LOCUS       BGC0002518             10561 bp    DNA     linear   BCT 02-NOV-2019
DEFINITION  Pseudomonas sp. SZ57 contig_2, whole genome shotgun sequence.
ACCESSION   BGC0002518
VERSION     BGC0002518
KEYWORDS    .
SOURCE      Pseudomonas sp. SZ57
  ORGANISM  Pseudomonas sp. SZ57
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
COMMENT     The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Stallforth Lab HKI Jena.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:53:20
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..774)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_235652.1"
                     /locus_tag="GE543_00945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="MQQ32957.1"
                     /transl_table=11
                     /translation="MNTAQHFEYHDDPRFYLQLAKLVSSTGDDTFAGHMLQLVDSLVPI
                     HGLGLSEWTLDLRESSISRINPLGSAGLKHDPPGGETTGHPLLPSILHMQDPLLIQLKT
                     PLSAQLPQHNTHQCNLVSSHGERRLIICFYRLTALRAFSLTELSLLKSLSDTLLPLVEH
                     HAQSLVQSSNNATRLEPEPGSLDQAFSGRLAQDSVTLSAREQEVCLGLLTGGTVAEMAQ
                     RLKVKNSSVETYLKRATAKLGVSGRHGLARWMAGD"
     protocluster    1..10561
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1063:10561]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1064..10561
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..10561
                     /SMILES="NC([*])C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10561
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002518"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10561
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..774)
                     /locus_tag="GE543_00945"
     gene            1064..10561
                     /locus_tag="GE543_00950"
     CDS             1064..10561
                     /NRPS_PKS="Domain: Condensation_Starter (6-307). E-value:
                     5.4e-96. Score: 313.3. Matches aSDomain:
                     nrpspksdomains_GE543_00950_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (471-860). E-value:
                     2.7e-101. Score: 330.9. Matches aSDomain:
                     nrpspksdomains_GE543_00950_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (962-1025). E-value: 7.3e-26. Score:
                     82.1. Matches aSDomain: nrpspksdomains_GE543_00950_PCP.1"
                     /NRPS_PKS="Domain: Condensation_Dual (1076-1371). E-value:
                     1.1e-133. Score: 436.9. Matches aSDomain:
                     nrpspksdomains_GE543_00950_Condensation_Dual.1"
                     /NRPS_PKS="Domain: AMP-binding (1535-1922). E-value:
                     4.2e-102. Score: 333.6. Matches aSDomain:
                     nrpspksdomains_GE543_00950_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2024-2091). E-value: 3.3e-27.
                     Score: 86.4. Matches aSDomain:
                     nrpspksdomains_GE543_00950_PCP.2"
                     /NRPS_PKS="Domain: Condensation_Dual (2138-2423). E-value:
                     1.4e-122. Score: 400.5. Matches aSDomain:
                     nrpspksdomains_GE543_00950_Condensation_Dual.2"
                     /NRPS_PKS="Domain: AMP-binding (2587-2986). E-value:
                     6.3e-118. Score: 385.7. Matches aSDomain:
                     nrpspksdomains_GE543_00950_AMP-binding.3"
                     /NRPS_PKS="Domain: PCP (3093-3159). E-value: 8.6e-25.
                     Score: 78.6. Matches aSDomain:
                     nrpspksdomains_GE543_00950_PCP.3"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     188.5; E-value: 4.1e-57)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_235653.1"
                     /locus_tag="GE543_00950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="MQQ32958.1"
                     /sec_met_domain="Condensation (E-value: 1.3e-51, bitscore:
                     162.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-126, bitscore:
                     408.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.4e-16, bitscore:
                     46.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLASSAATFPLTAAQRDVWLDQISRGDSPLYNIGGYLQLSGAVDP
                     ATLHKALEQLVCAHEVLRTVLMPGAAEDGMPLQSYAARLPVSLPLHDVSGHPEPEQAAR
                     ALINDNMRRPYGLDGSPLLDFCLIRLADDQHWLAGQAHHLILDGWGFGLLFKSLGELYS
                     ALMAGKDLELVAPGYSDFIADDARYQASQRYSLDRAYWLEKYRDLPEPLLVSRYHNRRA
                     NDPAPSHACVQPLPGNLHARMKQFAERHNASAFHVLLAVLHVYFTRTAQRDEWIVGLPL
                     LNRSGARFKATLGHFAQVSAVRMAFDEGLDFGALVVEVRSALKRDFRHQRFPLSELNRS
                     LELSREGRAQLFEVSMSYELEDHGYCYTDAQAQTVKVSNGYEATPLAVHLRSNSCNDEA
                     SLHLVHHRAWIDDDEASAIAGRLLHILEQGLENPSLKIQNFHLSEPAEQLQLQAWNQTE
                     SVAGDEQLIHRRIEQQARTRPYAVAAIFQGQHLTYAQLNRQANALAQRLIYQGVRPDDR
                     VVIVSRRGLETLVGLLAVLKAGAAYVPIDPSHPRERLHYLLTDSAPVVVLTLSSLIERL
                     PPLAVPLIELDHCIDGQGAENNPQVAGLGSDNLVYVIYTSGSTGQPKGVMVEHRTLANL
                     VDWHCQAFDVKAGSHTSCLAGFGFDAMAWEVWPTLCAGATLHVAPVQDGGEDIEAMLDW
                     WRAQPLDVSFLPTPVAEYAFSQNQDHPTLRTLLIGGDRLRQFTHNRRYAVVNNYGPTET
                     TVVATSGQVLATGSLHIGGPIANTRVYVLDKHLQAMPVGVPGELYIGGEGVARGYLNQP
                     QLTDQRFVADPFSDVAQARMYRSGDLVRWNDDGTLDYLGRNDDQVKIRGMRIELGEIES
                     VLASLEGVKDAVVLVRDLHLLAWFTETVTVDTDTLAAAMRARLPGYMVPRAFTRLASLP
                     LTANGKLDRRALPDPDPAYLLGNAYEAPQGEVEIAMAAIWAQVLGIERVGRHDNFFELG
                     GHSLLAVSLVEQLRKAGLKADVHVLLSQPTLAALAACQTDVSTFKVPANLIPAGCKQIT
                     PGMLSLVALEQPAIDRIVASVPGGAANVQEIYPLAPLQEGILYHHLTAEQGDPYLLQWR
                     LAFDTPERLYSWAAALQEVIDRHDILRTSVVWQGLESPQQVVWRNAELTVQAIEFEADD
