LOCUS       BGC0002508             11423 bp    DNA     linear   BCT 08-SEP-2020
DEFINITION  Streptomyces pathocidini strain CGMCC4.1633 8-azg biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0002508
VERSION     BGC0002508
KEYWORDS    .
SOURCE      Streptomyces pathocidini
  ORGANISM  Streptomyces pathocidini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:52:36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11423
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1173)
                     /codon_start=1
                     /product="8-AzgA"
                     /protein_id="QLM04708.1"
                     /transl_table=11
                     /translation="MSPEEERCHSDTASAGPEAVRALAEEFVTLYHRERPEAGSADRRL
                     AEVAAEISRTGTYTHTAQELDFGAKVAWRNSIRCIGRLYWQSLIVRDRRKVDSADQISR
                     EIVRHLCQATNGGRIRPCVTVFAPELPRRPAPRIWNDQLVRYAGYTRSDGSILGDPVSV
                     DITAAAQNLGWPGGPGTPFDVLPLIVHGRDDKPRWFDLPDSAVLQVPIEHPEYEWFARL
                     GVRWYAVPVISGMRLEIGGVRYPLAPFNGWYMGTEIGARNLADTDRYNLLPDIARRLGL
                     DTSHDRSLWKDRALVELNLAVLHSFEKAGVTISDHHTESRHFLTHIAREERAGRTVGAD
                     WSWIVPPVSGAATPVFHRYYDTEQRYPAFVDQPKAPADSGPAARPPGRDF"
     source          1..11423
                     /country="China"
                     /db_xref="taxon:1650571"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces pathocidini"
                     /strain="CGMCC4.1633"
                     /type_material="type strain of Streptomyces pathocidini"
     misc_feature    1..11423
                     /note="8-azg biosynthetic gene cluster"
     subregion       1..11423
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002508"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11423
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(1170..2396)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184:major
                     facilitator transporter (Score: 121.7; E-value: 4.8e-37)"
                     /gene_kind="transport"
                     /note="MFS transporter"
                     /product="8-AzgB"
                     /protein_id="QLM04709.1"
                     /transl_table=11
                     /translation="MTTPLTPHPTRQRPAPVLGRGVVLLLTVGTGLSVANNYYVQPLLG
                     DIGRDLGLPEGQAGLLVTVGQSAYAVALLLVLPLGDLLERRRLIVILSSACAVSLVLMA
                     SARSEPALFLGAGLVGLCSVTTQVMVPYAASLSAPDQRGRVVGTVMAGLLCGILFARTV
                     AGALAQWAGWHAVYWCAAVMMACLAATAAVFLPRYQERGAPGYRHLVASVFHLFAREPV
                     LRLRAVYGALSFGAFSVLWTALTFLLSAPPYGYSPGVIGLFGLFGLAGALAAARAGRLA
                     DRGLAHKVTGVSSVLLLAVWIPLGLGSALLPALALGIVVLDLAAQALHITNQSEIYRLA
                     PEIRSRLTAAYMTTYFLAGAAGSALASLAYARLGWTGVSVLGAALGAATTSLWAISALR
                     QRSRHRRTP"
     CDS             complement(2417..3127)
                     /codon_start=1
                     /note="ADP-ribose pyrophosphatase"
                     /product="8-AzgC"
