BGC0002498 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002498 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	200,565	High	desulfoclethramycin/clethramycin	other:other

BGC0002498 - Region 1 - T1PKS

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Location: 1 - 200,565 nt. (total: 200,565 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 200,566
Label		BGC0002498

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase

cle1: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

cle10: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

cle29: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

cle9: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: acetyltransferase acylase kinase

cle33: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

cle6: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

cleB: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

cleG: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: dehalogenase esterase

cle15: thioesterase

smcogs: SMCOG1004: thioesterase

cle31: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

cle36: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

cle37: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

cleA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cleC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cleD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cleE: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cleF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cleH: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cleI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cleJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002498.3	0.98	other (other)	desulfoclethramycin, clethramycin	Streptomyces sp.
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002355.2	0.74	PKS, other (other)	tetrafibricin	Streptomyces neyagawaensis
BGC0002357.3	0.73	PKS, other (other)	neomediomycin B	Streptomyces sp. RK95-74
BGC0000018.5	0.70	PKS	angolamycin	Streptomyces eurythermus
BGC0002356.3	0.70	PKS, other (other)	mediomycin A	Streptomyces blastmyceticus
BGC0001662.4	0.70	PKS	mediomycin A	Kitasatospora mediocidica
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002498.3	1.00	other (other)	desulfoclethramycin, clethramycin	Streptomyces sp.
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002355.2	0.74	PKS, other (other)	tetrafibricin	Streptomyces neyagawaensis
BGC0002357.3	0.74	PKS, other (other)	neomediomycin B	Streptomyces sp. RK95-74
BGC0002356.3	0.70	PKS, other (other)	mediomycin A	Streptomyces blastmyceticus
BGC0001662.4	0.70	PKS	mediomycin A	Kitasatospora mediocidica
BGC0000018.5	0.70	PKS	angolamycin	Streptomyces eurythermus
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 8896 - 191577:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ohmal - ccmal - ohmal - ohmal) + (ccmal - ohmal) + (ccmal - ohmal - ccmal - ohmal - ccmal) + (Me-ohmal) + (ohmal - ccmal - ccmal) + (ccmal - ccmal - ccmal - ccmal) + (Me-ohmal - Me-ohmal) + (ccmal - redmal - ccmal) + (Me-ccmal)
Non-colinear ordering:: cleA + cleB + cleC + cleD + cleE + cleF + cleG + cleH + cleJ

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cleA: mal - mal - mal - mal - mal

PKS_AT (684..982): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 229.9
inactive: 123.4
Methoxymalonyl-CoA: 77.5
Methylmalonyl-CoA: 75.1
Isobutyryl-CoA: 48.9
Propionyl-CoA: 39.2
Acetyl-CoA: 35.2
Ethylmalonyl-CoA: 27.1
2-Methylbutyryl-CoA: 23.2
Benzoyl-CoA: 20.1
CHC-CoA: 14.7
trans-1,2-CPDA: 10.2
fatty_acid: 8.3
3-Methylbutyryl-CoA: 5.9

PKS_AT (2234..2525): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 238.6
inactive: 128.0
Methylmalonyl-CoA: 66.1
Methoxymalonyl-CoA: 65.7
Propionyl-CoA: 42.5
Isobutyryl-CoA: 28.4
Acetyl-CoA: 23.1
trans-1,2-CPDA: 22.1
Benzoyl-CoA: 21.5
2-Methylbutyryl-CoA: 21.5
Ethylmalonyl-CoA: 20.7
CHC-CoA: 11.3
fatty_acid: 8.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (3762..4053): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 236.4
inactive: 121.5
Methoxymalonyl-CoA: 67.6
Methylmalonyl-CoA: 66.3
Propionyl-CoA: 42.9
Benzoyl-CoA: 25.7
Acetyl-CoA: 24.2
Isobutyryl-CoA: 24.1
Ethylmalonyl-CoA: 23.3
2-Methylbutyryl-CoA: 18.7
CHC-CoA: 17.8
trans-1,2-CPDA: 16.5
fatty_acid: 9.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (5583..5874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.6
inactive: 128.0
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 71.5
Propionyl-CoA: 47.6
Isobutyryl-CoA: 34.0
Ethylmalonyl-CoA: 33.8
2-Methylbutyryl-CoA: 29.5
Benzoyl-CoA: 25.7
Acetyl-CoA: 24.8
trans-1,2-CPDA: 19.1
CHC-CoA: 17.2
fatty_acid: 9.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (7125..7420): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.6
inactive: 120.3
Methoxymalonyl-CoA: 76.0
Methylmalonyl-CoA: 75.0
Isobutyryl-CoA: 51.4
Propionyl-CoA: 41.1
Ethylmalonyl-CoA: 32.6
Acetyl-CoA: 24.7
Benzoyl-CoA: 23.5
2-Methylbutyryl-CoA: 18.8
3-Methylbutyryl-CoA: 16.3
trans-1,2-CPDA: 13.7
CHC-CoA: 12.6
fatty_acid: 9.3

