LOCUS       BGC0002506             23837 bp    DNA     linear   BCT 25-OCT-2020
DEFINITION  Streptomyces sp. FXJ8.102 piloquinone gene cluster, complete
            sequence.
ACCESSION   BGC0002506
VERSION     BGC0002506
KEYWORDS    .
SOURCE      Streptomyces sp. FXJ8.102
  ORGANISM  Streptomyces sp. FXJ8.102
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 23837)
  AUTHORS   Zhang,Q., Ren,J., Wang,W., Zhai,J., Yang,J., Liu,N., Huang,Y.,
            Pan,G., Chen,Y. and Fan,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUL-2019) State Key Laboratory of Microbial Resources,
            Institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Chaoyang District, Beijing, Beijing 100101, China
COMMENT     ##antiSMASH-Data-START##
            Version     :: False
            Run date    :: 2025-08-15 21:59:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start :: 0
            Orig. end   :: 23837
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..23837
                     /country="China"
                     /db_xref="taxon:1581323"
                     /isolation_source="deep-sea strain isolated from the
                     Southwest Indian Ridge"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. FXJ8.102"
                     /strain="FXJ8.102"
     misc_feature    1..23837
                     /note="piloquinone gene cluster"
     region          1..23837
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..23837
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..23837
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23837
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11211:13633](+)"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11212..13633
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
     gene            385..1284
                     /gene="plqR1"
     CDS             385..1284
                     /codon_start=1
                     /gene="plqR1"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /product="SARP family regulator"
                     /protein_id="QFS19033.1"
                     /transl_table=11
                     /translation="MEFSVLGPLRMYEGGKSYTPTAPKQRQLLTLLLLNANQVVSTDTC
                     IEELWENSPPNSALSTLQSYILQLRRSLRRVPRIGSLQAARLILETRDGGYLLAVRSDE
                     LDTNRFWSLVREGRSALHHDDVRASACLSEALRLWQGSALSDVQRGPVLRALLVGLEEE
                     RTSVQEQRIAADLRLGRHQELLGELSRLTAKYPMHEGLHAQFMLALHRTGRRTQALEVL
                     RRLGTVLRDELGLDPSPRVRRLHQAILAGDPALDVPARTDSVLTAEPGAPIGRRLPAGG
                     DLVAVGAAAGRPEQLVRR"
     gene            complement(1399..2046)
                     /gene="plqR2"
     CDS             complement(1399..2046)
                     /codon_start=1
                     /gene="plqR2"
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /product="TetR family regulator"
                     /protein_id="QFS19034.1"
                     /transl_table=11
                     /translation="MSTPADATGHIPPAPERGMDPRAARSRAAALAAAQELLVEQGWSA
                     VTHVAVAARSGVGRTTLYRHWPDSPSLIYEAIAQRIASARPTRSGVLRDDLIGQLNGLR
                     ALLHDPVGERGMRVVVERAGVDPAFAGLKEALYQAGSGGFRAIIEGAKESGELPGGLDT
                     ELAIDQLAGPLMFRRLLAERTFGAEYVRTVVDGFLAANASSRPGAAVGDGER"
     gene            complement(2151..3020)
                     /gene="plqV"
     CDS             complement(2151..3020)
                     /codon_start=1
                     /gene="plqV"
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="QFS19035.1"
                     /transl_table=11
                     /translation="MILVTGATGNVGGKVLSLLRAGGHKVRALTRDPQRVAFPEGADLE
                     VVAADLGRPGTLAPALDGVQKVFLMSLGANKATHDAHMVAAARAAGVEHIVQLSTLGVE
                     VAEDARANPLGHWHRIAEEALRDSGLPWTILRPNGFMSMNLGWAASIKAEGVARGPLAD
                     VPEAIVDPRDIAEVAARALTEDGHEGRIHELTGPQALTGREQLAVLAGLLGRDLRFETV
                     PLAAHRETMLRHFSEETVNGVIRTLEEAIEHGSELHGRLSPDVRRVLGREPRSFAEWAR
                     DHLDLYRS"
     gene            complement(3074..4702)
                     /gene="plqU"
     CDS             complement(3074..4702)
                     /codon_start=1
                     /gene="plqU"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="FAD dependent monooxygenase"
                     /protein_id="QFS19036.1"
                     /transl_table=11
                     /translation="MSDEHVPVLIVGGGLAGLTTALFLGLNGVRPLVAEKHPGTSVVMK
                     ARGQYPHTMEALRIGGIADRIAAAGPDGGTGEFYMVVADSLAGPVLKRIMTEGEMAMRH
                     VSPEDWAMAGQERTEEILADRAAELGAELRFDTELVSLTQSADAATAVLRDVRTGTERT
                     VTADHVVGADGAHSHVRRELGIGMHGRGDLGEIFRVFFDADLSEQLRELPGVAEGRKFT
                     LLWLQQPVPGVFYTTDVPGRYGYVLGMSQDPPDFAGFTEERCAELVRTGLGLPDLPLKV
                     VETGRTDIVSEIADRFSSGRVHLVGDAARLVPAPGGLGGNTAITDGFYLAWKLAMVVKG
                     EAGPGLLDSHDAERRPVSEMIGEQQLRNTVERLADYLDDGALAAPLPPVVQAFGYRCAG
                     GAVVREPDDAGELLEDPAAPTGRPGSRAPYVALPAGSPAASTTALFGRSFVLLTGDGTP
                     DAWTTAAAAAAERLGITLPVHRLAGTEWEKSYGVSGAGAVLVRPDRFVAWRSTGPAADG
                     DAARQALESALRTVLDRPLPAHDAP"
     gene            4958..5254
                     /gene="plqT"
     CDS             4958..5254
                     /codon_start=1
                     /gene="plqT"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000087: Hydroxylation (63% identity)"
                     /gene_kind="biosynthetic-additional"
                     /product="AknX family monooxygenase"
                     /protein_id="QFS19037.1"
                     /transl_table=11
                     /translation="MFVFVNKLTLTGAAEDLERVYAHVAEFMRTRPGLVRYQLVRSQGD
                     PSVYFNVAEWTDQASFEQALKEPEFRSRLKALGTVVKGEPHLSDLVESGVGEA"
     gene            5259..5699
                     /gene="plqS"
     CDS             5259..5699
                     /codon_start=1
                     /gene="plqS"
                     /product="cyclase"
                     /protein_id="QFS19038.1"
                     /transl_table=11
                     /translation="MSGPLKISNPVDGETYSRITQFYAHQMQLLDERAAEEWADGFTED
                     GVFAQNVKPEPWTGRAVIAERMRAGMDRLAKKDVQRRHWFGMVATERQDAETVLTRYYA
                     MVFETPRGGRAATYLSTTGEDVLVLQDGQWRVKHRLITHDGT"
     gene            5739..6200
                     /gene="plqQ"
     CDS             5739..6200
                     /codon_start=1
                     /gene="plqQ"
                     /product="unknown"
                     /protein_id="QFS19039.1"
                     /transl_table=11
                     /translation="MSKLTRERVAAAYASLVTGDREQILQYWSPDVRFQMPGNHQYSGW
                     FVGLDDYLAKMGKLMAATGGRISSETLDVLIDEEAGVSIDVYRLDGYREHAKEDATSPY
                     ERLQVEGVHMLRWEDGRIVEGRSALFADGVTQGNLWWSPVGADGERYEY"
     gene            6270..7037
                     /gene="plqP"
     CDS             6270..7037
                     /NRPS_PKS="Domain: PKS_KR (13-124). E-value: 3.3e-08.
                     Score: 25.6. Matches aSDomain:
                     nrpspksdomains_plqP_PKS_KR.1"
                     /codon_start=1
                     /gene="plqP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /product="OxyM family protein"
                     /protein_id="QFS19040.1"
                     /sec_met_domain="adh_short (E-value: 1.5e-31, bitscore:
                     100.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 9.3e-33, bitscore:
                     104.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPAQGLLQDRAVVITGGGTGIGRAAAHAFAAEGARVLVVGRRA
                     GVLAETAGGHEGIRTFRADLADPGAARAVVEAAGDALGGIDVLVNNAVTMRSAPLGHID
                     RDNARDQVATNLLGPLFLTQEALPALEAAKGLVVNVTTAGNQRGWAGHSVYGATKAGLD
                     FLTRTWALELAPRGIRVAGIAPGPIETPIAEHAGLDAEGIARLRARQRDRVPLGRVGRP
                     EEVAWWMVALARPEASFATGLVLPVDGGASVVF"
     CDS_motif       6309..6392
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqP_0001"
                     /evalue="3.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="plqP"
                     /protein_end="41"
                     /protein_start="13"
                     /score="16.4"
                     /tool="antismash"
                     /translation="VVITGGGTGIGRAAAHAFAAEGARVLVV"
     aSDomain        6309..6641
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqP_PKS_KR.1"
                     /evalue="3.30E-08"
                     /label="plqP_PKS_KR.1"
                     /locus_tag="plqP"
                     /protein_end="124"
                     /protein_start="13"
                     /score="25.6"
                     /tool="antismash"
                     /translation="VVITGGGTGIGRAAAHAFAAEGARVLVVGRRAGVLAETAGGHEGI
                     RTFRADLADPGAARAVVEAAGDALGGIDVLVNNAVTMRSAPLGHIDRDNARDQVATNLL
                     GPLFLTQ"
     gene            7072..8145
                     /gene="plqO"
     CDS             7072..8145
                     /codon_start=1
                     /gene="plqO"
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /product="luciferase-like monooxygenase"
                     /protein_id="QFS19041.1"
                     /transl_table=11
                     /translation="MEFGINFFPTVGPDDKDAADYFEDSLNLVVLAEELGFDHVKTVEH
                     YFFKYGGYSPDPVTFLAAAAARTSRIKLVTGAVIPAFTHPLKLAGKLAMLDNISRGRLQ
                     VGFGRAFLPDEFDAFGIDMDESRARFEEGVRACRKLWSEEDVVWDGAFHSFGPVTLLPR
                     PHQRPHPPILVATAKTASSCEQAGRDGHGLMMVPSINKRETVQDMLALYRKAWAEAGHP
                     GQGEVHMSYNCYLSEDAAEARAKGKEYSRRSNEVMRDAVAAWGERRSEVYAGYEKVVEN
                     IARADFDRSLADNKVLVGTPEEVTERLRTIREWFGDISVSLQVISGNPSHEESARSMRL
                     FAEQVVPHFRTAPAAAG"
     gene            complement(8237..9709)
                     /gene="plqN"
     CDS             complement(8237..9709)
                     /codon_start=1
                     /gene="plqN"
                     /product="oxidoreductase"
                     /protein_id="QFS19042.1"
                     /transl_table=11
                     /translation="MERQQHRADVVIVGSGYGGSIAALRLAEAGVDAVLLERGRRWPVD
                     DAGDTFATQAAPDGRAAWLSETSPLTDAKLDVHTGVLEFVEGSGMNVLAGTGVGGASLA
                     TNGTMCEPPAELFRRTLGDVLDHREMHERWYPEARELIGCAPIPDDVYHSEFYRSARSF
                     ADQLDKAGIPWDKVDLAVDWDVVREEMAGTRVRSQIDGLNVFGVNSGAQRSLDRTVLAR
                     AEASGHIDVRPLSVVTAVRPAEGGSGYHVDYESIDERGEVLRRHRITAGRLVLSAGTLG
                     TNRLLLRARESGALPALHAALGTRVGNSEVITARTGMDENNARQGGPAAILARDWEDNP
                     LGPVSLLNFPWPQAPEGEGWTTTIGAVPAPALGAFRHDPATDDVVLHWPADDPALERAQ
                     SAIGHTLDRLNEANPGSRTAFSRIGTTGGNVVGGVPLGTVTDDAGRVDGYRGLYVVDGS
                     LLPGTGVPPALTVAAVAARVTSTLVRDVVRPR"
     gene            10044..11102
                     /gene="plqM"
     CDS             10044..11102
                     /NRPS_PKS="Domain: PKS_AT (21-300). E-value: 1.1e-69.