                     /protein_id="QLM04710.1"
                     /transl_table=11
                     /translation="MLAHDGDNWHILLVRRGKEPFQGRWALPGGKVGADEDATTAARRE
                     LQEETGLRATDTELIPLSWRTSPDRDPRGRYVSLVYAALLPQPQQVHGGGDAAAAWWQP
                     LPVPPRGFPDPAAEQHFAFDHAAILRELLPAAPHGRSAVPHIREATAADGQEIRRLLKS
                     HALGDGAAGHPATGGLGPRTHVAALGSFLVGCAGLPPNGDPAAKDRILVHPRWQGRGIE
                     QELAAVQAQEHRPP"
     CDS             complement(3192..3695)
                     /codon_start=1
                     /note="nucleotide monophosphate nucleosidase"
                     /product="8-AzgD"
                     /protein_id="QLM04718.1"
                     /transl_table=11
                     /translation="MEKWPDILIAVVGKGRNCPPPVYQLAHEVGGTVARLPDCLLVTGG
                     LGGAMEAAARGAKENGGRVLSLLPGVSNRTTQPHTEVDIRLDTGLTANGRNIVLASVVN
                     AMIAVPGSHGALQEMIVAVDAGKTVWAVGEHTTRLPGVEYLASSGELSARLHAFTAAST
                     SDLG"
     CDS             complement(3702..4010)
                     /codon_start=1
                     /note="hypothetical protein"
                     /product="8-AzgE"
                     /protein_id="QLM04711.1"
                     /transl_table=11
                     /translation="MADEDVGRLADQMRQALHTCSVHTVGPLAAYERCTAALDQGRIDA
                     QQFQEIGRRLVAISEERMHAYAAQGEHPDNSPKIRREKRLIGFVDALFALGLRKKKN"
     CDS             complement(4047..4667)
                     /codon_start=1
                     /note="GTP cyclohydrolase I"
                     /product="8-AzgF"
                     /protein_id="QLM04712.1"
                     /transl_table=11
                     /translation="MAESQQPHLPLPPKPVDVDVIENAISELLRGLGQGDKSEVMSQTP
                     RRVAELYAQSINPGDIDIEEDFKVFDNPGMQDLILVNDVHYVSLCEHHLAPAFGVAHVG
                     YVPDRKVAGYSKLKKGLNYLARQPQLNERLVVDAVNFLEARLQPKGIAMVLRSAHCCIA
                     LRTNAPSQEVVTVIERRGALCEERYWSPLWASAVAEKPAFLGR"
     misc_feature    complement(4641..4643)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(4903..6291)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /note="Oxygen-independent coproporphyrinogen-III
                     oxidase-like protein"
                     /product="8-AzgG"
                     /protein_id="QLM04713.1"
                     /sec_met_domain="PF04055 (E-value: 1.8e-17, bitscore: 53.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAASAPIQLASGRLVLPQTPYQQYVYAYPHQKAYRRLENGPLLSE
                     LWRNEQLDSLSLYVHIPFCEMRCGFCNLFTRTGAPEDVTSAFLDTLGRQARVTREATDA
                     SGRPVRFLMSAFGGGTPTYLTPVELTRLCDICENVMGADLRAIPWSVETSPATATADRL
                     AVLAERGATRLSIGVQSFIDEEARAAVRPQKRAEVETALARLREAGFPVLNIDLIYGIG
                     GQTERSFRISLDAALAWEPEEIYLYPLYVRPLTGLSTRHDKDGRLWDEQRLRLYRYGRD
                     YLLAAGYEQTSMRVFRRLGTPAGAPGEDASIDEYNQQAGMVGLGVGARSFTTSLHYTTD
                     YAVAVPEVRRIIDDYIATPSEEFRRAQWAFRMDDGERRRMYVLQRLLETVGLPVTDYRK
