LOCUS       BGC0002538             17732 bp    DNA     linear   PLN 26-MAY-2020
DEFINITION  Chaetomium olivaceum strain SD-80A haetolivacine biosynthetic gene
            cluster, partial sequence.
ACCESSION   BGC0002538
VERSION     BGC0002538
KEYWORDS    .
SOURCE      Chaetomium olivaceum
  ORGANISM  Chaetomium olivaceum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae;
            Chaetomium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 17:56:36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17732
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..2992)
                     /gene="chaC"
     mRNA            complement(join(1..314,1754..2037,2062..2199,2423..2651,
                     2871..2892,2939..2992))
                     /gene="chaC"
                     /product="ChaC"
     CDS             complement(join(1..314,1754..2037,2062..2199,2423..2651,
                     2871..2892,2939..2992))
                     /codon_start=1
                     /gene="chaC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 49.8; E-value: 4.7e-15)"
                     /gene_kind="biosynthetic-additional"
                     /note="alcohol dehydrogenase-like protein"
                     /product="ChaC"
                     /protein_id="QJX57336.1"
                     /transl_table=11
                     /translation="MSHRKPENHLHLPQNAMINRSHQLESAGVGSDFSGTIIQLGEGVS
                     LETYGVKVGDRVAGAAHASNRLEPQGGAFAEYIAVCADQIWRVPDEMAFPQAAAIGLSG
                     FRVITTCSPANFTLVESYGAEKAFDYHSPTVMESIRAYTNNSLSAKSLRQCYASIGRAG
                     GRYVGFELVPDELTEIRKAVQASWVLGIRMFGTEIALDGGYGSPANPELRVWGCELFKR
                     LEKLIWEGKIRPHPVELDDKSVVTAEHSVRHNSFASPQIVLDLSRRVCVVVRRPNGVVY
                     GVAVLIAIDLCSKAPIPVLHGRTGGGHSAELVIWRKQPKEMLNGVERRFYRIGTRGARV
                     VGGWKL"
     source          1..17732
                     /db_xref="taxon:1087732"
                     /mol_type="genomic DNA"
                     /organism="Chaetomium olivaceum"
                     /strain="SD-80A"
     misc_feature    <1..>17732
                     /note="haetolivacine biosynthetic gene cluster"
     subregion       1..17732
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17732
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            3105..4725
                     /gene="chaB"
     mRNA            join(3105..3193,3468..4482,4723..4725)
                     /gene="chaB"
                     /product="hypothetical protein"
     CDS             join(3105..3193,3468..4482,4723..4725)
                     /codon_start=1
                     /gene="chaB"
                     /product="hypothetical protein"
                     /protein_id="QJX57337.1"
                     /transl_table=11
                     /translation="MQEVHSTYAGPTQVQVTVLAPSESQRSQTIHLTAFEQVEGPVAFS
                     LSPDEHPEVPKLSAINSTVWEQWEFDGVAVSGNASILMGFSRDPSYGFFGQGNLRVEFY
                     MTLEDGTRIQELEYTQQSTIIDCPGFVSGLWNSSDRFYAFRVSKDMQTAEVWWEARREK
                     GYLILESLAPPHLADGQLWPPSQQDPVVNHAAVTMAPGLYFNQPIAGGKMTAHVKIGNR
                     EMNITGYGAHCRLWAEDSWFKVCRGWQVVRGFLGPYTITYWQPLSRVNDWVSYFSANLF
                     KDGELVVGTQVGTGSRDTDHVLFGPEFSGNISGSLADKATGHMLEFVSSVSGRRWRFKH
                     SHQIKMFEMGLGGGRGLTGFVDDVAGGE"
     gene            5318..17732
                     /gene="chaA"
     mRNA            join(5318..5840,5943..6316,6383..11522,11724..11982,
                     12050..14649,14740..17732)
                     /gene="chaA"
                     /product="ChaA"
     CDS             join(5318..5840,5943..6316,6383..11522,11724..11982,
                     12050..14649,14740..17732)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (13-416). E-value:
                     1e-85. Score: 280.0. Matches aSDomain:
                     nrpspksdomains_chaA_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (530-854). E-value: 2.3e-89.
                     Score: 291.5. Matches aSDomain:
                     nrpspksdomains_chaA_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (929-1109). E-value: 9.6e-20.
                     Score: 63.4. Matches aSDomain:
                     nrpspksdomains_chaA_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1369-1577). E-value: 1.8e-76.
                     Score: 248.9. Matches aSDomain: nrpspksdomains_chaA_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2043-2217). E-value: 6.1e-50.
                     Score: 161.5. Matches aSDomain:
                     nrpspksdomains_chaA_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2361-2408). E-value: 2.1e-09.
                     Score: 29.5. Matches aSDomain:
                     nrpspksdomains_chaA_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (2521-2814). E-value:
                     1.2e-69. Score: 226.5. Matches aSDomain:
                     nrpspksdomains_chaA_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (2982-3389). E-value:
                     2.5e-84. Score: 275.1. Matches aSDomain:
                     nrpspksdomains_chaA_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (3510-3581). E-value: 2.7e-12.
                     Score: 38.6. Matches aSDomain: nrpspksdomains_chaA_PCP.1"
                     /NRPS_PKS="Domain: TD (3626-3865). E-value: 7.3e-43. Score:
                     138.4. Matches aSDomain: nrpspksdomains_chaA_TD.1"
                     /codon_start=1
                     /gene="chaA"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 109.8; E-value:
                     2.7e-33)"
                     /gene_kind="biosynthetic"
                     /note="Hybrid PKS-NRPS biosynthetic cluster"
                     /product="ChaA"
                     /protein_id="QJX57338.1"
                     /sec_met_domain="itr_KS (E-value: 4.8e-88, bitscore: 283.4,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.2e-90, bitscore: 291.5,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.8e-46, bitscore:
                     145.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 8.5e-53, bitscore:
                     167.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 9.7e-86, bitscore:
                     275.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 9.1e-13, bitscore:
                     36.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4e-31, bitscore:
                     95.7, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQSSEERFINEPIAIIGSACRFPGSLDNPSKLWDFLREPKDLLS
                     KIPTGRFNADAFFHPDSAHHGTSNVTKSYFLEEDPRLFDAAFFNIKPVEAHSIDPQHRI
                     LLEVVYESLEAGGQSIEALAKSQTGVYVGLMCGDFSEHIQRDIDAMPAYMATGTARSLI
                     SNRISYFFDWHAGSNIILGPELYIGESKLKMLSPSGRSRMWDEKADGYARGEGVAAIIL
                     KRLSDAIRDGDHIESVIRESAINSDGRTKGLTMPNELAQADLITRTYRKAGLDLAKESE
                     RCQFFEAHGTGTEAGDCREAEGISRAFLGYGSEGRNNRQRQTDNLYVGSIKTVIGHTEG
                     TAGLAGLLKASLAIQNATIPPNMLFERLSPKVAPFYNGLEIATKAKPWPKVTTVRRASV
                     NSFGFGGANAHVILENFEPSHETTDTCGPATFTPFVFSAGSETALEGMLEAYATHLRGQ
                     PDMSVGDLAYTLHARRSALALRAAFSAAPSALHLVSQIEEYLTQARHKENGTGSSGTSV
                     GTRPVSASPRVLGIFTGQGAQWAGMGRELIQTSEFVRSRIQSLENALRMLPGADRPSWS
                     LIDELLAEGASSRLGEARIAQPLCTAIQIVLVDLLHAADIRFAAVVGHSSGEIAAAYAA
                     SMINAEDAIKIAYYRGLCVEEHVKREGAMMAVGTTFDDATDLCSLDVFSGRLCVAACNS
                     PSSVTLSGDAEAVREAKEVLGDEKKFARPLKVDKAYHSHHMDVCSAPYLQALHACNIEP
                     QEPSSKCIWYSSVYPGSSMGMSVTDLETLKGEYWKENMLRPVLFTQALETAVRMSEDGP
                     FNLVIEVGPHAALKGPASETLAALYDENKLPRPPYVGTLSRGSNDIGALSATLGSVWSR
                     FSGPVVNFSQYDSLLAGQSGPFRRLVPNLPTYKWDHDRVYWHDSRISRALRNRKGAFNP
                     LLGRRIADGLGDEMRWRNILRPSELPWISGHQLQGQKVYPAAAYLSTAVESCAFVADGR
                     GVDAVEIQDFDLGKALVFDDNTEQAGVETLFVLSGISKRSQNHVTANFGFYAALGADAD
                     VLSRLATGRILVTLAVDLDASPRLLPQRAPEPVNMAEIQEEEFYSSLGKLGYEYANDFR
                     ALSGMKRKINYGSANVRVPGHKLAADALLVHPALLDSALQAIFLAYWHPDDGSLDQLHV
                     PTGISTLKINTSLCKQDLVQGVLLPLESVLTENPLVTNMIGGDVDVYSRDGRTPLIQVH
                     GVRVLPLAERTSHADRQLFREHVWGPSIPSGLLAANNRATPQDFELGSDLERMSIYYLK
                     RLTQEIPPSQRGGLEWHHKTLFEFADHVLHQTANGRQRFARTAWLNDTWDDIAHILDKH
                     PGSIEVELSHTVGENLAASARGETQILQHMFKDNLLNRYYVEAMGLRETTAFLSRIVAQ
                     IAHRYPHMDILEIGAGTGGATKAIFRDIGQTFSSYTFTDISTGFMEKAQEVFAKMAGKM
                     VFKALDIEKDIMEQGYAEHSYDLIIGSLVLHATGSLDKTMKETRRLLKPGGYLVLLEMT
                     SNDVLRVGFAMSGLPGWWLGAGDGRQYSPCVSSAKWHEILLGAGFSGIDTITPEVDTLP
                     RPFSVIVSQAVDQRVNVIREPLSHPDRLNADHANKELIIIGGRSLTTVVLISSLLDLTQ
                     EFGFNITRLSSLQELEGLAISPTALVLNLAELDEPVFENLTRETMKGIQSLVDYQRTIL
                     WITQGCRADQPYMNMSVGLGRTLALEAPDVRLQFLDLDVSHKVDARLVAETLLRLQLTR
                     EDSFTQGMLHSVEQEVVEEKGELMVPRLLPIKAANDRYNATKRSITQEKESDECSLLLV
                     PAKWGYTIRDATGDASLECAANGTLVHVTASTLMPITEQMYGVVGRDPDADTWVLGLSR
                     TNGNRVSVQGDHLVRFSSTQGEIMSDEQQQLVALLTIEAQCCQALSAVPSGGTLVVNEP
                     PTGLAERLLERSSESDTKVVFTVPSVAAHRGLPDGCVVVALAPTSSKRAARAALPTVVS
                     LFVDCSTGTEGVGLGSLVASLSGPTLVNWSGDKVLVRLESVDSLIRFDSNKTYVLFGLT
                     SDLGQSLVDWMASHGARNVVLTSRRPNIDHRWLDQCTASGVKVQVFANDITDPAAVEAL
                     VGQIRRSFPPIAGIMHGAMVLEDVPFSEMSLETMNKVVRPKVLGTLHLDRIFQENSLDF
                     FVFFSSLASASGNRGQSNYSAANMYMTAKTFERRRKGLAASVLHLGAVMGVGYVMREAS
                     ETVFPAIRRAGFQWMDERAFHQCVAEAILAGRPDSGRNPEIVTGLRVINIEEEEPTPWM
                     NNPRFQHCIAQGGTSEMKRTQGGATVAVKARLLEVTTPEGTLEVITDAFLQKLQIMLQV
                     QLQNDDDRANILIANAEDTGIDSLVAVEIRSWFQKEMEVDLPVLKILGGAAIADLIAFA
                     VEKLPAALTPNLGSATSDRRRDEPGHDSSPPVTVPLTRRSTMSVLATPDQTSSNGSEDC
                     TSISSGNTTPTLESETNVAFLEDEDSAKSGSTASGEMQLLGPLVSRPSHPQELDLERTA
                     PMSLGQSRFWFLRRYIEDQTTFNITFSVRLRGSLNLSKFESAVQTLGQRHQALRTAFVM
                     EGDQQLPVQAILKRSLLHVEKKQIKKAHEASTAFEAMKNHVFDIERGESMRLMVLSLSP
                     IDSFLVVGYHHINMDGASLEVFMADLMKLYTGKPLTPKPFQYPDFAVQQQLEVQQGRMD
                     GDIAYWETQLAGSPTAIPLLPYSSVKTRMAIHRYDHNRVDRKIDAALASRIRATCRGEK
                     TSQFHFYLAVFQVTLFRLLGTPDLCIGMADANRFEGDLASSVGMYLNLLPLRFRLSGSQ
                     TFQDTLKDTRRTAYGAMAHSHVPFDLILNSLNVPRSTLHSPLFQAFINYRAGVAEKRML
                     GAVEGEGEEYHFGRSAYDLSLDIMENPNSDPRLMFVVQKQLYSEQDADVLADAYMHLLE
                     YFAQKPTSALEAAPVFAPKTVEAAIQLGRGRPVVSGWPETIVHRVDDIVQRHPDTIAIR
                     ETQEGRVWNYKQFGDRTAAVAGALLSANVTQGARVAVFQEPGFDWICSAMAAMRVGAVF
                     VPFDVSTPVERLTAMVTTAKPTVVLFHRATASQEASLATIRDGCAQAIDVSQPFPSPVT
                     GHEDYVPIMAKSREAAILYFTSGSTGVPKGVMLPHDGIPNFMEHTCDVNGPEVVLHHSA
                     LGFDLATWQVLAALAHGGTLVVVPRALRGDAVAITALMAKEGVTCTGATPSEYTSWIQY
                     GFPKLTQCKGWRRAMTGGEQCSPKLVEDFRTLQLPDLRLWNCYGPSEVTWGSNQAEIAL
                     TKPLEGVVTVGNTMPNRSVYILDDNLEAVCVGMPGEVVIGGPGVGLGYLDNDALTAERF
                     IPDLSAPGTRMYRTGDRGRLAANGDLEILGRIDGDSQIKLRGIRIEMQDIEQTILRSAN
                     GALSNVCVTARGEPPSLVAHAVFGPDFSSQEQEQDAFLHRLATSLPLPQYMRPAAIVPI
                     PAMPLNLNGKLDRRAVERMPTRAGDAAIEQRPTGSTPLGEQELQLRHIWEHVIPGDVFA
                     LYAVNRDTDFFHVGGNSMLLVKLQDLIKREFGVTLTIMSLFENSTLGTMAAAVHDATIA
                     SADAAIDWEEETALTKDVIDGAWPSSEKAARRPKPAIDGKIIILTGATGFIGRELLAQL
                     ISSSAISKVYCIAVRDPTKLADLESDPKVSIHPGDLSSLDDVDEHLFSAAHAVIHCGAD
                     VSFLKTYATLRRANVASTKALARLALKHDVDFHYISTIATGRLLLADRSSAAEDGRPQT
                     ATAAQDIFREQSLADHPPPPGWLDNYVASKWASEVFLERAAARLGLKAWVHRPSSVTGA
                     GAGEMDVMSSVMRYAKSLRAVPVSARWRGALDFVGVQAVADGVVNTVIKGRDGGNQEPE
                     GSMKFLHHSGDVVIPIDVLKEYLEKEDAVEYKKVQLGEWIEMAVSEGLNVLVAAYLASV
                     DEMDLDIVFQSYVKGDIVASVEG"
     aSDomain        join(5357..5840,5943..6316,6383..6733)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.00E-85"
                     /label="chaA_PKS_KS.1"
                     /locus_tag="chaA"
                     /protein_end="416"
