAtlas
ansaseomycin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
QES95459.1 | 1 - 588 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
QES95460.1 | 823 - 3828 (+) | ATP-dependent helicase |  |  | copy AA seq copy Nt seq
QES95461.1 | 3828 - 6593 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
QES95462.1 | 6727 - 7986 (-) | MFS transporter |  |  | copy AA seq copy Nt seq
QES95463.1 | 8250 - 8648 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
QES95464.1 | 8645 - 9676 (+) | aminotransferase |  |  | copy AA seq copy Nt seq
QES95465.1 | 9685 - 10323 (-) | SAM-dependent methyltransferase |  |  | copy AA seq copy Nt seq
QES95466.1 | 10482 - 11420 (-) | MerR family transcriptional regulator |  |  | copy AA seq copy Nt seq
QES95467.1 | 11539 - 12237 (-) | kinase |  |  | copy AA seq copy Nt seq
QES95468.1 | 12413 - 14023 (-) | 3-(3-hydroxyphenyl)propionate hydroxylase |  |  | copy AA seq copy Nt seq
QES95469.1 | 14029 - 14463 (-) | aminodehydroquinate dehydratase |  |  | copy AA seq copy Nt seq
QES95470.1 | 14671 - 15852 (+) | AHBA synthase |  |  | copy AA seq copy Nt seq
QES95471.1 | 15861 - 16940 (+) | oxidoreductase |  |  | copy AA seq copy Nt seq
QES95472.1 | 16937 - 17623 (+) | phosphatase |  |  | copy AA seq copy Nt seq
QES95473.1 | 17620 - 18642 (+) | aminodehydroquinate synthase |  |  | copy AA seq copy Nt seq
QES95474.1 | 18874 - 35127 (+) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
QES95475.1 | 35153 - 40702 (+) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
QES95476.1 | 40727 - 46234 (+) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
QES95477.1 | 46293 - 49637 (+) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
QES95478.1 | 49700 - 55246 (+) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
QES95479.1 | 55271 - 60592 (+) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
QES95480.1 | 60620 - 61357 (+) | amide synthase |  |  | copy AA seq copy Nt seq
QES95481.1 | 61508 - 63031 (+) | FAD-linked oxidase |  |  | copy AA seq copy Nt seq
QES95482.1 | 63028 - 63792 (+) | type II thioesterase |  |  | copy AA seq copy Nt seq
QES95483.1 | 63798 - 65078 (+) | DAHP synthase |  |  | copy AA seq copy Nt seq
QES95484.1 | 65254 - 66156 (+) | dehydrogenase |  |  | copy AA seq copy Nt seq
QES95485.1 | 66153 - 67133 (+) | 2-oxoisovalerate |  |  | copy AA seq copy Nt seq
QES95486.1 | 67130 - 67408 (+) | dihydrolipoamide succinyltransferase |  |  | copy AA seq copy Nt seq
QES95487.1 | 67401 - 67646 (+) | acyl carrier protein |  |  | copy AA seq copy Nt seq
QES95488.1 | 67646 - 68569 (+) | 3-oxoacyl-(acyl-carrier-protein)-synthase III |  |  | copy AA seq copy Nt seq
QES95489.1 | 68627 - 69778 (+) | alcohol dehydrogenase BadC |  |  | copy AA seq copy Nt seq
QES95490.1 | 69805 - 72567 (+) | LuxR-family transcriptional regulator |  |  | copy AA seq copy Nt seq
QES95491.1 | 72683 - 73312 (-) | nitroreductase |  |  | copy AA seq copy Nt seq
QES95492.1 | 73406 - 74278 (-) | shikimate/quinate dehydrogenase |  |  | copy AA seq copy Nt seq
QES95493.1 | 74362 - 75135 (-) | putative discrete thioesterase |  |  | copy AA seq copy Nt seq
QES95494.1 | 75458 - 76762 (+) | 3-oxoadipate enol-lactonase |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Entry added

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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