                     Score: 227.0. Matches aSDomain:
                     nrpspksdomains_plqM_PKS_AT.1"
                     /codon_start=1
                     /gene="plqM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /product="ZhuC family acyltransferase"
                     /protein_id="QFS19043.1"
                     /sec_met_domain="PKS_AT (E-value: 4.3e-70, bitscore: 227.0,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPTPSPPSPSPSPAPRGVALLFPGQGAQQHLMAAGLYHAHPPFR
                     RLVDEVFEVWGAEGAALRADWLSGSPDVDLDGVHRAQPLLFAVDWALGRLVLDWGVRPA
                     ALLGHSVGEVAAATLAGVFTLEEAAGLMADRVAHIASAPAGGMLAVHAAADDMAPYLHA
                     DVVVGAVNAPRQVILAGSEQPLAESEARLRAAGFTCRRTRALSPFHSPALAPAARAALP
                     ALSRLPLRAPRLALHSAYTGGPLSPDEARDARFWAGQPAAPVLFGPTLDALLGTGELLL
                     LEAGPGQGLTALAKRHPAVGTGRSTARAMLPARARGDASDLRTLRTAVEALAAEGWPVP
                     DRLPVAAPASTP"
     CDS_motif       10107..10157
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqM_0001"
                     /evalue="1.30E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="plqM"
                     /protein_end="38"
                     /protein_start="21"
                     /score="14.6"
                     /tool="antismash"
                     /translation="LFPGQGAQQHLMAAGLY"
     aSDomain        10107..10943
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqM_PKS_AT.1"
                     /evalue="1.10E-69"
                     /label="plqM_PKS_AT.1"
                     /locus_tag="plqM"
                     /protein_end="300"
                     /protein_start="21"
                     /score="227.0"
                     /tool="antismash"
                     /translation="LFPGQGAQQHLMAAGLYHAHPPFRRLVDEVFEVWGAEGAALRADW
                     LSGSPDVDLDGVHRAQPLLFAVDWALGRLVLDWGVRPAALLGHSVGEVAAATLAGVFTL
                     EEAAGLMADRVAHIASAPAGGMLAVHAAADDMAPYLHADVVVGAVNAPRQVILAGSEQP
                     LAESEARLRAAGFTCRRTRALSPFHSPALAPAARAALPALSRLPLRAPRLALHSAYTGG
                     PLSPDEARDARFWAGQPAAPVLFGPTLDALLGTGELLLLEAGPGQGLTALAKRHPAV"
     CDS_motif       10341..10448
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqM_0002"
                     /evalue="3.90E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="plqM"
                     /protein_end="135"
                     /protein_start="99"
                     /score="54.3"
                     /tool="antismash"
                     /translation="GVRPAALLGHSVGEVAAATLAGVFTLEEAAGLMADR"
     gene            11212..12480
                     /gene="plqA"
     CDS             11212..12480
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-393). E-value:
                     4.1e-52. Score: 169.4. Matches aSDomain:
                     nrpspksdomains_plqA_PKS_KS.1"
                     /codon_start=1
                     /gene="plqA"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ene_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /product="ketosynthase alpha subunit"
                     /protein_id="QFS19044.1"
                     /sec_met_domain="t2ks (E-value: 1.6e-233, bitscore: 765.7,
                     seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 7.9e-54, bitscore:
                     173.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 3.6e-43, bitscore: 138.5,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 4.7e-46, bitscore: 148.0,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 7.8e-42, bitscore: 134.1,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 3.9e-50, bitscore: 161.4,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 2.9e-33, bitscore: 105.6,
                     seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERRIVITGIGAVAPGKPGAKEYWELISNGRTATRTISSFDPAPY
                     RSRVAAECDFDPLAAGLGRQEVRRMDRATQFAVAAAREAVADSGLDLPADDPAAVGVSL
                     GNAVGCTTSMEEEYTVLSNEGSDWLVDHHYAVPHLYDHFVPSSIAVELARLVGAQGPVA
                     LVSDGCTSGLDAIGHATDLIREGSADVVISGGTDAPISPITLACFDAIKATTPRNDDPE
                     HASRPFDATRNGLVLGEGAAVLVLEELEHARRRGARIYAEVAGVGTRCNAYHMTGLRSD
                     GAEMADAITHALAEARLAPESIDYVNAHGSSTKQNDRHETAAFKTALGRHAYDVPVSSV
                     KSMIGHSLGAIGALELVACVLAMRDGLVPPTANLHEPDPVCDLDYVPLRAREAEVDNVL
                     SVGSGFGGFQTAIVLARPERAAA"
     aSDomain        11224..12390
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqA_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.10E-52"
                     /label="plqA_PKS_KS.1"
                     /locus_tag="plqA"
                     /protein_end="393"
                     /protein_start="4"
                     /score="169.4"
                     /tool="antismash"
                     /translation="IVITGIGAVAPGKPGAKEYWELISNGRTATRTISSFDPAPYRSRV
                     AAECDFDPLAAGLGRQEVRRMDRATQFAVAAAREAVADSGLDLPADDPAAVGVSLGNAV
                     GCTTSMEEEYTVLSNEGSDWLVDHHYAVPHLYDHFVPSSIAVELARLVGAQGPVALVSD
                     GCTSGLDAIGHATDLIREGSADVVISGGTDAPISPITLACFDAIKATTPRNDDPEHASR
                     PFDATRNGLVLGEGAAVLVLEELEHARRRGARIYAEVAGVGTRCNAYHMTGLRSDGAEM
                     ADAITHALAEARLAPESIDYVNAHGSSTKQNDRHETAAFKTALGRHAYDVPVSSVKSMI
                     GHSLGAIGALELVACVLAMRDGLVPPTANLHEPDPVCDLDYVPLRAREA"
     CDS_motif       12235..12309
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqA_0001"
                     /evalue="4.90E-03"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="plqA"
                     /protein_end="366"
                     /protein_start="341"
                     /score="9.9"
                     /tool="antismash"
                     /translation="SMIGHSLGAIGALELVACVLAMRDG"
     gene            12773..13633
                     /gene="plqB"
     CDS             12773..13633
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (18-283). E-value:
                     2.8e-23. Score: 74.4. Matches aSDomain:
                     nrpspksdomains_plqB_PKS_KS.1"
                     /codon_start=1
                     /gene="plqB"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) tra_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /product="ketosynthase beta subunit"
                     /protein_id="QFS19045.1"
                     /sec_met_domain="t2clf (E-value: 6.6e-126, bitscore: 410.8,
                     seeds: 26, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 7.6e-23, bitscore: 71.5,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 1.8e-22, bitscore: 70.2,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.2e-18, bitscore:
                     58.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 2.4e-17, bitscore: 53.4,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 1.2e-20, bitscore: 64.3,
                     seeds: 44, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAGGRFVSAYQSFAWFYAVNTGQVSIRHGLRGSSSTVVTDAAGG
                     LDALGNARRQIRKGTTAMLAGSVDGALCPLGLAGQLSSGAMSTGSRADRAFLPFADGAG
                     GQVPGEGGAFLVLEDAVSARRRGARSYGELAGYAATFDPAPVPSDQAGEGLVRAIRRAL
                     RDAGTAPEDVDVVFADAAGVPELDRAESRALGEVFGPGGVPVTAPKSMTGRLFAGGASL
                     DLATALLALRDGAIPHTANVSRPGPGHPIDLVTGEPREADLRRALVVARGRGGFNAAAV
                     VRRDT"
     aSDomain        12827..13621
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqB_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.80E-23"
                     /label="plqB_PKS_KS.1"
                     /locus_tag="plqB"
                     /protein_end="283"
                     /protein_start="18"
                     /score="74.4"
                     /tool="antismash"
                     /translation="AVNTGQVSIRHGLRGSSSTVVTDAAGGLDALGNARRQIRKGTTAM
                     LAGSVDGALCPLGLAGQLSSGAMSTGSRADRAFLPFADGAGGQVPGEGGAFLVLEDAVS
                     ARRRGARSYGELAGYAATFDPAPVPSDQAGEGLVRAIRRALRDAGTAPEDVDVVFADAA
                     GVPELDRAESRALGEVFGPGGVPVTAPKSMTGRLFAGGASLDLATALLALRDGAIPHTA
                     NVSRPGPGHPIDLVTGEPREADLRRALVVARGRGGFNAAAVVR"
     gene            13782..14057
                     /gene="plqC"
     CDS             13782..14057
                     /NRPS_PKS="Domain: ACP (18-86). E-value: 2.8e-15. Score:
                     48.4. Matches aSDomain: nrpspksdomains_plqC_ACP.1"
                     /codon_start=1
                     /gene="plqC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129: acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl carrier protein"
                     /protein_id="QFS19046.1"
                     /sec_met_domain="PP-binding (E-value: 2.7e-11, bitscore:
                     34.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDANTAVTELSVEDLTSIMRSSAGEDESVDLDGDILDSAFTDLG