                     LFGTAPQDDFATEFALLRERQWLAADENTALKLTREGMAWADAIGPLFFSPLVNEAMAS
                     YQDK"
     misc_feature    complement(6166..6168)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(6250..6252)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             6461..7597
                     /codon_start=1
                     /note="DUF1152 domain-containing protein"
                     /product="8-AzgH"
                     /protein_id="QLM04714.1"
                     /transl_table=11
                     /translation="MTAKLLIAAGGGGDAITTAMVHAALHGDDAPALILTYAWERLVVD
                     PVPGPRRRTDFTGTERVGDQVHLITPGSAPIPPAGSLLPRLAADLRPALGLIDPYEGTV
                     GLALQIAQAAEYCGADRVEIVDVGGDVAADGSEPTLRSPLGDALVVAACLRTGIPAAVH
                     IAGPGLDSEVPEAVLLPRLGLPEFTLTAAHTNCVGNVFDWHPSEASALLVAAARGIRGV
                     CGTRDAPDPVVLSPASAHVYRLPLARVLEINRLAQALDGTADLAEAEEASRSVCGFSEV
                     ARERERARQRCAARGSTRREGGAPDAASPYQRFVEWEQRTAATGIQYVTTRRFAEELGL
                     SQGALTALRNQLKNTAPARSAPPLWQLHSDGQLTREKS"
     CDS             7863..9911
                     /codon_start=1
                     /note="hypothetical protein"
                     /product="8-AzgI"
                     /protein_id="QLM04715.1"
                     /transl_table=11
                     /translation="MNSAREAARNQGIDPANYDYLFVDITKHTGCNWGAQGSMPGNWIV
                     SNAEGHKSWMWMHEFGHNLGFNHPLTLRGCPVSGDVTRINGSCTQGATDDPGDPVGGGG
                     KRLYPASYRQYAGWLSGSQMIPIRTSGSYQLGVLGKDGVQEYRIDRGNGSTLSLEFRRP
                     KPPYDDFASDDPLVNGVTVRIVSGDGRHNTLVDATPATSSTKDAPLAAGKILVDEVAKA
                     AVRVCSVGDNGADLRVAIGDTSPADCKDTEELTAPTVAKAEITGVRQSTGEVVRDISGT
                     GVPGAIVQFLRNDGRWENNMATVEADGTWSRINTVYGADDGVTVRQTKDGETSDASPKK
                     SYTIAKPTIALAEIRVNGANSELSYHAAGKGVPGARIQVANASGGWTDRNVVGGDGSWS
                     FSGGYGNAFARVRQVLDGITSAASDDGEWKVPTPTISSAQITGVDGSGKTQYALEGTGL
                     AHTTVQIRNGSSWVDSVKVGQDGKWSVAKSTATQDTSGAVVRVAGSIGGVTHYSAASAK
                     KSYTIAKPTITSPGDGATVQASFTAHGKGVSGAQVSAKIEGVTKSVTVNANGDWTVDFT
                     GVAGGKQELSVSQSRDGLVSPAERRNITVAGSAPGTPPSSCGGAPAWDSSKIYWGGDLV
                     FDVTDVNNPSAGYTVYRAAWWNVNVRPVTNNGPWGKEWILVGTCQAP"
     CDS             10045..10356
                     /codon_start=1
                     /note="hypothetical protein"
                     /product="8-AzgJ"
                     /protein_id="QLM04716.1"
                     /transl_table=11
                     /translation="MVVCGPARIPLEEINDLRRRMMGVATQESSNVPRFSSLGVGGSRV
                     DHTMLLCMPEKTSPESSLHGSADLSVVPVSPGVDDWIPSADELVQAIVEVMNQRCRTN"
     CDS             10590..11423
                     /codon_start=1
                     /note="glycosyltransferase"
                     /product="8-AzgK"
                     /protein_id="QLM04717.1"
                     /transl_table=11
                     /translation="MPASLPLHPASGTRAQSAAVIDSSAPRVLIAVDAYPSDSREAAHF
