LOCUS       BGC0002536             27195 bp    DNA     linear   CON 07-DEC-2022
DEFINITION  Kitasatospora azatica KCTC 9699 BR98DRAFT_unitig_0_quiver.3_C, whole
            genome shotgun sequence.
ACCESSION   BGC0002536
VERSION     BGC0002536
KEYWORDS    .
SOURCE      Kitasatospora azatica KCTC 9699
  ORGANISM  Kitasatospora azatica KCTC 9699
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            JQMO01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 17:56:43
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 27195
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..27195
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002536"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..27195
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1667..2935
                     /locus_tag="BR98_RS33590"
     CDS             1667..2935
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 243.7; E-value: 3.8e-74)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.2"
                     /locus_tag="BR98_RS33590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_157538041.1"
                     /transl_table=11
                     /translation="MPPNRGIGVSEISGRAKDLMYRQFGGLPRSFWIVFAGQFVNRIGS
                     MAVPFLVLYLGNQGLSASDAGTVLAAVGLGGLVSQPMGGVLADRFGPRIALVAGLSASA
                     VSIVLLGAARGLPTVLAAAVLVGAVADIYRPAAAALVAAVVPAQSRPRAYSLIYWAVNL
                     GVGLAGLLAGLLATYGYGLLFLVQAAAAAAFALLVAILVPGRSATGWSPPATSRSTTVG
                     LLRDRLLLALIGLNIVSGLINAQITVGLPLAIKNSGLSSVVYGAVFMVSGLLIGVLQPL
                     LAGWLERFDRIVVLSVSWAVFGLGVAATGLARTAPEYLATVVVWTLGEIGAASFVGAII
                     ADLAPAHAQGRYQAAFGWSYAAAQLLGPLGGAYLYGSVAPWALWWSCGLLAVLGAAGGL
                     ALVAPVRRRSAAPASTPLLENAL"
     gene            2932..3939
                     /locus_tag="BR98_RS33595"
     CDS             2932..3939
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012880.2"
                     /locus_tag="BR98_RS33595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-dependent dehydrogenase E1
                     component subunit alpha"
                     /protein_id="WP_157538043.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-08, bitscore:
                     25.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="DXP_synthase_N (E-value: 7.7e-08,
                     bitscore: 22.2, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAMRNHGSYPPTSTAIDLLELYRRMRVLRRMDEVLAELVADKL
                     VTGPMHLGIGQEATGIGATAALRPGDLVTATHRPHAQYVGLGLSLGRTFAEMMGRADGQ
                     CGGRAGHMLIADQERGLLGPSGIVGHSLLLAVGHGFAQRRAGQGAVTLCVTGDGAVNSG
                     AFNEALNMMALWQLPVVVLVENNGYGLSVRLDRHSRETELYKRAAGYGVPGVLVDGNDV
                     EAVRDVVSAAAERARAAQGPTLVEALTFRNTGFSSSDRGGYQDPGEGAEFTDPLELAAR
                     RLVAGGTTAARLAEVDQRAAQEVEEAVVFAKASPWPDPAELFEYAAKWDQGALL"
     gene            3936..4934
                     /locus_tag="BR98_RS33600"
     CDS             3936..4934
                     /EC_number="1.2.4.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     352.5; E-value: 2.4e-107)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070717.1"
                     /locus_tag="BR98_RS33600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="WP_232247812.1"
                     /transl_table=11
                     /translation="MTGTTTARMTYAQALNDALRLEMLADDRVVVLGEDVGRYGGVFSV
                     TRGLMDEFGADRVLDTPISENGIVGAAMGMAMSGLRPVVEIMYTDFLCLALDSIANGVA
                     AFPFAYNGQVTMPVVVRTQGGAGINAGPQHSKSLEAWTAHLPGLHTVLPSNPADAKGLL
                     TAALRSDEPVILVEHKLLYSTEGEVPSGEHLVPLGTAQVVRPGTDATVLALSRMVPEAL
                     VAAARLAEQGLDCEVVDVRSLRPLDVATLAASARRTGRVVVAAEAWVRYGPSAEIAAAV
                     TESAFDDLRAPVVRLGSLGVPYPASPALEQAVLPDAAAIQQAVEQLVKRTP"
     gene            4969..5748
                     /locus_tag="BR98_RS33605"
     CDS             4969..5748
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (12-175). E-value: 6.3e-13.
                     Score: 40.9. Matches aSDomain:
                     nrpspksdomains_BR98_RS33605_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     247.7; E-value: 2.1e-75)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985386.1"
                     /locus_tag="BR98_RS33605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_035850920.1"
                     /sec_met_domain="adh_short (E-value: 5.1e-34, bitscore:
                     108.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERSTQVRFLDKSVLVTGGGTGIGRTTALAFAAAGARVTVSGRRP
                     EPLAETVALIEAAGGSAVALPADITEESEVAALVEQVIARHGRLDVACNNAGVPGSGRR
                     LHEFGLADWRRITDTNLQGVWLSMKYEIQAMLQQEGGGAVVNVASIAGLVGYLDAAPYT
                     AAKHGVVGLTRSSAIDYGPKGVRVNAVCPGPVLTPMLEQARRDRGPSADEFYLRNIPLG
                     RLCRPEEVASAILWLSSDEASYITGQALGVDGGWTAH"
     CDS_motif       5005..5082
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BR98_RS33605_0001"
                     /evalue="4.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="BR98_RS33605"
                     /protein_end="38"
                     /protein_start="12"
                     /score="16.1"
                     /tool="antismash"
                     /translation="SVLVTGGGTGIGRTTALAFAAAGARV"
     aSDomain        5005..5493
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BR98_RS33605_PKS_KR.1"
                     /evalue="6.30E-13"
                     /label="BR98_RS33605_PKS_KR.1"
                     /locus_tag="BR98_RS33605"
                     /protein_end="175"
                     /protein_start="12"
                     /score="40.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SVLVTGGGTGIGRTTALAFAAAGARVTVSGRRPEPLAETVALIEA
                     AGGSAVALPADITEESEVAALVEQVIARHGRLDVACNNAGVPGSGRRLHEFGLADWRRI
                     TDTNLQGVWLSMKYEIQAMLQQEGGGAVVNVASIAGLVGYLDAAPYTAAKHGVVGLTRS
                     "
     gene            complement(5799..6770)
                     /locus_tag="BR98_RS33610"
     CDS             complement(5799..6770)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 274.5; E-value: 1.7e-83)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019474.2"
                     /locus_tag="BR98_RS33610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_035850922.1"
                     /transl_table=11
                     /translation="MTLNTGNADRLDSELARAAQLQPYVAFADPLGSRRNFARSVKISR
                     ALRGKAPAEASVRTEDTSFTVPEDGRRIPVRIYRPDGLQESAPVLIYFHGGAFVAGDLE
                     TEHDRLLALALDTDCAIVSVEYRRPPENPFPAPTEDCYAAVRWVAAEAESLSLDAGRIA
                     IGGSSAGGTLAAATALMCRDRQGPELVLQLLLFPALDDRLDSDSMRRYPRTAAWHIEDS
                     HHMWRHYLGPAFGTEDPYAVPARRVDFTGVAPAYVLVAEVDALRDEGIAYAARMLEDGV
                     SVELHHFAGGFHSFDAAVPHAGLSVRALAEQSAALRRAFARN"
     gene            7322..8365
                     /locus_tag="BR98_RS33615"
     CDS             7322..8365
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BR98_RS33615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157538045.1"
                     /transl_table=11
                     /translation="MVKAKTGMEALAWRSVESLSNVLYILCAGALWQHTSNVVWHLSGV
                     PMVVMLVLAVAHWLWYWQLHLFEYDCGLAFGSTTLVAQIAGAQGPKLISWKVGSRRWIR
                     FPVHTAFFGMFFCLPTMTTDLLLLAVVLNIYNVIGSILYDKRLITLAGDAYRPYLDVTG
                     LIWPPVYRMPRGAADLEMPAPQHWRKPLMHLPGLVVGIGLGVLYHFLIGAKADTPIEMA
                     KAGGAGLLAAVLSGLVIGTISKPEAKDWGQQQTDLSTTVALSAAIGVVTWATIGWVQTG
