LOCUS       BGC0002507             18330 bp    DNA     linear   PLN 26-SEP-2020
DEFINITION  Chrysosporium merdarium strain ATCC 74009 sporandol biosynthetic
            gene cluster, partial sequence.
ACCESSION   BGC0002507
VERSION     BGC0002507
KEYWORDS    .
SOURCE      Chrysosporium merdarium
  ORGANISM  Chrysosporium merdarium
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Onygenales; Onygenaceae;
            Chrysosporium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:52:14
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18330
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..18330
                     /culture_collection="ATCC:74009"
                     /db_xref="taxon:108922"
                     /mol_type="genomic DNA"
                     /organism="Chrysosporium merdarium"
                     /strain="ATCC 74009"
     misc_feature    <1..>18330
                     /note="sporandol biosynthetic gene cluster"
     subregion       1..18330
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18330
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<372..>5808)
                     /gene="spoP"
     mRNA            complement(join(<372..5066,5128..5428,5516..>5808))
                     /gene="spoP"
                     /product="polyketide synthase"
     CDS             complement(join(372..5066,5128..5428,5516..5808))
                     /NRPS_PKS="Domain: SAT (19-247). E-value: 2.7e-44. Score:
                     143.4. Matches aSDomain: nrpspksdomains_spoP_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (385-814). E-value:
                     2.6e-141. Score: 463.2. Matches aSDomain:
                     nrpspksdomains_spoP_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (914-1204). E-value: 4.1e-71.
                     Score: 231.6. Matches aSDomain:
                     nrpspksdomains_spoP_PKS_AT.1"
                     /NRPS_PKS="Domain: PT (1296-1614). E-value: 5e-104. Score:
                     339.9. Matches aSDomain: nrpspksdomains_spoP_PT.1"
                     /NRPS_PKS="Domain: PP-binding (1697-1757). E-value:
                     1.2e-12. Score: 40.0. Matches aSDomain:
                     nrpspksdomains_spoP_PP-binding.1"
                     /codon_start=1
                     /gene="spoP"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 187.2; E-value:
                     8.5e-57)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="QNT61260.1"
                     /sec_met_domain="itr_KS (E-value: 3.5e-157, bitscore:
                     512.1, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.4e-72, bitscore: 231.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-13, bitscore:
                     40.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLVHFTNQLPSDHLAIFRRLRTQSKANDGAILRIFLQKATQTLR
                     EEIRLLPVEQKAIFPPFNNILDLAEAQSLRRGYLGEAIDGVLLNVMHLSLFIRYHELHP
                     QEFTYGRVSACVTVQGYARLAGAAVLVSPTLADLPMAGAEAVRMAIRLGTVMEETSRGL
                     EAREPESTPESWAAAIADMDADTVQEELDAFNTSTHNPIPSQIFISVVGIGSTVISGPP
                     TKINQLFQVSGKLRYSNFTILPIYGGLGHAPHLYNKSHVAKVIETVTTKVANRPLVDTI
                     SIFSSADGRRISGDRALDAFTKVVSEVLLDTIRWQKVFDGVVGALSSAEDAVFNVHYFN
                     TSPLIEQLMTEVRSRLPASKIKTIDLVDCAVAAPNEETNRIADDRIAIVGMSCRFPGGA
                     NDTQLFWNLLEEGRDVHTKVPADRYDVETHTDPTGKTRNTSLTPFGCFVDQPGLFDAGF
                     FNMSPREAAQTDPMARLGIVTAYEALEQSGFVQNRTAASKKERVGTFYGQACDDYREVN
                     SAQEVDTYYITGGCRAFAPGRINYFFKFSGPSFSCDTACSSSLATIQIACTSLLHNEAD
                     TVVAGGMNVLTNVDPYAGLSRGHFLSKTGGCKTWDADADGYCRADGVGSIVMKRLADAE
                     ADNDNILGIILASATNHSADAVSITHPHAATQCELYRNVMGMAGVDPMDVGYVELHGTG
                     TQAGDVTEITSVTGVFAPETPRRESPLHIGAVKGNVGHGEAAAGVMALIKVLLMFQNSH
                     IPRHIGIKNGLNPKFPNLNQLNVAIPFEGVSWPRREDKTRYAFVNNFSAAGGNTALLLQ
                     EPPVPRDRTEDPRSAWAVAVSGKGKVSLKKNLENMIAHLEKNSDISLSDLSYTTTARRL
                     HHSHRISVTGTSLGGILDGLRKELPTVDSRPPVPNSSPSVAFAFSGQGTFYPGIGRELF
                     KTHPFFRTQILQLEATCFTHGYPSFLPAITGEVEDGYVFGPMITQLTIVCVGIALSNTL
                     SALGIKPSVVVGASLGDYPALYTAGVLSASDAIFLAGERALILEAECTPFTSTMLAVRA
                     TEQQIREAANGCHFEVACINGRSDICISATVEEIKDLRAHLESQGFKCHQLNVPFAFHS
                     VQMDPVIEKFERIATGVTFKAPSIPFLSSLLSEAVFDSETINANYMARATRETMNLVGA
                     LEQGQEMGLVDKNTVWIDIGPHPICVPFVKSLTPDVAFAEGTFRRDQDNWATMTDTLAR
                     LYNSGVEVDWNEWHRGFEKDLRLINLPAYGWNEKNYWMQYNGDWMLTKDQAHVSRTASA
                     VEHAQTVPSTLRTSLIHDVMDEVILENSGKVVVRCDLMRPEFYEAVDGHRMNKCAVITS
                     SIHADVAFTLGKYIYSRIKPGSKIPGVNVTKLEVVEAVVARKDKSRPQYIQISATADLS
                     KSCTQLRWYMVDEYGQVADHTFATATVEYGDTETWLNEWAPNAHLVASRIDMLDRLADD
                     GVANRLTRDLVYLLFNNLVDYSEKYRGMHSVVLHGMEATGSVVLAQEVGGTWTVPPHHI
                     DSIIHLAGFIVNGGTSVDNKNNFFVTPGWKSLRFAKPLVPGGRYRTYVRMTPSSEAGYF
                     SGDVYLLEGSEVIGLCGGMTFRQFPRVLLSKFFSPPDSHPKSAPPKHMPAPVLPKKQLA
                     PGKALTPPLSFTSGTPPLEDEPVMGELTPPTEPSSPKMTPIVVDSIGSENQVVKDALVL
                     LAAETAVDISELTGETSFASIGVDSLLSLVLAEKFKEELGVQVPSSLFLECPTLNDLQA
