LOCUS       BGC0002528             12492 bp    DNA     linear   BCT 11-DEC-2013
DEFINITION  Azotobacter vinelandii CA, complete genome.
ACCESSION   BGC0002528
VERSION     BGC0002528
KEYWORDS    .
SOURCE      Azotobacter vinelandii CA
  ORGANISM  Azotobacter vinelandii CA
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Azotobacter.
COMMENT     Source bacteria available from the submitter.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:55:27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2108872
            Orig. end    :: 2121364
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1299)
                     /NRPS_PKS="Domain: Condensation_Starter (5-300). E-value:
                     1.9e-80. Score: 262.2. Matches aSDomain:
                     nrpspksdomains_AvCA_21160_Condensation_Starter.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: VibH_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     316.7; E-value: 5.1e-96)"
                     /gene_kind="biosynthetic"
                     /locus_tag="AvCA_21160"
                     /product="Condensation domain protein"
                     /protein_id="AGK16779.1"
                     /sec_met_domain="Condensation (E-value: 2.3e-35, bitscore:
                     111.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="VibH_like (E-value: 2.3e-157, bitscore:
                     513.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNATPSRLPATTAQFSIWVAQQAVPDSPAYLTAETIELLGAVDRA
                     ALSDTVVEVLNNCHSLHMRFVHEEGRLWQLPQPPACPPLALHDFRREPDPAAAAQAWID
                     RELSRTLDPSRDVLYRSALLQLGDQHHLWYLQAHHVTLDGYAYGLVCQTIAERYSARVR
                     QSELPPLPDWSMARVVQAEQDYRAKGLFERDKQFWLQQLRDVPAPATIAEAAEFPEQVI
                     RSETRLQRDQVAMLQEAARACGQDWGNWVLAAIGLWLGRQSGQQALTFALPAMNRLGTP
                     ALGVPCMAMNIVPLSLRIDPAGSMASHAQQIAGEMRRIRPHLYYRYGWMRMDLGLMEAQ
                     KHLFNQAVNLMPFDRKAAFAGLDSRIRPITAGPVKDLNVTLAVLDAEWRLCVEANPHAY
                     SSDRLEQLHGDLLDWLQRLARHAPEAPLQALWQ"
     subregion       1..12492
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="NRPS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12492
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1299)
                     /locus_tag="AvCA_21160"
     CDS_motif       complement(250..360)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21160_0006"
                     /evalue="6.20E-09"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="AvCA_21160"
                     /protein_end="350"
                     /protein_start="313"
                     /score="28.4"
                     /tool="antismash"
                     /translation="GEMRRIRPHLYYRYGWMRMDLGLMEAQKHLFNQAVNL"
     aSDomain        complement(400..1284)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21160_Condensation_Starter.
                     1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="1.90E-80"
                     /label="AvCA_21160_Condensation_Starter.1"
                     /locus_tag="AvCA_21160"
                     /protein_end="300"
                     /protein_start="5"
                     /score="262.2"
                     /tool="antismash"
                     /translation="SRLPATTAQFSIWVAQQAVPDSPAYLTAETIELLGAVDRAALSDT
                     VVEVLNNCHSLHMRFVHEEGRLWQLPQPPACPPLALHDFRREPDPAAAAQAWIDRELSR
                     TLDPSRDVLYRSALLQLGDQHHLWYLQAHHVTLDGYAYGLVCQTIAERYSARVRQSELP
                     PLPDWSMARVVQAEQDYRAKGLFERDKQFWLQQLRDVPAPATIAEAAEFPEQVIRSETR
                     LQRDQVAMLQEAARACGQDWGNWVLAAIGLWLGRQSGQQALTFALPAMNRLGTPALGVP
                     CMAMNIVPLSLRID"
     CDS_motif       complement(415..495)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21160_0005"
                     /evalue="1.40E-08"
                     /label="C5_starter_265-294"
                     /locus_tag="AvCA_21160"
                     /protein_end="295"
                     /protein_start="268"
                     /score="27.1"
                     /tool="antismash"
                     /translation="TFALPAMNRLGTPALGVPCMAMNIVPL"
     CDS_motif       complement(826..891)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21160_0004"
                     /evalue="1.40E-07"
                     /label="C3_starter_134-155"
                     /locus_tag="AvCA_21160"
                     /protein_end="158"
                     /protein_start="136"
                     /score="24.4"
                     /tool="antismash"
                     /translation="AHHVTLDGYAYGLVCQTIAERY"
     CDS_motif       complement(892..915)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21160_0003"
                     /evalue="1.50E+01"
                     /label="C1_starter_004-017"
                     /locus_tag="AvCA_21160"
                     /protein_end="136"
                     /protein_start="128"
                     /score="-0.2"
                     /tool="antismash"
                     /translation="QHHLWYLQ"
     CDS_motif       complement(1102..1218)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21160_0002"
                     /evalue="1.60E-08"
                     /label="C2_starter_024-063"
                     /locus_tag="AvCA_21160"
                     /protein_end="66"
                     /protein_start="27"
                     /score="27.2"
                     /tool="antismash"
                     /translation="PAYLTAETIELLGAVDRAALSDTVVEVLNNCHSLHMRFV"
     CDS_motif       complement(1237..1275)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21160_0001"
                     /evalue="6.80E-02"
                     /label="C1_starter_004-017"
                     /locus_tag="AvCA_21160"
                     /protein_end="21"
                     /protein_start="8"
                     /score="6.6"
                     /tool="antismash"
                     /translation="PATTAQFSIWVAQ"
     gene            complement(1353..2450)
                     /locus_tag="AvCA_21170"
     CDS             complement(1353..2450)
                     /codon_start=1
                     /locus_tag="AvCA_21170"
                     /product="esterase"
                     /protein_id="AGK16778.1"
                     /transl_table=11
                     /translation="MPVEKRRAFSTGTAENRRIGRDRAVTNPRRELILPTHPSRPSARL
                     LTGFGALALALGLMAGMPAHAETPTAEDWAGLPADWRPAGLSRTLGFEMTSKNTGQRYR
                     ILVGLPHRAPLPSGYPTLWMLDGLASYPIAEYVRPRPVSAGQSAQWVAKKLKDTPAGLV
                     IGVGYASGDPFDVNARALDYTPVPAGRTGDQFSSEHGGAAAFLKFLTEELRPLIARYFP
                     MNPRQHSLFGFSYGGLFAVHTLLTEPGHFQRYWAASPSLWFGERQLLRQLPERLETLRF
                     EQPTRLMITVGLDEQYPASFPSEEQKRHMQERAIVDLVRDAARRLEAARLPNLQVTARV
                     VPEQDHLDMLMHGARRVVEKFAFTP"
     gene            complement(2473..3270)
                     /gene="entA"
                     /locus_tag="AvCA_21180"
     CDS             complement(2473..3270)
                     /NRPS_PKS="Domain: PKS_KR (13-169). E-value: 3.2e-16.