cleB: mal - mal

PKS_AT (576..867): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 233.6
inactive: 115.5
Methoxymalonyl-CoA: 66.6
Methylmalonyl-CoA: 65.8
Propionyl-CoA: 43.1
Isobutyryl-CoA: 37.0
Acetyl-CoA: 24.9
Benzoyl-CoA: 24.5
2-Methylbutyryl-CoA: 19.3
trans-1,2-CPDA: 16.0
CHC-CoA: 14.5
fatty_acid: 10.9
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -3.9

PKS_AT (2366..2658): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.0
inactive: 124.6
Methoxymalonyl-CoA: 71.0
Methylmalonyl-CoA: 70.9
Propionyl-CoA: 45.5
Ethylmalonyl-CoA: 27.1
Isobutyryl-CoA: 26.2
Benzoyl-CoA: 24.9
Acetyl-CoA: 24.6
2-Methylbutyryl-CoA: 23.4
CHC-CoA: 17.4
trans-1,2-CPDA: 17.3
fatty_acid: 10.6
3-Methylbutyryl-CoA: 0.0

cleC: mal - mal - mal - mal - mal

PKS_AT (567..858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 236.1
inactive: 124.2
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 67.7
Propionyl-CoA: 43.3
Ethylmalonyl-CoA: 29.6
Benzoyl-CoA: 27.5
Isobutyryl-CoA: 26.9
Acetyl-CoA: 24.9
2-Methylbutyryl-CoA: 19.1
trans-1,2-CPDA: 18.5
CHC-CoA: 16.1
fatty_acid: 9.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2405..2696): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 241.2
inactive: 123.2
Methoxymalonyl-CoA: 72.4
Methylmalonyl-CoA: 71.8
Propionyl-CoA: 48.5
Ethylmalonyl-CoA: 31.9
2-Methylbutyryl-CoA: 30.2
Isobutyryl-CoA: 29.1
Acetyl-CoA: 26.9
Benzoyl-CoA: 20.8
CHC-CoA: 16.7
trans-1,2-CPDA: 16.6
fatty_acid: 9.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (3884..4177): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 236.7
inactive: 114.8
Methoxymalonyl-CoA: 70.6
Methylmalonyl-CoA: 66.3
Propionyl-CoA: 46.3
Isobutyryl-CoA: 34.8
Ethylmalonyl-CoA: 30.5
Benzoyl-CoA: 26.8
2-Methylbutyryl-CoA: 25.1
Acetyl-CoA: 23.1
trans-1,2-CPDA: 19.4
CHC-CoA: 14.9
fatty_acid: 12.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (5713..6004): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 239.2
inactive: 118.5
Methoxymalonyl-CoA: 69.6
Methylmalonyl-CoA: 66.4
Propionyl-CoA: 46.8
Isobutyryl-CoA: 33.0
Benzoyl-CoA: 27.4
Acetyl-CoA: 27.3
2-Methylbutyryl-CoA: 24.4
Ethylmalonyl-CoA: 20.4
trans-1,2-CPDA: 17.4
CHC-CoA: 14.7
fatty_acid: 14.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (7265..7557): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 237.7
inactive: 121.0
Methoxymalonyl-CoA: 69.5
Methylmalonyl-CoA: 68.0
Propionyl-CoA: 43.6
Isobutyryl-CoA: 25.9
Ethylmalonyl-CoA: 25.2
Benzoyl-CoA: 24.9
Acetyl-CoA: 24.6
2-Methylbutyryl-CoA: 20.5
trans-1,2-CPDA: 17.5
CHC-CoA: 15.9
fatty_acid: 10.2
3-Methylbutyryl-CoA: 0.0

