LOCUS       BGC0002504             26000 bp    DNA     linear   BCT 26-OCT-2020
DEFINITION  Nocardiopsis sp. nocardiopsistin biosynthetic gene cluster, complete
            sequence.
ACCESSION   BGC0002504
VERSION     BGC0002504
KEYWORDS    .
SOURCE      Nocardiopsis sp
  ORGANISM  Nocardiopsis sp.
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Nocardiopsis.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:52:07
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 26000
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..591
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QOP59266.1"
                     /transl_table=11
                     /translation="MVNDDHGFAVMYRLRLKGRGGAERIAAAVGSDPASVGAALEDLAE
                     RGLALYREGRISGWLLTPEGRLECERRVGRYRASLDTDVVAKLYDDDFLGLNQEFKALC
                     ARSQGPAHDHGDTLRRLESVHGGASRLLRQFAVHLTWFPVAYTSRFDTALERFREGDRA
                     ALVQPFTDSYHDVWMELHEDLLLVLARRREDED"
     source          1..26000
                     /db_xref="taxon:310350"
                     /host="Theonella sp."
                     /mol_type="genomic DNA"
                     /organism="Nocardiopsis sp."
                     /strain="HB-J378"
     misc_feature    1..26000
                     /note="nocardiopsistin biosynthetic gene cluster"
     protocluster    1..26000
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11078:12125]"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11079..12125
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="1"
     protocluster    1..26000
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[3049:5529]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="2"
                     /t2pks_malonyl_elongations="8|9 (Score: 657.2; E-value:
                     1.8e-200)"
                     /t2pks_molecular_weights="propionyl-CoA_8 (Da): 411.379"
                     /t2pks_molecular_weights="propionyl-CoA_9 (Da): 453.416"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="propionyl-CoA (Score: 745.0; E-value:
                     9.75e-137)"
                     /tool="antismash"
     proto_core      3050..5529
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="2"
                     /t2pks_malonyl_elongations="8|9 (Score: 657.2; E-value:
                     1.8e-200)"
                     /t2pks_molecular_weights="propionyl-CoA_8 (Da): 411.379"
                     /t2pks_molecular_weights="propionyl-CoA_9 (Da): 453.416"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="propionyl-CoA (Score: 745.0; E-value:
                     9.75e-137)"
     cand_cluster    1..26000
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2pks2 or ksIII)"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="neighbouring"
                     /product="PKS-like"
                     /product="T2PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..26000
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002504"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..26000
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PKS-like"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2pks2 or ksIII)"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(799..972)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QOP59267.1"
                     /transl_table=11
                     /translation="MSRELALMPRFDCDGGSRSVSESGVRRVRGRTVRSSLPLKTIQFV
                     YANYKHGIYVRR"
     misc_feature    complement(862..864)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             1128..2609
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 536.9; E-value:
                     8.7e-163)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 569.8; E-value: 1.1e-173)"
                     /gene_kind="biosynthetic-additional"
                     /product="FAD-binding monooxygenase"
                     /protein_id="QOP59268.1"
                     /transl_table=11
                     /translation="MESPVIIVGAGPAGMMLAGELALAGVRPLVLERLAEPSGESRGLG
                     FGPRTMEIFEQRALLARFGEITPRTAGHFGGVPLDFSVVDGAHFSVDSVPQSRTEEVLG
                     GWLEDLGVRIRRGVEVTGLSQDEYGVDVETVGPGGPETIRASYLVGCDGGRSTVRTEAG
                     FDFPGTPPTLEMYIADVAGCSVRPRPIGEPVAGGMAMAAPIAEGVDRIVVCELGNEPGA
                     RSSTPLFGEVAASWKRITGEDISHGTPRWVSSFTDSARLVSEYRRGRVLLAGDAAHVHL
                     PAGGQGMNVGVQDAFNLGWKLAARVRGQADDALLDTYHSERHPVGERLLRNTRAQGTLI
                     LGGDASRPLREVLTELVAHDDVAHHLAAMVAGLDVRYDVGPDSHPLSGLRLPRTHLVVE
                     GRTTTTAELLRTGRGLLLDLSEEPGQARTALPWSDRVDTVSARLSDQDANGPLAATVSV
                     LVRPDGHVAWTSLATADLTGALNRWFGPPTDQPAA"
     CDS             2662..2988
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 150.2;
                     E-value: 2.9e-46)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C17/C2-C19 (Score: 163.4; E-value: 1.3e-50)"
                     /gene_kind="biosynthetic-additional"
                     /product="polyketide synthesis cyclase"
                     /protein_id="QOP59269.1"
                     /transl_table=11
                     /translation="MHSTLIVARMSGEHEQDIAKLFGAFDQTEMPELMGTLRRQLFTFN
                     GLYFHLQDFGSEGSASIDRARSHPLFQQISADMRPFVEAYDPATWRSPADAIATRFYRW
                     ERQA"
     CDS             3050..4318
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (6-416). E-value:
                     6e-58. Score: 188.5. Matches aSDomain:
                     nrpspksdomains_QOP59270.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 501.2; E-value:
                     4.1e-152)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     764.0; E-value: 8.4e-233)"
                     /gene_kind="biosynthetic"
                     /product="beta-ketoacyl-ACP synthase"
                     /protein_id="QOP59270.1"
                     /sec_met_domain="t2ks (E-value: 1.3e-236, bitscore: 775.8,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRRAVITGIGVVAPGGVGRKEFWSLVSEGRTATRALSFFDPSPF
                     RSRIAAEADFTPELHGLTSQEIRRMDRSAQFAVVASREAVQDSGLEVGEALAHRTGVSI
                     GSAVGASMNLEREYRAASDDGRLSLVDHAYTVPQLYGWFVPSTLAAETAWATGAQGPAT
                     VVSTGCTSGLDSVGYAVDLIREGTADVMIAGGTDAPISPITVACFDAIRATSPNNDDPE
                     HASRPFDNTRNGFVLAEGCAVLVVEELEHARRRGAQVYAEIRGFASRANAYHMTGLRPD
                     GREMADAIRAAMAEARVAPEEIDYVNAHGSGTKQNDRHETGAFKESLGEHAYRTPVSSL
                     KSMVGHSLGAIGTIEIAACALAIRNDVVPPTANLTTPDPECDLDYVPVTAREWRTDTVL
                     TVGSGFGGFQSAMVLSDVEAGAR"
     aSDomain        3068..4297
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QOP59270.1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="6.00E-58"
                     /label="QOP59270.1_PKS_KS.1"
                     /locus_tag="QOP59270.1"
                     /protein_end="416"
                     /protein_start="6"
                     /score="188.5"
                     /tool="antismash"
                     /translation="ITGIGVVAPGGVGRKEFWSLVSEGRTATRALSFFDPSPFRSRIAA
                     EADFTPELHGLTSQEIRRMDRSAQFAVVASREAVQDSGLEVGEALAHRTGVSIGSAVGA
                     SMNLEREYRAASDDGRLSLVDHAYTVPQLYGWFVPSTLAAETAWATGAQGPATVVSTGC
                     TSGLDSVGYAVDLIREGTADVMIAGGTDAPISPITVACFDAIRATSPNNDDPEHASRPF
                     DNTRNGFVLAEGCAVLVVEELEHARRRGAQVYAEIRGFASRANAYHMTGLRPDGREMAD
                     AIRAAMAEARVAPEEIDYVNAHGSGTKQNDRHETGAFKESLGEHAYRTPVSSLKSMVGH
                     SLGAIGTIEIAACALAIRNDVVPPTANLTTPDPECDLDYVPVTAREWRTDTVLTVGSGF
                     GGFQSAMVLSD"
     CDS             4315..5529
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (6-364). E-value:
                     2.8e-21. Score: 67.7. Matches aSDomain:
                     nrpspksdomains_QOP59271.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 632.6; E-value:
                     3.7e-192)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 657.2; E-value: 1.8e-200)"
                     /gene_kind="biosynthetic"
                     /product="ketosynthase chain-length factor"
                     /protein_id="QOP59271.1"
                     /sec_met_domain="t2clf (E-value: 5.3e-196, bitscore: 641.5,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKATAVVTGIGVAAPNGLRTEEFWASTCAGLSGIDTVSRFDPASY
                     PSRLAGQVRGFDAKEHLPSRLLPQTDHMTQMGLAVADWALADSGVDTSTLPEYGMGVVT
                     AASAGGYEFGQTELEKLWSRGPRHVSAYQSFAWFYAVNTGQISIRNKMRGPCQTLVSDQ
                     AGGLDAIGQARRRVRGGVPLVMTGGVDGSICPWGWLGHLSSGRVSTAEAPERAFLPFDA
                     AAGGHVVGEGGAHLVVEEAGAAQARGARPYGRIAGYSATFDPAPGSGLPSALPRAIEQA
                     LSDAGKAPEEVGAVFADAAAVPELDRAEAEAISGVFGPGGVPVTAPKTMTGRLHAGGGP
                     LDVATALLALRDGVIPPTVNTELSSSYDIDLVSGEARESAELDTVLVLARGQGGFNSAM
                     VLCAS"
     aSDomain        4333..5406
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QOP59271.1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.80E-21"
                     /label="QOP59271.1_PKS_KS.1"
                     /locus_tag="QOP59271.1"
                     /protein_end="364"
                     /protein_start="6"
                     /score="67.7"
                     /tool="antismash"
                     /translation="VTGIGVAAPNGLRTEEFWASTCAGLSGIDTVSRFDPASYPSRLAG
                     QVRGFDAKEHLPSRLLPQTDHMTQMGLAVADWALADSGVDTSTLPEYGMGVVTAASAGG
                     YEFGQTELEKLWSRGPRHVSAYQSFAWFYAVNTGQISIRNKMRGPCQTLVSDQAGGLDA
                     IGQARRRVRGGVPLVMTGGVDGSICPWGWLGHLSSGRVSTAEAPERAFLPFDAAAGGHV
                     VGEGGAHLVVEEAGAAQARGARPYGRIAGYSATFDPAPGSGLPSALPRAIEQALSDAGK
                     APEEVGAVFADAAAVPELDRAEAEAISGVFGPGGVPVTAPKTMTGRLHAGGGPLDVATA
                     LLALRDGVIPPTVNTELS"
     CDS             5588..5839
                     /NRPS_PKS="Domain: PP-binding (30-77). E-value: 2.3e-10.