                     Score: 51.6. Matches aSDomain:
                     nrpspksdomains_AvCA_21180_PKS_KR.1"
                     /codon_start=1
                     /gene="entA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: EntA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     247.4; E-value: 2.5e-75)"
                     /gene_kind="biosynthetic"
                     /locus_tag="AvCA_21180"
                     /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase,
                     short-chain dehydrogenase/reductase"
                     /protein_id="AGK13423.1"
                     /sec_met_domain="EntA (E-value: 1.6e-111, bitscore: 361.2,
                     seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.9e-35, bitscore:
                     111.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTTTKTSEFAGQVALVTGAAAGIGAAVATALGRREARLVLLDRD
                     AGALQAQAESLRAIGCEVLACTLDLRDAQALEAAVAEGERVLGPIDLLANVAGVLFSGG
                     TLELTDQAWEDTFAINTTAVFRLCRAVARGMLERKRGCIVTVASNAAHAPRLGMAAYAA
                     SKAATVHYMRCLALELAPHGIRCNTVSPGSTDTPMQRAFAPTPEHVQNVLSGSLERYRL
                     GIPLGRIATPEDIADAVCFLASDQARHITMHDLVVDGGATLGA"
     aSDomain        complement(2764..3231)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21180_PKS_KR.1"
                     /evalue="3.20E-16"
                     /label="AvCA_21180_PKS_KR.1"
                     /locus_tag="AvCA_21180"
                     /protein_end="169"
                     /protein_start="13"
                     /score="51.6"
                     /tool="antismash"
                     /translation="VALVTGAAAGIGAAVATALGRREARLVLLDRDAGALQAQAESLRA
                     IGCEVLACTLDLRDAQALEAAVAEGERVLGPIDLLANVAGVLFSGGTLELTDQAWEDTF
                     AINTTAVFRLCRAVARGMLERKRGCIVTVASNAAHAPRLGMAAYAASKAATV"
     CDS_motif       complement(2839..2892)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21180_0002"
                     /evalue="2.40E-01"
                     /label="PKSI-KR_m1"
                     /locus_tag="AvCA_21180"
                     /protein_end="144"
                     /protein_start="126"
                     /score="4.2"
                     /tool="antismash"
                     /translation="LCRAVARGMLERKRGCIV"
     CDS_motif       complement(3139..3225)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21180_0001"
                     /evalue="1.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AvCA_21180"
                     /protein_end="44"
                     /protein_start="15"
                     /score="14.8"
                     /tool="antismash"
                     /translation="LVTGAAAGIGAAVATALGRREARLVLLDR"
     gene            complement(3280..7272)
                     /gene="entF"
                     /locus_tag="AvCA_21190"
     CDS             complement(3280..7272)
                     /NRPS_PKS="Domain: Condensation_Starter (16-312). E-value:
                     2.6e-79. Score: 258.5. Matches aSDomain:
                     nrpspksdomains_AvCA_21190_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (471-872). E-value:
                     8.7e-101. Score: 329.3. Matches aSDomain:
                     nrpspksdomains_AvCA_21190_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (995-1060). E-value: 3.9e-18. Score:
                     57.3. Matches aSDomain: nrpspksdomains_AvCA_21190_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1086-1308). E-value:
                     4.5e-28. Score: 91.1. Matches aSDomain:
                     nrpspksdomains_AvCA_21190_Thioesterase.1"
                     /codon_start=1
                     /gene="entF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     302.5; E-value: 1e-91)"
                     /gene_kind="biosynthetic"
                     /locus_tag="AvCA_21190"
                     /product="enterochelin sythetase component F
                     (Serine-activating enzyme) (Seryl-AMP ligase)"
                     /protein_id="AGK13426.1"
                     /sec_met_domain="Condensation (E-value: 2.8e-40, bitscore:
                     127.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 3.9e-109, bitscore:
                     354.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.8e-15, bitscore:
                     46.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPCSAETGVAGEPTLARLPLSAAQLGIWLGQRLDPLSPAYWTAEA
                     VELRGALDEAAFERALEQAVEASEALHMRFEAEGDDIWQRPDRTAWTLRRIDLSATESS
                     AGQAWDRAWQWIRNDLRSLPDLANGPLFGMALLRLAADHHLWLLRVHHIALDGYGYALL
                     IRRVAELYEAERQGTAMTRLPSAAGLAEVVDEARAYQRQAQRNRDFWVARLLDAPPPVT
                     LAPGAALARDVRRRRALLPARALADWQRAAGACGVDWAAWLLAAIGGWLARRTAAPEVC
                     LGLPVMTRLGSRALNVPCMAMNIVPLRLPVDIDRGMQALAADVAAEMRASRPHQRYRYE
                     WLRQDLAQARRQVGRGQGLFGPVVNLMPFERPDTFGDLQARQHPVSAGPVEDLSISVVP
                     GAEGVRLDLEANPDAYGDELLATLHEELIAALDSLQRAPATTPLRQLLREPPLARLAGE
                     PLPPVVDVLTALGNHAARTPKAPALEQDGVRLNYAELLQAVSALAGVLVAQGVTTESRV
                     AVLLPRSPDTVVALLAVLWAGAGYVPLDPESPEARIAMVLEDSAPTLVITCRAQRERVP
                     AGQPVLLLDEPRPTAVVLGQPRPVAPDALAYIIYTSGTTGRPNGVMIGRDALAHFVAGA
                     RQRYAMRASDRVLQFAPLHFDASVEEIFLTLASGACLVLRNDEMLESVPRFLDACAVRD
                     ITVLDLPTAFWHELAYGLGAQTPLPPHLRLVIIGGEAALAERVQRWQAQAPAQAVLLNT
                     YGPTETTVICTTATLSGPDALDWQGETLPIGHPLPGVEVAVVDANLRPVQRGERGELCV
                     LGGSLARGYFGREERTAARFVVLPGLPGAPRAYRTGDLVRMRDDGALVYLGRLDDEFKI
                     SGYRIDPTEIETALLGYPHTPGIREAAVLGQVLPGGVKRLVAFLALEEAQAELPPVAAL
                     RAHLARSLPAPAVPGTYLQLAKLPRNANNKIDRKVLKELAERQAAGQTAVPGADEARDN
                     LSVLIRQVSRVWREVLGLSDIVPNSDFFALGGESLQAIQVANRLGMLLQREVPVSSLFR
                     YPTVGALAEALDLPVGHEPPARQDPFAPLLCLQPGEGPALFCIYPSEGLSWCYMGLAAH
                     LPHTPIYGLQARGITGAPPDDIDALLDDCLALMRGAQPHGPYRMIGWSSGGGIAHALAA
                     RLQEAGETVDLLAMMDAYPADIWAGKPPPTERDALITLLDVIGDAPFGPDGTPLSEAQM
                     RERLARPGSSLAAAGAADAGVLSRLADISVHSMLLYRTLRHPVFEGDVLYFFATQRKPD
                     MPDWQLWRPYVAGRLDKVDIASTHNGMSRPLPLAQIGRALAARLYP"
     aSDomain        complement(3349..4014)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21190_Thioesterase.1"
                     /evalue="4.50E-28"
                     /label="AvCA_21190_Thioesterase.1"
                     /locus_tag="AvCA_21190"
                     /protein_end="1308"
                     /protein_start="1086"
                     /score="91.1"
                     /tool="antismash"
                     /translation="ALFCIYPSEGLSWCYMGLAAHLPHTPIYGLQARGITGAPPDDIDA
                     LLDDCLALMRGAQPHGPYRMIGWSSGGGIAHALAARLQEAGETVDLLAMMDAYPADIWA
                     GKPPPTERDALITLLDVIGDAPFGPDGTPLSEAQMRERLARPGSSLAAAGAADAGVLSR
                     LADISVHSMLLYRTLRHPVFEGDVLYFFATQRKPDMPDWQLWRPYVAGRLDKVDIASTH
                     "
     aSModule        complement(3349..7224)
                     /complete
                     /domains="nrpspksdomains_AvCA_21190_Condensation_Starter.1"
                     /domains="nrpspksdomains_AvCA_21190_AMP-binding.1"
                     /domains="nrpspksdomains_AvCA_21190_PCP.1"
                     /domains="nrpspksdomains_AvCA_21190_Thioesterase.1"
                     /final_module