                     /protein_start="13"
                     /score="280.0"
                     /tool="antismash"
                     /translation="IAIIGSACRFPGSLDNPSKLWDFLREPKDLLSKIPTGRFNADAFF
                     HPDSAHHGTSNVTKSYFLEEDPRLFDAAFFNIKPVEAHSIDPQHRILLEVVYESLEAGG
                     QSIEALAKSQTGVYVGLMCGDFSEHIQRDIDAMPAYMATGTARSLISNRISYFFDWHAG
                     SNIILGPELYIGESKLKMLSPSGRSRMWDEKADGYARGEGVAAIILKRLSDAIRDGDHI
                     ESVIRESAINSDGRTKGLTMPNELAQADLITRTYRKAGLDLAKESERCQFFEAHGTGTE
                     AGDCREAEGISRAFLGYGSEGRNNRQRQTDNLYVGSIKTVIGHTEGTAGLAGLLKASLA
                     IQNATIPPNMLFERLSPKVAPFYNGLEIATKAKPWPKVTTVRRASVNSFGFGGANAHVI
                     LENF"
     aSModule        5357..12977
                     /complete
                     /domains="nrpspksdomains_chaA_PKS_KS.1"
                     /domains="nrpspksdomains_chaA_PKS_AT.1"
                     /domains="nrpspksdomains_chaA_PKS_DH.1"
                     /domains="nrpspksdomains_chaA_cMT.1"
                     /domains="nrpspksdomains_chaA_PKS_KR.1"
                     /domains="nrpspksdomains_chaA_PKS_PP.1"
                     /iterative
                     /locus_tags="chaA"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       6029..6067
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0001"
                     /evalue="1.40E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="chaA"
                     /protein_end="216"
                     /protein_start="203"
                     /score="11.9"
                     /tool="antismash"
                     /translation="WDEKADGYARGEG"
     CDS_motif       7076..7126
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0002"
                     /evalue="3.80E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="chaA"
                     /protein_end="547"
                     /protein_start="530"
                     /score="19.2"
                     /tool="antismash"
                     /translation="IFTGQGAQWAGMGRELI"
     aSDomain        7076..8047
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_PKS_AT.1"
                     /evalue="2.30E-89"
                     /label="chaA_PKS_AT.1"
                     /locus_tag="chaA"
                     /protein_end="854"
                     /protein_start="530"
                     /score="291.5"
                     /tool="antismash"
                     /translation="IFTGQGAQWAGMGRELIQTSEFVRSRIQSLENALRMLPGADRPSW
                     SLIDELLAEGASSRLGEARIAQPLCTAIQIVLVDLLHAADIRFAAVVGHSSGEIAAAYA
                     ASMINAEDAIKIAYYRGLCVEEHVKREGAMMAVGTTFDDATDLCSLDVFSGRLCVAACN
                     SPSSVTLSGDAEAVREAKEVLGDEKKFARPLKVDKAYHSHHMDVCSAPYLQALHACNIE
                     PQEPSSKCIWYSSVYPGSSMGMSVTDLETLKGEYWKENMLRPVLFTQALETAVRMSEDG
                     PFNLVIEVGPHAALKGPASETLAALYDENKLPRPPYVGTLSRG"
     CDS_motif       7340..7432
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0003"
                     /evalue="4.10E-09"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="chaA"
                     /protein_end="649"
                     /protein_start="618"
                     /score="28.9"
                     /tool="antismash"
                     /translation="AAVVGHSSGEIAAAYAASMINAEDAIKIAYY"
     aSDomain        8273..8812
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_PKS_DH.1"
                     /evalue="9.60E-20"
                     /label="chaA_PKS_DH.1"
                     /locus_tag="chaA"
                     /protein_end="1109"
                     /protein_start="929"
                     /score="63.4"
                     /tool="antismash"
                     /translation="PLLGRRIADGLGDEMRWRNILRPSELPWISGHQLQGQKVYPAAAY
                     LSTAVESCAFVADGRGVDAVEIQDFDLGKALVFDDNTEQAGVETLFVLSGISKRSQNHV
                     TANFGFYAALGADADVLSRLATGRILVTLAVDLDASPRLLPQRAPEPVNMAEIQEEEFY
                     SSLGKLGYEYANDFRAL"
     CDS_motif       8354..8425
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0004"
                     /evalue="3.00E-08"
                     /label="PKSI-DH_m2"
                     /locus_tag="chaA"
                     /protein_end="980"
                     /protein_start="956"
                     /score="26.2"
                     /tool="antismash"
                     /translation="WISGHQLQGQKVYPAAAYLSTAVE"
     aSDomain        9593..10216
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="1.80E-76"
                     /label="chaA_cMT.1"
                     /locus_tag="chaA"
                     /protein_end="1577"
                     /protein_start="1369"
                     /score="248.9"
                     /tool="antismash"
                     /translation="LQHMFKDNLLNRYYVEAMGLRETTAFLSRIVAQIAHRYPHMDILE
                     IGAGTGGATKAIFRDIGQTFSSYTFTDISTGFMEKAQEVFAKMAGKMVFKALDIEKDIM
                     EQGYAEHSYDLIIGSLVLHATGSLDKTMKETRRLLKPGGYLVLLEMTSNDVLRVGFAMS
                     GLPGWWLGAGDGRQYSPCVSSAKWHEILLGAGFSGIDTITPEVDT"
     CDS_motif       11816..11914
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0005"
                     /evalue="7.10E-13"
                     /label="PKSI-KR_m1"
                     /locus_tag="chaA"
                     /protein_end="2076"
                     /protein_start="2043"
                     /score="41.1"
                     /tool="antismash"
                     /translation="TYVLFGLTSDLGQSLVDWMASHGARNVVLTSRR"
     aSDomain        join(11816..11982,12050..12404)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_PKS_KR.1"
                     /evalue="6.10E-50"
                     /label="chaA_PKS_KR.1"
                     /locus_tag="chaA"
                     /protein_end="2217"
                     /protein_start="2043"
                     /score="161.5"
                     /tool="antismash"
                     /translation="TYVLFGLTSDLGQSLVDWMASHGARNVVLTSRRPNIDHRWLDQCT
                     ASGVKVQVFANDITDPAAVEALVGQIRRSFPPIAGIMHGAMVLEDVPFSEMSLETMNKV