                     TRQLISELAAKGHEVHLVCPSDRGRPRVERVDGVIVYRLRSLPALMQPTRRVVMRLGLR
                     TCVERLIDRIAPDVLHVQSHSVIGRAVAGAARRAGLPVVADTSHRLLQRVRAGQGLRLD
                     AKPVTRGVDPAHVRPSGTLTEGTRARFRLPCRDKVPGARRQSSSWARLSVAGLGLALAM
                     LATVHVPGNRDPIRDVISYYAFDSATVWPYYSWRAVACDRHVRLGHRPPPAAAAG"
ORIGIN
        1 tcaaaagtcg cgcccaggcg ggcgcgccgc aggccctgag tcggccggtg ccttcggttg
       61 gtcgacaaac gccgggtagc gctgctcggt gtcgtagtag cggtggaaca cgggggttgc
      121 ggcgccggag acgggtggca cgatccacga ccagtcggcg ccgacggtcc gcccggctcg
      181 ttcctcgcga gcgatgtgcg tcaggaagtg gcgcgattcg gtgtggtgat cgctgatggt
      241 gactcctgcc ttctcaaagg agtggagcac ggcgaggttc agctccacca gtgcgcggtc
      301 cttccacaac gagcggtcgt gggaagtgtc caggcccagt cggcgggcga tatcgggcag
      361 caggttgtag cggtcggtgt cagccaggtt gcgggcaccg atctccgtgc ccatgtacca
      421 gccgttgaaa ggggcgagcg ggtagcgtac gccgccgatt tccagtcgca tcccggagat
      481 gaccggcacc gcgtaccagc gcacacccag ccgggcgaac cactcgtact cggggtgttc
      541 gatcggaacc tggagcacgg cggagtccgg caggtcgaac caccgcggct tgtcgtcgcg
      601 cccgtgcacg atgagaggca ggacatcgaa gggagtgccc gggccgccgg gccagcccag
      661 attctgcgcg gcggccgtga tatcgacgct gaccgggtcg ccgaggatcg aaccgtcgga
      721 gcgtgtgtag cccgcgtagc gcacgagctg gtcgttccat atccgcgggg ccggccgccg
      781 ggggagctcc ggggcgaaga cggtgacgca cggacgtatt cgtccgccgt tggtggcctg
      841 gcacaggtgc cggacgattt cccgagagat ctggtcggcg ctgtccacct tccgccggtc
      901 gcgcacgatc agcgactgcc agtacagacg gccgatgcag cggatgctgt tgcgccaggc
      961 gaccttggcg ccgaagtcca gttcctgcgc cgtgtgcgtg tacgtcccgg tgcgcgagat
     1021 ctctgcggcc acctcggcca gtctccggtc cgcggaaccg gcctcgggac gctcgcggtg
     1081 atacaaggtc acgaactcct ccgccagcgc ccggaccgct tccggtcctg cggaggcggt
     1141 gtcggagtgg cagcgctcct cctccggact cacggggttc gcctgtgccg ggagcgttgg
     1201 cggagcgccg agatcgccca cagtgaggtc gtcgccgccc cgagtgccgc cccgagcacc
     1261 gagaccccgg tccagccgag ccgggcgtag gccagggagg cgagcgccga ccctgcggct
     1321 ccggccagga agtacgtcgt catgtaggcc gcggtgagac gggacctgat ctccggcgcc
     1381 aaacggtaga tctcgctctg gttggtgatg tgcagggctt gagccgcgag atcgagcacc
     1441 acgatgccca gggccagggc cggcagcagt gcgctgccca gcccgagggg gatccacacg
     1501 gcgagcagca gtacggagga gacaccggtc accttgtgtg ccagtccccg gtccgcgagg
     1561 cgcccggcgc gtgccgcggc cagcgccccg gccaggccga acaggccgaa caggccgatg
     1621 accccgggcg agtagccgta cggcggggcg gagagcagga aggtcagggc ggtccacagc
     1681 acgctgaagg ccccgaacga cagtgccccg tacaccgccc gcagccgtag caccggttcc
     1741 cgggcgaaca ggtggaacac cgaggccacg aggtgccggt agccgggagc gcccctctcc
     1801 tgataccggg gcaggaagac cgccgccgtt gccgccagac aggccatcat gaccgcggcg
     1861 caccagtaga cggcgtgcca cccggcccac tgcgccagcg caccggccac ggtacgggcg
     1921 aacaggatgc cgcacagcag ccccgccatg acggtgccca cgacgcgccc gcgctgatca
     1981 ggagcggaca gggacgcggc atagggcacc atcacctggg tggtgacgga gcacagcccc
     2041 accagtcctg ctcccaggaa gagggccggc tccgatcggg cgctggccat gagcaccagg