                     SAPAFTAFLPLWFTVQYLGHVFAFLANRKKWSVSLIPVETTAATAAQPAKSASVPVAAA
                     VAEPRSV"
     gene            8365..9726
                     /locus_tag="BR98_RS33620"
     CDS             8365..9726
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BR98_RS33620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_035850923.1"
                     /transl_table=11
                     /translation="MSLRTTPAPAARTEVLDIPVRVPATRTPYWHTDSPLLAVTHVDPQ
                     YARLRELFPEGWVHLAQAKSLIDGVAALEVPEVVPAAVHLRRVAPLLTAAAHELIQFAE
                     TEQVGAAAPAAEQARTAADRLLHYAHTQVWKEIILSEPVPGTPWLYCGPLNTWAMNTVN
                     LPIGMLVVTPNASLQQEIEAVNVLLPGIQPVIGGVLGGAAKSIQPEHPTMQIVDLLLAG
                     GESRVGHKNFAHFFPLEAPHSRVEGPEFTVVFANVHADRLERCSLNLLDRYQEAGEATD
                     LQETLRASLRWFRCHDLAHFWRRTAVEGNGSPAPGLTPFEAMTLEETYADVLGLVSAAS
                     FFPGTSLGQAYLAELLRYLSRRHHHFADSGAAMLTAGWLVAKGVSLQNRDDHWLDKALP
                     LLEELAVCLHRALWEADSTDLDELRDALAIGTRYRDGLAELYQTIPTDLEYTFG"
     gene            9734..10510
                     /locus_tag="BR98_RS33625"
     CDS             9734..10510
                     /EC_number="1.-.-.-"
                     /NRPS_PKS="Domain: PKS_KR (4-156). E-value: 3e-10. Score:
                     32.1. Matches aSDomain:
                     nrpspksdomains_BR98_RS33625_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     210.7; E-value: 4.1e-64)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007497762.1"
                     /locus_tag="BR98_RS33625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_051970762.1"
                     /transl_table=11
                     /translation="MHNRTVIISGASSGIGLATARRFAAAGDTVVNFDLQPPAPEDAVG
                     EWVQVDVTDFAQVAAAVDTVAATHGGIGVAIANAGISLRRTFLEMTEKDIRKLLDINLM
                     GVIALWQAAARHMVEAKEGVLLATASTNGTAGYPYYADYNASKAAVLALSRSLALELSP
                     YVRTACVSPGYVMTPMQRAEYTDEMLAEVNERIPAKRHADPAEIGEAFFFLASPQAKFI
                     TGQQLIVDGGELAGGTASAHGVVFAATQDSEGNTSA"
     CDS_motif       9746..9814
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BR98_RS33625_0001"
                     /evalue="1.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="BR98_RS33625"
                     /protein_end="27"
                     /protein_start="4"
                     /score="14.7"
                     /tool="antismash"
                     /translation="TVIISGASSGIGLATARRFAAAG"
     aSDomain        9746..10201
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BR98_RS33625_PKS_KR.1"
                     /evalue="3.00E-10"
                     /label="BR98_RS33625_PKS_KR.1"
                     /locus_tag="BR98_RS33625"
                     /protein_end="156"
                     /protein_start="4"
                     /score="32.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVIISGASSGIGLATARRFAAAGDTVVNFDLQPPAPEDAVGEWVQ
                     VDVTDFAQVAAAVDTVAATHGGIGVAIANAGISLRRTFLEMTEKDIRKLLDINLMGVIA
                     LWQAAARHMVEAKEGVLLATASTNGTAGYPYYADYNASKAAVLALSRS"
     gene            10507..11283
                     /locus_tag="BR98_RS33630"
     CDS             10507..11283
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BR98_RS33630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_035850924.1"
                     /transl_table=11
                     /translation="MTITQEQPATLPAVADVLGAAAERCETVDLGAGLTAFVISRPGRV
                     LNLSDQERIYQALIPVTTSSFGADMTPYWTQRSKEGYLERLAEFVLISDSEGTMVGWTG
                     FHILPYDTFTLVYLDSTGMVPTRQSGGVMRALMRRQVVDSGLADCPADRPVYLTARSES
                     PIFYRLMRKLLDSGELYPHPHQPAPEDVVEAARHLAKWLGQEDILDAPSLTVRGAYQAL
                     DELYGELPTTGDADLDKLFRGQLGPLDAFLLVGRAR"
     gene            11307..12110
                     /locus_tag="BR98_RS33635"
     CDS             11307..12110
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294:Nitrilase/cyanide hydratase and apolipoprotein
                     (Score: 218.7; E-value: 1.5e-66)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012993.2"
                     /locus_tag="BR98_RS33635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbon-nitrogen family hydrolase"
                     /protein_id="WP_035850926.1"
                     /transl_table=11
                     /translation="MRLTLIQAETDRTLPFEQRIAVACEQIAACHGADLVVLPELWATG
                     YFHFDDYAATAQPRSGEAARALAAAARAAGVHLHAGSLVERDEQGRLYNTSLLYGPDGE
                     LLHAYRKIHLFGYDSRESALLTAGQGAAVVPTPFGRIGLAACYDLRFPELFRAQTEQGA
                     ELLLLSAAWPLARIEHWQLLLRARAIENQAMVVAVNAGGRQGEVELGGHSMVVDASGQV
                     LLQTGSDPEIRSVDLDLTSTAQARRTFPALADRRPPSALEAVPEI"
     gene            12143..13135
                     /locus_tag="BR98_RS33640"
     CDS             12143..13135
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 299.3; E-value: 5e-91)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019474.2"
                     /locus_tag="BR98_RS33640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_198042327.1"
                     /transl_table=11
                     /translation="MTLIVPDGIDPELARSAGLQPDLDFADPPHVRASLNRAFKFSKAM
                     RPAPSALDGLTTTDRHVPAREGSPDIPVRVYDAADRPAASAALVFFHGGAFVAGDLETE
                     DARCAEIARRTGALVVSVDYRLAPEHPFPAGFQDCYDVLVWVADQAAELGVDPNRIAVG
                     GSSAGGALAAAVSLAARDLGGPRIMLQMLLYPVIDDALDTRSMKEFDTTPGWNQPNSVH
                     MWNHYLGTGDRGEVSPYAAPWRATDLSGLPPAYVMTAEFDPLRDEGIRFAVRLLAADVP
                     TELHQFPGAFHGFDAAAPEATLTRRSLDEQCAVLLRAAAMSVEPAPADA"
     gene            complement(13206..13463)
                     /locus_tag="BR98_RS33645"
     CDS             complement(13206..13463)
                     /NRPS_PKS="Domain: PCP (14-81). E-value: 8.6e-14. Score:
                     43.4. Matches aSDomain: nrpspksdomains_BR98_RS33645_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.2"
                     /locus_tag="BR98_RS33645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_035850928.1"
                     /sec_met_domain="PP-binding (E-value: 8.5e-14, bitscore:
                     42.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEGQTPSLAVPVDEVAQLWGRLLHREDVAHDVSFIELGGDSLLI
                     IAMLSEIEEQFEVYLEAEEVLADLTVRGIASAIAKARAEA"
     aSDomain        complement(13221..13421)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BR98_RS33645_PCP.1"
                     /evalue="8.60E-14"
                     /label="BR98_RS33645_PCP.1"
                     /locus_tag="BR98_RS33645"
                     /protein_end="81"
                     /protein_start="14"
                     /score="43.4"
                     /tool="antismash"
                     /translation="EVAQLWGRLLHREDVAHDVSFIELGGDSLLIIAMLSEIEEQFEVY
                     LEAEEVLADLTVRGIASAIAKA"
     CDS_motif       complement(13335..13364)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BR98_RS33645_0001"
                     /evalue="1.50E-03"
                     /label="PCP_mC"
                     /locus_tag="BR98_RS33645"
                     /protein_end="43"
                     /protein_start="33"
                     /score="11.8"
                     /tool="antismash"
                     /translation="SFIELGGDSL"
     gene            complement(13574..15208)
                     /locus_tag="BR98_RS33650"
     CDS             complement(13574..15208)
                     /NRPS_PKS="Domain: AMP-binding (30-437). E-value: 7.7e-53.
                     Score: 171.3. Matches aSDomain:
