BGC0002477 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002477 (Streptomyces sp. CB00072)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,498	High	thioangucycline A/thioangucycline B	PKS

BGC0002477 - Region 1 - T2PKS

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Location: 1 - 72,498 nt. (total: 72,498 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,499
Label		BGC0002477

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

AMK17_08300: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK17_08305: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AMK17_08315: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMK17_08340: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AMK17_08360: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase transferase

AMK17_08295: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

AMK17_08345: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Lyases: cyclase

AMK17_08310: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

AMK17_08335: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

AMK17_08325: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AMK17_08330: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002477.3	1.00	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000235.5	0.82	PKS	kiamycin	Streptomyces sp. W007
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000253.4	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0002047.2	0.59	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001596.3	0.57	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus
BGC0002504.2	0.56	PKS	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002477.3	1.00	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000235.5	0.82	PKS	kiamycin	Streptomyces sp. W007
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000253.4	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0002047.2	0.59	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001596.3	0.57	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus
BGC0002504.2	0.56	PKS	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72498
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 700.6; E-value: 1.2e-213)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 384 Da
acetyl-CoA_9: 426 Da

AMK17_08300: KR (Score: 134.6; E-value: 1.1e-41)
AMK17_08305: OXY (Score: 536.7; E-value: 1.2e-163)
AMK17_08310: CYC C7-C12 (Score: 497.7; E-value: 2.4e-152)
AMK17_08315: KR C9 (Score: 474.3; E-value: 2.2e-145)
AMK17_08320: ACP (Score: 132.4; E-value: 1.1e-41)
AMK17_08325: CLF 8|9 (Score: 700.6; E-value: 1.2e-213)
AMK17_08330: KS (Score: 771.6; E-value: 4e-235)
AMK17_08335: CYC C4-C17/C2-C19 (Score: 192.8; E-value: 1.3e-59)
AMK17_08340: OXY (Score: 564.1; E-value: 6.2e-172)
AMK17_08345: MET C2O|C2N (Score: 308.1; E-value: 1.6e-94)
AMK17_08360: KR (Score: 100.5; E-value: 2.9e-31)