                     YDSLALLETVARISRDHGVELGDDVLDDVETPRDLLAVVNRAIAAA"
     aSDomain        13836..14039
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqC_ACP.1"
                     /evalue="2.80E-15"
                     /label="plqC_ACP.1"
                     /locus_tag="plqC"
                     /protein_end="86"
                     /protein_start="18"
                     /score="48.4"
                     /tool="antismash"
                     /translation="IMRSSAGEDESVDLDGDILDSAFTDLGYDSLALLETVARISRDHG
                     VELGDDVLDDVETPRDLLAVVNR"
     gene            complement(14136..15239)
                     /gene="plqD"
     CDS             complement(14136..15239)
                     /codon_start=1
                     /gene="plqD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /product="phosphotransferase"
                     /protein_id="QFS19047.1"
                     /sec_met_domain="APH (E-value: 5.5e-24, bitscore: 76.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVPVQRDSEETRLALAGWFEARTPGAGEVRIGPVGVPGAAGFSG
                     EILLCDAEWTEDGATRREPLAVRVAPTGHRVLPDDRWTEQVRLLEALDGTDVPVAPLLG
                     HEPGASVLGAPFLVMRRIEGQVPADLPSYHREGWLAELPPHDRRAVWLGGVEMLAAVHR
                     LDPVALGLGFLDRPQYGTGHLTQQLAEYTELLPFYGADGNEAATAALAWLHAHRPAESG
                     RPRLLWGDARLGNIVYDGVTPAAVLDWEMAGLGRPESDLAWFLHLDRHLSEGIGAARLA
                     GLPDRAETVRHYERLTGHTVRDLEYYEVFAAFRFCLLTARVTRLLEESGIMPPGTDFPL
                     HRNATRLLARVLEETGALQGGTAAAGR"
     gene            15480..16217
                     /gene="plqE"
     CDS             15480..16217
                     /NRPS_PKS="Domain: PKS_KR (6-164). E-value: 1.8e-16. Score:
                     52.5. Matches aSDomain: nrpspksdomains_plqE_PKS_KR.1"
                     /codon_start=1
                     /gene="plqE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /product="ketoreductase"
                     /protein_id="QFS19048.1"
                     /sec_met_domain="adh_short (E-value: 3.6e-36, bitscore:
                     115.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLQGRTAVVTGGTRGLGRAVAQALADAGAVVVAAARDVQAAQPD
                     PVAGGGRIVQVKADVTVPQSVEELMRTAHERYGGPHIVVANAGVSRPGPVSVLSGEDWD
                     TVIGTNLTGVFHTVRAAVPFLQEAGPGRVITVSSLLGRRAMPGAAAYCASKAAVERFTE
                     VCALELAPKDITVNCLSPGFIEEGQGRALMANEVLWPRLRDTLAAGRPGTGAEVARAAV
                     FLASAESSYVNGAVLPVDGGVRW"
     aSDomain        15498..15971
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqE_PKS_KR.1"
                     /evalue="1.80E-16"
                     /label="plqE_PKS_KR.1"
                     /locus_tag="plqE"
                     /protein_end="164"
                     /protein_start="6"
                     /score="52.5"
                     /tool="antismash"
                     /translation="TAVVTGGTRGLGRAVAQALADAGAVVVAAARDVQAAQPDPVAGGG
                     RIVQVKADVTVPQSVEELMRTAHERYGGPHIVVANAGVSRPGPVSVLSGEDWDTVIGTN
                     LTGVFHTVRAAVPFLQEAGPGRVITVSSLLGRRAMPGAAAYCASKAAVERFTEV"
     CDS_motif       15504..15575
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqE_0001"
                     /evalue="6.70E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="plqE"
                     /protein_end="32"
                     /protein_start="8"
                     /score="25.2"
                     /tool="antismash"
                     /translation="VVTGGTRGLGRAVAQALADAGAVV"
     gene            16320..17066
                     /gene="plqF"
     CDS             16320..17066
                     /NRPS_PKS="Domain: PKS_ER (40-246). E-value: 1.8e-21.
                     Score: 68.5. Matches aSDomain:
                     nrpspksdomains_plqF_PKS_ER.1"
                     /codon_start=1
                     /gene="plqF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /product="oxidoreductase"
                     /protein_id="QFS19049.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-17, bitscore:
                     54.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGTPADGTAAGPVERTPVGPSPCLPARHAAAGFTAGFPGTVPDG
                     VEWTDAAAVPVAGLTALYALRNAGSLLGRRVLVTGASGGVGRIAVQLARASGAEVSAWA
                     GSAERLKGLAELGAAEAATYEAGPGVTQPVHVLVDSVGGEVFRSAYQLVGQRGVVVCYG
                     NTTRSDLSLPFDWGHARPGVRIRYLHLFDEMPRRPVGEDLGVLLRLVAEGALDPQVTLV
                     GDWSDPDPVLRGVGDRQVNGKAVLVF"
     aSDomain        16440..17057
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqF_PKS_ER.1"
                     /evalue="1.80E-21"
                     /label="plqF_PKS_ER.1"
                     /locus_tag="plqF"
                     /protein_end="246"
                     /protein_start="40"
                     /score="68.5"
                     /tool="antismash"
                     /translation="TVPDGVEWTDAAAVPVAGLTALYALRNAGSLLGRRVLVTGASGGV
                     GRIAVQLARASGAEVSAWAGSAERLKGLAELGAAEAATYEAGPGVTQPVHVLVDSVGGE
                     VFRSAYQLVGQRGVVVCYGNTTRSDLSLPFDWGHARPGVRIRYLHLFDEMPRRPVGEDL
                     GVLLRLVAEGALDPQVTLVGDWSDPDPVLRGVGDRQVNGKAVL"
     CDS_motif       16470..16514
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqF_0001"
                     /evalue="6.80E-04"
                     /label="PKSI-ER_m4"
                     /locus_tag="plqF"
                     /protein_end="65"
                     /protein_start="50"
                     /score="13.1"
                     /tool="antismash"
                     /translation="AAAVPVAGLTALYAL"
     CDS_motif       16536..16598
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqF_0002"
                     /evalue="1.30E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="plqF"
                     /protein_end="93"
                     /protein_start="72"
                     /score="20.9"
                     /tool="antismash"
                     /translation="GRRVLVTGASGGVGRIAVQLA"
     gene            complement(17300..17950)
                     /gene="plqG"
     CDS             complement(17300..17950)
                     /codon_start=1
                     /gene="plqG"
                     /product="unknown"
                     /protein_id="QFS19050.1"
                     /transl_table=11
                     /translation="MNARAQTGSAPAVDLTMMYAIHHAFRRDLRLLEEAQHDDLAAFRQ
                     GWQRFKTYLTIHHLAEDHSLWPVLRTKLAGQKEALEMLRAMEVEHAQLDTAVEKIDAAL
                     GRQGGERALPDLMEDVAACLLDHLDHEEAQALPLVESELSAAEWDAFVTEQRTQVGIKG
                     AATFFPWLLDGVPEDERRNVLDRVPAPLRLVYRGVWRPRYERNSPWKGGAAAS"
     gene            complement(18018..19589)
                     /gene="plqH"
     CDS             complement(18018..19589)
                     /codon_start=1
                     /gene="plqH"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /product="Alp1R family transporter"
                     /protein_id="QFS19051.1"
                     /transl_table=11
                     /translation="MSEQSLGQAHASPSASPPAGAATGSPSRKGLALTAIAVAQLMVVL
                     DVSIVNVALPSIQSALDFSATNLEWVVNAYALAFGGLLLLGGRIADMYGQRRTLLFGIG
                     LLTVSSLLGGLATNQGWLIGARAVQGVAGALIAPAALALIASTFSEGAERNKAMGIYAA
                     MGGAGGALGNVLGGVFTDALSWRWVLFVNVPIGVLLLLAAVKAFPAERVTTGGRRLDLP
                     GAVTSTVGMSLVVYGLIHAATDDWGSAGTVLPLAVGAALLAVFLFIEFRTDSPLMPPSI
                     FRNRNRSGAYAIMLALGAGMIALFYFLTLFMQIVLGFSPLKTGFAFLPFAVGAAVFATI
                     SSQVVGRVGPRILLGAGTLLAAVAFFWFSQLSENGSYSGDLLGPLSLAGCSVGLCFVPL
                     TLAAVAGVRKAQAGVSSALLNAGQQVGAALGLAALGTVAISATKDRLTELMGAAAAESA
                     EGYGPADAANMPPEVRKAVFDSLAQGYGTAFMVAGFVLLGAFVLAVLVLRVSSKDAEDA
                     EMGVVI"
     gene            19864..20814
                     /gene="plqI"
     CDS             19864..20814
                     /codon_start=1
                     /gene="plqI"
                     /gene_functions="resistance (resist) SubclassB1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /product="cyclase"
                     /protein_id="QFS19052.1"
                     /transl_table=11
                     /translation="MTQPSATPRTGTPPAQDPPRLEELAPGVHAYVQPDGGWCLNNAGV
                     LIGDGAVAVVDTAATERRARALRAAVASRTPLEVGTIVTTHHHGDHHFGNSVVAPHATV
                     VSHEVTRNEMARRGLAMREVWPDTDWGDLRLALPTLTFRDRATLHVGGLTAELIHVGPA
                     HTTSDIVVWLPEQRVLFAGDVLLPGCTPFVLMGSLSGTLEAITRLRALDPAVVVGGHGP
                     VAGPEVLDDTRDYLLWVRDTARAGLAAGASPLQAARDAGLGPYAGLRDSERLVANLHRA
                     YVEESSRPRDTEIRSAPVFAEMAEFNGGRPVACHA"
     gene            complement(21035..21976)
                     /gene="plqJ"
     CDS             complement(21035..21976)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-147). E-value: 3e-16.