                     Score: 32.8. Matches aSDomain:
                     nrpspksdomains_QOP59272.1_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 99.2; E-value:
                     1.8e-30)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 102.5; E-value: 2.2e-32)"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl carrier protein"
                     /protein_id="QOP59272.1"
                     /sec_met_domain="PP-binding (E-value: 8.9e-11, bitscore:
                     32.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQMTINDLKTVLVKAAGEGEGAGLDGDIADMRFEELGYDSLAL
                     MEAGSLIEHEHGIRIDEEELAGAETPGSLLKTINAYLA"
     aSDomain        5678..5818
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QOP59272.1_PP-binding.1"
                     /evalue="2.30E-10"
                     /label="QOP59272.1_PP-binding.1"
                     /locus_tag="QOP59272.1"
                     /protein_end="77"
                     /protein_start="30"
                     /score="32.8"
                     /tool="antismash"
                     /translation="ADMRFEELGYDSLALMEAGSLIEHEHGIRIDEEELAGAETPGSLL
                     KT"
     CDS             6005..6790
                     /NRPS_PKS="Domain: PKS_KR (7-163). E-value: 2.7e-11. Score:
                     35.6. Matches aSDomain: nrpspksdomains_QOP59273.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     259.2; E-value: 6.1e-79)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 465.9; E-value: 7.7e-143)"
                     /gene_kind="biosynthetic-additional"
                     /product="keto-reductase"
                     /protein_id="QOP59273.1"
                     /sec_met_domain="adh_short (E-value: 3.2e-38, bitscore:
                     122.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEQDLPVALVTGATSGIGHAVATELAERGKQVFLCARDAEAVDT
                     TVQQFRDKGYDVGGTTCDVRSADDVRAFVTEAVERFGTVDILVNNAGRGGGGVTADIPD
                     ELWFDVIDTNLNSVFRVTREVLTTGGLRHKDRGRIINIASTAGKQGVVLGAPYSASKHG
                     VVGFTKALGNELAPTGITVNAVCPGYVETPMAEQIRRRYAAHEQTTEEAILQRFQAKIP
                     LGRYSSPEEVAGMVGHLTTRAADSITSQAINVCGGLGNF"
     aSDomain        6026..6493
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QOP59273.1_PKS_KR.1"
                     /evalue="2.70E-11"
                     /label="QOP59273.1_PKS_KR.1"
                     /locus_tag="QOP59273.1"
                     /protein_end="163"
                     /protein_start="7"
                     /score="35.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGATSGIGHAVATELAERGKQVFLCARDAEAVDTTVQQFRD
                     KGYDVGGTTCDVRSADDVRAFVTEAVERFGTVDILVNNAGRGGGGVTADIPDELWFDVI
                     DTNLNSVFRVTREVLTTGGLRHKDRGRIINIASTAGKQGVVLGAPYSASKHG"
     CDS_motif       6032..6094
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QOP59273.1_0001"
                     /evalue="2.60E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="QOP59273.1"
                     /protein_end="30"
                     /protein_start="9"
                     /score="20.1"
                     /tool="antismash"
                     /translation="LVTGATSGIGHAVATELAERG"
     CDS             6831..7778
                     /NRPS_PKS="Domain: Polyketide_cyc2 (10-150). E-value:
                     1.9e-17. Score: 55.9. Matches aSDomain:
                     nrpspksdomains_QOP59274.1_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc (171-268). E-value:
                     8.8e-09. Score: 27.6. Matches aSDomain:
                     nrpspksdomains_QOP59274.1_Polyketide_cyc.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 416.6; E-value:
                     1e-126)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 448.4; E-value: 2.4e-137)"
                     /gene_kind="biosynthetic-additional"
                     /product="cyclase/dehydrase"
                     /protein_id="QOP59274.1"
                     /transl_table=11
                     /translation="MPLPQENGTREVEHTSVIQAPAEDVYRLIADVQDWPLIFPPSVHV
                     EHESRSGQEEVIRIWATANGLPKTWTSRRRLDPRGMRVDFRQVVSSPPVASMGGAWTVE
                     ALAGGRSLVRLSHDYRALDQADLDWIDQAVDRNSESELDALKRSAEAGLRGNRTRLTFE
                     DTVRAKGRAEDLYAFVNDAGLWRERLPHVARVVLTEDTPGLQTLEMDTRSQDGSVHTTE
                     SVRVCFPYERIVYKQLRVPPLMTLHTGAWSFTQEGEEAVVTSRHTVVINEARIGPLLGA
                     DKSLEDARDFVRSALGRNSLATMNLAKDHVESGG"
     aSDomain        6861..7280
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QOP59274.1_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.90E-17"
                     /label="QOP59274.1_Polyketide_cyc2.1"
                     /locus_tag="QOP59274.1"
                     /protein_end="150"
                     /protein_start="10"
                     /score="55.9"
                     /tool="antismash"
                     /translation="EVEHTSVIQAPAEDVYRLIADVQDWPLIFPPSVHVEHESRSGQEE
                     VIRIWATANGLPKTWTSRRRLDPRGMRVDFRQVVSSPPVASMGGAWTVEALAGGRSLVR
                     LSHDYRALDQADLDWIDQAVDRNSESELDALKRSAE"
     aSModule        6861..7634
                     /domains="nrpspksdomains_QOP59274.1_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_QOP59274.1_Polyketide_cyc.1"
                     /incomplete
                     /locus_tags="QOP59274.1"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        7344..7634
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QOP59274.1_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="8.80E-09"
                     /label="QOP59274.1_Polyketide_cyc.1"
                     /locus_tag="QOP59274.1"
                     /protein_end="268"
                     /protein_start="171"
                     /score="27.6"
                     /tool="antismash"
                     /translation="AEDLYAFVNDAGLWRERLPHVARVVLTEDTPGLQTLEMDTRSQDG
                     SVHTTESVRVCFPYERIVYKQLRVPPLMTLHTGAWSFTQEGEEAVVTSRHTV"
     CDS             7783..9261
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 461; E-value:
                     8.9e-140)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 474.4; E-value: 1e-144)"
                     /gene_kind="biosynthetic-additional"
                     /product="oxidoreductase"
                     /protein_id="QOP59275.1"
                     /transl_table=11
                     /translation="MDVVVVGAGPVGLMLAGELRLGGADVVVLERLTAPIEESRASQLG
                     PRTAELFLQRGLWEALGDPPQENTGHFGGIPLAAGGADGPVPGNRKVPQPRTERILHDW
                     ATGLGAKVLRDHEVVSVEQTADEAVLTVRTRGVTASWRARHVVGCDGAESVVRRDAGIP
                     FDGTPAEREVLRADLKGARVSNRRFERLPRGVAVSSTSPEGVTRVMVHEYDRAPGTAPP
                     SFAEVAAAWERVTGEDVSGATALWTDSFDDAQGQAAVYRRGRLFLAGDAARVHVPAGGQ
                     SLNTGLHDAVNLGWKLAARVHGRVGDDLLDTYDAERRRAGQRVLANVAVQNLLLFGGSR
                     YDRMRDLFGNLLETPVFAESLADMVNGVGERYPAPHEKPDDPLLGRRLPPCPKPRGTAF
                     LPPDRGVLLLDSDGPLARASREGAAPWVDRVDVIDERDLVGLLPSPVRAALVRPDGHVA
                     WTDRCDRSLGDALHRWFGPPGHAPEGLSDVREGM"
     CDS             9271..10866
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 692.1; E-value: 8.4e-210)"
                     /gene_kind="biosynthetic-additional"
                     /product="methylmalonyl-CoA carboxyltransferase alpha"
                     /protein_id="QOP59276.1"
                     /transl_table=11
                     /translation="MSTSSELSALAPEPVPSWRRASSELLSTRERLASGPGAKATQAQH
                     DKGKLTVRERLDVLFDEGTFVEVGPLRRHRATGFGLEDKRPHTDGVVTGWGTVHGRRVF
                     CYAHDFRIFGGALGEAHAAKIHRIMDLAIAAGAPLVSLNDGAGARIQEGVTALAGYGGI
                     FQRNTRASGMIPQISVMLGPCAGGAAYSPALTDFVFMVRGISQMFITGPDVVRSVTGEE
                     VTHDGLGGADVHAAVSGVCHVIHDDEHACLEDVRYLLSLLPQNNRESAPREPCDDPVDR
                     RSTRLLDLVPPDGGRSYDMRRVIGEIVDDGEFMEIQEGWARNIVCVLARLDGHVVGIVA
                     NQPSVMAGVLDIDASKKGAGFVQTCDSFNIPLVSLVDVPGFLPGVEQEHQGIIRHGAQL
                     LYAYCNATVPRVSVILRKAYGGAYIVMDSQSVGADLTYAWPLNEIAVMGAGAAADVIFR
                     RRIAEADDPGALRELLIKEYESELMHPYHAAEHGLVDDVIPPDETREVLVRALRALRAK
                     HADLPSRKHGNPPM"
     CDS             11079..12125
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: ksIII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 121.5; E-value: 6.6e-37)"
                     /gene_functions="biosynthetic-additional (t2pks) KSIII
                     (Score: 448.9; E-value: 2.5e-137)"
                     /gene_functions="biosynthetic-additional (t2pks) KSIII
                     ABC00733.1_Cosmomycin_propionyl-CoA (Score: 383.0; E-value:
                     9.75e-137)"
                     /gene_kind="biosynthetic"
                     /product="3-oxoacyl-ACP synthase"
                     /protein_id="QOP59277.1"
                     /sec_met_domain="ksIII (E-value: 1.6e-92, bitscore: 300.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSPLYVASCALHLPTVVSAAEELAAGHCEQETVTATGATGVAVA
                     HEESAPRMAVRAASLAMERGGREPADISLLLHASVFFQGHEVWAPASYIRHEALGVGGQ
                     SIDVSQASNGAMAAIDLAAAYLAADPACGEALVTTGDRCPSPGFDRWRSDPGTVYGDGG
                     TALVLSRTDGFARLRSLVTVSDPGLERIHRGDAPFTSAPFTHRSTVDLEAAKREYIAAE
                     GLSPTVARVNAGQNGAVKHALAEADVELGDISRVVLPHLGLKRLRAGFLRRLDLDPQIT
                     TWPWSRGVGHLSAGDPIAGLDHLVGTGALGPGDLCLLVSVGAGFTWSCAVVEMLHSPGW
                     ASGSGNGE"
     CDS             12122..13135
                     /NRPS_PKS="Domain: PKS_AT (21-303). E-value: 2.3e-70.