                     nrpspksdomains_BR98_RS33650_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     192.8; E-value: 1.3e-58)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.2"
                     /locus_tag="BR98_RS33650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_035850930.1"
                     /sec_met_domain="AMP-binding (E-value: 4.5e-53, bitscore:
                     170.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTDHPSASTEAVDDPRPGVLMDWLRAARTGGVRLVERGETRLVP
                     WSQVHQDVEALAAGLARRGVGPGDRIGIRGHNSYEWLALDLALLHLGAVPVAVPVPDFK
                     GTSNAQVAARYGLAAMFAGKESRSGTDGPEVGALEQVLTEPAVEPVADPPAPEGEQVRV
                     SDREVFTLAFSSGTAGRVKCLLLAWPGVQALVEAQSAAYPCGPEDRIMIALPLSTFQQR
                     YLCYLAIRNGCEVIMTTAARMLPTLPLTKPTIMLGPPNFYEFVEKRYRNLDPDKRARLD
                     AAAASAEQLPDAQARELRRSVFREFHDMYGGSLRLMLVGSAPVRPGMLEFFTHAGFELY
                     QIYGMTEIGYLTWNRREGNRLGSVGTEVYPGTVRIGEDGEVLVQHQWHLCVGYEGESPE
                     DTALVFRAADTIATGDIGEFDADGYLHLKGRKKNIIITTGGQKIQTEDLEAELCRPSSV
                     HQAALFQVETGVLAAAAFYEGSEEQTRAAVLGAITQINSRLGTDLQIRHLALLEGALTP
                     ESPLLNRNLKINREAVRTAVADRLAPL"
     aSDomain        complement(13898..15118)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BR98_RS33650_AMP-binding.1"
                     /evalue="7.70E-53"
                     /label="BR98_RS33650_AMP-binding.1"
                     /locus_tag="BR98_RS33650"
                     /protein_end="437"
                     /protein_start="30"
                     /score="171.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="GGVRLVERGETRLVPWSQVHQDVEALAAGLARRGVGPGDRIGIRG
                     HNSYEWLALDLALLHLGAVPVAVPVPDFKGTSNAQVAARYGLAAMFAGKESRSGTDGPE
                     VGALEQVLTEPAVEPVADPPAPEGEQVRVSDREVFTLAFSSGTAGRVKCLLLAWPGVQA
                     LVEAQSAAYPCGPEDRIMIALPLSTFQQRYLCYLAIRNGCEVIMTTAARMLPTLPLTKP
                     TIMLGPPNFYEFVEKRYRNLDPDKRARLDAAAASAEQLPDAQARELRRSVFREFHDMYG
                     GSLRLMLVGSAPVRPGMLEFFTHAGFELYQIYGMTEIGYLTWNRREGNRLGSVGTEVYP
                     GTVRIGEDGEVLVQHQWHLCVGYEGESPEDTALVFRAADTIATGDIGEFDADGYLHLKG
                     RKKNIIIT"
     gene            complement(15277..16518)
                     /locus_tag="BR98_RS33655"
     CDS             complement(15277..16518)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 223.2; E-value: 6.4e-68)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.2"
                     /locus_tag="BR98_RS33655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_035850933.1"
                     /transl_table=11
                     /translation="MSTDTDAERSQAPDRSILQVVLKSPRPVKVLVAGVFLNRTGSFFS
                     TFLVLFLRQLGFSLTQMPIVLLFVGAATPIGSLLGGWAADRFSRRIALVSSTLLASGGL
                     AVIGLSPNRNTALVGVFLAALFAQAYLPAASALLVDNTRERDRVPTFAFFRLALNLGAA
                     LGPVIAVFIAPHGLKGLFLASACCYAVFAAVLWFGLRHPSAKPTDAEAGPAADQDRTGH
                     TPLGLLAFFGAVLGITVVYVQYSSTVSLAVSAAHSASAYASLLTLNGVLVIIAEMPLSA
                     WTRRLPWWVPMALGTAAMAIGIAMCGALHSYLLIALGVVVWSAGEMLFSPVVSSATAAL
                     SPADRIGRYQGYLATVQAVAFALGPAIGIFVYGRSTGALWAACLVVGVLACAGIAVAGR
                     SAHRLAARSASASA"
     gene            complement(16515..17603)
                     /locus_tag="BR98_RS33660"
     CDS             complement(16515..17603)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 82.6; E-value: 5.2e-25)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134220.1"
                     /locus_tag="BR98_RS33660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_232247814.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.3e-13, bitscore:
                     40.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 6.4e-10,
                     bitscore: 29.2, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESHVVGSYDPEVLEALVRKVAPDGLLTYDELLVEPVARLAASV
                     GLPYTDAEAVRHCKDKSALRALLSEAGVSPVRFAVALTEQEAIRAADEIGYPVVLKPRA
                     LGGSIGVVRVQDEKELLTAFTVAADAQAPDGTASAHSGVLIEEYLDGPEYSVDCVTWEG
                     RTTPLVVAEKEIGFPPYFEETGHIVPAAEHPDLAAAIDMVVQAHAVVGLDRLVSHSEFK
                     LTSRGPRIVEINVRLGGDLIPYLGHLSSGVDVAGAAASVAVGLEPDLSTDRSVHAAIGM
                     IYPEQDIRLESVALRGEAEHPGLEQFTTFVPAGTEVKLPPEGFLSRIAIAIVTAESRPD
                     CQARLAAVRADVVVEGTPLGAR"
     gene            18255..19694
                     /locus_tag="BR98_RS33665"
     CDS             18255..19694
                     /NRPS_PKS="Domain: Aminotran_1_2 (127-409). E-value:
                     4.3e-18. Score: 57.4. Matches aSDomain:
                     nrpspksdomains_BR98_RS33665_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 267.3; E-value:
                     3.6e-81)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132759.1"
                     /locus_tag="BR98_RS33665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_035850945.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-18, bitscore:
                     57.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTEWSTASLDLHLELDLSRRHGRADRLVAAIREAIDAGRLLPGG
                     KMPSTRSMALQLEVARGTVASAYEQLVVAGYLEVSHGSGTRVAPLRSRSEDARTSSGPA
                     AAGSPAPSWNLRPGLPDVTLFPRTAWVAATQRVLREAPAEALDYGDPRGRPELRLALAN
                     YLGRARGVVAHPDRIVVCHGFTQALGLLAKVIADRKAPTMTFEDPSYPLFREIVRTAGL
                     STLTAEVDDQGLRPETLGPSSAVLVTPIHQYPLGAELSARRRQELIAWAREADAVIIED
                     DYDGEFQFHRKPTGALQALDPGRVVYAGTTSKTLAPGLRLSWLVLPPDWVEPVAVAKRN
                     ADQHSAALGQMVLAQLITSGAYDRHIRRCRAQYRERRARLAEVLADHVPQVELVGPSAG
                     LHALVRWAEDGPSERDMLLAAKRESLALSTLGPYWATPGPHQPGLVLGYASPPQHGYAG
                     ALAALTRAFGRVFDQGTRNTP"
     aSDomain        18636..19481
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BR98_RS33665_Aminotran_1_2.1"
                     /evalue="4.30E-18"
                     /label="BR98_RS33665_Aminotran_1_2.1"
                     /locus_tag="BR98_RS33665"
                     /protein_end="409"
                     /protein_start="127"
                     /score="57.4"
                     /tool="antismash"
                     /translation="TAWVAATQRVLREAPAEALDYGDPRGRPELRLALANYLGRARGVV
                     AHPDRIVVCHGFTQALGLLAKVIADRKAPTMTFEDPSYPLFREIVRTAGLSTLTAEVDD
                     QGLRPETLGPSSAVLVTPIHQYPLGAELSARRRQELIAWAREADAVIIEDDYDGEFQFH
                     RKPTGALQALDPGRVVYAGTTSKTLAPGLRLSWLVLPPDWVEPVAVAKRNADQHSAALG
                     QMVLAQLITSGAYDRHIRRCRAQYRERRARLAEVLADHVPQVELVGPSAGLHALVRWAE
                     D"
     gene            complement(19691..20968)
                     /locus_tag="BR98_RS33670"
     CDS             complement(19691..20968)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024925.2"
                     /locus_tag="BR98_RS33670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_035850947.1"
                     /transl_table=11
                     /translation="MSELPPLDGLDVVLAMRQGLLTRHDHVETMFRLGLAVHLVTEDAG
                     AQQDPRYASVRLLPSGSATGALLDAVKDVLHQRDAAFAVTFQETDIEAVGEANAARGVS
                     WSRPVADATARDKARQRAHFAAAGLPTPGHWAIGDRQLTAGLPEVGYPCVVKPTRGASS
                     SHVELVADAAGALRVLAEIRTLAASGQNHFYDQLDDSWALLEEFLPGEEVTCDGVVVDG
                     EFQLGGIHSKVLSPPPFFEEDLYTLPGVDQATEEELTAVMRRLSRSLDLETCLLNAEFR
                     KDTEGRFRLVEFSTRISGGHVYRNIRDAHRIDLVEAFLLAAAGRSAAARAAAARRTPAR
                     LATCIRFVYRSGTVAANQVGEAWRHPGFRAYYALAAPGDRIGHAPEGFDICGLLSVWST
                     PDPAGHPIGIHQLAAEVEALLDIRVD"
     gene            complement(20961..22196)
