LOCUS       BGC0002515             32340 bp    DNA     linear   PLN 03-DEC-2020
DEFINITION  Ascochyta rabiei isolate Me14 Arab_Me14_ctg07, whole genome shotgun
            sequence.
ACCESSION   BGC0002515
VERSION     BGC0002515
KEYWORDS    .
SOURCE      Ascochyta rabiei (Didymella rabiei)
  ORGANISM  Ascochyta rabiei
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
            Didymellaceae; Ascochyta.
COMMENT     Illumina sequencing data were used for correction and polishing of
            the WGS PacBio sequence assembly presented here. Sequence authors
            for the  Ascochyta rabiei ME14 Illumina sequencing project are:
            Ramisah M. Shah, Angela H. Williams, Julie A. Lawrence, James K.
            Hane, Robert A. Syme, Judith Lichtenzveig
            Annotation was added to the contigs on December 2020.
            This WGS project has been superceded by the complete genome in
            (non-WGS) GenBank records CP095288, CP095289, CP095290, CP095291,
            CP095292, CP095293, CP095294, CP095295, CP095296, CP095297,
            CP095298, CP095299, CP095300, CP095301, CP095302, CP095303,
            CP095304, CP095305, CP095306, CP095307, CP095308, CP095309,
            CP095310.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:53:05
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 32340
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(join(1..960,1015..7378,7465..7936,7989..8055))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (16-440). E-value:
                     2.6e-159. Score: 522.5. Matches aSDomain:
                     nrpspksdomains_EKO05_004940_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (599-914). E-value: 4.9e-87.
                     Score: 283.9. Matches aSDomain:
                     nrpspksdomains_EKO05_004940_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (990-1167). E-value: 1.1e-27.
                     Score: 89.3. Matches aSDomain:
                     nrpspksdomains_EKO05_004940_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1437-1647). E-value: 1.4e-60.
                     Score: 196.4. Matches aSDomain:
                     nrpspksdomains_EKO05_004940_cMT.1"
                     /NRPS_PKS="Domain: PKS_ER (1874-2186). E-value: 1.6e-84.
                     Score: 275.6. Matches aSDomain:
                     nrpspksdomains_EKO05_004940_PKS_ER.1"
                     /NRPS_PKS="Domain: PKS_KR (2210-2388). E-value: 1.3e-46.
                     Score: 150.7. Matches aSDomain:
                     nrpspksdomains_EKO05_004940_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2537-2605). E-value: 7.7e-14.
                     Score: 43.7. Matches aSDomain:
                     nrpspksdomains_EKO05_004940_PKS_PP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 227.7; E-value:
                     4.3e-69)"
                     /gene_kind="biosynthetic"
                     /locus_tag="EKO05_004940"
                     /product="hypothetical protein"
                     /protein_id="KAF9708863.1"
                     /sec_met_domain="itr_KS (E-value: 5.4e-165, bitscore:
                     537.6, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.4e-88, bitscore: 283.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_N (E-value: 2.9e-08, bitscore: 22.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 7.1e-17, bitscore:
                     50.1, seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 9.1e-42, bitscore:
                     131.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.9e-09, bitscore:
                     25.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSQYGTNGTSADPEPIAIVGMGCRWPGGVRDASGLWELLKNKRS
                     GYREFGDHRFSRKGFHHPNSEHPGTVATKGGFLLAEDPRLFDHAFFGIGSLEVETMDPS
                     QRKLLEVVYEAFENSGEPWDSFSGSTTGVFVGNFSSDHLIIQGRDTDHPRPYASVGTGT
                     SILSNRINYIFNLRGPSVTIDTACSSSMYALHLAISAIRNGDCDSAIVAASNTIIDPST
                     QLMMTKLGVLSPTSTSHTFDSSADGYARGEGFSALYLKRTSTAVDGDYPIRALVRGSAL
                     NANGRTGGITHPGREGQEAVIRKAYENAGNLPMKDTTFFECHGTGTPVGDPIEISAIGN
                     VFGSATTPEKPLLVGSIKTNIGHTEPASAIAGIMKVVLALENGFIPPSIGIKKLNPNLD
                     LKGGRINILTENTPWPDGRVRRASVNSFGYGGANGHCIIDDVRNVLPDYKKRTANTSIG
                     HNNGHTNGHTNGTHASNGHNGHHQNGMNGNSASHLVEKADKVHYPFSYKPTLVKDINAK
                     PRRRVLIPFSAHNEASLDLNITAISEAIERENLADVAYTLAAKRSRFMQRTFRIVDSES
                     PANDFAVKEKVLASGTQTARLGFVFTGQGAQWHAMGADLFEYAVFRTSIEYLDSILASL
                     PTPSPWKIEDVLAGNCDPNDIHKPEVSQTVCTAVQIGLVDLLYTWNVRPSAVAGHSSGE
                     IAATYAAGRITAAQAIAAAYFRGQAVSKNKSKGLMLAVGLGLDKAEAYISGLESSVRIA
                     AVNSPDSVTLSGDESTIKDVAAKLNEDKVFSRELKTGGNAYHSHHMLALGEFYNSTLSE
                     GLDYVKSLGQAEPSQLYATRPWMSSVYPSKSTENLPVSPSYWRANLESPVRFSEALANM
                     LNLPDPLDVLVEIGPHPALKGPVGQISRSVDKSLPYFSTLNRGTNGGISLLQLAGSLFS
                     LNAEVDLTAVNAVDVISANQLKLVHGTTATNLPPYQYAYGPVIYHESRFSKEFRGRDIV
                     RHDLLGSKLPGNAKLRPQWRNILRLKDLPWLNDHKLLPYPVFPAAGYIATVIEAASRIY
                     NEQSEPLDITGYKLRNVTFSSAMRLPDDDFGLEIITSLELADAVNPKAPTWAMFSISSV
                     AREAGTWTEHCSGRVRVIAGTSVANEKMSTEMDARTLDTKAWYKKFAEIGLGYGPTFQP
                     LSNIRADPSKGLAVAQLALHTTRDTVEGGESNYPLHPASLDAVFQLSLVASHGGQIDRV
                     RNAFVPVHIDQLYVRNGVSQDSAVAIALGSMKGLRSAHAKLQVLDKSEQVALDVGNLRC
                     VTYTEVLPSTGVDKEAFSSPFLRLSWKPDIRAMDNEQVQRRFPPPTENVEKAYLFDKLE
                     RLGTLYVAEIHERYAGQGQFSSAPAHIDKFLSWVRRRMTDDNKWVAEANSLTSSQRGIL
                     IKELFAEVGHISDVKIANKVFNSMEDILSERKTGLEVVIQDNLLHGMYEDGLIMTGAYP
                     QLVRFFDLFGYANPNMRILEIGAGTGGATRKILKTLIEPHGIKRYQDYTFTDISSGFLA
                     QAREAFADFQDMKYSVLDIQENPLEHGYEAVYDVVVACECLHATPSIVKTLTNCRKLVK
                     PGGRLVVVENTRAVIGHGLVLGHLSGYWDGIPDGRVESPFLHLEGWNASLNQTGFAGAE
                     LVLDDYPSPYTTARTIVSSAVEEPAKVGQVPNGTVHLVHGDNKPELLSRIEHELTERGT
                     EFKVISIGDVETHLPDNSRTVAFADSKSLLVNASETHLKSFKALIRKSANLVWVTFGGI
                     VHGHDPDASITTGLLRTLGTENPTSQFLSIDVSPDSDFQEIRLTRTILDQELALSDRIA
                     GESRDYEFVWQEECLWVSRLVPDVALQDKLELSEGRPSRAEMLPLDSQGSVRAAFETPG
                     LLTSLYFKPYEETWKFLPDDWIQVKVAAVGLNWKDLLTSAGRFDMNTFSSEYSGVVAQV
                     GSNVTNVAVGDRVYGYGRGHFGNYVRAPANFAYRMLPGEDFVKMATIPLVGMTAIYSFE
                     CVTQLKEQERLLIQSATGGLGLSAIQLAKAKGAEIFATAGTQEKRRYLIDVAGIPASHV
                     FSSRDPADFAKLMEATDGKGFNVILSTSSGELLYDSIKMLAPMGRIIDVGRIDVQNSTS
                     LALELFKRNATFTSFDLAVADDADRALGPALMKTVNKRVRAGQMGPLSSITTYDVSQLD
                     QALMAFSKGTHVGKLVVTFQNPDALVKMVPAAPHAQFARNANYLITGGLGGLGRSIVNF
                     MAERGARHFTVLSRSRKINSEGQMLIDKLAASGTVVECVSCDVSDSKDVVRAVQDAAVV
                     RPIKGIVHAAVSYQDLSFDKLTIEQWTSALAAKVQGTKNLHEATKIHALDFFLMTTTIE
                     SFVALATQSAYTAANNFQDYFARWRRQQGLPASTVSFGLIRDVGHLSTNSTTLALMARN
                     KVMDISEYNFLRLLEPAFLNNESALDPAASTEPYTGAVDDPLSVTNVVTCFDPATMATR
                     KREEAAENNGNTGNSPRWYTDARVSLIMRAFDDAERYQASADGGDGGNERGNNAGVASL
                     RSEFEETVKAGPAERSKTVALVTDAIVKTVAQMLFVDASGVDASRTVADYGVDSLIAAE
                     LRNWFNVAFGADVSMLEMLDTATSMKILANKIVDGALA"
     subregion       1..32340
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002515"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..32340
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..28055
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:8055]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..8055
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..28055
                     /SMILES="C([*])C(-O)(C)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(1..8055)
                     /locus_tag="EKO05_004940"
     mRNA            complement(join(1..960,1015..7378,7465..7936,7989..8055))
                     /locus_tag="EKO05_004940"
                     /product="hypothetical protein"
     aSDomain        complement(49..252)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKO05_004940_PKS_PP.1"
                     /evalue="7.70E-14"
                     /label="EKO05_004940_PKS_PP.1"