                     Score: 229.2. Matches aSDomain:
                     nrpspksdomains_QOP59278.1_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 255.3; E-value: 2.2e-77)"
                     /gene_functions="biosynthetic-additional (t2pks) AT (Score:
                     417.7; E-value: 7.8e-128)"
                     /gene_functions="biosynthetic-additional (t2pks) AT
                     BAB72049.1_Aklavinone_propionyl-CoA (Score: 362.0; E-value:
                     3.87e-128)"
                     /gene_kind="biosynthetic-additional"
                     /product="malonyl CoA-acyl carrier protein transacylase"
                     /protein_id="QOP59278.1"
                     /sec_met_domain="PKS_AT (E-value: 9e-71, bitscore: 229.2,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMTAAETRTERALPSPVALLLPGQGAQHVRMAAGLHGEVPTFTE
                     AVEEVFAAMGREGRALRSDWLSARPRVHIDHATRAQPLLFAVDYGLCRLLLGQGVRPAA
                     LLGHSMGEVVAAVVAGVFSLEDACALALDRVERVLRAPAGGMAAVSATPRELEPHLHSG
                     VAVGGVNAPRQTVLAGPETGLDTVLGQLRERGFSLRRIPSLTGFHSPLLDEVLKGSEDL
                     FEGVRTRAPEIPVYSGYTAALLTADQAGDPSFWAGQPAAPVMFWPALERLLADGPFTLV
                     EAGPGQGLSQLARRHPAVRAGHSAVLSMLPARPGTAEDDLRSVRTTLEKLRNREAP"
     CDS_motif       12182..12229
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QOP59278.1_0001"
                     /evalue="8.30E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="QOP59278.1"
                     /protein_end="36"
                     /protein_start="20"
                     /score="12.2"
                     /tool="antismash"
                     /translation="LLPGQGAQHVRMAAGL"
     aSDomain        12185..13030
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QOP59278.1_PKS_AT.1"
                     /evalue="2.30E-70"
                     /label="QOP59278.1_PKS_AT.1"
                     /locus_tag="QOP59278.1"
                     /protein_end="303"
                     /protein_start="21"
                     /score="229.2"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LPGQGAQHVRMAAGLHGEVPTFTEAVEEVFAAMGREGRALRSDWL
                     SARPRVHIDHATRAQPLLFAVDYGLCRLLLGQGVRPAALLGHSMGEVVAAVVAGVFSLE
                     DACALALDRVERVLRAPAGGMAAVSATPRELEPHLHSGVAVGGVNAPRQTVLAGPETGL
                     DTVLGQLRERGFSLRRIPSLTGFHSPLLDEVLKGSEDLFEGVRTRAPEIPVYSGYTAAL
                     LTADQAGDPSFWAGQPAAPVMFWPALERLLADGPFTLVEAGPGQGLSQLARRHPAVRAG
                     H"
     CDS_motif       12416..12523
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QOP59278.1_0002"
                     /evalue="1.00E-18"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="QOP59278.1"
                     /protein_end="134"
                     /protein_start="98"
                     /score="59.5"
                     /tool="antismash"
                     /translation="GVRPAALLGHSMGEVVAAVVAGVFSLEDACALALDR"
     CDS             complement(13161..13631)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 67.6; E-value: 1.4e-20)"
                     /gene_kind="regulatory"
                     /product="MarR family transcriptional regulator"
                     /protein_id="QOP59279.1"
                     /transl_table=11
                     /translation="MGEAQALDLDLVKGALRFVPMLEVYYRRAHTEMPKDLQDLFDRYR
                     LTGRHGGVLVQLAHEPELGVGELSARLSVGLSTVSELVGDLEWAGLVVRRKDPANRRRV
                     LVALAEDHRETMRVFIAKRAAPLLRVFEHLDPRDSQGFAAGLEAWAKEVRSG"
     CDS             14338..15165
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     269.9; E-value: 8.9e-82)"
                     /gene_kind="regulatory"
                     /product="SARP family transcriptional regulator"
                     /protein_id="QOP59280.1"
                     /transl_table=11
                     /translation="MTFRVLGMLEVGLDDRTYSPTGGKIRQLLALFLCRANEVVSPEAL
                     MEELWGDAPPRSAMVTLQSHVYQLRRALDRAFPEAGLGRALVTRSRGYMFSVPEGRVDA
                     LEFERLVLQARRLAERGRPTEALEASRAARNLWRGEVLSDVQRGPLLNAHAVRLAELRL
                     TAIRACVAADMDLFRYGELVPQLRTLVAYYPFDEWFHVQLIRALAGDGRRGDALLSYDH
                     VCRLLDEELGLEPSAELRRLRAEILSGDVRRFRGRPARDGSERSPSPDGVHAS"
     misc_feature    14986..14988
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(15098..16360)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 194.7; E-value:
                     5.2e-59)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 103.3; E-value: 3.6e-32)"
                     /gene_kind="biosynthetic-additional"
                     /product="FAD-binding oxygenase"
                     /protein_id="QOP59281.1"
                     /transl_table=11
                     /translation="MMLGLLLARAGVDVTVLEKHADFFNDFRGDTVHPSTLQVLEDIGL
                     GEEVNRIPHRKVRKVTVGSEHAGTIEADLGSVPGSHPYISMIPQWDFLDMLAREARRYP
                     NFRLLMNATSTLLLRKGDAVRGVEYTDPEGTHRLRSVLTVSADGRNSRLREFAGLRPRR
                     LGSPMDVLWLRVSRASEQVEGLNGRTGEGTMAFAIDRGDYWQIAYVIRKGGFDALRREP
                     VERLQERLRELLPFLGDRVSEVSDWEKVALLNVGLDRLERWYTPGYLCIGDAAHAMTPV
                     GGVGINLAVQDAVAAANILAGPLSRAQRHPDRFERTFNPEFLARVQRRRWFPDTGTQRV
                     QQFIQRELFGQVIPRPESEPDASAPGSSAPDSSLTRAVLSSETGSKAATWLYSRIITRV
                     MMRGLRPETVTSPSRPELVVP"
     CDS             complement(16496..17140)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 62.6; E-value: 7e-19)"
                     /gene_kind="other"
                     /product="NmrA-family oxidoreductase"
                     /protein_id="QOP59282.1"
                     /transl_table=11
                     /translation="MRRTLHVTVFGATGGTGRHVVAQALRAGHRVQAVVRDPGRLPLSH
                     VRLETVRMDTPDLGRLAQTLAHGDAVISALGASARGGFPASTWISAILRAVEDHPRPRL
                     VAVSASPLGPPPARESMVIKKVVTPLVGWVFRDAYRDLAVMERSLSASDTDWTILRPPR
                     LTDGPLTGLHRMSLGTNVSGGLSISRADLAHAALAALEDPATLKQAVGVSR"
     CDS             18022..19311
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 334.9; E-value: 1.4e-101)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 55.5; E-value: 1.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /product="halogenase"
                     /protein_id="QOP59283.1"
                     /sec_met_domain="Trp_halogenase (E-value: 7.1e-22,
                     bitscore: 68.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDAPREDTVYDAVIVGGGPGGAACAMTLARAGRSVLLLERTVFP
                     RFHIGESLLTYTVDVLARLGVLDRVLASGFVVKRGVELSGPEGNSYRIGFDEIGEGYRD
                     WTLQVERAEFDQILLDAAAAEGAKVVEGARVTAPVLSGDRVSGVRYTLDDGSSSTVRAH
                     YVVDASGRTGVISRALGLRRNDESIRMVAAFKHYAGTHELHNPGAKGDIQLGNHPDGWV
                     WGIPIRKDVISIGTVVPVDVMRQGRAEEVFEEHLSRIPRIHARTRGARVVRELTGETDY
                     SHYSERLAGPGYYIVGDAGCFTDPIFSAGVFLALVTGMESAACVNASLDGAGPGREREI
                     ATSYEDFCKTGFDTYHRLIRAFYDNGYSVYRYLTGAIDDPTQLGGILRLLNGDFWNEHD
                     PVSRKLREVPQWGMFESFTPDYNCPVHGDR"
     CDS             19328..20674
                     /codon_start=1
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 341.1; E-value:
                     1.3e-103)"
                     /gene_kind="transport"