                     /locus_tag="BR98_RS33675"
     CDS             complement(20961..22196)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 209.4; E-value: 1e-63)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.2"
                     /locus_tag="BR98_RS33675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_035850950.1"
                     /transl_table=11
                     /translation="MTALTDAAPGTSPRRSVATVVRHAPRPVKLLVTGVFVNRLGSFFA
                     TFATLFLQSRGFSGALLTYALTAIAAASMIGSWAGGVLAGRYGNHRVIVLSMAASSASL
                     VLLSQAHQHLTVGLAVCLVSTTSQAYVPAASTLLAAHSSPEDRVPIFALFRLALNLGSA
                     VGPLLAGLLALHSFTTLFAVNAATCALCAAVLQWGARSRSGSDGPQQQDEPAPDDRAGA
                     AERARTGQVRILCGLLFVVAAVYALHLSALPLQLTADGQSAAFYAMLLSVNGFVVLGGE
                     LPISSVTRRAPWRVPLAGGVLVMATGLVLAGLLRQSWAIIGGIVLFTVGEMIFAPVANA
                     AVAALAPQSQLARYQGLLAVAQTAGFTIGPAVGVALWNEARHGFWIGVLALAAVLALAI
                     LLIGTTRGETNE"
     gene            complement(22193..23296)
                     /locus_tag="BR98_RS33680"
     CDS             complement(22193..23296)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000941.1"
                     /locus_tag="BR98_RS33680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitric oxide synthase oxygenase"
                     /protein_id="WP_051970766.1"
                     /transl_table=11
                     /translation="MLWREAEAFYRLPELSHLPKARLAEVRRAIETDGSYQHTPDELLI
                     GAKVAWRNHARCIGRMHWRSLRLLDFRHCRTAEEVAQACWEHLRQSTNKGQLRSVITIF
                     APRTAQGEIRILNPQLIRYAGYRQADGTVIGDPLHVEITELAQALGWNGTGGAFDVLPV
                     IIQMPGDHPRAFDVPADALLEVPISHPELPGIAELGLKWHANPAVSNMGLEIGGISYTA
                     APFSGWYVGSEIGARNLSDTYRYDVLPDVAACMGLDTRHDRTLWKDRALVELTYAVLHS
                     YRQAGVLIVDHHSAARQFLNHVDAEGQAGRPVPTQWSWVNPPLSASATPTYHRTYDAPD
                     FGLRPNFVSQDTVLSCPVTGAVRAVEQ"
     gene            23744..25780
                     /locus_tag="BR98_RS33685"
     CDS             23744..25780
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609606.1"
                     /locus_tag="BR98_RS33685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_035850953.1"
                     /transl_table=11
                     /translation="MTGSRTNVCIIGAGPRGLSVLERLCANERAQPLCSALVVHVVDPF
                     QPGAGAVWRTDQSRHLLMNTVASQISVYTDDSSQIDGPIEPGPTLYEWARQLAGSDGAQ
                     GFDGAQGFDGAHGFDGAQELDGAQGFDDQTLAEARDLQPNTYPTRAFYGSYLHDSFRRV
                     VDRAPEHVTIQVHRSRAVAVADSRGSGETQAVCLENGLWLDDLNAVVLAQGHVPTQLSS
                     REERTAELARAHRLTYIRPGNPADQDLSGVLPGQNVLLRGLGLNFFDHMALFTMGRGGV
                     FVRAADGRLAYQPSGLEPRLYASSRRGVPYHARGENEKGAFGRYFPKLLTAQYVAALRE
                     RAGKGDEVRFGTDLWPLIAREVESVYYGALLDSRGRGEERDAFVEAYLAAADSAEVVHA
                     FGIAADDRWSWELLSQPYRDREFDSREDFQEWLLGYLAQDVAAAMQGNLTGPLKAALDV
                     LRDLRNEIRLAVDHGGLYGDSHRDELEGWYTPLNAFLSIGPPASRIEQMIALIEAGVLE
                     LTGPQTEIRIDTESGAFVAHSSVVPGPVVRSTVLIEARLQEPDLRRTADPLLRALLESA
                     QAATFRIATSEGSYETGGLAVTERPYRILDAQGAPHPRRFAYGVPTESVHWVTAAGIRP
                     GVDSVTLGDSDSIARAVLALPVVDRGEAAESAATAAEGAGVIV"
ORIGIN
        1 actctcctgt ccgtcagcga cagtggcgac ctcggccacg tcgtagaagc cctggccgtc
       61 cagccagcgc agcgtaccga ggtcgcgcag cagcacctcg tccacctcgt gggccagtga
      121 caccgccagc gggtaggtcg agtcgtccac cgtcggggcg atcgagccgc cgggttcgac
      181 catcatgtgc agctcgcgga agctctccag ggcccggacc tcctccagcc cgcggtagcc
      241 gcgcaggatg ccccgggccg gcgacaccat gccggcccag gccacgctcc ggctcatcag
      301 gtagtcctcc tgatggcgct ccaggaagcg ttcgggacgg gtgaaagcgt cgacggtcca
      361 gctgatctgc gactcgccgg tggcactgtg cgtgtagccg ggcaggtcga gccccgagat
      421 ccgggcgccc acctcgatga tgcacggacc ttgcggggtc agcttgatct ccacgtgggc
      481 cgggccgtgc gcgatgccga gtgcgtcgag gacctggaga ccgtagtcga cgatctgctc
      541 ctgcacctcg ccccggcgcg gcagcagttg acaggcgacg gccaggtcgc gcttgccgtt
      601 ggcgctgatc cgatgggtct tccagatgtc gcagacgtgg tggcggccgt cccggctgac
      661 cgtgttcagc aggtactcgg cgccgaccag gtactcctgc gccaccacgc cgtcaccggc
      721 ctccgagaag atgttctcgc ggcccgcgag ggtgcgcaag gcccgcaccg actcctcggg
      781 ggtgtcgcac cagaacacgc cgtcgttggc cgcgctgcgc agcggcttga ggatcgcccg
      841 gccgcccagc cgctggtgcc aatcgcgcag ttggtcctcg tcgcggacca ggatctgctc
      901 ggctccgcgg agcccgctcg ccttgatccg ttcgaccatg gcgtacttgt cgcgccgcgc
      961 ccggctcagc gcggtgccgt tggtcgggat cggctgacgg gtggacagct gctcgctcaa
     1021 cgcgtcggcg agctccacgc cgagctcgcc gccggccagc accgccagcg gttcgaacgg
     1081 ctccaactgc gcggcggtgg ccgcgatgtc gccgtggtgc accaggtcgg ccagataggg
     1141 attggggtcc ggctttccgg cgtagagccg gggcacctcg gtggtgctct ggactcggac
     1201 cggctcgatc ccgtcctcga tgaaggcggc cgcgagtcgg cgtgacaggg cataggtatc
     1261 gacgagaacc acacgccggg tagccaattg actgggcctc tctagcagct ggcgatctgg
     1321 gggagcgagg gcggtcgaca ggtagcgcag taggaggccg tcgactgaac tcgacggcct
     1381 tgccctgccg gagaattgcg ccggtgaacg gcgcctgaag cgccgtgaaa ttcccccagt
     1441 actgcggcgg tcgacagcga atgcctgacc ggcaatggga tctcaacaca cccccgtgga
     1501 cctgtcaaca gcgctccggt cagcaaggtt gtcttgccag ggactcttca aaaaacctcg
     1561 aacagcttgt acggtggaag tgaaagcgca cgtccggacc gcgtactgag gctccttctc
     1621 gaggggttct ccggcgttgt caccaactcc cttacgccgt accggggtgc cgccgaatcg
     1681 ggggatcggg gtttcggaaa tcagcgggcg cgcgaaagat ttgatgtacc gtcagttcgg
     1741 cggtctgcca cggagcttct ggatcgtctt cgccggccag ttcgtgaacc ggatcggcag
     1801 catggcggtg ccatttctgg tgctctatct ggggaaccaa ggcctttccg cctcggacgc
     1861 ggggaccgtg ctcgccgcgg tgggcctcgg cggactggtt tcgcagccga tgggcggcgt
     1921 gctggccgac cgtttcgggc cgcgcatcgc cctggtggca gggttgtcgg ccagtgccgt
     1981 gagcatcgtg ctcctgggcg ctgcccgcgg tctgccgacc gtcctcgcgg ccgccgtgct
     2041 ggtcggcgcg gtggctgaca tctaccggcc ggccgcggcc gccctggtgg ccgccgtggt
     2101 gcccgcgcaa tcgcgcccac gggcctacag cctgatctac tgggcggtga acctgggggt
     2161 cgggctcgcc gggctgctcg cgggtctgct cgccacctac ggctacggct tgctcttcct
     2221 ggtccaggca gccgcggccg cggccttcgc gctgttggtc gccatcctgg tgcccgggcg
     2281 gtccgcgacg gggtggtccc cgcctgcgac ctcgcggtcc acgaccgtcg ggctgttgcg
     2341 ggatcggctg ttgctggcgc tgatcgggct caacatcgtc agcggcctga tcaatgctca
     2401 gatcactgtc gggctgccgc tggcgatcaa gaacagcggt ctgtcctcgg tggtctacgg
     2461 cgcggtgttc atggtcagcg gcctgctcat cggtgtactg cagccgctgc tcgccggctg
     2521 gctcgagcgg ttcgaccgga tcgtggtgct ctccgtctcc tgggccgtct tcggcctcgg
     2581 cgtcgcggcc accggtctgg cgcgcaccgc gccggagtac ctggcaaccg tggtcgtgtg
     2641 gactctcggc gagatcggtg cggccagctt cgtcggcgcg atcatcgcgg acctggcccc
     2701 cgcgcacgct cagggccgct atcaggcagc cttcggctgg tcctacgcgg ccgcccaact
     2761 gctcggcccg ctcggcggcg cctatctgta cggatcggtc gcgccctggg ccctgtggtg
     2821 gtcctgcggg ctgctcgccg tcctcggcgc ggccggtggc ctggcgctgg tggctccggt
     2881 ccgacgccgg agcgctgcgc ccgcttccac cccacttctg gagaacgcac tgtgactcaa
     2941 gccatgcgca accacggctc gtacccaccg acctcgaccg cgatcgacct gctggagctc
     3001 taccggcgga tgcgggtgct gcgccggatg gacgaggtgc tcgccgagtt ggtggccgac
     3061 aagctggtca ccgggccgat gcacctcggg atcggccagg aggcgaccgg gatcggtgcc
     3121 accgcggcgc tgcggcccgg cgacctggtc accgccacgc accgcccgca cgcccagtac
     3181 gtgggcctcg gtctgtcgtt gggacgcacc ttcgcggaga tgatgggccg ggcggacgga
     3241 cagtgcggcg gccgggccgg gcacatgctg atcgcggacc aggagcgcgg cctcctcggc
     3301 ccgtccggga tcgtcgggca ctccctgctg ctggcggtgg gccacggctt cgcccagcgg
     3361 cgggccgggc agggcgccgt cacgctctgc gtgaccggtg acggtgcggt caactccggt
