BGC0002478: rubiginone A2 biosynthetic gene cluster from Streptomyces sp. CB02414
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 189,575 - 230,252 nt. (total: 40,678 nt).
This entry is originally from NCBI GenBank LIPF01000008.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002478
Short description rubiginone A2 biosynthetic gene cluster from Streptomyces sp. CB02414
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: LIPF01000008.1
Compounds
  • rubiginone A2
  • rubiginone J
  • rubiginone K
  • rubiginone L
  • rubiginone M
  • rubiginone N
  • ochromycinone
  • rubiginone B2
Species Streptomyces sp. CB02414 [taxonomy]
References
Chemical products information
rubiginone A2
Copy SMILES
Chemical database entries
NPAtlas
rubiginone J
Copy SMILES
Chemical database entries
NPAtlas
rubiginone K
Copy SMILES
Chemical database entries
NPAtlas
rubiginone L
Copy SMILES
Chemical database entries
NPAtlas
rubiginone M
Copy SMILES
Chemical database entries
NPAtlas
rubiginone N
Copy SMILES
Chemical database entries
NPAtlas
ochromycinone
Copy SMILES
Chemical database entries
NPAtlas
rubiginone B2
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMK11_25540
  • OKI81334.1
 189575 - 190288 (-) transcriptional regulator
copy AA seq
copy Nt seq
  • AMK11_25545
  • OKI81335.1
 190847 - 191554 (-) short-chain dehydrogenase
copy AA seq
copy Nt seq
  • AMK11_25550
  • OKI81336.1
 191659 - 192498 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25555
  • OKI81337.1
 192728 - 194197 (+) monooxygenase
copy AA seq
copy Nt seq
  • AMK11_25560
  • OKI81338.1
 194250 - 194576 (+) polyketide synthase
copy AA seq
copy Nt seq
  • AMK11_25565
  • OKI81339.1
 194573 - 195847 (+) beta-ACP synthase
copy AA seq
copy Nt seq
  • AMK11_25570
  • OKI81340.1
 195844 - 197064 (+) beta-ketoacyl synthase
copy AA seq
copy Nt seq
  • AMK11_25575
  • OKI81341.1
 197126 - 197383 (+) actinorhodin polyketide synthase
copy AA seq
copy Nt seq
  • AMK11_25580
  • OKI81342.1
 197418 - 198203 (+) ketoacyl reductase
copy AA seq
copy Nt seq
  • AMK11_25585
  • OKI81343.1
 198231 - 199181 (+) cyclase
copy AA seq
copy Nt seq
  • AMK11_25590
  • OKI81344.1
 199185 - 201221 (+) monooxygenase
copy AA seq
copy Nt seq
  • AMK11_25595
  • OKI81345.1
 201218 - 201988 (+) dehydrogenase
copy AA seq
copy Nt seq
  • AMK11_25600
  • OKI81346.1
 202049 - 203617 (+) methylmalonyl-CoA carboxyltransferase
copy AA seq
copy Nt seq
  • AMK11_25605
  • OKI81347.1
 203651 - 203866 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25610
  • OKI81348.1
 203924 - 204892 (+) monooxygenase
copy AA seq
copy Nt seq
  • AMK11_25615
  • OKI81349.1
 204889 - 206133 (+) arabinose transporter permease
copy AA seq
copy Nt seq
  • AMK11_25620
  • OKI81538.1
 206139 - 206750 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25625
  • OKI81350.1
 206763 - 207428 (+) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25630
  • OKI81539.1
 207523 - 208164 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25635
  • OKI81351.1
 208888 - 209493 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25640
  • OKI81352.1
 209618 - 210445 (+) oxidoreductase
copy AA seq
copy Nt seq
  • AMK11_25645
  • OKI81353.1
 210551 - 211765 (+) cytochrome
copy AA seq
copy Nt seq
  • AMK11_25650
  • OKI81354.1
 211748 - 212614 (-) methyltransferase
copy AA seq
copy Nt seq
  • AMK11_25655
  • OKI81355.1
 212608 - 213390 (-) multidrug transporter
copy AA seq
copy Nt seq
  • AMK11_25660
  • OKI81356.1
 213387 - 214025 (-) LysR family transcriptional regulator
copy AA seq
copy Nt seq
  • AMK11_25665
  • OKI81357.1
 214022 - 214783 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25670
  • OKI81358.1
 214780 - 215901 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25675
  • OKI81359.1
 215904 - 217370 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25680
  • OKI81360.1
 217367 - 218242 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25685
  • OKI81361.1
 218235 - 219938 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25690
  • OKI81540.1
 219935 - 220564 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25695
  • OKI81362.1
 220570 - 221865 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AMK11_25700
  • OKI81363.1
 221869 - 222075 (-) ferredoxin
copy AA seq
copy Nt seq
  • AMK11_25705
  • OKI81364.1
 222081 - 223292 (-) cytochrome
copy AA seq
copy Nt seq
  • AMK11_25710
  • OKI81365.1
 223503 - 224180 (-) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • AMK11_25715
  • OKI81366.1
 224320 - 225801 (+) EmrB/QacA family drug resistance transporter
copy AA seq
copy Nt seq
  • AMK11_25720
  • OKI81367.1
 226192 - 227178 (+) methyltransferase
copy AA seq
copy Nt seq
  • AMK11_25725
  • OKI81368.1
 227213 - 228970 (+) acetyl-CoA carboxylase
copy AA seq
copy Nt seq
  • AMK11_25730
  • OKI81369.1
 229029 - 230252 (+) S-adenosylmethionine synthetase
copy AA seq
copy Nt seq
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Entry added
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added chemical structures for compounds: rubiginone N, rubiginone M, rubiginone K, rubiginone L, rubiginone A2, ochromycinone, rubiginone J.
  • Added NPAtlas links to compounds: rubiginone N, rubiginone M, rubiginone K, rubiginone L, rubiginone A2, ochromycinone, rubiginone J.
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.