                     VRPKVLGTLHLDRIFQENSLDFFVFFSSLASASGNRGQSNYSAANMYMTAKTFERRRKG
                     LAASVLHLGAV"
     CDS_motif       12252..12344
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0006"
                     /evalue="2.40E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="chaA"
                     /protein_end="2197"
                     /protein_start="2166"
                     /score="52.2"
                     /tool="antismash"
                     /translation="LDFFVFFSSLASASGNRGQSNYSAANMYMTA"
     aSDomain        12837..12977
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_PKS_PP.1"
                     /evalue="2.10E-09"
                     /label="chaA_PKS_PP.1"
                     /locus_tag="chaA"
                     /protein_end="2408"
                     /protein_start="2361"
                     /score="29.5"
                     /tool="antismash"
                     /translation="AEDTGIDSLVAVEIRSWFQKEMEVDLPVLKILGGAAIADLIAFAV
                     EK"
     aSDomain        13317..14195
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.20E-69"
                     /label="chaA_Condensation_LCL.1"
                     /locus_tag="chaA"
                     /protein_end="2814"
                     /protein_start="2521"
                     /score="226.5"
                     /tool="antismash"
                     /translation="TAPMSLGQSRFWFLRRYIEDQTTFNITFSVRLRGSLNLSKFESAV
                     QTLGQRHQALRTAFVMEGDQQLPVQAILKRSLLHVEKKQIKKAHEASTAFEAMKNHVFD
                     IERGESMRLMVLSLSPIDSFLVVGYHHINMDGASLEVFMADLMKLYTGKPLTPKPFQYP
                     DFAVQQQLEVQQGRMDGDIAYWETQLAGSPTAIPLLPYSSVKTRMAIHRYDHNRVDRKI
                     DAALASRIRATCRGEKTSQFHFYLAVFQVTLFRLLGTPDLCIGMADANRFEGDLASSVG
                     MYLNLLPLRFRL"
     aSModule        13317..17438
                     /complete
                     /domains="nrpspksdomains_chaA_Condensation_LCL.1"
                     /domains="nrpspksdomains_chaA_AMP-binding.1"
                     /domains="nrpspksdomains_chaA_PCP.1"
                     /domains="nrpspksdomains_chaA_TD.1"
                     /final_module
                     /locus_tags="chaA"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       13380..13496
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0007"
                     /evalue="2.80E-12"
                     /label="C2_LCL_024-062"
                     /locus_tag="chaA"
                     /protein_end="2581"
                     /protein_start="2542"
                     /score="39.0"
                     /tool="antismash"
                     /translation="TTFNITFSVRLRGSLNLSKFESAVQTLGQRHQALRTAFV"
     CDS_motif       13701..13766
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0008"
                     /evalue="5.20E-07"
                     /label="C3_DCL_135-156"
                     /locus_tag="chaA"
                     /protein_end="2671"
                     /protein_start="2649"
                     /score="22.3"
                     /tool="antismash"
                     /translation="YHHINMDGASLEVFMADLMKLY"
     CDS_motif       14097..14186
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0009"
                     /evalue="6.10E-05"
                     /label="C5_LCL_267-296"
                     /locus_tag="chaA"
                     /protein_end="2811"
                     /protein_start="2781"
                     /score="15.5"
                     /tool="antismash"
                     /translation="DLCIGMADANRFEGDLASSVGMYLNLLPLR"
     CDS_motif       14235..14351
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0010"
                     /evalue="2.00E-12"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="chaA"
                     /protein_end="2866"
                     /protein_start="2827"
                     /score="39.4"
                     /tool="antismash"
                     /translation="RRTAYGAMAHSHVPFDLILNSLNVPRSTLHSPLFQAFIN"
     aSDomain        14790..16010
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_AMP-binding.1"
                     /evalue="2.50E-84"
                     /label="chaA_AMP-binding.1"
                     /locus_tag="chaA"
                     /protein_end="3389"
                     /protein_start="2982"
                     /score="275.1"
                     /tool="antismash"
                     /translation="DIVQRHPDTIAIRETQEGRVWNYKQFGDRTAAVAGALLSANVTQG
                     ARVAVFQEPGFDWICSAMAAMRVGAVFVPFDVSTPVERLTAMVTTAKPTVVLFHRATAS
                     QEASLATIRDGCAQAIDVSQPFPSPVTGHEDYVPIMAKSREAAILYFTSGSTGVPKGVM
                     LPHDGIPNFMEHTCDVNGPEVVLHHSALGFDLATWQVLAALAHGGTLVVVPRALRGDAV
                     AITALMAKEGVTCTGATPSEYTSWIQYGFPKLTQCKGWRRAMTGGEQCSPKLVEDFRTL
                     QLPDLRLWNCYGPSEVTWGSNQAEIALTKPLEGVVTVGNTMPNRSVYILDDNLEAVCVG
                     MPGEVVIGGPGVGLGYLDNDALTAERFIPDLSAPGTRMYRTGDRGRLAANGDLEILGRI
                     DGDSQIKL"
     CDS_motif       15228..15287
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0011"
                     /evalue="1.80E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="chaA"
                     /protein_end="3148"
                     /protein_start="3128"
                     /score="23.5"
                     /tool="antismash"
                     /translation="AILYFTSGSTGVPKGVMLPH"
     CDS_motif       15804..15890
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0012"
                     /evalue="1.30E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="chaA"
                     /protein_end="3349"
                     /protein_start="3320"
                     /score="39.9"
                     /tool="antismash"
                     /translation="VGMPGEVVIGGPGVGLGYLDNDALTAERF"
     CDS_motif       15993..16043
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0013"
                     /evalue="1.30E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="chaA"
                     /protein_end="3400"
                     /protein_start="3383"
                     /score="14.8"
