LOCUS       BGC0002462              6717 bp    DNA     linear   BCT 07-APR-2021
DEFINITION  Streptomyces kaniharaensis strain SF-557 hypothetical protein,
            short-chain dehydrogenase (cofA), SAICAR synthetase (cofB), GntR
            family transcriptional regulator, hypothetical protein, and major
            facilitator superfamily (MFS) transporter (cofC) genes, complete
            cds; formycin A biosynthetic gene cluster, complete sequence; and
            hypothetical protein, ribulose-phosphate 3-epimerase, and
            hypothetical protein genes, complete cds.
ACCESSION   BGC0002462
VERSION     BGC0002462
KEYWORDS    .
SOURCE      Streptomyces kaniharaensis
  ORGANISM  Streptomyces kaniharaensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:46:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6717
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..6717
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002462"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6717
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(4..798)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 130.1; E-value: 1.8e-39)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf1"
                     /product="hypothetical protein"
                     /protein_id="QTK22478.1"
                     /transl_table=11
                     /translation="MADGYRLLACDLDGTLLDSSGVLPGAVSDALGRAVAAGLAVAVVT
                     ARPPRDVPAEIRSGIPPSAYWAHGNGALVFRPGERRPSRQLVFDAAALHRVAAILGKAH
                     PDWALAFDLLDGTVVQPGFPEELARHWSGVEWRGAVEPARPVVKVLACPFAPFGAELVD
                     AVQGLVGSDAEVTASGRHFLELGPRGTGKHGVLAWIAADLGLHPAETVAVGDGLNDCGM
                     LTLAGLGAAPANAPDTVRRAADRLLPSNDDHAVAHLVDQLLA"
     CDS             complement(791..1213)
                     /codon_start=1
                     /note="orf2"
                     /product="hypothetical protein"
                     /protein_id="QTK22479.1"
                     /transl_table=11
                     /translation="MESHTGTAGICTPEAQWDEGRGEFSVDLLPDADGPGAAVMSFRTV
                     AWVGLGASGAVTSVDVHDIPVQVSDRIPRVEGDDVIGCAVVDTQWLWVPLGTGPTARRH
                     AGRADVEAVVTGAGLARLTLRFLGEAMKKPRRADHG"
     gene            complement(1248..1949)
                     /gene="cofA"
     CDS             complement(1248..1949)
                     /codon_start=1
                     /gene="cofA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     132.3; E-value: 3.4e-40)"
                     /gene_kind="biosynthetic-additional"
                     /product="short-chain dehydrogenase"
                     /protein_id="QTK22480.1"
                     /transl_table=11
                     /translation="MGEPAAPPLALVTGSNRGTGRAVRSRLIADGYTVRCLNRSPCADH
                     DDPVTVDFGDPAAVARAAEQVLADAPRLDLLVVNAVTRGFGAVADVTAQDWDEAVAVNL
                     TAPVRLVQAALPLLRRAQGHIVLMGSHAGSRPFEGGVAYCATKAALKQVAEVLLMEERR
                     HGVRTTLLSPGAIRNFDDDHSAYKMSVESVAEVVSWAASTPRDTVLGEIELRPGRLDTP
                     PVVGLDRLQHV"
     gene            complement(1942..2637)
                     /gene="cofB"
     CDS             complement(1942..2637)
                     /codon_start=1
                     /gene="cofB"