cleD: mmal

PKS_AT (567..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 225.0
Ethylmalonyl-CoA: 221.1
Methoxymalonyl-CoA: 177.8
2-Methylbutyryl-CoA: 140.9
trans-1,2-CPDA: 127.4
CHC-CoA: 101.7
Propionyl-CoA: 100.8
Malonyl-CoA: 96.7
Isobutyryl-CoA: 83.7
Benzoyl-CoA: 68.9
3-Methylbutyryl-CoA: 57.8
Acetyl-CoA: 40.5
fatty_acid: 36.2
inactive: 30.3

cleE: mal - mal - mal

PKS_AT (572..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 244.6
inactive: 118.3
Methoxymalonyl-CoA: 70.4
Methylmalonyl-CoA: 61.1
Propionyl-CoA: 36.2
Isobutyryl-CoA: 29.2
Benzoyl-CoA: 21.1
2-Methylbutyryl-CoA: 20.6
Ethylmalonyl-CoA: 20.3
Acetyl-CoA: 17.5
CHC-CoA: 10.4
trans-1,2-CPDA: 7.1
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2134..2426): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 236.7
inactive: 111.2
Methoxymalonyl-CoA: 68.7
Methylmalonyl-CoA: 61.9
Propionyl-CoA: 40.6
Isobutyryl-CoA: 28.2
Benzoyl-CoA: 24.9
Acetyl-CoA: 22.3
Ethylmalonyl-CoA: 18.0
trans-1,2-CPDA: 16.5
CHC-CoA: 12.1
fatty_acid: 12.0
2-Methylbutyryl-CoA: 11.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3890..4190): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.0
inactive: 109.0
Methoxymalonyl-CoA: 65.5
Methylmalonyl-CoA: 62.3
Propionyl-CoA: 40.5
Isobutyryl-CoA: 29.5
Ethylmalonyl-CoA: 23.7
2-Methylbutyryl-CoA: 23.7
Acetyl-CoA: 21.0
Benzoyl-CoA: 18.8
trans-1,2-CPDA: 16.0
CHC-CoA: 12.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

cleF: mal - mal - mal - mal

PKS_AT (575..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 242.0
inactive: 127.2
Methoxymalonyl-CoA: 74.7
Methylmalonyl-CoA: 70.5
Propionyl-CoA: 45.0
Isobutyryl-CoA: 43.9
Benzoyl-CoA: 33.5
Ethylmalonyl-CoA: 31.5
Acetyl-CoA: 25.2
2-Methylbutyryl-CoA: 24.9
trans-1,2-CPDA: 20.9
CHC-CoA: 19.6
fatty_acid: 14.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (2377..2666): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 244.4
inactive: 119.2
Methoxymalonyl-CoA: 73.0
Methylmalonyl-CoA: 70.9
Propionyl-CoA: 48.9
Isobutyryl-CoA: 35.9
Ethylmalonyl-CoA: 33.4
Benzoyl-CoA: 26.8
2-Methylbutyryl-CoA: 26.6
Acetyl-CoA: 23.1
trans-1,2-CPDA: 18.9
CHC-CoA: 16.5
fatty_acid: 13.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4197..4488): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 239.0
inactive: 121.5
Methoxymalonyl-CoA: 72.0
Methylmalonyl-CoA: 66.2
Propionyl-CoA: 45.5
Isobutyryl-CoA: 32.1
Ethylmalonyl-CoA: 23.7
Benzoyl-CoA: 23.6
Acetyl-CoA: 20.2
2-Methylbutyryl-CoA: 20.1
trans-1,2-CPDA: 12.2
CHC-CoA: 12.2
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6011..6300): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 234.5
inactive: 117.8
Methoxymalonyl-CoA: 69.4
Methylmalonyl-CoA: 66.7
Propionyl-CoA: 45.0
Isobutyryl-CoA: 33.2
Ethylmalonyl-CoA: 29.8
Acetyl-CoA: 27.4
Benzoyl-CoA: 26.6
2-Methylbutyryl-CoA: 23.6
trans-1,2-CPDA: 20.1
CHC-CoA: 13.5
fatty_acid: 9.8
3-Methylbutyryl-CoA: 0.0