                     /tool="antismash"
                     /translation="DSQIKLRGIRIEMQDIE"
     aSDomain        16374..16586
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_PCP.1"
                     /evalue="2.70E-12"
                     /label="chaA_PCP.1"
                     /locus_tag="chaA"
                     /protein_end="3581"
                     /protein_start="3510"
                     /score="38.6"
                     /tool="antismash"
                     /translation="QLRHIWEHVIPGDVFALYAVNRDTDFFHVGGNSMLLVKLQDLIKR
                     EFGVTLTIMSLFENSTLGTMAAAVHD"
     aSDomain        16722..17438
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chaA_TD.1"
                     /evalue="7.30E-43"
                     /label="chaA_TD.1"
                     /locus_tag="chaA"
                     /protein_end="3865"
                     /protein_start="3626"
                     /score="138.4"
                     /tool="antismash"
                     /translation="IILTGATGFIGRELLAQLISSSAISKVYCIAVRDPTKLADLESDP
                     KVSIHPGDLSSLDDVDEHLFSAAHAVIHCGADVSFLKTYATLRRANVASTKALARLALK
                     HDVDFHYISTIATGRLLLADRSSAAEDGRPQTATAAQDIFREQSLADHPPPPGWLDNYV
                     ASKWASEVFLERAAARLGLKAWVHRPSSVTGAGAGEMDVMSSVMRYAKSLRAVPVSARW
                     RGALDFVGVQAVADGVV"
     CDS_motif       16725..16787
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chaA_0014"
                     /evalue="1.50E-01"
                     /label="PKSI-KR_m1"
                     /locus_tag="chaA"
                     /protein_end="3648"
                     /protein_start="3627"
                     /score="4.8"
                     /tool="antismash"
                     /translation="ILTGATGFIGRELLAQLISSS"
ORIGIN
        1 ctacagcttc caacccccga caacacgagc tccccgtgtt ccaatacgat agaagcgccg
       61 ctcgacacca ttgagcattt ctttgggttg cttccgccag ataacgagct cggcggagtg
      121 gccgcctccg gtgcgaccat ggaggacagg gatgggtgct ttggagcaga ggtcaatggc
      181 gatcaacact gcaacgccgt agacaacacc attgggtcgc ctcacgacga cacagacacg
      241 cctggacaaa tccaacacaa tctgggggct ggcgaagctg ttgtgtcgga cgctgtgctc
      301 ggcggtcacg acgccttaat atcgctgtcc cgtcttaatg tgagcgtcag tcagcagctt
      361 gtcaaattcg actcataccc ctggcatgat gccccgttga tgcagtccct ctgtttttca
      421 agaatcaacg ccaccgctga taatcccgtg gccaaggcgc tgcaaaccac gacacgtttt
      481 gtagcgatcc tcaagagcct atcacactct aagtgtaacc aggcttttgg gaccaggtcg
      541 ttcttggact tgtgcgtctc cagcaaccac ggcagcagca cccgcgacga tgttacctcc
      601 ctcgggggca cccctgcgcc ttctcctttc tgcgcggcga cgtatttact cctactctcc
      661 agttacattc agatcgtgca cctgttcaac gccatgttcc gtcgtatggc cgaggtttta
      721 ggcgatatga ccgaggaagc cataagcaag ttccaaccgc aacctgactt ccgcgtcgct
      781 ggactcccta ccatgcccag tcgcctctac ctcaaaatct taatgcaaat catcgacgac
      841 cagatagaaa gcattgagtg cttgatgggt atctcggccg aatgctgcct gtcgggccgg
      901 gctccggcac ggaagggaat tttcagcgac caagatgtat cggcgctatt ggagactatc
      961 atgggccagg ggggtggtag tagcagttca agcagcgcct tccaagagaa gttgatcgtg
     1021 atttcgttac gtgagagcat ggcgacggtg aaggagctct tgaggggtta aggctggaaa
     1081 actcttttcc taacaacatg gttaacgtaa atcataaatg tgtacaacaa gccagtgtgc
     1141 aatttctcaa gtaaggcgct agctctctcc tcaacatcga tttcttttct acgatttaac
     1201 atgcctactg ctttagacta aagcaaagta atcttagccc gctaaggctt tcacaatgac
     1261 aaagcttcaa aggttcctat aacagtacct ccttcataaa ccgctcttct aacggcccgc
     1321 tagacatctc ctccctgaaa gtctcgctcg cgtttttccc tctacgcaca gccgcctatc
     1381 caaccattca accccgacag taattgcccc cagattacgc ctattactag tatctttctt
     1441 atgcctacca ttggctccct gatcgacttt ggttgaaccc acggagtaga taaagggcga
     1501 atagaccgtt agatgtgaat gaccactatc caacgccaaa aagatagaat cgttatccgc
     1561 tctatctact ttagtaaacc cgtcatcgca taccacgaac catggtcaca gccggggata
     1621 actaaaacac ttgataatgc tcccagcgta accgaaagat ttccgtttta atcaagcata
     1681 aaaactaatt tcttccccga aacctctcct ctcttcaact tctccacccc tcggacaatc
     1741 ccatcaaacc cactcttatc atccaactcc actgggtgtg gccggatttt gccctcccag
     1801 atcaactttt ctagcctctt gaacagctca caaccccaca ctcttaactc ggggttggcg
     1861 ggactcccat aacctccatc cagcgcaatc tcggtcccaa acatccggat gcccaacacc
     1921 cagctagcct ggacagcctt gcgaatttcc gtcaactcat ccgggacgag ctcgaagcca
     1981 acatagcgtc ctcctgcacg gccgatacta gcgtagcact gtcgcaacga tttggcacta
     2041 gctataatgt ccatcacgta cctcaggctg ttgttagtgt aggcgcgaat cgactccatg
     2101 actgttggtg agtgatagtc gaacgccttc tcagcaccgt atgactccac caaggtgaaa
     2161 ttggcgggtg agcaggtagt gatgacccgg aagccagatc tgtcgattca cattagcaca
     2221 ccctactcgc tcgcggacat ctcagacagc gtacagcttc agcaactgga tggcggccgt
     2281 tccacttgcc gtactcccgc cgtacacaag cacccatggc tttgcctggt cacttgtctc
     2341 gccgattgga ttctcagggg agccgggcaa cgctaggtgc cgggcgccga aacatgccag
     2401 ccctacagtt ccgacaacgc acagccctat cgcagctgct tggggaaacg ccatctcatc
     2461 tgggacccgc cagatctgat cggcacaaac agcaatgtac tcggcaaagg caccgccttg
     2521 cggctccaac cgattggacg cgtgggccgc gccggccacg cgatcgccca ctttaacacc
     2581 gtatgtttcg agggataccc cttctccgag ttggatgatt gtgccggaaa agtcagatcc
     2641 gaccccggcg cctggacagg gaaagttcgt tggcattttc cagtcacacg gattcagggc
     2701 gacagcggcg acatggacga gcacctggcc cggtaggggc attggtatgg gtcgcgttcg
     2761 agtgaatgcg aggattcccg gggttgagga ctgaatcaaa gctcgttgaa aggaaggcat
     2821 gtcgaatcta ccgtttgtga atggtttcga aaaggatgcg atcgtctcac tctccagctg
     2881 gtgtgatctg ttctaattta caagaggcat tgagtactgt gtaaaaatcg taacttacaa
     2941 tcatcgcgtt ctggggtaaa tgcaggtggt tttcgggctt gcggtgagac attcgcattt
     3001 tgacggggaa gaacggaggc cgacagaatt ggcgggctcg atggcatcgg aaaccgatgt
     3061 tgtcgccgac gcaagatcgt ctccgatttc agaagcctcc gacaatgcag gaagtccaca
     3121 gtacctacgc tggtcccacc caagtgcaag tgacggtcct cgcgccatcc gagagtcaaa
     3181 ggtcccaaac aatgtgtgtt caatacacaa gtcaacaact tctagctccc caaacaaaat
     3241 acgtcttggc tccatgccat cccacatagg caatctcgtg tttttacttc cactttgaca
     3301 ccccagctca ggatgggact tgcggctcga aagctctttt tggcgctgct tcccctggtg