                     /locus_tag="EKO05_004940"
                     /protein_end="2605"
                     /protein_start="2537"
                     /score="43.7"
                     /tool="antismash"
                     /translation="RSKTVALVTDAIVKTVAQMLFVDASGVDASRTVADYGVDSLIAAE
                     LRNWFNVAFGADVSMLEMLDTAT"
     aSModule        complement(49..8007)
                     /complete
                     /domains="nrpspksdomains_EKO05_004940_PKS_KS.1"
                     /domains="nrpspksdomains_EKO05_004940_PKS_AT.1"
                     /domains="nrpspksdomains_EKO05_004940_PKS_DH.1"
                     /domains="nrpspksdomains_EKO05_004940_cMT.1"
                     /domains="nrpspksdomains_EKO05_004940_PKS_ER.1"
                     /domains="nrpspksdomains_EKO05_004940_PKS_KR.1"
                     /domains="nrpspksdomains_EKO05_004940_PKS_PP.1"
                     /iterative
                     /locus_tags="EKO05_004940"
                     /monomer_pairings="pk -> Me-pk"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(700..960,1015..1287))
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKO05_004940_PKS_KR.1"
                     /evalue="1.30E-46"
                     /label="EKO05_004940_PKS_KR.1"
                     /locus_tag="EKO05_004940"
                     /protein_end="2388"
                     /protein_start="2210"
                     /score="150.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="NYLITGGLGGLGRSIVNFMAERGARHFTVLSRSRKINSEGQMLID
                     KLAASGTVVECVSCDVSDSKDVVRAVQDAAVVRPIKGIVHAAVSYQDLSFDKLTIEQWT
                     SALAAKVQGTKNLHEATKIHALDFFLMTTTIESFVALATQSAYTAANNFQDYFARWRRQ
                     QGLPASTVSFGLIRD"
     CDS_motif       complement(748..858)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0012"
                     /evalue="6.70E-12"
                     /label="PKSI-KR_m4"
                     /locus_tag="EKO05_004940"
                     /protein_end="2372"
                     /protein_start="2335"
                     /score="37.9"
                     /tool="antismash"
                     /translation="LDFFLMTTTIESFVALATQSAYTAANNFQDYFARWRR"
     CDS_motif       complement(1189..1284)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0011"
                     /evalue="5.40E-15"
                     /label="PKSI-KR_m1"
                     /locus_tag="EKO05_004940"
                     /protein_end="2243"
                     /protein_start="2211"
                     /score="47.9"
                     /tool="antismash"
                     /translation="YLITGGLGGLGRSIVNFMAERGARHFTVLSRS"
     aSDomain        complement(1360..2295)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKO05_004940_PKS_ER.1"
                     /evalue="1.60E-84"
                     /label="EKO05_004940_PKS_ER.1"
                     /locus_tag="EKO05_004940"
                     /protein_end="2186"
                     /protein_start="1874"
                     /score="275.6"
                     /tool="antismash"
                     /translation="LLTSLYFKPYEETWKFLPDDWIQVKVAAVGLNWKDLLTSAGRFDM
                     NTFSSEYSGVVAQVGSNVTNVAVGDRVYGYGRGHFGNYVRAPANFAYRMLPGEDFVKMA
                     TIPLVGMTAIYSFECVTQLKEQERLLIQSATGGLGLSAIQLAKAKGAEIFATAGTQEKR
                     RYLIDVAGIPASHVFSSRDPADFAKLMEATDGKGFNVILSTSSGELLYDSIKMLAPMGR
                     IIDVGRIDVQNSTSLALELFKRNATFTSFDLAVADDADRALGPALMKTVNKRVRAGQMG
                     PLSSITTYDVSQLDQALMAFSKGTHVGKLVV"
     CDS_motif       complement(1798..1848)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0010"
                     /evalue="1.80E-07"
                     /label="PKSI-ER_m6"
                     /locus_tag="EKO05_004940"
                     /protein_end="2040"
                     /protein_start="2023"
                     /score="23.5"
                     /tool="antismash"
                     /translation="GAEIFATAGTQEKRRYL"
     CDS_motif       complement(1858..1917)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0009"
                     /evalue="5.50E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="EKO05_004940"
                     /protein_end="2020"
                     /protein_start="2000"
                     /score="22.1"
                     /tool="antismash"
                     /translation="ERLLIQSATGGLGLSAIQLA"
     aSDomain        complement(2977..3606)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKO05_004940_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="1.40E-60"
                     /label="EKO05_004940_cMT.1"
                     /locus_tag="EKO05_004940"
                     /protein_end="1647"
                     /protein_start="1437"
                     /score="196.4"
                     /tool="antismash"
                     /translation="EVVIQDNLLHGMYEDGLIMTGAYPQLVRFFDLFGYANPNMRILEI
                     GAGTGGATRKILKTLIEPHGIKRYQDYTFTDISSGFLAQAREAFADFQDMKYSVLDIQE
                     NPLEHGYEAVYDVVVACECLHATPSIVKTLTNCRKLVKPGGRLVVVENTRAVIGHGLVL
                     GHLSGYWDGIPDGRVESPFLHLEGWNASLNQTGFAGAELVLDDYPSP"
     aSDomain        complement(4417..4947)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKO05_004940_PKS_DH.1"
                     /evalue="1.10E-27"
                     /label="EKO05_004940_PKS_DH.1"
                     /locus_tag="EKO05_004940"
                     /protein_end="1167"
                     /protein_start="990"
                     /score="89.3"
                     /tool="antismash"
                     /translation="HDLLGSKLPGNAKLRPQWRNILRLKDLPWLNDHKLLPYPVFPAAG
                     YIATVIEAASRIYNEQSEPLDITGYKLRNVTFSSAMRLPDDDFGLEIITSLELADAVNP
                     KAPTWAMFSISSVAREAGTWTEHCSGRVRVIAGTSVANEKMSTEMDARTLDTKAWYKKF
                     AEIGLGYGPTFQPL"
     CDS_motif       complement(4786..4863)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0008"
                     /evalue="4.80E-08"
                     /label="PKSI-DH_m2"
                     /locus_tag="EKO05_004940"
                     /protein_end="1044"
                     /protein_start="1018"
                     /score="25.5"
                     /tool="antismash"
                     /translation="WLNDHKLLPYPVFPAAGYIATVIEAA"
     aSDomain        complement(5176..6120)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKO05_004940_PKS_AT.1"
                     /evalue="4.90E-87"
                     /label="EKO05_004940_PKS_AT.1"
                     /locus_tag="EKO05_004940"
                     /protein_end="914"
                     /protein_start="599"
                     /score="283.9"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFTGQGAQWHAMGADLFEYAVFRTSIEYLDSILASLPTPSPWKIE
                     DVLAGNCDPNDIHKPEVSQTVCTAVQIGLVDLLYTWNVRPSAVAGHSSGEIAATYAAGR
                     ITAAQAIAAAYFRGQAVSKNKSKGLMLAVGLGLDKAEAYISGLESSVRIAAVNSPDSVT
                     LSGDESTIKDVAAKLNEDKVFSRELKTGGNAYHSHHMLALGEFYNSTLSEGLDYVKSLG
                     QAEPSQLYATRPWMSSVYPSKSTENLPVSPSYWRANLESPVRFSEALANMLNLPDPLDV
                     LVEIGPHPALKGPVGQISRSVDKSLPYFSTLNRG"
     CDS_motif       complement(5788..5874)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0007"
                     /evalue="3.60E-07"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="EKO05_004940"
                     /protein_end="710"
                     /protein_start="681"
                     /score="22.8"
                     /tool="antismash"
                     /translation="VRPSAVAGHSSGEIAATYAAGRITAAQAI"
     CDS_motif       complement(6073..6123)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0006"
                     /evalue="2.10E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="EKO05_004940"
                     /protein_end="615"
                     /protein_start="598"
                     /score="17.0"
                     /tool="antismash"
                     /translation="FVFTGQGAQWHAMGADL"
     aSDomain        complement(join(6598..7378,7465..7936,7989..8007))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKO05_004940_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.60E-159"
                     /label="EKO05_004940_PKS_KS.1"