                     /product="SAICAR synthetase"
                     /protein_id="QTK22481.1"
                     /transl_table=11
                     /translation="MTSRTPDIEGRSKRLWHLDEGLCLIEMIPSLRSFTYDRDELVDGT
                     AELRLDFFEYVSARLAERGVYTVFRERVGPVSYLADYRPAPPFEVIVKNRATGSTIRKY
                     PGLFEEGQVLDRPVVKFDYRVDPEDQPIGEDYLRLLGVDVEHHRQVALDCNAVLRELLA
                     PLDLWDFCLVIAPDDKHGLVVNSEISPDCMRLKSADGRPYDKDMFRQGAGREDILARWA
                     ELISMVSGG"
     CDS             2889..4247
                     /NRPS_PKS="Domain: Aminotran_1_2 (157-435). E-value:
                     2.5e-14. Score: 45.0. Matches aSDomain:
                     nrpspksdomains_QTK22482.1_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 212; E-value: 2.3e-64)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf3"
                     /product="GntR family transcriptional regulator"
                     /protein_id="QTK22482.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.6e-15, bitscore:
                     44.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFVMPEQHRIRGRRAAEIAADVEQAVAAGHLAPGSPLPPLRRLAT
                     ELGVNPNTAAAAYRLLRDRGVIETGGRRGTRVSPRPTHIARAHLHFEVPDGVRDLTDGN
                     PDPGLLPPLADALAFAAGEQLRDPVLYGRPAVDPGLLAIARREFAADGLPGETTAVTSG
                     ALDAIERVLQTRLRPGDLVAVEDPGWGSLHDLLPALGLRMTGIGVDDEGPLPQDVAVAL
                     AAGAAALVVTSRAQNPTGATVGPGRAAELRAVLANRPDVLLIEDDFGHAIADTPYHPVC
                     AANGRPVVRHWTVVRSVTKLLGPDMRLAVLTGDPDTVDRLRGRQRLGTGWVSHVLQRAA
                     ARLLADESVDRARVAAHYTERRGALIRALAAEGVPARGRSGFNVWIPVHSETSAVVALL
                     QRGWAVAPGAPFRLRSGPGLRLTVSGLALDELPALAADVAAALRVDPERGRLT"
     aSDomain        3360..4193
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QTK22482.1_Aminotran_1_2.1"
                     /evalue="2.50E-14"
                     /label="QTK22482.1_Aminotran_1_2.1"
                     /locus_tag="QTK22482.1"
                     /protein_end="435"
                     /protein_start="157"
                     /score="45.0"
                     /tool="antismash"
                     /translation="TAVTSGALDAIERVLQTRLRPGDLVAVEDPGWGSLHDLLPALGLR
                     MTGIGVDDEGPLPQDVAVALAAGAAALVVTSRAQNPTGATVGPGRAAELRAVLANRPDV
                     LLIEDDFGHAIADTPYHPVCAANGRPVVRHWTVVRSVTKLLGPDMRLAVLTGDPDTVDR
                     LRGRQRLGTGWVSHVLQRAAARLLADESVDRARVAAHYTERRGALIRALAAEGVPARGR
                     SGFNVWIPVHSETSAVVALLQRGWAVAPGAPFRLRSGPGLRLTVSGLALDELPALA"
     misc_feature    3402..3404
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             4456..5463
                     /codon_start=1
                     /note="orf4"
                     /product="hypothetical protein"
                     /protein_id="QTK22483.1"
                     /transl_table=11
                     /translation="MTSIFDRLYDHTLADLGALDAPYDTGHLSRTAALAGRIAEESGLA
                     AGTARCAAHLYHRFRLPGARDAPAGTRDSALDFLTRSGVPGELHRDLLTVVGPGSPAAE
                     TPYRAAVLDAERIDAMGAAGLQRALTGEGLPWHPDGPAAGRPRPAPPELYEELVRAERE
                     LLTEPARRLAADRMDLVHRLAADYRTEAELGRLPGEPDPGPAAATRVDWDPKSGFLQAV
                     FDAPATGPLVRIGYRGEVWLTFDETDRLLGIDLHNAPPALVALLPPAQQHRYFWHSTAR