     3421 gccttcaacg aggcgttgaa catgatggcg ctgtggcagc tgccggtcgt ggtcctggtg
     3481 gagaacaacg gctacggcct gagcgtgcgc ctggaccggc actcccgcga gaccgagctg
     3541 tacaagcggg cggccggcta cggagtaccc ggagtactgg tggacgggaa cgacgtcgag
     3601 gcggtgcgcg acgtggtctc ggcggccgcc gaacgggccc gtgccgcgca ggggccgacc
     3661 ctggtggagg cgctgacctt ccgcaacacc ggcttctcca gctccgaccg cggcggctac
     3721 caggacccgg gcgagggcgc ggagttcacc gatccgctgg aactcgcggc ccggcgtctg
     3781 gtggccggcg gcaccacggc ggcgcgactg gccgaggtgg accagcgcgc ggcccaggag
     3841 gtcgaggagg cggtggtgtt cgccaaggcg agcccgtggc cggatccggc ggagctgttc
     3901 gagtacgcgg ccaagtggga ccagggagcg ctgctgtgac ggggacgacg accgccagga
     3961 tgacgtacgc gcaggcgctg aacgacgcgc tgcgcctcga gatgctggcc gacgatcggg
     4021 tggtcgtgct cggtgaggac gtcggccgct acggcggcgt cttctcggtg acccggggcc
     4081 tgatggacga gttcggcgcc gaccgggtgc tggacacgcc gatctccgag aacgggatcg
     4141 tcggcgcggc gatgggcatg gcgatgagcg gcctgcggcc ggtggtcgag atcatgtaca
     4201 ccgacttcct ctgcctggcc ttggacagca tcgccaacgg cgtcgcagcc ttcccgttcg
     4261 cctacaacgg gcaggtgacc atgccggtgg tggtgcgcac ccagggcgga gccgggatca
     4321 acgccggtcc tcagcactcg aagtccctgg aggcctggac cgcccacctg cccggtctgc
     4381 acaccgtgct cccgagcaac ccggcggacg ccaagggcct gctgaccgcg gcgctgcgct
     4441 ccgacgaacc ggtgatcctg gtggagcaca agctgctcta ctcgaccgag ggcgaggtcc
     4501 cgtcggggga gcacctggtg cccctgggga cggcccaggt ggtccgcccc ggcactgacg
     4561 cgaccgtgct cgcgctgtcc cggatggtgc ccgaggcact ggtggcggcg gcccggctcg
     4621 ccgagcaggg cctggactgc gaagtggtcg acgtgcgatc gctgcgaccg ctggacgtgg
     4681 ccacgctggc cgcctccgcg cgccggaccg gacgcgtggt cgtcgcggca gaggcgtggg
     4741 tccggtacgg accgtcggcg gagatcgcgg cggccgtgac cgagagcgcg ttcgacgacc
     4801 tgcgtgcacc cgtggtccgg ctgggctcgc tcggcgttcc ctaccccgcg agtcccgcac
     4861 tggagcaggc cgtgctgccc gacgccgcgg cgatccagca ggcggtcgag cagctggtca
     4921 aacgcactcc ctgagcgcac cggctgaggc agtagcagac caacacccat ggaacggagc
     4981 acccaggtgc gctttctcga caagtccgtc ctggtgaccg gtggcggcac cgggatcggc
     5041 cggacgaccg cgctggcatt cgcggcggcc ggcgcccggg tcaccgtttc cggtcggcgg
     5101 cccgagccgc tggccgagac ggtggcgctg atcgaggccg ccggcggctc cgccgtcgcg
     5161 ctgccggccg acatcaccga ggagtccgaa gtcgccgcgc tggtcgagca ggtgatcgcc
     5221 cgtcacggcc gtttggacgt cgcctgcaac aacgccggcg tgcccggatc ggggcgccgg
     5281 ctccacgagt tcggcctcgc ggactggcgc cggatcaccg acaccaacct gcagggcgtc
     5341 tggctctcga tgaagtacga gatccaggcc atgcttcagc aggagggcgg cggagcggtg
     5401 gtgaatgtgg cctcgatcgc cggcctggtg ggatacctgg acgcggctcc gtacaccgcg
     5461 gccaagcacg gcgtggtcgg gctgacccga agcagtgcga tcgactacgg gcccaaggga
     5521 gttcgggtca atgcggtctg tcccgggccg gtcttgacgc cgatgctgga acaggcccgt
     5581 cgtgaccggg gcccgagcgc cgacgagttc tatctgcgca acatcccgtt gggacggctg
     5641 tgccgacccg aggaggtcgc ctcggccatc ctgtggctct cctcggacga ggcctcctac
     5701 atcaccgggc aggcgctggg tgtcgacggc ggctggaccg cgcactgatc cggatcatgg
     5761 ggcggcctcc ggccgggcgg ccgccccatg atggggtgtc agttcctggc gaacgcccgg
     5821 cgcagcgcgg cgctctgctc ggccagcgcc cgcaccgaga gccccgcatg cggaaccgcg
     5881 gcatcgaagc tgtggaaccc gcccgcgaag tggtggagtt cgaccgagac gccgtcctcc
     5941 agcatccggg ccgcgtacgc gatgccctcg tcgcgcagcg cgtccacctc ggcgaccagg
     6001 acgtaggcgg gggcgacacc ggtgaagtcg acccgtcgag cggggaccgc gtacgggtcc
     6061 tcggtcccga aggcggggcc caggtagtgc cgccacatgt ggtggctgtc ctcgatgtgc
     6121 caggccgcgg tccgcgggta gcggcgcatc gagtcggagt ccaagcggtc gtccagggcg
     6181 gggaagagca ggagttgcag caccagttcg gggccctggc ggtcccggca catcagtgcg
     6241 gtggcggccg ccagggtgcc gccggcgctg ctgccgccga tcgcgatccg cccggcgtcc
     6301 aggctcagcg actcggcctc ggcggcgacc cagcggaccg ccgcgtagca gtcctcggtc
     6361 ggtgccggga acgggttctc gggcggtcgg cggtattcga ccgagacgat ggcgcagtcc
     6421 gtgtccaacg cgagtgcgag caggcggtcg tgctcggtct cgaggtctcc ggcgacgaat
     6481 gctccgccgt ggaaatagat caggaccggc gccgactcct ggagcccgtc cgggcggtag
     6541 atccgcaccg gtatccgccg gccgtcctcg gggacggtga agctggtgtc ctcggtccgt
     6601 accgaggcct cggcgggagc ctttccgcgg agcgctcggg agatcttgac ggatctggcg
     6661 aaattgcgcc gcgatccgag cgggtcggcg aaagccacat agggctggag ctgggctgcc
     6721 ctggccagtt cggaatccag ccggtccgca tttccggtat tcaacgtcat ggtcaagact
     6781 ctaccggctg agcgacttgt tcaggcagac cggccgacaa accggccgcc cgccgatgat
     6841 ccggttccgg acctgaggtc gggcgacgag gctcatgcac gtagcgtagt gaccatggtc
     6901 cagtaggtcc gattttgtcg agtttgacgg ctcgtcagga ctggacggac tggtcgcgtc
     6961 tcaccctccg tgggttcaac tggcccaaaa tatacggaga ctgacgatcc acatacctat
     7021 tgacaggctc acggtcggct gactacggtg ctattggcaa tgaggcgagc catcgcgggg
     7081 ggcggtcgtt cggattgttc atccctttgc cattcgcgca tcgctcagtc gaatccaagc
     7141 agctttatcg gcgccttacc cataggctcc gaagcgagct gctttctcgt atgcctaccg
     7201 gcaaccagac gtttgggact gactcaccat gggaactaca gcccagctca ccatagatac
     7261 tcttcttgtc ctcggattcg gagtccagca ttccgtgctg gcgactctgc gagtcaagcg
     7321 cgtggtcaag gcgaaaaccg gaatggaggc gctggcctgg cgttccgtcg agtcgctttc
     7381 caacgtgctc tacatcctct gcgccggcgc gctctggcag cacaccagca acgtggtgtg
     7441 gcacctgagc ggcgtgccga tggtcgtgat gctcgtcctc gcagtcgccc actggctgtg
     7501 gtactggcag ctgcacctgt tcgagtacga ctgcggactg gccttcggat cgaccaccct
     7561 ggtggcgcag atcgccggcg cccagggccc gaagctgatc tcctggaagg tcggcagccg
     7621 ccgctggatc cgcttcccgg tgcacaccgc gttcttcggc atgttcttct gcctgccgac
     7681 catgacgacc gacctgctcc tgctggccgt ggtcctcaac atctacaacg tgatcggcag
     7741 catcctctac gacaagcgcc tgatcacgct ggcgggcgac gcctaccgtc cctacctgga
     7801 cgtgaccggt ctgatctggc cgcccgtcta ccggatgccg cgcggtgccg ccgacctgga
     7861 gatgcccgcc ccgcagcact ggcgcaagcc gctcatgcac ctgcccggcc tggtcgtcgg
     7921 aatcggcctc ggtgtgctct accacttcct gatcggcgcc aaggcggaca ccccgatcga
     7981 gatggccaag gccggcggcg ccggtctgct ggcggccgtg ctctccggcc tggtgatcgg
     8041 cacgatcagc aagcccgagg ccaaggactg gggtcagcag cagaccgacc tctccaccac
     8101 ggtcgccctc tccgccgcca tcggcgtggt cacctgggcc accatcggct gggtccagac
     8161 cggttcggcc ccggcgttca ccgccttcct gccgctctgg ttcaccgtgc agtacctcgg
     8221 ccacgtcttc gcgttcctcg ccaaccgcaa gaagtggtcg gtgagcctga tcccggtcga
     8281 gaccaccgcg gccaccgccg cgcagcctgc caagtctgcc tccgtcccgg tcgcggctgc
     8341 cgtcgctgag ccccggagcg tctgatgtcc ctgcgcacca cccctgcgcc cgcggctcgg
     8401 accgaagtgc tcgacattcc ggtgcgggtt cccgcgaccc ggaccccgta ctggcacacc
     8461 gacagcccac tgctggcggt cacccacgtg gacccgcagt acgcgcggct gcgggagttg
     8521 ttccccgagg gctgggtgca cctggcccag gcgaagtccc tgatcgacgg cgtggccgca
     8581 ctggaggttc cggaggtcgt cccggccgcc gtgcacctgc ggcgggtcgc cccgctgctc
     8641 accgcggccg cccacgagct gatccagttc gcggagaccg agcaggtcgg cgccgccgcc
     8701 ccggcggccg agcaggcccg caccgcggcg gaccggctgc tgcactacgc ccacacccag
     8761 gtgtggaagg agatcatcct cagcgagccg gtgccgggca cgccgtggct ctactgcggg
     8821 ccgctcaaca cctgggccat gaacacggtc aacctgccga tcggcatgct ggtcgtcacc
     8881 cccaacgcct cgctgcagca ggagatcgag gccgtgaacg tgctgctgcc cggcatccag
     8941 ccggtcatcg gcggggtgct gggcggcgcg gcgaagtcca tccagccgga gcacccgacg
     9001 atgcagatcg tcgacctgct gctggccggt ggcgagtccc gggtcggcca caagaacttc
     9061 gcccacttct tcccgttgga ggcaccgcac tcccgggtgg aggggcccga gttcaccgtg
     9121 gtcttcgcca acgtgcacgc cgaccggttg gagcgctgct cgctcaacct cctggaccgc
     9181 taccaggagg cgggtgaggc caccgacctg caggagacgt tgcgggcctc gctgcgctgg
     9241 ttccgctgcc acgacctcgc gcacttctgg cggcggacgg ccgtcgaggg gaacgggagc
     9301 ccggcgccgg gcctcacccc gttcgaggcg atgacgttgg aggagaccta cgccgacgtg