                     Score: 52.0. Matches aSDomain:
                     nrpspksdomains_plqJ_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (156-292). E-value:
                     7e-08. Score: 24.9. Matches aSDomain:
                     nrpspksdomains_plqJ_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene="plqJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128: cyclase/dehydrase"
                     /gene_kind="biosynthetic-additional"
                     /product="START domain family cyclase"
                     /protein_id="QFS19053.1"
                     /transl_table=11
                     /translation="MAVTHHARHTITVDAPARTVYDIVADAADWPRVFPPSVHVERTPL
                     GDGEEALRIWATANDEVKHWQSRRWLDPEALTVAFRQERTTAPATSMGGRWQIRALSDG
                     RCEVVLLHDFTAQDDDPGNVEWINRALDRNSEAELSRMKATAESAGELGELLCTFEDRV
                     RIEAPIADVHAFLWRGEQWQDRLPHVARVKLSEPEDDIQVLEMDTLAKDGSRHTTESVR
                     VSLGPSRIVYKQLRVPPLLTAHVGEWLLEEADGGTTAVARHTVVINPSSVTLLGPDTTV
                     AGARTFIRETLGANSLATLRHAKEFTEPSPAR"
     aSDomain        complement(21101..21508)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqJ_Polyketide_cyc2.2"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="7.00E-08"
                     /label="plqJ_Polyketide_cyc2.2"
                     /locus_tag="plqJ"
                     /protein_end="292"
                     /protein_start="156"
                     /score="24.9"
                     /tool="antismash"
                     /translation="CTFEDRVRIEAPIADVHAFLWRGEQWQDRLPHVARVKLSEPEDDI
                     QVLEMDTLAKDGSRHTTESVRVSLGPSRIVYKQLRVPPLLTAHVGEWLLEEADGGTTAV
                     ARHTVVINPSSVTLLGPDTTVAGARTFIRETL"
     aSModule        complement(21101..21964)
                     /domains="nrpspksdomains_plqJ_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_plqJ_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="plqJ"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        complement(21536..21964)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqJ_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.00E-16"
                     /label="plqJ_Polyketide_cyc2.1"
                     /locus_tag="plqJ"
                     /protein_end="147"
                     /protein_start="4"
                     /score="52.0"
                     /tool="antismash"
                     /translation="HHARHTITVDAPARTVYDIVADAADWPRVFPPSVHVERTPLGDGE
                     EALRIWATANDEVKHWQSRRWLDPEALTVAFRQERTTAPATSMGGRWQIRALSDGRCEV
                     VLLHDFTAQDDDPGNVEWINRALDRNSEAELSRMKATAE"
     gene            complement(22054..22851)
                     /gene="plqK"
     CDS             complement(22054..22851)
                     /NRPS_PKS="Domain: PKS_KR (11-170). E-value: 1.4e-11.
                     Score: 36.5. Matches aSDomain:
                     nrpspksdomains_plqK_PKS_KR.1"
                     /codon_start=1
                     /gene="plqK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /product="ketoreductase"
                     /protein_id="QFS19054.1"
                     /sec_met_domain="adh_short (E-value: 5.4e-37, bitscore:
                     118.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEPQSGESRVAFVTGATRGIGRAVAETLGGAGIKVFITARNAE
                     DVTATVKELTEAGITVDGTAADVRSGDDVARSVATAVERFGPIDILVNNAGRSGGGVTA
                     QITDELWNDVVETNLTSVFRVTREVLNAGGMAAKSVGRIINIASTGGKQGVMLGAPYSA
                     SKHAVVGFTKSLGLELAKTGITVNAVCPGYVETPMAKRVREGYAGHWEVAEEEVLKRFE
                     AKIPLGRYTAPGEVAALVAYLAGPAAAPVTAQAINVCGGLGNY"
     aSDomain        complement(22342..22818)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plqK_PKS_KR.1"
                     /evalue="1.40E-11"
                     /label="plqK_PKS_KR.1"
                     /locus_tag="plqK"
                     /protein_end="170"
                     /protein_start="11"
                     /score="36.5"
                     /tool="antismash"
                     /translation="VAFVTGATRGIGRAVAETLGGAGIKVFITARNAEDVTATVKELTE
                     AGITVDGTAADVRSGDDVARSVATAVERFGPIDILVNNAGRSGGGVTAQITDELWNDVV
                     ETNLTSVFRVTREVLNAGGMAAKSVGRIINIASTGGKQGVMLGAPYSASKHAVVG"
     CDS_motif       complement(22759..22809)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plqK_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="plqK"
                     /protein_end="31"
                     /protein_start="14"
                     /score="11.7"
                     /tool="antismash"
                     /translation="VTGATRGIGRAVAETLG"
     gene            23059..23580
                     /gene="plqL"
     CDS             23059..23580
                     /codon_start=1
                     /gene="plqL"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="ActVB family FMN reductase"
                     /protein_id="QFS19055.1"
                     /transl_table=11
                     /translation="MGTTSPARDHTDAAVPVSSGTLRGVLREVPTAVTVVTATTEGGPA
                     GLTVGSFVSVSLDPPLIGIFVDEKSSSWPEMRRSATFTVNVLSGDQQELCARFASSGGD
                     KFAGLTPATSPLGNPLLPGVAAWLDCRVEEIRKLGDHHFALARVAGLGRPATAGSTSIV
                     FHRGALHAVP"
ORIGIN
        1 cggaatccaa ccgcccattt tgccgcatcg cttatatccc tcacgaggac gaacgcaccg
       61 aattcaagcg gagccccatt cttcaccgag accctaaacg ggactgagtc atgagccggt
      121 aactaccgcc cccgacggac cgcagagcgg accgttaccg ctgggttccg ctccgaccca
      181 aggaatgttt ccgcaggtca cgagctgtaa ttgcgaggaa gcccggaggg tgttgaccgc
      241 cggttgacgg cagatgtgca cacccgatta accttcgttc caattcggcg atttcgcgcc
      301 gcacaacaca gggggtactg accaccccgc cgaacgcggg cgatacgaat cctgtcacta
      361 ttccggaagg tgtgcgagac cgacgtggaa ttctccgtac tgggacccct gcgcatgtac
      421 gagggcggga agtcctacac gccgacagcc ccgaagcagc gacagctgct cactctgctg
      481 ctcctcaacg cgaaccaggt cgtgtccacc gacacgtgca tcgaagagct gtgggagaac
      541 tcccctccca acagcgcact ctccactctc cagtcgtaca tactccagct caggcgcagt
      601 ttgcggcggg tgccccggat cggcagcctc caggcggccc gtctcatcct ggaaacccgc
      661 gacggcggct atctgctggc cgtgcgcagc gacgaactcg acaccaaccg gttctggtcc
      721 ctggtgcgcg aaggccgttc ggcgctccac cacgacgacg tgcgggcctc ggcctgtctc
      781 tccgaagccc tgcggctgtg gcaggggtcc gcgctctccg acgtacagcg cggtcccgtc
      841 ctgcgggccc tgctcgtcgg cctggaggag gagcgcacga gcgtgcagga gcagcgcatc
      901 gcagcggacc tgcggctcgg caggcaccag gagctgctgg gggagctgag ccggctcacg
      961 gccaagtacc ccatgcacga aggcctgcac gcccagttca tgctcgcgct gcaccgcacc
     1021 ggccgccgga cccaggcgct cgaggtgctg cggcggctgg gcaccgtgct ccgcgacgag
     1081 ctggggctcg acccctcacc gcgggtgcgc cggctgcacc aggcgatcct ggccggcgac
     1141 cccgccctcg acgtcccggc gcgcaccgac tccgtgctga ccgccgaacc cggcgcgccg
     1201 atcgggcgcc ggctgcccgc gggcggcgac ctggtggccg tcggagcggc cgccgggcgc
     1261 ccggagcagc tcgtgcgacg ctgagcgagt gccacgccgc gccggcgggg cggaagcggc
     1321 gcgtccctcg gcggggcggc gcctcggccc tcgccgtccc caccgcggcg ccccgccgcg
     1381 gcgccccgcc gcggcgcctc agcgctcgcc gtcccccacc gcggcgcccg gccgggacga