                     /locus_tags="AvCA_21190"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(3769..3843)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0011"
                     /evalue="2.50E-11"
                     /label="NRPS-te1"
                     /locus_tag="AvCA_21190"
                     /protein_end="1168"
                     /protein_start="1143"
                     /score="35.9"
                     /tool="antismash"
                     /translation="QPHGPYRMIGWSSGGGIAHALAARL"
     aSDomain        complement(4093..4287)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21190_PCP.1"
                     /evalue="3.90E-18"
                     /label="AvCA_21190_PCP.1"
                     /locus_tag="AvCA_21190"
                     /protein_end="1060"
                     /protein_start="995"
                     /score="57.3"
                     /tool="antismash"
                     /translation="QVSRVWREVLGLSDIVPNSDFFALGGESLQAIQVANRLGMLLQRE
                     VPVSSLFRYPTVGALAEALD"
     CDS_motif       complement(4627..4692)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0010"
                     /evalue="8.90E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="AvCA_21190"
                     /protein_end="882"
                     /protein_start="860"
                     /score="24.5"
                     /tool="antismash"
                     /translation="YLGRLDDEFKISGYRIDPTEIE"
     aSDomain        complement(4657..5859)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21190_AMP-binding.1"
                     /evalue="8.70E-101"
                     /label="AvCA_21190_AMP-binding.1"
                     /locus_tag="AvCA_21190"
                     /protein_end="872"
                     /protein_start="471"
                     /score="329.3"
                     /tool="antismash"
                     /translation="NHAARTPKAPALEQDGVRLNYAELLQAVSALAGVLVAQGVTTESR
                     VAVLLPRSPDTVVALLAVLWAGAGYVPLDPESPEARIAMVLEDSAPTLVITCRAQRERV
                     PAGQPVLLLDEPRPTAVVLGQPRPVAPDALAYIIYTSGTTGRPNGVMIGRDALAHFVAG
                     ARQRYAMRASDRVLQFAPLHFDASVEEIFLTLASGACLVLRNDEMLESVPRFLDACAVR
                     DITVLDLPTAFWHELAYGLGAQTPLPPHLRLVIIGGEAALAERVQRWQAQAPAQAVLLN
                     TYGPTETTVICTTATLSGPDALDWQGETLPIGHPLPGVEVAVVDANLRPVQRGERGELC
                     VLGGSLARGYFGREERTAARFVVLPGLPGAPRAYRTGDLVRMRDDGALVYLGRLDDEFK
                     IS"
     CDS_motif       complement(4777..4860)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0009"
                     /evalue="8.70E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="AvCA_21190"
                     /protein_end="832"
                     /protein_start="804"
                     /score="34.1"
                     /tool="antismash"
                     /translation="GERGELCVLGGSLARGYFGREERTAARF"
     CDS_motif       complement(5404..5457)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0008"
                     /evalue="2.70E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="AvCA_21190"
                     /protein_end="623"
                     /protein_start="605"
                     /score="26.0"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGRPNGVMI"
     CDS_motif       complement(5638..5679)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0007"
                     /evalue="1.50E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="AvCA_21190"
                     /protein_end="545"
                     /protein_start="531"
                     /score="15.1"
                     /tool="antismash"
                     /translation="LAVLWAGAGYVPLD"
     CDS_motif       complement(6175..6300)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0006"
                     /evalue="6.20E-15"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="AvCA_21190"
                     /protein_end="366"
                     /protein_start="324"
                     /score="47.6"
                     /tool="antismash"
                     /translation="AAEMRASRPHQRYRYEWLRQDLAQARRQVGRGQGLFGPVVNL"
     aSDomain        complement(6337..7224)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21190_Condensation_Starter.
                     1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="2.60E-79"
                     /label="AvCA_21190_Condensation_Starter.1"
                     /locus_tag="AvCA_21190"
                     /protein_end="312"
                     /protein_start="16"
                     /score="258.5"
                     /tool="antismash"
                     /translation="RLPLSAAQLGIWLGQRLDPLSPAYWTAEAVELRGALDEAAFERAL
                     EQAVEASEALHMRFEAEGDDIWQRPDRTAWTLRRIDLSATESSAGQAWDRAWQWIRNDL
                     RSLPDLANGPLFGMALLRLAADHHLWLLRVHHIALDGYGYALLIRRVAELYEAERQGTA
                     MTRLPSAAGLAEVVDEARAYQRQAQRNRDFWVARLLDAPPPVTLAPGAALARDVRRRRA
                     LLPARALADWQRAAGACGVDWAAWLLAAIGGWLARRTAAPEVCLGLPVMTRLGSRALNV
                     PCMAMNIVPLRLPVD"
     CDS_motif       complement(6349..6438)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0005"
                     /evalue="1.80E-13"
                     /label="C5_starter_265-294"
                     /locus_tag="AvCA_21190"
                     /protein_end="308"
                     /protein_start="278"
                     /score="42.7"
                     /tool="antismash"
                     /translation="EVCLGLPVMTRLGSRALNVPCMAMNIVPLR"
     CDS_motif       complement(6760..6825)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0004"
                     /evalue="1.50E-11"
                     /label="C3_starter_134-155"
                     /locus_tag="AvCA_21190"
                     /protein_end="171"
                     /protein_start="149"
                     /score="36.9"
                     /tool="antismash"
                     /translation="VHHIALDGYGYALLIRRVAELY"
     CDS_motif       complement(6871..6930)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0003"
                     /evalue="1.10E+01"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="AvCA_21190"
                     /protein_end="134"
                     /protein_start="114"
                     /score="-1.2"
                     /tool="antismash"
                     /translation="WIRNDLRSLPDLANGPLFGM"
     CDS_motif       complement(7045..7161)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0002"
                     /evalue="3.50E-15"
                     /label="C2_starter_024-063"
                     /locus_tag="AvCA_21190"
                     /protein_end="76"
                     /protein_start="37"
                     /score="48.5"
                     /tool="antismash"
                     /translation="PAYWTAEAVELRGALDEAAFERALEQAVEASEALHMRFE"
     CDS_motif       complement(7180..7221)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AvCA_21190_0001"
                     /evalue="1.60E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="AvCA_21190"
                     /protein_end="31"
                     /protein_start="17"
                     /score="11.3"
                     /tool="antismash"
                     /translation="LPLSAAQLGIWLGQ"
     gene            complement(7274..8110)
                     /gene="entB"
                     /locus_tag="AvCA_21200"
     CDS             complement(7274..8110)
                     /NRPS_PKS="Domain: PP-binding (209-268). E-value: 1.8e-10.