                     PETPVIDRLQRQFDARHHRLDLTQAPLMRLVHAQQSSSGETVAILLFHHLVLDNTAMEI
                     VSREMQALLFGHRYDLKTPVPYRNYVAQVRLANDEASHTAFFTEMLGDVDEPTLPFGIQ
                     DVHADGSGIEEERRALDPELALRLREQARQLGVSAASLMHVVWARVLGVLANRRDVVFG
                     TVLLGRMGGEGADRALGVFINTLPLRVDTAQDTRSAVKAVHAKLSALIAHEQASLVLAQ
                     GCSAVASGSPLFSALLNYRHSAEVKPQDGEGLWQGVRVLGGDVRSNYPLTLCVDDLGEG
                     FDLHMLAQQGMGAERITGWVLNTLEHLLDTLEQALPLRLESVAILDAAERNHLLLDFNG
                     SEQPFPQDCTVNALIEEQAASQPDSPAVIQGGHVLTYAQLNQRANRLAHYLIDLGVKTD
                     ERIALCLHRGPERLVAMLAVLKAGAAYVPVDPVYPAERVAYLLQDSAPRVVLTENSTHE
                     LAGDTARVNIEQADWLGSSGNNPCVAALDEQKLAYVIYTSGSTGQPKGVMVEHCTLVNL
                     VHWHCQAFALQAGSHTASVAGFGFDAMAWEVWPALCSGAVVHLPPAEVGNEHVDELLDW
                     WLEQPLQVGFLPTPVAEQAFRRSRQHPTLRTLLIGGDRLRQFDSDPGFAVINNYGPTET
                     TVVATSGAMQPGGPLHIGGPIANTRVYVLDEQLQPVPVGVIGELYIGGAGVARGYLNRP
                     QMTEERFIADPFSAATQARLYRSGDLVRWNADGSLDYLGRNDDQVKIRGMRIELGEIES
                     VLASQAEVQDAVVLVRGERLLAWFTENAPVEPEVLREALRARLPAHMVPLAFTRLDALP
                     LTSHGKLDRRALPDPELEALTSQAYAAPVGATETLMADLWAHVLGLEKVGRHDNFFELG
                     GHSLLAVSLVERLRNAGLSVDVRVLLGQPTVAALAASVGKGREIPTPLNRVPAGCTHIT
                     PDLLSLSQLDQTTIERIVATVPGGAANVQEIYPLAPLQEGILYHHLTAEQGDPYLLQLR
                     MNVDSPERLEAVAAALRKVIARHDSLRTAIVWEGLETPQQVVWRQADLLVERVTLAQID
                     TPAGAARMDLSCAPLIRLAYCPDAEGPGLSATLRFHHIVVDATALEVMREEMLAHLRGE
                     PGPTQPAVPYRNYVAQARLGVSEAEHEAYFREQLGDIDEPTLPFDLRDVQGDGSCIEEA
                     QQVLPDALLQRLRSQARQLGVSVASLLHLAWARVLGAATGNDRVVFGTVLLGRLQGGAG
                     ADRGMGMFINTLPLRIDLGNLSVRDGARATHARLAALLGHEHASLAQAQRWSGVAAPLP
                     LFSAILNYRHAAGQARQDAQLDAWQGLEILTSEKHTNYPLSLNVDDLGDSLRLSVTVPP
                     RVGAQRICAYVQQTLTAMLDALEGQPDLPVQHLSVLGAEERQRSLVEFNATAIHHDLQQ
                     TLHGLFEAQAVRTPQAIALRAGRAQLSYRQLNEQANCLAHHLIDLGVRPDQRVAICVER
                     GLSMVIGLLAILKAGGAYVPLDPSYPRERLQYMVKDSTPVALLVQAGTRDLLDDEHALR
                     IDLDSVTWDAQRDQNPRVPGLTAEHLAYVIYTSGSTGTPKGVMVEHRNVSNLVQWSSRL
                     CPPTSGTVMLQKTPISFDASVWEIFWPLSSGIALVLARPDGQRDPAYLAQVIQERQVSV
                     VQFVPALLQQFLDLPQSSACSSLTDIVCGGGELTVEMAAQLRKRLPEVRLHNVYGPTET
                     TVDCSVWTLQADEAVPDTALPIGRPISNTRLYVLDAHDQPVPQGVIGQLHIGGAGVTRG
                     YLNLPKTDAERFIDSPFVAGDRLYRSGDLVRQRADGNLEFLGRNDDQVKIHGLRIEPGD
                     IQACLISHPGIEQAVVLVRDEQPGGQRLVAYYTGTQLSVETLREVLRAQLPDYMVPALF
                     VHLDEMPLSPNGKLDRKALPAPGQDALLTRPYEAPQGETEALLARLWSELLGVGQVGRH
                     DNFFELGGHSLLAVSLTARLRQEGIEADVRALFEQPTLAGYAAITENMEITL"
     aSDomain        1082..1984
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_Condensation_Starter
                     .1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="5.40E-96"
                     /label="GE543_00950_Condensation_Starter.1"
                     /locus_tag="GE543_00950"
                     /protein_end="307"
                     /protein_start="6"
                     /score="313.3"
                     /tool="antismash"
                     /translation="ATFPLTAAQRDVWLDQISRGDSPLYNIGGYLQLSGAVDPATLHKA
                     LEQLVCAHEVLRTVLMPGAAEDGMPLQSYAARLPVSLPLHDVSGHPEPEQAARALINDN
                     MRRPYGLDGSPLLDFCLIRLADDQHWLAGQAHHLILDGWGFGLLFKSLGELYSALMAGK
                     DLELVAPGYSDFIADDARYQASQRYSLDRAYWLEKYRDLPEPLLVSRYHNRRANDPAPS
                     HACVQPLPGNLHARMKQFAERHNASAFHVLLAVLHVYFTRTAQRDEWIVGLPLLNRSGA
                     RFKATLGHFAQVSAVRMAFD"
     aSModule        1082..4138
                     /complete
                     /domains="nrpspksdomains_GE543_00950_Condensation_Starter.1
                     "
                     /domains="nrpspksdomains_GE543_00950_AMP-binding.1"
                     /domains="nrpspksdomains_GE543_00950_PCP.1"
                     /locus_tags="GE543_00950"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1088..1129
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0001"
                     /evalue="1.20E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="GE543_00950"
                     /protein_end="22"
                     /protein_start="8"
                     /score="11.6"
                     /tool="antismash"
                     /translation="FPLTAAQRDVWLDQ"
     CDS_motif       1148..1264
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0002"
                     /evalue="1.20E-13"
                     /label="C2_starter_024-063"
                     /locus_tag="GE543_00950"
                     /protein_end="67"
                     /protein_start="28"
                     /score="43.6"
                     /tool="antismash"
                     /translation="PLYNIGGYLQLSGAVDPATLHKALEQLVCAHEVLRTVLM"
     CDS_motif       1484..1549
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0003"
                     /evalue="1.00E-08"
                     /label="C3_starter_134-155"
                     /locus_tag="GE543_00950"
                     /protein_end="162"
                     /protein_start="140"
                     /score="28.0"
                     /tool="antismash"
                     /translation="AHHLILDGWGFGLLFKSLGELY"
     CDS_motif       1883..1972
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0004"
                     /evalue="6.20E-10"
                     /label="C5_starter_265-294"
                     /locus_tag="GE543_00950"
                     /protein_end="303"
                     /protein_start="273"