     2101 ctcacggcgc aggccgagga caggatgacg atcagccggc gccgttcgag caggtcgccg
     2161 aggggaagga cgaggagcag tgccaccgcg taggcgctct gtcccaccgt gaccagcagg
     2221 ccggcctgtc cttccggcag gccgaggtcg cggccgatgt cgccgagcag cggctgcacg
     2281 tagtagttgt tggccacgga caacccggtg ccgacggtga gcagcaagac cacgccgcgt
     2341 cccagaacgg gcgccgggcg ttgtcgcgtg gggtgtggtg tgagcggtgt ggtcatggcc
     2401 gctttccttt tacgagtcac ggtgggcggt gctcctgagc ctgtacggcg gccagttcct
     2461 gctcgatccc ccgcccctgc cagcgggggt ggaccaggat ccggtccttc gctgccgggt
     2521 caccgttcgg cggcaggccc gcacagccca cgaggaagct ccccagtgcc gctacgtgcg
     2581 tccgggggcc gaggcccccg gtggccgggt ggccggcggc gccgtcgccc agggcgtgtg
     2641 acttcagcag gcgccggatc tcctggccgt ccgccgcggt cgcctccctg atgtgcggga
     2701 cggccgaccg gccgtgtggt gcggcgggaa gcaactcccg gaggatggcg gcatggtcga
     2761 aggcgaagtg ctgctccgct gcggggtccg ggaagccgcg cggggggacg ggcagcggct
     2821 gccaccacgc cgccgctgcg tccccgccgc cgtgcacctg ctgcggctgc ggcagcagcg
     2881 ccgcgtagac caggcttacg tagcgtcctc tggggtcgcg gtccggtgag gtgcgccagg
     2941 acagcggaat gagttcggtg tcggtggcgc gcagcccggt ttcttcctgt agttcgcggc
     3001 gggccgcagt tgtcgcgtcc tcgtcggcgc cgacctttcc gccgggaagc gcccaccggc
     3061 cctggaacgg ttccttgccc ctgcgaacca gcaggatgtg ccagttgtca ccgtcgtggg
     3121 ccagcatcac caggtcgacg gtcaggatga cggcgctcag cgggcactcc ttgtggttgt
     3181 ccgcacgccg gctacccgag atcagaggtg gaggcggcgg tgaaagcgtg caggcgcgcg
     3241 gagagttcgc ccgaggacgc gaggtactcc acccccggga ggcgggtggt gtgctcgccc
     3301 actgcccata cggtcttgcc ggcgtcgacg gccacgatca tctcctggag ggctccgtgc
     3361 gagcccggga cagcgatcat ggcgttgacg acgctggcca gcacgatgtt gcggccgttg
     3421 gcggtcagac cggtgtccag ccggatatcc acctcggtgt gcggctgggt cgtgcggttc
     3481 gagacacctg gaagcaggct cagcacgcgg cctccgttct cctttgcacc gcgagccgct
     3541 gcttccatcg ctcctccgag cccaccggtc accagaaggc agtcgggcag ccgtgcgacg
     3601 gtccctccca cctcgtgggc caactggtac accggtggtg ggcagttgcg tcccttgccg
     3661 accacggcga tgaggatatc cggccatttc tccatggggc ctcagttctt cttcttgcgc
     3721 aggccgaggg cgaagagcgc gtcgacgaag ccgatcagcc gcttctcccg cctgatcttc
     3781 ggcgagttgt cggggtgctc tccctgagcg gcgtacgcgt gcatgcgttc ttcggagatg
     3841 gcgaccagcc tgcggccgat ctcctggaac tgctgcgcgt cgatgcgccc ttggtcgagg
     3901 gcggcagtgc atctctcgta cgccgccaag gggcccacgg tatggacaga acaggtgtgc
     3961 agtgcctgtc gcatctggtc ggcgagccgg cccacgtctt cgtcggccac ggacgccgac
     4021 ggtgctcctc ggtccattcg gctcgcctat ctccccagga aggccggttt ctccgcgacg
     4081 gcactggccc acagcggcga ccagtagcgc tcctcgcaca gtgcgccgcg ccgctcgatc
     4141 accgtgacga cttcctggct cggggcattg gtgcgcagcg cgatgcagca gtgcgcactg
     4201 cgcaggacca tggcgattcc cttcggctgc agccgcgcct ccaggaagtt caccgcatcg
     4261 accaccaggc gctcgttgag ctgaggctga cgcgcgaggt agttcagccc cttcttgagc
     4321 ttggagtagc cggccacttt gcggtcggga acatatccga catgggcgac cccgaaggcg
     4381 ggcgccagat ggtgttcgca cagcgagacg tagtgcacgt cgttgaccag gatcaggtcc