                     /locus_tag="EKO05_004940"
                     /protein_end="440"
                     /protein_start="16"
                     /score="522.5"
                     /tool="antismash"
                     /translation="IAIVGMGCRWPGGVRDASGLWELLKNKRSGYREFGDHRFSRKGFH
                     HPNSEHPGTVATKGGFLLAEDPRLFDHAFFGIGSLEVETMDPSQRKLLEVVYEAFENSG
                     EPWDSFSGSTTGVFVGNFSSDHLIIQGRDTDHPRPYASVGTGTSILSNRINYIFNLRGP
                     SVTIDTACSSSMYALHLAISAIRNGDCDSAIVAASNTIIDPSTQLMMTKLGVLSPTSTS
                     HTFDSSADGYARGEGFSALYLKRTSTAVDGDYPIRALVRGSALNANGRTGGITHPGREG
                     QEAVIRKAYENAGNLPMKDTTFFECHGTGTPVGDPIEISAIGNVFGSATTPEKPLLVGS
                     IKTNIGHTEPASAIAGIMKVVLALENGFIPPSIGIKKLNPNLDLKGGRINILTENTPWP
                     DGRVRRASVNSFGYGGANGHCIIDD"
     CDS_motif       complement(6814..6855)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0005"
                     /evalue="1.10E-02"
                     /label="PKSI-KS_m6"
                     /locus_tag="EKO05_004940"
                     /protein_end="368"
                     /protein_start="354"
                     /score="8.8"
                     /tool="antismash"
                     /translation="GSIKTNIGHTEPAS"
     CDS_motif       complement(6868..6900)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0004"
                     /evalue="4.20E+01"
                     /label="PKSI-ER_m6"
                     /locus_tag="EKO05_004940"
                     /protein_end="350"
                     /protein_start="339"
                     /score="-2.2"
                     /tool="antismash"
                     /translation="NVFGSATTPEK"
     CDS_motif       complement(6916..6960)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0003"
                     /evalue="6.00E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="EKO05_004940"
                     /protein_end="334"
                     /protein_start="319"
                     /score="12.1"
                     /tool="antismash"
                     /translation="FECHGTGTPVGDPIE"
     CDS_motif       complement(7159..7197)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0002"
                     /evalue="5.30E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="EKO05_004940"
                     /protein_end="253"
                     /protein_start="240"
                     /score="13.1"
                     /tool="antismash"
                     /translation="FDSSADGYARGEG"
     CDS_motif       complement(join(7339..7378,7465..7472))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKO05_004940_0001"
                     /evalue="2.20E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="EKO05_004940"
                     /protein_end="193"
                     /protein_start="177"
                     /score="19.6"
                     /tool="antismash"
                     /translation="GPSVTIDTACSSSMYA"
     gene            9360..10849
                     /locus_tag="EKO05_004941"
     mRNA            join(9360..9886,9949..10130,10185..10294,10373..10849)
                     /locus_tag="EKO05_004941"
                     /product="hypothetical protein"
     CDS             join(9360..9886,9949..10130,10185..10294,10373..10849)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 250.6; E-value:
                     4.1e-76)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="EKO05_004941"
                     /product="hypothetical protein"
                     /protein_id="KAF9708864.1"
                     /transl_table=11
                     /translation="MALKSTNGTHAGPTASATSLASLAANISEKAASLSTYLESQGHAQ
                     PSFLPGCADPPETEGYLTLHTSLTSSLEDLQRLVDGPRRSLRPFIMIGNDLAALQVAFD
                     FGFFQLVPPEGSMDVETLAHKVGIDADRTARVLRMLATHRIFVEPKPGFFAHTAASAVF
                     HDDEELRCAGHYMLDECFKAATACSDCIKASPDDSDSTHSPFNTYFGVPMFSYYEQNPQ
                     FAARFAKAMAGVTRVDRQIAELRDCFPWGDINGTVVDVGGGSGHISMALARNFPKLDFI
                     VQDDSEKMLAQGRARNLSDIEGRISFMKHSFFHPQPIGGAGAFFIRQCTHNWCDRDVVK
                     ILKSLVPGLENSAPGTPLLINDTVLPVPGSKPLHEERALRQMDMLMFVVLGAKQRTAKE
                     FEALLKEADARYEIRRVHADGSMGLVEVHLKI"
     gene            complement(23937..25014)
                     /locus_tag="EKO05_004942"
     mRNA            complement(join(23937..24054,24110..24564,24616..25014))
                     /locus_tag="EKO05_004942"
                     /product="hypothetical protein"
     CDS             complement(join(23937..24054,24110..24564,24616..25014))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     94.9; E-value: 9.2e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="EKO05_004942"
                     /product="hypothetical protein"
                     /protein_id="KAF9708865.1"
                     /transl_table=11
                     /translation="MGGMLGFFLRQLTFTPKPLPQDVRLDGKTAIVTGANVGLGLEASK
                     EMASHGLARVILGVRTVSKGEAAKQEILKQSPDCDVQVWPVDHESFESMVAFGERAQSL
                     DRLDIVILCAGVKKLVFSLSKTGHEQNVQVNHLGTSLLSLLLLKPLKDTAAKTGSPSRL
                     TVVASEVHFWTPFDERKAPSILARLDEKDSFKGMERYNTSKLLNILWMRELSSRVTGNV
                     VINAVNPGLCASALHRSDPTPGLAYLNKIFAWTPAQGGHNLTYAATQHVDEPGAYLTEQ
                     HLAKPSPFVLSTEGKTSQQRIWDETIALFKEKVPSVDIESGL"
     gene            complement(25498..27581)
                     /locus_tag="EKO05_004943"
     mRNA            complement(join(25498..26608,26676..27283,27399..27581))
                     /locus_tag="EKO05_004943"
                     /product="hypothetical protein"
     CDS             complement(join(25498..26608,26676..27283,27399..27581))
                     /codon_start=1
                     /locus_tag="EKO05_004943"
                     /product="hypothetical protein"
                     /protein_id="KAF9708866.1"
                     /transl_table=11
                     /translation="MLQFDDPTAGMAERRASPPWEEMESGEERSESRNNQALPTLVNVY
                     GYFEESESNTWALLRQCGLHDRSKPHEYNTMMPSTLINDVQQELKDLPARGIVDFLIQY
                     FFEDINWINQIVHPPRLLAQYEDWWKMDTISRVADLEFAVLMLRICAYASHFLPSQKYT
                     VDTIKGRPLSDIRSNCDRLAGRLEGICNAAVLRGSLVRVQYMAFTAMCYECDSRIKLSW
                     ATLCCAIREAQEVGLHREPPKRGDDGMDDLERELRRRMFCNLRLAKALDRVPFLVDAYC
                     TVSLPQMHLHPTIANLQAPDLFTERVLQAQLVRFWKKLEAGNSAPGARPYDPVIAEERY
                     QRFCNEFLPELPAPFALEPNTDWDKHIPELPRQRVLFHVALFESVMHNFRQLLRLDQHH
                     LRSLPNSRMALVTQHRHTLATAAMGLFQSVTSLHAMMSFNQTKLSLVIFYHFETAVVLS
                     LCILQACDSNGMQDLEHINFFSLHSPLSPNMIDISQSQCLRAIKEARRQLEMMSLGSVM
                     AETGAHQLGILVDHVQATLARSGTQTRSMPSTETLTYNSSSSTSYGNGHAHGVSSELPF
                     TFQRQEGPTANAFRTDSNVFEGLMLWDLSTDALPLDPSFLGLEQLHEMSELQPNMGL"
     gene            complement(28338..30087)
                     /locus_tag="EKO05_004944"
     mRNA            complement(join(28338..28606,28659..29192,29240..29392,
                     29444..29775,29828..30087))
                     /locus_tag="EKO05_004944"
                     /product="hypothetical protein"
     CDS             complement(join(28338..28606,28659..29192,29240..29392,
                     29444..29775,29828..30087))
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 185.9;
                     E-value: 3.1e-56)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="EKO05_004944"
                     /product="hypothetical protein"
                     /protein_id="KAF9708867.1"
                     /transl_table=11
                     /translation="MRFIILNLLSLGITPTVVGHSGPHRQEAQNLNKFLKSNAINPAAI
                     NGETRHTGGVHLACAILEASNQTAVVFPSDGELYTQIDKAHASATAPKNPACIYTPNDV
                     KGVSLGVKVATFVQAKFAIRSGGHSPMEYFANIDGGVLISLAGIKTLEYNADAQTQRSG
                     FGNLWQDVYRHVNAQGRTVVGGRTGSVGLALTLGGGLSHLSNAYGWAAQNVLSYEMVLA
                     DGSIVIASEEENSDLYFAVKAGANNFGIVTHIVQRTYPLGKIWGGSMIFPGNASAQFMA
                     ALADYQAKGQLDKKSAILPYVGLIADAVVAQFSYLEPVERPEAFEAFYDIPVIQDLTQV
                     WDTFAAMVTAPIPYNMTRFTYATTDLLYDKEAYLEIEQICHKYIPRMRKLEGGDIMLMP
                     QPISVSMVEEARARGSDPMGVADQPQLWFVVSSGWNLAQDDAEAESIMLDALAEVEEYT