                     /score="31.5"
                     /tool="antismash"
                     /translation="EWIVGLPLLNRSGARFKATLGHFAQVSAVR"
     CDS_motif       2027..2137
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0005"
                     /evalue="2.00E-12"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="GE543_00950"
                     /protein_end="358"
                     /protein_start="321"
                     /score="39.6"
                     /tool="antismash"
                     /translation="ALKRDFRHQRFPLSELNRSLELSREGRAQLFEVSMSY"
     aSDomain        2477..3643
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_AMP-binding.1"
                     /evalue="2.70E-101"
                     /label="GE543_00950_AMP-binding.1"
                     /locus_tag="GE543_00950"
                     /protein_end="860"
                     /protein_start="471"
                     /score="330.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EQQARTRPYAVAAIFQGQHLTYAQLNRQANALAQRLIYQGVRPDD
                     RVVIVSRRGLETLVGLLAVLKAGAAYVPIDPSHPRERLHYLLTDSAPVVVLTLSSLIER
                     LPPLAVPLIELDHCIDGQGAENNPQVAGLGSDNLVYVIYTSGSTGQPKGVMVEHRTLAN
                     LVDWHCQAFDVKAGSHTSCLAGFGFDAMAWEVWPTLCAGATLHVAPVQDGGEDIEAMLD
                     WWRAQPLDVSFLPTPVAEYAFSQNQDHPTLRTLLIGGDRLRQFTHNRRYAVVNNYGPTE
                     TTVVATSGQVLATGSLHIGGPIANTRVYVLDKHLQAMPVGVPGELYIGGEGVARGYLNQ
                     PQLTDQRFVADPFSDVAQARMYRSGDLVRWNDDGTLDYLGRNDDQVKIR"
     CDS_motif       2660..2701
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0006"
                     /evalue="6.90E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="GE543_00950"
                     /protein_end="546"
                     /protein_start="532"
                     /score="19.1"
                     /tool="antismash"
                     /translation="LAVLKAGAAYVPID"
     CDS_motif       2894..2950
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0007"
                     /evalue="1.60E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="GE543_00950"
                     /protein_end="629"
                     /protein_start="610"
                     /score="32.7"
                     /tool="antismash"
                     /translation="YVIYTSGSTGQPKGVMVEH"
     CDS_motif       3302..3331
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0008"
                     /evalue="5.90E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="GE543_00950"
                     /protein_end="756"
                     /protein_start="746"
                     /score="9.4"
                     /tool="antismash"
                     /translation="NYGPTETTVV"
     CDS_motif       3431..3520
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0009"
                     /evalue="1.50E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="GE543_00950"
                     /protein_end="819"
                     /protein_start="789"
                     /score="55.6"
                     /tool="antismash"
                     /translation="PVGVPGELYIGGEGVARGYLNQPQLTDQRF"
     CDS_motif       3542..3565
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0010"
                     /evalue="2.10E+01"
                     /label="C4_dual_169-182"
                     /locus_tag="GE543_00950"
                     /protein_end="834"
                     /protein_start="826"
                     /score="-1.1"
                     /tool="antismash"
                     /translation="VAQARMYR"
     CDS_motif       3608..3673
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0011"
                     /evalue="6.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="GE543_00950"
                     /protein_end="870"
                     /protein_start="848"
                     /score="37.4"
                     /tool="antismash"
                     /translation="YLGRNDDQVKIRGMRIELGEIE"
     CDS_motif       3866..3892
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0012"
                     /evalue="2.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="GE543_00950"
                     /protein_end="943"
                     /protein_start="934"
                     /score="4.5"
                     /tool="antismash"
                     /translation="GKLDRRALP"
     aSDomain        3950..4138
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_PCP.1"
                     /evalue="7.30E-26"
                     /label="GE543_00950_PCP.1"
                     /locus_tag="GE543_00950"
                     /protein_end="1025"
                     /protein_start="962"
                     /score="82.1"
                     /tool="antismash"
                     /translation="EIAMAAIWAQVLGIERVGRHDNFFELGGHSLLAVSLVEQLRKAGL
                     KADVHVLLSQPTLAALAA"
     aSDomain        4292..5176
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_Condensation_Dual.1"
                     /domain_subtypes="Condensation_Dual"
                     /evalue="1.10E-133"
                     /label="GE543_00950_Condensation_Dual.1"
                     /locus_tag="GE543_00950"
                     /protein_end="1371"
                     /protein_start="1076"
                     /score="436.9"
                     /tool="antismash"
                     /translation="QEIYPLAPLQEGILYHHLTAEQGDPYLLQWRLAFDTPERLYSWAA
                     ALQEVIDRHDILRTSVVWQGLESPQQVVWRNAELTVQAIEFEADDPETPVIDRLQRQFD
                     ARHHRLDLTQAPLMRLVHAQQSSSGETVAILLFHHLVLDNTAMEIVSREMQALLFGHRY
                     DLKTPVPYRNYVAQVRLANDEASHTAFFTEMLGDVDEPTLPFGIQDVHADGSGIEEERR