                     WLVDYS"
     aSDomain        complement(390..569)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spoP_PP-binding.1"
                     /evalue="1.20E-12"
                     /label="spoP_PP-binding.1"
                     /locus_tag="spoP"
                     /protein_end="1757"
                     /protein_start="1697"
                     /score="40.0"
                     /tool="antismash"
                     /translation="LAAETAVDISELTGETSFASIGVDSLLSLVLAEKFKEELGVQVPS
                     SLFLECPTLNDLQAW"
     aSModule        complement(390..4505)
                     /complete
                     /domains="nrpspksdomains_spoP_PKS_KS.1"
                     /domains="nrpspksdomains_spoP_PKS_AT.1"
                     /domains="nrpspksdomains_spoP_PT.1"
                     /domains="nrpspksdomains_spoP_PP-binding.1"
                     /iterative
                     /locus_tags="spoP"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(819..1772)
                     /aSDomain="PT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spoP_PT.1"
                     /evalue="5.00E-104"
                     /label="spoP_PT.1"
                     /locus_tag="spoP"
                     /protein_end="1614"
                     /protein_start="1296"
                     /score="339.9"
                     /tool="antismash"
                     /translation="TSLIHDVMDEVILENSGKVVVRCDLMRPEFYEAVDGHRMNKCAVI
                     TSSIHADVAFTLGKYIYSRIKPGSKIPGVNVTKLEVVEAVVARKDKSRPQYIQISATAD
                     LSKSCTQLRWYMVDEYGQVADHTFATATVEYGDTETWLNEWAPNAHLVASRIDMLDRLA
                     DDGVANRLTRDLVYLLFNNLVDYSEKYRGMHSVVLHGMEATGSVVLAQEVGGTWTVPPH
                     HIDSIIHLAGFIVNGGTSVDNKNNFFVTPGWKSLRFAKPLVPGGRYRTYVRMTPSSEAG
                     YFSGDVYLLEGSEVIGLCGGMTFRQFPRVLLSKFFSP"
     aSDomain        complement(2049..2918)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spoP_PKS_AT.1"
                     /evalue="4.10E-71"
                     /label="spoP_PKS_AT.1"
                     /locus_tag="spoP"
                     /protein_end="1204"
                     /protein_start="914"
                     /score="231.6"
                     /tool="antismash"
                     /translation="FSGQGTFYPGIGRELFKTHPFFRTQILQLEATCFTHGYPSFLPAI
                     TGEVEDGYVFGPMITQLTIVCVGIALSNTLSALGIKPSVVVGASLGDYPALYTAGVLSA
                     SDAIFLAGERALILEAECTPFTSTMLAVRATEQQIREAANGCHFEVACINGRSDICISA
                     TVEEIKDLRAHLESQGFKCHQLNVPFAFHSVQMDPVIEKFERIATGVTFKAPSIPFLSS
                     LLSEAVFDSETINANYMARATRETMNLVGALEQGQEMGLVDKNTVWIDIGPHPICVPFV
                     KSLTPDVAF"
     CDS_motif       complement(2571..2684)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spoP_0005"
                     /evalue="6.20E-08"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="spoP"
                     /protein_end="1030"
                     /protein_start="992"
                     /score="24.6"
                     /tool="antismash"
                     /translation="GIKPSVVVGASLGDYPALYTAGVLSASDAIFLAGERAL"
     CDS_motif       complement(2871..2918)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spoP_0004"
                     /evalue="3.40E-03"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="spoP"
                     /protein_end="930"
                     /protein_start="914"
                     /score="10.5"
                     /tool="antismash"
                     /translation="FSGQGTFYPGIGRELF"
     aSDomain        complement(3219..4505)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spoP_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.60E-141"
                     /label="spoP_PKS_KS.1"
                     /locus_tag="spoP"
                     /protein_end="814"
                     /protein_start="385"
                     /score="463.2"
                     /tool="antismash"
                     /translation="IAIVGMSCRFPGGANDTQLFWNLLEEGRDVHTKVPADRYDVETHT
                     DPTGKTRNTSLTPFGCFVDQPGLFDAGFFNMSPREAAQTDPMARLGIVTAYEALEQSGF
                     VQNRTAASKKERVGTFYGQACDDYREVNSAQEVDTYYITGGCRAFAPGRINYFFKFSGP
                     SFSCDTACSSSLATIQIACTSLLHNEADTVVAGGMNVLTNVDPYAGLSRGHFLSKTGGC
                     KTWDADADGYCRADGVGSIVMKRLADAEADNDNILGIILASATNHSADAVSITHPHAAT
                     QCELYRNVMGMAGVDPMDVGYVELHGTGTQAGDVTEITSVTGVFAPETPRRESPLHIGA
                     VKGNVGHGEAAAGVMALIKVLLMFQNSHIPRHIGIKNGLNPKFPNLNQLNVAIPFEGVS
                     WPRREDKTRYAFVNNFSAAGGNTALLLQEP"
     CDS_motif       complement(3555..3602)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spoP_0003"
                     /evalue="1.50E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="spoP"
                     /protein_end="702"
                     /protein_start="686"
                     /score="11.1"
                     /tool="antismash"
                     /translation="YVELHGTGTQAGDVTE"
     CDS_motif       complement(3795..3833)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spoP_0002"
                     /evalue="5.50E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="spoP"