                     KSQALHLPFYFLNDAFSTQMPLQSYGAVTYSKLQAASRKYDPTRVFQELVPGGFKLV"
ORIGIN
        1 ctacgcaaga gccccatcaa caatcttgtt cgccaaaatc ttcatactcg tagcagtatc
       61 caacatttcc agcatactga catccgctcc aaatgcgacg ttgaaccagt tgcgcaactc
      121 cgctgcaatc agactgtcga caccgtaatc cgccactgtg cgcgaagcat cgacacccga
      181 agcatcaaca aacagcatct gagccaccgt cttcacaatc gcgtctgtca ccaacgccac
      241 ggtcttggat cgctcggctg ggcccgcctt gacggtctct tcaaattcac tgcgcaagct
      301 cgcaacaccg gcgttgttgc ctctttcgtt gccgccgtca ccgccgtcag ccgacgcctg
      361 gtagcgctcg gcatcgtcaa acgctcgcat gatgagcgag acacgggcat cagtgtacca
      421 gcgtggactg ttgcccgtgt tgccgttgtt ttccgccgct tcttcacgct tgcgggtcgc
      481 catagtggca gggtcgaagc aagtgaccac gttcgtcaca gagagcgggt cgtccacggc
      541 accagtatat ggttctgtgc tggcggcagg atcaagcgcc gactcattgt tcaagaaagc
      601 tggttcaaga agccggagga aattgtactc agaaatgtcc atgaccttgt tacgggccat
      661 caaagcgagt gtagtgctgt tggtactgag atggccaaca tcacggataa ggccgaacga
      721 gaccgtcgaa gctggtagac cctgttggcg tcgccatcgt gcaaagtagt cctggaagtt
      781 gtttgcagca gtataggccg actgcgtggc gagtgcgaca aaagactcga tcgtcgtggt
      841 catgaggaag aagtctagtg catgaatctt ggtggcttcg tgcagattct tagtaccctg
      901 gaccttggcc gccagcgcag atgtccattg ctcaatcgtg agtttgtcga atgataaatc
      961 ctaggatgct tgttagactt aaatcgcggc ggaaggtgga agtaaccgtc ttacctggta
     1021 agagactgca gcgtggacga tacctttgat gggtcggaca acagcagcgt cttgaacagc
     1081 ccggacaacg tctttactgt cactaacatc gcaactgacg cactccacta cagtcccaga
     1141 agcggcgagc ttgtcaatga gcatttgacc ctccgaattg atctttcgac tgcgcgacag
     1201 gacggtgaag tgtctcgctc cacgttcggc catgaagttg acgatgctcc tgcctaggcc
     1261 gcccaaccca cctgtgataa ggtaattggc attcctggcg aactgagcat gcggcgctgc
     1321 gggcaccatc ttgaccaaag cgtccggatt ctggaacgtg acgaccagct tgccgacgtg
     1381 tgtaccctta gagaaggcca ttagggcttg atctagctgt gacacgtcat acgtcgtgat
     1441 ggagctcagc ggccccattt gtccagctct gacacgtttg ttgacagttt tcataagagc
     1501 aggaccgaga gcccggtctg cgtcatccgc cacagccaag tcaaaggacg tgaaagtcgc
     1561 attgcgcttg aacagctcaa gggctaacga tgtggagttc tgcacgtcaa tacggccgac
     1621 gtcgattatt cgacccatgg gagccagcat cttgatggag tcatagagca actctccact
     1681 cgacgtgctc aggatgacat tgaaaccttt gccgtcagtg gcttccatga gcttggcaaa
     1741 gtcggctggg tcgcgagacg aaaagacgtg cgaggcgggg atgcctgcaa cgtcgatgag
     1801 ataacgacgc ttctcttgcg ttcccgctgt ggcaaaaatc tctgctccct tggcctttgc
     1861 cagttgaatg gcagaaagac caagcccacc agtggctgac tgaatgagga gcctctcctg
     1921 ttccttcagt tgggtaacac attcgaatga gtagatggct gtcatcccaa caaggggaat
     1981 cgtggccatc ttgacaaaat cttccccagg cagcatacgg taagcgaagt tggctggcgc
     2041 acgtacgtaa ttgccaaagt gacctctacc gtatccgtat acacggtcgc cgactgcaac
     2101 gtttgtcaca tttgaaccaa cctgggctac gacgccagag tactccgagg agaaggtgtt
     2161 catatcaaag cggccggcgg aagtgagaag atccttccag ttgaggccga ctgcagccac
     2221 cttcacttgg atccagtcat caggcaaaaa tttccatgtc tcttcgtacg gcttgaagta
     2281 caaggatgtc aagagaccag gcgtctcaaa ggcggctcgg acgcttcctt gggaatccag
     2341 aggcagcatc tcagcgcggc tgggtcgacc ctcggatagc tcgagtttat cttgtagtgc
     2401 gacatcggga accaatctgc tgacccagag acactcctct tgccatacaa actcgtagtc
     2461 tcgactctcg ccggcgatgc gatcggacag ggcaagctcc tggtcgagaa tggtacgggt
     2521 cagccgtatc tcttggaagt cgctgtcggg actaacgtca attgatagga attgcgaagt
     2581 agggttttcg gtcccaagcg tgcgtaggag acccgtagtg atcgaagcgt cgggatcatg
     2641 gccgtggacg atgccaccaa aagttaccca aaccaagttt gcggacttgc ggattaacgc
     2701 tttgaaagac ttgagatgag tctcgcttgc attgacgagc agacttttgc tgtcggcaaa
     2761 ggcaacggtg cgtgagttgt cgggcagatg agtctcaacg tcccctatgg agatgacctt
     2821 aaactcagtc ccacgctcgg tgagctcatg ttcgattcga cttagtaatt cgggtttgtt
     2881 gtcaccatga acaagatgta ctgttccgtt cggaacctgg ccaaccttcg caggctcctc
     2941 gactgcgcta gatacaattg tgcgagcagt ggtgtatgga gaagggtaat catccaagac
     3001 gagctcagcg ccggcgaagc cagtctggtt aagcgaagca ttccagccct ctaggtgcag
     3061 aaagggactt tcgacacgac catccggaat tccatcccag tagcccgaca agtgtccaag
     3121 aaccaatccg tggccgatga ccgcccgtgt gttttccaca acgacaagtc tgccgcccgg
     3181 cttgaccagc ttccggcagt tggtcaaagt ctttacgata ctcggggtgg catgcaagca
     3241 ctcgcaagcc acgaccacat cgtaaactgc ttcgtaaccg tgctcaagcg ggttctcttg
     3301 gatatccagc acggaatact tcatgtcctg gaaatcggca aacgcctcgc gagcttgcgc
     3361 caggaaacca ctcgagatgt cagtgaacgt gtagtcctgg tatcttttga tgccgtgggg
     3421 ctcaattaac gttttgagga tctttcgtgt agcaccaccg gttccggcac cgatttcgag
     3481 gatgcgcata ttgggattcg cgtatccaaa caggtcgaag aagcggacga gctgagggta
     3541 cgctcctgtc atgatgaggc cgtcttcgta catgccgtgt agaaggttgt cctggatcac
     3601 gacttcgaga cccgtcttgc gctcgctcaa gatgtcttcc atgctgttga atactttgtt
     3661 ggcgatcttg acgtccgaaa tgtgcccgac ctccgcgaac agttccttga tgagtatacc
     3721 gcgttgagaa cttgttaaac tgttagcctc ggcaacccat ttgttgtcgt ccgtcatacg
     3781 ccttcgaacc caggacagga acttgtcaat atgcgctggc gctgaagaaa attggccctg
     3841 gcccgcataa cgctcatgta tctcagcaac atagagcgtc ccaagccgtt ccagtttgtc
     3901 aaacaggtac gctttctcga cattctccgt aggaggggga aatcgtcgct gaacttgctc
     3961 attgtccatg gcacgaatat cgggtttcca cgacaaacgt aggaaggggc tggagaacgc
     4021 ctctttgtca acgcccgtag aaggcaagac ttctgtgtag gtgacgcagc gaaggttgcc
     4081 cacgtctaac gctacctgtt ccgatttgtc cagcacttgc agtttcgcat gagcactacg
     4141 caggcccttc atcgatccaa gagcgattgc tacggccgag tcctgtgaaa ctccattgcg
     4201 gacatatagc tggtctatat gaaccggcac aaaggcattg cgaactcggt cgatctggcc
     4261 accatgactg gcaacaagtg acagttggaa cacagcatcc agagatgcag ggtgaagcgg
     4321 gtaattcgac tctcctccct cgacggtatc acgtgtagtg tgtagggcca actgagcaac
     4381 agccaagccc ttggacggat cagctcgaat gttggacaag ggctgaaagg tagggccgta
     4441 gcccagccca atctcggcaa atttcttgta ccaggctttc gtgtccaggg ttcgagcgtc
     4501 catctctgta gacatcttct cattggcaac ggatgttccg gcaatcaccc tgacccgacc
     4561 agaacaatgt tctgtccatg tgccggcctc acgtgcgacg gagctaatgg aaaacatggc
     4621 ccatgtgggt gctttgggat ttacagcgtc ggcaagctct aggctcgtga taatctcgag
     4681 accaaagtca tcatcaggaa gcctcatggc cgaagaaaag gtgacattgc ggagcttgta
     4741 tccagtaatg tcaagtggct cactctgttc attgtatatg cgcgaagctg cctcgattac
     4801 tgtcgcgatg taacccgcag cggggaacac aggatatggg aggagcttgt ggtcgttgag
     4861 ccaagggaga tcttttaatc gaaggatatt tcgccactgt ggccgcaact tggcatttcc
     4921 tggaagcttt gatcccagca ggtcgtgccg aacaatatct cgcccacgga actccttgct
     4981 gaagcggctt tcgtggtata tgaccggtcc atatgcgtac tgataaggcg ggaggttggt
     5041 tgcagtagtg ccatggacaa gcttcaactg gttggcgcta atcacatcaa cggcgttcac
     5101 ggcagtgagg tccacttcgg cattcagact gaatagacta ccggcgagtt gaagcaagct
     5161 gatccctcca tttgtaccgc ggttcaaggt cgagaaatac ggcagtgact tgtcgacgct
     5221 tctcgagatc tggccaacgg gacctttgag agcagggtgt ggcccgatct cgacgagcac
     5281 gtcaagcgga tctggaagat tcaacatatt ggccaaggcc tccgagaagc gtactgggga
     5341 ttccaggttg gcgcgccagt aacttggaga gacgggaaga ttctcggtac ttttgcttgg
     5401 atagacagat gacatccatg gccgtgtggc atacaattgt gacggttcag cctggcccag
     5461 agacttgacg tagtcgaggc cttcggagag ggtgctgtta tagaattcac ccagagcaag
     5521 catatggtgg gaatgatatg cgttaccccc agtcttgagc tctcggctga acactttgtc
     5581 ctcattgagc ttagcggcaa cgtccttgat ggtagactca tcaccagaga gcgttacgct
     5641 gtcgggcgag ttgacagcag cgattctgac gctggactcc aagccagaga tgtatgcctc
     5701 agctttgtct aggcccagtc cgaccgccaa cataagacct ttgctcttgt tcttggatac
     5761 ggcttggcct cgaaagtagg cagcagcaat cgcctgtgca gcagtgatcc ggccagctgc
     5821 gtacgttgcc gctatctctc ctgacgaatg tccagctact gcagaaggcc tgacgttcca
     5881 tgtatagagc aggtcgacaa ggccgatttg gacagcggta cacacggtct gggagacctc
     5941 cggcttgtga atatcattgg gatcgcaatt ccctgccaga acgtcttcga tcttccaagg
     6001 cgacggtgtt ggcaggctgg cgagaataga gtcgagatac tcgatggagg ttcggaagac
     6061 ggcgtattcg aacaggtctg cgcccatcgc gtgccactgg gctccctgtc cagtgaaaac
     6121 aaaaccaagc cttgcagttt gggtgccgct ggcgagtacc ttctccttga ctgcaaagtc
     6181 attagcgggg ctttcactgt cgacgatgcg gaaagttctc tgcatgaatc tcgagcgttt
     6241 tgccgccagg gtgtaggcaa catccgccag attctccctc tcgatagcct cggatatcgc
     6301 ggtaatgttg aggtcgaggg aggcttcatt gtgtgcggag aacgggataa gcacacgtcg
     6361 tcgaggtttg gcattgatgt ccttgaccag ggtgggttta tatgagaagg gatagtggac