                     ALDPELALRLREQARQLGVSAASLMHVVWARVLGVLANRRDVVFGTVLLGRMGGEGADR
                     ALGVFINTLPLRVD"
     aSModule        4292..7336
                     /complete
                     /domains="nrpspksdomains_GE543_00950_Condensation_Dual.1"
                     /domains="nrpspksdomains_GE543_00950_AMP-binding.2"
                     /domains="nrpspksdomains_GE543_00950_PCP.2"
                     /locus_tags="GE543_00950"
                     /monomer_pairings="Leu -> Leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4301..4342
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0013"
                     /evalue="7.00E-07"
                     /label="C1_dual_004-017"
                     /locus_tag="GE543_00950"
                     /protein_end="1093"
                     /protein_start="1079"
                     /score="21.5"
                     /tool="antismash"
                     /translation="YPLAPLQEGILYHH"
     CDS_motif       4367..4480
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0014"
                     /evalue="1.30E-16"
                     /label="C2_dual_024-063"
                     /locus_tag="GE543_00950"
                     /protein_end="1139"
                     /protein_start="1101"
                     /score="53.1"
                     /tool="antismash"
                     /translation="YLLQWRLAFDTPERLYSWAAALQEVIDRHDILRTSVVW"
     CDS_motif       4700..4765
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0015"
                     /evalue="4.00E-08"
                     /label="C3_dual_135-156"
                     /locus_tag="GE543_00950"
                     /protein_end="1234"
                     /protein_start="1212"
                     /score="26.0"
                     /tool="antismash"
                     /translation="FHHLVLDNTAMEIVSREMQALL"
     CDS_motif       4799..4834
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0016"
                     /evalue="1.30E-04"
                     /label="C4_dual_169-182"
                     /locus_tag="GE543_00950"
                     /protein_end="1257"
                     /protein_start="1245"
                     /score="14.8"
                     /tool="antismash"
                     /translation="PYRNYVAQVRLA"
     CDS_motif       5078..5170
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0017"
                     /evalue="8.80E-16"
                     /label="C5_dual_260-291"
                     /locus_tag="GE543_00950"
                     /protein_end="1369"
                     /protein_start="1338"
                     /score="50.0"
                     /tool="antismash"
                     /translation="DVVFGTVLLGRMGGEGADRALGVFINTLPLR"
     CDS_motif       5219..5290
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0018"
                     /evalue="3.40E-06"
                     /label="C67_dual_14fromHMM"
                     /locus_tag="GE543_00950"
                     /protein_end="1409"
                     /protein_start="1385"
                     /score="19.8"
                     /tool="antismash"
                     /translation="KLSALIAHEQASLVLAQGCSAVAS"
     aSDomain        5669..6829
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_AMP-binding.2"
                     /evalue="4.20E-102"
                     /label="GE543_00950_AMP-binding.2"
                     /locus_tag="GE543_00950"
                     /protein_end="1922"
                     /protein_start="1535"
                     /score="333.6"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="EEQAASQPDSPAVIQGGHVLTYAQLNQRANRLAHYLIDLGVKTDE
                     RIALCLHRGPERLVAMLAVLKAGAAYVPVDPVYPAERVAYLLQDSAPRVVLTENSTHEL
                     AGDTARVNIEQADWLGSSGNNPCVAALDEQKLAYVIYTSGSTGQPKGVMVEHCTLVNLV
                     HWHCQAFALQAGSHTASVAGFGFDAMAWEVWPALCSGAVVHLPPAEVGNEHVDELLDWW
                     LEQPLQVGFLPTPVAEQAFRRSRQHPTLRTLLIGGDRLRQFDSDPGFAVINNYGPTETT
                     VVATSGAMQPGGPLHIGGPIANTRVYVLDEQLQPVPVGVIGELYIGGAGVARGYLNRPQ
                     MTEERFIADPFSAATQARLYRSGDLVRWNADGSLDYLGRNDDQVKIR"
     CDS_motif       5852..5893
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0019"
                     /evalue="1.40E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="GE543_00950"
                     /protein_end="1610"
                     /protein_start="1596"
                     /score="18.2"
                     /tool="antismash"
                     /translation="LAVLKAGAAYVPVD"
     CDS_motif       6077..6136
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0020"
                     /evalue="3.30E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="GE543_00950"
                     /protein_end="1691"
                     /protein_start="1671"
                     /score="34.8"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVMVEH"
     CDS_motif       6488..6517
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0021"
                     /evalue="5.90E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="GE543_00950"
                     /protein_end="1818"
                     /protein_start="1808"
                     /score="9.4"
                     /tool="antismash"
                     /translation="NYGPTETTVV"
     CDS_motif       6617..6706
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0022"
                     /evalue="5.90E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="GE543_00950"
                     /protein_end="1881"
                     /protein_start="1851"
                     /score="56.9"
                     /tool="antismash"
                     /translation="PVGVIGELYIGGAGVARGYLNRPQMTEERF"