                     /protein_end="622"
                     /protein_start="609"
                     /score="13.1"
                     /tool="antismash"
                     /translation="WDADADGYCRADG"
     CDS_motif       complement(3978..4022)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spoP_0001"
                     /evalue="8.10E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="spoP"
                     /protein_end="561"
                     /protein_start="546"
                     /score="15.0"
                     /tool="antismash"
                     /translation="GPSFSCDTACSSSLA"
     aSDomain        complement(join(4920..5066,5128..5428,5516..5751))
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spoP_SAT.1"
                     /evalue="2.70E-44"
                     /label="spoP_SAT.1"
                     /locus_tag="spoP"
                     /protein_end="247"
                     /protein_start="19"
                     /score="143.4"
                     /tool="antismash"
                     /translation="RLRTQSKANDGAILRIFLQKATQTLREEIRLLPVEQKAIFPPFNN
                     ILDLAEAQSLRRGYLGEAIDGVLLNVMHLSLFIRYHELHPQEFTYGRVSACVTVQGYAR
                     LAGAAVLVSPTLADLPMAGAEAVRMAIRLGTVMEETSRGLEAREPESTPESWAAAIADM
                     DADTVQEELDAFNTSTHNPIPSQIFISVVGIGSTVISGPPTKINQLFQVSGKLRYSNFT
                     ILPIYG"
     gene            complement(<6621..>7716)
                     /gene="spoB"
     mRNA            complement(join(<6621..7424,7573..>7716))
                     /gene="spoB"
                     /product="metallo-beta-lactamase"
     CDS             complement(join(6621..7424,7573..7716))
                     /codon_start=1
                     /gene="spoB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     140.6; E-value: 7.8e-43)"
                     /gene_kind="biosynthetic-additional"
                     /product="metallo-beta-lactamase"
                     /protein_id="QNT61261.1"
                     /transl_table=11
                     /translation="MAVATNNYPDITAFGDYIDAQTRLLPELPEVEVLTPRIIRVMGCN
                     PGRMQLQGTNTYLLGTGPEKILIDTGAGDRRWAELVSSLVNDWGILIRHVLLTHWHGDH
                     TGGVPDMVRLYPNLKDDIFKCDPAHGQQAIVEEQVFTVPGVTVRAIHTKGHTADHMCFL
                     MDEERALFTGDTLLGNGANTAVENMSEYMTSLRKIQERDCHIAYPGHGDKIPDLTKKLK
                     QEVDRCLQRESRVLMTLRKIQKSNAAAGDRGKGGATTTELVNEMFGSLSASVRESAIQP
                     AVKEMLMKLAAEKKVGFELKAGQKRWFAKSQVVA"
     gene            complement(<8899..>10314)
                     /gene="spoR"
     mRNA            complement(<8899..>10314)
                     /gene="spoR"
                     /product="regulatory protein"
     CDS             complement(8899..10314)
                     /codon_start=1
                     /gene="spoR"
                     /product="regulatory protein"
                     /protein_id="QNT61262.1"
                     /transl_table=11
                     /translation="MSISSTLLDLPTLTRLVISRGYLCHNRLEMSVPAPCIGITFPASI
                     TMDHSQVKSASKLRSPKSRLENVRSSCDNCTKSKVRCSKNQPRCQRCIHQGVHCKYSLS
                     RKCRRRTTSTVESISGSNQPLESSRDRPSRFENGLSTLLPSNPASICDIASFTPSVAEE
                     SSNQLYEDGVRSNDSNYGDYEMLSPFGTNVDSLMDWGESMVSLDHAMLRQDLSLGHHDM
                     PTCWPLPSHGSADSLREKLPLSRRHSSPNENCSHLAISAVQSLEAPFASCSLTSFDEAI
                     ASSPGIARGLDAVIKINRAAIDTTLTILDCSCSKQEDLIFLIATICLRALSWYQASLDS
                     GSSNGSPSITSGSLSASFTASSSVSGSTSTLDVPPSMDWVSIPAINFGFYALDEEHSSC
                     MVAQLICAELSKIKSVVDKFSSKYCERDSAISTLYSAKAGENNTPFYVELEALLRDRLD
                     RTIVSAREHIERW"
     gene            complement(<11226..>12572)
                     /gene="spoF"
     mRNA            complement(join(<11226..11543,11606..11965,12018..>12572))
                     /gene="spoF"
                     /product="fasciclin domain-containing protein"
     CDS             complement(join(11226..11543,11606..11965,12018..12572))
                     /codon_start=1
                     /gene="spoF"
                     /product="fasciclin domain-containing protein"
                     /protein_id="QNT61263.1"
                     /transl_table=11
                     /translation="MALTSKIRRTLIQAATVAAVLLTVSTAVQLYVTKWRPAADQWRLT
                     QIFKGSNEPLHLPLTHSQTAWEVMKSDKNISSFVRMIEDFPDIVLGLTSVAGKFTVLAP
                     TNAAFEREPLAHDTPDFGYMMLVGYHMGPGSFSDQALLETNTISSFLNADRFFKYKQRL
                     SIQPCVDGISVNFRAKLIGPGTIAANGHVHHIDRILPIPEAVAITLRDTPEFNSFRTAL
                     IQTNVAVVVNDTSTHDGQTVFVPTNAAFEKLGRKINRFLFSPGGNTYLEALLRYHIVTN
                     RTFYSDVHYQSNGQGEIKMATGSATSLPTLVNGHDLQISIHADDSRNLITINNAVRAST
                     QDIVAMDGVIHVIDTVLLPPTASEDGSKPQEEDTSWITSLVQLFRWKTTPEELTVESLM
                     EILNPLLEPSS"
     gene            <12951..>15287
                     /gene="spoL"
     mRNA            join(<12951..13145,13251..13306,13364..13534,13590..13760,
                     13854..13979,14045..>15287)
                     /gene="spoL"
                     /product="laccase"