     6421 cttgtccgct ttttcaacca aatgcgatgc agaatttcca ttcattccgt tttgatgatg
     6481 tccgttgtga ccattggacg catgggtgcc attggtgtgg ccgttggtgt ggccgttgtt
     6541 gtgaccaatg gacgtatttg ctgttctttt cttgtaatca ggcaacacat tcctgacatc
     6601 gtcaatgata caatgtccgt tcgcaccgcc ataaccgaaa gagttgacgc tggctcggcg
     6661 gactctgccg tcgggccaag gggtgttttc cgtcaagatg ttgatacggc cacccttcaa
     6721 gtcaagattt ggattaagct tcttgatgcc gatactaggg ggaatgaacc cattctcaag
     6781 cgccagcacc accttcatga tgcctgcaat tgcgctagca ggctccgtgt gcccgatgtt
     6841 ggtcttgatg gagcccacaa gaagcggctt ctctggcgtg gtcgccgaac cgaagacatt
     6901 gccgatggct gagatttcaa tcgggtcacc gacgggcgtg cctgtgccat ggcactcaaa
     6961 gaacgtggta tccttcattg gaagattgcc ggcgttttcg taagccttgc ggatgacagc
     7021 ttcctggccc tccctgccgg gatgggtaat gccaccggtg cgaccgttgg cattgagcgc
     7081 agaacccctg acaagagcac gtatggggta gtcgccgtca acagcggttg acgtcctctt
     7141 caggtacagc gcagagaagc cctcgccgcg cgcgtaaccg tccgccgagg aatcaaaagt
     7201 gtgactcgtc gaagtgggcg aaagaacacc gagtttcgtc atcataagtt gtgtactggg
     7261 atcgatgatc gtattggagg cagccacaat tgcggagtcg caatcgccat tcctaatcgc
     7321 actaatggcc aagtgtaatg cgtacattga ggaagagcaa gctgtgtcga tggtgacact
     7381 gtgtttaatc agcactgaac cgccttgttg agaagcagtt gctcagagct gtggttgaac
     7441 ttagtgaaag taatgaatac tcacctgggt cctcgcagat tgaatatgta attgatgcgg
     7501 ttgctgagaa tgcttgtgcc ggtaccaaca ctcgcgtacg gcctgggatg atccgtatct
     7561 ctgccttgaa ttatgagatg atcagagctg aagttgccga caaaaacgcc agtggtcgat
     7621 cccgagaaag aatcccatgg ctctcccgag ttttcgaaag cttcgtagac cacttcaagc
     7681 agctttctct gcgacgggtc catcgtctcc acctcgagcg aaccaatacc aaagaaggca
     7741 tggtcgaaga gccggggatc ttcagcaagc aagaagcctc ctttggtggc aacagtgcct
     7801 gggtgctcag aattgggatg gtggaatccc ttgcgagaga agcggtggtc accgaattct
     7861 ctgtatcccg aacgcttgtt ctttagaagc tcccacagac cggacgcgtc tcgaacgccc
     7921 ccaggccatc tacagcctgc aaaaaatggt tagcatgtga agttgttgta tagcatagtt
     7981 gggcctaccc atgccaacaa tggcgattgg ctctgggtct gcagaagtgc cattggttcc
     8041 gtattgggaa ctcatcgtca aagtaatatc tggcgatgaa gcgtcagatc aggagagtgt
     8101 tgatcagttc ttgacttcct cgcctatgtg aatagcaaag tctaacgaga aaacgagagc
     8161 gtgtaacgag ctttaatgtt tcactcttca ggtgtcttat aggcaaatta caccctcgca
     8221 tcggacggca ccctaggtta tggatttgct ccacagtatc caacctcgtt ttgatactgc
     8281 tgagatatcc cgcatcatgc agataccggt aagctcaacc atgcagtgca gaatcttggg
     8341 ccgacaatta aatgcccgta taccaagaat cgaacactgg cataaactac tctgacactg
     8401 ataagcagca acacgacgtt actggctatg ttttggatgg cgcatgtatt ctttgaggat
     8461 gggcgaccaa gaggatacac tcaaaccgat ggctgagggt caatctacgg cgtcagctcg
     8521 tctaggtcct aaatgcggct ttaccagtac gggtttaagg cttcgggtct tttgggtctt
     8581 cgctttattc ttgatagacg ttcgtctagt agccttgtaa gtgatatagc atgtcacgtg
     8641 atatcttgtc gcaggcgtcc acggtctctt ctccaacctg gtttgtaggt ggactgcgcc
     8701 acacgaagcc ttttgagctt acgtttaaga gccgtcaagt catcatgcat tgaaaagaaa
     8761 gatgctccaa tgaaatgaca gcatgtcatg tgaacatcga ggcttcagga gctcaccgcc
     8821 tgtcagtcag acccaccacc ccgccagatc cttctgtgaa cgtccacaga ttagaccgtt
     8881 ccgcccacgc cccgacgggc atatgggtaa ggcagacggt tcgcttgaag atcgatgatt
     8941 cgggtcgaga taggtattgg gcctatcaaa aggtagtaaa gtagccacac ttatgcagtg
     9001 agaattgctg acagtgcgcc gaggaccgaa aaacatcggc ctaaaaaggc gtgggctctc
     9061 ggtcgaagaa ttacacgagc tgtcggccgt ttcccaagac acatggtatc atgcaccggc
     9121 cgtttcgtcg cttttgcggt cttcgtttgg acgaaagagc gtgcatcgga ggtacgagat
     9181 gtcttacagc attagttacc tgggttgcat aatgctttga tcgaaatcga cgtctagctg
     9241 agacggaggt tgagagggtt caagacataa gcaccttttc ttcgtgaatt cgaaaccata
     9301 aaccttctcc ctttgcgatc aaaacgtgcc gcaaccagag attcatccta ccccccacca
     9361 tggcgctaaa atccacaaac ggtacacatg ctggtcccac cgcctctgcg accagcttgg
     9421 cctctttggc agccaatatc tccgaaaagg cggcaagcct cagcacatat ctggagtccc
     9481 agggccatgc acagcccagc ttcctcccgg gatgcgcgga ccctcctgag actgaagggt
     9541 acctcactct tcacacgagc ctcacctctt ctctagagga tcttcagcgc ctcgttgatg
     9601 gcccaaggcg cagcctgcgc ccattcatca tgattggtaa cgacttggcg gcgctgcaag
     9661 tagccttcga ttttggcttt ttccagctgg ttccgcctga agggtccatg gatgtcgaaa
     9721 cacttgcaca caaagtagga attgacgccg atcgaacggc gcgtgtgctg cgtatgttgg
     9781 caacgcatcg tatcttcgtg gagcccaaac ctggattttt tgcacatacg gcggcttcgg
     9841 cggtgttcca tgatgacgag gagctcagat gtgccggaca ctacatgtat gtttgtgtca
     9901 catgcatgca acgctgcatt gatactggat gtcctaacca cattctaggc tcgatgaatg
     9961 cttcaaggct gccacggctt gttcagattg catcaaagca tcgcccgacg actccgatag
    10021 cacacactct cccttcaaca cctacttcgg tgtgccaatg ttctcgtact atgagcaaaa
    10081 cccccaattt gcggcgcgtt tcgcaaaggc aatggccggg gttactcgag gtatgtagaa
    10141 tccgtgaacc cacactagta ggccaatccc taagctgttg acagtggatc gtcaaatcgc
    10201 cgaactgaga gactgttttc cttggggcga catcaacggc accgtagttg acgttggagg
    10261 cggcagtggc cacatctcca tggctttggc tcgcgtaagc ttttccttcc tcgcatctgc
    10321 aatgatgctt gatcacttca tttcttgact gacatctcaa ttccgcaccc agaatttccc
    10381 taaacttgac ttcatcgtcc aagatgactc cgaaaagatg ctcgcgcagg gtcgggcgcg
    10441 caacttgagc gacatcgagg gccgcatctc cttcatgaag cacagcttct tccacccaca
    10501 gcctattggc ggcgccggcg cgttcttcat ccgccagtgc acgcacaact ggtgcgaccg
    10561 cgacgtggtc aagattctca agtctctcgt gccggggcta gagaattctg cacctgggac
    10621 gccactgctt atcaacgaca ctgtgctccc ggtgccgggg tcaaagccct tgcatgagga
    10681 gcgcgctctc aggcagatgg acatgctcat gtttgtagtt ctgggtgcta agcagcgaac
    10741 agcaaaggag ttcgaggcgt tgttgaagga agccgatgcg aggtatgaga ttcgtcgtgt
    10801 tcatgctgat ggcagcatgg gtctagtcga ggttcatctg aagatttgat gacgtcactg
    10861 tgacgtgctc aggccggcga aatgggctgc aaacctgaca gtcccgatga acatgaaatg
    10921 gaacctttat gactcctgac ctccaattat gtgcctaagt gcctgtctac ttcacacaat
    10981 ttatccgatt tctgtagagt gtggtaggtg cgttttagtc aattttagcg tagtgagcac
    11041 ctactggtgc ctgctagggt gacgcagcag gagttgtaag ggcacgttaa taatcaggta
    11101 ggagtgtcta ctttaattaa gcctgtaatt tacatagtac tgtgtagtat tttaagacta
    11161 tctgtaagga gttagtgctc taccctaccc tttaaatctc tacaatccct actaattaac
    11221 ttaaaacatt aatagttaat ccttagctaa ctcttactag ttggaaattt aagcaagcta
    11281 tcctatatat cttgccttaa ctaagtctta ttaagagcgt taaattatag ctaagacaga
    11341 tatttagcta acgtactcca caagcaagcc gcttacctaa gcaaaccgct cacttttgct
    11401 aagaccacac caaacttcat actacctaca atgctgcaac gcaacaacgt aaaaaagccc
    11461 ttaaatgaag cagatataca gcttgcccta caggctattt aataagacac aacactttct
    11521 tagcaacacg ctgcagtaat ctacaacatg ccttaaagaa cacttagtaa ttaacttgct
    11581 agagcctctt tataacgcaa ttgcaagcct aaattaataa agctaacaag cactaaagag
    11641 gaggtaattg tccagtatgt attaaagcta gacaagtaag gatacttgcc ctagcttact
    11701 aatgtagagg atatggccaa ttctctgctt acagagcgcc actagacctg tgttagtaag
    11761 aactaggctg ctaactttgt taaacgttag ctagagctta aaattaagtt taattgtaag
    11821 tataactaca agagagccct gtgtaaggat cctaaggtga ttagagactg gttctagtta
    11881 gtagagaata ctaaagctga gtatagtatc ctagataaag acacctacaa ctttaacaag
    11941 tctggcttta taataggtgt tatatctaca ggagctgttg ttataggctc taagcgttaa
    12001 gggagaccaa aggcagtgca gcagggcaac tgagagtgga ccagcattat ctaaggcatc
    12061 tgcgcgaagg gctggtctat cccacccttt attatcctct ctagcaagca ctacctctta
    12121 gcctggtaca aggagcccag tatacctaac aactaggtta ttagtgtctc taacaacagc
    12181 tagactaaca acaagcttag agttaagtgg ttaaagcact ttaataagca cacaaaggcg
    12241 cgcactatta gcagctatta gctgcttatt ctggacagct ataagagcca caacttagtt
    12301 aaattctact agtactataa ggagtataag attgttactc tgtgtatgcc tctacactcg
    12361 ttacacctac tgcagccact taacgtaggc tgttttgccc caataaagaa agcctatggc
    12421 cgctaagcca agtagctaat acgcagcaag atcacgcgta ttactaaact taagttctta
    12481 ctatgcttta aagcggcttt tgacgcctta attactgaga gcaacatcta gggaggattt
    12541 agaggtgctg gcctagtcct acttaaccta gaagctgtaa tcttaaagct tgaagtgcag
    12601 ttgtgtaccc taccactacc ccttatagat aagagtacct gggagtctaa aacactaagc
    12661 aacaccctag agtttaggtc ttaatcaaag ctgatttaag agaggattga gagacacgcg
    12721 aatagctcac caactttaat agttaacgct cttaattagc tcactaaagg cgcagagctg
    12781 atggcgtatt tactagtttt agtgcgcaac taggttacta acctttagat agctaacaag
    12841 gctgctacac aacgtaaatt acacaaaaga aagcaattat agtaagaagg gactttaacc