     4441 tgcattccgg ggttgtcgaa gaccttgaag tcctcttcga tgtcgatgtc gcccggattg
     4501 atcgactggg catacaactc cgccacccgg cgcggagtct gcgacatcac ctcgctcttg
     4561 tcaccctggc cgagaccgcg cagcagttcg ctgatggcgt tctcgatcac gtccacgtcc
     4621 accggcttgg ggggaagcgg taaatgaggt tgctgggatt cagccatggt gtcatcctcc
     4681 aggtctttgg gcccgctttg tgggcggaac tctccaggac gcgtctttta gagtctgcac
     4741 ggaacgatcg tttggcagag gctagaaacc ggatgggagc gagtcaaccg gtgagcagcg
     4801 aaaacacgcc aggtgttcgt gtggtgcccg cgcacggaaa ttccccgatg gcacaggcca
     4861 tttcgtggcc tctccgtgcg cggggcaccg gggttcgctg cgctacttgt cctggtagct
     4921 cgccatggct tcgttgacca ggggggagaa gaagagcggg ccgatcgcat ccgcccaggc
     4981 catcccctcc cgggtgagtt tcagcgcggt gttctcgtcg gcggcgagcc actgcctttc
     5041 gcggagcagg gcgaactctg tcgcgaagtc gtcctggggc gccgtaccga acagcttccg
     5101 gtagtcggtg accggcaggc cgacggtctc cagcagccgc tgcaggacat acatccggcg
     5161 ccgttccccg tcgtccatcc ggaaggccca ctgggcccgg cggaactctt cggagggggt
     5221 ggcgatgtag tcgtcgatga tgcgccgcac ttcgggcacg gccaccgcgt aatcggtggt
     5281 gtagtgcagg gaagtggtga acgaacgggc gccgacgccg agtcccacca tgccggcctg
     5341 ctggttgtac tcgtcgatgc tcgcgtcttc ccccggggcg ccggcgggtg tccccagccg
     5401 tcggaagacc cgcatcgagg tctgctcgta gccggcggcc agcaggtagt cgcggccgta
     5461 ccggtacagg cgcaggcgtt gctcgtccca cagcctgccg tccttgtcgt gccgggtgct
     5521 cagaccggtc aaggggcgta cgtagagcgg gtacaggtag atctcctccg gctcccaggc
     5581 cagcgcggca tcgagggaga tacggaagga gcgctctgtc tggccgccga tgccgtagat
     5641 gaggtcgatg ttcaagacgg ggaagccggc ctcgcgcagc cgggccaggg ccgtctccac
     5701 ctccgcgcgt ttctgcggtc gtacggcggc gcgggcttcc tcgtcgatga agctctgtac
     5761 accgatgctc agccgggtgg cgccgcgctc ggcgagcacc gcgagccggt cggcggtcgc
     5821 ggtggccgga gaggtctcca ccgaccaggg gatggctctg aggtctgccc ccatcacgtt
     5881 ctcgcagatg tcgcagagcc gggtgagctc tacgggggtg agataggtgg gggtgccgcc
     5941 gccgaaggcg gacatcagga agcgaaccgg ccgcccgctt gcgtctgtcg cttcacgggt
     6001 cacccgcgct tgccgtccca gcgtgtccag aaacgcgctg gtgacgtctt ccggggcgcc
     6061 ggtacgggtg aacagattgc agaatccgca gcgcatctcg cagaacggta tgtgcacgta
     6121 gagcgagagg gagtcaagct gctcgttcct ccacaactcg ctcagtaacg gcccgttctc
     6181 cagccgccgg taggcttttt gatggggata ggcgtagacg tactgctggt agggagtctg
     6241 cggcaaaact aatctgcccg aggccagttg gatgggggca gaggcggcca tggacaacac
     6301 cttccctctc ttgacaaggg agctgaagta cgactctgcg gacacggtag cggtcaggta
     6361 cacgcatacg taagcatggc gggccacctc tcggagtggc ccgggcattt tcggtcagtg
     6421 gacggacgga caccgggaac gacccagggg gtcaaggcat ttgactgcga aacttctgat
     6481 tgccgccgga ggcggcgggg acgcgatcac caccgcgatg gtccacgcgg ctctgcacgg
     6541 tgacgacgct cccgccctca tcctgaccta tgcctgggaa cgcctggtgg tcgatccggt
     6601 acccggcccc agacgccgca cggacttcac cggcaccgaa cgcgtcggtg accaggtgca
     6661 cctgatcacg cccgggtcgg cccccatccc tcccgcgggc tcactgctgc ctcggctcgc
     6721 ggccgacctg cggcccgcgc tcggcctcat cgacccgtac gagggcacgg tgggcctggc