     CDS             join(12951..13145,13251..13306,13364..13534,13590..13760,
                     13854..13979,14045..15287)
                     /codon_start=1
                     /gene="spoL"
                     /product="laccase"
                     /protein_id="QNT61264.1"
                     /transl_table=11
                     /translation="MIALFLRVLFVLGFICPTAFSKLVREEIVLTWEVAAPNGQSREVI
                     KVNGQLPGPTFRWDEDDDVEVIVHNQMPFNTTIHWHGLLMQATPWSDGAPGITQLPIEI
                     GQSFVYKFKAYPSGTHWYHSHSRMTLMDGLHGAIFIRPKPSAPSPWSLISTDPSDIEGI
                     KKAAFNPHVAVLTDWTRLKSWEYMAVQEETKLSIFCVDSILINGKGSVFCPGEDFLVNV
                     TSLYMKYALYPSHVNDKGCFPFLRSTEGLYLETGIPEKIPLHMQHGCVPSEGGRTIFDM
                     EKGATWVSFSFVGAIEIKSIIVSIDEHPMWVYEADGQFIEPQLVDTFTIWPGERYAVMV
                     KLDKPARDYTIRVADYSLTQIISAFATLRYHGGRDLGETRATINYGGQNLTHAVQFDRD
                     HTPSFPPNKPAAPTELDAQHILYTHRWYSPWQYTLTGGGMYPEDLNAYLPLLYNPHSTS
                     WMNESLLIRTKTNSWVDLVIQVGSWPGQPIEFPHMLHKHANKMWQIGTGLGLWNYSSVY
                     EAVQAEPQSFNLENPNYRDTYVTSFAGTSWMVLRYQATNPGPWLFHCHLGTHLAGGMAM
                     AILDGVDDWPDVPQEYSPSQRGFSLGPQPSVGVEGDSYHSSEELGGPISHPLGFISPGY
                     WDSIVSRAISFLESLRSK"
     gene            complement(<16346..>17726)
                     /gene="spoM"
     mRNA            complement(join(<16346..17380,17442..>17726))
                     /gene="spoM"
                     /product="O-methyltransferase"
     CDS             complement(join(16346..17380,17442..17726))
                     /codon_start=1
                     /gene="spoM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 271.1; E-value:
                     2.3e-82)"
                     /gene_kind="biosynthetic-additional"
                     /product="O-methyltransferase"
                     /protein_id="QNT61265.1"
                     /transl_table=11
                     /translation="MTVTNSQKAADAINSKTELETLAAAISENTAILSDFLRAENLPQP
                     SFKRDAPTTVLSPSAPDHIKKAQRALIEASLKAYELATGPSEYLPNLALGYNYTAALRW
                     LRHFNIFYLVPLEGSISYSDLAKTAKVSARQLRTMARMAMTSNLFAEPKKGFIAHSATS
                     ALFVTNPSYHDWAGHLCEVSIPAASKLVEATEKWPGTTDRTETSYNLAFDTRLPFFEHM
                     ATQPHRTKQFASYMKHVTNSSGMAIEHLVNGFDWASLGKATVVDVGGSSGNACISLAKQ
                     FPDLNFVVQDLAENTSDGEATIGDYGPEIASRIKFQSHDFFQEQPVKGADVYLLRMILH
                     DWPDKEAIQISKSLARAMSSSSRILIMDSVMPIPGSIPSSLERNIRAKDIAMWMAFNSM
                     ERDLGDWEELLENIDDRLQIANVVQPVSSFMSVLEVVCKS"
ORIGIN
        1 gtctttctga gatcacctac atctattcta ttccatctat tcgcacgcag cgcccttggc
       61 aatcaattat gatgtctcaa aaggggccaa accccgcagc cgtacggctt tgatcaagtg
      121 acaagtaaga atggagctca gtgatattat tatgatatga attagtaagg atgaagataa
      181 tttttctgct cacaactctt gataaagata actcataccg aacaaatagg actgggatac
      241 acacgttgta attaacaaca acaaaactac agacccccgc caatcacaat gacaaacatc
      301 aaagagagac ggagacaaaa gaaaaccaat gaggccttcg cggctttaca cagtcgctct
      361 atgactggcc tttagctgta gtcaaccagc catgcttgaa ggtcgttcag cgtgggacac
      421 tccaagaaca gtgaagatgg cacttgaact cccagctctt ctttgaactt ctctgccagc
      481 acaagtgata gcagagagtc tacgccgatc gaggcaaatg atgtctcgcc tgtcaattct
      541 gagatatcta ccgcagtttc tgcggcgagc aagaccaatg catcttttac aacttggttc
      601 tcactgccaa tggaatcaac aactattggg gtcatcttgg gagacgatgg ctcagttggc
      661 ggcgtcagtt ctcccatgac aggttcatct tctaggggag gagttccgct ggtgaaactg
      721 agagggggcg tcaaagcttt cccgggtgcc agttgcttct ttggaaggac cggagccggc
      781 atatgctttg gcggagccga cttgggatgc gaatcgggcg gactaaagaa cttgctgagc
      841 aagactcgtg ggaactggcg gaacgtcata ccaccgcaca gtccgataac ttcagaacct
      901 tccaagagat agacatcgcc ggagaagtaa cctgcttcgc tggaaggcgt catacggacg
      961 tatgttctgt accggccccc gggaaccaaa ggcttcgcga aacggagaga cttccagcca
     1021 ggtgtaacaa agaagttatt tttgttatcg actgatgtcc caccgttgac aataaagcca
     1081 gcaagatgga tgatgctgtc gatgtggtgt ggtggtactg tccaagtacc cccaacttct
     1141 tgtgctagga caacacttcc cgtggcttcc atgccatgca gaactacaga atgcatgcca
     1201 cggtacttct ccgaataatc caccaagtta ttgaacagta agtataccaa gtctcgtgtc
     1261 agcctgttgg caacgccgtc atctgcgaga cggtccagca tatcgattct gctggcaaca
     1321 agatgagcgt ttggtgccca ttcgttcagc caggtttcag tgtcgccgta ctccactgtt
     1381 gctgtggcaa atgtgtggtc agctacttgg ccatattcat ccaccatata ccacctcagc
     1441 tgcgtacaac tcttggacaa atctgctgta gcactgatct ggatatattg tggccgagac
     1501 ttgtccttgc gtgcaacaac tgcctcgact acctccaatt ttgtcacatt tactccaggt
     1561 atcttggaac ccggcttgat gcgtgagtag atgtattttc ctaatgtgaa ggcgacatca
     1621 gcgtgaatgg atgaagtgat cacggcacat ttgttcatgc ggtgaccgtc gactgcttca
     1681 taaaactctg gtctcataag atcacagcga acaacaactt ttccagaatt ttctagaatg
     1741 acttcatcca taacgtcgtg gatcaaagac gtacgtagag tagatggaac cgtctgtgca
     1801 tgctccactg cagaagctgt tcttgacaca tgagcctgat cttttgtcaa catccagtca
     1861 ccgttgtatt gcatccagta attcttttca ttccacccat aggctggcaa attaatgagt
     1921 cgtagatctt tttcgaatcc cctatgccat tcattccaat cgacttcaac accagagttg
     1981 tacaggcgag ccaaggtatc agtcatcgta gcccagttat cttgatctct tctgaaagtg
     2041 ccttcagcaa aagcaacatc cggagtgagg ctcttgacga agggtacgca gattggatgc