     CDS_motif       6794..6859
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0023"
                     /evalue="6.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="GE543_00950"
                     /protein_end="1932"
                     /protein_start="1910"
                     /score="37.4"
                     /tool="antismash"
                     /translation="YLGRNDDQVKIRGMRIELGEIE"
     CDS_motif       7052..7078
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0024"
                     /evalue="2.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="GE543_00950"
                     /protein_end="2005"
                     /protein_start="1996"
                     /score="4.5"
                     /tool="antismash"
                     /translation="GKLDRRALP"
     aSDomain        7136..7336
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_PCP.2"
                     /evalue="3.30E-27"
                     /label="GE543_00950_PCP.2"
                     /locus_tag="GE543_00950"
                     /protein_end="2091"
                     /protein_start="2024"
                     /score="86.4"
                     /tool="antismash"
                     /translation="ETLMADLWAHVLGLEKVGRHDNFFELGGHSLLAVSLVERLRNAGL
                     SVDVRVLLGQPTVAALAASVGK"
     aSDomain        7478..8332
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_Condensation_Dual.2"
                     /domain_subtypes="Condensation_Dual"
                     /evalue="1.40E-122"
                     /label="GE543_00950_Condensation_Dual.2"
                     /locus_tag="GE543_00950"
                     /protein_end="2423"
                     /protein_start="2138"
                     /score="400.5"
                     /tool="antismash"
                     /translation="QEIYPLAPLQEGILYHHLTAEQGDPYLLQLRMNVDSPERLEAVAA
                     ALRKVIARHDSLRTAIVWEGLETPQQVVWRQADLLVERVTLAQIDTPAGAARMDLSCAP
                     LIRLAYCPDAEGPGLSATLRFHHIVVDATALEVMREEMLAHLRGEPGPTQPAVPYRNYV
                     AQARLGVSEAEHEAYFREQLGDIDEPTLPFDLRDVQGDGSCIEEAQQVLPDALLQRLRS
                     QARQLGVSVASLLHLAWARVLGAATGNDRVVFGTVLLGRLQGGAGADRGMGMFINTLPL
                     RIDL"
     aSModule        7478..10540
                     /complete
                     /domains="nrpspksdomains_GE543_00950_Condensation_Dual.2"
                     /domains="nrpspksdomains_GE543_00950_AMP-binding.3"
                     /domains="nrpspksdomains_GE543_00950_PCP.3"
                     /locus_tags="GE543_00950"
                     /monomer_pairings="Gln -> Gln"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       7487..7528
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0025"
                     /evalue="7.00E-07"
                     /label="C1_dual_004-017"
                     /locus_tag="GE543_00950"
                     /protein_end="2155"
                     /protein_start="2141"
                     /score="21.5"
                     /tool="antismash"
                     /translation="YPLAPLQEGILYHH"
     CDS_motif       7553..7666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0026"
                     /evalue="2.10E-13"
                     /label="C2_dual_024-063"
                     /locus_tag="GE543_00950"
                     /protein_end="2201"
                     /protein_start="2163"
                     /score="42.8"
                     /tool="antismash"
                     /translation="YLLQLRMNVDSPERLEAVAAALRKVIARHDSLRTAIVW"
     CDS_motif       7850..7915
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0027"
                     /evalue="2.30E-06"
                     /label="C3_dual_135-156"
                     /locus_tag="GE543_00950"
                     /protein_end="2284"
                     /protein_start="2262"
                     /score="20.5"
                     /tool="antismash"
                     /translation="FHHIVVDATALEVMREEMLAHL"
     CDS_motif       7949..7990
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0028"
                     /evalue="4.30E-07"
                     /label="C4_dual_169-182"
                     /locus_tag="GE543_00950"
                     /protein_end="2309"
                     /protein_start="2295"
                     /score="22.3"
                     /tool="antismash"
                     /translation="PYRNYVAQARLGVS"
     CDS_motif       8231..8323
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0029"
                     /evalue="1.60E-16"
                     /label="C5_dual_260-291"
                     /locus_tag="GE543_00950"
                     /protein_end="2420"
                     /protein_start="2389"
                     /score="52.3"
                     /tool="antismash"
                     /translation="VVFGTVLLGRLQGGAGADRGMGMFINTLPLR"
     CDS_motif       8372..8449
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0030"
                     /evalue="4.80E-09"
                     /label="C67_dual_14fromHMM"
                     /locus_tag="GE543_00950"
                     /protein_end="2462"
                     /protein_start="2436"
                     /score="28.7"
                     /tool="antismash"
                     /translation="ARLAALLGHEHASLAQAQRWSGVAAP"
     aSDomain        8825..10021
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_AMP-binding.3"
                     /evalue="6.30E-118"
                     /label="GE543_00950_AMP-binding.3"
                     /locus_tag="GE543_00950"
                     /protein_end="2986"
                     /protein_start="2587"
                     /score="385.7"