                     Score: 33.1. Matches aSDomain:
                     nrpspksdomains_AvCA_21200_PP-binding.1"
                     /codon_start=1
                     /gene="entB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 351.1; E-value: 5e-107)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AvCA_21200"
                     /product="Isochorismatase (2,3 dihydro-2,3
                     dihydroxybenzoate synthase)"
                     /protein_id="AGK13424.1"
                     /sec_met_domain="PP-binding (E-value: 2.9e-11, bitscore:
                     33.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAAETFPSGRVDWQADPKRVALLVHDMQEYFIDFYDRSAAPIPQ
                     LVANIRRLIDACDAAGVPVYYTAQPAVQPAGDRALLNEFWGPGLPAKPEGAPVIAALAP
                     RENHVVLDKWRYSAFIRSDLRERLQAAGRDQLMVCGIYAHIGCQTTCVDAFMRDVQPIM
                     VGDALADFSPERHRQALDYVVACAGVVRDTDQLIAALAGGLPASIEALHQEVAQMLGMP
                     ASDFSVEDNLLDVGLDSIRLMSLLEGWKRAGAQVSFVQVAEQPTLAHWWSLLSEGR"
     aSDomain        complement(7307..7483)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21200_PP-binding.1"
                     /evalue="1.80E-10"
                     /label="AvCA_21200_PP-binding.1"
                     /locus_tag="AvCA_21200"
                     /protein_end="268"
                     /protein_start="209"
                     /score="33.1"
                     /tool="antismash"
                     /translation="ALHQEVAQMLGMPASDFSVEDNLLDVGLDSIRLMSLLEGWKRAGA
                     QVSFVQVAEQPTLA"
     gene            complement(8203..9849)
                     /gene="entE"
                     /locus_tag="AvCA_21210"
     CDS             complement(8203..9849)
                     /NRPS_PKS="Domain: AMP-binding (44-446). E-value: 1.9e-87.
                     Score: 285.4. Matches aSDomain:
                     nrpspksdomains_AvCA_21210_AMP-binding.1"
                     /codon_start=1
                     /gene="entE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     492.3; E-value: 2.2e-149)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AvCA_21210"
                     /product="enterobactin synthetase component E
                     (2,3-dihydroxybenzoate-AMP ligase)"
                     /protein_id="AGK13425.1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-98, bitscore:
                     319.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTPTSSSAEGADFTPWPAEFAARYRAAGYWRGEPLDSLLRAG
                     ADRHAGRTALVCGERRWTYAELDARVDRVAAGLVGQGIAAGDRVVVQLPNIAEFVMVIF
                     ALLRLGALPVFALPAHRRAEIGYFCAFAEAKGLVIRDRHAGFDYRQMARDIRDEAATLS
                     TVVVVGEAEEFIPFERLDAEPLPLPEPKADTLAFLQLSGGSTGRPKMIPRTHDDYFYSV
                     RASAEICGLGPDTVFLCALPAAHNFAMSSPGILGVLYAGGSVVLAPDPSPDTCFALIAR
                     ERVDMTALVPSVALAWMEAAPARQAELASLKVLQVGGSRLSDEAAQRVDSLLGCKLQQV
                     FGMAEGLVNYTRFDDPQELIVGTQGRPISPDDEVRIVDDEDRDVPPGETGHLITRGPYT
                     IRGYFRADVHNARSFTRDGFYRTGDVARRLPSGHLIVEGRDKDQINRGGDKVAAEEVEN
                     HLLAHPAVLDVAVVAMPDAFLGERTCAFIVPRGEAPRPLEINRFMRERGVAGYKVPDRI
                     EFVDQLPKTGVGKIDKRALRERIAARLQATA"
     aSDomain        complement(8512..9717)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AvCA_21210_AMP-binding.1"
                     /evalue="1.90E-87"
                     /label="AvCA_21210_AMP-binding.1"
                     /locus_tag="AvCA_21210"
                     /protein_end="446"
                     /protein_start="44"
                     /score="285.4"
                     /tool="antismash"
                     /translation="GADRHAGRTALVCGERRWTYAELDARVDRVAAGLVGQGIAAGDRV
                     VVQLPNIAEFVMVIFALLRLGALPVFALPAHRRAEIGYFCAFAEAKGLVIRDRHAGFDY
                     RQMARDIRDEAATLSTVVVVGEAEEFIPFERLDAEPLPLPEPKADTLAFLQLSGGSTGR
                     PKMIPRTHDDYFYSVRASAEICGLGPDTVFLCALPAAHNFAMSSPGILGVLYAGGSVVL
                     APDPSPDTCFALIARERVDMTALVPSVALAWMEAAPARQAELASLKVLQVGGSRLSDEA
                     AQRVDSLLGCKLQQVFGMAEGLVNYTRFDDPQELIVGTQGRPISPDDEVRIVDDEDRDV
                     PPGETGHLITRGPYTIRGYFRADVHNARSFTRDGFYRTGDVARRLPSGHLIVEGRDKDQ
                     INR"
     gene            complement(9846..11057)
                     /gene="csbC"
                     /locus_tag="AvCA_21220"
     CDS             complement(9846..11057)
                     /codon_start=1
                     /gene="csbC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: EntC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 368.7; E-value:
                     9.2e-112)"
                     /gene_kind="biosynthetic"
                     /locus_tag="AvCA_21220"
                     /product="Isochorismate synthase"
                     /protein_id="AGK13349.1"
                     /sec_met_domain="EntC (E-value: 1.5e-146, bitscore: 477.9,
                     seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFVQQTQLAQSFSEPCGPQVLFTHYHRDACMFASPGQTLLAHGV
                     AATLPLVMSGSPAALAGHAAAFLRQASEAGHAGWLIGAIPFLPGAAAHLFIPEHVELAG
                     GGRAALVGGPRPVRTVAARSEPAEAVYEQNVSRALERIADGKLQKVVLSRSLHIQAELD
                     QAELLQTLASRNPLGYTYAIPLPTANGERRSLIGASPELLLARHGNRVISNPLAGSIPH
                     SSDPAEDRQRAENLLRSPKDLHEHALVVEAVAEALRPYCTDLLVPEAPSLLSTPTMWHL
                     STEVTGTLRDPATTSLELALALHPTPAVGGYPTAEAREFIQAFEGFDRGFFTGLVGWCN
                     AQGDGEWAVTIRCAEVGEQSSTLYAGAGIVAGSEPALELAETAAKLRTMLGAMGLALAE
                     ENRA"
     gene            11269..12492
                     /gene="csbX"
                     /locus_tag="AvCA_21230"
     CDS             11269..12492
                     /codon_start=1
                     /gene="csbX"
                     /gene_functions="transport (smcogs) SMCOG1184:major
                     facilitator transporter (Score: 292.2; E-value: 7.5e-89)"
                     /gene_kind="transport"
                     /locus_tag="AvCA_21230"
                     /product="catecholate siderophore efflux pump, MFS_1
                     family"
                     /protein_id="AGK13350.1"
                     /transl_table=11
                     /translation="MNPDQSLQSEARTKPFAAISPKVLIALIASLQFTYILDFMLVLPL
                     GPDLAKGLNFHGNQVAWLTASYTFASLLSGLFTVPRLDRFDRRKALLWSLVGLALASLA
                     CTLAHDLPSLLLGRAVAGLCAAPAIATGMAILIDQTPPPQRGTAIAKVMTGFSIATIAG
                     IPLALELADHFGWQAPFVLVAVLVVLVAFAVAHLLPPLTAHLQGPAGKPSLAMLSRPGV
                     RLATLLQGLNQFSAFLVIPSFSAFYLLNLDYPRQQLGTLYLVGGLVALGAMQLAGRLGD
                     RHGHWLPVGVASACFAVGLLPFFGLSALPLMLSFVLFMAGNAARTVCLAAAISHVPAPP
                     ERAGFMALQKMTQDFSVALAAGAAALVLGGGDGPLTHTGLLATLAIVGAGLVLWVLERL
                     RRNLQPPA"
ORIGIN
        1 ttattgccac agcgcctgca ggggcgcctc cggggcgtgc ctggccagcc gttgcagcca
       61 gtccagcagg tccccgtgca attgctccag tcggtcgctg gagtaggcgt ggggattggc
      121 ttcgacgcag agccgccact cggcgtccag taccgccagg gtgacgttga ggtccttgac
      181 cggtccggcg gtgatgggcc tgatgcggct gtccagcccg gcgaaggcgg ccttgcggtc
      241 gaagggcatg aggttgaccg cctggttgaa caggtgcttc tgcgcctcca tcaggcccag
      301 gtccatgcgc atccagccgt agcggtaata caggtgcggg cggatgcggc gcatctcgcc
      361 ggcgatctgc tgcgcatggc tggccatcga gccggccggg tcgatgcgca ggctcagcgg
      421 cactatgttc atcgccatgc agggtacgcc cagcgccggg gtgcccagcc ggttcatcgc
      481 cggcagggcg aaggtcagcg cctgctggcc ggattgcctg cccagccaga gtccgatggc
      541 cgccagcacc cagttgcccc agtcctgccc gcaggcgcgg gccgcctcct gcagcatggc
      601 cacctggtcg cgttgcagcc gggtttcgct gcgaatgacc tgctcgggaa actccgccgc
      661 ctcggcgatg gtggccggtg ccgggacatc ccgcagctgc tgcagccaga actgcttgtc
      721 gcgctcgaac agtcccttgg cccggtaatc ctgctcggcc tgcaccaccc gcgccatcga
      781 ccagtccggc aggggcggca gctcgctttg ccggaccctg gcgctgtagc gctcggcgat
      841 ggtctggcag accaggccgt aggcgtagcc gtccagcgtc acatggtggg cctgcaggta
      901 ccagagatgg tgctggtcgc ccagttgcag cagggcgctc cggtagagca cgtcgcggct
      961 cgggtcgagg gtgcggctca gttcccggtc gatccaggcc tgggccgcgg cggccgggtc
     1021 gggctcgcgg cggaagtcgt gcagcgccag cggcgggcag gccggcggct gcggcaattg
     1081 ccacagccgg ccttcctcgt ggacgaagcg catgtgcagg ctgtggcagt tgttcaggac
     1141 ctcgaccacc gtgtccgaca gcgccgcgcg atcgacggcg ccgagcagct cgatggtttc
     1201 ggccgtgagg taggccggac tgtcgggtac ggcctgctgg gcgacccaga tgctgaactg
     1261 ggcggtggtg gcgggcaagc gggaaggcgt ggcgttcatg gcggatacct gcgacaaggt
     1321 actgactgaa ggagtggagg gacggggtcc ggtcagggcg tgaaggcgaa cttctcgacg
     1381 acccggcggg cgccatgcat cagcatgtcc agatggtcct gctcggggac gacgcgcgcc
     1441 gtcacctgca ggttgggcag gcgtgccgct tccagccgcc gtgcggcgtc gcgcacgaga
     1501 tcgacgatgg cgcgttcctg catgtgccgc ttctgttcct cggaaggaaa gctggccgga
     1561 tactgctcgt ccaggccaac ggtgatcatc agccgggtgg gctgttcgaa gcgcagcgtt
     1621 tccaggcgtt cgggcaactg gcgcaggagc tgtcgctcgc cgaaccagag cgaggggctg
     1681 gccgcccagt aacgctggaa atgccctggt tcggtcagca gggtgtgcac ggcgaacagc
     1741 ccgccatagg aaaacccgaa caggctgtgc tgccgtggat tcatcggaaa ataccgggcg