     1441 cgcgttggcc gcgaggaagc cgtcgacgac ggtccgcacg tactccgcgc cgaaggtgcg
     1501 ctccgcgagg agccgtcgga acatcagcgg gcccgcgagc tggtcgatgg ccagctcggt
     1561 gtccaggccg ccggggagtt cgccgctctc cttcgcccct tcgatgatcg cgcggaaccc
     1621 tccggagccc gcctggtaca gcgcctcctt gagcccggcg aaggccgggt cgacaccggc
     1681 ccgctcgacg accacccgca tcccgcgctc gcccaccggg tcgtgcagca gggcccgcag
     1741 accgttgagc tggccgatca ggtcgtcgcg gagcacgccg ctgcgcgtgg ggcgggcgct
     1801 cgcgatgcgc tgggcgatgg cctcgtagat gagggacggg gagtccggcc agtggcggta
     1861 cagggtggtg cggcccacgc cgctgcgggc cgcgacggcg acgtgggtga ccgcggacca
     1921 cccctgttcc acgagcagtt cctgggcggc cgcgagggcg gcggcccggc tgcgggccgc
     1981 ccgtgggtcc atgccgcgct ccggcgccgg cgggatgtgt cctgtggcgt cggcaggcgt
     2041 ggacatgtcg gctccccgtg gttcgttgat ctgctgtccg gtacagagtg tgccagttct
     2101 cccaccggcc cgcccgggcg ggccggtccc ccgggccggg cacgaagccg tcaggagcgg
     2161 tagaggtcca ggtggtcgcg ggcccactcg gcgaaggagc gcggctcccg gcccaggacc
     2221 cggcggacgt cgggcgacag ccggccgtgc agttcgctgc cgtgctcgat cgcctcctcc
     2281 agcgtcctga tcaccccgtt cacggtctcc tcggagaagt gacgcagcat cgtctcgcgg
     2341 tgcgcggcga gcggaacggt ctcgaagcgc aggtccctcc cgagcagccc ggcgagcacg
     2401 gcgagctgct cgcggccggt cagcgcctgc gggccggtca gttcgtggat ccggccctcg
     2461 tggccgtcct cggtgagcgc ccgcgccgcc acctcggcga tgtcccgcgg gtcgacgatc
     2521 gcctccggga cgtccgcgag cgggccgcgg gcgactccct cggccttgat cgaggcggcc
     2581 cagccgaggt tcatgctcat gaagccgttc ggccgcagaa tcgtccaggg cagcccggag
     2641 tcccgcagtg cctcctcggc gatccggtgc cagtggccga gcgggttcgc ccgcgcgtcc
     2701 tcggccacct ccaccccgag ggtggagagc tgcacgatgt gctcgactcc ggccgcccgc
     2761 gcggcggcca ccatgtgcgc gtcgtgggtc gccttgttcg cgccgagcga catcaggaag
     2821 accttctgta cgccgtccag tgcgggcgcc agtgtcccgg ggcgccccag gtcggcggcg
     2881 accacctcca ggtccgcccc ctcggggaac gccacccgct gcgggtcgcg ggtgagcgcc
     2941 cgcaccttgt gcccgcccgc acgcagcagc gacagcacct ttccgcccac gtttcccgtg
     3001 gctccggtca ccagaatcat gttcgtctcc ttgtccgtcc gtacatgtgc gggatggttc
     3061 gaggggccgg tgcctatggg gcgtcgtgcg ccgggagggg gcggtccagg acggtgcgca
     3121 gggcgctctc cagcgcctga cgcgcggcgt cgccgtccgc ggccggtccg gtggagcgcc
     3181 aggcgacgaa gcggtcgggc cgcaccagta ccgctcccgc cccgctcacg ccgtagctct
     3241 tctcccactc ggtgccggcg agccggtgca ccggcagggt gatgccgagg cgttcggccg
     3301 ccgcggcggc cgcggtcgtc caggcgtccg gtgtgccgtc cccggtgagg aggacgaagg
     3361 agcggccgaa cagcgcggtg gtggacgcgg cgggcgagcc cgcgggcagt gccacgtagg
     3421 gcgcccggga accggggcgg ccggtcgggg cggccgggtc ctccagcagc tcccccgcgt
     3481 cgtcgggctc gcggacgacc gcgccgcccg cgcaccggta gccgaaggcc tggacgacgg
     3541 gcgggagcgg cgcggcgagc gctccgtcgt ccaggtaatc cgccagtcgt tcgacggtgt
     3601 tgcgcagctg ctgctccccg atcatctccg agaccggacg gcgttcggcg tcgtggctgt
     3661 cgagcaggcc gggtccggcc tcgcccttga cgaccatcgc cagcttccac gccaggtaga
     3721 agccgtcggt gatcgcggtg ttgccgccca ggccgccggg cgccggcacc agcctggccg
     3781 cgtcgcccac caggtggacg cggccgctgc tgaaccggtc ggcgatctcg ctgacgatgt
     3841 cggtgcgccc cgtctccacg accttcagcg gcaggtcggg caggcccagg ccggtgcgga
     3901 ccagttcggc gcaccgctcc tcggtgaagc cggcgaagtc gggcgggtcc tgggacatgc
     3961 cgagcacgta gccgtaacgg ccgggcacgt ccgtggtgta gaagacgccc ggtacgggct
     4021 gctggagcca caggagcgtg aacttgcggc cctccgcgac cccgggcagc tcacgcagct
     4081 gttcactcag gtcggcgtcg aagaagaccc ggaagatctc gccgaggtcg ccgcggccgt
     4141 gcatgccgat gcccagttcc cgtcgcacgt ggctgtgggc gccgtcggcg cccaccacgt
     4201 ggtcggcggt caccgtgcgc tcggtgccgg tgcgcacgtc cctcagcacg gcggtggccg
     4261 cgtccgccga ctgggtcagc gacaccagtt cggtgtcgaa gcggagttcg gcgccgagct
     4321 ccgcggcccg gtcggccagg atctcctcgg tccgctcctg gcccgccatc gcccagtcct
     4381 cgggcgagac gtggcgcatc gccatctcgc cctcggtcat gatccgtttg aggacgggtc
     4441 ccgccaggct gtcggccacc accatgtaga actcgccggt gccgccgtcc ggccccgcgg
     4501 cggcgatgcg gtcggcgatc ccgccgatcc gcagcgcctc catggtgtgg gggtactgcc
     4561 cgcgcgcctt catgacgacc gaggtcccag ggtgcttctc cgccaccagc ggcctgacgc
     4621 cgttcaggcc caggaacagc gcggtggtga ggcccgcaag gccgccgccc acgatgagaa
     4681 cgggtacgtg ctcgtccgac acggccactc cttgggtcgc ttgggtcgtt tgggtcgttt
     4741 gggcaggccc gactcgggcc ggccggggcc gccgccgtca cggggccggc gggccgggcg
     4801 cccagtctgc gaagggctgt tggagcaccg atggggttcc ggtgggcgac ttgctcctcc
     4861 agcgcctccc caacagacca tcagcgggcg cctcgaaggt ggcaggggcg gtccgcgcga
     4921 gcgcgccgcc gtcacccatc gagacacagg agccgtcgtg ttcgtcttcg tcaacaaact
     4981 gacactcacc ggagcggccg aggacctgga acgcgtctac gcccatgtcg ccgagttcat
     5041 gcgcacccgt ccgggcctcg tccgctacca gctcgtccgc tcgcagggcg acccgtcggt
     5101 gtacttcaac gtcgccgagt ggacggacca ggcctcgttc gaacaggcgc tgaaggaacc
     5161 ggagttccgc agccggctca aggctctggg caccgtcgtc aagggcgagc cgcacctgtc
     5221 cgacctggtc gagtccggcg tcggggaggc ctgatccggt gtccggaccc ctcaagatca
     5281 gcaacccggt cgacggtgag acctactccc ggatcacgca gttctacgcc catcagatgc
     5341 agctcctcga cgagcgggcg gccgaggaat gggccgacgg cttcaccgag gacggcgtct
     5401 tcgcgcagaa cgtgaagccg gagccctgga cgggccgtgc cgtcatcgcc gagcggatgc
     5461 gcgccggaat ggaccggctg gccaagaagg acgtacagcg gcggcactgg ttcggcatgg
     5521 tcgccaccga gcggcaggac gcggagacgg tcctgacccg ctactacgcc atggtcttcg
     5581 agaccccgcg gggcggccgt gccgccacct acctcagcac caccggcgag gacgtcctgg
     5641 tcctccagga cggccagtgg cgggtcaagc accgcctcat cacccacgac ggcacctgag
     5701 ccggccgacg gcacagcgaa gaagagaagg ttgtgagcat gagcaagctg acacgcgagc
     5761 gtgtggccgc ggcgtacgcg tcactggtga ccggggaccg tgagcagatc ctccagtact
     5821 ggtcgccgga cgtgcgcttc cagatgccgg gcaaccacca gtactccggc tggttcgtcg
     5881 gcctggacga ctacctggcg aagatgggca agctgatggc cgccaccggt ggccgcatct
     5941 cctccgagac gctcgacgtc ctcatcgacg aggaggccgg cgtgtcgatc gacgtgtacc
     6001 gcctcgacgg ctaccgcgag cacgccaagg aggacgcgac ctccccgtac gagcggctgc
     6061 aggtcgaagg tgtgcacatg ctgcgctggg aggacggccg gatcgtcgag ggccgcagcg
     6121 ccctgttcgc cgacggtgtc acccagggaa atctgtggtg gtcaccggtc ggcgccgacg
     6181 gcgagcgcta cgagtactga tccttcgcgg ggccgtccgg gcgggtgtgc ccggcacggc
     6241 ctcgcgcatc ccagtgagga agtgcagcca tgactgagcc agcacagggc ctgctccagg
     6301 accgggccgt ggtgatcacc gggggcggga cgggaatcgg ccgggcggcc gcacacgcct
     6361 tcgccgccga aggcgcccgc gtcctggtgg tcggccgcag ggccggcgtg ctcgccgaga
     6421 cggccggtgg ccacgagggc atccggacgt ttcgcgccga cctggcggac ccgggggcgg
     6481 cacgtgccgt ggtggaggcg gccggggacg cactcggcgg catcgacgtc ctggtcaaca
     6541 acgccgtcac gatgcggtcc gcgccgctgg gacacatcga ccgggacaac gcccgtgacc
     6601 aggtggccac caacctgctc gggccgctgt tcctcaccca ggaggcgctg cccgcgctgg
     6661 aggccgcgaa ggggctcgtc gtcaacgtca ccacggccgg caaccagcgc ggctgggccg
     6721 ggcattcggt ctacggcgcg accaaggcgg gcctcgactt cctcacccgt acctgggccc
     6781 tcgaactcgc ccccaggggg atcagggtcg cgggcatcgc ccccggtccg atcgagacgc
     6841 cgatcgcgga gcacgccggg ctcgacgccg agggcatcgc gcggctgcgc gcacggcagc
     6901 gcgaccgggt gccgctcggg cgcgtgggcc ggccggagga ggtggcctgg tggatggtgg
     6961 ccctcgcccg ccccgaggcg tccttcgcca ccggtctcgt cctgcccgtg gacggcggcg
     7021 cgagcgtcgt cttctgaccg ccctctcgac tgccagcaca agggagccag catggaattc