                     /specificity="substrate consensus: Gln"
                     /tool="antismash"
                     /translation="FEAQAVRTPQAIALRAGRAQLSYRQLNEQANCLAHHLIDLGVRPD
                     QRVAICVERGLSMVIGLLAILKAGGAYVPLDPSYPRERLQYMVKDSTPVALLVQAGTRD
                     LLDDEHALRIDLDSVTWDAQRDQNPRVPGLTAEHLAYVIYTSGSTGTPKGVMVEHRNVS
                     NLVQWSSRLCPPTSGTVMLQKTPISFDASVWEIFWPLSSGIALVLARPDGQRDPAYLAQ
                     VIQERQVSVVQFVPALLQQFLDLPQSSACSSLTDIVCGGGELTVEMAAQLRKRLPEVRL
                     HNVYGPTETTVDCSVWTLQADEAVPDTALPIGRPISNTRLYVLDAHDQPVPQGVIGQLH
                     IGGAGVTRGYLNLPKTDAERFIDSPFVAGDRLYRSGDLVRQRADGNLEFLGRNDDQVKI
                     "
     CDS_motif       9011..9052
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0031"
                     /evalue="6.40E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="GE543_00950"
                     /protein_end="2663"
                     /protein_start="2649"
                     /score="19.2"
                     /tool="antismash"
                     /translation="LAILKAGGAYVPLD"
     CDS_motif       9242..9301
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0032"
                     /evalue="3.20E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="GE543_00950"
                     /protein_end="2746"
                     /protein_start="2726"
                     /score="34.9"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGTPKGVMVEH"
     CDS_motif       9677..9703
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0033"
                     /evalue="1.00E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="GE543_00950"
                     /protein_end="2880"
                     /protein_start="2871"
                     /score="5.9"
                     /tool="antismash"
                     /translation="YGPTETTVD"
     CDS_motif       9818..9907
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0034"
                     /evalue="2.70E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="GE543_00950"
                     /protein_end="2948"
                     /protein_start="2918"
                     /score="38.9"
                     /tool="antismash"
                     /translation="PQGVIGQLHIGGAGVTRGYLNLPKTDAERF"
     CDS_motif       9989..10054
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0035"
                     /evalue="4.70E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="GE543_00950"
                     /protein_end="2997"
                     /protein_start="2975"
                     /score="31.6"
                     /tool="antismash"
                     /translation="FLGRNDDQVKIHGLRIEPGDIQ"
     CDS_motif       10259..10285
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE543_00950_0036"
                     /evalue="2.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="GE543_00950"
                     /protein_end="3074"
                     /protein_start="3065"
                     /score="4.5"
                     /tool="antismash"
                     /translation="GKLDRKALP"
     aSDomain        10343..10540
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE543_00950_PCP.3"
                     /evalue="8.60E-25"
                     /label="GE543_00950_PCP.3"
                     /locus_tag="GE543_00950"
                     /protein_end="3159"
                     /protein_start="3093"
                     /score="78.6"
                     /tool="antismash"
                     /translation="EALLARLWSELLGVGQVGRHDNFFELGGHSLLAVSLTARLRQEGI
                     EADVRALFEQPTLAGYAAITE"
ORIGIN
        1 tcaatcacct gccatccagc gtgccaggcc atgtcgtccg ctgacgccca gtttggcggt
       61 agcgcgcttg aggtaggttt ccaccgaact gttcttgacc ttgaggcgct gcgccatctc
      121 agccacggtg ccaccggtca gcaagcccag gcagacttcc tgctcgcgtg ctgaaagtgt
      181 gaccgagtcc tgtgcgagcc tgccactgaa ggcctgatcc agcgagccag gctccggctc
      241 gaggcgggtg gcgttgttgc tggactgaac aaggctctgc gcgtgatgct cgaccagcgg
      301 caacagtgtg tcggagaggc tcttgagcaa ggacaattct gtcagggaaa acgcccgcaa
      361 cgcagtcagc cgataaaaac agatgatcag ccgacgttca ccgtggctgg acaccagatt
      421 gcactggtgg gtgttgtgct gaggaagttg cgcgctcagc ggggtcttga gctggatcaa
      481 taacgggtcc tgcatgtgca gaatgctggg tagcagagga tggccggtgg tctcgccgcc
      541 gggagggtca tgtttcaggc ccgcactgcc gagcggattg atacgactga tgctgctctc
      601 acgcaggtcc agcgtccatt cactgaggcc aagcccgtga atgggcacca gcgaatccac
      661 caattgcagc atgtgcccgg caaaggtgtc gtcgcccgta ctggatacca gtttggccag
      721 ttgcagataa aagcgtgggt cgtcgtggta ctcgaaatgt tgcgccgtgt tcatcttgag
      781 ctttcctgat tccgaccgcg caaaaacgga ccatgtcgac tgctgcgcgg caactactga
      841 ttgcacttac tgatgagcca gatgatggca cttggtctcg gggtattcag cctaagcttt
      901 catcctgcgt ctgtaacaaa aaacagggac aggattgcaa tcggccgaaa gtgtatctgc
      961 accgacattt ggctgtacgg cactgtccgg gtttcagggg ccatacacag ctgggacggc
     1021 agtgcttaat ccgctgccta cctgccaaga aggaccttga gtcatgctcg cctccagcgc
     1081 cgcaacattc ccattgaccg ctgctcagcg cgacgtctgg cttgatcaga tcagccgcgg
     1141 tgactctccg ctttataaca tcggcggcta tctgcaactg tccggagcgg ttgacccggc
     1201 gaccctgcac aaggcgctgg agcaactggt ttgcgcacat gaggtgctgc gcaccgtgct
     1261 gatgccgggt gccgcagagg atggcatgcc gctgcagtca tatgcggctc gcctgccggt
     1321 gtccttgccg ttgcacgacg tcagcggtca ccccgaaccg gaacaggcag cgcgagcact
     1381 gatcaatgac aacatgcgcc gcccgtacgg gctcgatggc agcccattgc tcgacttctg
     1441 tctcatccgt ctggctgatg atcagcactg gctggcaggc caggcccacc acctgattct
     1501 cgatggctgg ggtttcggac tgttgttcaa gtctctgggc gagctttaca gcgcgttgat
     1561 ggcaggcaaa gacctcgaac tggttgcacc ggggtacagc gacttcattg cagacgatgc