     9361 ttgggcctgg tctccgcagc ctcgttcttc ccgggcacct cactcggaca ggcctacctc
     9421 gccgagctgc tgcgctacct gtcgcgccgc caccaccact tcgcggacag cggcgcggcg
     9481 atgctcacgg ccggctggct ggtcgccaag ggcgtctcgc tgcagaaccg cgacgaccac
     9541 tggctcgaca aggcgctgcc gctgctcgag gagttggccg tttgcctgca ccgcgcgctg
     9601 tgggaagctg actcgaccga cctcgacgag ctgcgcgacg cgcttgccat cggtacccgg
     9661 taccgcgacg ggctcgccga gctgtaccag accatcccga ccgacctcga atacaccttc
     9721 ggctaaggga atcatgcaca accgcactgt catcatctcc ggggcttcct cgggcatcgg
     9781 cctggccacc gcgcggcgct tcgccgccgc cggtgacacg gtcgtgaact tcgacctcca
     9841 gcccccggct cccgaggacg cggtgggcga gtgggtccag gtcgacgtga ccgacttcgc
     9901 ccaggtcgcc gccgcggtcg acaccgtggc ggcgacgcac ggcggcatcg gcgtcgccat
     9961 cgccaacgcc ggtatcagcc tgcgccgcac cttcctggag atgaccgaga aggacatccg
    10021 caagctgctg gacatcaacc tgatgggcgt catcgcgctc tggcaggctg ccgcccgcca
    10081 catggtggag gccaaggagg gcgtcctgct cgcgaccgcg tcgaccaacg gcaccgccgg
    10141 ctacccctac tacgccgact acaacgcctc caaggcggcc gtgctcgcgc tgtcccgctc
    10201 gctggccctg gagctctcgc cctacgtgcg caccgcctgc gtcagccccg gctacgtcat
    10261 gacgccgatg cagcgggccg agtacaccga cgagatgctg gccgaggtga acgagcggat
    10321 cccggccaag cgccacgccg acccggccga gatcggcgag gcgttcttct tcctcgcctc
    10381 gccgcaggcc aagttcatca ccgggcagca actgatcgtc gacggcggcg agctggccgg
    10441 cggcaccgcc tcggcccacg gcgtcgtctt cgccgccacc caggactcgg aagggaacac
    10501 ctccgcatga ccatcaccca ggagcagccc gccaccctgc ccgccgtcgc cgacgtcctc
    10561 ggtgcggccg ccgagcgctg cgagacggtc gacctgggcg ccggcctcac cgccttcgtg
    10621 atcagccgcc cgggacgggt gctgaacctg tcggaccagg agcggatcta ccaggccctg
    10681 atcccggtga ccacgagcag cttcggtgcg gacatgaccc cgtactggac gcagcggagc
    10741 aaggagggat acctggagcg gctggccgaa ttcgtgctga tctcggactc cgagggcacg
    10801 atggtcggct ggaccggttt ccacatcctg ccgtacgaca ccttcaccct ggtctacctg
    10861 gactcgaccg ggatggtgcc gacccgccag tccggtggcg tgatgcgggc gttgatgcgg
    10921 cgtcaggtgg tcgactcggg gctggccgac tgtccggcgg accgcccggt ctacctgacg
    10981 gcgcgcagcg agagcccgat cttctaccgg ctcatgcgca agctgctgga ctccggcgag
    11041 ctctacccgc acccgcacca gccggcgccc gaggacgtgg tcgaggcagc ccggcacctg
    11101 gcgaagtggc tgggccagga ggacatcctg gacgcgccca gtctgaccgt gcgcggcgcc
    11161 taccaggcgc tggacgagct gtacggggag ctgccgacca ccggcgacgc cgacctggac
    11221 aagctcttcc gcggtcagct cggcccgctg gacgcgttcc tgctggtcgg ccgcgcccgc
    11281 tgaggcccac tcggccaagg agtctcatgc gtctcaccct gatccaggcg gagaccgacc
    11341 gaacgctgcc gttcgagcag cggatcgccg tggcatgcga gcagatcgcc gcatgccacg
    11401 gcgcggacct ggtcgtcctg cccgaactgt gggccaccgg ctacttccac ttcgacgact
    11461 acgccgccac ggcccagccc cgctcgggcg aggccgcccg ggcactggcc gcggccgctc
    11521 gcgcggccgg cgtccacctg cacgcgggca gcctggtgga gcgggacgag caggggcggc
    11581 tctacaacac cagcctgctg tacgggccgg acggcgaact gctgcacgcc taccggaaga
    11641 tccacctctt cgggtacgac tcccgggagt cggcgctgct gaccgcaggc caaggcgccg
    11701 ctgtggtgcc caccccgttc ggccggatcg gcctggccgc ctgctacgac ctgcggttcc
    11761 cggagctctt ccgggcgcag accgagcagg gagccgagct gctgctgctc tcggccgcct
    11821 ggccgctcgc ccggatcgag cactggcagc tgctgctgcg ggcccgggcg atcgagaacc
    11881 aggccatggt ggtcgcggtc aacgcgggcg gccgccaggg ggaggtggag ctcggcggtc
    11941 acagcatggt ggtcgacgcc tcgggccagg tcctgctgca gaccggctcc gaccccgaga
    12001 tccgctccgt cgacctggac ctcaccagca ccgcgcaggc ccgccgcacc tttcccgccc
    12061 tcgccgaccg acggccgccg agcgctctcg aagctgtgcc agaaatctga cgccgcgcca
    12121 catcaccgaa caggcaccga ccttgaccct cattgttccc gatggaatcg accccgaact
    12181 cgccaggtcg gcgggcctcc agccggatct ggacttcgcc gacccgccgc acgtccgcgc
    12241 ttcgctgaac cgggcgttca agttctccaa ggccatgcgc ccggcgccgt ccgcactgga
    12301 cgggctcacc acgaccgacc gccacgtgcc ggcccgcgaa ggctctcccg acatcccggt
    12361 ccgggtctac gacgccgccg accgccctgc ggcctccgcg gccctggtct tcttccacgg
    12421 tggcgcgttc gtcgccggag acctggagac cgaggacgcc cgctgcgccg agatcgcccg
    12481 ccgcaccggc gcgctggtgg tctccgtcga ctaccggctc gccccggaac acccgttccc
    12541 ggccggcttc caggactgct acgacgtcct ggtctgggtg gccgaccagg ctgccgaact
    12601 cggcgtggac ccgaaccgga tcgcggtcgg cggcagcagc gccggcggcg cgctggcagc
    12661 ggcggtgtca ctggcggccc gcgacctggg cggcccgcgc atcatgctgc agatgctgct
    12721 ctacccggtg atcgacgacg cgctggacac caggtcgatg aaggagttcg acacgacccc
    12781 gggctggaac cagcccaaca gcgtgcacat gtggaaccac tacctcggga ccggggaccg
    12841 cggcgaggtc tcgccgtacg ccgccccgtg gcgggccacg gacctgtccg ggctgccccc
    12901 ggcctacgtc atgacggccg agttcgaccc gctgcgcgac gaggggatcc ggttcgccgt
    12961 ccggctgctc gccgccgacg tgccgaccga gctgcaccag ttccccggcg ccttccacgg
    13021 cttcgacgcg gccgcccccg aggcgacgct gacccgccgc tcgctcgacg agcagtgcgc
    13081 ggtgctgctg cgagcagccg ccatgagtgt ggagcccgcc ccggccgacg cctgacgcac
    13141 ggtcggacac agcacagtgg cccgccgccc cggtctcccg gggcggcggg ccaccgcacg
    13201 tgctgtcacg cctcggcgcg cgccttcgcg atggccgagg cgataccgcg cacggtcagg
    13261 tccgccagta cctcctcggc ctccaggtag acctcgaact gctcctcgat ctccgagagc
    13321 atcgcgatga tcagcagcga gtcgccgccc agctcgatga acgacacgtc gtgtgcgacg
    13381 tcctcgcggt gcagcaacct gccccacagc tgtgcgacct cgtccaccgg tactgccagg
    13441 gagggcgtct gtccctcggt catgtcaggt gttcccctcg tgcgaaccgg ccctggtcgg
    13501 gccgggtgga tcggatccgg atcggtggat cggatcgggg tcccgggcct cgggttcgag
    13561 gcccgggaca gtcctacagt ggtgccaggc ggtcggccac cgcggtcctg accgcttccc
    13621 ggttgatctt caggttccgg ttgagcagcg ggctctccgg cgtcagcgcg ccctccagca
    13681 gtgccaggtg gcggatctgc agatctgttc cgagccggga gttgatctgg gtgatggccc
    13741 ccagcacggc ggcccgggtc tgctcctcgg agccctcgta gaaggcggcg gcggccagca
    13801 ccccggtctc gacctggaac agtgccgcct ggtgcacact gctcggccgg cacagctcgg
    13861 cctccagatc ctcggtctgg atcttctggc cgccggtggt gatgatgatg ttcttcttcc
    13921 ggcccttcag gtgcaggtag ccgtcggcgt cgaactcgcc gatgtccccg gtggcgatgg
    13981 tgtcggcggc acggaagacc agggcggtgt cctcgggcga ctcgccctcg tagccgacac
    14041 acaggtgcca ctggtgctgg accagcacct cgccgtcctc gccgatccgc accgtgcccg
    14101 ggtacacctc ggtgcccacc gagcccagcc ggttgccttc gcgccggttc caggtgaggt
    14161 acccgatctc ggtcatgccg tagatctggt agagctcgaa tccggcgtgg gtgaagaact
    14221 ccagcatgcc gggacggacc ggtgcggagc cgaccagcat caggcgcagc gagccgccgt
    14281 acatgtcgtg gaactcgcgg aacaccgagc gccgcagctc gcgtgcctgc gcatcgggca
    14341 gttgctccgc cgaggcggcg gccgcgtcca accgggcgcg cttgtccggg tccaggttgc
    14401 ggtagcgctt ctcgacgaac tcgtagaagt tcggcgggcc gagcatgatg gtgggcttgg
    14461 tcagcggcag cgtcggcagc atccgcgccg ccgtcgtcat gatgacctcg cagccgttgc
    14521 ggatggcgag gtagcacagg taccgctgct ggaaggtgga cagcggcagc gcgatcatga
    14581 tgcggtcctc gggcccgcag gggtaggccg cgctctgcgc ctcgaccagg gcctgcaccc
    14641 cgggccaggc gagcagcagg cacttgaccc ggccggccgt ccccgaggag aaggccaggg
    14701 tgaacacctc gcggtcgctc acccggacct gctcgccctc cggggccggc ggatcggcga
    14761 ccggctcgac ggccggctcg gtcaggacct gttccagcgc gccgacttcg gggccgtccg
    14821 tgccggagcg gctctccttc ccggcgaaca tcgccgccag gccgtagcgg gcggccacct
    14881 gtgcgttcga cgtccccttg aagtccggca ccgggaccgc caccgggacg gcgcccaggt
    14941 gcagcagggc cagatcgagg gcgagccact cgtaggagtt gtggcctcgg atgccgatcc
    15001 ggtcgccggg gccgacgccc cgccgggcga gcccggcggc gagcgcttcg acgtcctggt
    15061 ggacctggct ccacgggacg agccgggtct cgccccgctc gacgaggcgg acaccgccgg
    15121 tgcgggcggc gcgcagccag tccatcagta cgccggggcg cgggtcgtcg acggcttcgg
    15181 tcgaggcgga cgggtggtca gtacgcacag tgggactccc gggtgacggc cacgcggtgc
    15241 cgttctggcg gaatcgaagg gaaggggttg gtcatgtcag gcactggccg aggccgaccg