     7081 ggcatcaact tctttcccac cgtgggaccg gacgacaagg acgcggcgga ctacttcgag
     7141 gacagcctga acctggtcgt gctcgccgag gaactcgggt ttgaccacgt caagacggtg
     7201 gagcactact tcttcaagta cggcggctac agcccggacc cggtcacgtt cctcgccgcc
     7261 gcggcggccc gcaccagccg catcaagctg gtgaccggtg ccgtcattcc ggcgttcacg
     7321 catccgctga agctggccgg caagctggcc atgctcgaca acatctcccg gggccggctc
     7381 caggtcggct tcggacgggc cttcctgccc gacgagttcg acgccttcgg catcgacatg
     7441 gacgagagcc gggcacgctt cgaggagggc gtcagggcct gccgcaagct gtggagcgag
     7501 gaggacgtcg tctgggacgg cgccttccac tccttcggcc cggtcaccct gctgccgcgg
     7561 ccccaccagc gcccgcatcc gccgatcctg gtggcgacgg cgaagaccgc gtcctcgtgc
     7621 gagcaggccg gccgggacgg ccacggcctg atgatggtcc cctcgatcaa caagcgcgag
     7681 accgtgcagg acatgctcgc cctctaccgc aaggcgtggg cggaggcggg ccatcccgga
     7741 cagggcgagg tccacatgag ctacaactgc tacctcagtg aggacgccgc cgaggccagg
     7801 gccaagggca aggagtactc ccggcgttcc aacgaggtca tgcgggacgc ggtggccgcc
     7861 tggggcgagc ggcgcagcga ggtgtacgcc gggtacgaga aggtcgtgga gaacatcgca
     7921 cgggcggact tcgaccggtc actggccgac aacaaggtgc tggtcggcac tcccgaggag
     7981 gtcaccgaac ggctccggac gatccgtgag tggttcgggg acatctccgt cagcctccag
     8041 gtgatctccg gcaaccccag ccacgaggag tccgcgcgca gcatgcggct cttcgccgaa
     8101 caggtcgtcc cgcacttccg caccgctccg gccgccgccg gctgaccgga cgcggtccgc
     8161 gggaaccgac gagggcggcg cctcccacac cgggaggcgc cgccctcgtc ggctgcccgg
     8221 gtccgtgccc gagtcgtcag cggggccgga cgacgtcacg caccagcgtc gacgtcacac
     8281 gcgccgccac ggcggccacg gtcagcgccg gcggaacacc ggtgccgggc agcagcgaac
     8341 cgtccaccac gtagaggccg cggtagccgt ccacccggcc cgcgtcgtcg gtcaccgtgc
     8401 cgagcggcac gccgccgacc acgttgccgc cggtggtgcc gatccggctg aacgccgtac
     8461 ggctgcccgg gttggcctcg ttcagccggt ccagggtgtg gccgatggcc gactgcgcgc
     8521 gttccagggc cgggtcgtcg gcaggccagt gcaggacgac gtcgtccgtg gccgggtcgt
     8581 gccggaaggc gcccagcgcg ggtgccggca cggccccgat ggtggtggtc cagccctccc
     8641 cctccggggc ctgcggccag gggaagttga gcagcgacac cggcccgagc gggttgtcct
     8701 cccagtcccg cgcgaggatc gcggcggggc cgccctgccg ggcgttgttc tcgtccatgc
     8761 cggtacgggc cgtgatcacc tcgctgttgc cgacgcgggt gccgagcgcg gcgtgcaggg
     8821 cgggcagcgc gccgctctcc ctggcgcgca gcagcagccg gttggtgccc agggtgccgg
     8881 cggacagcac cagccgcccg gcggtgatcc ggtggcggcg cagcacctcg ccccgctcgt
     8941 cgatcgactc gtagtcgacg tggtatccgc tcccgccttc ggccgggcgt acggcggtca
     9001 ccacgctgag cggccgcacg tcgatgtgcc ccgacgcctc ggcgcgggcc agcaccgtac
     9061 ggtcgaggct gcgctgggcg ccgctgttga cgccgaagac gttcagcccg tcgatctggg
     9121 accgcacccg ggtgccggcc atctcctcgc ggaccacgtc ccagtccacg gcgaggtcga
     9181 ccttgtccca cgggatcccg gccttgtcga gctggtcggc gaacgagcgg gccgaccggt
     9241 agaactcgga gtggtagacg tcgtccggga tcggtgcgca gccgatcagt tcgcgtgcct
     9301 cggggtacca ccgctcgtgc atctcgcggt ggtccaggac gtcgcccagg gtccgccgga
     9361 acagctcggc cgggggctcg cacatggtgc cgttggtcgc cagcgaggcg ccgcccaccc
     9421 ccgtaccggc gagcacgttc atgccgctgc cctcgacgaa ctccaggacg ccggtgtgga
     9481 cgtcgagctt cgcgtcggtg aggggcgacg tctcgctgag ccatgcggca cgcccgtcgg
     9541 gcgcggcctg tgtcgcgaaa gtgtcgcccg cgtcgtcgac gggccagcgg cgcccccgtt
     9601 ccagcagaac ggcgtcgacc cccgcttccg ccagcctcag ggcggcgatc gatcctccat
     9661 agccgctgcc gacgatcacc acgtcggcgc ggtgctgctg cctctccact gagcggcctc
     9721 cctgccttct ccgtctggcc tgtccgaact tcgtccggcc tgtcgaacac ggaccgcgcc
     9781 gggcccgtca accccaacgg ccgccggacg acggttggtg accgtggtcc ggcggccgtg
     9841 tgcggtgggc gcgcgctggg ccgaagggaa cgggtcgcgt tccgtccgcc gtgcttccca
     9901 gtgtggaaac gggggctggg agtcggatgg gggcccgctg gagaggcgcg gggcggctct
     9961 ctccccgccg agaccgagcc tccagggcgc ggtgcgagag tgcggccgtc gcaccgttcc
    10021 cgttccgccc cgaggaggca gccgtgcaac cgaccccttc gcccccgtcc ccgtccccgt
    10081 ccccggctcc ccgtggagtc gccctgctgt tccccgggca gggggcccaa cagcacctga
    10141 tggctgcggg gttgtaccac gcccatccgc cgttccgccg cctcgtggac gaggtgttcg
    10201 aggtgtgggg cgcggagggc gccgcgctgc gcgccgactg gctgtccggc tccccggacg
    10261 tggacctgga cggggtgcac cgggcccagc ccctgctgtt cgccgtcgac tgggcgctgg
    10321 gccgcctggt gctcgactgg ggggtgcgcc ccgcggccct gctcggtcac agcgtcggcg
    10381 aggtggcggc ggcgaccctg gccggtgtct tcaccctgga ggaggcggcc gggctgatgg
    10441 ccgaccgggt ggcgcacatc gcctccgcac cggccggcgg catgctggcc gtgcacgcgg
    10501 cggccgacga catggcgccc tacctgcacg ccgacgtggt cgtcggcgcc gtcaacgcac
    10561 cgcgccaggt gatcctggcc ggctccgagc agccgctcgc cgagtcggag gcgcggctgc
    10621 gcgcggcggg gttcacctgc cgccgcaccc gtgccctgag cccgttccac agtccggccc
    10681 tcgccccggc cgcgcgggcg gcgctgcccg cgctgtcccg gctgccgctg cgggccccgc
    10741 ggctggcgct gcactcggcg tacacgggag gaccgctctc cccggacgag gcgcgggatg
    10801 cgcggttctg ggccgggcag ccggccgccc ccgtgctctt cggccccacg ctcgacgcgc
    10861 tgctgggcac cggcgagctg ctgctcctcg aggccgggcc cgggcagggg ctcaccgccc
    10921 tcgccaagcg gcatccggcg gtcggcaccg gccgctccac cgctcgggcg atgctgccgg
    10981 cccgcgcccg gggcgacgcg tcggatctgc ggacgctgcg tacggcggtc gaggcgctgg
    11041 cggcggaggg gtggccggtg cccgaccggc tgccggttgc ggcaccggcg agcacgccct
    11101 gaacgggccc agcacgcaac cagaggtcca ccatcccgcc accaggcagg gctgcgagcg
    11161 tgacaggccg gggccggtca ccggaccccg ccgactgtga gtgaggatgt catggagcgt
    11221 cgcatcgtca ttacggggat cggtgcagtg gcccccggca agccgggcgc caaggagtac
    11281 tgggagctga tctcgaacgg ccgcacggcc acgcgtacga tctcttcctt cgatcccgcg
    11341 ccctaccggt cccgggtcgc cgccgaatgc gacttcgacc ccttggccgc cggcctcggc
    11401 cggcaggagg tccggcgcat ggaccgggcc acccagttcg ccgtcgccgc cgcccgcgag
    11461 gccgtcgccg acagcgggct ggacctgccc gcggacgacc ccgccgccgt cggggtgtcc
    11521 ctcggcaacg ccgtgggctg cacgacgagc atggaggagg agtacacggt cctcagcaac
    11581 gagggatccg actggctggt cgaccaccac tacgccgtgc cgcacctcta cgaccacttc
    11641 gtaccgagtt ccatcgcggt ggaactggcg cggctggtgg gggcgcaggg ccccgtggcg
    11701 ctcgtctcgg acggctgcac ctcgggcctc gacgcgatcg gccacgccac ggacctgatc
    11761 cgcgagggca gtgccgacgt cgtgatcagc ggcggcaccg acgctccgat ctcgccgatc
    11821 accctggcct gtttcgacgc catcaaggcg accactcccc gcaacgacga cccggagcac
    11881 gcctcgcgcc cgttcgacgc gacgcgcaac gggctcgtcc tgggcgaagg ggccgcggtg
    11941 ctggtgctgg aggagctgga gcacgccagg cggcgcgggg cccggatcta cgccgaggtc
    12001 gcgggggtcg gcacgcgctg caacgcctac cacatgaccg ggctgcggtc cgacggggcg
    12061 gagatggccg acgccatcac gcacgccctc gccgaggccc gcctggcgcc cgagtcgatc
    12121 gactacgtca acgcgcacgg gtcgagcacc aagcagaacg accggcacga gaccgccgcc
    12181 ttcaagaccg cactggggcg gcacgcctac gacgtcccgg tcagctcggt gaagtcgatg
    12241 atcgggcact cgctgggcgc gatcggcgcg ctggagctgg tcgcctgcgt gctcgccatg
    12301 cgcgacgggc tggtcccgcc gacggccaat ctccacgagc ccgacccggt ctgcgacctg
    12361 gactacgtgc cgctgcgggc cagggaggca gaggtcgaca acgtgctgag cgtcggcagc
    12421 ggcttcggcg gcttccagac ggccatcgtc ctggcccgtc ccgagcgggc ggcggcatga
    12481 gcgccggcgg cacggtacag gcggtggtca ccggcgtcgg cgtggccgcg cccaacggga
    12541 tgggcaccga ggcgtactgg gcggcgacgc tggccggacg cagcggcatc gccccgacga
    12601 cccgctacga cgcgagcggg tatccgctgc ggctggccgg ggaggtgcgg gacttcgacc
    12661 ccggggagca catcccgagc cggctcctcc cgagaccggc tctcctccgg ccgcgaggcg
    12721 ctgcgcgaca gcgcgctcga ccacccggca ccacggctct ccgggttcga gtgtgcacgc
    12781 gggcgggcgg ttcgtcagcg cgtaccagtc cttcgcctgg ttctacgccg tgaacaccgg
    12841 ccaggtctcc atccggcacg gcctgcgggg ctccagcagc accgtggtga ccgacgcggc
    12901 cggcggcctc gacgcactgg gcaacgcccg gcggcagatc cgcaagggga ccaccgcgat
    12961 gctcgccggg agcgtcgacg gtgccctgtg tccgctcggc ctcgccggac agctcagctc
    13021 cggcgccatg agcaccggca gccgtgccga ccgcgcgttc ctgcccttcg ccgacggcgc
    13081 cggtggccag gtgccgggcg agggaggcgc gttcctggtc ctggaggacg cggtgagcgc
    13141 acggcggcgc ggcgcccgca gctacggcga actcgcgggc tacgcggcga cgttcgaccc
    13201 cgcccccgtc ccgtcggacc aggccggcga ggggctggtg cgggcgatcc ggcgggcttt
    13261 gcgggacgcc ggtacggccc ccgaggacgt ggacgtcgtg ttcgcggacg ccgccggtgt
    13321 gcccgagctc gaccgggcgg agtcccgtgc gctcggcgag gtgttcgggc cgggcggtgt
    13381 cccggtgacg gcgcccaaga gcatgacggg ccgtctcttc gcgggcgggg cgtcactgga
    13441 cctggcgacc gcgctgctcg ccctgcggga cggagcgatt ccgcacaccg cgaacgtctc
    13501 gcgccccggc cccgggcatc cgatcgacct cgtcaccggg gagccgcgcg aggcggacct
    13561 gcgccgcgca ctggtcgtgg cgcgcggacg cggcggattc aacgccgcgg ccgtcgtccg
    13621 acgcgacacg tgaggaaggg cggacccggc ggtctcgccc ttccgcggac actttcccct
    13681 ttccctttcc ctccgtcccc tttccctcct tccccttccg ctttcacttc cgcttccgct
    13741 tccgcttcca ccaagcccac ctcactccga aaggacaact catgagtgac gccaacacgg
    13801 ccgtgaccga actgagcgtg gaggacctca ccagcatcat gcggtcgtcc gcgggcgagg
    13861 acgagtcggt cgacctcgac ggagacatcc tcgactccgc cttcaccgat ctcggctacg
    13921 actccctcgc actgctggag accgtcgccc gtatatcccg ggaccacggg gtcgagctgg
    13981 gcgacgacgt cctcgacgac gtcgagactc cgcgggacct cctggcggtc gtcaaccggg
    14041 ccatcgccgc ggcgtagttc ccgcggcccg gcacacggca cacgacaccc cgcatccggc
    14101 acccggcagt cgcggagact gccgggtgct tctcgtcagc ggcctgcggc ggccgtgccg
    14161 ccctgcaggg cgcccgtctc ctccaggacc cgcgccagca gccgcgtggc gttgcggtgc
    14221 agcgggaagt ccgtgccggg cggcatgatg ccgctctcct ccagcagccg ggtcacccgc
    14281 gcggtgagca ggcagaaccg gaacgcggcg aagacctcgt agtactccag gtcccgcacg
    14341 gtgtgtccgg tgagccgctc gtagtggcgc accgtctcgg cgcggtcggg cagcccggcg
    14401 agccgggcgg cgccgatgcc ctcgctcagg tgccggtcca ggtgcaggaa ccaggccagg
    14461 tccgactcgg gccgtcccag tccggccatc tcccagtcca gtacggcggc cggggtcacc
    14521 ccgtcgtaga cgatgttgcc gagccgggcg tcgccccaca gcaggcgggg ccggccggat
    14581 tccgcgggcc ggtgcgcgtg cagccaggcc agggccgccg tggcggcctc gttgccgtcg
    14641 gcgccgtaga acggcaggag ttcggtgtac tccgcgagtt gctgcgtgag gtgaccggtg
    14701 ccgtactggg gccggtcgag gaagccgagg ccgagcgcca ccgggtcgag ccggtggacc
    14761 gcggccagca tctccacgcc gccgagccag acggcgcgac ggtcgtgcgg cggcagttcg
    14821 gccagccagc cctcccggtg gtacgaggga aggtcggcgg gcacctgtcc ctcgatccgg
    14881 cgcatcacca ggaacggcgc cccgagtacg gatgctcccg gctcgtgccc cagcaggggg
    14941 gccacgggga cgtcggtgcc gtcgagcgcc tccagcagtc tcacctgctc tgtccagcgg
    15001 tcgtcgggga ggacgcggtg cccggtgggg gccacccgca ccgccagggg ttcccggcgg
    15061 gtcgccccgt cctcggtcca ctcggcgtcg cacagcagga tctctccgga gaatcccgcg
    15121 gcaccgggca ccccgaccgg accgatcctc acctcgccgg ccccgggcgt gcgggcctcg
    15181 aaccacccgg ccaacgccag gcgggtctct tcggaatcgc gctgcacggg tacgggcacg
    15241 ggcttcctcc ttcgctacgg caggctccgc ccggaccgcg gtgtccggcc ggtccgggcg
    15301 gagcccgagt ctcgccggag cccctggctc ccgggtccag ggccgctgga ggcgtgcccg
    15361 gcaagtcccg cgggccgcgc gtctccagcc gggctccctc gccccgccat ctcgtcgaag
    15421 cagcatcgag ttcccggatt ccgcgggctc ttctcgccga ccggaacaca ggaggagcaa
    15481 tgcagttgca gggcaggacc gccgtggtca ccggcggtac acgcggcctg ggcagggccg
    15541 tcgcgcaggc gctggccgac gcgggtgcgg tcgtggtcgc cgcggccagg gacgtgcagg
    15601 ccgcgcagcc ggacccggtg gccgggggcg gccggatcgt ccaggtgaag gccgacgtca
    15661 cggttcccca gtcggtggag gagctgatgc gtacggccca cgagcggtac ggcggtccgc
    15721 acatcgtggt cgccaacgcc ggggtgagca ggcccggtcc ggtgtcggtg ctgtccggcg
    15781 aggactggga caccgtgatc ggcaccaatc tgacgggcgt cttccacacg gtcagggcgg
    15841 cggtgccgtt cctccaggag gccgggccgg ggcgggtcat caccgtgtcc tcgctgctcg
    15901 ggcggcgagc catgccgggc gccgccgcgt actgcgcctc caaggcggcc gtcgagcggt
    15961 tcacggaggt ctgtgcgctg gagctggcgc ccaaggacat cacggtgaac tgcctgtccc
    16021 ccggtttcat cgaggagggg cagggacgcg ccctgatggc caacgaggtc ctctggccgc
    16081 ggctgcgcga cacgctggcc gcggggcggc cggggacggg agccgaggtg gcccgggccg
    16141 cagtgttcct ggcctccgcg gagagcagct acgtcaacgg ggcggtgctg ccggtcgacg
    16201 gcggcgtgcg ctggtgaacg gcgcctcggg ttcccggtgt tcccgtcttc cccggcaccc
    16261 cctcttcccc cggaatccca tcgcgacgac agccacggag gcgacgacca ggtgctcacg
    16321 tggccggcac tcccgcggac ggcacggcgg ccggtccggt ggagcgaacc ccggtcgggc
    16381 cgtcgccctg tctccctgct cggcatgctg ccgccgggtt cacggctggt ttccccggca
    16441 cggttccgga cggcgtcgag tggaccgacg ccgcggccgt ccccgtggcc ggcctcaccg
    16501 cgctgtacgc cctgcgcaac gccgggtcgc tcctgggccg ccgggttctg gtcacgggcg
    16561 ccagcggcgg agtcggccgg atcgccgtcc agctcgcccg ggcgtccgga gcggaggtgt
    16621 ccgcctgggc cggttcggcc gagcggctga agggcctggc ggagctgggt gccgccgagg
    16681 ccgccaccta cgaggcgggg cccggggtga cgcagccggt gcacgtcctg gtggacagcg
    16741 tcggcggcga ggtgttccgc agcgcgtacc aactggtcgg gcagcgcggc gtcgtggtct
    16801 gctacggcaa caccacgcgc tcggacctct ccctgccctt cgactggggc catgcccgcc
    16861 ccggtgtccg gatccggtat ctccacctgt tcgacgagat gccgcgcagg cctgtcgggg
    16921 aggatctcgg ggtgctgctg cggctcgtcg ccgagggcgc cctggacccg caggtcacgc
    16981 tcgtcggcga ctggtcggac ccggatcccg tgctgcgcgg cgtcggtgac cgacaggtca
    17041 acggcaaggc tgtgctggtg ttctgacgtc ctgatcggtt ctgcggttcg gagccgtcgc
    17101 ggtgtcccag gcggttccgg tgatccgggc ggttcggagc cgtcgcggtg tcccgggcgg
    17161 ttccggtgat ccgggagttc ccatgttgcg ggcggtccgg aacaggggcc ccgccggggc
    17221 ggggtgagaa ggcggaccgg tgccggacgc ggcgggggat gtccacgtcc ggcaccggag
    17281 tcttaccggg gtcccgccct caggaggcgg cggccccgcc cttccagggc gagttgcgct
    17341 cgtacctggg ccgccacact ccccggtaca ccaggcgcag cggggccggg acccggtcga
    17401 gcacgttgcg tcgttcgtcc tccggcaccc cgtcgagcag ccaggggaag aacgtcgccg
    17461 cgcccttgat gccgacctgg gtgcgctgct ccgtcacgaa ggcgtcccac tcggccgccg
    17521 acagctcgct ctccaccagg ggcagggcct gggcctcctc gtggtcgagg tggtcgagca
    17581 gacaggcggc gacgtcctcc atgaggtccg gaagcgcccg ttcaccgccc tgccggccga
    17641 gcgccgcgtc gatcttctcc acggccgtgt cgagctgtgc gtgctcgacc tccatggccc
    17701 ggagcatctc caacgcctcc ttctgcccgg ccagtttggt gcgcagcacg ggccacaggg
    17761 agtggtcctc ggcgaggtgg tggatcgtca ggtaggtctt gaaacgctgc catccctgcc
    17821 ggaaggccgc gaggtcgtcg tgctgcgcct cctccagcag ccgcagatcc cgccggaagg
    17881 cgtggtggat cgcgtacatc atcgtcaggt cgacggctgg tgcgctgccg gtctgcgctc
    17941 gggcgttcac tgcggcctcc tgcgggtcga gtgtcggtac gggggttcgg gcgagggccg
    18001 gacgagggtc cggcgggtca gatcacgacc cccatctcgg cgtcctccgc gtccttggag
    18061 gagacccgga gcaccaggac ggcgaggacg aacgcgccga gcaggacgaa gccggccacc
    18121 atgaacgccg tgccgtagcc ctgcgcgagc gagtcgaaca ccgccttgcg gacctccggc
    18181 ggcatgttcg ccgcgtcggc gggtccgtag ccctcggccg attcggcggc ggccgctccc
