BGC0002477: thioangucycline A biosynthetic gene cluster from Streptomyces sp. CB00072
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Location: 1,870,363 - 1,894,318 nt. (total: 23,956 nt).
This entry is originally from NCBI GenBank LIPB01000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002477
Short description thioangucycline A biosynthetic gene cluster from Streptomyces sp. CB00072
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LIPB01000001.1
1870363 - 1894318
via Heterologous expression, Knock-out studies
Compounds
  • thioangucycline A
  • thioangucycline B
Species Streptomyces sp. CB00072 [taxonomy]
References
Chemical products information
thioangucycline A Evidence:
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Chemical database entries
NPAtlas
thioangucycline B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMK17_08255
  • OKI59850.1
 1870363 - 1871037 (+) transcriptional regulator
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    • AMK17_08260
    • OKI59851.1
    		 1871099 - 1872019 (-) thioesterase
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      • AMK17_08265
      • OKI60412.1
      		 1872063 - 1872854 (-) oxidoreductase
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        • AMK17_08275
        • OKI59852.1
        		 1875100 - 1875783 (-) hypothetical protein
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          • AMK17_08280
          • OKI59853.1
          		 1875928 - 1876611 (-) hypothetical protein
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            • AMK17_08285
            • OKI59854.1
            		 1876640 - 1877869 (-) arabinose transporter permease
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              • AMK17_08290
              • OKI59855.1
              		 1877981 - 1878223 (-) hypothetical protein
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                • AMK17_08295
                • OKI60413.1
                		 1878220 - 1879752 (-) methylmalonyl-CoA carboxyltransferase
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                  • AMK17_08300
                  • OKI59856.1
                  		 1879803 - 1880567 (-) dehydrogenase
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                    • AMK17_08305
                    • OKI59857.1
                    		 1880605 - 1882575 (-) monooxygenase
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                      • AMK17_08310
                      • OKI59858.1
                      		 1882579 - 1883523 (-) cyclase
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                        • AMK17_08315
                        • OKI59859.1
                        		 1883586 - 1884371 (-) ketoacyl reductase
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                          • AMK17_08320
                          • OKI59860.1
                          		 1884407 - 1884676 (-) actinorhodin polyketide synthase
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                            • AMK17_08325
                            • OKI59861.1
                            		 1884734 - 1885954 (-) beta-ketoacyl synthase
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                              • AMK17_08330
                              • OKI59862.1
                              		 1885951 - 1887231 (-) beta-ACP synthase
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                                • AMK17_08335
                                • OKI59863.1
                                		 1887228 - 1887554 (-) polyketide synthase
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                                  • AMK17_08340
                                  • OKI59864.1
                                  		 1887595 - 1889097 (-) monooxygenase
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                                    • AMK17_08345
                                    • OKI59865.1
                                    		 1889178 - 1890161 (-) methyltransferase
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                                      • AMK17_08350
                                      • OKI59866.1
                                      		 1890504 - 1891970 (-) EmrB/QacA family drug resistance transporter
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                                        • AMK17_08355
                                        • OKI59867.1
                                        		 1892093 - 1892788 (+) TetR family transcriptional regulator
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                                          • AMK17_08360
                                          • OKI59868.1
                                          		 1892905 - 1893612 (+) short-chain dehydrogenase
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                                            Biosynthesis information
                                            Annotation changelog

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Added chemical structures for compounds: thioangucycline A, thioangucycline B.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-10-07
                                            Added NPAtlas links to compounds: thioangucycline A, thioangucycline B.
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Entry added
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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