     1621 gcgttatcag gcgtcgcaac gctattcgct ggacagggct tattggctgg aaaaataccg
     1681 tgatttgccg gagccgttgc tggtgtcgcg ctatcacaac cgccgggcga atgacccggc
     1741 gccgtcgcac gcctgtgtgc agccgcttcc cggtaacttg catgcgcgca tgaaacaatt
     1801 tgccgagcgc cacaacgcgt ctgcgtttca tgtactgctg gcggttctgc atgtctattt
     1861 cacgcgcacg gcgcaacgcg acgagtggat tgtcgggctg ccgctgctca atcgcagtgg
     1921 tgcgcgcttc aaggcgacgc tgggtcactt cgctcaggtc agtgccgtgc gcatggcctt
     1981 cgacgaaggg ctggacttcg gtgccttggt ggtcgaggtg cgcagcgcac tgaaacgtga
     2041 tttccggcat cagcgcttcc ccttgagcga gctcaatcgc agcctcgaat tgtcacgtga
     2101 gggaagggcg caactgttcg aagtatcgat gtcctacgag ctggaagacc atggttactg
     2161 ctacaccgat gcgcaggcgc agactgtaaa agtgtccaat ggctacgagg cgacgccgct
     2221 ggccgtccac ttgcgcagca acagctgcaa cgacgaagcc tcgctgcacc tggttcacca
     2281 ccgtgcctgg atcgatgatg acgaggcctc ggcgattgcc gggcgtttgc tgcacattct
     2341 ggagcagggg ctggaaaacc cgtcactgaa gattcagaac ttccacctct cagaacctgc
     2401 cgagcaattg caactacagg cctggaacca gactgaaagc gttgcgggcg acgagcaact
     2461 gattcatcga cgcatcgaac agcaggcccg tactcgcccc tatgccgtgg cggcgatatt
     2521 ccaggggcaa cacctgacct acgcgcaact taaccgtcag gccaatgccc tggctcagcg
     2581 tctgatctat cagggcgtac gccctgacga tcgcgtggta atcgtttcgc gccgtggcct
     2641 ggaaaccctg gtagggctgc tggccgttct caaggcgggg gcggcttatg tgcccatcga
     2701 tccgtcgcac ccgcgcgaac gcctgcacta tctgctcact gacagcgcgc cggtggtggt
     2761 actcaccctg tcttcgctga tcgagcgttt gccgccgctg gcagtgccgc tgatcgaact
     2821 ggaccactgc atcgacggcc agggcgccga gaacaatcct caggtagcgg ggctgggcag
     2881 cgacaatctg gtctacgtca tttatacctc cggttccact ggccagccca aaggcgtgat
     2941 ggtggagcat cgaaccctgg ccaacctggt tgactggcac tgccaggctt tcgatgtgaa
     3001 ggcgggcagt catacctcct gcctggccgg tttcggtttc gatgcgatgg cctgggaggt
     3061 ctggccgacc ctttgcgctg gtgcaaccct gcatgtggcg ccggtccagg acggtggtga
     3121 ggacattgaa gccatgctcg actggtggcg cgcgcaaccg ctggacgtga gctttcttcc
     3181 caccccggtg gccgagtacg ccttcagcca gaatcaggat catccgactt tgcgtacgct
     3241 gctgatcggc ggcgatcgcc tgcggcagtt cactcacaac cgccgttatg ccgtggtcaa
     3301 caactatggt ccgaccgaaa ccacggttgt tgccacctcc ggtcaggtgc tggccaccgg
     3361 ctcgctgcac attggcggcc ccatcgccaa cacccgtgtc tacgtcctcg acaagcactt
     3421 gcaagcgatg cccgtcggtg tacccggtga gctttacatt ggcggtgagg gtgttgcgcg
     3481 gggctatctg aaccagccgc aactcaccga ccagcgcttt gttgccgacc cgttcagcga
     3541 tgttgcacag gcgcgtatgt accgcagcgg cgatctggtg cgctggaacg acgacgggac
     3601 tctggattac ctgggccgta acgacgacca ggtgaagatt cgtggcatgc gcatcgagct
     3661 gggcgaaatc gaatcggtgc tggccagtct ggagggtgtc aaagatgcgg ttgtgctggt
     3721 tcgcgatctc catctgctgg cctggttcac agaaaccgtc acggtcgaca ccgacacgct
     3781 ggcagcggca atgcgcgcac gcctgccggg ctacatggtg ccgcgcgcct ttacccggct
     3841 ggcgtcgctg ccattgacgg ccaacggcaa acttgaccgt cgtgcgctgc ccgatcccga
     3901 cccggcgtat ctgctcggca acgcttatga agcaccacag ggcgaagtgg aaatcgccat
     3961 ggcggccatc tgggcacagg tgctgggcat cgagcgcgta gggcggcacg acaacttttt
     4021 cgaactgggc ggccattcct tgctcgccgt cagtctggtg gagcaactgc gcaaggccgg
     4081 actcaaggcg gatgtgcatg tgctgctcag ccagccgaca ctggccgctc tggcggcatg
     4141 tcagacggac gtcagcacct tcaaggtgcc ggcaaacctt attccggcag gctgcaagca
     4201 gatcactccg ggcatgttga gtctggtggc gctcgaacag ccagccattg atcgcattgt
     4261 cgccagcgta ccgggcggtg ccgccaatgt gcaggagatc tacccgctgg caccgttgca
     4321 ggaaggcatt ctctatcacc acctgaccgc agagcagggc gatccctatc tgctgcaatg
     4381 gcgtctggcg ttcgacacgc cggagcgtct gtacagctgg gctgcggcct tgcaggaagt
     4441 catcgaccgc cacgatatcc tgcgcacctc ggtggtgtgg caaggtctgg aaagcccgca
     4501 acaggtggtc tggcgtaacg ccgagctgac ggtacaagcc atcgagttcg aggccgatga
     4561 ccccgaaacg cctgtcatcg atcgtctgca acgccagttc gacgcccggc atcatcgact
     4621 ggatctgacc caggcaccct tgatgcgtct ggtgcatgcc cagcaatcgt cgagcggcga
     4681 aaccgtcgcc attctgctct tccaccacct ggtgctggat aacacagcga tggagatcgt
     4741 cagccgcgag atgcaagcgt tgctgttcgg ccaccgctat gacttgaaaa cgccggtgcc
     4801 gtatcgcaac tacgtcgcgc aagtacgcct ggccaatgat gaggcaagcc acacagcgtt
     4861 tttcactgaa atgctcggtg acgtcgatga gccaaccctg ccttttggca tacaggatgt
     4921 acacgccgac ggcagtggca tcgaggagga gcgacgggcc ctcgaccctg aactggcgct
     4981 gcggctgcgc gagcaggcac gccagctcgg ggtgagcgct gcaagcctga tgcacgtcgt
     5041 atgggcgcgg gttctgggcg tgctcgccaa tcgtcgcgac gtggtgttcg gcactgtgtt
     5101 gctgggacgc atgggcggtg agggcgctga ccgggcgctc ggtgtcttta tcaataccct
     5161 gccactgcgc gtggatacgg cgcaggacac tcgttcagcc gtcaaggcgg tgcacgcgaa
     5221 gctgtctgcg ctgatcgctc acgagcaggc ttcactggta ctcgctcagg gctgcagcgc
     5281 ggtggcatcg ggttccccgc tgttcagtgc gctgctcaat tatcgccaca gcgctgaggt
     5341 aaaaccgcag gacggcgaag ggctctggca aggcgtgcgg gtgctcggtg gcgatgtacg
     5401 cagcaattac ccgctgacgc tctgcgtgga cgatctgggc gaaggtttcg acctgcatat
     5461 gctggcacag cagggtatgg gtgccgagcg tattactggc tgggtgctca acacgctgga
     5521 gcatctgttg gacactctgg aacaggcgct gccgctgcgg ctggagagcg tagcgattct
     5581 cgacgcggca gagcgcaacc atttgttgct cgatttcaac ggcagcgagc agccgttccc
     5641 gcaggactgc accgtcaatg cgttgatcga agagcaggct gccagccagc cagacagccc
     5701 tgcggtgatt cagggcggtc atgtcctgac ctacgctcag ctcaaccagc gtgccaatcg
     5761 cctggcccac tatctgattg accttggcgt caaaaccgat gagcgcatcg ccctgtgcct
     5821 gcaccgtggt cccgaacgcc tggttgccat gttggcggtg ctcaaggccg gtgcggccta
     5881 cgtgccggtc gacccggtct atccggccga gcgtgttgcc tacctgctgc aggacagcgc
     5941 gccccgcgtg gttctgactg aaaactcgac ccacgagctg gccggcgata ctgcacgggt
     6001 gaacatcgag caggcggact ggctgggttc ttccggcaat aacccctgtg ttgcggccct
     6061 tgatgagcaa aaactggcgt acgtcatcta cacctccggc tccaccggcc agcccaaggg