    15301 cgccgccaag cggtgcgcgg accgcccggc cacggcgatc ccggcgcagg cgaggacgcc
    15361 gacgaccagg caggccgccc acagggcccc ggtggaccgg ccgtagacga agatgccgat
    15421 ggcgggcccc agggcgaagg ccaccgcctg gacggtggcc agatagccct ggtagcggcc
    15481 gatccggtcg gcgggcgaga gcgcggccgt ggcgctgctg acaacgggcg agaagagcat
    15541 ctcgccggcc gaccagacga ccacgccgag ggcgatcagg aggtaggagt gcagcgcccc
    15601 gcacatggcg atgccgatcg ccatcgcggc ggtgcccagc gccatcggga cccaccaggg
    15661 caggcgcctg gtccaggcgc tcagcggcat ctcggcgatg atgaccagga caccgttgag
    15721 ggtcagcagc gaggcgtagg cactggcgct gtgcgcggcg ctgaccgcca gtgagaccgt
    15781 cgaggagtac tggacgtaca ccacggtgat gccgagcacc gccccgaaga aggcgagcag
    15841 gcccagcggg gtgtgcccgg tccggtcctg gtcggccgcc ggccccgcct cggcgtcggt
    15901 cggcttcgcc gaggggtggc gaagcccgaa ccagagcacg gcggcgaaga ccgcgtagca
    15961 gcacgcgctg gccaggaaga ggcccttgag accgtggggc gcgatgaaga cggcgatcac
    16021 cgggccgagc gccgcaccga ggttcagcgc cagccggaag aacgcgaagg tcggcacccg
    16081 gtcccgttcg cgggtgttgt ccaccagcag cgcggacgcg gcgggcaggt acgcctgcgc
    16141 gaacagggcg gcgaggaaca cgccgaccag ggccgtgttc cggttggggg agaggccgat
    16201 caccgccagc ccgccgctgg cgagcagggt cgaggagacc agggcgatcc gccgggagaa
    16261 gcggtccgcg gcccagccgc ccaacagcga gccgatcggg gtggccgcac cgacgaagag
    16321 cagcacgatc ggcatctgcg tgagcgagaa gccgagttgt cgcaggaaga gcaccaggaa
    16381 ggtggagaag aacgaaccgg tgcgattgag gaacaccccg gccaccagga ccttgaccgg
    16441 tcgcggagac ttcagcacca cctggaggat cgagcggtcc ggggcctgcg accgctcggc
    16501 gtcggtgtcc gtgctcatcg ggcgcccagc ggcgtacctt cgacgaccac gtcggcccgc
    16561 acggctgcga gccttgcctg acagtccggg cggctctccg cggtgacgat cgcgatcgcg
    16621 atgcgggaga ggaacccctc cggcggcaac ttgacctcgg tgccggccgg tacgaacgtg
    16681 gtgaactgtt ccaggcccgg gtgctcggcc tcgccgcgca gcgccacgga ctccagccgg
    16741 atgtcctgct cggggtagat catgccgatc gccgcgtgca ccgagcggtc cgtcgacagg
    16801 tccggctcca gacccaccgc cacactggcg gcggcacccg ccacatcgac tccgctggag
    16861 aggtgaccga ggtaggggat caggtcgccg ccgagccgta cgttgatctc cacgatccgc
    16921 ggtccgcggc tggtcagctt gaactcgctg tggctgacca ggcggtccag cccgaccacc
    16981 gcgtgtgcct ggaccaccat gtcgatggcg gccgccaggt ccgggtgctc cgccgccggg
    17041 acgatgtggc cggtctcctc gaagtacggc gggaagccga tctccttctc cgcgacgacc
    17101 agcggcgtgg tgcggccctc ccaggtcacg cagtcgacgc tgtactcggg gccgtcgagg
    17161 tactcctcga tcaggacacc gctgtgggcg gaggcggtgc cgtcgggagc ctgcgcgtcg
    17221 gctgcgaccg tgaaggcggt cagcagctcc ttctcgtcct ggacccggac gacgccgatg
    17281 ctcccgccga gggcgcgcgg cttgagcacg accggatagc cgatctcatc ggcggcgcgt
    17341 atcgcctcct gctcggtcag ggccaccgcg aaccggaccg ggctcacgcc ggcctcggag
    17401 agcagggcgc gcagggcgct cttgtccttg cagtggcgga ccgcctcggc gtcggtgtac
    17461 ggcagtccca ccgaggcggc cagcctggcc accggctcga ccagcagctc gtcgtaggtg
    17521 agcagcccgt ccggcgcgac cttgcggacc agggcctcca gcacctccgg atcgtaggag
    17581 ccgaccacat gagactctgt cacatacggc tgctgccacg atatttcgga atcactggcg
    17641 aggatgatgt cgacccgcct gctcattgcc gccagagcat attcacggaa tggcttcccg
    17701 ccactgccga taacaaggag gcgccggttc ggcatgtgag agctctccac tcgtggatcg
    17761 gtggttctgt cgcggtcatg ctaaaggctg tcacatcagc cagtcaacga tcccagcaaa
    17821 atctgacatg ctgtcatctg gcttgtcagg gaagggcgct ggatgtgaaa ttcggcaccc
    17881 tggggcggcc gctttcaggc acggcggcac gacaaagcag cgctcctagg acagtgtcat
    17941 cggaccggtc aaaccgccag tggcgcagga ccgcacgtcc tgtgaagttc cggtccgtaa
    18001 gtcgccgtcg acccggcgat tcccccagtg ctgcgcgccc tccgacgtga tgcccgctca
    18061 ggcgtccgcc gggggtgcaa gtgcccctgc gaggactgta ccgtcgcagg tggacgggcg
    18121 ctaccggtcc tgcggatgtc gccggagccc tgtgcacacg aaaggcgcct gaaccgcccg
    18181 ttgcccggca ttccgagccc gcgcggcggt cggtgattct ctggccgcgc aacatgtcgc
    18241 taaggtccag ttccatgtct actgaatggt ccaccgcgtc gctcgatctt catctggaat
    18301 tggatctgag ccgacgccac ggacgggcgg acaggttggt ggcggcgatt cgcgaggcga
    18361 ttgatgccgg ccgactgctg cccggcggca agatgccgtc cactcgcagc atggcattgc
    18421 aactcgaggt cgcccgcggg acagtggcca gcgcctacga gcaactcgtg gtcgccgggt
    18481 acctggaggt cagtcacggc tcgggtaccc gggtggcacc gctgcggagc cggagcgagg
    18541 acgcccggac atcgagtgga ccggcggccg caggctcacc cgcgccgagc tggaacctgc
    18601 gcccggggct gccggacgtc acgctcttcc cacggacggc atgggtggcg gccacccaac
    18661 gggtgctccg cgaggccccg gcggaagccc tcgactacgg agacccgcgc ggccgacccg
    18721 agttgcgcct cgccctggcc aactacctgg ggcgggcccg gggtgtggtc gcccacccgg
    18781 accggatcgt ggtctgccac ggcttcaccc aggcgctcgg cctgctggcc aaggtgatcg
    18841 ccgaccggaa ggcgccgacc atgaccttcg aggatccgtc gtacccgctg ttccgggaga
    18901 tcgtccgcac cgccgggctg agcacgctga ccgccgaggt cgacgaccag gggctgcgtc
    18961 ccgagaccct cggcccgtcg agcgcggtgc tggtcacccc gatccaccag tacccgctcg
    19021 gcgcggagct ctccgcccgc cgccgccagg agctgatcgc ctgggcgcgc gaggccgacg
    19081 cggtcatcat cgaggacgac tacgacgggg agttccagtt ccaccgcaag ccgaccgggg
    19141 cgctgcaggc gctggacccc ggtcgggtcg tctacgccgg cacgaccagc aagacgctgg
    19201 cccccggcct tcggctctcc tggctggtgc tgccgcccga ctgggtcgag ccggtggcgg
    19261 tggccaagcg caacgccgat caacactcgg ccgcgctggg ccagatggtg ctggcccaac
    19321 tgatcacctc cggtgcttac gaccggcaca tccggcgctg ccgggcccag taccgggagc
    19381 ggcgcgcgcg gctcgccgaa gtgctggccg accacgtgcc ccaggtcgag ctcgtgggcc
    19441 cgagcgcggg tctgcacgcc ttggtccgat gggccgagga cgggcccagc gagcgcgaca
    19501 tgctgctcgc cgcgaagcgg gagtcgctcg ccctgagcac gctggggccc tactgggcaa
    19561 cgcccggtcc gcaccagccg ggtctggtgc tcggctacgc ctcgccgccg cagcacggct
    19621 acgcgggcgc cctggccgcc ctgaccaggg ccttcggcag ggtcttcgac caaggcaccc
    19681 ggaacacgcc ctagtccacc ctgatgtcga gcaacgcctc cacctcggcc gccagctgat
    19741 ggatcccgat cgggtgcccg gccggatccg gagtggacca gaccgacaga aggccgcaga
    19801 tgtcgaaccc ctcaggggcg tgcccgatcc ggtcgccggg agcggcgagc gcgtagtacg
    19861 cgcgaaagcc cggatggcgc caggcctcgc cgacctggtt ggccgcgacc gtgccggacc
    19921 ggtagacgaa tcggatgcag gtggccaggc gggccggagt gcggcgggcg gccgcggccc
    19981 gggcagcggc ggaccgacct gcggcggcca gcaggaaggc ctcgaccagg tcgatgcggt
    20041 gagcgtcccg gatgttgcgg tacacgtgac cgccgctgat ccgggtgctg aactcgacca
    20101 gccggaaacg cccttcggtg tccttgcgga actcggcgtt cagcaggcag gtctccagat
    20161 ccagcgacct gctcaaccgg cgcatcaccg cggtgagttc ctcctcggtg gcctggtcga
    20221 ccccgggcag ggtgtacagg tcctcctcga agaacggcgg cggactgagg accttcgagt
    20281 ggatcccgcc cagctggaac tcgccgtcga cgaccacccc gtcgcaggtg acctcctccc
    20341 cgggaaggaa ctcctccagg agcgcccagc tgtcgtcgag ctggtcgtag aagtggttct
    20401 gaccggaggc ggccagcgtc cggatctccg ccaggacccg tagcgcgccc gctgcgtccg
    20461 ccaccagctc cacgtgcgaa ctgctcgcgc cccgggtggg cttgacgaca caggggtagc
    20521 cgacctcggg caggcccgcg gtcagctgcc ggtcgccgat cgcccagtgg cccggcgtcg
    20581 gcagcccggc tgccgcgaag tgcgcccgct gccgcgcctt gtcacgcgcg gtcgcgtccg
    20641 ccacgggtcg ggaccagctc accccacggg cggcgttggc ctcgccgacg gcctcgatgt
    20701 cggtctcctg gaaggtgacc gcgaaggccg cgtcccgctg gtgcagcacg tccttgaccg
    20761 catcgagcag cgcgccggtg gcgctgcccg acggcagcag ccgcaccgag gcgtagcggg
    20821 ggtcctgctg ggcgccggcg tcctcggtga ccaggtgaac ggccaggccg agccggaaca
    20881 tcgtctcgac atggtcgtgg cgggtcagca ggccctggcg catcgccaac acgacgtcca
    20941 gtccgtccag cgggggcagc tcactcattc gtctcacctc gggtggttcc gatcaacagg
    21001 atggccagcg ccaggaccgc ggcgagggcg agcaccccga tccagaagcc gtggcgagcc
    21061 tcgttccaga gcgcgacccc gaccgccggg ccgatcgtga agccggcggt ctgggcaacg
    21121 gccagcaagc cttggtagcg ggcgagttgg ctctgcgggg cgagcgccgc gacggcggcg
    21181 ttcgcgaccg gcgcgaagat catctcgccg acggtgaaca gcacgatccc gccgatgatg