     6781 cctccagatc gcccaagccg ccgaatactg cggcgccgac cgcgtcgaaa tcgtcgacgt
     6841 cggcggggac gtggcggccg acggcagcga acccaccctg cgcagcccgc tgggcgacgc
     6901 gctcgtcgtg gcggcgtgcc tgcgcaccgg tataccggcc gcggtgcaca tcgccggccc
     6961 cggactcgac tccgaggtgc ccgaagccgt actgctgccc cgcctgggcc tcccggagtt
     7021 caccctcacc gccgcacaca cgaactgcgt cggcaacgtc ttcgactggc acccctccga
     7081 ggcgagcgcc ctcctggtgg ccgcggcccg cggcatacgg ggtgtctgcg gtacccgcga
     7141 cgcgccggac ccggtcgtgc tcagccccgc cagcgcacac gtctaccggc tccccttggc
     7201 ccgtgtcctg gagatcaacc ggctggccca ggcgctcgac ggcactgccg acctggcgga
     7261 agccgaggaa gccagccgct cggtgtgcgg tttctccgag gtcgcccgcg agcgcgagcg
     7321 cgcccgtcag cggtgtgcgg cgcgaggcag tacgcggcga gagggcggtg caccggacgc
     7381 cgcctccccc taccagcggt tcgtcgagtg ggagcagcgc accgcggcca ccggcatcca
     7441 gtacgtcacc acccgccggt tcgccgagga actgggcctc tcccagggcg cactgacggc
     7501 cctccgcaac cagctgaaga acaccgctcc cgcgcgctcc gcaccacctc tgtggcagct
     7561 gcactccgat ggacagctca cccgggagaa gagctgaagc cggcgacgcc cacaggcgca
     7621 agatccccga gaagtccaac gaatgccgcc gcaccttccc tgacccgctc gactcgtaac
     7681 tttagtcagc ccagttcctt acttcctgca tggctcgtgg cggaaacgac ctcttaggct
     7741 tgtggggatc ccggtctgac gcagagaatc aacctgccat ttcgcgagaa gtcctccgcg
     7801 tctccagagc tcgtttcgaa aggctcggcg ccaggccgag cgactgcaaa tcggattcga
     7861 tattgaattc agcgcgagaa gcggcgcgaa atcaggggat agaccccgcg aactacgact
     7921 acctttttgt tgatatcacg aagcacaccg gatgcaattg gggtgcccag ggttccatgc
     7981 ccggaaactg gatcgtgtcc aacgccgagg gccacaagtc gtggatgtgg atgcacgagt
     8041 tcggacacaa tctcggattc aaccaccctc ttacgctacg gggctgccct gtgtcggggg
     8101 acgtgacgcg gatcaacggc agctgtaccc aaggagcgac tgacgatccg ggagaccccg
     8161 tgggcggtgg cggcaagcga ctctacccgg ccagttaccg gcagtacgcg ggctggctct
     8221 ccggttccca gatgatcccg atccgcacca gcgggtcgta ccagctgggc gtcctgggga
     8281 aggacggtgt ccaggagtac cggatcgacc ggggcaacgg ctccactctg tcactggaat
     8341 tccgtcgccc caagccgccc tatgacgact ttgcctcgga cgacccgctg gtgaacggcg
     8401 tcaccgtgcg tatcgtcagc ggggacggca ggcacaacac gctcgtcgac gccactcccg
     8461 caacgtcgag caccaaggac gcccccctgg cggcgggcaa gatcctggtg gacgaggtcg
     8521 ccaaggcggc cgtccgggtc tgctcggtgg gcgacaacgg cgctgacctc agggttgcca
     8581 tcggtgacac ctcgcccgcc gactgcaaag acacggagga gctgacggct ccgaccgtgg
     8641 ccaaggccga gatcaccggg gtccgtcagt ccacgggtga ggtggtccgc gacatttccg
     8701 gcactggtgt gccgggggcg atcgtgcagt tcctgcggaa cgatggcagg tgggagaaca
     8761 acatggccac ggtcgaggcc gatggcacct ggtcgcggat caacactgtc tacggtgccg
     8821 atgatggcgt gacggttcgg cagaccaagg atggtgagac gtccgacgcc tccccgaaga
     8881 agtcctacac gattgccaag ccgacgatcg ccctggcgga aatccgagtg aatggtgcga
     8941 actccgagct ctcctatcac gctgccggca agggagtgcc aggtgctcga atccaggtag
     9001 cgaacgcgtc cggcggctgg acagaccgca acgttgtcgg cggagacggc tcctggtcat
     9061 tctctggcgg gtacggtaac gcttttgcac gcgtccggca ggtgctcgac ggcatcacat