     2101 gggccgatat caatccagac ggtgttctta tcaaccaagc ccatttcctg cccttgctca
     2161 agagcgccga ccaagttcat tgtctcacga gttgccctcg ccatgtagtt tgcattgatg
     2221 gtttcactat cgaatacagc ctcactgagc agagacgaca ggaatgggat gcttggcgcc
     2281 ttgaatgtaa caccagtcgc aatcctttca aatttctcaa tgactgggtc catttgaacg
     2341 gagtggaagg caaacggcac gttcagctga tggcatttga agccctggga ttcaagatgc
     2401 gcacgaaggt ctttgatctc ttcaactgtg gcgctgatgc agatgtcact tcgtccgttt
     2461 atacaagcta cttcaaagtg acaaccatta gcggcctcac ggatttgttg ttcagtagcc
     2521 cgaacagcca acatagtgct ggtaaaaggg gtacattccg cttcaagaat cagggcccgc
     2581 tctccagcca agaaaatggc atcgctcgca gacaggacac ctgccgtata caacgcaggg
     2641 tagtcgccta agctagctcc gacaaccacg ctgggtttga taccgagagc agagagagtg
     2701 ttagataagg caatgccaac acatacgatt gtcaattgcg tgatcatagg tccgaagaca
     2761 tagccgtcct caacttcacc cgtgatagca ggcaagaacg agggatagcc atgggtaaag
     2821 caagtcgcct ccagctgcaa gatttgtgtg cggaagaatg ggtgcgtctt gaaaagctca
     2881 cggccaatac ctgggtaaaa tgttccctgg cctgagaacg cgaacgctac agatggcgat
     2941 gagttgggaa ctggcggacg gctgtcaaca gttggtaact cctttcgaag gccatcgaga
     3001 attccaccca ggctagtccc ggtaacggag atgcggtgac tatgatgcag tcgacgagct
     3061 gttgtcgtat atgatagatc ggatagcgaa atgtcggagt tcttttccaa atgtgcgatc
     3121 atattctcca agttcttctt gagcgacact ttgcccttcc cagacacggc cacggcccaa
     3181 gcacttctgg ggtcttcagt acgatcccgg ggaactggtg gctcctggag caacaaagca
     3241 gtattgccac cagcagcgct gaagttattg acaaacgcat agcgcgtttt atcttctctg
     3301 cgtggccaag ataccccttc gaatgggatc gcaacgttta gctggttgag attcgggaat
     3361 tttgggttga ggccattctt gattccaata tgtcgcggaa tatgagaatt ctggaacatt
     3421 agcaatacct taatcaatgc catcacaccg gctgcagcct cgccgtggcc cacgtttccc
     3481 ttgacggctc caatatgcaa cggtgattcg cgccttgggg tctcaggtgc gaagactccc
     3541 gtgacagaag taatctccgt cacgtctccg gcttgggtac ctgttccgtg gagttcaaca
     3601 tagccgacat ccattgggtc aacgcctgcc atccccataa cattccggta aagttcacac
     3661 tgggttgcag catgtggatg tgttatagaa actgcatctg cagaatgatt tgtggcagac
     3721 gcaagaatta taccgaggat attatcattg tcggcctcag catccgctag gcgcttcatg
     3781 acaattgatc caacaccatc agcacggcaa tatccatctg catctgcatc ccaggtcttg
     3841 cagcctcccg tctttgataa gaaatgacca cggctaagac cagcataagg atcaacgttt
     3901 gtcaggacat tcataccgcc cgcgactaca gtatcagcct cattatgcag cagagaagtg
     3961 caagcaatct ggattgtagc caaactggac gaacatgctg tgtcacagct gaaactgggg
     4021 ccagagaatt tgaaaaagta gttaatacga ccgggagcaa atgctcgaca tcctcctgtg
     4081 atgtaatagg tgtcgacttc ttgcgcggag ttaacttcac gatagtcatc acaagcttgc
     4141 ccatagaatg taccgacccg ttccttcttg ctggcagctg tgcggttctg aacgaatccc
     4201 gactgttcca acgcctcata tgctgtgact ataccgagac gggccattgg gtcggtttgt
     4261 gcagcttctc gtggtgacat gttgaaaaat ccagcatcaa aaaggccggg ttgatcaacg
     4321 aagcacccaa agggcgtcaa gctggtgttt cgtgtctttc cagttggatc agtatgagtt
     4381 tcgacatcat aacggtctgc gggaaccttg gtatgaacat cacgaccttc ttcaagaagg
     4441 ttccagaaaa gctgtgtgtc gtttgctcca ccagggaatc ggcatgacat gccaacgatt
     4501 gcaattctgt catccgcgat tctatttgtt tcctcatttg gagcagcaac ggcacagtca
     4561 acaagatcga tagtcttgat tttcgatgcc ggcagccgag agcgcacttc ggtcatgagt
     4621 tgctctatta agggcgaggt attaaagtag tggacgttga agacggcatc ctctgctgat
     4681 gataaggcac cgacgacacc gtcaaacact ttctgccagc gaattgtatc cagcaggact
     4741 tcagacacca cttttgtgaa cgcgtcaaga gccctgtcac cagaaattcg tcttccatca
     4801 gcgctagaaa aaatagaaat ggtatcaacc agaggacggt tagccacttt agtagtaaca
     4861 gtttctataa cttttgcaac atggctcttg ttataaaggt gaggtgcatg acccaggccg
     4921 ccatagatgg gaaggatagt gaagttggag taccgtagct tcccagatac ctggaaaagc
     4981 tgattgatct tggttggagg tccactgatt acagtgctac caattccaac tacactgata
     5041 aatatctggc tggggatcgg attatgctgt cattgtctag gtttagcttt ttcacatact
     5101 ttgcaagttg attgagcgtg ggcttaccgt tgacgtgttg aacgcatcga gctcctcctg
     5161 aactgtatcc gcatccatat ccgcaatggc tgccgcccaa ctctccggtg tagactctgg
     5221 ctctctagcc tcaaggccac gagatgtttc ctccatcacg gtgcccaacc ggatcgccat
     5281 acgcactgct tcggcacccg ccattggaag gtcagccaaa gttggcgata ctaggactgc
     5341 agcaccagcc aaccgagcgt atccctggac agtaacacat gccgacactc tcccgtaggt
     5401 aaattcttgt gggtgtagtt cgtgatatct gaatttaaat attaggcccc gcgaaataga
     5461 acaataaagg cacgcagggc tactcgttcc gtttgagaaa gaccttgaaa cttaccttat
     5521 gaataaactt aggtgcatga cattgagcaa aacaccatct atagcttctc ccagatatcc
     5581 acgcctcaag ctctgggcct cggcaagatc gagaatatta ttgaatggcg ggaagatagc
     5641 cttttgttcg actggcagta atcgaatctc ttcccgcagt gtctgtgttg ccttctgcag
     5701 gaatattcga agaatcgctc catcattggc cttgctttga gttcgaagcc gcctgaagat
     5761 ggccaaatga tcagatggca gctggtttgt aaaatgaacg agcttcatct ttgcgatgag
     5821 ggtatattgg aacgacgagt taacgagagt acgtgtcagc gagcaagaat gaaggtatgt
     5881 agtatatgag aaatatcttc agcgattatt catgcacgtt ccataggtgc aggacaaaaa
     5941 tctatttcaa atagcccgtc ttacagattg tctataggcc ggtatgctgt ggaggctcct
     6001 ttttagatct tttccaacgt tgtacataat ctcttctaac taattccaga tcgcaaatgc
     6061 ctatttccag cgatttagaa acaagtgtgc cgaaacatgt tttatctctc ccgagtatgc
