BGC0002461 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002461 (Streptomyces aureus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	54,031	High	aureonuclemycin	PKS

BGC0002461 - Region 1 - T2PKS

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Location: 1 - 54,031 nt. (total: 54,031 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 54,032
Label		BGC0002461

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AYU66237.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AYU66241.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AYU66242.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AYU66245.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AYU66246.1: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

AYU66248.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AYU66250.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AYU66256.1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

AYU66263.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AYU66265.1: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

AYU66269.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase glycosyltransferase transferase

AYU66243.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

AYU66258.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AYU66260.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AYU66262.1: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

AYU66266.1: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: esterase

AYU66232.1: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase dehydratase

AYU66238.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

AYU66244.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

AYU66251.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

AYU66259.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: ligase synthase

AYU66233.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AYU66234.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AYU66239.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

AYU66268.1: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002461.2	0.95	PKS	aureonuclemycin	Streptomyces aureus
BGC0000231.5	0.78	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.69	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.65	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002193.2	0.63	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001723.5	0.62	PKS	oviedomycin	Streptomyces antibioticus
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001197.5	0.59	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000272.3	0.59	PKS	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002461.2	0.99	PKS	aureonuclemycin	Streptomyces aureus
BGC0000231.5	0.78	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.69	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.65	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000278.3	0.64	PKS	urdamycin	Streptomyces fradiae
BGC0002193.2	0.63	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001723.5	0.62	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.59	PKS	spore pigment	Streptomyces collinus
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

AYU66239.1: X

AMP-binding (20..418): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PMNYAGGPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 48199
Starter unit(s):: malonamyl-CoA (Score: 470.0; E-value: 1.1e-163)
Malonyl elongations:: 8|9 (Score: 686.5; E-value: 2.2e-209)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 760 Da
malonamyl-CoA_9: 802 Da

AYU66231.1: CYC C5-C14/C3-C16 (Score: 450.7; E-value: 3.3e-138)
AYU66233.1: KS (Score: 782.7; E-value: 1.8e-238)
AYU66234.1: CLF 8|9 (Score: 686.5; E-value: 2.2e-209)
AYU66235.1: ACP (Score: 116.7; E-value: 8.1e-37)
AYU66236.1: CYC C1-C18|C2-C19 (Score: 219.9; E-value: 2.5e-68)
AYU66237.1: KR C9 (Score: 465.9; E-value: 8e-143)
AYU66238.1: CYC C7-C12 (Score: 453.1; E-value: 9.1e-139)
AYU66239.1: LIG (Score: 580.0; E-value: 8.5e-177); LIG ELQ83297.1_Oxytetracycline_malonamyl-CoA (Score: 470.0; E-value: 1.1e-163)
AYU66241.1: KR (Score: 132.1; E-value: 6.5e-41)
AYU66242.1: OXY (Score: 174.0; E-value: 1.3e-53)
AYU66245.1: OXY (Score: 434.6; E-value: 1.2e-132)
AYU66246.1: KR (Score: 53.9; E-value: 4.6e-17)
AYU66248.1: KR (Score: 151.8; E-value: 6.5e-47)
AYU66250.1: OXY (Score: 314.5; E-value: 3.2e-96)
AYU66258.1: GT (Score: 353.7; E-value: 4e-108)
AYU66259.1: CYC C7-C12 (Score: 187.6; E-value: 5.6e-58)
AYU66260.1: GT (Score: 330.8; E-value: 3.4e-101)
AYU66263.1: KR (Score: 215.7; E-value: 2e-66)