     9121 cagccgcttc ggatgatggg gagtggaagg tcccgacccc gacgatctcc tccgctcaga
     9181 tcacgggcgt ggacgggagc ggcaagacgc agtacgcgct ggaaggcacc ggtctggcac
     9241 ataccacggt gcagatcagg aatggttctt cctgggtgga ctcggtgaag gtgggtcagg
     9301 acggcaagtg gtcggtagcc aagtccaccg cgacgcaaga cacctccggt gcggtggtgc
     9361 gtgtcgcggg cagcatcggc ggcgtcaccc actactcggc ggcttccgcg aagaagtcct
     9421 acacgattgc caagccaacc attacctcgc ccggtgatgg agccacggtg caggcctcgt
     9481 tcaccgcaca tggcaagggc gtatccggtg cccaggtctc ggccaagatc gaaggcgtga
     9541 ccaagagcgt gaccgtgaac gcgaacggcg actggacagt cgacttcact ggcgtggccg
     9601 ggggcaagca ggagctgtcc gtctcccagt cgcgtgatgg cctggtctcc ccggcagagc
     9661 ggcgcaacat cacggttgcg ggctcggccc cggggacgcc gccctcctct tgtgggggtg
     9721 ccccggcctg ggattcctcc aagatttact ggggcggtga cctcgtgttc gacgtgaccg
     9781 acgtcaacaa tccgtcggcg ggatacaccg tctaccgggc tgcttggtgg aacgtgaatg
     9841 tccgcccagt gaccaacaac ggcccctggg gcaaggagtg gatcctggta ggcacctgcc
     9901 aggctccctg acgcgagaac gctccggccc tcactggagc ccgtgactgc agtccagtca
     9961 cgggctccgg tgcgcctcac tcggcgtggg tgcgggcgcg ggtcgtcgaa caggtcttgc
    10021 ccgaggcggg atcggagctt gtgggtggtg gtgtgcggtc cggctcggat acccctggaa
    10081 gagatcaacg acctgcgtcg tcgaatgatg ggagtggcca ctcaagagtc ttccaacgtc
    10141 cctcgatttt catctttggg cgtcggaggg agccgagtcg atcacaccat gctcttgtgc
    10201 atgcccgaga aaacctcgcc cgagtcaagc ctgcacggtt ccgctgatct atccgtcgtg
    10261 ccggtgagcc ctggcgtcga tgattggatt ccgtcggccg acgaactcgt ccaggccatc
    10321 gtggaggtca tgaaccagcg gtgccggacg aattgaacag ccatcattcg tcgtttgccg
    10381 aatatccggt gtgagaccgc cgggcagacg tccgccgttg catgagccgc gttcgtcgcc
    10441 cccatggcgc ctaccacaga tggttgcagc aagcgggcac ggcatgagct tgctcgcctg
    10501 acttctcttg cagtcgtcca ggttcccggg cgcgcagtcc accggagagc tcatcagagt
    10561 ccgacgccgc tgcaggcaag aggagtccca tgcccgcgtc ccttccgctg caccctgcct
    10621 ccggcacccg cgcacagtct gccgcggtga tcgacagctc ggctccccgc gtactgatcg
    10681 ccgtcgacgc ctatccgtcg gactcccgcg aggccgccca tttcactcgc caactgatct
    10741 ccgaactggc ggcgaagggg catgaggtgc atctcgtgtg cccgtcggat cggggccgtc
    10801 cgagggtgga gcgagtggac ggcgtcatcg tctaccgtct gcgctccctg cctgcgctga
    10861 tgcagccaac acgacgagtg gtcatgcgtc ttgggctgcg tacctgtgtc gagcggctga
    10921 tcgaccggat tgctcccgat gtgctgcatg tgcagagcca ctccgtgatc ggccgggccg
    10981 tggccggcgc cgcacggcgt gcggggctgc ccgtggtggc ggacaccagc catcgcctgt
    11041 tgcagcgggt gcgggcagga caagggctcc gcctcgacgc caagcccgtc acccgcggcg
    11101 tcgacccggc tcacgtccgc ccttctggca cactcacgga gggaactcgc gcccgtttcc
    11161 gcctgccctg tcgggacaag gtgccggggg cgcggcggca gtcgtcgtca tgggccaggc
    11221 tctccgtcgc cgggctcggg ttggccctgg ccatgctggc caccgtgcac gtgccgggca
    11281 accgggaccc gatccgtgac gtcatcagct actacgcctt cgactcggcg accgtctggc
    11341 cgtactacag ttggcgggct gtcgcttgcg accggcacgt tcgccttggg catcgccctc
    11401 caccggctgc tgccgcgggg tag
//