     3361 gttggcgacc ttcatctggc acaacagccg ctagaaggtt tgctctccgg tcactggcag
     3421 cacgaattcg atacattgga tcagcatgac acgtcatgta tcatcagcca cctcacggcg
     3481 ttcgagcaag tcgagggacc cgtggcattt tccctctcgc cggacgagca ccccgaggtc
     3541 cccaaattgt cagcaattaa ttccaccgtc tgggagcagt gggaatttga tggggtagct
     3601 gtgtcgggga atgcaagcat cctcatgggg ttctcacggg atccttcata cggctttttc
     3661 gggcagggca acttacgcgt cgagttctac atgacgcttg aggacggcac ccgcatccag
     3721 gaactagagt acacccagca atcaaccatc atagactgtc ccggcttcgt cagcggactt
     3781 tggaacagct ctgaccgctt ctacgctttc cgagtgtcaa aggacatgca gacggccgaa
     3841 gtgtggtggg aggcccggcg tgaaaagggc tacctgatcc tagagtcgct tgcgccacca
     3901 cacctcgctg atggacagct gtggcccccg agtcagcaag acccagtcgt gaatcatgcg
     3961 gcagtcacga tggcgccggg actgtacttt aaccaaccca tcgccggcgg caagatgact
     4021 gcccatgtca aaatcggcaa cagagaaatg aatatcaccg gctacggcgc acactgccgg
     4081 ctgtgggcag aggacagctg gttcaaggtc tgccgcggct ggcaagttgt gcgagggttt
     4141 ctcggccctt acacgattac ctactggcaa cctctgtcga gagtgaacga ctgggtctca
     4201 tacttttcag cgaacctctt caaggacggc gagttggtcg ttggcacgca ggtcggaact
     4261 ggttctagag ataccgacca cgtccttttc ggtccagagt ttagcgggaa cattagcggc
     4321 agcctggccg acaaagccac gggacacatg ctcgagtttg tgtccagtgt cagcgggagg
     4381 agatggcggt tcaaacatag ccaccaaatc aaaatgttcg agatgggact tggcggcggc
     4441 aggggattga caggttttgt cgacgacgta gcgggcggtg aggtagggac agatgagcac
     4501 tttgagggga agggaatatc cgagcaggtt tccttgccag ataaagtgaa acagtggcag
     4561 atctgggttg tatatgggat tgggttccta ggaagatgga aaaacagtct ggcgagcttt
     4621 gtaccatcac tttggtaggg acagtcctcg tttgcagcaa ggaattaatc ccactcatac
     4681 catgagagca ttactctgcc gctggcgagc ataattacca agtagatggc tgtgaattta
     4741 caacactagt ttacactggc gacaacttgc catcgtgcta gttccaggtc cgagtcggat
     4801 attttgacag acgaaaaagc aattcggtcc tggaccaacc gcaaccatgt gctcagcaca
     4861 aacaggaact ttccgaaacc taggagccta tgccgtttcc agaggtcgct tcggcatgac
     4921 caccgcgatg cgctaatacc tgcgccgagg ccggggtttc ctaaccgaaa ggcggagagc
     4981 cgaatgtctc gggtttgaaa cctaaacaaa ctcgtatagt ttcccgctat tcggacagtt
     5041 gaatcatcga gcccgccctg gcagtaacta tgggttgact tattcctgtt acgtatcaac
     5101 tactgtccga atcaaacact cctcggtatt tgttaaaact attcaacatg cagccctgag
     5161 tgatctcgaa cgtacggcaa gccctggggt ttctttggct tcgcgtgtta cgttgtcacc
     5221 agagctcaac tctcgcgaca gaatccgcca attgcccccc ttctgttatt cgagcttcta
     5281 tccataccta cttggcgcca aaagaatctc agtcacaatg cggcaatcct ctgaagagcg
     5341 gttcatcaat gagcccatcg caatcatcgg aagtgcttgt cggttcccag gctcgctcga
     5401 caacccttcc aagctctggg atttcctccg cgaacccaaa gacttgctct ccaagatacc
     5461 gaccggccgc ttcaacgcag acgccttctt ccacccagat agtgcccacc atggaaccag
     5521 caacgtcacc aagagttact ttctggaaga ggatccccga ctgttcgatg cggccttttt
     5581 caacatcaaa cccgtcgagg cccactcgat cgatccccaa catcgaattc tccttgaggt
     5641 ggtgtacgag tcgctggagg ctggcggaca gtcgatcgag gcccttgcaa agtcccaaac
     5701 tggagtctac gttggtctca tgtgcggaga cttcagcgaa cacattcagc gggacattga
     5761 cgccatgcca gcctacatgg ctactgggac ggctagaagc ctcatctcca accgcatttc
     5821 ttatttcttt gactggcatg gtccgtcgat gacgattgac acggcttgct cctctagcct
     5881 ttttgccgtc catcaagcgg tacagctgtt gcgtagcggt gactcgaacc tcgtcgtcgc
     5941 agcgggctcc aacatcattc tcggtcccga actctatatt ggcgagtcca aactcaaaat
     6001 gctatcaccc agcggtcgat ctcgaatgtg ggatgagaaa gcggacggct atgccagggg
     6061 cgaaggagtc gcggccatca ttctgaagcg tctcagcgat gcaatccggg acggtgatca
     6121 cattgagtcc gttattcggg agtctgccat caactcggac ggtcgcacca aggggctcac
     6181 aatgcccaat gagcttgcgc aagccgacct aatcacccgt acctatagaa aggccggact
     6241 tgacttggca aaagaatcag agcgctgcca gttcttcgaa gctcatggta caggcactga
     6301 ggctggcgac tgtcgtgtaa gttcggcagg cagttggtgt gccgagacga gtctgcacta
     6361 accttgtctg attcttcgat aggaagccga agggatcagt cgagctttcc tcggatacgg
     6421 aagcgagggc cgtaacaaca gacagaggca gacagacaat ctttacgtcg gatcgatcaa
     6481 gacggtcatc ggccataccg aagggacagc cggcctcgct ggactgctca aggcctcgct
     6541 ggccatacag aacgccacaa ttccgcccaa catgttgttt gagcggctaa gccccaaggt
     6601 ggccccgttt tacaacggcc tggaaatagc caccaaagcg aagccatggc caaaggttac
     6661 cacagtccgg cgggcaagtg tcaacagctt cggctttggc ggcgcaaatg cccacgtcat
     6721 ccttgagaac tttgagccct ctcacgagac aacggacacc tgtggtcctg ccacattcac
     6781 tccattcgtc ttttctgcgg gttcagagac agccctcgag ggcatgctag aggcttatgc
     6841 aacgcacctg cgcggccaac ccgacatgtc cgttggtgat ctcgcttaca cgctgcatgc
     6901 gaggcgatca gcactcgcgc tgagagcagc attctctgcc gccccgtccg ccctgcacct
     6961 cgtctcccag attgaagaat accttaccca ggcccgccac aaagagaatg ggactggatc
     7021 atccggcacc agcgttggca cccgaccggt gagcgcttcg cctcgggtcc tcggcatttt
     7081 caccggccaa ggtgcgcaat gggctggaat gggtcgcgag ctaattcaga cctcggagtt
     7141 tgtgcgcagc cgtatccagt ccttggagaa cgccttgcgt atgctccccg gggctgatcg
     7201 gccttcgtgg tcacttattg acgaactgct agctgaggga gcatcttcgc gccttggtga
     7261 agcgcgcatt gcccaacctc tatgcactgc tattcagatt gttttggtcg acctcctcca
     7321 cgcagcagac attcggttcg cggctgttgt gggccactcc tcgggtgaga ttgcggcagc
     7381 ctacgctgcg agcatgatca atgccgagga cgcaatcaag atcgcctact accgcgggct
     7441 gtgcgttgag gagcacgtca agagggaggg ggccatgatg gctgtcggaa cgacgtttga
     7501 tgatgccact gacctgtgca gcttggacgt gttttccggc cgtctctgcg tggccgcttg
     7561 taactctccg tccagtgtca cactatccgg cgatgctgag gcagtccgag aggcaaagga
     7621 ggttttgggg gatgagaaga agtttgcccg acctctcaag gtggacaagg cataccactc
     7681 gcaccatatg gacgtctgct cagctccata cttgcaggcg ctacacgcct gcaatatcga
     7741 gccgcaggag ccgagcagca agtgtatctg gtattcaagc gtctacccag gttccagcat
     7801 gggaatgtcg gttacagacc ttgaaacttt gaagggggag tactggaagg aaaacatgct
     7861 acgacctgtt ctctttaccc aggcactcga gacggcagtc cgtatgagcg aggatggacc
     7921 gttcaacctt gtcatcgagg tgggccctca tgccgcactg aagggccctg catcagagac
     7981 cctcgcggct ttgtatgatg agaacaagct gcctcggccg ccatacgtcg ggacgctgtc
     8041 ccgcggttcc aacgacatcg gcgccttgtc tgccacgctg ggctctgtgt ggagtcgatt
     8101 cagcggaccc gtcgtcaact tctcccagta cgactcactt ctcgcagggc aatccgggcc