     1801 atcagcgggc gcagctcctc ggtcaggaac ttcaggaagg ccgccgcgcc accgtgctcg
     1861 ctggagaact ggtcgccggt ccggccggcc ggcaccggcg tgtaatccag cgcccgggca
     1921 ttgacgtcga agggatcgcc actggcgtaa ccgactccga tcaccaggcc ggccggcgta
     1981 tccttcagct ttttcgccac ccattgcgcg ctctgtccgg cggacaccgg gcggggccgg
     2041 acgtattcgg cgatcggata gctggccagt ccgtcgagca tccacagcgt gggatagccg
     2101 ctcggcagcg gcgcccggtg cggcagcccg accaggatgc ggtagcgctg gccggtgttc
     2161 ttcgaggtca tctcgaagcc gagggtgcgg gaaagcccgg ccggccgcca gtcggccggc
     2221 aggccggccc agtcttcggc ggtcggggtt tcggcgtggg ccggcatgcc ggccatgagc
     2281 cccagggcca gcgccagggc accgaacccg gtcagcagcc gggcggatgg gcgagaagga
     2341 tgcgtgggca aaatgagttc tcgtcttggg ttcgtgacag cgcggtctcg gccgatccgc
     2401 cggttttcgg cggtgccggt ggaaaacgcg cggcgctttt ccaccggcac cgcctcccgg
     2461 cgcggcctcg gctcaggcgc cgagggtggc gccgccgtcg accaccaggt cgtgcatggt
     2521 gatatgccgg gcctggtccg aggcgaggaa gcagacggca tcggcgatgt cttccggcgt
     2581 ggcgatgcgg cccagcggaa tgcccagccg gtagcgttcc agcgagccgc tcagcacgtt
     2641 ctgcacgtgt tccggggtgg gcgcgaaggc gcgctgcatc ggggtgtcgg tggagcccgg
     2701 cgacaccgtg ttgcagcgaa tgccatgggg cgccagttcc agcgccaggc agcgcatgta
     2761 atgcactgtc gccgccttgg acgcggcata ggccgccatg cccagccggg gcgcgtgggc
     2821 ggcgttggag gcgacggtga cgatgcagcc gcgcttgcgc tccagcatgc cgcgcgccac
     2881 cgcgcggcac aggcggaaca cggcggtggt gttgatggcg aaggtgtctt cccaggcctg
     2941 gtcggtcagt tccagcgtgc cgccggagaa cagcacgccg gcgacgttgg ccagcaggtc
     3001 gatcggcccc aggacccgtt cgccttcggc cacggcggct tccagcgcct gggcgtcgcg
     3061 caggtccagc gtgcaggcca gcacctcgca accgatggcc cgcaggcttt ccgcctgtgc
     3121 ctgcagcgcg ccggcgtcgc gatcgagcag caccaggcgc gcctcccgcc ggcccagcgc
     3181 cgtggcgacc gccgcgccga tgcccgccgc cgcgccggtc accagcgcga cctggccggc
     3241 gaattcgctc gtcttcgttg tcgtgtccat ccgcttctcc tatgggtaca ggcgcgccgc
     3301 cagcgcccgg ccgatctggg ccagcggcag cggacggctc atgccgttgt gtgtcgatgc
     3361 gatatccacc ttgtccagcc gcccggccac gtaggggcgc cagagctgcc agtcgggcat
     3421 gtccggcttg cgctgggtgg cgaagaaata gagcacgtcg ccctcgaata ccgggtggcg
     3481 cagggtgcgg tagagcagca tcgaatggac gctgatgtcc gccagccggg acagcacgcc
     3541 ggcatcggcc gccccggccg ccgccaggct ggagccgggc cgggccagcc gctcgcgcat
     3601 ctgcgcctcg ctcagggggg tgccgtccgg gccgaagggc gcgtcgccga tcacgtccag
     3661 cagggtgatc agcgcgtcgc gttcggtggg cggcggcttg ccggcccaga tgtcggcggg
     3721 ataggcgtcc atcatcgcca gcaggtcgac cgtctccccg gcctcctgca gacgcgcggc
     3781 cagcgcatgg gcgatgccgc cgccggagga ccagccgatc atccggtagg gaccgtgcgg
     3841 ctgcgcgccg cgcatcagcg ccaggcagtc gtccagcagg gcgtcgatgt cgtccggcgg
     3901 cgcgcccgtg ataccgcgtg cctgcaggcc gtagatcggg gtgtgtggca gatgcgcggc
     3961 cagtcccatg tagcaccagg acaggccctc gctggggtag atgcagaaca gcgccggccc
     4021 ttcccccggc tgcaggcaga gcagcggagc aaaggggtcc tggcgggccg gcggctcgtg
     4081 cccgaccggc aggtccagcg cttcggccag ggcgccgacc gtggggtagc ggaacaggct
     4141 ggagaccggc acctcgcgct gcagcagcat gcccagccgg ttggccacct ggatggcctg
     4201 cagggattcg ccgccgaggg cgaagaagtc gctgttcggg acgatgtcgg acaggcccag
     4261 cacttcgcgc cagacgcggc tgacctggcg gatcagcacg ctcaggttgt cccgcgcctc
     4321 gtcggcgccc gggaccgccg tctggccggc cgcctgtcgt tcggccagct ccttgaggac
     4381 cttgcggtcg atcttgttgt tggcgttgcg tggcagcttc gccagttgca ggtaggtgcc
     4441 gggcaccgcc ggcgccggca ggctgcgcgc cagatgggcg cgcagggcgg cgaccggcgg
     4501 cagttcggcc tgcgcttcct ccagggcgag gaaggccacc agccgcttga cgccacccgg
     4561 cagcacttgc ccgagcacgg cggcttcgcg aatccccggt gtgtgcggat agcccagcag
     4621 ggcggtttcg atctccgtgg ggtcgatgcg gtagccgctg atcttgaact cgtcgtccag
     4681 ccggccgagg tagaccagcg cgccgtcgtc gcgcatccgc accagatccc cggtgcgata
     4741 ggcgcgcggc gcgcccggca ggccgggcag gacgacgaaa cgggcggcgg tgcgttcctc
     4801 gcggccgaag tagccgcgcg ccagcgaacc gccgagcacg cagagctcgc cccgttcgcc
     4861 gcgttgcacc gggcgcaggt tggcgtccac caccgccacc tcgacgcccg gcagcgggtg
     4921 gccgatgggc agggtttcgc cttgccagtc cagcgcgtcc ggcccggaca gggtcgccgt
     4981 ggtgcagatc accgtggttt cggtcgggcc ataggtgttc agcagcacgg cctgcgccgg
     5041 cgcctgggcc tgccagcgct gcacacgttc ggccagcgcc gcctcgccgc cgatgatgac
     5101 caggcgcagg tggggcggca gcggtgtctg cgctcccagg ccgtaggcca gttcgtgcca
     5161 gaaggcggtg ggcaggtcca gtaccgtgat gtcgcgtacc gcgcaggcat cgagaaagcg
     5221 cggcacggat tcgagcatct cgtcgttgcg cagtaccagg caggccccgc tggccagggt
     5281 caggaagatt tcctcgacgc tggcatcgaa gtgcagtggg gcgaactgca ggacgcggtc
     5341 gctggcccgc atggcgtagc gctggcgcgc gccggcgacg aaatgggcca gcgcgtcgcg