                     GDGVAWWADHATGHAWITAAPGLAHHRATAVTDIEVGTRTDRPAVLRLHVQANP"
     gene            5470..6714
                     /gene="cofC"
     CDS             5470..6714
                     /codon_start=1
                     /gene="cofC"
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 71.1; E-value: 1.4e-21)"
                     /gene_kind="transport"
                     /product="major facilitator superfamily (MFS) transporter"
                     /protein_id="QTK22484.1"
                     /transl_table=11
                     /translation="MYTRVDPPKVMLMSFLILLRSPSVTRLLLGSWVGRLPSAMAALTI
                     PLALREAGSGYGFVGAAAGSYAIAAAVGSPLLGRLVDRWGQTRVLVPTALLAAAGFVAI
                     ALAPSQPAAVLVGAVLAGSMTPPLEPCLRVLWPAIAPEGKLESAYALDSSAQELVFVAG
                     PLVVTGSVAVWSPTAALYVQALLGLFGVAVVASSRPSRQWRAEARSTDWLGPLRSGRLV
                     TLLSALIGVGFAIGTLNVLVVSYAERWDVPGGAPSLLALNAFGSLAGVLVYGSRSWPGT
                     LANRGLLFAAGLVVGYGLLVLVPPPGYMVVLMLLTGAFLAPMLTVTFVLVGELAPPGTT
                     TEAFAWLVTLFAAGTSLGSAAVGNVLAHTNEHWAALCGTAGALVTLTILALGRKGFAAG
                     PVAAPVPATADAAQH"
     misc_feature    5521..5523
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 ggatcaggcg agcaactggt cgaccagatg ggccaccgcg tggtcgtcgt tgctcggcag
       61 gagccggtcg gcggcgcggc ggacggtgtc gggggcgttc gcgggggcgg cgccgagacc
      121 tgcgagcgtg agcatcccgc agtcgttgag gccgtcgccg acggcgaccg tctcggcggg
      181 gtgcaggccc aggtccgccg cgatccaggc gagtacgccg tgcttgccgg tgccgcgcgg
      241 gccgagttcg aggaagtgtc gtccggacgc ggtgacttcg gcgtcggaac ccaccaatcc
      301 ctggacggcg tccacgagtt cggcgccgaa cggtgcgaac ggacaggcca gcaccttcac
      361 caccggccgc gcgggctcga ccgcgccccg ccactcgacc ccgctccagt gacgcgccag
      421 ctcttccggg aagcccggct ggacgaccgt cccgtccagc aggtcgaagg ccagcgccca
      481 gtccggatgc gccttcccaa ggatggcggc gactcgatgg agcgccgccg cgtcgaagac
      541 gagctgccgg ctcggccgcc gttcgcccgg ccggaacacc aacgccccgt tcccgtgcgc
      601 ccagtaggcc gagggcggga tgcccgaccg gatctcggcc ggcacgtcgc gcggggggcg
      661 ggccgtgacc accgcgacgg cgagtccggc cgccaccgcc cggccgagcg cgtccgacac
      721 ggcgccgggc agcacgccgg acgagtcgag cagcgtcccg tccagatcgc aggcgagcag
      781 ccggtacccg tcagccatgg tcagccctcc gaggcttctt catggcttct cccagaaagc
      841 gcagggtcag ccgggccagc cccgcaccgg tcaccacggc ctcgacgtcg gccctgcccg
      901 cgtgccgccg ggccgtcggc ccggtgccga gcggcaccca gagccactgg gtgtcgacga
      961 ccgcgcatcc gatgacgtcg tcaccttcca cccgggggat ccggtcggag acctgaacag
     1021 ggatgtcgtg gacgtcgacc gaggtgaccg cgccggacgc accgagcccg acccacgcga
     1081 cggtccggaa cgacatcacg gccgcgcccg gcccgtccgc gtcgggcagc aggtcgacgg
     1141 agaactcccc acgcccctcg tcccattggg cctcgggcgt gcagatcccg gccgtgccgg
     1201 tgtgcgattc cacggttcca ctcctgtcgg tcgcagttcg tgcaccttca gacgtgctgg
     1261 aggcggtcga gcccgacgac aggtggggtg tccagcctgc ccggtcggag ttcgatctcc
     1321 ccgaggacgg tgtcgcgcgg cgtggaggcc gcccaggaca ccacttcggc aacggattcc
     1381 acgctcatct tgtaggcgga gtggtcgtcg tcgaagttcc ggatggctcc ggggctgagc
     1441 agggtggtcc gcaccccgtg gcggcgctcc tccatgagca ggacctccgc cacctgcttg
     1501 agcgcggcct tggtggcgca gtacgcgacg ccgccctcga acggccggga cccggcgtgc
     1561 gagcccatga gcacgatgtg cccctgcgca cggcgcagca gcggcaacgc ggcctggacg