     8161 gttcagacgc ctcgtcccaa atctcccgac atacaagtgg gatcatgaca gagtgtactg
     8221 gcatgactcg agaatctctc gggcactacg caaccgcaag ggtgcattca acccactgct
     8281 ggggcgaaga attgcagatg ggttaggtga cgaaatgcga tggcgcaaca tcctccgccc
     8341 aagcgagctt ccctggatca gtggccacca gcttcaaggc caaaaggtat acccggctgc
     8401 cgcctatctg tctactgccg tcgagtcttg cgcattcgta gccgacggcc ggggcgttga
     8461 cgccgtggag atccaagact ttgatttggg aaaggccttg gtttttgacg ataacaccga
     8521 gcaagccggt gtcgagacgc tctttgtcct ctctggcata tctaagcgga gccagaacca
     8581 cgtcacagcc aatttcggct tctacgcagc tctaggagct gacgccgatg tactctctcg
     8641 tctcgcgacc ggccgcattc tagtcacact agccgtagac ttggatgcgt cgcctcgtct
     8701 tttaccgcag cgagcccccg agccagtcaa tatggccgag attcaggagg aggaatttta
     8761 ctcgtcactc gggaaactgg ggtacgagta cgccaacgac ttccgcgctc tgtcggggat
     8821 gaagagaaag atcaactacg gctcggccaa cgtgcgagtt ccaggtcaca agctcgccgc
     8881 tgacgctctt ctagtccacc cggccttgct ggactcggct ttgcaggcaa tcttcttggc
     8941 ttactggcac ccggacgatg ggagtctcga ccagctccac gtgccgacgg gtatttccac
     9001 tctgaaaatc aacacgtcgc tgtgcaaaca agacttggtc cagggagtgc tgctgcccct
     9061 tgagtccgtc ttgacggaga accccctggt caccaacatg atcggaggag acgttgacgt
     9121 ctatagccgt gacgggcgca cacccttgat tcaggtccac ggtgtccggg tcttgcccct
     9181 tgccgagcgc accagccatg ctgatagaca gctttttagg gagcatgtct ggggccccag
     9241 cattccaagc ggtctcctgg cagccaacaa tcgtgccacg ccgcaggact tcgagcttgg
     9301 tagtgacttg gagagaatgt ccatttacta cttgaaaagg ttgactcagg agatcccgcc
     9361 cagccaacgc gggggattgg agtggcacca caagaccctc tttgagtttg ctgatcacgt
     9421 tcttcaccag accgccaatg ggcggcagcg ttttgccagg acagcttggc tcaacgacac
     9481 ctgggacgat attgcacaca tccttgacaa gcacccgggg agcatcgagg tcgagctgag
     9541 ccacacggtg ggcgagaatc tcgctgcttc ggcacggggg gagactcaaa ttcttcaaca
     9601 catgttcaaa gataacctcc tgaaccggta ttacgttgag gcaatgggtt tacgtgagac
     9661 caccgccttt ctgtcccgga ttgtggcaca aatagcacac cggtatcccc acatggacat
     9721 cctcgagatt ggcgccggca cgggcggtgc aacaaaagcc attttccggg acattggaca
     9781 gacattttcc tcatatacat ttaccgacat atcgactgga tttatggaga aggctcagga
     9841 ggtctttgcc aagatggccg gcaagatggt gttcaaagcg ctcgatatag agaaggatat
     9901 catggaacag gggtatgcag agcactcgta cgacctgatc atcggctctc tagttttgca
     9961 cgcaaccggg agcctcgaca agaccatgaa agaaacgcgg cgactactga agcctggtgg
    10021 atatctcgtt cttcttgaaa tgacgagcaa tgatgttctc cgggtcgggt ttgccatgag
    10081 tggcctccct ggatggtggc tcggcgcggg cgatggtcgg caatactcgc cctgtgtttc
    10141 ttcggcaaaa tggcacgaga ttctccttgg ggccggcttt tcgggcattg acacgatcac
    10201 cccagaggtc gacactcttc cgcgtccctt ctccgtcatt gtttctcagg ctgtcgacca
    10261 gcgcgtcaac gtcatccggg agccgttgtc gcaccccgac agactgaatg ctgaccatgc
    10321 gaataaggag ttgatcataa ttggtggacg gagcttgaca accgtggttt tgatatccag
    10381 cctcctcgac ctaacgcagg agtttggttt caacattacc cggttatcct cgctccagga
    10441 actggaaggg ctcgccatat ccccgacggc tctcgtgtta aatctggctg aacttgacga
    10501 gcccgtcttt gagaacctca cccgcgagac gatgaaaggg atccagagct tggtggacta
    10561 ccagaggaca attctctgga tcacgcaggg ttgccgcgcc gatcaaccgt acatgaacat
    10621 gagcgtgggg cttgggcgga ccttggcctt ggaggctcca gatgttcgac tgcagtttct
    10681 cgacctcgac gtttctcaca aggtcgatgc gaggttggtg gccgaaaccc tgcttcgcct
    10741 acaactcact cgcgaagaca gttttactca ggggatgctc cattcggtag aacaagaggt
    10801 cgtcgaggag aagggagaac tcatggtccc acgactactt cccatcaagg cagccaacga
    10861 caggtacaac gccaccaaaa ggtccatcac ccaggagaaa gaaagcgacg aatgctcgct
    10921 cctactggtc cctgcgaagt ggggttacac gatccgtgac gctaccggcg acgctagtct
    10981 cgaatgtgct gccaacggga cactggtcca cgtcacggca tctactttga tgccaatcac
    11041 cgagcagatg tatggtgtcg ttggacgaga ccctgatgct gacacttggg tcttgggact
    11101 ttcacgtacc aatggcaacc gcgtgtctgt acaaggagac cacttagtcc gcttcagcag
    11161 cacacaaggg gaaataatgt cggatgaaca gcaacaactc gtcgccctgc taaccatcga
    11221 agcgcaatgt tgccaagccc tttctgcggt gccgtccggt ggtacgctgg tcgtgaatga
    11281 gcctcctacc ggcttggctg agcggcttct agagcgatcc agtgagagcg atacgaaggt
    11341 agtcttcact gtgccaagtg tcgctgccca ccgcggcctc cccgacggct gcgttgtagt
    11401 ggctctggcg ccgacgagtt caaagcgtgc cgcacgcgcc gctctcccta ccgtcgtctc
    11461 actctttgtg gactgctcta ctggcaccga aggcgtcggt cttggctccc tcgtcgcgtc
    11521 ttgtatgcct gcatcctgtc agcgcctaac actgacagag ctcagtcttc tacaccaacc
    11581 actgtcagcc tcaacaggca caatttccca aatgctccag caggtagttg gccgtcacgt
    11641 ccgggaaacc aagccggaaa cgagcttcct caccttgagc ccgaatacgc tgattaacac
    11701 accctatgtc gacttgtctg cagtatccgg cccaacattg gtgaattggt ccggggataa
    11761 ggtcctcgtg cgactggagt cagttgacag cttgattcga tttgacagca acaagactta
    11821 tgttttgttc ggcttgacga gcgatctggg acagtctttg gttgactgga tggcatcgca
    11881 cggggccaga aatgtcgtat tgacgagtcg acgccctaac attgaccaca gatggttgga
    11941 tcagtgcacc gcgagcggag tgaaggtaca ggtctttgca aagtgagtca atcaccccca
    12001 tccccaaagt cctcatgagt aaggaaaagg aaaatgctga cagagacagt gacattaccg
    12061 acccggccgc cgtggaagct ctcgttggcc agatccgtcg ctccttccca ccaattgcgg
    12121 ggatcatgca cggcgccatg gtcctagagg atgtcccttt ttcagagatg tctctcgaga
    12181 ccatgaacaa ggtggtgcgg cccaaggtgc tcggcaccct ccatctcgac cgcatattcc
    12241 aggaaaacag ccttgacttc ttcgtcttct tctcctcgtt ggcctcggcc tctgggaacc
    12301 gagggcagtc taattatagc gccgccaata tgtacatgac ggccaagact tttgagcggc
    12361 ggcggaaggg tcttgcagct tcagtcctgc atcttggagc tgtcatgggc gtgggctacg
    12421 tcatgcgaga ggcgagcgaa accgtgtttc cggccattcg ccgcgccggt tttcagtgga
    12481 tggatgaacg agccttccat cagtgcgtcg ccgaagccat cctagcagga cggccggatt
    12541 ctgggcgcaa ccctgaaatc gtcacaggtc tccgtgtgat caacatcgaa gaggaagagc
    12601 caacaccgtg gatgaataac cctcgattcc agcactgcat tgcccagggc ggcacgagtg
    12661 agatgaaaag aacgcaggga ggcgccacgg ttgcggtgaa ggcgaggcta cttgaggtga
    12721 cgacgccaga aggaacgctg gaggtgatca cagatgcttt cctccagaag cttcaaatca
    12781 tgctacaggt ccagctacaa aatgacgatg accgtgccaa catcctcatc gccaacgcag
    12841 aagacacggg catcgactcc ctagttgccg tcgagattcg ctcatggttc cagaaggaga
    12901 tggaggtcga cttgccggtc ctcaaaatcc taggcggtgc ggccatcgca gacctcattg
    12961 cttttgccgt cgagaagctg cctgctgcgt tgacgccaaa tctgggcagt gccactagtg
    13021 accgcaggag ggatgagcct gggcatgaca gcagtccacc ggtaactgta cctctgactc
    13081 gccgctccac catgtccgtg ttagcgacgc ccgaccaaac aagcagcaac ggctccgagg
    13141 attgcacatc catttccagc ggcaacacca ctcctaccct tgagtccgag acaaatgtgg
    13201 ccttcctaga ggacgaggac agcgccaagt cgggaagcac ggcgagcggc gagatgcaac
    13261 tgctgggccc gctagtatcc cggccgagcc atccgcaaga attagacctg gaaaggacag
    13321 cgcccatgtc tcttgggcag tcgcgtttct ggtttttgag gcgctatata gaggatcaaa
    13381 caacgttcaa catcacgttc tcagtcaggt tgcggggttc cctgaacctt agcaagttcg
    13441 aatccgcagt ccaaactctg ggccaacgac accaggctct ccggacagcc tttgtgatgg
    13501 aaggggacca gcagcttcca gtgcaagcca tcctcaagag gtcacttctc cacgtcgaaa
    13561 agaagcagat aaagaaggcg catgaggctt ctacagcctt cgaagcaatg aagaaccatg
    13621 tcttcgacat tgaacgagga gagtcgatgc gcctgatggt cctgtcatta agcccgatag
    13681 acagcttcct cgttgtcggg taccaccaca tcaacatgga cggcgcaagt cttgaggtct
    13741 tcatggccga cctgatgaaa ctatataccg gcaagcctct cacgcccaaa cctttccaat
    13801 acccagattt tgcagtgcag caacagcttg aggtgcaaca aggcaggatg gacggcgaca
    13861 ttgcctattg ggaaacccag ttagccggca gccctaccgc gatccccctc cttccctact
    13921 cttcggtgaa gacgcggatg gcgatccaca ggtacgacca caaccgcgtg gatcgcaaaa
    13981 tcgacgccgc cttagcttcc aggatccgcg ccacgtgccg gggggagaag acgtcgcaat
    14041 tccacttcta ccttgccgtg ttccaggtga cattgttccg actgcttggc acgcctgact
    14101 tgtgcattgg catggctgac gccaaccggt tcgaagggga cctcgcctca agtgtcggga
    14161 tgtatctgaa cctcctccct ttgcggttcc gcctgtctgg cagccaaacg ttccaggaca
    14221 ccctcaagga cacccgccgt actgcatacg gggccatggc gcactcgcat gtgccgttcg
    14281 acctcattct gaacagcctc aacgtcccga ggtcaacgct gcatagccct ttgttccagg
    14341 cattcataaa ctaccgagcc ggggtggccg agaagcgaat gctgggagcc gtggaaggcg
    14401 aaggcgagga gtaccacttc ggccggtctg cgtacgatct cagcttggac atcatggaga
    14461 atcccaacag cgatccccgc ctgatgtttg tcgtgcagaa gcagctctac tctgagcagg
    14521 atgcagacgt tttggcggac gcgtacatgc acctgcttga atacttcgcg cagaagccga
    14581 cctcggcgct agaggccgct cccgtgtttg cgccgaagac tgttgaggcg gccatccagc
    14641 ttggtcgagg taagtggaaa ggcttcgatc ctccttagct tcctaaatcc cccctcggct
    14701 gaatgagagc taacctaatg tgtggtcctt gtttcacagg ccgtcccgta gtctctggct
    14761 ggccggaaac catcgttcat cgggtagatg acattgtgca gcgacatccc gacaccattg
    14821 ccatcagaga gacgcaggaa ggacgagtgt ggaactacaa gcagtttggt gaccgaacgg
    14881 ctgctgtcgc aggggcactg ctttctgcca acgtaaccca aggagcgcgc gtcgccgttt
    14941 tccaggagcc aggtttcgac tggatctgct ctgcaatggc cgccatgcgt gtcggcgctg
    15001 tgtttgtccc ctttgatgtc agcacacctg tcgagcgttt aacggccatg gttacaaccg
    15061 cgaagccgac cgtcgtcctc ttccaccgcg cgacagcatc tcaggaggcc agtttagcaa
    15121 ccattcgaga tgggtgtgcc caagccatcg atgtctcgca gccttttcct tccccggtca
    15181 cagggcacga agattatgtc ccaatcatgg ccaaaagcag agaagccgcg attctgtatt
    15241 tcacgagcgg ttcgacaggt gttcccaagg gtgtgatgct cccgcatgac ggtatcccga
    15301 actttatgga gcacacatgt gacgtgaatg ggcctgaagt ggttctgcac cacagcgcgc
    15361 ttgggttcga cctagcaacc tggcaggttc ttgcggccct tgcacacggc ggcaccttag
    15421 tcgtagtgcc gcgggccctg cgtggggacg ctgtcgcaat cacggccctg atggccaagg
    15481 agggtgtgac gtgcacgggg gccactccgt ccgagtacac cagctggatc caatatggct
    15541 tccccaagct cacacaatgc aagggctggc ggcgtgcaat gacgggcggc gagcagtgtt
    15601 cgccaaagct ggtcgaggac ttccgaacgt tgcagcttcc cgatctccgc ctgtggaact
    15661 gctatggacc ttctgaggtt acctggggca gcaaccaagc tgagatcgct ctgacgaagc
    15721 cgctggaggg tgtagtgacg gtcgggaata cgatgcccaa ccgctctgtg tatattctgg
    15781 acgacaacct cgaggctgtt tgcgtcggca tgccaggaga ggtcgttatt ggcggccctg
    15841 gagtgggcct cggatatctc gacaacgatg ctctcacagc agagaggttt ataccggatc
    15901 tctctgcacc gggaacaaga atgtaccgca ccggcgaccg aggacggctg gctgcgaacg
    15961 gagatctgga aatcctgggg cgtatcgatg gcgattcgca gatcaagctg cgcgggatcc
    16021 ggatcgaaat gcaagatatc gagcagacga tccttcgcag cgccaacggc gccttgtcga
    16081 acgtctgtgt gacagcccgg ggtgagcccc cgagcttagt tgcccacgcc gtgtttggac
    16141 cggacttctc gtcgcaagag caggagcagg acgctttcct ccataggcta gccacgtctc
    16201 taccccttcc acaatacatg cgcccagcag ccatcgtgcc aattccggca atgcccctga
    16261 acctcaatgg caagctggac agacgcgcgg tggaaaggat gccgacccgc gccggggatg
    16321 ccgcaatcga gcagcggcct accggctcta ccccgttggg ggaacaggag ctccagttgc
    16381 gccatatctg ggagcacgtc atccccgggg atgttttcgc tctgtacgcg gtgaacaggg
    16441 ataccgactt cttccatgtt ggaggcaact ccatgttgct cgtcaagttg caggacctga
    16501 tcaagcggga gtttggcgtc acgctgacca taatgtctct ctttgagaat agcactcttg
    16561 gcaccatggc ggccgcagtc catgacgcta ccatcgcgag cgccgatgcc gccattgact
    16621 gggaggaaga aacggctttg accaaagacg tcatcgacgg tgcttggcct tcgtcggaga
    16681 aagccgctag gcggcccaag cccgctatcg acgggaaaat catcattctc accggggcaa
    16741 ctggcttcat tgggcgcgag ttgcttgccc agctcatttc gtcctcggca atctcgaagg
    16801 tgtattgtat cgcagtccgc gaccccacca agctggccga cctcgagtcc gaccccaagg
    16861 tttccatcca ccctggcgac ctctcctccc ttgacgacgt cgatgagcac ctcttctcgg
    16921 cagcccatgc tgtgatccac tgcggcgcag atgtgtcctt ccttaaaaca tatgcaacat
    16981 tgcgcagggc gaacgttgcc tcgaccaaag cattggcacg tctcgcgcta aaacacgacg
    17041 tcgatttcca ctacatttcg accatcgcga cagggcgtct actccttgca gaccgctcat
    17101 cggcggctga agacggcagg ccgcagacgg ccaccgcagc gcaggacatc ttccgcgagc
    17161 agtcgctcgc cgatcacccg cccccgccgg gctggttgga taactatgtc gcaagcaagt
    17221 gggccagcga ggtgttcctc gagcgggcgg ctgcgcggct cgggctcaag gcgtgggtgc
    17281 accggccgag cagcgtcacg ggcgctgggg cgggcgagat ggacgtcatg tcttcggtga
    17341 tgcggtacgc taaaagtctt cgggcagtgc cggtgtcggc ccgctggaga ggcgcgttgg
    17401 actttgtggg agtccaggct gtggctgacg gagtggtcaa caccgtgatc aagggacggg
    17461 acggggggaa ccaggagcct gaggggtcta tgaagttcct acatcacagt ggcgacgttg
    17521 tgattcccat cgacgtgctg aaggagtacc tcgaaaagga ggacgcagtc gagtacaaga
    17581 aggtccagct aggggagtgg attgagatgg ccgtgtccga gggattgaac gtgctggtgg
    17641 ccgcgtatct ggcatctgtt gacgagatgg acctggatat tgttttccaa tcctatgtca
    17701 agggtgacat tgtggcttct gtggagggat ga
//