     5401 gccgatcatc acgccgttgg ggcgcccggt ggtgcccgag gtgtagatga tgtaggccag
     5461 cgcgtccggc gccaccggcc gcggctggcc gagcaccacg gcggtgggcc ggggctcgtc
     5521 gagcagcagc acgggctggc cggccggcac ccgctcgcgc tgggcccggc aggtgatgac
     5581 cagggtcggg gcggaatcct ccagcaccat ggcgatgcgc gcttcggggc tttccgggtc
     5641 gagcggcacg taaccggcgc cggcccagag cacggccagc agcgcgacca cggtgtccgg
     5701 cgagcgcggc agcaggaccg ccacccggct ttccgtggtc accccctggg cgaccagcac
     5761 gcccgccagc gcgctcaccg cctgcagcag ttcggcatag ttcaggcgca cgccgtcctg
     5821 ttccagcgcc ggggccttcg gcgtgcgcgc cgcgtggttg cccagggcgg tcagcacatc
     5881 caccaccggc ggcaggggtt cgccggccag ccgggccagc ggcggctcgc gcagcagttg
     5941 ccgcagcggc gtggtcgcgg gcgcgcgctg cagggaatcc agcgcggcga tcagttcctc
     6001 gtgcagggtg gccagcaact cgtcgccgta ggcatctgga ttggcctcca ggtccaggcg
     6061 gacaccctcg gcgccgggca ccacgctgat cgacaggtcc tccaccggcc cggccgacac
     6121 cggatgctgg cgggcctgca gatcgccgaa ggtgtcggga cgctcgaacg gcatcaggtt
     6181 gacgaccggg ccgaacaggc cctgtccgcg cccgacctgc cgccgcgcct gggccagatc
     6241 ctggcgcagc cattcgtagc gatagcgctg gtggggacgg ctggcgcgca tttcggccgc
     6301 cacgtcggcg gccagcgcct gcatgccccg atcgatgtcc accggcaggc gcagcggcac
     6361 gatgttcatg gccatgcagg gcacgttcag cgcccgcgag cccagccggg tcatcaccgg
     6421 caggcccagg cagacttccg gcgccgcggt gcgccgggcc agccagccgc cgatggcggc
     6481 cagcagccag gcggcccagt ccacgccgca ggcgccggcg gcgcgttgcc agtcggccag
     6541 cgcgcgcgcc ggcagcaggg cgcgccggcg gcgcacgtcg cgggccagcg ccgcgcccgg
     6601 ggccagggtc acgggcggcg gcgcatcgag caggcgcgcc acccagaaat cccggttgcg
     6661 ctgggcctgg cgctgatagg cgcgggcctc gtcgaccacc tcggccaggc cggcggcgga
     6721 gggcaggcgc gtcatggcgg tgccctggcg ttcggcctcg tagagttcgg ccacccggcg
     6781 gatcagcagc gcatagccgt agccgtccag ggcgatgtgg tggacgcgca ggagccacag
     6841 gtgatggtcg gcggccaggc gcagcagggc catgccgaac agcgggccgt tggccaggtc
     6901 ggggaggctg cgcaggtcgt tgcgaatcca ttgccaggcc ctgtcccagg cctgtccggc
     6961 ggagctttcc gttgcgctca ggtcgatccg gcgcagcgtc caggcggtcc tgtccgggcg
     7021 ctgccagatg tcgtcgccct cggcctcgaa gcgcatgtgc agggcttcgc tggcctcgac
     7081 ggcctgctcc agcgcccgct cgaaggccgc ctcgtccagc gcgccgcgca gttcgacggc
     7141 ttcggcggtc cagtaggccg gactcagggg gtcgagccgc tgtcccagcc agatgcccag
     7201 ttgcgcggcg ctcaggggaa gacgcgccag cgtcggctcc ccggcgacgc ccgtctcggc
     7261 ggaacagggc atctcaacgt ccctcgctca gcagcgacca ccagtgggcc agcgtcggct
     7321 gctcggccac ctggacgaag ctcacctggg cgccggcgcg cttccagcct tcgagcaggc
     7381 tcatcaggcg gatcgagtcc agcccgacat ccagcaggtt gtcctcgacg ctgaagtccg
     7441 aggccggcat gccgagcatc tgcgcgactt cctggtgcag ggcctcgatg ctggccggca
     7501 gcccgccggc cagcgcggcg atcaactggt cggtgtcgcg caccacgccg gcgcaggcga
     7561 ccacgtagtc cagcgcctgg cggtgccgct ccggcgagaa gtcggccagc gcgtccccga
     7621 ccatgatcgg ctggacgtcg cgcatgaagg cgtccacgca ggtggtctgg cagccgatgt
     7681 gggcgtagat gccgcagacc atcagttgat cgcggccggc cgcctgcagg cgctcgcgca
     7741 ggtcgctgcg gatgaaggcg ctgtagcgcc acttgtccag caccacgtgg ttttccctgg
     7801 gcgccagcgc ggcgatgacc ggcgccccct ccggtttggc cggcaggccg gggccccaga
     7861 actcgttgag cagcgcccgg tccccggccg gctgcacggc cggctgggcg gtgtagtaga
     7921 ccggcacgcc ggcggcgtcg caggcgtcga tcaggcggcg gatgttggct accagttgcg
     7981 ggatcggcgc ggcactacgg tcgtagaaat cgatgaagta ttcctgcatg tcgtgcacca
     8041 gcaacgccac ccgtttcggg tcggcctgcc agtcgacacg gccggaggga aaggtttctg
     8101 cggcgggcat gggatagctg gcaatgcggg ggatagccat gggatttctc gcttggaatt
     8161 ttggagttcg gatttgcgga gccgtatggg cgtcggacgt cgtcaggccg tggcctgcag
     8221 gcgtgccgcg atgcgttcgc gcagggcgcg cttgtcgatc ttgccgacgc cggtcttggg
     8281 caactggtcg acgaactcga tgcggtccgg caccttgtag ccggcgacgc cgcgttcgcg
     8341 catgaagcgg ttgatctcca gcggccgggg cgcttcgccg cgcggcacga tgaaggcgca
     8401 ggtgcgctcg ccgaggaagg cgtcgggcat cgcgaccacg gcgacatcca gcacggcggg
     8461 atgcgccagc aggtggtttt ccacttcctc ggcggccacc ttgtcgccac cgcggttgat
     8521 ctggtccttg tcgcggccct cgacgatcag gtgcccgctg ggcaggcggc gggccacatc
     8581 gccggtgcgg tagaagccgt cgcgggtgaa ggagcgggcg ttgtgcacat cggcgcggaa
     8641 gtagccgcga atggtgtagg ggccacgggt gatcaggtgc ccggtttcgc ccggcggcac
     8701 gtcgcggtcc tcgtcgtcga cgatgcgcac ttcgtcgtcc ggggagatgg ggcggccctg
     8761 ggtgccgacg atcagctcct ggggatcgtc gaaccgggtg tagttgacca gtccctcggc
     8821 catgccgaac acctgttgca gcttgcagcc gagcaggctg tcgacccgtt gcgcggcttc
     8881 gtcgctgagg cgcgaaccgc cgacctgcag caccttcagg ctggccagtt cggcctgccg