cleG: mmal - mmal

PKS_AT (570..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 226.8
Ethylmalonyl-CoA: 224.0
Methoxymalonyl-CoA: 178.7
2-Methylbutyryl-CoA: 142.1
trans-1,2-CPDA: 131.6
Propionyl-CoA: 104.6
CHC-CoA: 101.0
Malonyl-CoA: 100.7
Isobutyryl-CoA: 79.7
Benzoyl-CoA: 66.9
3-Methylbutyryl-CoA: 52.8
Acetyl-CoA: 41.2
fatty_acid: 41.0
inactive: 27.7

PKS_AT (2117..2416): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 223.2
Ethylmalonyl-CoA: 213.2
Methoxymalonyl-CoA: 176.4
2-Methylbutyryl-CoA: 147.1
trans-1,2-CPDA: 126.9
Propionyl-CoA: 101.3
Malonyl-CoA: 99.0
CHC-CoA: 96.2
Isobutyryl-CoA: 90.8
Benzoyl-CoA: 70.9
3-Methylbutyryl-CoA: 63.2
Acetyl-CoA: 49.3
fatty_acid: 39.7
inactive: 33.6

cleH: mal - mal - mal

PKS_AT (584..874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 235.8
inactive: 125.5
Methoxymalonyl-CoA: 77.2
Methylmalonyl-CoA: 67.0
Isobutyryl-CoA: 43.6
Propionyl-CoA: 39.0
Ethylmalonyl-CoA: 33.9
Benzoyl-CoA: 29.7
2-Methylbutyryl-CoA: 24.8
Acetyl-CoA: 22.8
CHC-CoA: 18.6
trans-1,2-CPDA: 15.2
fatty_acid: 13.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2344..2639): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 241.3
inactive: 132.6
Methylmalonyl-CoA: 67.1
Methoxymalonyl-CoA: 67.1
Propionyl-CoA: 43.8
Isobutyryl-CoA: 38.8
Acetyl-CoA: 26.8
Benzoyl-CoA: 25.3
2-Methylbutyryl-CoA: 22.0
trans-1,2-CPDA: 14.7
CHC-CoA: 14.1
fatty_acid: 11.6
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -2.7

PKS_AT (4426..4714): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 235.3
inactive: 125.4
Methoxymalonyl-CoA: 73.6
Methylmalonyl-CoA: 70.6
Propionyl-CoA: 42.7
Ethylmalonyl-CoA: 34.9
Benzoyl-CoA: 27.9
Acetyl-CoA: 27.5
Isobutyryl-CoA: 25.6
2-Methylbutyryl-CoA: 24.6
CHC-CoA: 18.8
trans-1,2-CPDA: 16.7
fatty_acid: 13.1
3-Methylbutyryl-CoA: 0.0

cleI: mal

PKS_AT (565..858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 230.6
inactive: 117.9
Methoxymalonyl-CoA: 69.2
Methylmalonyl-CoA: 64.0
Propionyl-CoA: 39.9
Ethylmalonyl-CoA: 27.5
Isobutyryl-CoA: 26.8
Acetyl-CoA: 25.4
trans-1,2-CPDA: 22.5
Benzoyl-CoA: 21.8
2-Methylbutyryl-CoA: 19.3
CHC-CoA: 16.8
fatty_acid: 11.1
3-Methylbutyryl-CoA: 0.0

cleJ: mmal

PKS_AT (445..744): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.6
Ethylmalonyl-CoA: 214.1
Methoxymalonyl-CoA: 173.4
2-Methylbutyryl-CoA: 142.3
trans-1,2-CPDA: 133.8
Propionyl-CoA: 101.5
CHC-CoA: 98.5
Malonyl-CoA: 96.3
Isobutyryl-CoA: 85.5
Benzoyl-CoA: 68.9
3-Methylbutyryl-CoA: 57.6
Acetyl-CoA: 46.4
fatty_acid: 38.8
inactive: 31.3

cle33: pk

PKS_AT (11..274): pk

ATSignature: (unknown)

No matches above 50%

minowa: CHC-CoA

Prediction, score:

CHC-CoA: 12.8
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

cle37: X

AMP-binding (96..458): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: QYSDCGSAFK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor