BGC0002504 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002504 (Nocardiopsis sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T2PKS	1	26,000	nocardiopsistin A/nocardiopsistin B/nocardiopsistin C	PKS	100%

BGC0002504 - Region 1 - PKS-like,T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 26,000 nt. (total: 26,000 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 26,001
Label		BGC0002504

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002504	2.00	Polyketide	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.
BGC0000231	1.10	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001723	0.77	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234	0.70	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002608	0.65	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0002047	0.58	Polyketide	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000	0.53	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002443	0.52	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0002477	0.52	Polyketide	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0001366	0.51	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002504	1.00	Polyketide	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.
BGC0000231	0.81	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001723	0.71	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234	0.68	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002608	0.66	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0002047	0.63	Polyketide	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000	0.60	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002443	0.59	Polyketide	mycemycin C, mycemycin A, mycemycin B	Streptomyces olivaceus
BGC0002477	0.59	Polyketide	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0001366	0.59	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

QOP59278.1

PKS_AT (21..303): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 52.0
Methylmalonyl-CoA: 31.9
Methoxymalonyl-CoA: 28.4
inactive: 14.8
fatty_acid: 10.5
Propionyl-CoA: 9.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 26000
Starter unit(s):: propionyl-CoA (Score: 745.0; E-value: 9.75e-137)
Malonyl elongations:: 8|9 (Score: 657.2; E-value: 1.8e-200)
Product class(es):: angucycline
Product molecular weight(s):: propionyl-CoA_8: 411 Da
propionyl-CoA_9: 453 Da

QOP59268.1: OXY (Score: 569.8; E-value: 1.1e-173)
QOP59269.1: CYC C4-C17/C2-C19 (Score: 163.4; E-value: 1.3e-50)
QOP59270.1: KS (Score: 764.0; E-value: 8.4e-233)
QOP59271.1: CLF 8|9 (Score: 657.2; E-value: 1.8e-200)
QOP59272.1: ACP (Score: 102.5; E-value: 2.2e-32)
QOP59273.1: KR C9 (Score: 465.9; E-value: 7.7e-143)
QOP59274.1: CYC C7-C12 (Score: 448.4; E-value: 2.4e-137)
QOP59275.1: OXY (Score: 474.4; E-value: 1e-144)
QOP59277.1: KSIII (Score: 448.9; E-value: 2.5e-137); KSIII ABC00733.1_Cosmomycin_propionyl-CoA (Score: 383.0; E-value: 9.75e-137)
QOP59278.1: AT (Score: 417.7; E-value: 7.8e-128); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 362.0; E-value: 3.87e-128)
QOP59281.1: OXY (Score: 103.3; E-value: 3.6e-32)
QOP59283.1: OXY (Score: 55.5; E-value: 1.2e-17)