     6121 cgtcatggtc gagcactgca cgctggtcaa tctggtgcac tggcactgtc aggcattcgc
     6181 tctgcaggct ggcagtcata cggcgagcgt ggccggtttc ggcttcgacg ccatggcctg
     6241 ggaagtgtgg ccagcgctgt gttccggtgc ggtagtgcat ctgccaccgg ccgaggtcgg
     6301 caacgagcac gtcgatgagt tgctcgactg gtggctggag cagccacttc aggtcggttt
     6361 cctgccgacc ccggtggccg agcaggcctt cagacgctcg cgccagcacc cgacgctgcg
     6421 cacgctgctg atcggtggcg accgcttgcg ccagttcgac agcgaccctg gcttcgccgt
     6481 tatcaacaac tacggcccga ctgaaaccac cgtggtggcg acctctggtg ccatgcagcc
     6541 gggcgggccg ttgcatatcg gcggcccgat cgccaacact cgcgtgtatg tactggacga
     6601 gcagttgcag ccggtgccgg tgggtgtcat aggcgagttg tacatcggtg gcgcgggggt
     6661 tgcgcgtggc tatctgaatc gtccgcaaat gaccgaagag cgttttatcg ccgacccgtt
     6721 cagtgccgca actcaggcgc gcctgtatcg cagcggcgat ctggtgcgct ggaatgccga
     6781 tggcagcctc gactacctgg gacgcaacga cgaccaagta aaaattcgcg gcatgcgcat
     6841 cgagctgggc gaaatcgagt cggttctggc cagtcaggct gaggtgcagg acgctgtggt
     6901 gctggtgcgc ggtgaacgtt tgctggcctg gttcaccgaa aatgctcctg tcgaacccga
     6961 agtgctgcgc gaagcgttgc gtgcacgtct tcccgcgcac atggtgccgc tggccttcac
     7021 acgcctggac gcgttgccgc tgaccagcca tggcaagctt gaccgtcgtg ccttgccgga
     7081 cccggagctg gaagcgctga ccagtcaggc ctacgcggca cccgtgggtg caactgaaac
     7141 cctcatggct gatctctggg cacacgtgct tggcctggaa aaagtcggtc gccatgacaa
     7201 cttctttgag ctgggcggcc actcgctgct ggcggtcagt ctggtcgagc gtctgcgcaa
     7261 tgccgggctc agcgtcgatg tacgcgtcct gctcggccag ccgaccgtcg ccgcgctggc
     7321 tgcatcggtg ggcaaagggc gtgaaatccc gacgccgctc aatcgcgttc cggccggttg
     7381 tacacacatc acgccggacc tgctgagcct ttcacagctc gaccagacga ccatcgagcg
     7441 cattgtcgcc acggtgcctg gcggagcggc caatgtgcag gaaatctacc cgctggcgcc
     7501 cctgcaggaa ggcattctct atcaccacct gactgccgag cagggcgacc cgtacttgct
     7561 gcaattgcgc atgaacgtcg acagcccgga gcgtctggag gcggtggccg ctgccttgcg
     7621 caaggtcatc gcgcggcacg acagtctgcg cacggcgatc gtctgggaag gcctggaaac
     7681 gccgcaacag gtggtctggc gccaggcgga tctgcttgtc gagcgggtga cactggcgca
     7741 aatcgacacc ccggcgggcg cggcgcgcat ggacttgagc tgtgcgccgc tgatcaggct
     7801 ggcctactgc ccggacgcgg aaggcccagg cctgtcggca acgctgcgtt tccatcacat
     7861 tgtggtggac gccacggcgc tcgaagtcat gcgtgaggaa atgctcgccc atctgcgcgg
     7921 cgagccgggc ccgactcagc ccgccgtgcc gtatcgcaac tatgtggccc aggcacgtct
     7981 gggtgtcagc gaagcggaac atgaggcgta tttccgcgag caactgggcg atatcgacga
     8041 gccgacgttg ccattcgatc tgcgcgatgt gcagggtgac ggcagctgca tcgaggaagc
     8101 ccagcaggtg ctgcccgatg cgttgctaca gcgcctgcgc agtcaggcgc ggcaactggg
     8161 tgtcagcgtc gccagcctgt tgcatctggc gtgggcgcgg gttctgggcg cggccaccgg
     8221 caatgaccgc gtggtattcg gcactgtgct gctaggtcgt ttgcagggcg gtgcgggtgc
     8281 cgaccgtggt atgggcatgt tcatcaatac gctgccgttg cggatcgatc tgggcaacct
     8341 cagcgtgcgc gacggcgcac gcgccacgca tgcacgactg gcggcactgc ttggccatga
     8401 gcacgcatcc ctggctcagg cacagcgctg gagcggggtg gcagcgccat tgccgttgtt
     8461 cagtgcaatt ctcaactatc gacacgccgc aggccaggcg cgccaggatg cgcagctcga
     8521 tgcatggcaa gggctggaga ttctgaccag cgagaagcac accaactacc cgttgagcct
     8581 caacgtcgac gatctgggcg acagcctgcg cctgagcgtt accgtgccac cccgggtagg
     8641 ggcgcaacgt atctgtgctt atgtgcagca gacgctgaca gccatgttgg atgcccttga
     8701 aggccagccg gatctgccgg tgcagcatct gtcggtactc ggcgctgaag agcggcagcg
     8761 ctcgctggtc gaattcaacg ccacggcgat ccatcacgat cttcagcaaa ccctgcacgg
     8821 gctgttcgaa gcacaggcgg tgcgtacgcc gcaggcgata gccctgcgcg cggggcgtgc
     8881 acaattgagc tatcgccagc tcaacgaaca ggccaactgc ctggcgcatc acctgatcga
     8941 tctgggcgtg cggcctgatc aacgggttgc gatctgtgtc gagcgcggcc tgtcgatggt
     9001 gatcggtctg ctggcgatcc tcaaggccgg tggtgcatac gtacccctgg atccgagcta
     9061 cccgcgcgag cgtttgcagt acatggtcaa ggacagcacg ccggtcgcct tgctggtaca
     9121 ggccggcacc cgcgatctgc tcgacgacga gcacgccctg cggatcgatc tggacagcgt
     9181 gacctgggac gctcagcgtg atcagaatcc gcgcgttccc ggcctgacgg cggagcatct
     9241 ggcttatgtg atttatacct cgggctccac cggtacgccg aaaggggtga tggtcgagca
     9301 ccgtaacgtc agcaacctgg tgcaatggag ctcgaggttg tgcccaccga cctcgggcac
     9361 tgtcatgctg caaaagaccc cgatcagctt cgacgcctcg gtctgggaga ttttctggcc
     9421 cctgagcagc ggtattgcgc tggtgctggc gcgtcctgac ggccagcgcg atcctgccta
     9481 cctggcgcaa gtgattcagg agcgccaggt cagcgtggtg cagttcgttc ctgcactgtt
     9541 gcagcagttc ctcgatctgc cgcagagcag cgcgtgcagc agcctgaccg acattgtctg
     9601 cgggggcggc gagctgaccg tggagatggc cgcgcagcta cgcaaacgtt tgccagaggt
     9661 acgcctgcac aacgtgtacg gcccgaccga aaccaccgtc gattgcagcg tgtggacact
     9721 gcaagccgac gaagccgtac cggacactgc cttgcctatc gggcgtccga tcagcaacac
     9781 gcggctttat gtgctcgatg cccatgacca gcccgtaccg cagggggtta tcggccagct
     9841 gcatatcggc ggtgccgggg tgacgcgtgg ctacctgaac ctgccaaaga ccgatgccga
     9901 acgttttatc gacagccctt tcgtagcagg cgaccgcctg taccgcagtg gcgatctggt
     9961 acgccagcgg gcagacggca acctcgagtt ccttggccgc aatgacgatc aggtgaagat
    10021 ccacgggttg cgtatcgaac cgggcgacat tcaggcctgc ctgatcagcc atccgggtat
    10081 cgaacaggcg gtcgtgctgg tgcgcgacga gcaaccaggc gggcagcggc tggtggccta
    10141 ttacaccggc acacagctgt cggtcgagac attgcgtgag gtgctgcgtg cgcagttgcc
    10201 ggattacatg gtgcccgcac tgttcgtgca tctggatgaa atgcccctga gccccaacgg
    10261 caagctggac cgcaaggcgc tgcctgcgcc cgggcaggat gcgctcctga cccgccctta
    10321 tgaagcaccg caaggcgaaa ccgaagcctt gctggccagg ctctggagcg aactgctcgg
    10381 ggtcgggcag gtcggccgtc acgacaactt tttcgaactg ggcggtcatt cgctgctggc
    10441 ggtgagcctg actgcgcgcc tgcgccagga aggcatcgag gccgatgtcc gggcgctttt
    10501 cgaacaacct acgctggcgg gctacgcagc catcacagag aacatggaga ttaccctgtg
    10561 a
//
