LOCUS       BGC0002458              5083 bp    DNA     linear   BCT 12-MAR-2021
DEFINITION  Streptacidiphilus griseoplanus JCM 4300 DNA, containing alazopeptin
            biosynthetic gene cluster 2.
ACCESSION   BGC0002458
VERSION     BGC0002458
KEYWORDS    .
SOURCE      Streptacidiphilus griseoplanus
  ORGANISM  Streptacidiphilus griseoplanus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptacidiphilus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:45:59
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..5083
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002458"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5083
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1437)
                     /gene="azpD"
     CDS             complement(1..1437)
                     /codon_start=1
                     /gene="azpD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 196.3; E-value: 1.5e-59)"
                     /gene_kind="biosynthetic-additional"
                     /product="nitrosuccinate lyase"
                     /protein_id="BCN13466.1"
                     /transl_table=11
                     /translation="MSPQPGTEQPDVLCDAGLLSPVRAGTPVEAAVCDRAWLQAMLDAE
                     AALVRTQAALGTVPKPAADSISAAARAERLDLRTLALASRETANPVVGLVQAFTREVAA
                     DDPSAAEYVHRGSTSQDILDTGAMLVCARAVRIIRADLSRAAAALQELAARHRDTPMAG
                     RTLALQAVPTTFGLKAAGWRQLLLDADVRLDRVADGGLPVSLGGAAGTLAGYLEYARID
                     GPAGEFDEAGYVRRLVSGFAAGTGLAVPALPWHSLRTPIADLAAALAFTAAALGKLAVD
                     VQTLSRTEIAEVSEPSAAGRGASSAMPHKRNPVLATLIRSAALQVPCLATGLTQCLLAE
                     DERSAGGWHAEWQLLREVLRLTGGAAHTAVELAEGLAVHPQRMRANLDLTAGQIVSERL
                     SAALAPRLGKAAAKELLSEASAEAARSGLPLSEVMLRLPGAAGLFTATELNGLCDPARY
                     TGAAGALVEQTLSEPDDASG"
     gene            complement(1434..3395)
                     /gene="azpE"
     CDS             complement(1434..3395)
                     /codon_start=1
                     /gene="azpE"
                     /product="aspartate monooxygenase"
                     /protein_id="BCN13467.1"
                     /transl_table=11
                     /translation="MTTEPLAICLIGAGPRGLSVLERLIARACVAPTTPRATVHVVDPF
                     PAGAGAVWRTDQSQELLMNTVASQITVFTDDSVRIEGPVVPGPALYDWAAAVARDPQRP
                     ADDPVLREAQRLGPDSYPTRAFYGAYLRAMFQRVCAQAPVGFDVVVHRTRAVALWDRAG
                     DPGRRQTVLLEDGTRLDAIAAVVLSQGHVPASLTPAERELSEQAAAHGLTYLPPANPAD
                     LDLSGIAPGEPVVLRGLGLNFFDHMALLTAGRGGSFVRRAGRLVYRPSGREPQLYAGSR
                     RGIPYHARGENQKGASGRYTPRLLTADFVARLRARAQAGEPAGFGTDVWPLIAREVESV
                     YYGCLLDTRGRRADREPFVELYLAAPDEEHRCEILGAYGIAREDRWDWDRLAFPHEGIE
                     FQHRGQFRSWLLGYLARDVEQAMAGNVHGPVKAALDVLRDLRNEVRLAVDHGGLEGNSH
                     RDDLDGWYTPLNAFLSIGPPPSRIEQMTALIEAGVLELLGPRLHVHVDGQRPAFVAGSR
                     LVPGPPVRATTLIEARLPEPDLRRTADPLMRYLRDTGQAVPFRIDGACGTSHETGGMAV