    12901 tttgtagagg gagtgcggct gactactttt aaggagttta aggcctgtag taataggaag
    12961 aaggcaaaga agaggttgcg tgttaatagg agcacttagt ctttaaggcg ctgtagtaca
    13021 tgtagcaaga caggacataa cgcgcgaaca tgtagtaaag atgcgcagag tactgtagat
    13081 tagtgcaata tactatgtag tataatatat tgttattata tactataatg ttgtaaagta
    13141 gttgtagtgt tggtgtggtc ttggcaaaag tgagcggttt gcttaggtga gcggctcgct
    13201 tgtggagtac gttacttcta gttatgcaag aacaattaga caacttaatt aatattaggt
    13261 acctccctaa cataatctta gctttataga ctaagactat aattatctta ttatctatac
    13321 cttatatagt taataatata ggttagtaac actatttatt agtatctgca gctagaatac
    13381 caccgtacta gtgttagata atatgcttaa tgtacaaaga tgataataaa ggtgattaat
    13441 taataattat ctgtcttaat ggctcatttt atgtgtgtgt gctgctagcc cctaagttaa
    13501 ccaaggttaa ccctaaaacc ccaacttggc ttagtaaggt tagttatcta acacaccccc
    13561 ttagctttaa ggccctttta aagctagaca caattagctc ttattatact tttaggttag
    13621 caagctttta gttaagtaat tctatctagg tgttagctag ctttctttgt ttagtatgtt
    13681 tctttagttc tagctacctt agtgttaggc gctaggccta gggttacctc tgctagtctt
    13741 agcgagctac tatagggcta gccagtccag actatataaa ggtgttagag gttattgcta
    13801 atactctagt aattagtctt gttactacat actacgtacc ttaatacacc tactatcctc
    13861 tttaaaccta tcctccctta taattacttt gtatattctt tatattctaa ttactcttat
    13921 attataatta aagatagacc taagctacta taagtcttaa actaaattat ctaggcttac
    13981 tgtctttaga gagggactaa gacaacctac ctgtaggaga gctagtagag cgtaaggtaa
    14041 cacctccctc tacagataag gagatacctt aatagacact aagtgtctat agtgccttaa
    14101 gaggatctgt aggtcctcta ggcagtacac cttaccctag aatttgcatc tgtagggcag
    14161 cttcagctag agaaggccag aatagcctag aagtaggtaa ttaataacag gagttagaaa
    14221 acttacgcaa atagttgtaa gagacagaag actataagga actttcctct ctttataaac
    14281 ttagacgtaa atacaacaaa ggagatctag taataatcct atccttctaa aaagtactag
    14341 aaggggtaga gaaactacaa tcttccttat ctataaacct tctacaacct aaacccctat
    14401 agaagtatat aaagcacaac tgcgctaaat acaactatta gaagagagat agggatactt
    14461 cttctaattc ctagttaatt tccttataga ggaataaaag attaacttta gcgtaaggta
    14521 cctcttagag aacctaaaga cgttatagca ggcctactgc ataactaact actataatca
    14581 gctaacctag gaactaacgt agtaagagct aaaaagaaat atattagata ctctaggaac
    14641 actagctaaa cacaagtaag cagcgtataa atccttaaag taatataagc agtagaaatc
    14701 ttagtcccct atagatctat tagattttat acatctacta tagaaggaac taggcaactt
    14761 acatacgcta gagctttaag tcctagaata tattactgca ctgctcccta gcatataaaa
    14821 ggacttgttc cttatcccct acaattaaag ggacataatc ctaaaggtag aggaacaagc
    14881 taacattatt aactagagac taggttagca tagctaacag ctacctaaga agactctagc
    14941 taagggcaag acaactaaca aaggactaca gaagcgctag tttagtaact ctaggttaga
    15001 aaggaacata aaaaccctaa gtaagttgtt taagtctaag aagttctgta aggagctagt
    15061 aaagggtaaa aagggctaag ataggctata taaggcctaa aacgcgtgcc ttaagtatag
    15121 agaaactagt tactactgcc ctaactacct ggagctaaag ttaaactaga aagaccctac
    15181 tctagataag ttaggaaaag ataagggacc taagagctaa tctcctctct tatagcctat
    15241 attaaattgt ctaagaagaa gaaggaaaat atctctcttt ataaggcagt gtacctagaa
    15301 tatatacgcc tgcttacagt taaaacatct ataggcaacg cagagaatat agaagcctta
    15361 atagatagag ggttacaact aaacttaatt ttagttcttc tagcaaagga gcaggatcta
    15421 gaggtcacac tattaaataa aatagtggct aaaggtgtag gcagagcaga attgcctatc
    15481 tacagagtaa ctacagcaga agtatctatt gttaactcct gtggaagata ggaggtctaa
    15541 cagatacctt ttgtagttac agacctacaa aggtacaaga tataccttag attaccctag
    15601 attaactaga taaaccctaa gctaagctat ttaagctagc gtatgctctt ctaagggaag
    15661 aagtatagaa actctcataa actagagaaa atagcgttag aagatgctaa agagtttaaa
    15721 cgcactataa gaagtccttt agcagacgtt tatatatata tagtaaactt agtaggtata
    15781 tataacctaa tatctgctaa aaagggccta attctagaag tgtattgcaa atatgcgcac
    15841 ttaggattag aggatgatgc ttaggtccta ctagagcata gagagcacaa cctagcaatt
    15901 aatattgtag aaggagctac ttccccctac taactgttat acagactatc tgtaatagaa
    15961 ttagagatac ttagaaagta tctagcagaa tatctataac atggctagat ataacactta
    16021 aggtcgctag caggggcgcc tattctcttt ttaaagaaga aagacagtaa cctataactg
    16081 tgtgtagact atagaggtct aaacaagata acagttaaaa actactatct attgccacta
    16141 attatagagt tactagaaca actagcgcaa gctaagttct atattaaact agatgtacgt
    16201 aaggcatatt actatatcta aattaaggaa ggggataagt agaagactgc gttttaaact
    16261 aggtatagac attttaagta catagtaata ctatttagac ttataaatgc tcctacctaa
    16321 ttttaggcct atataaacaa ggcactaata ggattagtta atataactta tattgtgtat
    16381 ctagacaaca tattagtata ctctaagata gaggaagacc acattagaca cgttaaggag
    16441 gtcttagaga ggctttacaa agcaaacctc tatatacgct tagataagtg taaatagtac
    16501 tgttaacgta tagagtacct taggtatata gtcttgccta aagaggtaag cattaaccta
    16561 gacagggtta aaccaatcta agaatagcta attccgcgca tagtttgcaa tatctaagta
    16621 tttataggct ttataaacta ctattagaga tttattatag ggttttctga attagccttg
    16681 ctattaacct aattaaccta gaaagggcta aatttggcca aatctagtta agtaataagg
    16741 aagaaggaga gttagcctct taagctaagt aaagaatccc tataagcttt ctagaatata
    16801 aaggatttat ttattaatgt acctatctta gtttattttg tacctaggag acagactagg
    16861 attaaagtag atgcctctag aggcgctatc tcaggattcc ttagttaact agtccctaga
    16921 gaggggaagc cagcctaata gaggcctgta gacttctatt tgaagaagtt aatctaagta
    16981 gagtacaact ataatactta taactagaaa cttcttataa ttatctagag cttacagtat
    17041 tagcaaagat acttagacag taccttcttt aagatcttaa cagattaata aaacctaaag
    17101 tagtttatag agacaaaggt tcttagctat tagcaagtaa gggcatactt agtgttatct
    17161 aagtttaact ttgtaattac ttattaccta gggtctataa accctgcaga tagaccctta
    17221 cagcatccta attatataag agaggcttaa gaccccttat aaaagtacaa tagggctttt
    17281 atacaactgc tttaggagat cctaactaga aggaacccta atactctcct agtagcagct
    17341 ataacccttt gtttgtctgt aaaaggaaga aaggatataa gggatcttaa aagagaagaa
    17401 ttaagagaga acagttagat agagctaaca acggacttag acaacacaga caaactctct
    17461 agtactaaaa aagagttaag taacgttaaa ataggacaaa ataacctaga aaaagacaat
    17521 atagctaagg agaggcgtat cttacttata aggctaaaag ataaagtgta agttattaaa
    17581 gagtattata ataacctaat attaggacac tttagagcat aaaggacctt agagacgatt
    17641 tagcgcagat acacctagag gggcattaat aaggatatat ctaactactg ccacaactgc
    17701 ttagtatgta ggagattaac tactgcctaa cacaaactat acaggttatt ataaccttta
    17761 ctagtgctaa gctaactata ggaggacgta ataatagatt ttattacaga actaccccct
    17821 agcaaggtag ctaggttagt gtacaactta atactagtag tagtatgtaa attaactaaa
    17881 atatcacatt atataccagc cagggctaat taggatagaa aagacctagc acacacctag
    17941 attagagaaa ttatctgctt acacagcgcg ccagcacaaa ttatcttaga ttaggggttg
    18001 ctaataaact taaagacgta ggaaaccttt aaccactatt taaacttaag acaagtctta
    18061 acgttggcct attatcccta gacagatagc taaacagaaa ggcaaaatca gactcttaaa
    18121 cagtacttac gttgctatta tactctagaa taagacaatt aggccctata gattttaatt
    18181 gcagaattta tgtataataa tagcatttac gcatctataa acataacacc tttctaagcc
    18241 tgttacagta tagatctaag aagtatagat tagcctactt tagtattaaa aggccgagaa
    18301 tctcccctta caaaggaatt agctactaga gttattgcct tataggctac ttgcaaagta
    18361 aatatagaaa agttaaataa gtattaaaag aaacacttag ataagaaaca actactagca
    18421 ccctttaaag taggcaacaa agtactagtt tctagtaaga acattaggac agtacgccta
    18481 aaaaagaagc tagactagaa atacctagga cctaggacta ttacagccta gattggccct
    18541 agtgcatata gagtagacct gctaggaata aaagggatct atctagtatt ctatgcgtta
    18601 ctgctagacc tatacatact aagaagttaa ctcctaatta tatagaaata aatacaagaa
    18661 cctatagtta aaggggaaga gaaggtatag gatgtagaaa aagtccttaa cagaaggtaa
    18721 ctagacaata gacagtagga ataccttatt aagtaggaca gattccctaa attagaaaac
    18781 tcctaggaaa ttagcacaaa tctttctaaa gaagtgctaa aataatacta gaaaactata
    18841 aagtaactgc ttagaccgcg taataagacg ttaaggttaa agtttaaaaa agggggggac
    18901 taaaaaggct aaataccttt acttaattat aatttttccc tataggggtt ttttaactaa
    18961 taagtgttta atagtttacg ctaagggaaa acataaccct accttaccct aagaaataca
    19021 gactagctaa agcaggcatc ttttagccta ttatagctat ttctaatata aggagataaa
    19081 gaaagttata cgctacgtta tatagttaca attgtaagca aatataggag aattggtgta
    19141 gaagaacacc ttcctagtat tatttagact atctaagagt gcaatgcacc taattgccat
    19201 attggcctga aaccatctac tgactacaaa cttaggtatt attaatctaa accttccatt
    19261 atagggaaca tctattaacc acaacctcta ctacaggcat gagtggcagc cttgcgacca
    19321 ctacgaggct tcttagcagc atcagcggca gcctgctcgg cggcctcttg ctcctcccgc