                     /product="transporter"
                     /protein_id="QOP59284.1"
                     /transl_table=11
                     /translation="MESIPTLTAHVFAALAAIVLVASVFGRIAVLLRQPRVVGEMVAGV
                     LMGPSLLGWLLPDVQEALFPAEVRPALYLLSMIGLVFFMFLVGAGIRHGVLDRRSTRGA
                     LSVGVVGVVVPLALGVTVAWALADQISDPGTPRLQVSLLLGGALTVTAFPMLARILNER
                     GMQSSRLGAVTLLAASVDDAAAWIVLAVILALAFGGSMAGVAASLVGVAVFTVVMLKLA
                     PRLLAPIARSVERNGHLTPGALAVVVLLILGAAWTTHELGIHFVFGGFIVGISLPASPA
                     LRECVRNRLMDMNVGLLLPVFFIYTGLNTDLGGLVSGSALLAVIAITAVAFIGKYLSCL
                     FVMRALGHSWRVASAAGGLMNARGLMVLIFINIGLEHGVLSQDLFSILVLVAVVTTVAA
                     LPIYRLSLPDSLEAAERLDTADPDPEPEPATPPREAREKEAETAMANEP"
     CDS             22624..23367
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 138.1; E-value: 5.7e-42)"
                     /gene_kind="regulatory"
                     /product="GntR family transcriptional regulator"
                     /protein_id="QOP59285.1"
                     /transl_table=11
                     /translation="MGRQPRYLWLAEQLRGPILSGELPPGTRLPSRTRLARSYRVSEQI
                     SRTALRLLVTEGLVESRPGSGYYVRTVPELFRICRTDSSSGSGLGRLSREAIGTEQEQC
                     APPLSLRLRLREGEPVYRTTSRGLSSELPITLHRSWEPASLTAGTLRTPFDSSPGSGLL
                     ERLSAAGHPVDRVVEEVGVRALRDSEASLLGSAPGIPVLVVERTHFSGNRPVETSDLIG
                     SSEQCRLLYKLTLARPRRPGDPRRY"
     CDS             complement(23592..24653)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QOP59286.1"
                     /transl_table=11
                     /translation="MSNRLPTLAVVGATGAVGTVMLDILTQRENVWGEIRLVASPRSAG
                     KVLRVRGEDVVVQALAPEVFDGVDVAMFDVPDEVSKEWAPVAASRGAVAVDNSGAFRMD
                     PDVPLVVPEVNADQVRNRPRGIISNPNCTTLSMIVAIGALHRAYGVTDLVVSSYQAASG
                     AGQEGIDTLRDQMAKAGADRSLGDTAGDVRAAVGELGPFPAPLAYNVVPWAGSLKDGGW
                     SSEELKVRNESRKILGLPDLRVSATCVRVPVITTHSLVVHASFAEEVPADAARELLGSA
                     EGVQVQDDPANGEFPTPADVVGTDPTWVGRIRQSLDDPRSLDLFLCGDNLRKGAALNTA
                     QIAEVVAGEFTRA"
     CDS             complement(24650..25990)
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="QOP59287.1"
                     /transl_table=11
                     /translation="MDEDVCGYTPFHCLDPNSSGASIVALIVQKYGGSSVADAEAIKRV
                     AQRIVAQKKAGYDVVVVVSAMGDTTDELLDLAEQVSPMPPARELDMLVTAGERMSMALV
                     AMAIENLGFEARSFTGSQAGVITTSLHGNAKIIDVTPGRIQEAVGEGAICIVAGFQGVS
                     QDTKDITSLGRGGSDTTAVALAAALEADACEIYSDVDGVFTADPRIVPTAQRIPQVSYE
                     EMLEMAASGTKILHLRCVEYARQYNIPLHVRSSFSQKPGTWVVPEVEESEGMEQPIISG
                     VSHDRSEAKITVVGVPDKIGEAATIFRALADAEINIDMIVQNVSAVSTSRTDISFTVPK
                     DFGKEAVAALKKVQDKVGFESLRYDDKIGKVSLIGAGMRSYPGVTARFFDAIAGSSTNV
                     EMISTSEIRISVIVEEDQIDAAVRAAHSEFQLDADQVEAVVYGGTGR"
ORIGIN
        1 atggtgaacg acgaccacgg cttcgccgtc atgtaccggt tgcgcttgaa gggaaggggc
       61 ggggctgagc ggatagccgc cgcggtgggc tccgacccgg cgtcggtcgg cgccgcgctg
      121 gaggacttgg ccgaacgcgg tctggccctg taccgcgaag gccggatcag cggttggctg
      181 ctgaccccgg agggccgtct ggagtgcgag cggcgggttg gtcggtaccg cgcgtccctg
      241 gacacggacg tggtcgccaa gctctacgac gacgacttcc tcggtctcaa ccaggagttc
      301 aaggccctgt gcgcccgctc ccagggtccc gcccacgacc acggcgacac cctgcgccgg
      361 ttggagagcg tacacggtgg tgccagccgg ctcctccgac agttcgccgt ccacctcacg
      421 tggttccccg tcgcgtacac gagccggttc gacacggcct tggaacgctt ccgggagggg
      481 gaccgggccg ccctggtcca gccgttcacg gattcgtacc acgacgtgtg gatggaactg
      541 cacgaggacc tgctgctcgt ccttgcccgt cgacgcgagg acgaggactg agcaggacgg
      601 cgtcccctgg atgacggccg gtccttgaag ccctccggag ccccgggtgc ggcggtgtcc
      661 cgttggtagg cccgcccacc agggcttctt cttgtccgga gcgccgcccc agggtcgcga
      721 ccagtccttt cccggcggga aagggccgaa cgccgaaccc gcaggaagag aaaccgcagg
      781 ccaggcattg tccgtccact atctgcggac atagattccg tgcttgtaat tcgcatacac
      841 gaactgtatg gtcttcaagg gtaacgagga acggacagtt cggccccgaa ctcgccgaac
      901 acccgactct gacacgctcc gtgacccccc gtcacaatcg aagcgcggca tcaaagccaa
      961 ttcccgcgac accttgacct ctccagggtt gccggcaacc cgacattcac cgactccgcg
     1021 tgaatgtcag tcgaattcaa atcaccacgg cgcacaccgt cccatcaagg ggagcagtgg
     1081 gccttctgtt gcgattcccc tgaacagtca acggaaaaga gggtttcatg gaatcccccg
     1141 tcatcattgt tggggcaggc ccggcgggga tgatgctcgc cggagaactc gccctggccg
     1201 gggttcggcc cctggtcctg gaacggttgg cggagccgtc cggagaatcg cgcggcctgg
     1261 gcttcggacc gcgcacgatg gagatcttcg aacagcgcgc gctcctggcg cggttcggtg
     1321 agatcacccc ccgcaccgcc gggcacttcg gcggtgtccc cctcgacttc tccgtcgtgg
     1381 acggggcgca cttcagcgtc gacagcgttc cgcagtcccg caccgaggag gtcctgggcg
     1441 ggtggttgga ggacctggga gttcgcatcc gccgtggagt cgaggtcacc ggcctgtccc
     1501 aggacgagta cggcgtggac gtcgagacgg tcggtcccgg gggaccggag accatacgcg
     1561 cctcctatct ggtgggatgc gacggcggtc gcagcaccgt ccgcaccgag gcggggttcg
     1621 acttccccgg gacgcctccg acgctggaga tgtacatcgc cgacgtcgcc ggatgctcgg
     1681 tgcggccccg ccccatcggt gagcccgtcg ccggtgggat ggccatggcg gctccgatcg
     1741 ctgagggagt cgaccggatc gtggtgtgcg agctgggcaa cgagcccggg gcccgctcct
     1801 cgacccctct cttcggcgag gtggccgctt cctggaaacg gatcaccggt gaggacatct
     1861 cccacggcac cccgcggtgg gtcagcagct tcaccgactc cgcacggctg gtgagcgagt
     1921 accgccgagg tcgggtcctg ctcgcgggcg acgccgcaca cgtccacctg ccggccgggg
     1981 gccaggggat gaacgtgggc gtccaggacg cgttcaacct cggctggaag ctggccgcgc
     2041 gcgtgcgcgg ccaggcggac gacgcgctcc tcgacaccta ccactccgaa cgtcacccgg
     2101 tcggggaacg gctgctgcgc aacacacgcg cccagggcac gctcattctc ggcggagacg
     2161 cctcgcgccc cctgcgcgag gtgctcacgg aactggtcgc ccacgacgac gtggcccacc
     2221 acctggccgc gatggtggcc gggctggacg tgcgctacga cgtgggtccc gacagccacc
     2281 cgctgagcgg tctgcgcctt ccgcggaccc acctcgtggt cgagggccgc acgaccacga
     2341 ccgccgaact gctgcgcacc ggacgcggac tcctgctcga cctgtcggag gagcccggcc
     2401 aggcaaggac ggctctgccg tggtccgacc gggtggacac ggtcagcgcc cgtctgtccg
     2461 atcaggacgc gaacggcccg ctggccgcga ccgtgagcgt tctggtgcgc cccgacgggc
     2521 acgtcgcctg gacctccctg gcgaccgcgg acctcaccgg cgccctgaat cgctggttcg
     2581 gtccgccgac ggaccagccc gccgcctgag accgcaggcc ggccaccaca tgacgcacca
     2641 cggaccagag gagacccgcc catgcacagc accctgatcg tcgcccgcat gtccggagag
     2701 cacgaacagg acatcgcgaa actgttcggt gccttcgacc agaccgagat gcccgagctg
     2761 atgggaactc tgcgtcgtca gctgttcacc ttcaacggtc tctacttcca cctccaggac
     2821 ttcgggtccg aggggtcggc gtcgatcgac cgcgctcgct cccacccgct gttccagcag
     2881 atcagcgcgg acatgcgtcc cttcgtcgag gcgtacgacc cggccacttg gcgctctccc
     2941 gccgacgcca tcgccacacg cttctaccgc tgggagcgtc aggcgtgacg ccggttccga
     3001 caacgaccac acatgacgac aggagcggat ccgtgagagg gaggcagcga tgagccgccg
     3061 cgcggtgatc accggtatcg gtgtcgtggc cccgggaggc gtgggccgca aggagttctg
     3121 gagtctggtc agcgagggca ggacggcgac ccgggcactg tcgttcttcg acccctcgcc
     3181 cttccggtcg cgcatcgcgg ccgaggccga cttcactccc gaactgcacg gcctgaccag
     3241 ccaggagatc cgcaggatgg atcgttcggc ccagttcgcc gtcgtcgcct cccgcgaggc
     3301 ggtgcaggac agcggcctgg aggtggggga ggcgctcgct caccgtaccg gcgtcagcat