                     TERPYRLVDAQGLAHPRRFAHGVPTEAVHWVTAAGIRPGVDSVTLGDSDAIAQAVLHLD
                     GHGDARAAEAPDSMGAHI"
     gene            3665..5083
                     /gene="azpR"
     CDS             3665..5083
                     /NRPS_PKS="Domain: Aminotran_1_2 (125-419). E-value:
                     2.2e-23. Score: 74.8. Matches aSDomain:
                     nrpspksdomains_azpR_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="azpR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 272.9; E-value:
                     7.2e-83)"
                     /gene_kind="biosynthetic-additional"
                     /product="DNA-binding domain/PLP-dependent
                     aminotransferase"
                     /protein_id="BCN13468.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1e-24, bitscore:
                     75.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEWSTSSLDLHLDADLSRRHGRSQRLAAAVRAAIETGRLPPGA
                     RMPSTRSMAQDLQVARGTVTSAYEQLATAGYLEVVHGSGTRVADLRARPDAREEGTPPA
                     AGPAPRWNLRPGLPDVTLFPRTAWVTATQRVLREAPAEALDYGDPRGRPELRAALAHYL
                     GRARGVVAQPERIVVCHGYTQALGLLAKVVAGLKTPTMAFEDPSYPLFREIVRTAGLAT
                     VSAEVDEEGLRVDSIGPARAVVVTPMHQYPLGVALSRARREQLIAWARAADGVVIEDDY
                     DGEFQFHPKPSGALQALDPERVVYAGTTSKTLAPGLRLAWLVLPRDWVEPVAVAKRIAD
                     QHSAALGQMVLAQLISSGAYDRHIRRCRTRYRDRRQRLAAILAEKAPSTEIVGRSAGLH
                     ALVRWSPEGPTEREVLQAARRESLALSALGDYWAAEGPHAPGLVVGYATPPQHGYTGAL
                     EALTRALDRAFGRR"
     aSDomain        4040..4921
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_azpR_Aminotran_1_2.1"
                     /evalue="2.20E-23"
                     /label="azpR_Aminotran_1_2.1"
                     /locus_tag="azpR"
                     /protein_end="419"
                     /protein_start="125"
                     /score="74.8"
                     /tool="antismash"
                     /translation="TAWVTATQRVLREAPAEALDYGDPRGRPELRAALAHYLGRARGVV
                     AQPERIVVCHGYTQALGLLAKVVAGLKTPTMAFEDPSYPLFREIVRTAGLATVSAEVDE
                     EGLRVDSIGPARAVVVTPMHQYPLGVALSRARREQLIAWARAADGVVIEDDYDGEFQFH
                     PKPSGALQALDPERVVYAGTTSKTLAPGLRLAWLVLPRDWVEPVAVAKRIADQHSAALG
                     QMVLAQLISSGAYDRHIRRCRTRYRDRRQRLAAILAEKAPSTEIVGRSAGLHALVRWSP
                     EGPTEREVLQAAR"
ORIGIN
        1 tcaccccgag gcgtcgtccg gctccgacag cgtctgctcc accagcgccc ccgcggcccc
       61 ggtgtaccgc gccgggtcgc agagcccgtt cagctcggtg gcggtgaaca gaccggcggc
      121 cccgggcagc cgcagcatga cctccgacag cggcagcccc gagcgtgccg cctcggcgga
      181 cgcctcgctc agcagctcct tggccgcggc cttgcccagg cggggcgcca gggccgcact
      241 cagccgctcc gagacgatct gccccgcggt gaggtccaga ttggcgcgca tccgctgcgg
      301 atggaccgcc agcccctccg ccagctccac cgccgtgtgg gcggcaccgc ccgtcagccg
      361 caggacctcc cgcagcagct gccactccgc gtgccagccg cccgccgacc gctcgtcctc