    19381 tcctcttaga gttgactaag tgtctttcta gtgcctgtaa tctggtactt taactataaa
    19441 agaagttaga tattgttaaa acaggttaaa acatgctata ataccttctt gcggggggtg
    19501 atgggcgcat ctggatcaga cttgccaccg ctctcctcta acatcttctt tcgctttatc
    19561 tcagccttaa cagcgctagc cttagattaa tcttacttct taacgtagat gctggacaag
    19621 gttaacttac gtgcgcaagt gttgctatta tagagtgtaa gcagctcttt ctgcagcaaa
    19681 tagttcctat aaaggttaga ttatgctaac gtactctacg ggtgagcgga tcaaacgggt
    19741 gagcggatca ctctgctaag accacaccaa acctccacct taccacgcaa tgcctcaaca
    19801 acaacattaa tctacgccct taagagaagc tgcgatacag cttgcgctcc aggtaattaa
    19861 ataagacgca atacttaccc tataacgcgc tgcagctata tataacgcgc cttacagcac
    19921 actacacgct taatacacag gacaacctac acaagctaat tgtacgctag tttaacagat
    19981 tatagaccag actaaggagg acgtaattgc taagtatatc cttaagctag atgtacaagg
    20041 atttgcccct tagctagctg ctatagctaa tatagctaat tctttgcgta ctaagcgcaa
    20101 tataggccat gttagcataa actagcctaa cacgtttgtt aagcgccgcc ctaaccttaa
    20161 agtaaggttt aatcgcaagt acaactacaa gagagccctc tgtaaggatc tagagattat
    20221 taggggctag tttaggctta tagcgaatgt caaagctaag tatagcatct aggacaataa
    20281 cacgtacaac tttaataaga caggctttat aataggctag atattaacag gagcagttgt
    20341 tataggctta gagcgttaag gacagctaaa ggcagtgcag tagggcaatt aagagtagac
    20401 aacggttata tagggcatta atggcatagg gtaggctatt ctacccttta ttatctttaa
    20461 aggccgcaac cacctctctg cctagtacaa agaggacaat ctgccctata actgggttat
    20521 tagagtctct gagaacagat ggactactaa caagcttggt ctagactggt taaagcactt
    20581 taatgcctat acaaagacac gcacctaaga agtacactag ctgctcctta ttaacagcca
    20641 caagagctat aactccctta acttttaata atactataag gaagcaaaga ttgttatact
    20701 atgtatgcct ctatacttat cttacctctt ataactacta gatataggtt gttttacccc
    20761 tctaaagaag gcatataggc gctaagctaa gaatcttata cacaactata ttacttatat
    20821 tactaaaact aagttcctac tatgctttat agacgcctat aaggagacat ttacttctag
    20881 caatatctaa ggaggcttct aaggcgctag aatagtcccc cttaacccag aacgggtcat
    20941 aataggtctt aatgtccgcc tacgtaccct accgctacct actgtagaag ataagccctg
    21001 gcagtcctaa accccaagca ctaccctgca attagggtcg caattaacac tggtttaaga
    21061 gaggattcaa aggcatgcaa gcagctcacc aactttaata gttaaggcct ttaaaaagct
    21121 tgctaaaggc gcagctatag tagcgcataa gctagtgtta gcttaaaggg agattactag
    21181 gctttaagca gcaaataagg ctgctatgcg acgtaaatcg cataaaagaa agcaattaca
    21241 gcaggaggaa gttctaacag ctaaggaagg cctttaatta actactctaa ctaagtttag
    21301 ggcgcgtagt aatagtaaga aggcaaagaa gcaagtgcgc gctaaaggag gggaagtaac
    21361 ctaaagacgc tgtacaaagt gctacaatat tagacataac ttacgtacat gtaagaaggc
    21421 tgtagaagat atttctaaat aatattatgt actgcactac tgtatacaag gccaaagtgg
    21481 gctaatgcga gctataatag ggtagaaatt tagtgtagtc ttagcagagt gatccgctta
    21541 cctgtttgat ccgcttacct gtggagtacg ttaatagcta gtgtcttagt acaagcttgt
    21601 attgtagatc taacctaatc ttaaaggtta gcattttatt ctatcctaaa ttgtactatc
    21661 ttagcaattc tattacgtag ggtaaactat tctagtgctt tatctttata gacgtagtag
    21721 caatcttcta gtctatagcg ttgtctataa gtagggcatt ttgctcctct agctgctact
    21781 gtatcccctc ttagggactg cttagatata gttatttaac taaagttctg tttttaacaa
    21841 ggtcttccct aactccccta tgtagtagga gtagataatg catctttaat aacataagag
    21901 gcgtccctgt tagtgtctag ggtagattta ctacgagtag taagagttaa gttattccct
    21961 gcagtaaagg cgccccttta ctatctcccc ttagggtagt acttacttat atgctcttag
    22021 aagcgtttta ttatttcttt ataagttata ttttattctt atctattata gttctagaat
    22081 attattgcct aggttagtac tatctttatt actaaatcta agaagtctta gacagtgtct
    22141 tatatattgt atatttcagt aataccctct attttagtgt tagttgcagc ataattatac
    22201 ttaaggagct aggtatccta gctcctaggt tatcttatta gtttaagggc tgctaggtat
    22261 tagtagcgtg tgcgtaatta ttcttcttta gtattaatac taactatata tttaaggcta
    22321 ataagctatg tttaaattaa tttacctagt tagcagtagt tctttataag gtagggtaat
    22381 acaaagcttt acataaacat tactaccttg tctaggttag cttgttcctt atagtagtct
    22441 ctatccgcta tcttgtagga tttaaagcag ctcttctaat agttattatc ttccttctat
    22501 gcctttaggc tgttagctga tagtttagat aggattttag gaagctaagg gtttccttgt
    22561 ttattattac taagggctag cctcctctta tagttggtaa tatctagggc gttaggtact
    22621 tgtggcttag tccttagagg gatagtctaa tttaggtcta tcttctccta tacgtctaga
    22681 gaggcgcagt aggtctacgg ttaatataac taaggtgtgt aggttatata atctataaga
    22741 attattatta aattatgtat agttaatagc gacatattaa aagggtattt tagtagtgtt
    22801 agtaagactc ttaattgtta gataatatgc ttaatgtgca aagataataa taaaggtaat
    22861 taattaataa ttatctgtct taatggctta ttttatgtgt gtgtgccgct agcccctaag
    22921 ttaactaagg ttaaccctaa aaccctaact tggctcggca aggtcggtta tctaacaact
    22981 agtaactaga taatgtaacg taccccacag gcgaaagaat caacgggcga gagaatcaat
    23041 tttgctaaga attagccttt tccttaatta cttagcgaaa ctataagcaa ctaggctaga
    23101 atttaagaaa tagatatata gatactatat gctaagtgta ttaaagttgc acttatctta
    23161 cttctagatt acgtaagtta ttaagcctta aagtaggtct attctagctc tactaatacc
    23221 cctgtaacta ctatctaggc ttactaataa acttagataa acttatataa tactattaaa
    23281 tatattttct attataccta aagagcctaa ggctataact ctagtagttc tagagatata
    23341 gagttatagt agctttttaa agtagggtta ttagacagct atgtctaata tagctaatag
    23401 aattctatag atctagttaa ttactctttt tatatataaa aatactctct agcaatttta
    23461 aagaatttta tctactagat ctagagttat taagtgttag attcttggtt ttcgctagta
    23521 aaacggagtg attctctcgc ccgttgattc tttcgcctgt ggggtacgtt aagtagacag
    23581 tagacacccc tatcgaattt tacaagacac ccctcacatc gtccaattga tctgattatt
    23641 agatccaaga attggatatt tcgtgtgaag tagacagacc ctaaattcaa gaaaaccaaa
    23701 aatctgttag tatgcagctc tgttgtataa gcattagcga aatcgctccg tactgcattg
    23761 cacccttcac atccaacagc acagcaatga aaaacctgtt ctagatggca gaaatccgta
    23821 tagaaaaaag ggaattgtca tgctcaatta cctatcagtc taacacaata ctcaagcacg
    23881 ggagcaggga agccggaggc gaccaacgag caggcatacc atctgttgtc taaaagctac
    23941 aagccgctct caatgtccac gctcggaacc ttctccttga acaaggcgat agtctcgtcc
    24001 caaatcctct gttgcgacgt cttgccctcg gtcgaaagca cgaaaggaga tggcctgcat
    24061 cgtattagta tgacctctcc acaccgctac tacaatgtcg ggggcttact tggccaaatg
    24121 ctgctcggtc aggtacgcac caggctcatc gacatgctga gtcgcggcgt acgtcagatt
    24181 gtgcccaccc tgggcgggtg tccaagcaaa gatcttgttg agataggcca agcctggagt
    24241 cgggtcagaa cggtgcaagg cactggcgca aaggcctggg ttgaccgcat taatgacaac
    24301 gttgccggta accctgctgc taagctcgcg catccagagg atgttcaata gcttgctcgt
    24361 attgtagcgt tccatgccct tgaatgagtc cttctcatcc aagcgagcga gaatggaggg
    24421 agcctttcgc tcgtcgaacg gggtccagaa gtggacctct gatgcgacaa cagtgaggcg
    24481 tgaaggcgag cccgtcttcg cagccgtgtc tttgagcggc ttgagcagca acagagagag
    24541 aagagaggtc cccaggtgat taacctacag gggatcagtc agtatgacgt ggtcagacgt
    24601 atacagagca ccaacctgaa cgttctgctc gtggccagtc ttggagaggg agaagacaag
    24661 cttcttgaca ccagcgcaca agatgacaat gtcgaggcga tcgagggact gggcgcgctc
    24721 tccaaacgcc accatgctct cgaaagactc gtgatcaaca ggccagactt gcacatcgca
    24781 atccggagac tgtttgagaa tctcttgctt tgcagcctcg cctttcgaga ccgtacgcac
    24841 cccaagaatg actctggcca aaccatggct ggccatttcc ttggaagctt ctagaccaag
    24901 gccgacattg gcgccggtga cgatggcagt cttgccatca aggcgaacat cttgggggag
    24961 cggcttcggc gtgaaggtga gctggcgaag gaagaaacca agcataccac ccatgttggc
    25021 gatgaggggc agggcaatag gactagtata atgcagaaga tgggcacatg tgcttcacct
    25081 agctgtttgt ggtagatttg ggaggaggac aggaacaatc cagcaacagt agggccgaac
    25141 gagcgggaag ctgcgagaag ataagtgaag gataaattgg cgcgcccagc tgacgttgac
    25201 aggtcgcgag gtggaggggc atcgcaaggt ctgggaaatt ctaaagggaa taggtaacaa
    25261 agccagccga gccgagtcgg ctgcctagcc gggctttgcg gccttaacgg acacaggcgt
    25321 gaaggtgaag acaggaccgt ctactcggta cccaatcatg agcttgccac gccctgtcac
    25381 gcttcttccc gtgcatctgc accgcgacgc tacggccgtg tctgctcacg ttcataatcc
    25441 cttagtagtt caccgttcta tgcagacttc tctctactcc atcgcctaaa taaagtatca
    25501 caagcccata ttcggttgta attcgctcat ttcatgaagc tgttccaagc ctaagaagct
    25561 tggatcgaga ggtaacgcat cagtggacag atcccacagc atcaagcctt caaacacatt
    25621 gctgtcagtt cggaacgcat tcgccgtggg cccttcctgc cgctggaagg taaacggcag
    25681 ctctgatgag accccgtgag cgtggccatt cccataggat gttgaagagc ttgagttata
    25741 ggttagagtt tcagtcgatg gcatggatcg tgtctgtgtg cctgatctag ccagtgttgc
    25801 ctggacatga tctactagta tacccaattg atgcgctccc gtctctgcca tgacgctacc