     6121 acgcgagaac gttcggtaga agtcatcgtc ggacagtcac ttatggccaa tacttccaga
     6181 cactagcatt atgattagga aatcccctgt gagattgacg cgatatcctt tgtttggata
     6241 cacagtaact gcgtgttgtg gttctgctcc ggaccatctc ttccattctg agagtatact
     6301 caaccgatct tctgtcccac atcggaatcc caccttgtct tgtgggtgtc tcctatgagt
     6361 acggtgtaga tgcatgcatc gggtatacat gtatctcata tgcacgaata ttggtttaga
     6421 gttgatcaga catgcatcgg ggcagcatca taatccatct cacagatatc ttcacacatt
     6481 gcgaatgcaa ggtgacgacg tgataaacca ataatagaat gagatgaaaa tacgttcaca
     6541 ttctgtacga tacagggcgg caactctgca tatgctgtat ctgataaact gacggctttc
     6601 ctattacggt ctctgagata ctacgctaca acctgcgatt ttgcaaacca tctcttctgc
     6661 ccagctttta attcaaagcc tacttttttc tcagccgcaa gcttcatcaa catctccttc
     6721 acggctggtt ggatggccga ttctcggacc gaagcagata gacttccaaa catctcattg
     6781 acaagctcgg ttgtggtggc gcctcccttc ccgcgatctc ctgcggccgc attcgacttc
     6841 tggatttttc gtaacgtcat cagaacgcgg ctttcacgct gtaggcagcg atccacttct
     6901 tgctttaact tcttcgtgag atctgggatt ttgtccccat gccctggata tgcgatgtga
     6961 cagtcccgtt cctggatctt tcgaagactt gtcatgtact cggacatatt ctccacggcc
     7021 gtatttgctc cgttacccaa taacgtatct cccgtaaata gagcacgctc ttcatccatt
     7081 aggaagcaca tgtgatctgc agtgtgacct ttcgtatgga tagcacgaac agtcacacca
     7141 ggaaccgtga acacctgttc ctccacaata gcctgttggc cgtgagctgg atcgcattta
     7201 aaaatgtcat ccttcaaatt gggataaagt cgtaccatgt ctgggacacc cccggtatgg
     7261 tctccatgcc agtgtgtcaa cagaacatga cgaatcagga ttccccaatc gttgacgaga
     7321 gaagatacga gctctgccca gcgcctatct cccgcacctg tatcgatgag gatcttctcg
     7381 gggccagtac cgagcaggta cgtgtttgtg ccctgtagtt gcatctagcc aggaaaatca
     7441 gccgccttca tctcatatca tgtctaaaag aacggatgtc gtgaaaacaa aaacagtgac
     7501 acggccggct atgatgcaat gtgataggcc cctcgaatgc ccaagaaaaa ataggaaaga
     7561 taacaatctc acccgaccag ggttacaccc cataacacgg atgatacgtg gtgtcaatac
     7621 ttccacttcg ggtagctccg gcagcagacg tgtctgggca tcgatgtaat ctccaaacgc
     7681 ggtgatatcc gggtagttgt tggtggcaac ggccattatc gtctaattgc tgtacggctc
     7741 gtattctgag agcttagctg gtagctgggt gggcggggcg gaaggtcgag gagaatagtg
     7801 tgtggatctg agaacgcctc gatgggacaa ctgaccaatg agaaacgaag gcaaaaatga
     7861 caggattcca agaatagggc aagccggaca agttcaggga gataatcggc tcagcaggcg
     7921 gaggagttga aagccgttag atatcaacgc attatagtta tttctcatca tatagggctg
     7981 caaagccact ttgcatttag cgtcggaaac gcatggacgt tcccgctgcg atctgcagaa
     8041 caccgtgcag tgactcgaac tgtatgattg gggtatgcga gtctatgaaa ccagccacga
     8101 acgaacctgt cttagccact cacgagaggg aagtgccgcg ggttaagcat actgtacatg
     8161 gtttgtactg gtaaacgttt aactttcaac ccctgtcgag ctcaatgcag agtcgagaca
     8221 ggtagtctca gaacaggcag attagattcc ccatcgatac atctatacag agtggtgtgg
     8281 tgatcatagc ctatcacagg atatcatagc ccatcgtagc ccatcgcagc ccatcatagc
     8341 ccatcgcagc ccatcatagc ccatcgttgc ccgctctgtg ccgcccggcc gttgttgact
     8401 tggagtacga ccgcacaccg gctcggcgtg ggacgtgccg tattgcatgt actacgggta
     8461 catatcaacg tcacatcggc acgagaatga ttctcctgga cgtgccttgt gtcacaagga
     8521 tgcacaggac gcatttatca taagcagggt gcacattgca ccatcatagc gtatatcccc
     8581 cagagtggat caaggtagca tttccccgag tggatttgga tcgctgggga gaaagtcagg
     8641 agttaatcgt tccgcagtcg ttgttatacc cacctttcgg gccgtagggg tggtctgaca
     8701 attgtgaggc gttgcttgtg atatctcttc attaggtacc taactacgta gctactattt
     8761 cccactgaaa gtagggccac cacaatgcag ccacccatga acccattagt cattttttca
     8821 tggtctattc gtgcttgctg ccatcccatt cgttttatct agttccattc aatataatcc
     8881 tacactgtaa tatagtaatt accatctctc tatgtgctct ctcgcagaaa caattgttcg
     8941 gtccaggcgg tcgcgtaata aggcctccag ttctacgtag aatggagtgt tgttttcgcc
     9001 agccttggcg gagtacaacg tcgagattgc gctatctcgc tcgcaatact tgctggaaaa
     9061 tttgtcaact acacttttga tcttactcag ctcagcacaa atgagctgag caaccatgca
     9121 gctggagtgc tcttcgtcga gtgcgtagaa tccaaagttg atagcaggaa tagacaccca
     9181 gtccatggat ggcgggacat ctaaagtaga cgtagagccg ctgacggacg acgaagcggt
     9241 gaatgatgcg ctcaaagagc cgctggtgat gctggggcta ccgttgctag agccgctatc
     9301 taggcttgct tggtaccatg aaagggctcg caaacagata gttgcaatca agaatatcag
     9361 gtcttcctgc ttcgagcaag aacagtccaa tatagtgagg gtagtatcaa ttgctgctcg
     9421 attaatcttg atgacggcgt caagtccacg tgctattcct ggtgaagatg cgattgcttc
     9481 atcgaagcta gtcagagaac aggacgcaaa gggcgcttcg aggctctgga ctgcggagat
     9541 ggcaaggtga gagcagttct catttggaga gctgtgcctt ctgctcagtg gcagcttttc
     9601 tcgcaaagag tcagccgacc cgtggcttgg aagtggccag catgttggca tgtcgtgatg
     9661 gccgagtgat aagtcctggc gcaacattgc gtgatctagc gataccatag actctcccca
     9721 atccatcagg ctgtcgacat tggtcccgaa tggacttagc atttcatagt ctccgtagtt
     9781 ggagtcgtta ctcctaacgc catcctcgta cagctgattt gatgactcct ctgcgacaga
     9841 tggggtaaag cttgcaatat cgcaaatgga agcagggttt gacggcagta gcgttgacag
     9901 tccattctca aaacgtgatg gccggtctct cgaactttcc agtggctggt tggatcccga
     9961 aatagactcg acggttgacg tggttcttct tctgcacttc cgagaaagac tgtatttgca
    10021 gtggacgcct tggtgtatgc agcgctggca tcgcggttga ttcttgctgc agcgcacctt
    10081 tgacttcgta caattatcac agctgctacg gacgttctca agtcggctct ttggagagcg
    10141 gagttttgac gcgctcttta cctgggaatg gtccatagtg atcgatgctg gaaaagtaat