     3361 cggcagcgcc gtcggcgcga gcatgaacct cgaacgggag taccgggcgg ccagcgacga
     3421 cgggcggctc agcctcgtcg accacgccta caccgtcccc caactctacg ggtggttcgt
     3481 ccccagcacc ctggccgcgg agaccgcctg ggccacgggc gcgcagggac cggccaccgt
     3541 ggtctccacg gggtgcacct ccggcctgga ctcggtgggc tacgcggtcg acctcattcg
     3601 ggagggtacg gccgacgtga tgatcgccgg gggcaccgac gcccccatct cgcccatcac
     3661 cgtcgcctgt ttcgacgcca tccgcgccac cagcccgaac aacgacgatc ccgagcacgc
     3721 ctcgcgtccc ttcgacaaca cccgaaacgg cttcgtactc gcggagggct gcgcggtgct
     3781 cgtcgtggag gaactggagc acgcgcgcag acgcggcgct caggtgtacg ccgagatccg
     3841 gggtttcgcc tcgcgcgcca acgcctacca catgaccggg ctgcgccccg acggcaggga
     3901 gatggcggac gccatccggg ccgcgatggc cgaggcgcgt gtggccccgg aggagatcga
     3961 ctacgtcaac gcgcacggtt cgggcaccaa gcagaacgac cggcacgaga ccggcgcgtt
     4021 caaggagagc ctgggcgaac acgcctaccg gacacccgtc agttcgctca agtccatggt
     4081 gggccactcg ctgggcgcca tcggcacgat cgagatcgcc gcctgcgccc tggccatacg
     4141 caacgacgtc gtgcccccca cggcgaacct caccacaccc gaccccgaat gcgatctgga
     4201 ctacgtgccg gtcaccgcgc gcgagtggcg gaccgacacg gtcctgacgg tcggcagcgg
     4261 tttcggcggg ttccagagcg cgatggtgct ctctgacgtg gaggcgggtg ccagatgaag
     4321 gcgacggcgg ttgtcaccgg aatcggcgtg gccgcgccca acggcctgag gaccgaggag
     4381 ttctgggcct ccacgtgtgc gggcctcagc gggatcgaca cggtgagccg tttcgacccc
     4441 gcctcctatc cctcccgtct ggccgggcag gtccgggggt tcgacgcgaa ggagcacctg
     4501 cccagcagac tgctgccgca gaccgaccat atgacccaga tggggttggc cgtggcggac
     4561 tgggcactgg ctgactcggg agtggacacc tccactcttc ccgagtacgg gatgggcgtg
     4621 gtcaccgccg cctccgccgg aggttacgag ttcggccaga ccgaactgga gaaactctgg
     4681 agcaggggcc cccggcacgt gagcgcctac cagtccttcg cgtggttcta cgcggtcaac
     4741 accggccaga tctccatccg caacaagatg cgcggtccct gtcagacgct ggtcagcgac
     4801 caggcgggcg gactcgacgc gatcggccag gcgcgccgac gcgtgcgcgg cggcgtcccc
     4861 ctggtcatga cgggcggcgt cgacggctcg atctgtccct gggggtggct ggggcacctg
     4921 tccagcggcc gggtcagcac ggccgaggcc ccggagcgcg ccttccttcc cttcgacgcc
     4981 gccgcgggag gccatgtggt cggcgaggga ggggcccacc tggtcgtgga ggaggccggg
     5041 gccgcgcagg cacgcggtgc ccgcccctac gggaggatcg cggggtattc cgccaccttc
     5101 gaccccgcgc ccgggagcgg gcttccctca gcgctgcccc gcgcgatcga gcaggcgctc
     5161 tccgacgcgg gcaaggcccc cgaggaggtg ggggcggtgt tcgccgacgc ggcggccgtc
     5221 cccgagctgg accgggccga ggccgaggcg atcagtggcg tcttcgggcc cggaggagtc
     5281 ccggtgacag cacccaagac catgaccggc cgcctgcacg ctggcggcgg gcccctggac
     5341 gtcgcgacgg cgctgttggc gctgcgggac ggtgtcatac cgcccacggt caacaccgaa
     5401 ctctcctcct cctacgacat cgacctggtg tccggggagg cccgcgagag cgcggagctg
     5461 gacacggtcc tcgtcctggc gcgcggccag ggcggtttca acagcgcgat ggtcctgtgt
     5521 gcctcctgag gctcgcgcac agccctccct cacaccgaac gacacaacga tccgaaaggc
     5581 agtgcccatg acgacgcaga tgacgatcaa cgacctcaag acggttctcg tcaaggccgc
     5641 gggcgagggc gagggcgccg gcctggacgg cgacatcgcg gacatgcgct tcgaggagtt
     5701 gggctatgac tccctggccc tgatggaggc gggaagcctc atcgagcacg agcacggcat
     5761 ccgtatcgac gaggaggagc tcgccggggc ggagaccccc ggctcgctgc tgaagaccat
     5821 caacgcctac ctggcctagg gcgtgttccg agggcacggc ctgtgaccac aggtgtggtg
     5881 cgtgggcggc ggtgacgccg cccacaccgg cgggcgcggg cggcgaaccg gccgagggcg
     5941 tccatgcggg agccgcgccc cgcgcgaccg aaggactgag aagaggaaga ggaggagagc
     6001 aggtatgccc gagcaggatc tcccggtcgc actggtcacc ggggccacca gtggcatcgg
     6061 ccacgcggtc gccacggagc tggccgaacg gggtaagcag gtgttcctct gcgcccgtga
     6121 cgccgaggcc gtcgacacca ccgtccagca gttccgcgac aaggggtacg acgtcggggg
     6181 gaccacgtgt gacgtgcgtt cggccgacga cgtgcgtgcc ttcgtcacgg aggccgtgga
     6241 gcgcttcgga accgtcgaca tcctggtgaa caacgccggc cggggaggcg gcggggtgac
     6301 cgccgacatc cctgacgaac tgtggttcga cgtcatcgac accaatctca acagtgtctt
     6361 ccgggtcacc cgggaggtgc tcaccaccgg cggcctccgg cacaaggacc gcggccggat
     6421 catcaacatc gcctccaccg cgggcaagca gggcgtcgtg ctgggcgctc cctactccgc
     6481 ctccaaacac ggtgtcgtgg gcttcaccaa ggcgctgggc aacgagctgg cgcccacggg
     6541 gatcacggtc aacgccgtgt gccccggata cgtcgagacg cccatggctg agcagatccg
     6601 gcggcgctac gccgcgcacg agcagaccac ggaggaggcc atcctccagc gtttccaggc
     6661 caagatcccc ctgggccggt attcctcacc ggaggaggtc gcgggcatgg tcggccacct
     6721 gacgaccagg gccgcggact cgatcacctc ccaggccatc aacgtctgcg gcgggctcgg
     6781 caacttctga gccccacacc accgcacagc gaacgaggag gaaggcgaac atgcccttgc
     6841 cacaggagaa cggaacccgc gaggtcgagc acacgagcgt catccaggca ccggccgagg
     6901 atgtgtaccg gctgatcgcc gacgtccagg actggccgct gatcttcccg cccagtgtgc
     6961 acgtcgagca cgagtcacgg agcggccagg aggaggtgat ccgtatctgg gccaccgcga
     7021 acggtctccc caagacgtgg acctcccggc ggcggctgga cccccggggc atgcgcgtcg
     7081 acttccgcca ggtggtctcc agtcctccgg tcgcgagcat gggcggcgcg tggacggtgg
     7141 aggcgctggc cgggggccgc agcctggtcc ggctctcgca cgactaccgc gcgctggacc
     7201 aggcggacct ggactggatc gaccaggccg tggaccgcaa cagcgagtcc gaactcgacg
     7261 ccctcaagcg gagcgcggaa gcgggcctgc gcgggaaccg gacccggctg accttcgagg
     7321 acaccgtacg ggccaaagga cgtgccgagg acctctacgc cttcgtcaac gacgccggcc
     7381 tgtggaggga gcgcctgccc cacgtggctc gggtggtcct caccgaggac accccggggc
     7441 tgcagaccct ggagatggac acccgctccc aggacggctc ggtgcacacc accgagtcgg
     7501 tccgggtctg cttcccgtac gagcggatcg tctacaagca gctccgcgtc ccccctctga
     7561 tgaccctgca caccggtgcg tggagcttca cccaggaggg ggaggaggcc gtggtcacct
     7621 cccgccacac cgtggtgatc aacgaggccc ggatcgggcc gctcctgggt gcggacaaga
     7681 gtctggagga cgcgcgcgat ttcgtccgct cggcgctcgg acgcaacagc ctggccacca
     7741 tgaacctggc caaggaccat gtcgagtccg gtggttgagc ccgtggacgt ggtcgtggtc
     7801 ggagccggac cggtgggcct gatgctcgcc ggcgagctcc ggctcggcgg tgccgacgtg
     7861 gtcgtgctgg aacggctgac ggctcccatc gaggagtccc gggcatccca gctcggaccc
     7921 cggaccgcgg agttgttcct ccagaggggc ctttgggagg cgctcggcga cccgccgcag
     7981 gagaacacgg gtcacttcgg cggcatcccg ctggccgcgg gcggcgccga cggcccggtc
     8041 cccggcaacc ggaaggtgcc gcagcctcga acggaacgga tcctgcacga ctgggcgacc
     8101 gggctgggcg ccaaggtcct acgcgaccac gaggtggtct cggtggaaca gaccgccgac
     8161 gaggccgtgc tgaccgtacg gacccgggga gtgacggcat cctggcgcgc tcgtcacgtg
     8221 gtgggctgcg acggcgccga aagcgtcgtg cgccgcgacg cgggcatccc cttcgacggc
     8281 acgcccgccg aacgggaggt cctgcgcgcc gacctgaagg gcgcgcgcgt gtcgaaccgg
     8341 cgcttcgaac gccttccccg gggagtcgcc gtttcctcga ccagcccgga gggggtcacg
     8401 cgggtcatgg tccacgagta cgaccgcgcc cccgggaccg ccccgccgtc cttcgcggag
     8461 gtcgccgcgg cctgggagcg cgtcaccggt gaggacgtca gcggcgcgac ggccctgtgg
     8521 acggactcct tcgacgacgc ccagggacag gccgccgtct atcgcagggg aagactgttc
     8581 ctcgcggggg acgcggcccg cgtccatgtt ccggccgggg ggcagtcact caacacgggg
     8641 ctgcacgacg cggtcaacct cggctggaag ctggccgcac gggtacacgg ccgggtcggc
     8701 gacgacctcc tggacaccta cgacgccgaa cggcgacggg ccggccagcg cgttctggcc
     8761 aatgtcgcgg tccagaacct cctgctcttc ggagggtccc gctacgaccg catgcgggac
     8821 ctgttcggca acctgctgga gacgcccgtg ttcgcggagt cgctggccga catggtcaac
     8881 ggcgtcggcg agcgttaccc ggctccccac gagaaacccg acgacccgtt gctgggtcga
     8941 cgcctgccgc cctgcccgaa accgcgggga accgccttcc tgccccccga ccggggcgtc