    18241 atcagctcgg tgagccggtc cttggtggcg ctgatcgcga ccgtcccgag ggccgcgagg
    18301 cccagtgcgg caccgacctg ctgaccggcg ttgaggaggg cggaggagac acccgcctgg
    18361 gccttgcgca cccctgccac cgccgcgagg gtgagcggca cgaagcacag gcccacgctg
    18421 catccggcga ggctcagcgg gccgagcaga tcgccgctgt agctgccgtt ctcgctgagc
    18481 tgcgagaacc agaagaaggc gacggccgcc aggagggtgc cggcgccgag caggatccgc
    18541 gggccgacgc gcccgaccac ctggctgctg atcgtcgcga agaccgccgc tcccacggcg
    18601 aacggcagga aggcgaagcc ggtcttgagc gggctgaagc cgagcacgat ctgcatgaac
    18661 agggtgagga agtagaagag ggcgatcatg ccggcaccga gcgccagcat gatcgcgtac
    18721 gcaccggacc ggttgcggtt gcggaagatg ctcggcggca tgagcgggga gtccgtgcgg
    18781 aactcgatga agaggaagac ggcgagcagc gcggcgccga cggcgagcgg caggaccgtg
    18841 cccgcactgc cccagtcgtc ggtggccgcg tggatcagcc cgtacaccac gagcgacatg
    18901 ccgacggtgg aggtgacggc gcccggcagg tcgaggcgcc gccccccggt ggtgacgcgc
    18961 tcggcgggga acgccttgac cgcggccagc agcagcagaa caccgatggg aacgttgacg
    19021 aacagcaccc agcgccagct cagcgcgtcg gtgaagacgc cgcccagcac gttgccgagc
    19081 gcgccgcccg cgccgcccat ggccgcgtag atgcccatgg ccttgttgcg ttcggcgccc
    19141 tcggagaacg tgctggcgat cagcgccaga gcggcgggtg cgatcagcgc accggcgacg
    19201 ccctgcacgg cccgggcgcc gatcagccag ccctggttgg tcgcgaggcc gccgagcagc
    19261 gacgacaccg tcagcagtcc gatgccgaag aggagcgtgc ggcgctgacc gtacatgtcc
    19321 gcgatccgcc cgccgagcag cagcagtccg ccgaaggcga gcgcgtaggc gttgaccacc
    19381 cactccaggt tggtcgcgga gaagtcgaga gccgactgga tggacggcag cgccacgttg
    19441 acgatcgaca cgtcgagcac gaccatcagc tgggcgaccg cgatggcggt cagcgccaga
    19501 cccttgcggg agggtgagcc ggtcgcggcg ccggccggtg gggaagcgga cggggatgcg
    19561 tgagcctgcc ccagggactg ttcggacacc aggaatctcc tgccgaggtg cggtgggaat
    19621 gggggggggt gtatggacag cgacagctcg tcctctggaa acggaacaac tcgccccaca
    19681 actacggaac agtatgtccc gcacttctct ccggtgcaag ctgttccaca cggcggggac
    19741 gaccgctcct gcgggcctcc tgtccgcggc catccgccca cctccggccc tccagcggaa
    19801 cggcagatcg tgagggggcg ctcgcgcaac cggaccccgc ccgccccggg aaggaacgcc
    19861 cgaatgaccc agccgtcggc cacgccccgc accggcaccc cgcccgcgca ggaccctccc
    19921 cgtctggaag agctcgcacc gggcgtccac gcctacgtcc agccggacgg gggctggtgc
    19981 ctgaacaacg ccggggtgct gatcggagac ggcgcggtgg ccgtggtgga caccgccgcc
    20041 accgaacggc gggcccgcgc cctgcgcgcg gccgtcgcct cccgtacgcc gctggaggtg
    20101 ggcacgatcg tcaccaccca ccatcacggg gaccaccact tcggcaactc ggtggtcgcc
    20161 ccgcacgcca ccgtggtgtc gcacgaggtg acccggaacg aaatggcccg ccgcggcctc
    20221 gcgatgcggg aggtctggcc ggacacggac tggggcgacc tccgcctcgc gctgcccacc
    20281 ctgacgttcc gggaccgcgc cacactccat gtcgggggcc tgaccgccga gttgatccac
    20341 gtgggccccg cacacaccac cagtgacatc gtggtctggc tccccgaaca gcgcgtcctg
    20401 ttcgcgggtg acgtcctgct gcccggctgc acgcccttcg tcctcatggg ctccctgagc
    20461 ggcaccctgg aggccatcac gaggctgcgc gccctggacc cggccgtcgt cgtgggcgga
    20521 cacgggccgg tcgccggccc cgaggtgctc gacgacaccc gcgactacct gctgtgggtg
    20581 cgcgacaccg cccgggcggg cctggccgcc ggggcctcac cgctgcaggc cgcgcgcgac
    20641 gccggcctcg gcccgtacgc cggactccgt gactccgagc gcctggtggc caatctgcac
    20701 cgcgcctacg tcgaggagtc gtcgcggccc cgggacaccg agatccggtc ggccccggtc
    20761 ttcgcggaga tggcggagtt caacgggggc cgccccgtcg cctgtcacgc ctgaccgtcg
    20821 ccgctgcccg gtcacgcctg acccgtcacg cacacgtggg ccatgtccaa gtgcgcgggc
    20881 gcacgggcgc gggcgacggc ccacgacgca ctgcatccgc accggccggg ccctgggtac
    20941 gggcccggcc ggtgcggatg cagtggtgca caggtgccga tgcgcgggtg ccggccccgg
    21001 ccgggccacc ggccgggtgt gtccggcgcc gcggtcagcg ggcggggctc ggttcggtga
    21061 actccttggc gtgccgcagc gtcgccagac tgttggcacc cagcgtctcc cgtatgaagg
    21121 tgcgcgcgcc ggccacggtg gtgtccgggc cgagcagggt gaccgaggac gggttgatca
    21181 cgacggtgtg gcgcgccacg gccgtcgtgc ccccgtccgc ctcctccagc agccactcgc
    21241 cgacgtgcgc ggtgagcagc ggcggcaccc tcagctgctt gtagacgatc ctcgagggcc
    21301 cgaggctcac ccgtaccgac tcggtggtgt gccgggagcc gtccttggcc agggtgtcca
    21361 tctcgaggac ctggatgtcg tcctccggct ccgacagctt cacccgggcc acgtgcggca
    21421 gccggtcctg ccactgctcg ccgcgccaca ggaacgcgtg cacgtccgca atcggcgcct
    21481 cgatgcgcac ccggtcctcg aaggtgcaca gcaactcgcc cagttcaccg gcggattcgg
    21541 cggtggcctt catccggctc agctcggcct cgctgttgcg gtccagcgcc cggttgatcc
    21601 actcgacgtt cccggggtcg tcgtcctgcg cggtgaagtc gtggaggagg acgacctcgc
    21661 agcggccgtc ggacagcgcg cgtatctgcc accggccgcc catcgacgtc gccggagccg
    21721 tggtccgttc ctgccggaag gcgaccgtga gcgcctccgg gtcgagccac cgcctcgact
    21781 gccagtgctt cacttcgtcg ttggccgtgg cccagatgcg cagggcctcc tcgccgtcgc
    21841 cgagcggcgt ccgctcgacg tggaccgacg gggggaagac ccgcggccag tcggcggcgt
    21901 ccgcgacgat gtcgtacacc gtgcgcgccg gagcgtcgac ggtgatcgtg tgccgagcgt
    21961 gatgcgtcac tgccatggtg ggtccggctc tccttcggta gggctgggcg gggttgcggc
    22021 cgcccgtacg cacacgggtc gtccgcgggc gcgtcagtag ttgccgaggc cgccgcagac
    22081 gttgatggcc tgcgcggtga cgggggcggc ggcgggaccg gccaggtagg cgaccagggc
    22141 ggcgacttcc ccgggggcgg tgtagcggcc cagcgggatc ttggcctcga accgtttgag
    22201 cacctcttcc tcggcgacct cccagtggcc cgcgtaccct tcgcgcaccc tcttggccat
    22261 gggggtctcc acgtagccgg ggcagacggc gttgacggtg atcccggtct tggccagctc
    22321 cagtccgagc gacttggtga agccgacgac cgcgtgcttt gaggcgctgt acggcgctcc
    22381 gagcatcacg ccctgcttgc cgcccgtcga ggcgatgttg atgatccgcc cgacggactt
    22441 ggctgccatg ccgcccgcgt tgagcacttc gcgggtgacg cggaagacgc tggtcaggtt
    22501 ggtctcgacg acgtcgttcc agagttcgtc ggtgatctgg gcggtcactc cgccgccgct
    22561 gcggcccgcg ttgttgacga ggatgtcgat ggggccgaaa cgctcgacgg ccgtcgcgac
    22621 cgaccgggcg acgtcgtcgc cggaccgtac gtcggcggcg gtgccgtcga ccgtgatgcc
    22681 tgcctcggtc agctccttca ccgtcgccgt gacgtcctcg gcgttgcgtg cggtgatgaa
    22741 gaccttgatg ccggccccgc ccagggtctc ggccaccgca cggccgatgc cccgcgtggc
    22801 acccgtgacg aaagcgaccc gggactcccc gctctgcggc tccgtcgtca tgacgttttc
    22861 ctcctgacct gctgacactg gctctacccg gccgagcctg gcggtcgcgc ctggaggatg
    22921 actgaagacc cgggagtggg gacggctcgc ggctcgtccg ccgccgttgc ggatctgccg
    22981 cgcaccatgt ggcggtgacc ggctctccag ggccgggtgc cagggtctgc cggaggacga
    23041 ctcgaccggg aggacaccat gggcacgact tcgcccgccc gcgaccacac cgacgcagcg
    23101 gtgcccgtca gttcggggac gctccgcggt gtgctgcgcg aggttccgac agccgtcacc
    23161 gtggtcacgg cgacaacaga gggcgggccg gccgggctga ccgtggggtc gttcgtgtcg
    23221 gtgtcgctgg atccgccgct gatcggcatc ttcgtcgacg agaagtcgtc gagctggccc
    23281 gagatgaggc gttcggccac cttcaccgtc aacgtcctct cgggcgacca gcaggagctg
    23341 tgcgcccggt tcgcgagcag cggcggcgac aagttcgcgg ggctgacgcc ggcgacgtct
    23401 ccgctgggca atcccctgct ccccggcgtc gccgcgtggc tcgactgccg ggtcgaggag
    23461 atacgaaagc tcggcgacca ccacttcgcc ctggcgcgcg tggccggtct ggggcggccg
    23521 gccacggcgg gctccacatc gatcgtcttc caccgcggcg ccctgcacgc ggtcccgtga
    23581 gctgcgcagc ggcgtgcccg cgccagccgt ccgccgctgc tgccactgcc gccactgccg
    23641 ccactgccgc cactgccagg cgtcgtaccg ccggcgtcac cgctgtcggc gtcaccaccg
    23701 aaacggctgc ccgcgccggc ggaccggagc gggatcgcgt ccggtccgcc ggcgcgggcg
    23761 gctgtcactc ctgcgcgggg cggccttcgc ggtgccgtcg gcgcggtctc agcacacgct
    23821 gcggccggag ggccgcc
//