    10201 tccaatacag ggcgcgggta ctgacatttc aaggcgatta tgacacaaat atcctcggct
    10261 gatgacgagc cgtgtcagcg ttggtaaatc gagaagtgtc gaggaaatcg acatcggtgt
    10321 ccaatggctg gcgatctggc gatccgcagc cgttcatgca ggtgatccgc acgcggagct
    10381 actcaaatgg aagctgtatt ggttgcacaa cagaggcaca gtagcacacc tctcttttat
    10441 tgttccattc cgtgcatccc tgtacgattg cttcacgacc tggaccgcat tgtcgtgctt
    10501 atcatctatc gcaagatccg cacgacgggg gcccgaaatg gtcggtgaat cacggtaaca
    10561 tcggagtggc ctctgtatgt agtggatgta gtgtctcgtt gggacactcc tgcatgcacc
    10621 aagaggtcaa tgcaccagat cctgccttaa ataagcctcc catctcgatc aatctgacga
    10681 accttgcgct agtcctcctt gggtatgcga ttccgccgtt ctgcgctagc tgggtttccc
    10741 caacaagagc tacctcacta tctcactagc acatagctaa ttagatggag cgatggcgcg
    10801 gagtgggtcc ggcgggggag gtgccggggt ccggtggccg gggtccggca gccggggcaa
    10861 ccgcgggcaa gggggcgaga acaacacttc gacagcacat gctgcagatc ttcaacgtaa
    10921 ctgccccggt ccccgccttc cacccttgtt cggcagcaac ctttggataa tcgatagtcg
    10981 cccaagtgat gatcgtcaaa attacgccct gaatatcgat ctcaccggtc gccggtgttg
    11041 actgctctac agacttgggc ttggacttgg actttggttt ggacttggac ttggacttaa
    11101 acttggctgg gcacgtgaat ctgaaatcgg catctccagt cccctgaata gtcatccctc
    11161 tatggcttca tgtgttccac ggcatgcaga cttccgacga tttgtgtgat gagatttccg
    11221 tattttcatg aactgggctc aaggagcgga ttcagtatct ccattaaact ctccacagtc
    11281 aattcctcgg gtgtagtctt ccagcggaac agttgcacca gagatgtaat ccatgaggtg
    11341 tcctcttctt gtggtttgct gccatcctca gaggctgtcg gagggagaag cactgtgtcg
    11401 atgacatgga tgaccccgtc catggcgaca atgtcttgtg ttgaggctcg gacagcatta
    11461 ttgatcgtga tcaaattgcg agaatcgtcc gcatggatag aaatctgaag gtcatgtcca
    11521 tttaccagag ttgggaggga agtctgccaa ttcattagag atgcgcatga tagggttgaa
    11581 ggggcagata tgaggtgaaa cttactgcag atccggtcgc cattttaatc tcgccttgtc
    11641 cattggactg ataatgaaca tctgagtaga aagtgcgatt tgtcacaatg tgatacctta
    11701 ataatgcctc aagatatgta ttgcctccgg gactaaacag gaaccgattg atctttcggc
    11761 ccaatttttc aaacgcggca ttggttggaa caaaaacagt ctgtccatcg tgagtggatg
    11821 tatcgttgac gacaactgcg acgtttgttt gaatcaaggc ggtacggaat gagttgaact
    11881 ctggagtatc ccgtaatgtt atggcgactg cctcgggaat tgggagtatg cgatcaatgt
    11941 ggtgaacgtg gccgtttgca gctatcttga aaaatgtcag ccgtcttgac gcgtttaata
    12001 agtataatta tactgacagt tcctgggcca atgagttttg cgcgaaaatt cactgaaatt
    12061 ccatcaacgc aaggctgaat actgaggcgt tgcttatatt tgaaaaatcg gtcagcattc
    12121 aaaaaagatg atatcgtgtt tgtctctaag agggcttgat cagagaaaga accaggcccc
    12181 atgtgatatc cgaccaacat catgtagcca aagtctggag tatcgtgtgc caggggctcc
    12241 ctttcaaatg ctgcgttggt gggggccagg acagtaaact tccctgcaac tgaggtcaag
    12301 cccagtacaa tgtctggaaa atcttcgatc attctcacga aagatgagat gtttttatct
    12361 gatttcatta cctcccaagc tgtttgagag tgagtcaatg gaaggtgcaa aggttcgtta
    12421 ctccctttaa atatctgagt gagcctccat tgatccgcgg ccgggcgcca ttttgtaacg
    12481 tagagctgga ctgcggtaga gacagttagc agtactgcgg ctactgttgc agcttgtatg
    12541 agggttctcc ttattttcga agtcaacgcc atggtcggcg atatgaagaa agatttgtct
    12601 gtcataagag gccaagtcac agaagatggg ttgtaaaaag ggaggaagct tgtgaagaaa
    12661 attgcaacgg ataaccgcat cgatgaagtg tgattgccac ttaacttggc tcgggagccg
    12721 gtggcaagcc ccgataacag accgtgatag ctgccgagga gctcgggcct caacccttat
    12781 aatgtttcaa gagaaccaag acaaccagac gcgacaacct gcaaggccac ctgaccgtgc
    12841 gattacatct atcaatccat cgtcgcgtaa tcgcgtgagg ttcttcataa acaggaaaac
    12901 tcaccaccct atgttttcat acatagagag aagagagact cctgcccgtc atgatcgcat
    12961 tgtttcttcg tgtactattt gtcttgggtt tcatatgccc gacagctttc agtaaactcg
    13021 tcagagaaga aatagtgttg acatgggagg ttgctgcccc caatggacag tcccgggagg
    13081 ttatcaaggt caatgggcaa cttccgggac ctacattccg gtgggatgag gacgatgatg
    13141 ttgaggtaag ttaaaatctc ataattaatg tccattatgg agatatccac tattgttcct
    13201 tgcgacgtat ttctaagata cggtaactga tgagatactc aataccacag gtcatcgttc
    13261 ataaccaaat gccattcaac accactattc actggcatgg cctactgtga gcaatttttc
    13321 ccgctataca gacttataac actatctcat atcttgaaaa cagaatgcaa gctacaccgt
    13381 ggtcggatgg tgcaccagga attactcagc ttcctatcga aatagggcag agttttgtgt
    13441 acaagttcaa agcgtacccg tctggaacac actggtatca ttcgcactcg aggatgacct
    13501 tgatggatgg tttacatggt gcaatattta ttaggtacta atttatcgtt gtccctcata
    13561 ttaagccagt catactaact cttttcaagg cccaaaccta gcgcgccttc accttggtct
    13621 ttgatttcta ctgaccctag cgatattgaa ggcataaaaa aagctgcatt taacccacat
    13681 gtggcagtct taaccgactg gacccgtctt aagtcttggg aatatatggc ggtacaagaa
    13741 gaaacaaaac tttcaatctt gtatgtcatg ctcccaccat ctttcacaaa gtcgtagttt
    13801 gacggaacga cggaatgacg gaattattaa caaatgctct ctctccaatc tagttgcgtg
    13861 gatagtattc tcatcaatgg taaaggcagt gtattctgcc caggggaaga ctttctcgta
    13921 aacgttacct ctctttacat gaaatatgcc ttgtatcctt ctcatgtcaa tgacaagggg
    13981 taagagtcac acaattctta tatccagcag atcacacatt tctaacttat tttataactc
    14041 acaggtgttt tccattctta aggtcaactg agggattgta tctagagact ggaattcctg
    14101 aaaaaatacc actccatatg caacatgggt gtgttccatc agaaggaggc agaacgattt
    14161 tcgacatgga aaagggcgcc acttgggtga gtttcagctt cgtcggggcg attgaaatca
    14221 aatccatcat agtctctatc gacgaacatc ctatgtgggt ttatgaggca gatggacagt