    21241 gcccagctct ggcgcagcag gccggccagc accagccccg tcgccatcac caggacccct
    21301 ccggccagcg ggacgcgcca tggagcccgt cgggtgacgg agctgatcgg cagttccccg
    21361 ccgagcacga cgaagccgtt gacggagagc agcatcgcgt agaaggccgc tgactgcccg
    21421 tcggcggtga gctgcagcgg cagggcggag aggtgcaggg cgtacaccgc ggcgaccacg
    21481 aagagcaggc cgcacaggat gcgcacctgg cccgtccgag cccgctcggc cgcgccggcg
    21541 cgatcgtctg gcgcgggttc gtcctgctgc tgcgggccgt ccgagccgga ccggctgcgg
    21601 gctccccact gcaacaccgc cgcgcagagc gcacaggtcg cggcattgac cgcgaacagc
    21661 gtggtgaagg agtgcagggc gagcaggccg gccagcagcg ggcccacggc actgcccagg
    21721 ttcagcgcca gccggaacag cgcgaagatc ggcacccggt cctcgggact gctgtgcgcc
    21781 gcgagcagag tgctcgcggc cggcacgtag gcctgggagg tggtcgagac caggcagacc
    21841 gccaggccga cggtgaggtg ctggtgagcc tgcgagagca gcacgagcga ggccgaggag
    21901 gccgccatcg agagcacgat cacccgatgg ttcccgtacc gccccgcgag caccccgccg
    21961 gcccaggaac cgatcatgct cgccgccgcg atcgccgtca gcgcgtaggt gagcagtgcg
    22021 ccggagaagc cacggctctg caggaagagc gtcgcgaagg tggcgaagaa cgatccgagg
    22081 cggttcacga agacgcccgt gaccaggagc ttgacgggcc gtggggcatg ccggaccacc
    22141 gtggccacgg acctgcgcgg cgaggtgccg ggtgccgcgt cggtgagagc cgtcactgct
    22201 cgaccgcccg gacggcgccg gtcaccgggc agctcagcac ggtgtcctgg ctgacgaagt
    22261 tcggacggag accgaagtcg ggggcgtcgt acgttcggtg gtacgtgggc gtggcgctgg
    22321 cggagagcgg gggattgacc caggaccact gggtcggcac cggccgcccg gcctggccct
    22381 cggcgtccac gtggttgagg aactggcggg ccgcgctgtg gtggtcgacg atcagcacgc
    22441 cggcctggcg gtagctgtgc aggacagcat aggtgagctc gaccagggcg cggtccttcc
    22501 acagggtgcg gtcgtggcgg gtgtcgagtc ccatgcacgc ggcgacgtcc ggcaggacgt
    22561 cgtagcggta ggtgtcactg agattgcggg cgcctatctc ggagccgacg taccaaccac
    22621 tgaacggcgc cgcggtgtag ctgattccgc cgatctccag gcccatgttg gagaccgccg
    22681 gattcgcgtg ccatttcagc ccgagttcgg cgatccccgg cagctccgga tgactgatcg
    22741 gcacctcgag cagcgcgtcc gccgggacgt cgaaggcccg tgggtgatcg ccgggcatct
    22801 ggatgatgac aggcaggaca tcaaatgccc caccagtccc gttccatccc aatgcttggg
    22861 ccagctcggt gatttccaca tgcagcggat cgccgatcac cgtgccgtcg gcctgccggt
    22921 acccggcgta acggatcagc tgggggttga gaatgcggat ctcgccctgt gcggtgcgcg
    22981 gagcgaaaat cgttatcacc gagcgtagct ggcccttgtt ggtggactgc cgcagatgct
    23041 cccaacaggc ctgcgcgacc tcctcggcgg ttcggcagtg ccggaagtcg agcagtcgca
    23101 gtgagcgcca atgcatccga ccgatgcacc gtgcgtggtt gcgccaggcg accttggccc
    23161 cgatcagcag ctcgtcaggg gtgtgctggt agctgccgtc cgtctcgatg gcccgtctga
    23221 cctcggccag ccgggccttc ggcaggtggc tgagctctgg cagtcggtag aacgcctccg
    23281 cctcgcgcca caacacctcc ctggcgtcgg ggccttcggt cgactggact gcgggcggcg
    23341 ctaggggatt tggggtcatc atcatcgttc tgtgcgagcg gatccaggcg gctgcacccc
    23401 ccgggccttc cgaacgaatc ggtcgatcaa ggcgacggga ggaaatctgg acgaaaaagg
    23461 ggtgatttgg gccggatggg cactcgcgcg ccggcattcg ccacaagtcg ggtggagcgg
    23521 aagggatttc accatgtcta tgacggtaag tcaatgatct tcccccgact acgagatgac
    23581 cgtaaggaat cttcgatacc cacgatgatc ccgagttcgc gggcgggcgg ccgggcggac
    23641 gatccgaaag tggtccagtg gaccggtggg tgagtggccc attggcggac agaagactgg
    23701 cttacggtca agctgttaag tcgtcaaata cgggagtagt cgcatgaccg gcagcaggac
    23761 caacgtctgc atcatcggtg ctggcccgcg cgggctctcc gtcctggagc gcctgtgtgc
    23821 caacgagcgt gcgcagccct tgtgttcggc cctggtggtg catgtcgtgg acccgttcca
    23881 gccgggcgcc ggcgcggtct ggcgcaccga ccagtcccga cacctgctga tgaacaccgt
    23941 ggcctcgcag atcagcgtct acaccgacga cagctcgcag atcgacggcc cgatcgaacc
    24001 gggccccacc ctctacgagt gggcccgaca gctggccgga tccgacggtg cgcaggggtt
    24061 cgacggtgcg caggggttcg acggtgcgca tggcttcgat ggtgcgcagg agctcgacgg
    24121 tgcgcagggc ttcgacgacc agacgctggc ggaggcccgc gacctgcagc cgaacacgta
    24181 ccccacccgt gcgttctacg gcagttacct gcacgacagc ttccgccggg tggtggatcg
    24241 ggctccggag cacgtcacca tccaggtgca ccgctcgcgc gcggtcgccg tggccgactc
    24301 ccggggcagc ggggagaccc aggccgtctg cctggagaac ggcctctggc tggacgacct
    24361 gaacgccgtc gtcctggctc agggccatgt gccgacgcag ctgtcctccc gtgaggagcg
    24421 caccgcggag ttggcgcggg cgcaccgcct gacgtacatc cgtcccggca acccggcgga
    24481 ccaggacctc agcggcgtcc tgcccggcca gaacgtgctg ctgcgcggac tcggcctcaa
    24541 cttcttcgac cacatggcac tgttcaccat gggccgcggg ggcgtcttcg tccgggccgc
    24601 cgacgggcgc ctggcctacc agccctcggg cctggaaccg cgactgtacg cgagctcccg
    24661 gcgcggcgtg ccgtaccacg cccgcggtga gaacgagaag ggcgccttcg gtcgctactt
    24721 cccgaagctg ctcacggccc agtacgtcgc ggcccttcgc gagcgcgccg gcaagggcga
    24781 cgaggtgcgc ttcggcaccg acttgtggcc gctgatcgcc cgcgaggtgg agagcgtcta
    24841 ctacggggcg ctgctcgact cccgcggccg tggcgaggag cgggacgctt tcgtcgaggc
    24901 gtacctggcc gcggcggaca gcgccgaggt ggtgcacgcc ttcggtatcg cggcggacga
    24961 ccgctggagt tgggaactgc tctcccagcc gtaccgcgac cgggagttcg acagccggga
    25021 ggacttccag gagtggctgc tggggtacct ggcgcaggat gtcgcggccg cgatgcaagg
    25081 gaacctgacc ggtcctctga aggcagccct ggacgtgctg cgagacctgc gcaacgagat
    25141 ccgcctggcg gtggaccacg gtgggctgta cggcgactcg caccgcgacg agctggaggg
    25201 ctggtacacc ccgctcaacg ccttcctctc gatcggcccg ccggcctcgc ggatcgagca
    25261 gatgatcgcg ctgatcgagg ccggggtgct ggagctgacc ggcccgcaga cggagatccg
    25321 gatcgacacc gagtccgggg cgttcgtcgc gcacagctcc gtggttcccg ggcccgtggt
    25381 ccggtccacg gtgctgatcg aggccaggct gcaggaaccc gacctgcggc gcaccgccga
    25441 cccgctgctg cgcgcactgc tggagtccgc gcaggcggcc accttccgca tcgccacgtc
    25501 cgagggcagc tacgagaccg gcggcctcgc cgtgaccgag cgtccgtacc ggatcctcga
    25561 cgcgcagggc gcgccgcacc cgcgccgctt cgcctacggg gtgcccaccg agtccgtgca
    25621 ctgggtcacg gccgcgggca tccggcccgg ggtggactcg gtgaccctgg gtgactccga
    25681 ctcgatcgcc cgagcggtgc tcgccctgcc ggtggtggac cggggcgagg cagccgagag
    25741 cgcggcgact gcggccgagg gcgccggggt gatcgtatga gcgggcgagg cgacacgacg
    25801 caggacgcgg gactgctctc cccggtccga gccggtacgc cggtcgagga ggccgtctgc
    25861 gaccaggcat ggctgcaggc catgctcgac gccgaagccg ccctggcccg tgcccaggcc
    25921 aggctcggca ccgtgccggc ggccgccgcc cggaccatca gcgaggccgc ccgggccgag
    25981 aacttcgagc tgcgcgaact cgccctggcc gcccgggaaa ccgccaaccc cgtggtcggg
    26041 ctggtgcagg cgctcaccag ggtggtcagc gcgacggacc cggccgcggc cgagtacgtc
    26101 catcgcggat ccaccagcca ggacgtcttc gacaccgggg cgatgctggt cgcccggcgg
    26161 gccctgctga tcatccgcgc cgatctggcc cggacgacca ccgcgttggg agcactcgcc
    26221 aagcggcacc gcgacaccgt gatggcaggc cgcaccttgg cgctgcaggc cgtcccgacc
    26281 accttcggac tcaaggcggc cggctggcgg cagctgctcc tggacgcgga ccggcgtctg
    26341 ggtcaggtgt acgaccacgg cctgcccgtt gccctcggtg gtgcggccgg aaccctggcc
    26401 gggtacctgg agtacgccag gctcgacggc ggcgagcgag gcgagcccga cctcgaccgc
    26461 tacctcgacc tcgaccgcta cctcgacgcc ctggtggacg ccttcgccga cgagaccggg
    26521 ctcgcccgcc cggtcctgcc ctggcacgtg ctgcgaaccc cgatcgccga cctcgccgca
    26581 gcgctggcct tcaccgcagg cgccctgggc aagatcgcga tcgatgtgca gtccctcacc
    26641 cgcaccgagg tcggcgaggt caccgaaccc gcggtagccg gccggggcag ctcctcggcg
    26701 atgccgcaca aacgcaaccc ggtgctggcc acgttgatcc gcagtgccgc cctccaggtc
    26761 ccggcgatcg ccggcgcgct cagtcagtgc ctggtctcgg aggacgaacg ctcggccggc
    26821 gtctggcacg ccgagtggca gctgctgcgc gagtgcctgc gcctcaccgg cggcgccgcc
    26881 cacacggcgg tcgaactggc cgagggcctg gacgtgcgta ccgaccggat gttcgccaac
    26941 ctccagctga ccggcagtca gatcgtgtcc gaacgcatcg ccgccgtgct cgccccccac
    27001 ctcggcaagg tcgcggccaa gcaactcctc accgatgctg cgacccgctc ccaggaaacc
    27061 ggtgacccac ttcccaccgt cctcgccgcg acccccgccc tccaaggcat cctcgacccc
    27121 gccgccctcg ccaccctgtg cgacccctcg gcctacaccg gagccgcgtc ctccctggtg
    27181 gaccgcgccc tgcgc
//