     9001 ctgctcctgg actccgacgg gcccctggcc cgcgcgtcga gggagggggc ggctccctgg
     9061 gtcgaccgtg tggacgtgat cgacgagcgg gacctggtgg gactgctccc ctcacccgtc
     9121 agagcggccc tggtacggcc cgacgggcat gtcgcctgga ccgaccggtg cgaccggtca
     9181 ctgggtgacg cgctccaccg ttggttcggc ccgcccggcc acgcgccgga gggcttgtcg
     9241 gacgttcgag aagggatgtg acgaacggcc atgagcacct cgtccgagtt gtccgccctg
     9301 gctcccgagc ccgttccctc ctggaggcgt gcctccagtg agttgctcag cacccgggag
     9361 cgcctcgcct ccgggccggg ggccaaggcg acacaggccc agcacgacaa ggggaagctg
     9421 accgtccgcg aacgcctgga cgtcctcttc gacgagggca ccttcgtcga ggtggggcca
     9481 ctgcgccgac accgggccac gggtttcggg ttggaggaca agcgccccca caccgacgga
     9541 gtggtcacgg gatggggcac ggtccacggg cgcagggtct tctgctacgc gcacgacttc
     9601 cgcatcttcg gcggcgcgct gggcgaggcg cacgcggcca agatccaccg catcatggac
     9661 ctggcgatcg cggcgggagc accgctggtc agcctgaacg acggagccgg ggcccgtatc
     9721 caggagggcg tcaccgccct ggccggatac ggggggatct tccagcgcaa cacccgcgcc
     9781 tccgggatga tcccgcagat cagcgtcatg ctcggcccct gcgcgggcgg cgccgcctac
     9841 tcacccgcgc tgaccgactt cgtcttcatg gtccggggga tctcccagat gttcatcacc
     9901 ggaccggacg tggtgcggtc ggtgaccggg gaggaggtca cacacgacgg tctgggcgga
     9961 gccgacgtgc acgccgccgt ctccggcgtc tgccacgtca tccacgacga cgagcacgca
    10021 tgtctggagg acgtgcgcta cctgctctcg ctgctgcccc agaacaacag ggagtccgca
    10081 ccgcgggagc cgtgcgacga cccggtcgac cgccgttcca cacgcctgct ggacctcgtg
    10141 ccgcccgatg gcggacgttc ctacgacatg cgccgggtga tcggcgagat cgtcgacgac
    10201 ggcgagttca tggagatcca ggagggctgg gcgcggaaca tcgtgtgcgt gctggcccgc
    10261 ctcgacggac acgtcgtggg catcgtggcc aaccagccga gtgtcatggc gggggtgctc
    10321 gacatcgacg cctccaagaa gggcgccggg ttcgtgcaga cgtgcgactc cttcaacatc
    10381 cccctggtct ccctggtcga cgtccccggc ttcctgcccg gagtcgagca ggagcaccag
    10441 gggatcatcc ggcacggcgc acaactgctg tacgcctact gcaacgccac cgtgccccgg
    10501 gtctccgtga tcctgcgcaa ggcctacgga ggcgcctaca tcgtcatgga ctcccagtcc
    10561 gtgggcgccg acctgaccta cgcgtggccg ctgaacgaga tcgcggtgat gggggccggc
    10621 gccgccgccg acgtgatctt ccgtcggcgc atcgccgagg ccgacgaccc cggggccctc
    10681 cgggaactgc tgatcaagga atacgagtcc gagctgatgc acccctacca cgcggcggag
    10741 cacgggctcg tcgacgacgt catcccgccc gacgagaccc gcgaggtcct ggtgcgggcg
    10801 ttgcgtgccc tgcgcgccaa gcacgccgac cttccctccc gcaaacacgg caaccccccg
    10861 atgtgaagga gacccaccag catgaaccgg atcccgggcg cacccgatcc ctgtctgagg
    10921 atcgtgcggg gaaggccgtc cgtcgaggag accgccgcgc tggtcgcggt gagcatgctc
    10981 ctggagagga acgcgtcccg ccggtcagag gaggcgcctc ccggtcccgt gccgtggaac
    11041 aggccccggg acctgtcagc gctcagttgg caggcacgat gagatcgccc ctgtacgtcg
    11101 cctcctgcgc gctccacctg cccacggtgg tgtccgccgc cgaggaactg gccgccggcc
    11161 actgcgaaca ggagaccgtc accgccacgg gagcgacggg ggtcgccgtc gcgcacgagg
    11221 agtcggcgcc ccggatggcg gtgcgggccg cctccctggc catggaacgc ggaggccgtg
    11281 agccggccga catctccctc ctgctgcacg ccagtgtctt cttccaggga cacgaggtgt
    11341 gggcacccgc ctcctacata cgccatgagg ccctcggcgt gggcgggcag tcgatcgacg
    11401 tctcccaggc ctccaacggc gcgatggcgg cgatcgacct ggccgccgct tacctggcgg
    11461 ctgatccggc gtgcggggaa gcactcgtca ccaccggtga ccgctgcccc tctccgggct
    11521 tcgaccgctg gcgcagcgac cccggcaccg tctacggcga cggcggtacc gcgctcgtgc
    11581 tctcccggac agacggcttc gcccgcctac gctccctggt gacggtcagt gatccgggcc
    11641 tggagcgcat ccaccggggg gacgctccct tcaccagcgc accgttcacc caccgctcca
    11701 ccgtcgacct ggaagccgcc aagcgtgagt acatcgcggc cgagggcctg tcccccacgg
    11761 tcgcgcgggt caacgcgggg cagaacggcg cggtcaaaca cgctctggcc gaggccgatg
    11821 tggaactcgg tgacatctcc cgggtggtac tgccgcacct gggtctcaaa cggctgcggg
    11881 cgggattcct gcgccgtttg gacctggatc cgcagatcac cacctggccc tggagccgcg
    11941 gggtgggcca cctcagcgcg ggtgacccga tcgccggcct ggaccacctg gtgggcacgg
    12001 gagcgctcgg gccgggtgac ctgtgtctgc tcgtgagtgt cggcgccgga ttcacctggt
    12061 cgtgcgccgt ggtggagatg ttgcacagcc ctggttgggc gtccggctca ggaaacggag
    12121 aatgaccatg accgccgcgg aaacccgcac agagagggcc ctcccgtccc cggtcgccct
    12181 gctgcttccc ggacagggcg cccagcacgt gaggatggcc gcagggcttc acggagaggt
    12241 cccgaccttc accgaggccg tggaggaggt tttcgcggcg atgggccgcg agggccgggc
    12301 tctgcgctcg gactggctgt ccgcacggcc ccgtgtccac atcgaccacg ccacacgggc
    12361 ccagccgctc ctgttcgccg tggactacgg cctctgccgc ctgctgctgg gccagggtgt
    12421 gcggcccgcg gccctgctgg ggcacagcat gggtgaggtg gtggcggccg tcgtcgccgg
    12481 ggtcttctcc ctggaggacg cctgcgcgct cgccctggac cgcgtggagc gggtgctgcg
    12541 ggctccggcc ggaggtatgg ccgcggtctc ggcgacaccg cgggagctgg agccccatct
    12601 gcactcgggt gtggccgtgg gcggggtcaa cgcgccgaga cagaccgtcc tggccggacc
    12661 cgagaccggt ctggacaccg tcctgggcca gctccgcgag cgagggttca gcctgcgccg
    12721 catcccgtca ctgaccgggt tccacagtcc gctcctggac gaggtgctca agggctcgga
    12781 agacctgttc gagggcgtgc ggacacgcgc gcccgagatc cccgtctact ccggttacac
    12841 ggcggccctc ctgacggctg accaggcggg cgacccgtcg ttctgggcgg ggcagccggc
    12901 cgcgccggtg atgttctggc cggctctgga aagactgctc gccgacggcc ccttcaccct
    12961 ggtcgaggcc ggaccgggtc agggcctctc ccagctcgcc aggaggcatc cggcggtacg
    13021 ggccgggcac agtgccgtcc tgtccatgct tccggcccgc cctggaacgg ccgaggacga
    13081 cctgcgttcg gtgcgcacca cgctggagaa gctgcggaac cgggaggcgc cgtgagggcg
    13141 cggacggcac ggtgcgctcc tcagccggag cgcacctcct tcgcccaggc ctccaggccg
    13201 gcggcgaaac cctgcgaatc ccggggatcc aggtgctcga acacgcgcag gagcggagcg
    13261 gctcgcttgg cgatgaacac ccgcatcgtc tcccgatggt cctcggccag ggccaccagc
    13321 acacgccgac ggttggcggg gtccttgcgc ctgacgacca gccccgccca ctccaggtcc
    13381 cccaccagct cactgacggt ggacagcccg acgctcaacc gagcggacag ctcgcccaca
    13441 ccgagttccg gttcgtgtgc gagctgtacg agcacaccgc cgtgacggcc ggtgaggcgg
    13501 tagcggtcga agaggtcctg gaggtccttg ggcatctccg tgtgggcgcg gcggtagtag
    13561 acctccagca tggggacgaa gcgcagcgct cccttgacga gatcgaggtc caacgcctgg
    13621 gcttcgccca cgctttcctc ctggctcatg ggtggatggt atcccaaacg ctcccagaac
    13681 ctccccgtac ccggaccgta gtgaacagcc agatcaacac ggcaacgaag gagaccacag
    13741 gatgagcgac acagagatca ccgaggtcag cgcctcagtc ctcaccggcc tgtcggggct
    13801 gccctcccgg ctcgtggaca cggtgaaccg ctccgagatc gaggacctca tctcacggca
    13861 ctacctgtcg cccgacgagc ggcgtgtcga cgacgggtgg ctgacctccg tgtacaccga
    13921 ggacttcgtc atcgtcctcc cccacggcac ctatgagggc tacgacggga tgcgtgaggc
    13981 cctggagaac gcgtcctcga tcttcgaggc cagccaccat ctggtgtcca accacgtgat
    14041 cgacctgaag ggcggttccg cgtcgatccg ttccgtgctc atcgctaccc acctggccga
    14101 cgccgaggcc cccgcgcagg cctacaccac cggcgccatc taccggttcg aggccctgta
    14161 caccgctgac ggctggcggc tggcccgggc cgagttcgac ggtgtgtgga ccgcgggtga
    14221 accgcccttc gagaccacga acccctgagc ccggtgccgc ccgtcctgtt ccgcccgggg
    14281 cgggcggccc gcctcccgcc ccggaagccc tgttcacgag gaaggtgaag agccgtgatg
    14341 acgttccgtg tcctcggcat gctggaggtc gggttggacg accggacgta ctcacccacc
    14401 ggtggcaaga ttcgccagct cctcgccctg ttcctgtgcc gggccaacga ggtggtcagc
    14461 ccggaggcgc tcatggagga gctgtggggg gacgcgcccc ctcgaagcgc gatggtgacc
    14521 ttgcagtcac acgtgtacca actgcgcaga gccctggaca gggccttccc cgaagccggg
    14581 ttgggcaggg ctctggtcac ccgttcccgg gggtacatgt tctccgtccc cgaagggcgg
    14641 gtcgacgcgt tggagttcga gcggctcgtc ctccaggcac gacgcctggc ggagcggggc