      421 ggccagcaga cactgcgtca gacccgtcgc cagacagggg acctggagcg ccgcactgcg
      481 gatgagcgtg gccagcaccg ggttgcgctt gtgcggcatg gcggacgagg ccccccggcc
      541 ggctgcggac ggctccgaga cctccgcgat ctcggtccgg gagagcgtct ggacgtcgac
      601 cgccagcttg cccagcgccg cggcggtgaa ggccagcgcg gcggccaggt cggcgatcgg
      661 ggtgcgcagc gagtgccagg gcagcgcggg tacggcgagc ccggtccccg cggcgaagcc
      721 ggacaccagc cgccgtacgt agccggcctc gtcgaactcc ccggcgggcc cgtcgatccg
      781 cgcgtactcc agatagcccg ccagggtgcc cgccgctccg ccgagggaga ccggcaggcc
      841 cccgtcggcg acacggtcca gccggacgtc cgcgtccagc agcagctgcc gccaccccgc
      901 ggccttgagc ccgaaggtgg tggggacggc ctgcagcgcc agggtccgcc cggccatcgg
      961 ggtgtcgcgg tggcgggccg ccagctcctg cagtgcggcc gccgcacggg agaggtcggc
     1021 gcggatgatc cgcaccgccc gcgcgcacac cagcatcgcc ccggtgtcca ggatgtcctg
     1081 gctggtggag ccgcggtgca cgtactccgc cgccgagggg tcgtccgcgg ccacctccct
     1141 ggtgaacgcc tgcaccaagc ccaccacggg attggcggtc tcccgcgacg ccagggccag
     1201 cgtccgcagg tccaggcgtt ccgcccgggc cgccgcgctg atgctgtccg cggccggctt
     1261 ggggacggtg cccagcgcgg cctgcgtgcg gaccagcgcg gcctccgcgt ccagcatggc
     1321 ctgcagccag gcccggtcgc agacggccgc ctccaccggg gtcccggccc ggaccgggga
     1381 gagcagaccg gcgtcgcaca ggacgtccgg ctgctccgta ccgggttgcg gactcatatg
     1441 tgtgctccca tgctgtccgg ggcctcggcg gcccgtgcgt cgccgtgccc gtcgaggtgc
     1501 agcacggcct gtgctatcgc gtcggagtcc ccgagggtca ccgagtcgac cccggggcgg
     1561 atgcccgcgg cggtcaccca gtgcaccgcc tcggtgggca ccccgtgggc gaaccgccgg
     1621 gggtgcgcga ggccctgcgc gtccaccagc cggtacggcc gctccgtcac cgccatccct
     1681 ccggtctcgt ggctcgttcc gcaggcgccg tcgatccgga acgggaccgc ctgtcccgtg
     1741 tcgcggaggt agcgcatcag ggggtcggcg gtgcgccgca gatcgggttc cggcagccgt
     1801 gcctcgatca gtgtggtggc gcggaccggg ggacccggca ccagccggct gccggccacg
     1861 aacgccggcc gctgcccgtc cacatggacg tgcagccgcg ggccgaggag ctccagcact
     1921 ccggcctcga tcagcgcggt catctgctcg atccgcgacg gcggcggccc gatcgacagg
     1981 aacgcgttca ggggtgtgta ccagccgtcg aggtcgtccc gatgggagtt gccctccagc
     2041 ccgccgtggt cgaccgccag ccgtacctcg ttgcgcaggt cgcgcagcac atcgagcgcc
     2101 gccttgaccg gcccgtggac attgcccgcc atggcctgtt cgacgtcgcg ggcgagatag
     2161 cccagcagcc aggagcggaa ctggccccgg tgctggaact cgatcccctc gtgcgggaag
     2221 gccagccggt cccagtccca gcggtcctcc ctggcgatcc cgtaggcgcc gaggatctca
     2281 cagcggtgct cctcgtccgg cgccgccagg tacagctcca cgaagggctc ccggtcggcc
     2341 cggcggccgc gggtgtccag caggcagccg tagtagacgc tctccacctc acgggcgatc
     2401 agcggccaga cgtcggtgcc gaagccggcc ggctccccgg cctgggcccg ggcacgcagc
     2461 ctcgccacga agtccgcggt gagcagccgc ggggtgtacc ggcccgacgc ccccttctgg
     2521 ttctcaccgc gggcgtggta cgggatgccc cgccgtgagc cggcgtacaa ctgcggctcc
     2581 cgccccgacg gccggtacac cagccggccc gcccggcgga cgaagctgcc gccgcggccc
     2641 gcggtgagca gtgccatgtg gtcgaagaag ttcaggccga gaccccgcag gaccaccggt
     2701 tcaccggggg cgatgccgga gaggtcgagg tcggccgggt tggcgggcgg gagataggtg
     2761 aggccgtgcg cggcggcctg ttcggacagc tcccgttcgg cgggcgtgag ggacgccggg
     2821 acgtgcccct gcgacaggac cacggcggcg atcgcgtcca gccgggtgcc gtcctccagc
     2881 agcacggtct gccgtcggcc gggatccccg gcccggtccc agagggcgac cgcacgggtg
     2941 cggtggacca cgacgtcgaa gccgacgggg gcctgtgcgc agacccgctg gaacatggcc
     3001 cgcagatagg cgccgtagaa cgcccgggtg ggatagctgt ccgggcccag ccgctgcgcc
     3061 tcccggagga ccgggtcgtc cgcgggccgc tgcgggtcgc gggcgacggc ggcggcccag
     3121 tcgtacaggg ccggccccgg cacgaccggc ccctcgatcc gtacgctgtc gtcggtgaag
     3181 acggtgatct gggaggccac cgtgttcatc agcagttcct gggactggtc cgtgcgccag
     3241 acggccccgg cccccgccgg gaaggggtcg acgacatgca cggtggcccg cggtgtcgtg
     3301 ggcgccacgc aggcgcgggc gatcaggcgc tccagtacgg acagcccacg cgggccggcc
     3361 ccgatcaggc agatggcgag aggttcggtg gtcatggaag agctcaatcc cccttgaaca
     3421 gttgcctgcc gagcacctgc agacgtcgtc gggcgaccgc cgcgatcgtc atgcacgcgt
     3481 cgtctcctgt gtccacggct cacggtaggt gcgcgcggca gccacgatcg gtccacttgg
     3541 cgaccaactg aatggaccag ttcggcggcc gctgcccgct ttccgcaggt cgcagacgtg
     3601 ctgcggtcca ccggcggcca tcccgcccgc cggccggcac ccggcccggg gctagggtca
     3661 ccccatgtcc agtgaatggt ccacctcctc gctcgatctc catctggatg cggacctgag
     3721 ccggcggcac ggccggtcgc agcggctcgc ggcggcggtc cgcgcggcca tcgagaccgg
     3781 acggctcccc ccgggggcgc ggatgccctc cacccgcagc atggcgcagg acctgcaggt
     3841 cgccagaggt acggtgacca gcgcctatga gcaactcgcc accgccggct atctggaggt
     3901 cgtccacggc tcgggcaccc gggtggcgga cctgagggcc cgccctgacg cccgggagga
     3961 ggggacgccc cccgccgccg ggccggcgcc ccggtggaac ctgcggccgg ggctcccgga
     4021 cgtcaccctc ttcccgcgga ccgcctgggt caccgcgacg cagcgggtgc tcagggaggc
     4081 gcccgcggag gccctggact acggcgaccc ccgggggcgg cccgaactgc gcgccgctct
     4141 ggcgcactat ctgggccgcg cccggggtgt ggtcgcacag ccggagcgga tcgtcgtctg
     4201 ccacggctac acccaggcgc tgggcctgct ggccaaggtg gtcgccggcc tcaagacccc
     4261 gaccatggcc ttcgaggacc cctcctaccc cctgttccgc gagatcgtcc gcaccgcggg
     4321 cctggcgacg gtgtccgcgg aggtcgacga ggagggcctg cgggtggact ccatcggccc
     4381 cgcgcgggcg gtggtggtca cacccatgca ccagtacccg ctcggggtgg cgctctcccg
     4441 cgcacgacgg gagcagctca tcgcctgggc acgcgcggcc gacggggtcg tcatcgagga
     4501 cgactacgac ggcgagttcc agttccaccc caagcccagc ggcgccctgc aggcactcga
     4561 ccccgagcgg gtggtctacg ccgggacgac cagcaagacc ctggcgccgg gcctgcggct
     4621 ggcctggctc gtcctgcccc gcgactgggt ggagccggtg gcggtggcca agcgcatcgc
     4681 cgaccagcac tcggcggcgc tgggccagat ggtcctggcc cagctgatct cctccggcgc
     4741 gtacgacagg cacatccgcc gctgccggac ccgttaccgg gaccgcaggc agcggctggc
     4801 cgcgatcctg gccgagaagg caccgtcgac cgagatcgtg ggacgcagcg cgggcctgca
     4861 cgccctggtc cgctggtccc cggaggggcc gaccgagcgt gaggtgctgc aggccgcccg
     4921 gcgggagtcg ctggcgctga gtgcgctggg cgactactgg gcggcggagg ggcctcacgc
     4981 accggggctg gtggtcggct atgcgacgcc gccgcagcac gggtacacgg gtgcgctgga
     5041 ggcgctgacc cgggcgctcg accgggcctt cggccggcgg tga
//