     8941 ggccggcgcg gcctccatcc aggccagcgc cacggagggc accagcgcgg tcatgtcgac
     9001 ccgctcgcgg gcgatcaggg cgaaacaggt gtcgggactg ggatcgggcg ccagcaccac
     9061 gctgccgccg gcgtagagga cgcccaggat gcccggcgaa ctcatcgcga agttgtgggc
     9121 cgccggcagg gcgcagagga acacggtgtc cgggccgagg ccgcagatct cggcgctggc
     9181 ccgcacgctg tagaaatagt cgtcgtgggt gcgcgggatc atcttcggcc gtcccgtgct
     9241 gccgcccgac agttgcagga aggccagcgt gtcggccttg ggttccggca gcggcagcgg
     9301 ctcggcgtcg agccgctcga aggggatgaa ttcctcggcc tcgccgacca ccacgacggt
     9361 gctcagggtc gctgcttcgt cgcggatgtc gcgggccatc tggcgatagt cgaaaccggc
     9421 gtggcgatcc cggatgacca gccccttggc ttcggcgaag gcgcagaagt agccgatttc
     9481 ggcccggcgg tgggccggca gggcgaagac cggcagggcg cccaggcgca gcagggcgaa
     9541 gatgaccatc acgaattcgg cgatgttggg caactgcacc acgacgcggt cgccggcggc
     9601 gatgccttgt ccgaccagcc cggccgccac ccggtcgacg cgggcgtcca gttcggcgta
     9661 ggtccagcgc cgctcgccgc agaccagcgc ggtgcgtccg gcatggcggt cggcgccggc
     9721 gcgcagcagg ctgtccagcg gttcgccgcg ccagtagccg gccgcccggt agcgcgcggc
     9781 gaattcggcg ggccagggcg tgaagtccgc gccttcggcg gaagaagagg tcggggtcga
     9841 ggtgctcatg cccggttctc ctcggccagc gcgagcccca tggcgcccag catggtgcgc
     9901 agcttggcgg cggtttccgc cagttccagc gccggttcgg agccggccac gatgccggcc
     9961 ccggcataga gggtcgacga ctgctcgccg acttcggcgc agcggatggt caccgcccat
    10021 tcgccatcgc cctgcgcgtt gcaccagccg accaggccgg tgaagaagcc ccggtcgaag
    10081 ccttcgaacg cctggatgaa ctcccgcgcc tcggcggtcg gatagcctcc cacggccgga
    10141 gtcggatgca gcgccagcgc cagttccagc gaggtcgtgg ccgggtcgcg cagcgtgccg
    10201 gtgacttcgg tggacaggtg ccacatggtc ggggtcgaga gcagcgacgg cgcttcgggg
    10261 accagcagat cggtgcaata ggggcgcagg gcctcggcga cggcttccac caccagcgcg
    10321 tgctcgtgca ggtccttggg cgagcgcagc aggttctcgg cgcgctggcg gtcctcggcc
    10381 gggtcgctgc tatgcgggat ggagccggcc agcgggttgg aaatcacccg gttgccgtgc
    10441 cgggccagca gcagctcggg gctggcgccg atcaggctgc ggcgctcgcc gttggcggtc
    10501 ggcagcggaa tggcataggt gtagcccagc gggttgcggc tggccagggt ctgcagcagt
    10561 tcggcctgat ccagctccgc ctggatgtgc agcgagcgcg acagcaccac tttctgcaac
    10621 ttcccgtcgg cgatccgctc caaggcccgg ctcacgttct gctcgtagac cgcctcggcc
    10681 ggttcgctgc gcgccgcgac cgtgcgtacc ggacgcggcc cgccgaccag cgccgcgcga
    10741 ccgccgccag ccagttcgac atgctcgggg atgaacagat gggccgcagc gcccggcagg
    10801 aaggggatgg cgccgatcag ccagccggca tgcccggcct cgctggcctg acgcagaaaa
    10861 gcggccgcat gcccggccag ggcggcgggc gaaccgctca tgaccagcgg cagggtcgcg
    10921 gccacgccat gcgccagcag ggtctggccg ggcgaagcga acatgcaggc atcgcggtgg
    10981 taatgggtga acagcacctg cggaccgcag ggttcggaaa aggactgcgc aagctgtgtc
    11041 tgttgaacaa aactcatgat gcctccttac ggctagagga cgagcaggac cacctagggg
    11101 aaggcactgg cgccttcatg tatgtaataa tgctagcgtc aaatgataat aagtatcaac
    11161 attaaacaat ataaaaaggt acttgagtat tgatgtcatt ttgatttttc gtctttaacc
    11221 atagttacat caattggtta cggcctattt acatcacttg gagagagcat gaatccggac
    11281 caatccctgc aatcggaagc acgaacgaaa ccttttgcag caatttcacc caaggtgctc
    11341 atcgccctga tcgcctccct gcagttcacc tacattctcg atttcatgct ggtcctgccg
    11401 ctcggcccgg atttggccaa aggtctcaac tttcacggta atcaagttgc atggctaaca
    11461 gccagctata catttgcgtc cttgctgtcc ggtctgttca ccgtgccgcg cctggatcgc
    11521 ttcgatcgcc gcaaggccct gctctggagc ctggtgggac tggcgctcgc ttcgctggcc
    11581 tgtaccctgg cgcatgattt gccgagcctg ctgctcggac gggccgtcgc cgggctctgt
    11641 gccgccccgg cgatcgccac cggcatggcg atcctgatcg accagacgcc gccgccacag
    11701 cgcgggacag ccatcgccaa ggtcatgacc gggttttcca tcgccaccat cgccgggatt
    11761 cccctggcgc tggaactggc ggaccacttc ggctggcagg cgcccttcgt gctggtggct
    11821 gtgctggtgg tgctggtcgc cttcgccgtg gcccatctgt tgccgccgct gaccgcccac
    11881 ctgcaagggc cggctggcaa gccgtcgctg gccatgctga gccgtcccgg cgtgcgcctg
    11941 gccacgctgt tgcaggggct caaccagttc tccgccttcc tggtgatccc gagcttctcc
    12001 gcgttctacc tgctgaacct cgattacccg cgtcagcaac tgggtacgct gtacctggtg
    12061 ggcggtctgg tggcgctggg ggccatgcaa ctggccggac gcctgggcga tcgacacggc
    12121 cactggctgc cggtcggcgt ggccagcgcc tgtttcgccg tcggcctgct gccgttcttc
    12181 ggcctgagcg ccttgccgct gatgctgagc ttcgtgctgt tcatggccgg caacgccgcc
    12241 cgcacggtct gcctggcggc cgccatcagc catgttccgg cgccgccgga gcgcgccggt
    12301 ttcatggccc tgcagaagat gacccaggat ttcagcgtgg ccctggccgc cggcgccgcg
    12361 gcgctggtgc tgggtggcgg cgacgggccg ctgacccata ccggactgct cgccaccctg
    12421 gcgatcgtcg gtgcggggct ggtcctctgg gtgctcgaac ggctgcggcg aaacctgcag
    12481 ccgccggcct ga
//