    25861 tagagacatc atctcgagtt ggcgccgggc ctccttgata gctcgcaggc actggctttg
    25921 ggagatatcg atcatgtttg gagacagcgg gctatgcagg ctgaagaaat tgatgtgttc
    25981 cagatcttgc atgccattcg aatcacaggc ttgtagtatg cacaggctca agactaccgc
    26041 cgtctcaaaa tgatagaaaa taaccaacga tagcttggtc tggttgaagc tcatcattgc
    26101 atgcagtgat gtgacgcttt ggaataagcc catcgcagcg gtggccagtg tgtgccggtg
    26161 ctgggtgacg agggccatcc tggaatttgg caggctgcgt aggtgatgct ggtctaaacg
    26221 gagcagttgc ctgaagttgt gcatgactga ctcgaagaga gcgacatgga acaatactct
    26281 ttggcgagga agttcgggta tgtgcttgtc ccaatcggtg ttcggttcca aggcaaacgg
    26341 ggcagggagt tctggaagga actcattaca aaacctctga taacgttctt cagcaataac
    26401 gggatcgtac ggccgagccc caggggcgct attgccggct tcgagcttct tccagaaccg
    26461 taccagttgt gcttgaagta ctctctcggt gaacaggtcc ggtgcttgga ggttggcgat
    26521 ggtggggtgc agatgcatct gcggcagact tacggtgcag tacgcatcta caagaaacgg
    26581 aacgcggtca agggcttttg caaggcgact aacgacatcg ttagcatatg aagggagaat
    26641 tcggattccc gtaaactaac tagtcccaaa cgtacaggtt gcagaacatc ctgcgccgca
    26701 attctctttc tagatcgtcc atgccatcgt cgccccgctt cggaggctcc ctatggagtc
    26761 ctacctcctg agcttctctg atggcgcaac acagagtagc ccaggacaac ttgatgcggc
    26821 tgtcgcattc ataacacatg gccgtaaaag ccatgtactg aacccgcacg agcgacccac
    26881 gtagcactgc ggcgttgcag atgccttcaa gtcgtccagc gagccggtca cagttactcc
    26941 gaatatcaga cagtggtcta cccttgatcg tatctacagt atacttttgc gacggtagga
    27001 agtgggaagc gtatgcgcag attcgcagca tcaagacagc gaactccagg tctgcgaccc
    27061 ggcttattgt atccattttc caccagtcct cgtattgtgc aagcaggcga ggcggatgga
    27121 cgatctggtt gatccaattg atgtcttcga agaagtactg tatcaggaag tccacgatgc
    27181 ctcgagctgg cagatccttt agttcttgtt ggacgtcgtt gatgagggtg gacggcatca
    27241 tcgtgttgta ctcatgtggt ttgctcctgt cgtgcaatcc gcacttgaca catatatcag
    27301 cagggataca taggcaggtg gacacacaac ggggggtggc acagctgcga gaatttcaag
    27361 gcaggagaaa cgaagaccag caccccgggt ttactcactt ggcgtaggag ggcccatgta
    27421 ttggattcgc tttcttcaaa gtacccgtaa acgttgacca gtgttggcag ggcttggttg
    27481 tttctgcttt cggatctctc ttccccactc tccatctctt cccagggtgg gcttgcacgt
    27541 cgttctgcca tacccgcggt aggatcgtca aattgcaaca ttttattgcg ataagaatct
    27601 gattcgtgcg taggactgtc tgtggttcta gaaacccgtg gttgaggttt cgatacatag
    27661 gtacatagtt cgggacgacg tcttcgtgtg caatggtcgc aaggatattg tcggttacac
    27721 tagcagaaga ttttggtgtc agtttcgggg ttggggcgtg cgacgccttg cgtacctttt
    27781 gtttcttcga gtagcaaggt atgcaggaga gtacggcacg ttttcgtagt gccttttctg
    27841 acattgtccg gtcggactta tgaaaagcaa tggcgaatgg aatcttctga gcgacgctgg
    27901 ctctacgccg tgagtaacaa atgggcgatg tgtgtaactt tactctgccg ggtatgagag
    27961 tccaagctac ctaggcagta acgaactgct gatctatgtc cctctttgat ccgctccgct
    28021 tactcttcac actgtgttat tcagcattat tcataagtaa gaatctgcat cgacgccctg
    28081 tcactaggca ctgcatgtag ttgatagggt gaacgcagtg agattttggc gtctttggaa
    28141 gcggctgcgg aacgggacga cccccagcaa agattccaga agtctcatat tcttcgatta
    28201 caatctgtag aagcttgaaa agaagcgcac tgtacgttct atgtgtatgt aaagtaaaaa
    28261 gaaagcgcaa atgtgccgct actataggta ctcatccaat gaccgttcta acccttcctt
    28321 gaatccgata gcctagacta gactagtttg aagccgccgg gaaccaattc ctgaaacacg
    28381 cgggtcgggt cgtacttcct actggccgcc tgcagcttac tgtaagtcac agccccataa
    28441 ctttgcagcg gcatctgcgt gctgaaggca tcgttaagga agtaaaaagg taggtgcaag
    28501 gcctgagact tggtgtactc ttcaacctca gctagggcgt ccagcatgat actctccgct
    28561 tcagcgtcat cttgggccaa gttccatcct gagctaacca cgaaccctat aagaactctt
    28621 gttagtcggc aataccaaga ggagtgcttc ctacgtacac agctgcggct ggtccgcaac
    28681 gcccatcgga tccgatccgc gtgcacgggc ctcctccacc atagatactg agattggctg
    28741 tggcataagc atgatatctc caccttcgag ctttcgcatt cgcgggatgt atttgtggca
    28801 tatttgttca atctccaaat aggcctcctt gtcgtacaac aagtctgtgg tggcataggt
    28861 aaacctggtc atgttgtagg gaatcggtgc tgtcaccatg gccgcaaacg tgtcccaaac
    28921 ctgcgttaag tcttggataa ctggaatatc gtaaaaagct tcgaacgctt cgggcctctc
    28981 cacaggttcc agataggaaa actgcgcgac aactgcgtcc gcgataagcc cgacataagg
    29041 caagatggca gacttcttgt ccagctgacc cttcgcttgg tagtccgcca aggcagccat
    29101 gaactgcgct gaggcatttc ctgggaagat catggaacct ccccatatct taccgagtgg
    29161 gtacgtcctc tgtacgatat gcgtaacaat gcctgttgat tgtaagcaac atgctgtaga
    29221 tgcggacgag gacaccaacc aaaattgttc gcgccagctt tgacggcaaa gtacagatca
    29281 gaattttcct cctcactggc gatgacgatg gagccatcag ccagaaccat ttcatacgag
    29341 agcacatttt gtgcagccca accataagca ttagataagt gcgaaagccc acctgcagca
    29401 attcagtatg ttcgtcatat ccgaaggttg cacaacagct tacctccaag ggtgagagcc
    29461 aacccaacgc tgccggtgcg gccgccaacg acggtccgtc cctgtgcgtt cacgtgtcga
    29521 tagacatctt gccagaggtt accaaatccg gagcgctggg tttgagcgtc tgcattatac
    29581 tccaacgtct tgatgccagc caatgaaatg aggacgcccc cgtcaatgtt ggcgaagtac
    29641 tccattggcg aatgccctcc gcttcggatg gcaaatttcg cctgtacgaa agtggcgacc
    29701 ttgacgccta gagaaacacc tttaacatca ttcggtgtat agatgcacgc tgggttcttt
    29761 ggtgccgttg ctgaactgga agttgatgtc agtccagaac ggatgccgga tgtggacatt
    29821 cactcacgcg tgtgccttat cgatctgcgt atacagttcc ccatcactag gaaacacgac
    29881 tgcagtctga ttggatgctt ccagaattgc gcaagcgaga tgtactcctc cagtgtgtct
    29941 ggtttctccg tttattgctg cagggtttat tgcattcgat ttcaagaact tgtttaagtt
    30001 ctgagcttct tggcgatgcg gtccagaatg tccgacgacg gttggggtaa tcccaaggct
    30061 caacaaattc aagataatga aacgcatctt gtcagattgg cgtgatgtca gtcaatgctg
    30121 agaaatgaaa gagaactaaa tgaattgtta gacaaactgt ttggatgagc tctcgtgtgt
    30181 tcttttatcc aactccaagc acgtcaacat atatactaat cctctttccc tccatcttgg
    30241 ctcggccttg aactaaaacg ccacgactac cagcaaacaa gcctaagggt ccatcagcgg
    30301 gcgtaaccac agtggagaca gctacgtctg cgtaaaaccc tccacgatgc tcaccaagta
    30361 ccatgggagg atctgatatc caagagacat gacgcagctg aagaaagtcg ccccagggcg
    30421 ccttacggat ttaaccgatc ggccgatttt tctcggctct accaccaaca ggcgtggcgc
    30481 cacattttaa cgaatgttcg gctgactcag attacagatt cggctcgaag actagcgttc
    30541 taccactggg catccggtag atgttccttg gtgtgctctg aaggttgggt acgacgagga
    30601 ctttgcaccg aagctctgaa gttaccatgt caaagctcaa tggcacttac gagctttcac
    30661 tgtcgctctg aattcagatt atgtttgtcc ctggcaatat gggctggctc gtgctgagtt
    30721 gcggcctttt tgttgcctac tgggttctac tggccatcta ccgccttcac ttccacccgt
    30781 tatcacgata tcggggacca agggtagccg cagtgtcgaa ctcatggtac gagtggtatt
    30841 ggaattatca tctcaacgga caaatgatat ttgagattca gaggttacac aagcaatacg
    30901 gtaagctaga agcctgcttg gagaccgcac attgctaacg actagctcag gaccggtggt
    30961 acggataggc gtgaacgatc tcagcataga cgaccctgaa gtctatcagg cgatgaccaa
    31021 agtgagctcg ggcttcacga aagatcctca tttctatcga tgcatctcgt ttccaggaac
    31081 gtcgattgga gagaccgatc ccgcaaagag ccgaattcgt cgcaaagtgc taacacccgc
    31141 tctgtctggc acccgagtcc aagagctcgc ccccgcgatc ctcggtaagg tagaacggct
    31201 actaagaagg gtggacctct gtgcacagtc tgcaaagacc atctgcatca ccagcgcttg
    31261 caaagcactt accatggata tcatctccaa gattgttctc gggcgtgaga ttggatgcat
    31321 cgaagagccc gacttcagaa acagtttcat cgagaacttg aatgcagctt tcgaaacggg
    31381 atggatcgca actgccttcc ccaggttagc tacgctcgca ctctggatgg cttcgatgag
    31441 cgacttctcg gtcattccta atcctcttat cgatttcaaa cgggtgaggc gggtgcggct
    31501 actcactcat agaccacatt gctaacaaca tgtgcagaaa tgtcgagcca tcaccaagag
    31561 ctacctggaa gttttcgata cacattcaga cgtctacgta gcccgcaaag acgtcaacgt
    31621 gccatcagcc attgcaaccc atgccgacag atcagctgtg atagacatgc tcatggatcc
    31681 cctcaccgtc aaaggccaca ccgtaccaag cctagaacag ctaaacgacg aggctgtgat
    31741 acttctcacc gcaggtaacg acaccacttc gaactcgatg atcttcggtc tctatcaaat
    31801 ctgcaacaac atgtgtgtat acaaaaccct attccaggaa ctgcagggac gctttccctc
    31861 agtcgaccag cagatcacct acgaagatgc aaagcagctc ccgtatctag tgtgtaaccc
    31921 acccatcacc tccgctcttc gagtcaagct caccacgtcg tgtgtacaga cagctaccat
    31981 caaagagatc ttacgactag gtacccctct acctggtcgt ctcccacgct tgatcccatc
    32041 ttccggtttt caactctacg gtcaggacct gcctccgaaa gtaagatgat tcctcaaccc
    32101 gccttgcatc ccacaccgct gacgcaccaa cagacgagca tccatacatc gccctaccta
    32161 ctcaatcgcc atcccagcat ctgggataac ccaaacgact tcaaccctga cagatggctc
    32221 aggaagaatt cccgagacct ggacaagtat cttgcaacct tcaacagggg tgcgagacaa
    32281 tgtctcggca aggagtgggt acactcctat caaatcgcag gcttgtggca agattactaa
//