     1621 aggcgcacgg gcgcggtgag gttgaccgcg acggcctcgt cccagtcctg cgcggtgacg
     1681 tccgcgaccg cgccgaagcc gcgggtgacg gcgttgacga cgagcaggtc gaggcgcggg
     1741 gcgtcggcga ggacctgctc ggcggcccgg gcgacggcgg cggggtcgcc gaagtcgacg
     1801 gtgacggggt cgtcgtggtc cgcgcagggg gagcggttga ggcagcggac ggtgtacccg
     1861 tcggcgatca gccggctgcg gacggcccgg ccggtgcccc ggttgctccc cgtcaccagg
     1921 gcgagcggtg gcgccgcagg ctcacccacc ggagaccatc gagatgagtt cggcccagcg
     1981 ggcgaggatg tcctcccggc cggcgccctg gcggaacatg tccttgtcgt agggccgtcc
     2041 gtcggcggac ttgaggcgca tgcagtccgg cgatatctcg gagttgacga ccagtccgtg
     2101 tttgtcgtcg ggcgcgatga cgaggcagaa gtcccagagg tcgagcggcg cgagcagctc
     2161 gcgcagcacc gcgttgcagt cgagcgcgac ctgccggtgg tgctcgacgt ccactccgag
     2221 cagccggagg tagtcctcgc cgatcggctg gtcctccggg tcgacccggt agtcgaactt
     2281 cacgaccggg cggtcgagga cctgcccctc ctcgaagagc ccggggtact tgcggatggt
     2341 cgagccggtg gcccggttct tgacgatgac ctcgaacggc ggggccggcc ggtagtccgc
     2401 gaggtaactg accggcccca cgcgttcgcg aaaaacggtg tacacaccgc gttcggcgag
     2461 tcgagccgaa acgtactcga agaagtcgag acgcaactcg gcagttccgt ccacgagttc
     2521 gtcgcgatcg taggtgaaac tccggagcga gggaatcatc tcgatcaggc agaggccttc
     2581 gtcgagatgc cagagccgtt tgctccgccc ctcgatgtcc ggagtacggg aagtcacgga
     2641 aaccgcatct aaggcagcca caggtcgctc tcaggaggtc gggcacaaag cagtgccagg
     2701 acttaaatga tcagcggtgc ggcaagtctg gcacgggcgt gaccggaaag aaagagcctt
     2761 cggcaggttt agaagtgatc atgacaggat cggggacggg atcagaagtg tgccgaagac
     2821 cctgccccgc gactcggtcg tgagcggact cagcgggcac cgaacaggcc cggaagcagt
     2881 cgtgcagaat gttcgtcatg ccagagcagc atcggattcg cgggcgtcgg gccgcggaga
     2941 tcgccgccga cgtcgagcag gccgtcgccg ccggacacct cgcccccggc agccccctgc
     3001 ccccgctccg ccggctcgcc accgagttgg gcgtcaaccc caacaccgcg gcggcggcct
     3061 accgtttgct gcgcgaccgc ggcgtcatcg agaccggcgg gcgacgcggc acccgggtgt
     3121 cgccccggcc gacgcacatc gcgcgcgccc acctgcactt cgaagtcccg gacggtgtcc
     3181 gcgatctgac ggacggcaac ccggatcccg gcctgcttcc gccgctcgcc gacgccctgg
     3241 cgttcgcggc gggcgagcag ctgcgcgacc cggtcctgta cggccgaccc gcggtggacc
     3301 ccggcctact ggcgatcgcc cggcgggagt tcgcagccga cggcctgccc ggcgagacca
     3361 ccgccgtcac ctcgggcgcc ctcgacgcga tcgagcgggt gttacagacc cggctgcgcc
     3421 cgggcgacct ggtcgccgtc gaggacccgg gctggggcag cctgcacgac ctgctcccgg
     3481 ctctcggcct gcggatgacc gggatcgggg tggacgacga agggcccctc ccgcaggacg
     3541 tcgcggtggc gctggcggcc ggcgccgccg ccctggtggt cacctcgcgc gcgcagaacc
     3601 ccaccggcgc gacggtcggc ccaggccgcg ccgccgagct gcgcgcggtg ctggcgaacc
     3661 gtccggacgt gctgctgatc gaggacgact tcggccacgc catcgcggac accccgtacc
     3721 acccggtgtg cgcggcgaac ggccgtccgg tcgtgcggca ctggacggtg gtccgatcgg
     3781 tcaccaaact cctcggcccc gacatgcggc tggccgtgct gaccggcgac cccgacaccg
     3841 tggaccgcct gcgcggccgc cagcggctgg gcaccggctg ggtcagccac gtgctccagc
     3901 gggcggcggc ccggctgctg gcggacgagt cggtggaccg cgcgcgggtg gccgcccact
     3961 acaccgagcg gcgcggcgcg ctgatccgcg cactggctgc ggagggcgtc ccggcccggg
     4021 gacgcagcgg cttcaacgtc tggatcccgg tgcacagcga gacctcggcc gtcgtggcgc
     4081 tgctgcagcg gggctgggcg gtggccccgg gtgcgccgtt ccggctgcgg tccgggcccg
     4141 ggctgcggct gaccgtctcg ggcctcgccc tggacgagct ccccgcgctg gccgccgacg
     4201 tggccgcagc actccgggtc gatccggaac gcgggcgcct gacgtgaacg ggcctggcct
     4261 gacgcgtgct tgacacggcg gatcggtgcg aacgatcctg acgggcggat ctggagagaa
     4321 gtcggccgtt ccgcctctcc accgacccgt gtccaacggc cgagcccgac cggatgcccg
     4381 tcaccacgcg ccggacgcgc ttgcgcaggt cgtttccacg cccccaccca gcacggaccg
     4441 aggagtccga aggccgtgac gtcgatattc gatcgcctgt acgaccacac cctcgccgac
     4501 ctgggcgcac tcgacgcgcc ctacgacacc ggccacctct cccggaccgc cgcgctggcg
     4561 ggccggatcg ccgaggagtc ggggctcgcc gcgggcaccg cccgctgcgc cgcccacctg
     4621 taccaccgct tccgcctgcc cggcgcgcgg gatgccccgg ccgggacccg ggacagcgcg
     4681 ctcgacttcc tgacccgttc gggggtgccc ggggaactgc accgggacct gctcacggtg
     4741 gtcggcccgg gttcaccggc cgccgagacc ccgtaccgtg cggccgtgct ggacgccgag
     4801 cggatcgatg cgatgggcgc ggccgggctc cagcgggcgc tgaccgggga ggggctgccc
     4861 tggcacccgg acggcccggc cgcgggccgt cctcggccgg ccccgccgga gctgtacgag
     4921 gaactggtcc gggccgagcg cgagctgctg accgagccgg cccgccgcct ggccgccgac
     4981 cggatggacc tggtgcaccg gctggccgcc gactaccgga cggaggccga gctgggccgt
     5041 ctcccgggcg agcccgatcc cggcccggcg gcggcgaccc gggtggactg ggacccgaag
     5101 tcgggtttcc tgcaagccgt gttcgacgcc ccggcgaccg gcccgctggt gcggatcggc
     5161 taccgcggcg aggtctggct gaccttcgac gaaacggacc gcctgctcgg catcgaccta
     5221 cacaacgcgc cgcccgccct cgtcgccctc ctcccgcccg cccagcagca ccgctacttc
     5281 tggcacagca cggcccgcgg cgacggcgtt gcgtggtggg cggaccacgc caccgggcac
     5341 gcctggatca ccgctgcgcc gggcctggcc caccaccgcg cgaccgccgt cacggacatc
     5401 gaggtgggga cccgtacgga ccgtccggcg gtccttcgtc ttcatgtaca ggccaatcca
     5461 tgaatcgacg tgtacacgcg cgtagatccc cctaaggtga tgctcatgag cttcctgatc
     5521 ttactccgct ccccttccgt cacccgtctg ttgctgggca gttgggtcgg gagactgccc
     5581 tccgccatgg ccgcgctcac catcccgctg gcgctgcgcg aggccgggtc cgggtacggc
     5641 ttcgtcggcg ccgcggccgg ctcgtacgcg atcgcggcgg cggtcggctc cccgctgctc
     5701 ggccggctgg tcgaccgctg ggggcagacc agggtcctgg tcccgaccgc gctgctcgcc
     5761 gcggcgggct tcgtcgccat cgcgctggcg ccgagccagc ccgccgccgt cctcgtcggc
     5821 gccgtgctcg cgggctcgat gacgcccccg ctggagccgt gcctgcgggt gctctggccc
     5881 gcgatcgccc ctgaggggaa gctcgaatcg gcgtacgcgc tcgactccag cgcgcaggaa
     5941 ctcgtcttcg tggccgggcc gttggtggtc accggcagcg tcgccgtctg gtcccccacg
     6001 gccgccctgt acgtccaggc gctgctcggc ctgttcgggg tcgcggtggt ggccagctcg
     6061 cggccgtccc ggcagtggcg ggccgaggcg cgctcgaccg actggctcgg gccgctgcgc
     6121 agcggacggc tggtcaccct gctcagcgcg ctgatcgggg tgggcttcgc gatcggcacc
     6181 ctgaacgtcc tggtggtctc gtacgcggag cgctgggacg tgcccggcgg cgcgccctcc
     6241 ctgctggccc tgaacgcctt cggctcgctc gccggtgtgc tggtctacgg ctcgcgcagc
     6301 tggccgggca cgctcgccaa ccgcgggctg ctgttcgcgg ccggcttggt ggtcgggtac
     6361 gggctgctgg tcctggtgcc gcctccgggc tacatggtcg tgctgatgct gctcaccggg
     6421 gcgttcctcg ctccgatgct gaccgtcacc ttcgtgctgg tgggcgagtt ggcgccgccg
     6481 gggaccacca cggaggcctt cgcctggctc gtgacgctgt tcgccgccgg cacctcgctg
     6541 ggctcggcgg ccgtcggcaa cgtgctggcg cacaccaacg agcactgggc ggccctgtgc
     6601 ggcaccgctg gcgccctcgt caccctgacg atcctggccc tcggccggaa gggcttcgcc
     6661 gcgggaccgg tcgcagcccc ggtcccggcc acggccgacg cggcccagca ctgaacg
//