    14281 ttatcgagcc gcagctggta gacacattta cgatttggcc gggcgaacgc tacgcagtga
    14341 tggtgaagtt ggacaaaccc gctcgggatt acactatccg tgtagctgac tacagtctga
    14401 ctcaaataat atccgccttt gctacattac gataccacgg cggccgtgat ctcggagaga
    14461 cgcgtgccac catcaattat ggtggccaga atctcactca tgctgtccag tttgatcgcg
    14521 atcacacacc ttcctttcct ccaaataagc cggcagctcc tacagaacta gacgcccaac
    14581 atatactcta cacacatcga tggtacagcc catggcaata cacattaact ggtggtggaa
    14641 tgtatcccga agatttaaac gcatacctgc cactgcttta caacccacat tctaccagct
    14701 ggatgaatga gagtctccta atccgcacca agactaattc ttgggtagat ctagtcattc
    14761 aggtcgggtc ctggccgggt caacccatag agtttccgca catgctacac aaacatgcca
    14821 acaagatgtg gcaaataggg acgggtctag ggctgtggaa ctactcttcg gtgtatgaag
    14881 ccgtccaggc agaaccccag agtttcaatc tcgaaaatcc aaattatcgg gacacatatg
    14941 tcacatcgtt tgccggaacc tcctggatgg tgctcagata tcaggctacc aatccgggcc
    15001 cctggctttt tcattgccat cttggaaccc acttggcggg tggaatggct atggctattc
    15061 tcgatggtgt ggatgactgg ccagacgtgc cgcaggaata cagccccagc caacgtggtt
    15121 tttctcttgg accgcagcct tccgttggag tagaaggcga cagttaccac agctcggaag
    15181 aacttggcgg gcccatcagc cacccactcg ggtttatcag ccctggttat tgggattcaa
    15241 tagtgagccg agcaattagc tttttggagt cgcttaggtc aaaatagacg tggccagaga
    15301 gctgcgtagt aatggtaatg tgtttatgag ttggtttttc actattgcta gatcctggat
    15361 ccaagaggaa atgtgctgtc tatatgtcta tatattctca ccagaaatag atatctgcat
    15421 ttcgcttcat attattgaaa aacgcgtcga tcgcccatgg actaaagact ggtcaacttc
    15481 ataacatgaa tttcttcgcg gtatcatttt ctcatcgatc catgtagact accctcgtcg
    15541 tgaattatcg tggatagaat acgtcgttcg tggtcgagtg gctgtccgct caccaccgta
    15601 cgcaaatggg aacgccaaaa cccgagcccc ccgcccgagg tctcagattc gggcgagcgt
    15661 cagacagaga ccctagcacc caccagtgac ccgattaata aagcccgaaa tccaccccga
    15721 cctgcataat gcgtggcgta tttttgggcc ggtcccgact tttgggggtg gggctcccct
    15781 gagacgggct tgttcacacg catgtctcgg gtgtcgctac taccgtacca cttacaatac
    15841 ggatccattg aaacctgtac gggtctgttg tcgaattaaa caaatatttg gcgattgacc
    15901 gcaaacagag cacatctccg tacagacttc aataaggccg tattgtgcag tacttctacc
    15961 catccggagc cctgcctcaa tacagcatat ttcgtcgagt tcgtgtctca atacatattg
    16021 acggagttgg acgtgttaaa catccgagag agacagctca tttatcatat tggtggcgac
    16081 cgccgcctac cagccaagac agccactcct gcagctttgg acagtgctct gcattggggc
    16141 gtttgttgga agattccggg cttctcaaaa atatagggca aagaaacaaa cagcggccaa
    16201 aatatcttcg aattacaaag cttaacatta cagtaataca aaaattgaag tgctattatt
    16261 tgttctatat cttggacagt tccgatggct acaaccagtt aagcgcatgg tgtccaagga
    16321 aagcctcaga gtgcccaagg caaatctagg acttgcatac aacctctaac accgacataa
    16381 agctgctgac aggctggacc acatttgcaa tctgcaaacg atcatcgata ttttccaaaa
    16441 gttcctccca gtctcccaag tccctctcca tgctattgaa tgccatccac atggctatgt
    16501 ctttcgctcg gatattccgc tcgagcgagg atggtattga cccaggaatg ggcatgacgg
    16561 agtccataat aagaatccga gatgaagatg acattgcacg tgcgaggctc ttcgaaatct
    16621 ggatggcctc cttgtcaggc caatcatgca gaatcatgcg tagtagatag acgtcggcgc
    16681 ccttaaccgg ttgctcttgg aaaaagtcat gactttgaaa tttgatgcgc gacgcaattt
    16741 cggggccgta gtctccaatc gttgcctctc catctgaggt gttctctgcc agatcttgga
    16801 cgacaaagtt aaggtcaggg aattgcttgg ccagtgaaat gcatgcattt cctgatgagc
    16861 ctccgacatc cacaacggtt gccttgccga ggctagccca gtcaaacccg tttacgaggt
    16921 gttcgatagc catgccggag ctattggtta cgtgtttcat gtagctcgcg aattgtttcg
    16981 tcctatgagg ctgcgttgcc atgtgctcga agaatggcaa acgagtatca aatgcgaggt
    17041 tgtacgacgt ctctgtccta tccgtagtac caggccattt ttccgtcgcc tcaaccagtt
    17101 tagaggcagc aggaattgag acctcgcaca aatggccagc ccagtcgtgg taacttggat
    17161 tggtgacaaa cagcgcagag gtggcactat gtgcaatgaa ccctttcttg ggctcggcga
    17221 aaaggttgct ggtcatagcc atacgagcca ttgtccgcag ctgtcgcgcg gacacctttg
    17281 ctgtcttggc caggtcagag tatgaaatcg agccctcgag aggaaccagg tagaagatat
    17341 tgaagtgtct taaccatcgt aaagcagcgg tgtagttgta cttctcacat gtcagctttc
    17401 atgactcaac aaagaagtag acgacggaga gcattgcata cacccaaagc taaattagga
    17461 agatattcgc taggtccagt agctaattca tatgctttca aggatgcctc aatcagggcc
    17521 cgttgggctt tcttgatgtg gtctggtgca gagggcgaga gcactgtcgt aggcgcatcc
    17581 cgcttaaatg atggctgtgg gagattttca gcacgaagga agtcgctaag aatggcagta
    17641 ttctcagaaa tagcggcagc gagtgtttcg agctcagtct ttgagtttat agcatctgct
    17701 gctttttggg agtttgtaac tgtcattttg gagtctgcga acttgacgct tccgggcggt
    17761 gacccggact gcaaatgcag gtatttcatg agcttggaga ccacgctcat attgtcaaaa
    17821 taacgaaagt ctttaagtag tattacagaa tgaaaatcga acaaggcgta aaattgatag
    17881 cagacctcaa ggtactacgg ccctatatag ccaaagcttt gtgtctcaga gtccggacag
    17941 acatcgggtc cgaaatgttc cccggagttg aagatgcccg atatcaaatc cggcggagac
    18001 aggctgacat atttcaaagt tctataatta aattctgcga gtggcatttg tttgagtgtg
    18061 tttatgctct gtaaatgaag gttgagcccc gaaacgttta tcttccatag cttttggtct
    18121 ctggcgttaa aatcgaatgc ataaagcatc ttgcatattg attgacaagg atgcaaccag
    18181 cataactgta tattcgactt gtcacacctc cgaagagatg gtgaaaaaat ttcgtagctg
    18241 ccggaccagt gacgaggagg atattttggc ttgctcaaga gtgtgcggtc acgcttctgc
    18301 gccttgataa tcagctcaag ctgtgaaata
//