    14701 cggccgaccg aggccctgga ggcgtcgcgc gccgcgcgga acctgtggcg gggcgaggta
    14761 ctgagcgacg tccagcgcgg tcccctgctg aacgcgcacg ccgttcgcct ggctgaactc
    14821 cggctcaccg cgatacgagc gtgcgtggcg gccgacatgg acctgttccg ctacggcgag
    14881 ctggttccgc agctgcgcac gctggtggcc tactacccgt tcgacgagtg gttccacgtc
    14941 cagctcatca gggcgctggc cggggacggc agacgcgggg acgcgttact cagctacgac
    15001 cacgtgtgcc gcctgctcga cgaagaactc ggcctggagc cttcggccga actcagaagg
    15061 ctccgggccg agatcctctc gggcgatgtg cggcggttca ggggacgacc agctcgggac
    15121 ggctcggaga ggtcaccgtc tccggacgga gtccacgcat catgacccgg gtgatgatgc
    15181 gcgagtagag ccaggtggcc gccttcgagc ccgtctctga ggagagcacg gccctggtca
    15241 gcgaagaatc cggcgcggag gagcccggcg cggaggcgtc gggttcgctc tcgggacggg
    15301 ggatcacctg tccgaagagt tcgcgctgga tgaactgctg gaccctctgg gtcccggtgt
    15361 cggggaacca ccggcgtctt tgcacccgtg cgaggaattc ggggttgaac gtgcgctcga
    15421 aacggtcggg gtggcgctgt gcgcgcgaca ggggaccggc cagtatgttg gcggccgcca
    15481 ccgcgtcctg gaccgccagg ttgatcccca caccgccgac cggggtcatg gcgtgcgcgg
    15541 cgtccccgat acacaggtaa ccgggggtgt accagcgctc cagccggtcc agcccgacgt
    15601 tgagcagggc caccttctcc cagtccgaaa cctcgctgac ccggtcgccc aggaagggca
    15661 gcagctcgcg cagccgctcc tggaggcgtt cgaccggttc gcggcgcagt gcgtcgaacc
    15721 cgcccttacg gatgacgtaa gcgatctgcc agtagtctcc gcggtcgatg gcgaacgcca
    15781 tggtgccctc accggtgcgt ccgttgaggc cctcgacctg ctcggaggca cgggagaccc
    15841 gcagccacag gacgtccatc ggcgatccga gccggcgggg acgcaggccg gcgaactcgc
    15901 gcagccgcga gttgcgtccg tcggccgaga cggtgagcac cgaccgcagc cgatgggttc
    15961 cctcggggtc ggtgtactcc accccgcgca cggcgtcgcc cttccgcagc agaagggtgc
    16021 tggtggcgtt catgagcagg cggaagttgg gatagcggcg tgcctcacgg gccagcatgt
    16081 caaggaagtc ccactgcggg atcatcgaga tgtaggggtg cgacccggga acggatccga
    16141 gatcggcctc gatggtgccg gcgtgctcgc tgcccacagt gaccttccgg accttgcggt
    16201 gcggtatccg gttcacctcc tcaccgaggc cgatgtcctc cagcacctgg agggtggagg
    16261 ggtgaacggt gtcaccacgg aagtcgttga agaagtccgc gtgcttctcc agcacggtga
    16321 cgtccacgcc cgcacgggcc agcaggagcc cgagcatcat gcccgcggga ccccctcctg
    16381 acaccgcgac ggtcgtctca cctctggatg tcctgggctg tgaggggttg gagaggggca
    16441 tctggtcagc cttccgtctt ggggtgccgt cctgccgagg cgccgtcgaa ctccctcagc
    16501 gggagacgcc gaccgcctgc ttgagtgtcg ccgggtcctc cagcgcggcc agtgccgcgt
    16561 gggccaggtc cgcccgtgag atcgagagcc cgcctgagac gttcgtaccg agggacatgc
    16621 ggtgcagacc ggtgagtggt ccgtcagtca ggcgcggcgg cctcaggatg gtccagtcgg
    16681 tgtcgctggc ggacagggac cgctccatca ccgccaggtc gcggtaggcg tcccggaaca
    16741 cccagcccac cagtggtgtg accaccttct tgatgaccat ggactcccgg gcggggggcg
    16801 gcccgagcgg ggaggcgctc accgcgacca gccgtggtcg gggatgatcc tccaccgccc
    16861 gcaggatggc gctgatccac gtggacgcgg ggaacccgcc gcgggcgctg gctcccaacg
    16921 cggagatgac ggcgtcgccg tgggcgagcg tctgagccag cctccccagg tcgggtgtgt
    16981 ccatacggac ggtctccagg cgcacgtggc tgaggggaag gcggccgggg tcgcggacga
    17041 ccgcctgcac ccggtgtccc gctcgcaggg cctgtgccac gacatgccgt ccggtgcctc
    17101 cggtggcacc gaacacggtc acgtgcaggg ttcgcctcat cgtttcctcc ctcacctccc
    17161 gaggtgcggt cagaccggtc ggcagaggat cggcagggcc accatgccgt tggccttgat
    17221 ctgtttgcgt acgaaccggt ggaagctcgg ccgggtgagc tggttgacca tgaagggcac
    17281 cgctccgccg ggaagccgtg cgtagttgac gaaggcgaaa cgcccgtcgt ctaccgacct
    17341 cagcggggcg gagttgtcga taccggtctt ggcggtgtac cagccggtca gcccctccca
    17401 gacgccgatc cccgcttcct tgtcccgggc ggtgaagtgg ttgaacaggt agacacccgt
    17461 ggcagggctc tccggatcgc cgatacgcgc ggggttgtcg gcggacatga ccaggtccgc
    17521 gcccaactgg tcgaaccgcg cggaagcgat gacgtcgtcg ttgtgcccgg gggaggcggt
    17581 ctccacgagc atcatcacgt cgaagcgggg cgatcccttc agcggcggta tgagcaccgc
    17641 ttcgaagacc ctcgtccgga cgacgtcgtc gcgggttgac agccgccggg ccgtggacag
    17701 gcactcctcg atcgcgtcgt cgcgctcgga gctgctccgg accaggggcg cgtgcggcgg
    17761 gtccaccgac aacccgacgt agacgaaccc cgaggtcgag ggggatcgga acttcggttt
    17821 cgggtacctg gcgcttgccg tggacatggt caacgtcctc tcctgacttc tccttggaca
    17881 ccatagttcg acttcccgaa ctatacacaa tgaaaacgaa ggtccacttc cacccgcatt
    17941 ccacggcttc tccaaccact ttccaggggc ctggacaaag ctggggaaag catcagccaa
    18001 aagcccagga agggacgcac gatgaacgac gctccccgtg aggacaccgt ctatgacgcc
    18061 gtcatcgtcg gcggcggacc cggaggcgcg gcctgcgcga tgaccctggc acgggcgggt
    18121 cggtccgttc tgcttctgga gaggaccgtc ttcccccggt tccacatcgg agagtccctg
    18181 ctcacctaca cagtcgacgt gttggcacgc ctcggtgtac tggaccgcgt cctggcgagc
    18241 gggttcgtcg tcaaacgggg cgtggagctg agcgggcccg agggcaactc ctaccgcatc
    18301 ggcttcgacg agatcggcga gggctaccgc gactggaccc tgcaggtgga acgggccgag
    18361 ttcgaccaga tcctcctcga cgccgcggcg gccgagggcg ccaaggtggt ggagggcgcc
    18421 cgggtcaccg ccccggtgct ctccggagac cgtgtgagcg gggtccgcta cacccttgac
    18481 gacggctcca gctccaccgt gcgcgcccac tacgtcgtgg acgccagcgg acggaccgga
    18541 gtgatctcac gcgcgctggg gctgcgcagg aacgacgaga gcatccgcat ggtggcggcg
    18601 ttcaagcact acgccggaac ccacgaactc cacaacccgg gggccaaggg cgacatccag
    18661 ctcggcaacc acccggacgg ctgggtctgg ggcatcccga tccgcaagga cgtcatcagc
    18721 atcggcacgg tggtccccgt ggacgtcatg cgccagggca gggccgagga ggtcttcgag
    18781 gagcacctgt cccgcattcc gcgtatccac gcgcgcaccc ggggcgcccg ggtggtcagg
    18841 gaactcaccg gggagaccga ctacagccac tactccgagc ggttggccgg ccccggctac
    18901 tacatcgtcg gcgacgcggg ttgcttcacc gacccgatct tctccgcggg ggtcttcctc
    18961 gccctggtca ccggtatgga gtcagccgcc tgtgtcaacg cctccctgga cggggcgggc
    19021 cccgggcgcg agcgcgaaat cgccacctcc tacgaggact tctgcaagac cggtttcgac
    19081 acctaccacc ggctgatccg ggccttctac gacaacggct acagcgtcta ccgctatctc
    19141 accggagcga tcgacgaccc cacccagctc ggaggcatcc tgcgcctcct caacggtgac
    19201 ttctggaacg agcacgatcc cgtctcccgc aagctccgcg aggtccccca gtgggggatg
    19261 ttcgagagtt tcacccccga ctacaactgt ccggtccacg gagaccgctg acccttggga
    19321 ggttcccgtg gaatcgatcc ccacactgac cgcccacgtc ttcgccgccc tggccgccat
    19381 cgtcctcgtg gcatcggtgt tcgggcggat cgcggtcctc ctcagacagc cgcgcgtcgt
    19441 gggcgagatg gtcgccggcg tcctgatggg accgtccctg ctgggatggt tgctgcccga
    19501 cgtgcaggag gccctgttcc ccgccgaggt ccgtcccgcc ctgtacctgc tcagcatgat
    19561 cgggctggtg ttcttcatgt tcctggtcgg cgcgggcatc cggcacggcg tcctcgaccg
    19621 ccgctccacc cgtggagcgc tgtcggtggg cgtggtcgga gtggtggtcc ccctcgccct
    19681 gggcgtcacc gtcgcctggg ccctcgccga ccagatctcc gaccccggga cgccgcgcct
    19741 gcaggtgtcc ctgctcctgg gcggcgcgct caccgtcacg gccttcccga tgctcgcgcg
    19801 gatcctgaac gaacgaggca tgcagtcctc acgccttggc gcggtgaccc tgctggccgc
    19861 gtcggtggac gacgccgccg cctggatcgt cctggcggtc atactcgcgc tcgccttcgg
    19921 cggctccatg gccggtgtgg cggcctcgct ggtgggtgtc gcggtcttca cggtggtgat
    19981 gctcaagctc gcgccgcgcc tgctggcacc gatcgcccgg tcggtggagc ggaacggaca
    20041 tctcactccc ggggcactcg ccgtggtggt cctgctgatc ctcggcgcgg cctggacgac
    20101 ccacgaactg ggaatccact tcgtcttcgg cggattcatc gtcggcatca gcctgccggc
    20161 ctctcccgcg ctgcgcgagt gcgtacggaa ccggttgatg gacatgaacg tcggtctgct
    20221 gctgccggtg ttcttcatct acaccggact caacaccgac ctgggcgggc tggtcagcgg
    20281 cagcgcgctg ctggccgtca tcgccatcac cgccgtggcc ttcatcggca agtacctgtc
