BGC0002498: desulfoclethramycin biosynthetic gene cluster from Streptomyces sp.
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Location: 1 - 200,565 nt. (total: 200,565 nt).
This entry is originally from NCBI GenBank MT994315.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002498
Short description desulfoclethramycin biosynthetic gene cluster from Streptomyces sp.
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
MT994315.1
1 - 200565
via Knock-out studies
Compounds
  • desulfoclethramycin
  • clethramycin
Species Streptomyces sp. [taxonomy]
References
Chemical products information
desulfoclethramycin Evidence:
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Chemical database entries
NPAtlas
clethramycin Evidence:
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Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QQZ01561.1
  • cle1
 2655 - 3674 (-) Gfo/Idh/MocA family oxidoreductase
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    • QQZ01562.1
    • cle2
    		 3767 - 4687 (-) TIM barrel protein
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      • QQZ01563.1
      • cle3
      		 4798 - 5676 (-) ABC transporter ATP-binding protein
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        • QQZ01564.1
        • cle4
        		 5682 - 6752 (-) ABC transporter permease
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          • QQZ01565.1
          • cle5
          		 6760 - 7770 (-) periplasmic binding protein/LacI transcriptional
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            • QQZ01566.1
            • cle6
            		 8054 - 9001 (+) PfkB domain protein
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              • QQZ01567.1
              • cle7
              		 9014 - 10147 (+) deoxyribose-phosphate aldolase superfamily protein
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                • QQZ01568.1
                • cle8
                		 10190 - 11122 (+) myo-inositol catabolism IolB domain protein
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                  • QQZ01569.1
                  • cle9
                  		 11119 - 13005 (+) thiamine pyrophosphate protein central region
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                    • QQZ01570.1
                    • cle10
                    		 13033 - 14529 (+) methylmalonate-semialdehyde dehydrogenase
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                      • QQZ01571.1
                      • cle11
                      		 14703 - 15209 (-) hypothetical protein
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                        • QQZ01572.1
                        • cle12
                        		 15376 - 17196 (-) hypothetical protein
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                          • QQZ01573.1
                          • cle13
                          		 17205 - 17636 (-) hypothetical protein
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                            • QQZ01574.1
                            • cle14
                            		 17890 - 20004 (+) integral membrane protein
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                              • QQZ01575.1
                              • cle15
                              		 20053 - 20907 (+) thioesterase
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                                • QQZ01576.1
                                • cle16
                                		 21008 - 23821 (+) LAL transcriptional regulator
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                                  • QQZ01577.1
                                  • cle17
                                  		 23874 - 24533 (-) two component transcriptional regulator, LuxR
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                                    • QQZ01578.1
                                    • cle18
                                    		 24526 - 25770 (-) integral membrane sensor signal transduction
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                                      • QQZ01579.1
                                      • cle19
                                      		 25878 - 26504 (+) integral membrane protein
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                                        • QQZ01580.1
                                        • cle20
                                        		 26744 - 28624 (+) membrane-flanked domain protein
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                                          • QQZ01581.1
                                          • cleA
                                          		 28897 - 53544 (+) PKS
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                                            • QQZ01582.1
                                            • cleB
                                            		 53592 - 63965 (+) PKS
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                                              • QQZ01583.1
                                              • cleC
                                              		 63991 - 89763 (+) PKS
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                                                • QQZ01584.1
                                                • cleD
                                                		 89830 - 94824 (+) PKS
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                                                  • QQZ01585.1
                                                  • cleE
                                                  		 95089 - 110727 (+) PKS
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                                                    • QQZ01586.1
                                                    • cleF
                                                    		 110779 - 132780 (+) PKS
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                                                      • QQZ01587.1
                                                      • cleG
                                                      		 132846 - 142466 (+) PKS
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                                                        • QQZ01588.1
                                                        • cleH
                                                        		 142496 - 159757 (+) PKS
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                                                          • QQZ01589.1
                                                          • cleI
                                                          		 159898 - 165639 (+) PKS
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                                                            • QQZ01590.1
                                                            • cleJ
                                                            		 165650 - 171577 (+) PKS
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                                                              • QQZ01591.1
                                                              • cle21
                                                              		 171914 - 172852 (+) radical SAM domain protein
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                                                                • QQZ01592.1
                                                                • cle22
                                                                		 172755 - 173606 (+) ABC transporter
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                                                                  • QQZ01593.1
                                                                  • cle23
                                                                  		 173603 - 174454 (+) aminoglycoside phosphotransferase
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                                                                    • QQZ01594.1
                                                                    • cle24
                                                                    		 174819 - 175034 (-) hypothetical protein
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                                                                      • QQZ01595.1
                                                                      • cle25
                                                                      		 175034 - 175468 (-) hypothetical protein
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                                                                        • QQZ01596.1
                                                                        • cle26
                                                                        		 175524 - 176378 (+) transcriptional regulator, XRE family
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                                                                          • QQZ01597.1
                                                                          • cle27
                                                                          		 176375 - 176584 (+) hypothetical protein
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                                                                            • QQZ01598.1
                                                                            • cle28
                                                                            		 176711 - 177553 (+) glycosyl transferase
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                                                                              • QQZ01599.1
                                                                              • cle29
                                                                              		 177651 - 178397 (-) short-chain dehydrogenase/reductase SDR
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                                                                                • QQZ01600.1
                                                                                • cle30
                                                                                		 178463 - 179101 (+) tetR family transcriptional regulator
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                                                                                  • QQZ01601.1
                                                                                  • cle31
                                                                                  		 179152 - 180066 (-) alpha/beta hydrolase fold protein
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                                                                                    • QQZ01602.1
                                                                                    • cle32
                                                                                    		 180249 - 180917 (+) transcriptional regulatory protein
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                                                                                      • QQZ01603.1
                                                                                      • cle33
                                                                                      		 181100 - 182038 (-) hypothetical protein
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                                                                                        • QQZ01604.1
                                                                                        • cle34
                                                                                        		 182072 - 183490 (-) ABC transporter
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                                                                                          • QQZ01605.1
                                                                                          • cle35
                                                                                          		 183487 - 184512 (-) ABC transporter
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                                                                                            • QQZ01606.1
                                                                                            • cle36
                                                                                            		 184727 - 185494 (+) thioesterase
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                                                                                              • QQZ01607.1
                                                                                              • cle37
                                                                                              		 185286 - 186959 (+) AMP-dependent synthetase and ligase
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                                                                                                • QQZ01608.1
                                                                                                • cle38
                                                                                                		 187020 - 188678 (-) tryptophan 2-monooxygenase
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                                                                                                  • QQZ01609.1
                                                                                                  • cle39
                                                                                                  		 188720 - 191530 (-) LAL transcriptional regulator
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                                                                                                    Biosynthesis information
                                                                                                    Annotation changelog

                                                                                                    Entry version: 2

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2022-10-07
                                                                                                    Added chemical structures for compounds: desulfoclethramycin.
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    2022-10-07
                                                                                                    Added NPAtlas links to compounds: desulfoclethramycin.
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 1

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2022-09-15
                                                                                                    Entry added
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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