BGC0002462: coformycin biosynthetic gene cluster from Streptomyces kaniharaensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 344 - 7,060 nt. (total: 6,717 nt).
This entry is originally from NCBI GenBank MK830994.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002462
Short description coformycin biosynthetic gene cluster from Streptomyces kaniharaensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
MK830994.1
344 - 7060
via Heterologous expression, Enzymatic assays
Compounds
  • coformycin
Species Streptomyces kaniharaensis [taxonomy]
References
Chemical products information
coformycin Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QTK22478.1
 347 - 1141 (-) hypothetical protein
    copy AA seq
    copy Nt seq
    • QTK22479.1
    		 1134 - 1556 (-) hypothetical protein
      copy AA seq
      copy Nt seq
      • QTK22480.1
      • cofA
      		 1591 - 2292 (-) short-chain dehydrogenase
        copy AA seq
        copy Nt seq
        • QTK22481.1
        • cofB
        		 2285 - 2980 (-) SAICAR synthetase
          copy AA seq
          copy Nt seq
          • QTK22482.1
          		 3232 - 4590 (+) GntR family transcriptional regulator
            copy AA seq
            copy Nt seq
            • QTK22483.1
            		 4799 - 5806 (+) hypothetical protein
              copy AA seq
              copy Nt seq
              • QTK22484.1
              • cofC
              		 5813 - 7057 (+) major facilitator superfamily (MFS) transporter
                copy AA seq
                copy Nt seq
                Biosynthesis information
                Annotation changelog

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-10-07
                Added chemical structures for compounds: coformycin.
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-10-07
                Added NPAtlas links to compounds: coformycin.
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Entry added
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Similar known gene clusters from MIBiG 4.0
                Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                Click on reference genes to show details of similarities to genes within the current region.
                Click on an accession to open that entry in the MiBIG database.