    20341 ctgcctgttc gtgatgcgtg ccctgggtca ttcctggcgg gtcgcctccg ccgcgggcgg
    20401 gctgatgaac gcgcgtggcc tgatggtcct catcttcatc aacatcgggc ttgagcacgg
    20461 ggtgttgtca caggacctgt tctcgatcct cgtcctcgtc gccgtggtga ccacggtcgc
    20521 cgcactgccc atctaccggc tctccctgcc cgactcgctg gaggccgccg agcgcctcga
    20581 cacggccgac cccgaccccg aacccgaacc cgcgacgccg ccgcgcgagg cacgggagaa
    20641 ggaggccgag acagcgatgg ccaacgaacc atgatcggtc gcgtccccag gaacgggtga
    20701 cctcgtaccg caccgcgttc tccccgggcc acaagcccgc ggggggatca gaggggtggg
    20761 ccggaacacg gcccgcccca tcactccgcg gggcgccgga gaccgcacca ccgacctggg
    20821 gcatcggccg gaagcggcgc cggtggagag cgtcgacctc ccccgtacgg cgcccgcgcg
    20881 gaagccgctt ggcgtcctcg cgcgcggagg ccatccgggc acggcacacg ggaggagcac
    20941 cgggtgcgcc tcctccccct accgctcacc cgaccctctc gcggacgcgg tcggcgaggt
    21001 ccccgtcgcg tgcgatccgg gcgagcccgg ccgccaggtg cgcgatgtcg tcgccctcca
    21061 cgactctggc gagcttgtcc ccgtcctccg gcaggccgac cttcctggct ccgcccagca
    21121 cgtacttgtc ggtgtagggc cgcagccagg gccacaccgc ctggacctcc cggcagaaca
    21181 tcacggcgcc cgtcggcccg atcccggaga actcctggac catcgactcc acccggctcg
    21241 cccggtgacc ggagcgctcc ccgagtctgc gcaggtcgcc ctggtactcc tcgcgcaccc
    21301 ggtcgacgca ctcgccgagc cgggtggcgg tgctctcgtc gtagcgcacg tagtgcccgc
    21361 gccccagcgc gtccacgcgg tcctgccagc tgagcgaggc catcccgtcg ggggtcgtgc
    21421 cgcccgcctc gttgagctcc ctggcggcgg cgatcgcgat ccgcgccgag atgcgcgcgg
    21481 acagcaggtt caccagcacc agcagctgcc acagcgcgga gggtctgtcc gccatccgga
    21541 tcccggcctc ggcggcgagg gtcgtccccg cctcgtccac cacggcgcgg gcgacgtcgg
    21601 cgttcctggc catctcccgg tccccttcca ggtgtggtcg gatgcgtcct ggtacggggc
    21661 tgatacccgg tcagggggcg ctgacgcgat atccacaggg ccgtgtacga ctccccgcac
    21721 cgacaccgac ggccggaaac acctctccgg accgccccgg gcccgtgggg acgcccctcc
    21781 cgcggcccgg tccgccgggg tccgggagcg ggggccgcct cccccggccg gcgccggaca
    21841 cgggagagcc ccggaaccgg gtcccgtccc ggttccgggg ctcctccccg ccgcggtgcc
    21901 cggctccggg ctcaggcgtg gctcagtccg ttgcggtggg gcggcgcgtc gctgtgctgg
    21961 ccgacgctgg ccgggatcgt gtggcgcgcc ttccccttgt cgatgccgag gaagcggttg
    22021 aggtggccct tgcggcccac cacgaaccag gcgatcgccc cgaacaacgg gaaccagagg
    22081 atgaagatga cccacagcag cttgccgccc gcggaggtgt cgcggtcgac cagcgccgag
    22141 atgaccgcgg cgaggagcag gaccagcagc gccagtccca cgagcgccag gatcaccccg
    22201 aaggtcccgc tcatccaggt gacggccgtg tccgcgcggt ccgcgaggtt cgtgatcatg
    22261 gtttccccca acaaggcaca ctccctattg ttacgcagag taactggttg tgcgggggat
    22321 cccgtggcgt ttcccggttt cgggcgtttc cactacgcaa ggacggggtt ccgattccac
    22381 ggtgactttc cgaactcggg tcactacttt caggtaagcc cacctgtcgg gcccctgcgc
    22441 tgctttactg ggaaccatgg gcgagcttcg gcgatctggc aggttcactc ccctcctccc
    22501 ccccggattc cccaccggag acggtggcgg ccccggcacc ggcgaccacc gcgtccccgt
    22561 tcccccggcg gagcgcagag accaacgggc gacgggaggc cgcgcggccg aggccccgta
    22621 accgtgggca ggcaacccag gtacctctgg ctggccgaac agctgcgcgg accgatcctg
    22681 agcggggagc tgccgcccgg cacgcgtctg ccctcccgga cccggctggc gcgctcctac
    22741 cgcgtcagcg agcagatctc ccgcaccgcg ctccggctcc tggtcaccga gggcctggtc
    22801 gagtccaggc cgggctccgg gtactacgtg cgcaccgtcc ccgagctctt ccgcatctgc
    22861 cggaccgact cctcctccgg ctccggcctg gggcggctca gccgcgaggc gatcggcacc
    22921 gagcaggagc agtgcgcgcc gccgctgagc ctccggttgc ggctgcgcga gggagaaccg
    22981 gtgtaccgca ccacctcgcg cgggctgtcc tcggagctgc ccatcaccct gcaccggtcc
    23041 tgggagcccg cgtccctgac cgcgggcacc ctgcgcaccc ccttcgacag ctcgcccggc
    23101 agcggactgc tcgaacggct cagcgcggcg ggccaccccg tcgaccgcgt ggtggaggag
    23161 gtgggcgtac gcgccctgcg cgactccgag gcctccctgc tcggatcggc gccggggata
    23221 cccgtgctgg tggtggagcg cacccacttc agcggcaacc ggccggtgga gacctccgac
    23281 ctcatcggct cgtccgagca gtgtcgactc ctctacaaac tgacactggc ccggccccgc
    23341 cgccccggcg acccgcggcg gtactgaccc gggcacacgc ggggccggca ccctccggga
    23401 cgggcacccg gacacccggg cgccgacccc ggacacgcgt gagggcggcg gctccctccc
    23461 ggaggagggg gccgccgccc tcaccgttca ccgaacacca cgccggtgcg gacatcgccg
    23521 gacgtctgct ccgcccaacc gttccccgtc acccggagtg accggctgga gtcgcccgac
    23581 ggtgtgcgcg gtcaggcccg ggtgaactcc ccggccacga cctcggcgat ctgcgccgtg
    23641 ttgagcgcgg cgcccttgcg caggttgtcc ccgcacagga acaggtccag cgacctcggg
    23701 tcgtccagcg actggcggat gcggccgacc caggtcgggt cggtgcccac gacgtcggcc
    23761 ggggtcggga actcgccgtt ggccgggtcg tcctggacct ggacgccctc cgcggagccg
    23821 agcagctcac gggcggcgtc ggcgggcacc tcctcggcga aggacgcgtg cacgaccagc
    23881 gagtgggtgg tgatcacggg gacgcggaca caggtggccg agacgcgcag gtcgggcagc
    23941 cccaggatct tgcgggactc gttgcggacc ttgagctcct ccgaggacca gccgccgtcc
    24001 ttgagcgaac ccgcccacgg aacgacgttg taggccagcg gcgccgggaa cggacccagc
    24061 tcgccgacgg cggcgcgcac gtcgcccgcc gtgtcgccca ggctgcggtc ggcgccggcc
    24121 ttggccatct ggtcgcgcag ggtgtcgatg ccctcctggc cggcgccgga ggcggcctgg
    24181 taggaggaga ccaccaggtc ggtgacgccg taggcgcggt gcagggcacc gatggccacg
    24241 atcatcgaca gggtggtgca gttggggttg ctgatgatgc cgcgcggacg gttgcggacc
    24301 tggtccgcgt tgacctcggg caccacgagc gggacgtcgg ggtccatgcg gaacgcgccg
    24361 gagttgtcga cggcgaccgc gccgcgggag gcggcgaccg gagcccactc cttggacacc
    24421 tcgtcgggga cgtcgaacat ggcgacgtcc acgccgtcga agacctcggg ggccagggcc
    24481 tggaccacga cgtcctcgcc gcgcacgcgc aggaccttgc ccgcgctgcg cggggaggcg
    24541 acgaggcgga tctcgcccca gacgttctcg cgctgggtca ggatgtccag catcacggtg
    24601 ccgacggcgc cggtggcgcc gacgacggcg agggtgggaa gacggttgct catcggccgg
    24661 tacctccgta cacgacagcc tcgacctggt cggcgtcgag ctggaactca ctgtgggcgg
    24721 cgcggacggc cgcgtcgatc tggtcctcct cgacgatcac cgagatgcgg atctccgagg
    24781 tggagatcat ctcgacgttg gtgctcgaac cggcgatggc gtcgaagaag cgggcggtga
    24841 cgcccgggta ggagcgcatg cccgcgccga tcagcgacac cttgccgatc ttgtcgtcgt
    24901 agcgcaggga ctcgaacccg accttgtcct gcaccttctt gagcgcggcg acggcctcct
    24961 tgccgaagtc cttggggacc gtgaaggaga tgtcggtgcg cgaggtggag accgccgaca
    25021 cgttctggac gatcatgtcg atgttgatct cggcgtcggc cagggcccgg aagatcgtcg
    25081 cggcctcacc gatcttgtcg ggcacgccga cgacggtgat cttggcttcg ctccggtcgt
    25141 gagagacacc ggagatgatc ggctgttcca tgccttcgct ttcctcgact tccgggacga
    25201 cccaggtccc tggcttctgg ctgaaagatg aacggacgtg aagggggatg ttgtactgac
    25261 gcgcgtactc gacacagcgc aggtgcagga tcttggtccc ggacgccgcc atctccagca
    25321 tctcctcgta ggagacctgg gggatgcgct gggcggtcgg cacgatacgc gggtcggcgg
    25381 tgaacacacc gtcgacgtcg ctgtagatct cgcaggcgtc ggcctccagg gcggcggcca
    25441 gcgcgacggc ggtggtgtcg gagccgcccc ggcccaggga cgtgatgtcc ttggtgtcct
    25501 gggagacgcc ctggaacccg gcgacgatgc agatcgcgcc ctcgcccacg gcctcctgga
    25561 tccgacccgg cgtcacgtcg atgatcttgg cgttgccgtg cagcgacgtg gtgatcacac
    25621 cggcctggga accggtgaag gacctggcct cgaaccccag gttctcgatg gccatcgcca
    25681 cgagtgccat ggacatgcgc tcacccgcgg tgaccagcat gtccagttcg cgcgctggcg
    25741 gcatcgggct gacctgctcg gccaggtcca ggagttcgtc ggtggtgtcg cccatggccg
    25801 agaccacgac gacgacgtca tatcccgcct ttttctgagc gacgatccgc tgggctactc
    25861 gcttgatggc ttccgcgtct gccacggaag acccaccgta cttctgcacg attagggcca
    25921 cgatcgatgc tcctgaggag ttgggatcaa gacaatgaaa tggagtgtag ccacagacgt
    25981 cctcgtccac cccatctgac
//
