BGC0002501 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002501 (Penicillium steckii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	53,110	High	penigainamide A/penigainamide B/penigainamide C/adametizine A/FA2097/outovirin A/outovirin C/pretrichodermamide C	other:other

BGC0002501 - Region 1 - NRPS

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Location: 1 - 53,110 nt. (total: 53,110 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 53,111
Label		BGC0002501

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase reductase

Pen10: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Pen12: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Pen14: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Pen15: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Pen16: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

PenC: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

PenF: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

PenT: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

PenT_: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: aminotransferase methyltransferase sulfotransferase

Pen4-1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Pen9: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

PenG: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

PenI: aminotransferase

smcogs: SMCOG1019: aminotransferase

PenK: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

PenM: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: ligase

PenP: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002501.3	0.91	other (other)	penigainamide A, penigainamide B, penigainamide C, adametizine A, FA2097, outovirin A, outovirin C, pretrichodermamide C	Penicillium steckii
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001249.5	0.62	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002075.3	0.61	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.61	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002501.3	0.99	other (other)	penigainamide A, penigainamide B, penigainamide C, adametizine A, FA2097, outovirin A, outovirin C, pretrichodermamide C	Penicillium steckii
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001249.5	0.62	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002075.3	0.61	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.61	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 38666:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PenP: Phe

Search NORINE for peptide: strict or relaxed

AMP-binding (584..968): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGHIYVMGGK
Nearest Stachelhaus code(s):: Phe DGHIYVMCGK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor